Gene/Protein Characteristic Table for FHC03950

Species
human

Product ID
FHC03950

Corresponding
Flexi Clone PID

ORF Sequence
DNA sequence (1032 bp)
Protein sequence (344 aa)

Linker Type
Flexi type
The extra Val codon is attached to the 3'-end of the ORF, because a Pme I site ...

Cloning Site
SgfI-PmeI

GenBank Accession
ORF sequence is derived from [AB528023]

Gene
KIEE0773

Symbol

Description
Serine/threonine-protein kinase 12 (EC 2.7.11.1)(Aurora-B)(Aurora- and Ipl1-like midbody-associated protein 1)(AIM-1)(Aurora/IPL1-related kinase 2)(Aurora-related kinase 2)(STK-1)

Original Clone ID
cs02273

Quality control data of this clone

Characterization of the cloned ORF

N-terminal HaloTag-fusions expressed in HEK293 visualized by HaloTag TMR ligand

Features of the cloned ORF sequence

Length: 1032 bp
Restriction map A Restriction map B
Features of the protein sequence

Length: 344 aa
Result of homology search against nr database ( FASTA output, Multiple alignment)
Entry Exp ID% Protein Source
AAC12709 9.4e-133 100.0 aurora-related ...
Homo sapiens
AAQ02457 9.4e-133 100.0 serine/threonin...
synthetic construct
BAG37403 2.2e-132 99.7 unnamed protein...
Homo sapiens
NP_004208 2.2e-132 99.7 aurora kinase B...
Homo sapiens
EAW90076 5.1e-132 99.7 aurora kinase B...
Homo sapiens

The numbers on the left and right sides of a black line in the graphical overview indicate the lengths (in amino acid residues) of the non-homologous N-terminal and C-terminal portions flanking the homologous region (indicated by the black line), respectively.
Result of motif / domain search (InterProScan and SOSUI)
[ zoom out (x2) ] PD000001 PF00069 SM00219 SM00220 PS50011 PS00107 PS00108 PS00092

Result of InterProScan

Search method interpro_ID From To Entry Definition
BlastProDom IPR000719 77 326 PD000001 Protein kinase
HMMPfam IPR000719 77 327 PF00069 Protein kinase
HMMSmart IPR001245 77 327 SM00219 Tyrosine protein kinase
IPR002290 77 327 SM00220 Serine/threonine protein kinase
ProfileScan IPR000719 77 327 PS50011 Protein kinase
ScanRegExp IPR000719 83 106 PS00107 Protein kinase
IPR008271 196 208 PS00108 Serine/threonine protein kinase
IPR002052 267 273 PS00092 N-6 Adenine-specific DNA methylase

Result of homology search against disease genes in OMIM database
(FASTA output, Multiple alignment)
H_id H_len (aa) OMIM_No. ID (%) Q_ali/Q_len (%)
NP_004208 344 604970 99.7 100.0
NP_001015878 309 243060,603495 90.2 88.7
NP_001015879 290 243060,603495 92.3 84.0
NP_940839 403 114500,603072 82.0 90.7
NP_940838 403 114500,603072 82.0 90.7
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