HUGE

Gene/Protein Characteristic Table for KIAA1044

Link to : Rouge \| GTOP \| SWISS-PROT/TrEMBL \| GeneCards\| RefDIC
Features : DNA sequence \| Protein sequence \| Expression \| Mapping

Product ID :	ORK00720
Accession No. :	AB028967
Description :	Potassium voltage-gated channel subfamily D member 2.
HUGO Gene Name :	potassium voltage-gated channel, Shal-related subfamily, member 2 (KCND2)
Clone Name :	fh03989 [Vector Info]
Flexi ORF Clone :	pF1KSDA1044
Source :	Human fetal brain

Features of the cloned DNA sequence	Description

Length: 5333 bp
Physical map
Restriction map
Prediction of protein coding region (GeneMark analysis) for :
cloned DNA seq.
Warning for N-terminal truncation:
NO

Warning for coding interruption:
NO

Integrity of 3' end

Length of 3'UTR 2475 bp

Genome contig ID gi89161213f_119600958
PolyA signal sequence
(AATAAA,-29)
+----*----+----*----+----*----+----
TACTTAAATAAAACATGTGCATGCTTGAACAGGAC
Flanking genome sequence
(576667 - 576716)
----+----*----+----*----+----*----+----*----+----*
AAAATGTTGACTGTTGCCCTATTTTCTTAGATTTCATTCCTTTCCCAAAA

Ensembl ContigView (Add our DAS server as a DAS source)

Chr f/r start end exon identity class

ContigView(URL based/DAS) 7 f 119700958 120177623 6 99.5 Perfect prediction

Features of the protein sequence	Description

Length: 646 aa

Result of homology search against nr database (FASTA output, Multiple alignment)

Entry	ID%	Protein	Source
Q9NZV8	100.0	Potassium volta...	Homo sapiens
CAH90068	99.7	hypothetical pr...	Pongo abelii
XP_001251585	99.2	similar to pota...	Bos taurus
AAD22053	99.4	potassium chann...	Homo sapiens
AAF65618	99.7	voltage-gated p...	Homo sapiens

The numbers on the left and right sides of a black line in the graphical overview indicate the lengths (in amino acid residues) of the non-homologous N-terminal and C-terminal portions flanking the homologous region (indicated by the black line), respectively.

Result of homology search against other HUGE database (FASTA output, Multiple alignment)

Entry	Exp	ID%	HUGE_ID
AB032970	9.1e-26	30.3	KIAA1144
D79998	0.00026	31.5	KIAA0176

The numbers on the left and right sides of a black line in the graphical overview indicate the lengths (in amino acid residues) of the non-homologous N-terminal and C-terminal portions flanking the homologous region (indicated by the black line), respectively.

Result of motif / domain search (InterProScan and SOSUI)

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Result of InterProScan

Search method interpro_ID From To Entry Definition

FPrintScan IPR004055 46 58 PR01517 Kv4.2 voltage-gated K+ channel

IPR003975 84 97 PR01497 Shal voltage-gated K+ channel

IPR003968 98 108 PR01491 Kv channel

IPR003091 98 117 PR00169 Voltage-dependent potassium channel

IPR003975 159 175 PR01497 Shal voltage-gated K+ channel

IPR004055 164 180 PR01517 Kv4.2 voltage-gated K+ channel

IPR003975 177 191 PR01497 Shal voltage-gated K+ channel

IPR003091 194 222 PR00169 Voltage-dependent potassium channel

IPR003975 196 210 PR01497 Shal voltage-gated K+ channel

IPR003975 236 252 PR01497 Shal voltage-gated K+ channel

IPR003091 247 270 PR00169 Voltage-dependent potassium channel

IPR003091 273 293 PR00169 Voltage-dependent potassium channel

IPR003091 310 336 PR00169 Voltage-dependent potassium channel

IPR003968 315 323 PR01491 Kv channel

IPR003975 334 353 PR01497 Shal voltage-gated K+ channel

IPR003968 339 353 PR01491 Kv channel

IPR003091 339 362 PR00169 Voltage-dependent potassium channel

IPR003091 370 392 PR00169 Voltage-dependent potassium channel

IPR003091 399 425 PR00169 Voltage-dependent potassium channel

IPR003968 410 421 PR01491 Kv channel

IPR003975 431 442 PR01497 Shal voltage-gated K+ channel

IPR003975 445 461 PR01497 Shal voltage-gated K+ channel

IPR004055 477 489 PR01517 Kv4.2 voltage-gated K+ channel

IPR003975 491 505 PR01497 Shal voltage-gated K+ channel

IPR004055 576 589 PR01517 Kv4.2 voltage-gated K+ channel

IPR004055 596 608 PR01517 Kv4.2 voltage-gated K+ channel

HMMPfam IPR003131 59 148 PF02214 K+ channel tetramerisation

IPR005821 247 421 PF00520 Ion transport

HMMSmart IPR000210 57 156 SM00225 BTB/POZ-like

Search method	interpro_ID	From	To	Entry	Definition
FPrintScan	IPR004055	46	58	PR01517	Kv4.2 voltage-gated K+ channel
IPR003975	84	97	PR01497	Shal voltage-gated K+ channel
IPR003968	98	108	PR01491	Kv channel
IPR003091	98	117	PR00169	Voltage-dependent potassium channel
IPR003975	159	175	PR01497	Shal voltage-gated K+ channel
IPR004055	164	180	PR01517	Kv4.2 voltage-gated K+ channel
IPR003975	177	191	PR01497	Shal voltage-gated K+ channel
IPR003091	194	222	PR00169	Voltage-dependent potassium channel
IPR003975	196	210	PR01497	Shal voltage-gated K+ channel
IPR003975	236	252	PR01497	Shal voltage-gated K+ channel
IPR003091	247	270	PR00169	Voltage-dependent potassium channel
IPR003091	273	293	PR00169	Voltage-dependent potassium channel
IPR003091	310	336	PR00169	Voltage-dependent potassium channel
IPR003968	315	323	PR01491	Kv channel
IPR003975	334	353	PR01497	Shal voltage-gated K+ channel
IPR003968	339	353	PR01491	Kv channel
IPR003091	339	362	PR00169	Voltage-dependent potassium channel
IPR003091	370	392	PR00169	Voltage-dependent potassium channel
IPR003091	399	425	PR00169	Voltage-dependent potassium channel
IPR003968	410	421	PR01491	Kv channel
IPR003975	431	442	PR01497	Shal voltage-gated K+ channel
IPR003975	445	461	PR01497	Shal voltage-gated K+ channel
IPR004055	477	489	PR01517	Kv4.2 voltage-gated K+ channel
IPR003975	491	505	PR01497	Shal voltage-gated K+ channel
IPR004055	576	589	PR01517	Kv4.2 voltage-gated K+ channel
IPR004055	596	608	PR01517	Kv4.2 voltage-gated K+ channel
HMMPfam	IPR003131	59	148	PF02214	K+ channel tetramerisation
IPR005821	247	421	PF00520	Ion transport
HMMSmart	IPR000210	57	156	SM00225	BTB/POZ-like

Prediction of transmembrane (TM) segments

Method No. N terminal transmembrane region C terminal type length

SOSUI2 1 12 PLQVIMAAGVAAWLPFARAAAIG 34 PRIMARY 23

2 201 LVFYYVTGFFIAVSVIANVVETV 223 SECONDARY 23

3 242 AVAFFCLDTACVMIFTVEYLLRL 264 SECONDARY 23

4 273 FVRSVMSIIDVVAILPYYIGLVM 295 PRIMARY 23

5 337 ASELGFLLFSLTMAIIIFATVMF 359 PRIMARY 23

6 369 KFTSIPAAFWYTIVTMTTLGYGD 391 SECONDARY 23

7 402 FGSICSLSGVLVIALPVPVIVSN 424 PRIMARY 23

Method	No.	N terminal	transmembrane region	C terminal	type	length
SOSUI2	1	12	PLQVIMAAGVAAWLPFARAAAIG	34	PRIMARY	23
2	201	LVFYYVTGFFIAVSVIANVVETV	223	SECONDARY	23
3	242	AVAFFCLDTACVMIFTVEYLLRL	264	SECONDARY	23
4	273	FVRSVMSIIDVVAILPYYIGLVM	295	PRIMARY	23
5	337	ASELGFLLFSLTMAIIIFATVMF	359	PRIMARY	23
6	369	KFTSIPAAFWYTIVTMTTLGYGD	391	SECONDARY	23
7	402	FGSICSLSGVLVIALPVPVIVSN	424	PRIMARY	23

Expression profile	Description

: RT-PCR-ELISA Description
: Experimental conditions

Primer_f
: CCTAGATACTGTTACAACTGC

Primer_r
: CTACGAATGTGGCTCTTACCG

PCR conditions
: 95 °C30 sec55 °C30 sec72 °C60 sec30 cycles

RT-PCR-ELISA	Description

RH mapping information	Description

Chromosome No.

: 7

Experimental conditions

Panel name	: GeneBridge 4
Primer_f	: CCTAGATACTGTTACAACTGC
Primer_r	: CTACGAATGTGGCTCTTACCG
PCR product length	: 117 bp
PCR conditions	: 95 °C15 sec62 °C60 sec30 cycles

How to obtain KIAA clone(s) Back to the HUGE Protein Database homepage

	cloned DNA seq.
Warning for N-terminal truncation:	NO
Warning for coding interruption:	NO

Length of 3'UTR	2475 bp
Genome contig ID	gi89161213f_119600958
PolyA signal sequence (AATAAA,-29)	+--------+--------+----*----+---- TACTTAAATAAAACATGTGCATGCTTGAACAGGAC
Flanking genome sequence (576667 - 576716)	----+--------+--------+--------+--------+----* AAAATGTTGACTGTTGCCCTATTTTCTTAGATTTCATTCCTTTCCCAAAA

	Chr	f/r	start	end	exon	identity	class
ContigView(URL based/DAS)	7	f	119700958	120177623	6	99.5	Perfect prediction

Gene/Protein Characteristic Table for KIAA1044

Features of the cloned DNA sequence

Features of the protein sequence

Expression profile

RH mapping information