ROUGE

Gene/Protein Characteristic Table for mKIAA0253

Link to : HUGE \| SWISS-PROT/TrEMBL
Features : DNA sequence \| Protein sequence

Accession No. :	AK129102
Description :	Nicastrin precursor.
Clone Name :	mbj00675 [Vector Info]
Source :	Mouse brain

Features of the cloned DNA sequence	Description

Length: 2848 bp
Physical map
Restriction map
Prediction of protein coding region (GeneMark analysis) for :
cloned DNA seq.
Warning for N-terminal truncation:
NO

Warning for coding interruption:
NO

Integrity of 3' end

Length of 3'UTR 654 bp

Genome contig ID gi65488608r_171895006
PolyA signal sequence
(ATTAAA,-18)
+----*----+----*----+----*----+----
TATAAATAGCAAGTTTCATTAAAATTATGCAATAC
Flanking genome sequence
(99935 - 99886)
----+----*----+----*----+----*----+----*----+----*
AATTTGTACTTGTTGTTTGGTATTCTTCCCAGGCCACCGTGTCCAGTGAC

Genomic structure deduced by Blast search against draft genome sequences
Comparison with the corresponding KIAA cDNA.

KIAA Alignment based on:

KIAA0253 DNA sequence, AA sequence, Physical map

KIAA	Alignment based on:
KIAA0253	DNA sequence, AA sequence, Physical map

Features of the protein sequence	Description

Coding region: 32..2194
Length: 720 aa

Result of homology search against nr database (FASTA output, Multiple alignment)

Entry	ID%	Protein	Source
EDL39044	100.0	nicastrin [Mus ...	Mus musculus
P57716	99.7	Nicastrin; Flag...	Mus musculus
AAG11413	99.6	nicastrin [Mus ...	Mus musculus
BAE41750	99.3	unnamed protein...	Mus musculus
BAE43077	99.3	unnamed protein...	Mus musculus

The numbers on the left and right sides of a black line in the graphical overview indicate the lengths (in amino acid residues) of the non-homologous N-terminal and C-terminal portions flanking the homologous region (indicated by the black line), respectively.

Result of homology search against other ROUGE database (FASTA output)
No significant homologues
Result of motif / domain search (InterProScan and SOSUI)

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Result of InterProScan

Search method interpro_ID From To Entry Definition

HMMPfam IPR008710 285 510 PF05450 Nicastrin

ScanRegExp IPR001680 288 302 PS00678 WD-40 repeat

Search method	interpro_ID	From	To	Entry	Definition
HMMPfam	IPR008710	285	510	PF05450	Nicastrin
ScanRegExp	IPR001680	288	302	PS00678	WD-40 repeat

Prediction of transmembrane (TM) segments

Method From To amino acid sequence

SOSUI 28 48 GLLLLFFSVVLAGLCGGNSVE

682 704 ITLIVGFSILIFSLIVTYCINAK

Method	From	To	amino acid sequence
SOSUI	28	48	GLLLLFFSVVLAGLCGGNSVE
682	704	ITLIVGFSILIFSLIVTYCINAK

How to obtain mKIAA clone(s) Back to the ROUGE Protein Database homepage

	cloned DNA seq.
Warning for N-terminal truncation:	NO
Warning for coding interruption:	NO

Length of 3'UTR	654 bp
Genome contig ID	gi65488608r_171895006
PolyA signal sequence (ATTAAA,-18)	+--------+--------+----*----+---- TATAAATAGCAAGTTTCATTAAAATTATGCAATAC
Flanking genome sequence (99935 - 99886)	----+--------+--------+--------+--------+----* AATTTGTACTTGTTGTTTGGTATTCTTCCCAGGCCACCGTGTCCAGTGAC

Gene/Protein Characteristic Table for mKIAA0253

Features of the cloned DNA sequence

Features of the protein sequence