発表論文

2022 2021 2020 2019 2018 2016

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Genome assembly and transcriptomic analyses of the repeatedly rejuvenating jellyfish Turritopsis dohrnii
Yoshinori Hasegawa, Takashi Watanabe, Reo Otsuka, Shigenobu Toné, Shin Kubota, Hideki Hirakawa
DNA Res. 2023;30(1):dsac047.
doi:10.1093/dnares/dsac047

Characterization of proteogenomic signatures of differentiation of CD4⁺ T cell subsets
Toshio Kanno, Ryo Konno, Keisuke Miyako, Takahiro Nakajima, Satoru Yokoyama, Shigemi Sasamoto, Hikari K Asou, Junichiro Ohzeki, Yusuke Kawashima, Yoshinori Hasegawa, Osamu Ohara, Yusuke Endo
DNA Res. 2023;30(1):dsac054.
doi:10.1093/dnares/dsac054

Uterine epithelial Gp130 orchestrates hormone response and epithelial remodeling for successful embryo attachment in mice
Takafumi Namiki, Jumpei Terakawa, Harumi Karakama, Michiko Noguchi, Hironobu Murakami, Yoshinori Hasegawa, Osamu Ohara, Takiko Daikoku, Junya Ito, Naomi Kashiwazaki
Sci Rep. 2023;13(1):854. Published 2023 Jan 16.
doi:10.1038/s41598-023-27859-y

Interleukin-34 cancels anti-tumor immunity by PARP inhibitor
Takayoshi Nakamura, Nabeel Kajihara, Naoki Hama, Takuto Kobayashi, Ryo Otsuka, Nanumi Han, Haruka Wada, Yoshinori Hasegawa, Nao Suzuki, Ken-Ichiro Seino
J Gynecol Oncol. 2023;34(3):e25.
doi:10.3802/jgo.2023.34.e25

PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment
Junichiro Takano, Shinsuke Ito, Yixing Dong, Jafar Sharif, Yaeko Nakajima-Takagi, Taichi Umeyama, Yong-Woon Han, Kyoichi Isono, Takashi Kondo, Yusuke Iizuka, Tomohiro Miyai, Yoko Koseki, Mika Ikegaya, Mizuki Sakihara, Manabu Nakayama, Osamu Ohara, Yoshinori Hasegawa, Kosuke Hashimoto, Erik Arner, Robert J Klose, Atsushi Iwama, Haruhiko Koseki, Tomokatsu Ikawa
Nat Commun. 2022;13(1):7159. Published 2022 Nov 28.
doi:10.1038/s41467-022-34856-8

Proteogenomic landscape and clinical characterization of GH-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors
Azusa Yamato , Hidekazu Nagano , Yue Gao, Tatsuma Matsuda, Naoko Hashimoto, Akitoshi Nakayama, Kazuyuki Yamagata, Masataka Yokoyama, Yingbo Gong, Xiaoyan Shi, Siti Nurul Zhahara, Takashi Kono, Yuki Taki, Naoto Furuki, Motoi Nishimura, Kentaro Horiguchi, Yasuo Iwadate, Masaki Fukuyo, Bahityar Rahmutulla, Atsushi Kaneda, Yoshinori Hasegawa, Yusuke Kawashima, Osamu Ohara, Tetsuo Ishikawa, Eiryo Kawakami, Yasuhiro Nakamura, Naoko Inoshita, Shozo Yamada, Noriaki Fukuhara, Hiroshi Nishioka, Tomoaki Tanaka
Commun Biol. 2022;5(1):1304. Published 2022 Nov 27.
doi:10.1038/s42003-022-04272-1

PTEN overexpression and nuclear β-catenin stabilization promote morular differentiation through induction of epithelial-mesenchymal transition and cancer stem cell-like properties in endometrial carcinoma
Ako Yokoi, Marina Minami, Miki Hashimura, Yasuko Oguri, Toshihide Matsumoto, Yoshinori Hasegawa, Mayu Nakagawa, Yu Ishibashi, Takashi Ito, Kensuke Ohhigata, Youhei Harada, Naomi Fukagawa, Makoto Saegusa
Cell Commun Signal. 2022;20(1):181. Published 2022 Nov 21.
doi:10.1186/s12964-022-00999-w

Functional Polymorphism in Pak1-3′ Untranslated Region Alters Skin Tumor Susceptibility by Alternative Polyadenylation
Kazuhiro Okumura, Megumi Saito, Eriko Isogai, Yurika Tokunaga, Yoshinori Hasegawa, Kimi Araki, Yuichi Wakabayashi
J Invest Dermatol. 2022;142(9):2323-2333.e12.
doi:10.1016/j.jid.2022.02.009

The guppy (Poecilia reticulata) is a useful model for analyzing age-dependent changes in metabolism, motor function, and gene expression
Moeno Imai, Takamasa Mizoguchi, Meng Wang, Yingyi Li, Yoshinori Hasegawa, Ayako Tonoki, Motoyuki Itoh
Exp Gerontol. 2022;160:111708.
doi:10.1016/j.exger.2022.111708

Transcriptome Analysis of Peripheral Blood Mononuclear Cells in Pulmonary Sarcoidosis
Keiichiro Yoshioka, Hironori Sato, Takeshi Kawasaki, Daisuke Ishii, Takuro Imamoto, Mitsuhiro Abe, Yoshinori Hasegawa, Osamu Ohara, Koichiro Tatsumi, Takuji Suzuki
Front Med (Lausanne). 2022;9:822094. Published 2022 Jan 24.
doi:10.3389/fmed.2022.822094

Introduction of a long synthetic repetitive DNA sequence into cultured tobacco cells
Junichirou Ohzeki, Kazuto Kugou, Koichiro Otake, Koei Okazaki, Seiji Takahashi, Daisuke Shibata, Hiroshi Masumoto
Plant Biotechnol (Tokyo). 2022;39(2):101-110.
doi:10.5511/plantbiotechnology.21.1210a

Combination of CENP-B Box Positive and Negative Synthetic Alpha Satellite Repeats Improves De Novo Human Artificial Chromosome Formation
Koei Okazaki, Megumi Nakano, Jun-Ichirou Ohzeki, Koichiro Otake, Kazuto Kugou, Vladimir Larionov, William C Earnshaw, Hiroshi Masumoto
Cells. 2022;11(9):1378. Published 2022 Apr 19.
doi:10.3390/cells11091378

Detailed analysis of Japanese patients with adenosine deaminase 2 deficiency reveals characteristic elevation of type II interferon signature and STAT1 hyperactivation
Hiroshi Nihira, Kazushi Izawa, Moeko Ito, Hiroaki Umebayashi, Tsubasa Okano, Shunsuke Kajikawa, Etsuro Nanishi, Dai Keino, Kosaku Murakami, Masahiko Isa-Nishitani, Takeshi Shiba, Yoshitaka Honda, Atsushi Hijikata, Tadateru Yasu, Tomohiro Kubota, Yoshinori Hasegawa, Yusuke Kawashima, Naoko Nakano, Hidetoshi Takada, Shouichi Ohga, Toshio Heike, Junko Takita, Osamu Ohara, Syuji Takei, Makio Takahashi, Hirokazu Kanegane, Tomohiro Morio, Sachiko Iwaki-Egawa, Yoji Sasahara, Ryuta Nishikomori, Takahiro Yasumi
J Allergy Clin Immunol. 2021;148(2):550-562.
doi:10.1016/j.jaci.2021.01.018

Sjögren’s syndrome-associated SNPs increase GTF2I expression in salivary gland cells to enhance inflammation development
Shuhei Shimoyama, Ikuma Nakagawa, Jing-Jing Jiang, Isao Matsumoto, John A Chiorini, Yoshinori Hasegawa, Osamu Ohara, Rie Hasebe, Mitsutoshi Ota, Mona Uchida, Daisuke Kamimura, Shintaro Hojyo, Yuki Tanaka, Tatsuya Atsumi, Masaaki Murakami
Int Immunol. 2021;33(8):423-434.
doi:10.1093/intimm/dxab025

SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4⁺ T cells
Toshio Kanno, Takahiro Nakajima, Satoru Yokoyama, Hikari K Asou, Shigemi Sasamoto, Yasuhiro Kamii, Koji Hayashizaki, Yasuo Ouchi, Taishi Onodera, Yoshimasa Takahashi, Kazutaka Ikeda, Yoshinori Hasegawa, Yuki Kinjo, Osamu Ohara, Toshinori Nakayama, Yusuke Endo
Commun Biol. 2021;4(1):820. Published 2021 Jun 29.
doi:10.1038/s42003-021-02310-y

Transcriptome analysis of Clavibacter michiganensis subsp. michiganensis-infected tomatoes: a role of salicylic acid in the host response
Naoki Yokotani, Yoshinori Hasegawa, Masaru Sato, Hideki Hirakawa, Yusuke Kouzai, Yoko Nishizawa, Eiji Yamamoto, Yoshiki Naito, Sachiko Isobe
BMC Plant Biol. 2021;21(1):476. Published 2021 Oct 19.
doi:10.1186/s12870-021-03251-8

Anaplastic Lymphoma Kinase Overexpression Is Associated with Aggressive Phenotypic Characteristics of Ovarian High-Grade Serous Carcinoma
Toshihide Matsumoto, Yusuke Oda, Yoshinori Hasegawa, Miki Hashimura, Yasuko Oguri, Hisako Inoue, Ako Yokoi, Masataka Tochimoto, Mayu Nakagawa, Zesong Jiang, Makoto Saegusa
Am J Pathol. 2021;191(10):1837-1850.
doi:10.1016/j.ajpath.2021.06.009

Transplantation of human autologous synovial mesenchymal stem cells with trisomy 7 into the knee joint and 5 years of follow-up
Mitsuru Mizuno, Kentaro Endo, Hisako Katano, Naoki Amano, Masaki Nomura, Yoshinori Hasegawa, Nobutake Ozeki, Hideyuki Koga, Naoko Takasu, Osamu Ohara, Tomohiro Morio, Ichiro Sekiya
Stem Cells Transl Med. 2021;10(11):1530-1543.
doi:10.1002/sctm.20-0491

Functional Roles for CD26/DPP4 in Mediating Inflammatory Responses of Pulmonary Vascular Endothelial Cells
Yukiko Takahashi, Takeshi Kawasaki, Hironori Sato, Yoshinori Hasegawa, Steven M Dudek, Osamu Ohara, Koichiro Tatsumi, Takuji Suzuki
Cells. 2021;10(12):3508. Published 2021 Dec 11.
doi:10.3390/cells10123508

Applications of bottom-up human artificial chromosomes in cell research and cell engineering
Masashi Ikeno, Yoshinori Hasegawa
Exp Cell Res. 2020;390(1):111793.
doi:10.1016/j.yexcr.2019.111793

Upregulation of fibronectin following loss of p53 function is a poor prognostic factor in ovarian carcinoma with a unique immunophenotype
Ako Yokoi, Toshihide Matsumoto, Yasuko Oguri, Yoshinori Hasegawa, Masataka Tochimoto, Mayu Nakagawa, Makoto Saegusa
Cell Commun Signal. 2020;18(1):103. Published 2020 Jul 7.
doi:10.1186/s12964-020-00580-3

Interleukin-34 Limits the Therapeutic Effects of Immune Checkpoint Blockade
Naoki Hama, Takuto Kobayashi, Nanumi Han, Fumihito Kitagawa, Nabeel Kajihara, Ryo Otsuka, Haruka Wada, Hee-Kyung Lee, Hwanseok Rhee, Yoshinori Hasegawa, Hideo Yagita, Muhammad Baghdadi, Ken-Ichiro Seino
iScience. 2020;23(10):101584. Published 2020 Sep 19. [published correction appears in iScience. 2022 Jan 05;25(1):103713].
doi:10.1016/j.isci.2020.101584

PCR-free whole exome sequencing: Cost-effective and efficient in detecting rare mutations
Yamaguchi I, Watanabe T, Ohara O, Hasegawa Y
PLoS One. 2019 Sep 13;14(9):e0222562. doi: 10.1371/journal.pone.0222562. eCollection 2019. PMID: 31518370

Improving the efficiency of gene insertion in a human artificial chromosome vector and its transfer in human-induced pluripotent stem cells
Hasegawa Y, Ikeno M, Suzuki N, Nakayama M, Ohara O
Biol Methods Protoc. 2018 Dec 31;3(1):bpy013. doi: 10.1093/biomethods/bpy013. eCollection 2018. PMID: 32161806

De Novo Assembly of the Transcriptome of Turritopsis, a Jellyfish that Repeatedly Rejuvenates
Hasegawa Y, Watanabe T, Takazawa M, Ohara O, Kubota S
Zoolog Sci. 2016 Aug;33(4):366-71. doi: 10.2108/zs150186. PMID: 27498796