Result of FASTA (omim) for
pFN21AE0773
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0773, 344 aa
1>>>pF1KE0773 344 - 344 aa - 344 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.4614+/-0.000593; mu= -4.7659+/- 0.035
mean_var=522.6926+/-121.801, 0's: 0 Z-trim(115.9): 1959 B-trim: 644 in 1/53
Lambda= 0.056098
statistics sampled from 24015 (26646) to 24015 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.688), E-opt: 0.2 (0.312), width: 16
Scan time: 7.220
The best scores are: opt bits E(85289)
NP_001300879 (OMIM: 604970) aurora kinase B isofor ( 344) 2311 202.3 1.3e-51
NP_004208 (OMIM: 604970) aurora kinase B isoform 1 ( 344) 2311 202.3 1.3e-51
NP_001271455 (OMIM: 604970) aurora kinase B isofor ( 345) 2299 201.3 2.5e-51
NP_001243763 (OMIM: 604970) aurora kinase B isofor ( 303) 2034 179.8 6.6e-45
XP_016880796 (OMIM: 604970) PREDICTED: aurora kina ( 303) 2034 179.8 6.6e-45
NP_001300880 (OMIM: 604970) aurora kinase B isofor ( 303) 2034 179.8 6.6e-45
XP_011522374 (OMIM: 604970) PREDICTED: aurora kina ( 303) 2034 179.8 6.6e-45
NP_001300881 (OMIM: 604970) aurora kinase B isofor ( 304) 2022 178.8 1.3e-44
NP_001015878 (OMIM: 243060,603495) aurora kinase C ( 309) 1590 143.9 4.4e-34
NP_001015879 (OMIM: 243060,603495) aurora kinase C ( 290) 1578 142.9 8.3e-34
NP_003151 (OMIM: 243060,603495) aurora kinase C is ( 275) 1576 142.7 9.1e-34
XP_016880797 (OMIM: 604970) PREDICTED: aurora kina ( 271) 1433 131.1 2.7e-30
XP_011522372 (OMIM: 604970) PREDICTED: aurora kina ( 312) 1433 131.2 3e-30
NP_001300882 (OMIM: 604970) aurora kinase B isofor ( 312) 1433 131.2 3e-30
NP_001310233 (OMIM: 603072) aurora kinase A [Homo ( 403) 1349 124.6 3.8e-28
NP_940839 (OMIM: 603072) aurora kinase A [Homo sap ( 403) 1349 124.6 3.8e-28
NP_001310234 (OMIM: 603072) aurora kinase A [Homo ( 403) 1349 124.6 3.8e-28
NP_940836 (OMIM: 603072) aurora kinase A [Homo sap ( 403) 1349 124.6 3.8e-28
NP_940835 (OMIM: 603072) aurora kinase A [Homo sap ( 403) 1349 124.6 3.8e-28
NP_001310232 (OMIM: 603072) aurora kinase A [Homo ( 403) 1349 124.6 3.8e-28
NP_940838 (OMIM: 603072) aurora kinase A [Homo sap ( 403) 1349 124.6 3.8e-28
XP_016883524 (OMIM: 603072) PREDICTED: aurora kina ( 403) 1349 124.6 3.8e-28
NP_003591 (OMIM: 603072) aurora kinase A [Homo sap ( 403) 1349 124.6 3.8e-28
NP_940837 (OMIM: 603072) aurora kinase A [Homo sap ( 403) 1349 124.6 3.8e-28
XP_016883523 (OMIM: 603072) PREDICTED: aurora kina ( 437) 1349 124.6 3.9e-28
XP_016880798 (OMIM: 604970) PREDICTED: aurora kina ( 192) 1132 106.5 4.9e-23
XP_016880799 (OMIM: 604970) PREDICTED: aurora kina ( 192) 1132 106.5 4.9e-23
NP_001300883 (OMIM: 604970) aurora kinase B isofor ( 192) 1132 106.5 4.9e-23
XP_016880800 (OMIM: 604970) PREDICTED: aurora kina ( 192) 1132 106.5 4.9e-23
NP_001300884 (OMIM: 604970) aurora kinase B isofor ( 176) 1125 105.9 7e-23
XP_005262758 (OMIM: 605031,616171) PREDICTED: seri ( 936) 633 67.2 1.6e-10
XP_016863152 (OMIM: 605031,616171) PREDICTED: seri ( 937) 633 67.2 1.6e-10
NP_055079 (OMIM: 605031,616171) serine/threonine-p ( 970) 633 67.2 1.7e-10
XP_016863151 (OMIM: 605031,616171) PREDICTED: seri ( 971) 633 67.2 1.7e-10
NP_001248745 (OMIM: 605213) 3-phosphoinositide-dep ( 454) 575 62.0 2.9e-09
XP_016878763 (OMIM: 605213) PREDICTED: 3-phosphoin ( 539) 575 62.1 3.2e-09
NP_002604 (OMIM: 605213) 3-phosphoinositide-depend ( 556) 575 62.1 3.2e-09
XP_016878762 (OMIM: 605213) PREDICTED: 3-phosphoin ( 566) 575 62.2 3.2e-09
XP_016878761 (OMIM: 605213) PREDICTED: 3-phosphoin ( 568) 575 62.2 3.3e-09
XP_011520823 (OMIM: 605213) PREDICTED: 3-phosphoin ( 590) 575 62.2 3.3e-09
NP_055655 (OMIM: 608130) NUAK family SNF1-like kin ( 661) 576 62.3 3.3e-09
XP_016878760 (OMIM: 605213) PREDICTED: 3-phosphoin ( 600) 575 62.2 3.3e-09
XP_011541028 (OMIM: 614776) PREDICTED: serine/thre ( 660) 568 61.7 5.2e-09
XP_016872913 (OMIM: 614776) PREDICTED: serine/thre (1213) 568 62.1 7.2e-09
NP_001268678 (OMIM: 614776) serine/threonine-prote (1261) 568 62.1 7.3e-09
XP_005271541 (OMIM: 614776) PREDICTED: serine/thre (1261) 568 62.1 7.3e-09
NP_005035 (OMIM: 300083) cAMP-dependent protein ki ( 358) 556 60.3 7.4e-09
NP_006613 (OMIM: 607023) serine/threonine-protein ( 685) 562 61.2 7.4e-09
XP_011541024 (OMIM: 614776) PREDICTED: serine/thre (1309) 568 62.2 7.5e-09
NP_079440 (OMIM: 614776) serine/threonine-protein (1321) 568 62.2 7.5e-09
>>NP_001300879 (OMIM: 604970) aurora kinase B isoform 1 (344 aa)
initn: 2311 init1: 2311 opt: 2311 Z-score: 1047.8 bits: 202.3 E(85289): 1.3e-51
Smith-Waterman score: 2311; 99.7% identity (99.7% similar) in 344 aa overlap (1-344:1-344)
10 20 30 40 50 60
pF1KE0 MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::
NP_001 PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
250 260 270 280 290 300
310 320 330 340
pF1KE0 QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
310 320 330 340
>>NP_004208 (OMIM: 604970) aurora kinase B isoform 1 [Ho (344 aa)
initn: 2311 init1: 2311 opt: 2311 Z-score: 1047.8 bits: 202.3 E(85289): 1.3e-51
Smith-Waterman score: 2311; 99.7% identity (99.7% similar) in 344 aa overlap (1-344:1-344)
10 20 30 40 50 60
pF1KE0 MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::
NP_004 PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
250 260 270 280 290 300
310 320 330 340
pF1KE0 QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
::::::::::::::::::::::::::::::::::::::::::::
NP_004 QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
310 320 330 340
>>NP_001271455 (OMIM: 604970) aurora kinase B isoform 3 (345 aa)
initn: 1854 init1: 1854 opt: 2299 Z-score: 1042.6 bits: 201.3 E(85289): 2.5e-51
Smith-Waterman score: 2299; 99.4% identity (99.4% similar) in 345 aa overlap (1-344:1-345)
10 20 30 40 50 60
pF1KE0 MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
10 20 30 40 50 60
70 80 90 100 110
pF1KE0 SSGTPDILTR-HFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVE
:::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSGTPDILTRRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 HQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTAT
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE0 IMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDY
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE0 LPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTG
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :
NP_001 LPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMG
250 260 270 280 290 300
300 310 320 330 340
pF1KE0 AQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
:::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
310 320 330 340
>>NP_001243763 (OMIM: 604970) aurora kinase B isoform 2 (303 aa)
initn: 2034 init1: 2034 opt: 2034 Z-score: 927.2 bits: 179.8 E(85289): 6.6e-45
Smith-Waterman score: 2034; 99.7% identity (99.7% similar) in 303 aa overlap (42-344:1-303)
20 30 40 50 60 70
pF1KE0 YGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRH
::::::::::::::::::::::::::::::
NP_001 MSRSNVQPTAAPGQKVMENSSGTPDILTRH
10 20 30
80 90 100 110 120 130
pF1KE0 FTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAH
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE0 LHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYC
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE0 HGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHN
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE0 EKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQDLISKLLRHN
:::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::
NP_001 EKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHN
220 230 240 250 260 270
320 330 340
pF1KE0 PSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
:::::::::::::::::::::::::::::::::
NP_001 PSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
280 290 300
>>XP_016880796 (OMIM: 604970) PREDICTED: aurora kinase B (303 aa)
initn: 2034 init1: 2034 opt: 2034 Z-score: 927.2 bits: 179.8 E(85289): 6.6e-45
Smith-Waterman score: 2034; 99.7% identity (99.7% similar) in 303 aa overlap (42-344:1-303)
20 30 40 50 60 70
pF1KE0 YGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRH
::::::::::::::::::::::::::::::
XP_016 MSRSNVQPTAAPGQKVMENSSGTPDILTRH
10 20 30
80 90 100 110 120 130
pF1KE0 FTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAH
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE0 LHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYC
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE0 HGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHN
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE0 EKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQDLISKLLRHN
:::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::
XP_016 EKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHN
220 230 240 250 260 270
320 330 340
pF1KE0 PSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
:::::::::::::::::::::::::::::::::
XP_016 PSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
280 290 300
>>NP_001300880 (OMIM: 604970) aurora kinase B isoform 2 (303 aa)
initn: 2034 init1: 2034 opt: 2034 Z-score: 927.2 bits: 179.8 E(85289): 6.6e-45
Smith-Waterman score: 2034; 99.7% identity (99.7% similar) in 303 aa overlap (42-344:1-303)
20 30 40 50 60 70
pF1KE0 YGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRH
::::::::::::::::::::::::::::::
NP_001 MSRSNVQPTAAPGQKVMENSSGTPDILTRH
10 20 30
80 90 100 110 120 130
pF1KE0 FTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAH
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE0 LHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYC
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE0 HGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHN
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE0 EKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQDLISKLLRHN
:::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::
NP_001 EKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHN
220 230 240 250 260 270
320 330 340
pF1KE0 PSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
:::::::::::::::::::::::::::::::::
NP_001 PSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
280 290 300
>>XP_011522374 (OMIM: 604970) PREDICTED: aurora kinase B (303 aa)
initn: 2034 init1: 2034 opt: 2034 Z-score: 927.2 bits: 179.8 E(85289): 6.6e-45
Smith-Waterman score: 2034; 99.7% identity (99.7% similar) in 303 aa overlap (42-344:1-303)
20 30 40 50 60 70
pF1KE0 YGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRH
::::::::::::::::::::::::::::::
XP_011 MSRSNVQPTAAPGQKVMENSSGTPDILTRH
10 20 30
80 90 100 110 120 130
pF1KE0 FTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAH
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE0 LHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYC
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE0 HGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHN
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE0 EKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQDLISKLLRHN
:::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::
XP_011 EKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHN
220 230 240 250 260 270
320 330 340
pF1KE0 PSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
:::::::::::::::::::::::::::::::::
XP_011 PSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
280 290 300
>>NP_001300881 (OMIM: 604970) aurora kinase B isoform 4 (304 aa)
initn: 1854 init1: 1854 opt: 2022 Z-score: 921.9 bits: 178.8 E(85289): 1.3e-44
Smith-Waterman score: 2022; 99.3% identity (99.3% similar) in 304 aa overlap (42-344:1-304)
20 30 40 50 60 70
pF1KE0 YGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTR-
:::::::::::::::::::::::::::::
NP_001 MSRSNVQPTAAPGQKVMENSSGTPDILTRR
10 20 30
80 90 100 110 120 130
pF1KE0 HFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQA
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE0 HLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMY
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE0 CHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMH
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE0 NEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQDLISKLLRH
::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
NP_001 NEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRH
220 230 240 250 260 270
320 330 340
pF1KE0 NPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
::::::::::::::::::::::::::::::::::
NP_001 NPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
280 290 300
>>NP_001015878 (OMIM: 243060,603495) aurora kinase C iso (309 aa)
initn: 1576 init1: 1576 opt: 1590 Z-score: 732.9 bits: 143.9 E(85289): 4.4e-34
Smith-Waterman score: 1590; 77.0% identity (90.3% similar) in 309 aa overlap (35-339:3-305)
10 20 30 40 50 60
pF1KE0 ENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPT----AAPGQKVMEN
.: :.: .... ::. :. .: ...
NP_001 MSSPRAVVQLGKA--QPAGEELATANQTAQQP
10 20 30
70 80 90 100 110 120
pF1KE0 SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
:: : . :..:.::::::::::::::::::::: :.:::::::::::::::::::.::
NP_001 SS--PAM--RRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEH
40 50 60 70 80
130 140 150 160 170 180
pF1KE0 QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
::::::::::::.:::::::::::.: ::.::::::::::::::::::: .::::::::
NP_001 QLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATI
90 100 110 120 130 140
190 200 210 220 230 240
pF1KE0 MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
.::::::: ::: ::::::::::::::::..::.::::::::::.:::::::::::::::
NP_001 IEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYL
150 160 170 180 190 200
250 260 270 280 290 300
pF1KE0 PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGA
:::::::: ..:::::::::::::::::: ::::::::.::::::.:::..:: :.: ::
NP_001 PPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGA
210 220 230 240 250 260
310 320 330 340
pF1KE0 QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
.::::.:::..: :::::::. ::::.:.::::::: :
NP_001 RDLISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS
270 280 290 300
>>NP_001015879 (OMIM: 243060,603495) aurora kinase C iso (290 aa)
initn: 1559 init1: 1559 opt: 1578 Z-score: 727.9 bits: 142.9 E(85289): 8.3e-34
Smith-Waterman score: 1578; 80.6% identity (92.4% similar) in 289 aa overlap (51-339:2-286)
30 40 50 60 70 80
pF1KE0 LSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIG
:. .: ... :: : . :..:.::::::
NP_001 MATANQTAQQPSS--PAM--RRLTVDDFEIG
10 20
90 100 110 120 130 140
pF1KE0 RPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRL
::::::::::::::: :.:::::::::::::::::::.::::::::::::::.:::::::
NP_001 RPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRL
30 40 50 60 70 80
150 160 170 180 190 200
pF1KE0 YNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRD
::::.: ::.::::::::::::::::::: .::::::::.::::::: ::: :::::::
NP_001 YNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRD
90 100 110 120 130 140
210 220 230 240 250 260
pF1KE0 IKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIG
:::::::::..::.::::::::::.::::::::::::::::::::::: ..:::::::::
NP_001 IKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIG
150 160 170 180 190 200
270 280 290 300 310 320
pF1KE0 VLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQDLISKLLRHNPSERLPLAQ
::::::::: ::::::::.::::::.:::..:: :.: ::.::::.:::..: :::::::
NP_001 VLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQ
210 220 230 240 250 260
330 340
pF1KE0 VSAHPWVRANSRRVLPPSALQSVA
. ::::.:.::::::: :
NP_001 ILKHPWVQAHSRRVLPPCAQMAS
270 280 290
344 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 18:38:53 2016 done: Sat Nov 5 18:38:55 2016
Total Scan time: 7.220 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]