Gene/Protein Characteristic Table for KIAA0422
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Product ID ORK00533
Accession No AB007882
Description adenylate cyclase 6
Clone name hh01205s1
Vector information
The cDNA fragment was inserted at the SalI-NotI site of the ...
cDNA sequence DNA sequence (5877 bp)
Predicted protein sequence (1160 aa)
Flexi ORF Clone FXC00533
Source Human adult brain
Rouge ID mKIAA0422 by Kazusa Mouse cDNA Project
Note We replaced hh01205, former representative clones for KIAA0422 with hh01205s1. (2002/5/10)
Features of the cloned cDNA sequence
Description

Length: 5877 bp
Physical map
Restriction map
Prediction of protein coding region (GeneMark analysis).

N-terminal truncation Coding interruption
cloned DNA seq Warning No warning
Integrity of 3' end
Length of 3'UTR 2393 bp
Genome contig ID gi89161190r_47346248
PolyA signal sequence
(AATAAA,-20)
+----*----+----*----+----*----+----
ATATATTTAAATATCAATAAAATCAAACTCTTTGT
Flanking genome sequence
(100000 - 99951)
----+----*----+----*----+----*----+----*----+----*
AAAATTCTCTGTTCTCTGTAGCTGTTCTGGGCCCTGGGTGGGTCAGAAGT

Ensembl ContigView (Add our DAS server as a DAS source)


Chr f/r start end exon identity class
Ensembl gnome browser 12 r 47446248 47469087 21 100.0 Perfect prediction
Features of the protein sequence
Description

Length: 1160 aa
Result of homology search against nr database (FASTA output, Multiple alignment)
Entry Exp ID% Protein Source
EAW58001 0 100.0 adenylate cycla...
Homo sapiens
XP_001102392 0 99.2 similar to aden...
Macaca mulatta
XP_863292 0 96.6 similar to aden...
Canis lupus fam...
XP_587001 0 95.5 adenylate cycla...
Bos taurus
O43306 0 95.5 Adenylate cycla...
Homo sapiens
The numbers on the left and right sides of a black line in the graphical overview indicate the lengths (in amino acid residues) of the non-homologous N-terminal and C-terminal portions flanking the homologous region (indicated by the black line), respectively.
Result of homology search against HUGE database (FASTA output, Multiple alignment)
Entry Exp ID% HUGE_ID
AB011083 7.7e-46 40.4 KIAA0511
AB028983 2.7e-37 42.4 KIAA1060
D25538 5.3e-37 39.1 KIAA0037
AB011092 5.3e-28 28.9 KIAA0520
The numbers on the left and right sides of a black line in the graphical overview indicate the lengths (in amino acid residues) of the non-homologous N-terminal and C-terminal portions flanking the homologous region (indicated by the black line), respectively.
Result of motif / domain search (InterProScan and SOSUI)

Result of InterProScan

Search method interpro_ID From To Entry Definition
HMMPfam IPR001054 415 599 PF00211 Adenylyl cyclase class-3/4/guanylyl cyclase
IPR009398 605 714 PF06327 Adenylate cyclase-like
IPR001054 962 1156 PF00211 Adenylyl cyclase class-3/4/guanylyl cyclase
HMMSmart IPR001054 378 577 SM00044 Adenylyl cyclase class-3/4/guanylyl cyclase
IPR001054 931 1139 SM00044 Adenylyl cyclase class-3/4/guanylyl cyclase
ProfileScan IPR001054 424 551 PS50125 Adenylyl cyclase class-3/4/guanylyl cyclase
IPR001054 971 1110 PS50125 Adenylyl cyclase class-3/4/guanylyl cyclase
ScanRegExp IPR001054 528 551 PS00452 Adenylyl cyclase class-3/4/guanylyl cyclase
IPR001054 1087 1110 PS00452 Adenylyl cyclase class-3/4/guanylyl cyclase

Prediction of transmembrane (TM) segments
Method No. N terminal transmembrane region C terminal type length
SOSUI2 1 195 SSLTLLMAVLVLLTAVLLAFHA 216 PRIMARY 22
2 226 VALLACAAALFVGLMVVCNRHSF 248 PRIMARY 23
3 253 MWVVSYVVLGILAAVQVGGALAA 275 PRIMARY 23
4 284 LWCPVFFVYIAYTLLPIR 301 PRIMARY 18
5 333 QLGANVLLFLCTNVIGICTHYP 354 SECONDARY 22
6 713 RFGAYVACALLVFCFICFIQLLI 735 PRIMARY 23
7 744 GIYASIFLLLLITVLICAVYSCG 766 PRIMARY 23
8 794 SVLLVFTSAIANMYFIGNMLLSL 816 PRIMARY 23
9 832 AMIFVLGLIYLVLLLLGPPATIF 854 PRIMARY 23
10 886 LKYMTPVILLVFALALYLHAQQV 908 PRIMARY 23
Expression profile
Description

RT-PCR
Experimental conditions
Primer_f ATGGGGTAGGGGTGAGGGTAT
Primer_r GGGTGAGGAAAGGGACAATGG
PCR conditions 95 °C30 sec55 °C30 sec72 °C60 sec30 cycles

RH mapping information
Description

Chromosome No. 12
Experimental conditions
Panel name GeneBridge 4
Primer_f CAACTGGGTGAGGAAAGGGAC
Primer_r TGCTTCTTGCCAGGTGGGAGG
PCR product length 159 bp
PCR conditions 95 °C15 sec68 °C60 sec30 cycles
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