Result of FASTA (omim) for
pF1KB4407
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB4407, 1743 aa
1>>>pF1KB4407 1743 - 1743 aa - 1743 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 14.2951+/-0.000524; mu= -16.9423+/- 0.033
mean_var=578.5735+/-121.618, 0's: 0 Z-trim(122.1): 27 B-trim: 1130 in 1/57
Lambda= 0.053321
statistics sampled from 39741 (39772) to 39741 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.736), E-opt: 0.2 (0.466), width: 16
Scan time: 12.910
The best scores are: opt bits E(85289)
NP_001193937 (OMIM: 159559) afadin isoform 1 [Homo (1743) 11616 910.1 0
XP_006715557 (OMIM: 159559) PREDICTED: afadin isof (1744) 11604 909.2 0
XP_016866374 (OMIM: 159559) PREDICTED: afadin isof (1808) 11108 871.1 0
XP_016866373 (OMIM: 159559) PREDICTED: afadin isof (1816) 10172 799.1 0
XP_016866372 (OMIM: 159559) PREDICTED: afadin isof (1817) 10172 799.1 0
XP_006715554 (OMIM: 159559) PREDICTED: afadin isof (1768) 8964 706.1 7.1e-202
XP_011534144 (OMIM: 159559) PREDICTED: afadin isof (1758) 8963 706.0 7.5e-202
XP_005267053 (OMIM: 159559) PREDICTED: afadin isof (1824) 8493 669.9 5.9e-191
XP_016866371 (OMIM: 159559) PREDICTED: afadin isof (1825) 8493 669.9 5.9e-191
XP_016866376 (OMIM: 159559) PREDICTED: afadin isof (1657) 8468 668.0 2.1e-190
NP_001278893 (OMIM: 159559) afadin isoform 4 [Homo (1781) 8468 668.0 2.2e-190
XP_005267054 (OMIM: 159559) PREDICTED: afadin isof (1823) 8468 668.0 2.2e-190
XP_016866370 (OMIM: 159559) PREDICTED: afadin isof (1830) 8468 668.0 2.2e-190
XP_016866368 (OMIM: 159559) PREDICTED: afadin isof (1831) 8468 668.0 2.2e-190
XP_016866369 (OMIM: 159559) PREDICTED: afadin isof (1831) 8468 668.0 2.2e-190
XP_016866367 (OMIM: 159559) PREDICTED: afadin isof (1832) 8468 668.0 2.2e-190
NP_001035089 (OMIM: 159559) afadin isoform 2 [Homo (1651) 8234 649.9 5.4e-185
XP_016866375 (OMIM: 159559) PREDICTED: afadin isof (1780) 8055 636.2 8e-181
>>NP_001193937 (OMIM: 159559) afadin isoform 1 [Homo sap (1743 aa)
initn: 11616 init1: 11616 opt: 11616 Z-score: 4847.9 bits: 910.1 E(85289): 0
Smith-Waterman score: 11616; 100.0% identity (100.0% similar) in 1743 aa overlap (1-1743:1-1743)
10 20 30 40 50 60
pF1KB4 MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 RVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGERRLDIDEKPLVVQLNWNKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGERRLDIDEKPLVVQLNWNKD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 DREGRFVLKNENDAIPPKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DREGRFVLKNENDAIPPKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQAS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 DKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSSD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 GRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIARVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIARVM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 LPPGAQHSDEKGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDHIPKKTKKHLEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPPGAQHSDEKGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDHIPKKTKKHLEG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 KTPKGKERADGSGYGSTLPPEKLPYLVELSPDGSDSRDKPKLYRLQLSVTEVGTEKLDDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTPKGKERADGSGYGSTLPPEKLPYLVELSPDGSDSRDKPKLYRLQLSVTEVGTEKLDDN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB4 SIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVEGQRISETTMLQSGMKVQFGASHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVEGQRISETTMLQSGMKVQFGASHV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB4 FKFVDPSQDHALAKRSVDGGLMVKGPRHKPGIVQETTFDLGGDIHSGTALPTSKSTTRLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKFVDPSQDHALAKRSVDGGLMVKGPRHKPGIVQETTFDLGGDIHSGTALPTSKSTTRLD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB4 SDRVSSASSTAERGMVKPMIRVEQQPDYRRQESRTQDASGPELILPASIEFRESSEDSFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDRVSSASSTAERGMVKPMIRVEQQPDYRRQESRTQDASGPELILPASIEFRESSEDSFL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB4 SAIINYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTERTHKVIAVVNKMVSMMEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAIINYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTERTHKVIAVVNKMVSMMEG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB4 VIQKQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLAHLVQMAFKYLVHCLQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VIQKQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLAHLVQMAFKYLVHCLQS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB4 ELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINM
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB4 WLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQATTLLTMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQATTLLTMD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB4 KYAPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIENVVTVAENTADELARS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KYAPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIENVVTVAENTADELARS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB4 DGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLCQRGFCRLIPHTRSPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLCQRGFCRLIPHTRSPGT
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB4 WTIYFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WTIYFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIY
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB4 VKSVVKGGAADDGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKSVVKGGAADDGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYH
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB4 GLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEPKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEPKKL
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KB4 PGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAKITSVSTGNLCTEEQTPPPRPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAKITSVSTGNLCTEEQTPPPRPE
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KB4 AYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMHTDSNHSSIAIQRVTRSQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMHTDSNHSSIAIQRVTRSQE
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KB4 ELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQEHLNHSSKSVTPASTLTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQEHLNHSSKSVTPASTLTK
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KB4 SGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDFDGMSMDLPLPPPPSANQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDFDGMSMDLPLPPPPSANQI
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KB4 GLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQERKLGQMRTQSLNPAPFSPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQERKLGQMRTQSLNPAPFSPL
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KB4 TAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYITVSKEELSSGDSLSPDPWK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYITVSKEELSSGDSLSPDPWK
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KB4 RDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRKLMLEWQFQKRLQESKQKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRKLMLEWQFQKRLQESKQKD
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KB4 EDDEEEEDDDVDTMLIMQRLEAERRARLQDEERRRQQQLEEMRKREAEDRARQEEERRRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDDEEEEDDDVDTMLIMQRLEAERRARLQDEERRRQQQLEEMRKREAEDRARQEEERRRQ
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KB4 EEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLEPEAPGPNSYPGSTGAAVGAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLEPEAPGPNSYPGSTGAAVGAH
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KB4 DACRDAKEKRSKSQDADSPGSSGAPENLTFKERQRLFSQGQDVSNKVKASRKLTELENEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DACRDAKEKRSKSQDADSPGSSGAPENLTFKERQRLFSQGQDVSNKVKASRKLTELENEL
1690 1700 1710 1720 1730 1740
pF1KB4 NTK
:::
NP_001 NTK
>>XP_006715557 (OMIM: 159559) PREDICTED: afadin isoform (1744 aa)
initn: 11602 init1: 6863 opt: 11604 Z-score: 4842.9 bits: 909.2 E(85289): 0
Smith-Waterman score: 11604; 99.9% identity (99.9% similar) in 1744 aa overlap (1-1743:1-1744)
10 20 30 40 50 60
pF1KB4 MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 RVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGERRLDIDEKPLVVQLNWNKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGERRLDIDEKPLVVQLNWNKD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 DREGRFVLKNENDAIPPKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DREGRFVLKNENDAIPPKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQAS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 DKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSSD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 GRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIARVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIARVM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 LPPGAQHSDEKGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDHIPKKTKKHLEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LPPGAQHSDEKGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDHIPKKTKKHLEG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 KTPKGKERADGSGYGSTLPPEKLPYLVELSPDGSDSRDKPKLYRLQLSVTEVGTEKLDDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KTPKGKERADGSGYGSTLPPEKLPYLVELSPDGSDSRDKPKLYRLQLSVTEVGTEKLDDN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB4 SIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVEGQRISETTMLQSGMKVQFGASHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVEGQRISETTMLQSGMKVQFGASHV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB4 FKFVDPSQDHALAKRSVDGGLMVKGPRHKPGIVQETTFDLGGDIHSGTALPTSKSTTRLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FKFVDPSQDHALAKRSVDGGLMVKGPRHKPGIVQETTFDLGGDIHSGTALPTSKSTTRLD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB4 SDRVSSASSTAERGMVKPMIRVEQQPDYRRQESRTQDASGPELILPASIEFRESSEDSFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SDRVSSASSTAERGMVKPMIRVEQQPDYRRQESRTQDASGPELILPASIEFRESSEDSFL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB4 SAIINYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTERTHKVIAVVNKMVSMMEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SAIINYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTERTHKVIAVVNKMVSMMEG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB4 VIQKQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLAHLVQMAFKYLVHCLQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VIQKQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLAHLVQMAFKYLVHCLQS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB4 ELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINM
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB4 WLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQATTLLTMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQATTLLTMD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB4 KYAPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIENVVTVAENTADELARS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KYAPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIENVVTVAENTADELARS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB4 DGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLCQRGFCRLIPHTRSPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLCQRGFCRLIPHTRSPGT
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB4 WTIYFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WTIYFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIY
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070
pF1KB4 VKSVVKGGAAD-DGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIY
::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIY
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KB4 HGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEPKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEPKK
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KB4 LPGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAKITSVSTGNLCTEEQTPPPRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LPGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAKITSVSTGNLCTEEQTPPPRP
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KB4 EAYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMHTDSNHSSIAIQRVTRSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EAYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMHTDSNHSSIAIQRVTRSQ
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300 1310
pF1KB4 EELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQEHLNHSSKSVTPASTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQEHLNHSSKSVTPASTLT
1270 1280 1290 1300 1310 1320
1320 1330 1340 1350 1360 1370
pF1KB4 KSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDFDGMSMDLPLPPPPSANQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDFDGMSMDLPLPPPPSANQ
1330 1340 1350 1360 1370 1380
1380 1390 1400 1410 1420 1430
pF1KB4 IGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQERKLGQMRTQSLNPAPFSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQERKLGQMRTQSLNPAPFSP
1390 1400 1410 1420 1430 1440
1440 1450 1460 1470 1480 1490
pF1KB4 LTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYITVSKEELSSGDSLSPDPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYITVSKEELSSGDSLSPDPW
1450 1460 1470 1480 1490 1500
1500 1510 1520 1530 1540 1550
pF1KB4 KRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRKLMLEWQFQKRLQESKQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRKLMLEWQFQKRLQESKQK
1510 1520 1530 1540 1550 1560
1560 1570 1580 1590 1600 1610
pF1KB4 DEDDEEEEDDDVDTMLIMQRLEAERRARLQDEERRRQQQLEEMRKREAEDRARQEEERRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DEDDEEEEDDDVDTMLIMQRLEAERRARLQDEERRRQQQLEEMRKREAEDRARQEEERRR
1570 1580 1590 1600 1610 1620
1620 1630 1640 1650 1660 1670
pF1KB4 QEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLEPEAPGPNSYPGSTGAAVGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLEPEAPGPNSYPGSTGAAVGA
1630 1640 1650 1660 1670 1680
1680 1690 1700 1710 1720 1730
pF1KB4 HDACRDAKEKRSKSQDADSPGSSGAPENLTFKERQRLFSQGQDVSNKVKASRKLTELENE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HDACRDAKEKRSKSQDADSPGSSGAPENLTFKERQRLFSQGQDVSNKVKASRKLTELENE
1690 1700 1710 1720 1730 1740
1740
pF1KB4 LNTK
::::
XP_006 LNTK
>>XP_016866374 (OMIM: 159559) PREDICTED: afadin isoform (1808 aa)
initn: 11095 init1: 6863 opt: 11108 Z-score: 4636.4 bits: 871.1 E(85289): 0
Smith-Waterman score: 11265; 96.3% identity (96.3% similar) in 1775 aa overlap (1-1710:1-1775)
10 20 30 40 50 60
pF1KB4 MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 RVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGERRLDIDEKPLVVQLNWNKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGERRLDIDEKPLVVQLNWNKD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 DREGRFVLKNENDAIPPKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DREGRFVLKNENDAIPPKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQAS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 DKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSSD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 GRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIARVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIARVM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 LPPGAQHSDEKGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDHIPKKTKKHLEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPPGAQHSDEKGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDHIPKKTKKHLEG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 KTPKGKERADGSGYGSTLPPEKLPYLVELSPDGSDSRDKPKLYRLQLSVTEVGTEKLDDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTPKGKERADGSGYGSTLPPEKLPYLVELSPDGSDSRDKPKLYRLQLSVTEVGTEKLDDN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB4 SIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVEGQRISETTMLQSGMKVQFGASHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVEGQRISETTMLQSGMKVQFGASHV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB4 FKFVDPSQDHALAKRSVDGGLMVKGPRHKPGIVQETTFDLGGDIHSGTALPTSKSTTRLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKFVDPSQDHALAKRSVDGGLMVKGPRHKPGIVQETTFDLGGDIHSGTALPTSKSTTRLD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB4 SDRVSSASSTAERGMVKPMIRVEQQPDYRRQESRTQDASGPELILPASIEFRESSEDSFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDRVSSASSTAERGMVKPMIRVEQQPDYRRQESRTQDASGPELILPASIEFRESSEDSFL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB4 SAIINYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTERTHKVIAVVNKMVSMMEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAIINYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTERTHKVIAVVNKMVSMMEG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB4 VIQKQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLAHLVQMAFKYLVHCLQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VIQKQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLAHLVQMAFKYLVHCLQS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB4 ELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINM
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB4 WLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQATTLLTMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQATTLLTMD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB4 KYAPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIENVVTVAENTADELARS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KYAPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIENVVTVAENTADELARS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB4 DGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLCQRGFCRLIPHTRSPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLCQRGFCRLIPHTRSPGT
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB4 WTIYFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WTIYFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIY
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070
pF1KB4 VKSVVKGGAAD-DGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIY
::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIY
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KB4 HGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEPKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEPKK
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KB4 LPGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAKITSVSTGNLCTEEQTPPPRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAKITSVSTGNLCTEEQTPPPRP
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KB4 EAYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMHTDSNHSSIAIQRVTRSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMHTDSNHSSIAIQRVTRSQ
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300 1310
pF1KB4 EELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQEHLNHSSKSVTPASTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQEHLNHSSKSVTPASTLT
1270 1280 1290 1300 1310 1320
1320 1330 1340 1350 1360 1370
pF1KB4 KSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDFDGMSMDLPLPPPPSANQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDFDGMSMDLPLPPPPSANQ
1330 1340 1350 1360 1370 1380
1380 1390 1400 1410 1420 1430
pF1KB4 IGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQERKLGQMRTQSLNPAPFSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQERKLGQMRTQSLNPAPFSP
1390 1400 1410 1420 1430 1440
1440 1450 1460 1470 1480 1490
pF1KB4 LTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYITVSKEELSSGDSLSPDPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYITVSKEELSSGDSLSPDPW
1450 1460 1470 1480 1490 1500
1500 1510 1520 1530 1540 1550
pF1KB4 KRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRKLMLEWQFQKRLQESKQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRKLMLEWQFQKRLQESKQK
1510 1520 1530 1540 1550 1560
1560 1570 1580 1590 1600 1610
pF1KB4 DEDDEEEEDDDVDTMLIMQRLEAERRARLQDEERRRQQQLEEMRKREAEDRARQEEERRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DEDDEEEEDDDVDTMLIMQRLEAERRARLQDEERRRQQQLEEMRKREAEDRARQEEERRR
1570 1580 1590 1600 1610 1620
1620 1630 1640 1650 1660
pF1KB4 QEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLEPEAPG--------------
::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLEPEAPGLCRPPLPRDYEPPS
1630 1640 1650 1660 1670 1680
1670
pF1KB4 --------------------------------------------------PNSYPGSTGA
::::::::::
XP_016 PSPAPGAPPPPPQRNASYLKTQVLSPDSLFTAKFVAYNEEEEEEDCSLAGPNSYPGSTGA
1690 1700 1710 1720 1730 1740
1680 1690 1700 1710 1720 1730
pF1KB4 AVGAHDACRDAKEKRSKSQDADSPGSSGAPENLTFKERQRLFSQGQDVSNKVKASRKLTE
:::::::::::::::::::::::::::::::::::
XP_016 AVGAHDACRDAKEKRSKSQDADSPGSSGAPENLTFKERQRLFSQGQDVSNKVKASRKLTE
1750 1760 1770 1780 1790 1800
1740
pF1KB4 LENELNTK
XP_016 LENELNTK
>>XP_016866373 (OMIM: 159559) PREDICTED: afadin isoform (1816 aa)
initn: 7711 init1: 4246 opt: 10172 Z-score: 4247.3 bits: 799.1 E(85289): 0
Smith-Waterman score: 11235; 95.9% identity (95.9% similar) in 1784 aa overlap (1-1711:1-1784)
10 20 30 40 50 60
pF1KB4 MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 RVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGERRLDIDEKPLVVQLNWNKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGERRLDIDEKPLVVQLNWNKD
70 80 90 100 110 120
130 140 150 160 170
pF1KB4 DREGRFVLKNENDAIPPK-AQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQA
:::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::
XP_016 DREGRFVLKNENDAIPPKKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQA
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB4 SDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSS
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB4 DGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIARV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIARV
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB4 MLPPGAQHSDEKGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDHIPKKTKKHLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MLPPGAQHSDEKGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDHIPKKTKKHLE
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB4 GKTPKGKERADGSGYGSTLPPEKLPYLVELSPDGSDSRDKPKLYRLQLSVTEVGTEKLDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKTPKGKERADGSGYGSTLPPEKLPYLVELSPDGSDSRDKPKLYRLQLSVTEVGTEKLDD
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB4 NSIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVEGQRISETTMLQSGMKVQFGASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVEGQRISETTMLQSGMKVQFGASH
430 440 450 460 470 480
480 490 500 510 520 530
pF1KB4 VFKFVDPSQDHALAKRSVDGGLMVKGPRHKPGIVQETTFDLGGDIHSGTALPTSKSTTRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VFKFVDPSQDHALAKRSVDGGLMVKGPRHKPGIVQETTFDLGGDIHSGTALPTSKSTTRL
490 500 510 520 530 540
540 550 560 570 580 590
pF1KB4 DSDRVSSASSTAERGMVKPMIRVEQQPDYRRQESRTQDASGPELILPASIEFRESSEDSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSDRVSSASSTAERGMVKPMIRVEQQPDYRRQESRTQDASGPELILPASIEFRESSEDSF
550 560 570 580 590 600
600 610 620 630 640 650
pF1KB4 LSAIINYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTERTHKVIAVVNKMVSMME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSAIINYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTERTHKVIAVVNKMVSMME
610 620 630 640 650 660
660 670 680 690 700 710
pF1KB4 GVIQ-------KQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLAHLVQMAFK
:::: :::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVIQEVDQVDQKQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLAHLVQMAFK
670 680 690 700 710 720
720 730 740 750 760 770
pF1KB4 YLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTIQLFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTIQLFS
730 740 750 760 770 780
780 790 800 810 820 830
pF1KB4 QLFHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLFHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQ
790 800 810 820 830 840
840 850 860 870 880 890
pF1KB4 ATTLLTMDKYAPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIENVVTVAEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATTLLTMDKYAPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIENVVTVAEN
850 860 870 880 890 900
900 910 920 930 940 950
pF1KB4 TADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLCQRGFCRLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLCQRGFCRLI
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KB4 PHTRSPGTWTIYFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMGLSIVAAKGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PHTRSPGTWTIYFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMGLSIVAAKGA
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KB4 GQDKLGIYVKSVVKGGAAD-DGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSSVVTLE
::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::
XP_016 GQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSSVVTLE
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KB4 VAKQGAIYHGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNGSPESPQLPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VAKQGAIYHGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNGSPESPQLPW
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KB4 AEYSEPKKLPGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAKITSVSTGNLCTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEYSEPKKLPGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAKITSVSTGNLCTE
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KB4 EQTPPPRPEAYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMHTDSNHSSIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQTPPPRPEAYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMHTDSNHSSIA
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300 1310
pF1KB4 IQRVTRSQEELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQEHLNHSSKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQRVTRSQEELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQEHLNHSSKS
1270 1280 1290 1300 1310 1320
1320 1330 1340 1350 1360 1370
pF1KB4 VTPASTLTKSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDFDGMSMDLPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTPASTLTKSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDFDGMSMDLPL
1330 1340 1350 1360 1370 1380
1380 1390 1400 1410 1420 1430
pF1KB4 PPPPSANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQERKLGQMRTQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPPPSANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQERKLGQMRTQS
1390 1400 1410 1420 1430 1440
1440 1450 1460 1470 1480 1490
pF1KB4 LNPAPFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYITVSKEELSSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNPAPFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYITVSKEELSSG
1450 1460 1470 1480 1490 1500
1500 1510 1520 1530 1540 1550
pF1KB4 DSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRKLMLEWQFQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRKLMLEWQFQK
1510 1520 1530 1540 1550 1560
1560 1570 1580 1590 1600 1610
pF1KB4 RLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRARLQDEERRRQQQLEEMRKREAEDRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRARLQDEERRRQQQLEEMRKREAEDRA
1570 1580 1590 1600 1610 1620
1620 1630 1640 1650 1660
pF1KB4 RQEEERRRQEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLEPEAPG------
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQEEERRRQEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLEPEAPGLCRPPL
1630 1640 1650 1660 1670 1680
pF1KB4 ----------------------------------------------------------PN
::
XP_016 PRDYEPPSPSPAPGAPPPPPQRNASYLKTQVLSPDSLFTAKFVAYNEEEEEEDCSLAGPN
1690 1700 1710 1720 1730 1740
1670 1680 1690 1700 1710 1720
pF1KB4 SYPGSTGAAVGAHDACRDAKEKRSKSQDADSPGSSGAPENLTFKERQRLFSQGQDVSNKV
::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYPGSTGAAVGAHDACRDAKEKRSKSQDADSPGSSGAPENLTFKERQRLFSQGQDVSNKV
1750 1760 1770 1780 1790 1800
1730 1740
pF1KB4 KASRKLTELENELNTK
XP_016 KASRKLTELENELNTK
1810
>>XP_016866372 (OMIM: 159559) PREDICTED: afadin isoform (1817 aa)
initn: 8375 init1: 4246 opt: 10172 Z-score: 4247.3 bits: 799.1 E(85289): 0
Smith-Waterman score: 11223; 95.9% identity (95.9% similar) in 1785 aa overlap (1-1711:1-1785)
10 20 30 40 50 60
pF1KB4 MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCI
10 20 30 40 50 60
70 80 90 100 110
pF1KB4 RVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGE-RRLDIDEKPLVVQLNWNK
::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::
XP_016 RVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGEERRLDIDEKPLVVQLNWNK
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB4 DDREGRFVLKNENDAIPPK-AQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQ
::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::
XP_016 DDREGRFVLKNENDAIPPKKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQ
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB4 ASDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRS
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB4 SDGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIAR
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB4 VMLPPGAQHSDEKGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDHIPKKTKKHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMLPPGAQHSDEKGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDHIPKKTKKHL
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB4 EGKTPKGKERADGSGYGSTLPPEKLPYLVELSPDGSDSRDKPKLYRLQLSVTEVGTEKLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGKTPKGKERADGSGYGSTLPPEKLPYLVELSPDGSDSRDKPKLYRLQLSVTEVGTEKLD
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB4 DNSIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVEGQRISETTMLQSGMKVQFGAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DNSIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVEGQRISETTMLQSGMKVQFGAS
430 440 450 460 470 480
480 490 500 510 520 530
pF1KB4 HVFKFVDPSQDHALAKRSVDGGLMVKGPRHKPGIVQETTFDLGGDIHSGTALPTSKSTTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVFKFVDPSQDHALAKRSVDGGLMVKGPRHKPGIVQETTFDLGGDIHSGTALPTSKSTTR
490 500 510 520 530 540
540 550 560 570 580 590
pF1KB4 LDSDRVSSASSTAERGMVKPMIRVEQQPDYRRQESRTQDASGPELILPASIEFRESSEDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDSDRVSSASSTAERGMVKPMIRVEQQPDYRRQESRTQDASGPELILPASIEFRESSEDS
550 560 570 580 590 600
600 610 620 630 640 650
pF1KB4 FLSAIINYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTERTHKVIAVVNKMVSMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLSAIINYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTERTHKVIAVVNKMVSMM
610 620 630 640 650 660
660 670 680 690 700 710
pF1KB4 EGVIQ-------KQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLAHLVQMAF
::::: ::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGVIQEVDQVDQKQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLAHLVQMAF
670 680 690 700 710 720
720 730 740 750 760 770
pF1KB4 KYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTIQLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTIQLF
730 740 750 760 770 780
780 790 800 810 820 830
pF1KB4 SQLFHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAADCHLSRIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQLFHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAADCHLSRIV
790 800 810 820 830 840
840 850 860 870 880 890
pF1KB4 QATTLLTMDKYAPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIENVVTVAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QATTLLTMDKYAPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIENVVTVAE
850 860 870 880 890 900
900 910 920 930 940 950
pF1KB4 NTADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLCQRGFCRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NTADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLCQRGFCRL
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KB4 IPHTRSPGTWTIYFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMGLSIVAAKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPHTRSPGTWTIYFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMGLSIVAAKG
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KB4 AGQDKLGIYVKSVVKGGAAD-DGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSSVVTL
:::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::
XP_016 AGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSSVVTL
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KB4 EVAKQGAIYHGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNGSPESPQLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVAKQGAIYHGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNGSPESPQLP
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KB4 WAEYSEPKKLPGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAKITSVSTGNLCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WAEYSEPKKLPGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAKITSVSTGNLCT
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KB4 EEQTPPPRPEAYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMHTDSNHSSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEQTPPPRPEAYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMHTDSNHSSI
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300 1310
pF1KB4 AIQRVTRSQEELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQEHLNHSSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AIQRVTRSQEELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQEHLNHSSK
1270 1280 1290 1300 1310 1320
1320 1330 1340 1350 1360 1370
pF1KB4 SVTPASTLTKSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDFDGMSMDLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVTPASTLTKSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDFDGMSMDLP
1330 1340 1350 1360 1370 1380
1380 1390 1400 1410 1420 1430
pF1KB4 LPPPPSANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQERKLGQMRTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPPPPSANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQERKLGQMRTQ
1390 1400 1410 1420 1430 1440
1440 1450 1460 1470 1480 1490
pF1KB4 SLNPAPFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYITVSKEELSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLNPAPFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYITVSKEELSS
1450 1460 1470 1480 1490 1500
1500 1510 1520 1530 1540 1550
pF1KB4 GDSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRKLMLEWQFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRKLMLEWQFQ
1510 1520 1530 1540 1550 1560
1560 1570 1580 1590 1600 1610
pF1KB4 KRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRARLQDEERRRQQQLEEMRKREAEDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRARLQDEERRRQQQLEEMRKREAEDR
1570 1580 1590 1600 1610 1620
1620 1630 1640 1650 1660
pF1KB4 ARQEEERRRQEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLEPEAPG-----
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARQEEERRRQEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLEPEAPGLCRPP
1630 1640 1650 1660 1670 1680
pF1KB4 -----------------------------------------------------------P
:
XP_016 LPRDYEPPSPSPAPGAPPPPPQRNASYLKTQVLSPDSLFTAKFVAYNEEEEEEDCSLAGP
1690 1700 1710 1720 1730 1740
1670 1680 1690 1700 1710 1720
pF1KB4 NSYPGSTGAAVGAHDACRDAKEKRSKSQDADSPGSSGAPENLTFKERQRLFSQGQDVSNK
:::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSYPGSTGAAVGAHDACRDAKEKRSKSQDADSPGSSGAPENLTFKERQRLFSQGQDVSNK
1750 1760 1770 1780 1790 1800
1730 1740
pF1KB4 VKASRKLTELENELNTK
XP_016 VKASRKLTELENELNTK
1810
>>XP_006715554 (OMIM: 159559) PREDICTED: afadin isoform (1768 aa)
initn: 9591 init1: 4753 opt: 8964 Z-score: 3745.2 bits: 706.1 E(85289): 7.1e-202
Smith-Waterman score: 11516; 98.6% identity (98.6% similar) in 1768 aa overlap (1-1743:1-1768)
10 20 30 40 50 60
pF1KB4 MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCI
10 20 30 40 50 60
70 80 90 100 110
pF1KB4 RVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGE-RRLDIDEKPLVVQLNWNK
::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::
XP_006 RVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGEERRLDIDEKPLVVQLNWNK
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB4 DDREGRFVLKNENDAIPPK-AQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQ
::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::
XP_006 DDREGRFVLKNENDAIPPKKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQ
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB4 ASDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ASDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRS
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB4 SDGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SDGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIAR
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB4 VMLPPGAQHSDEKGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDHIPKKTKKHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VMLPPGAQHSDEKGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDHIPKKTKKHL
310 320 330 340 350 360
360 370 380 390 400
pF1KB4 EGKTPKGKERADGSGYGSTLPPEKLPYLVELSP---------------DGSDSRDKPKLY
::::::::::::::::::::::::::::::::: ::::::::::::
XP_006 EGKTPKGKERADGSGYGSTLPPEKLPYLVELSPGRRNHFAYYNYHTYEDGSDSRDKPKLY
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB4 RLQLSVTEVGTEKLDDNSIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVEGQRISE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLQLSVTEVGTEKLDDNSIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVEGQRISE
430 440 450 460 470 480
470 480 490 500 510 520
pF1KB4 TTMLQSGMKVQFGASHVFKFVDPSQDHALAKRSVDGGLMVKGPRHKPGIVQETTFDLGGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TTMLQSGMKVQFGASHVFKFVDPSQDHALAKRSVDGGLMVKGPRHKPGIVQETTFDLGGD
490 500 510 520 530 540
530 540 550 560 570 580
pF1KB4 IHSGTALPTSKSTTRLDSDRVSSASSTAERGMVKPMIRVEQQPDYRRQESRTQDASGPEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IHSGTALPTSKSTTRLDSDRVSSASSTAERGMVKPMIRVEQQPDYRRQESRTQDASGPEL
550 560 570 580 590 600
590 600 610 620 630 640
pF1KB4 ILPASIEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ILPASIEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTER
610 620 630 640 650 660
650 660 670 680 690
pF1KB4 THKVIAVVNKMVSMMEGVIQ-------KQKNIAGALAFWMANASELLNFIKQDRDLSRIT
:::::::::::::::::::: :::::::::::::::::::::::::::::::::
XP_006 THKVIAVVNKMVSMMEGVIQEVDQVDQKQKNIAGALAFWMANASELLNFIKQDRDLSRIT
670 680 690 700 710 720
700 710 720 730 740 750
pF1KB4 LDAQDVLAHLVQMAFKYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LDAQDVLAHLVQMAFKYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSL
730 740 750 760 770 780
760 770 780 790 800 810
pF1KB4 LRRCRVNAALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LRRCRVNAALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEK
790 800 810 820 830 840
820 830 840 850 860 870
pF1KB4 QGLELAADCHLSRIVQATTLLTMDKYAPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QGLELAADCHLSRIVQATTLLTMDKYAPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEP
850 860 870 880 890 900
880 890 900 910 920 930
pF1KB4 FIPTDLIENVVTVAENTADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FIPTDLIENVVTVAENTADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGL
910 920 930 940 950 960
940 950 960 970 980 990
pF1KB4 QEFLDPLCQRGFCRLIPHTRSPGTWTIYFEGADYESHLLRENTELAQPLRKEPEIITVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QEFLDPLCQRGFCRLIPHTRSPGTWTIYFEGADYESHLLRENTELAQPLRKEPEIITVTL
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KB4 KKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAAD-DGRLAAGDQLLSVDGRSLVGLSQE
::::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::
XP_006 KKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQE
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KB4 RAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELY
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KB4 NNSTQNGSPESPQLPWAEYSEPKKLPGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NNSTQNGSPESPQLPWAEYSEPKKLPGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASG
1150 1160 1170 1180 1190 1200
1180 1190 1200 1210 1220 1230
pF1KB4 TTAKITSVSTGNLCTEEQTPPPRPEAYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TTAKITSVSTGNLCTEEQTPPPRPEAYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNY
1210 1220 1230 1240 1250 1260
1240 1250 1260 1270 1280 1290
pF1KB4 EEKPHMHTDSNHSSIAIQRVTRSQEELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEKPHMHTDSNHSSIAIQRVTRSQEELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSL
1270 1280 1290 1300 1310 1320
1300 1310 1320 1330 1340 1350
pF1KB4 DSSTSSQEHLNHSSKSVTPASTLTKSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DSSTSSQEHLNHSSKSVTPASTLTKSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPP
1330 1340 1350 1360 1370 1380
1360 1370 1380 1390 1400 1410
pF1KB4 VHYAGDFDGMSMDLPLPPPPSANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEEERER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VHYAGDFDGMSMDLPLPPPPSANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEEERER
1390 1400 1410 1420 1430 1440
1420 1430 1440 1450 1460 1470
pF1KB4 KRREQERKLGQMRTQSLNPAPFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KRREQERKLGQMRTQSLNPAPFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIER
1450 1460 1470 1480 1490 1500
1480 1490 1500 1510 1520 1530
pF1KB4 RDLQYITVSKEELSSGDSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RDLQYITVSKEELSSGDSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAE
1510 1520 1530 1540 1550 1560
1540 1550 1560 1570 1580 1590
pF1KB4 ESDRLRKLMLEWQFQKRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRARLQDEERRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ESDRLRKLMLEWQFQKRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRARLQDEERRR
1570 1580 1590 1600 1610 1620
1600 1610 1620 1630 1640 1650
pF1KB4 QQQLEEMRKREAEDRARQEEERRRQEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QQQLEEMRKREAEDRARQEEERRRQEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAA
1630 1640 1650 1660 1670 1680
1660 1670 1680 1690 1700 1710
pF1KB4 RRLLEPEAPGPNSYPGSTGAAVGAHDACRDAKEKRSKSQDADSPGSSGAPENLTFKERQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RRLLEPEAPGPNSYPGSTGAAVGAHDACRDAKEKRSKSQDADSPGSSGAPENLTFKERQR
1690 1700 1710 1720 1730 1740
1720 1730 1740
pF1KB4 LFSQGQDVSNKVKASRKLTELENELNTK
::::::::::::::::::::::::::::
XP_006 LFSQGQDVSNKVKASRKLTELENELNTK
1750 1760
>>XP_011534144 (OMIM: 159559) PREDICTED: afadin isoform (1758 aa)
initn: 9945 init1: 4247 opt: 8963 Z-score: 3744.9 bits: 706.0 E(85289): 7.5e-202
Smith-Waterman score: 11526; 98.9% identity (98.9% similar) in 1760 aa overlap (1-1743:1-1758)
10 20 30 40 50 60
pF1KB4 MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 RVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGERRLDIDEKPLVVQLNWNKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGERRLDIDEKPLVVQLNWNKD
70 80 90 100 110 120
130 140 150 160 170
pF1KB4 DREGRFVLKNENDAIPPK-AQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQA
:::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::
XP_011 DREGRFVLKNENDAIPPKKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQA
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB4 SDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSS
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB4 DGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIARV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIARV
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB4 MLPPGAQHSDEKGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDHIPKKTKKHLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLPPGAQHSDEKGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDHIPKKTKKHLE
310 320 330 340 350 360
360 370 380 390 400
pF1KB4 GKTPKGKERADGSGYGSTLPPEKLPYLVELSP---------------DGSDSRDKPKLYR
:::::::::::::::::::::::::::::::: :::::::::::::
XP_011 GKTPKGKERADGSGYGSTLPPEKLPYLVELSPGRRNHFAYYNYHTYEDGSDSRDKPKLYR
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB4 LQLSVTEVGTEKLDDNSIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVEGQRISET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQLSVTEVGTEKLDDNSIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVEGQRISET
430 440 450 460 470 480
470 480 490 500 510 520
pF1KB4 TMLQSGMKVQFGASHVFKFVDPSQDHALAKRSVDGGLMVKGPRHKPGIVQETTFDLGGDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TMLQSGMKVQFGASHVFKFVDPSQDHALAKRSVDGGLMVKGPRHKPGIVQETTFDLGGDI
490 500 510 520 530 540
530 540 550 560 570 580
pF1KB4 HSGTALPTSKSTTRLDSDRVSSASSTAERGMVKPMIRVEQQPDYRRQESRTQDASGPELI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSGTALPTSKSTTRLDSDRVSSASSTAERGMVKPMIRVEQQPDYRRQESRTQDASGPELI
550 560 570 580 590 600
590 600 610 620 630 640
pF1KB4 LPASIEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTERT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPASIEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTERT
610 620 630 640 650 660
650 660 670 680 690 700
pF1KB4 HKVIAVVNKMVSMMEGVIQKQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HKVIAVVNKMVSMMEGVIQKQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLA
670 680 690 700 710 720
710 720 730 740 750 760
pF1KB4 HLVQMAFKYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLVQMAFKYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNA
730 740 750 760 770 780
770 780 790 800 810 820
pF1KB4 ALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAAD
790 800 810 820 830 840
830 840 850 860 870 880
pF1KB4 CHLSRIVQATTLLTMDKYAPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CHLSRIVQATTLLTMDKYAPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIE
850 860 870 880 890 900
890 900 910 920 930 940
pF1KB4 NVVTVAENTADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVVTVAENTADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLC
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KB4 QRGFCRLIPHTRSPGTWTIYFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRGFCRLIPHTRSPGTWTIYFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMGL
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KB4 SIVAAKGAGQDKLGIYVKSVVKGGAAD-DGRLAAGDQLLSVDGRSLVGLSQERAAELMTR
::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::
XP_011 SIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTR
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KB4 TSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNGS
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KB4 PESPQLPWAEYSEPKKLPGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAKITSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PESPQLPWAEYSEPKKLPGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAKITSV
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230 1240
pF1KB4 STGNLCTEEQTPPPRPEAYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STGNLCTEEQTPPPRPEAYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMHT
1210 1220 1230 1240 1250 1260
1250 1260 1270 1280 1290 1300
pF1KB4 DSNHSSIAIQRVTRSQEELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSNHSSIAIQRVTRSQEELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQE
1270 1280 1290 1300 1310 1320
1310 1320 1330 1340 1350 1360
pF1KB4 HLNHSSKSVTPASTLTKSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLNHSSKSVTPASTLTKSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDFD
1330 1340 1350 1360 1370 1380
1370 1380 1390 1400 1410 1420
pF1KB4 GMSMDLPLPPPPSANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQERK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GMSMDLPLPPPPSANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQERK
1390 1400 1410 1420 1430 1440
1430 1440 1450 1460 1470 1480
pF1KB4 LGQMRTQSLNPAPFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYITV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGQMRTQSLNPAPFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYITV
1450 1460 1470 1480 1490 1500
1490 1500 1510 1520 1530 1540
pF1KB4 SKEELSSGDSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKEELSSGDSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRKL
1510 1520 1530 1540 1550 1560
1550 1560 1570 1580 1590 1600
pF1KB4 MLEWQFQKRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRARLQDEERRRQQQLEEMR
:::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::
XP_011 MLEWQFQKRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRAR--DEERRRQQQLEEMR
1570 1580 1590 1600 1610
1610 1620 1630 1640 1650 1660
pF1KB4 KREAEDRARQEEERRRQEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLEPEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KREAEDRARQEEERRRQEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLEPEA
1620 1630 1640 1650 1660 1670
1670 1680 1690 1700 1710 1720
pF1KB4 PGPNSYPGSTGAAVGAHDACRDAKEKRSKSQDADSPGSSGAPENLTFKERQRLFSQGQDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGPNSYPGSTGAAVGAHDACRDAKEKRSKSQDADSPGSSGAPENLTFKERQRLFSQGQDV
1680 1690 1700 1710 1720 1730
1730 1740
pF1KB4 SNKVKASRKLTELENELNTK
::::::::::::::::::::
XP_011 SNKVKASRKLTELENELNTK
1740 1750
>>XP_005267053 (OMIM: 159559) PREDICTED: afadin isoform (1824 aa)
initn: 10169 init1: 4247 opt: 8493 Z-score: 3549.2 bits: 669.9 E(85289): 5.9e-191
Smith-Waterman score: 11213; 95.5% identity (95.5% similar) in 1791 aa overlap (1-1710:1-1791)
10 20 30 40 50 60
pF1KB4 MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 RVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGERRLDIDEKPLVVQLNWNKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGERRLDIDEKPLVVQLNWNKD
70 80 90 100 110 120
130 140 150 160 170
pF1KB4 DREGRFVLKNENDAIPPK-AQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQA
:::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::
XP_005 DREGRFVLKNENDAIPPKKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQA
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB4 SDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSS
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB4 DGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIARV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIARV
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB4 MLPPGAQHSDEKGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDHIPKKTKKHLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MLPPGAQHSDEKGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDHIPKKTKKHLE
310 320 330 340 350 360
360 370 380 390 400
pF1KB4 GKTPKGKERADGSGYGSTLPPEKLPYLVELSP---------------DGSDSRDKPKLYR
:::::::::::::::::::::::::::::::: :::::::::::::
XP_005 GKTPKGKERADGSGYGSTLPPEKLPYLVELSPGRRNHFAYYNYHTYEDGSDSRDKPKLYR
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB4 LQLSVTEVGTEKLDDNSIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVEGQRISET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQLSVTEVGTEKLDDNSIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVEGQRISET
430 440 450 460 470 480
470 480 490 500 510 520
pF1KB4 TMLQSGMKVQFGASHVFKFVDPSQDHALAKRSVDGGLMVKGPRHKPGIVQETTFDLGGDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TMLQSGMKVQFGASHVFKFVDPSQDHALAKRSVDGGLMVKGPRHKPGIVQETTFDLGGDI
490 500 510 520 530 540
530 540 550 560 570 580
pF1KB4 HSGTALPTSKSTTRLDSDRVSSASSTAERGMVKPMIRVEQQPDYRRQESRTQDASGPELI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HSGTALPTSKSTTRLDSDRVSSASSTAERGMVKPMIRVEQQPDYRRQESRTQDASGPELI
550 560 570 580 590 600
590 600 610 620 630 640
pF1KB4 LPASIEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTERT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LPASIEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTERT
610 620 630 640 650 660
650 660 670 680 690 700
pF1KB4 HKVIAVVNKMVSMMEGVIQKQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HKVIAVVNKMVSMMEGVIQKQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLA
670 680 690 700 710 720
710 720 730 740 750 760
pF1KB4 HLVQMAFKYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HLVQMAFKYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNA
730 740 750 760 770 780
770 780 790 800 810 820
pF1KB4 ALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAAD
790 800 810 820 830 840
830 840 850 860 870 880
pF1KB4 CHLSRIVQATTLLTMDKYAPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CHLSRIVQATTLLTMDKYAPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIE
850 860 870 880 890 900
890 900 910 920 930 940
pF1KB4 NVVTVAENTADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NVVTVAENTADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLC
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KB4 QRGFCRLIPHTRSPGTWTIYFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QRGFCRLIPHTRSPGTWTIYFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMGL
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KB4 SIVAAKGAGQDKLGIYVKSVVKGGAAD-DGRLAAGDQLLSVDGRSLVGLSQERAAELMTR
::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::
XP_005 SIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTR
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KB4 TSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNGS
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KB4 PESPQLPWAEYSEPKKLPGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAKITSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PESPQLPWAEYSEPKKLPGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAKITSV
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230 1240
pF1KB4 STGNLCTEEQTPPPRPEAYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 STGNLCTEEQTPPPRPEAYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMHT
1210 1220 1230 1240 1250 1260
1250 1260 1270 1280 1290 1300
pF1KB4 DSNHSSIAIQRVTRSQEELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DSNHSSIAIQRVTRSQEELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQE
1270 1280 1290 1300 1310 1320
1310 1320 1330 1340 1350 1360
pF1KB4 HLNHSSKSVTPASTLTKSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HLNHSSKSVTPASTLTKSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDFD
1330 1340 1350 1360 1370 1380
1370 1380 1390 1400 1410 1420
pF1KB4 GMSMDLPLPPPPSANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQERK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GMSMDLPLPPPPSANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQERK
1390 1400 1410 1420 1430 1440
1430 1440 1450 1460 1470 1480
pF1KB4 LGQMRTQSLNPAPFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYITV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LGQMRTQSLNPAPFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYITV
1450 1460 1470 1480 1490 1500
1490 1500 1510 1520 1530 1540
pF1KB4 SKEELSSGDSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SKEELSSGDSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRKL
1510 1520 1530 1540 1550 1560
1550 1560 1570 1580 1590 1600
pF1KB4 MLEWQFQKRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRARLQDEERRRQQQLEEMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MLEWQFQKRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRARLQDEERRRQQQLEEMR
1570 1580 1590 1600 1610 1620
1610 1620 1630 1640 1650 1660
pF1KB4 KREAEDRARQEEERRRQEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLEPEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KREAEDRARQEEERRRQEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLEPEA
1630 1640 1650 1660 1670 1680
pF1KB4 PG----------------------------------------------------------
::
XP_005 PGLCRPPLPRDYEPPSPSPAPGAPPPPPQRNASYLKTQVLSPDSLFTAKFVAYNEEEEEE
1690 1700 1710 1720 1730 1740
1670 1680 1690 1700 1710
pF1KB4 ------PNSYPGSTGAAVGAHDACRDAKEKRSKSQDADSPGSSGAPENLTFKERQRLFSQ
:::::::::::::::::::::::::::::::::::::::::::::
XP_005 DCSLAGPNSYPGSTGAAVGAHDACRDAKEKRSKSQDADSPGSSGAPENLTFKERQRLFSQ
1750 1760 1770 1780 1790 1800
1720 1730 1740
pF1KB4 GQDVSNKVKASRKLTELENELNTK
XP_005 GQDVSNKVKASRKLTELENELNTK
1810 1820
>>XP_016866371 (OMIM: 159559) PREDICTED: afadin isoform (1825 aa)
initn: 10833 init1: 4247 opt: 8493 Z-score: 3549.2 bits: 669.9 E(85289): 5.9e-191
Smith-Waterman score: 11201; 95.4% identity (95.4% similar) in 1792 aa overlap (1-1710:1-1792)
10 20 30 40 50 60
pF1KB4 MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCI
10 20 30 40 50 60
70 80 90 100 110
pF1KB4 RVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGE-RRLDIDEKPLVVQLNWNK
::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::
XP_016 RVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGEERRLDIDEKPLVVQLNWNK
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB4 DDREGRFVLKNENDAIPPK-AQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQ
::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::
XP_016 DDREGRFVLKNENDAIPPKKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQ
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB4 ASDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRS
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB4 SDGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIAR
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB4 VMLPPGAQHSDEKGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDHIPKKTKKHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMLPPGAQHSDEKGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDHIPKKTKKHL
310 320 330 340 350 360
360 370 380 390 400
pF1KB4 EGKTPKGKERADGSGYGSTLPPEKLPYLVELSP---------------DGSDSRDKPKLY
::::::::::::::::::::::::::::::::: ::::::::::::
XP_016 EGKTPKGKERADGSGYGSTLPPEKLPYLVELSPGRRNHFAYYNYHTYEDGSDSRDKPKLY
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB4 RLQLSVTEVGTEKLDDNSIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVEGQRISE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLQLSVTEVGTEKLDDNSIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVEGQRISE
430 440 450 460 470 480
470 480 490 500 510 520
pF1KB4 TTMLQSGMKVQFGASHVFKFVDPSQDHALAKRSVDGGLMVKGPRHKPGIVQETTFDLGGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTMLQSGMKVQFGASHVFKFVDPSQDHALAKRSVDGGLMVKGPRHKPGIVQETTFDLGGD
490 500 510 520 530 540
530 540 550 560 570 580
pF1KB4 IHSGTALPTSKSTTRLDSDRVSSASSTAERGMVKPMIRVEQQPDYRRQESRTQDASGPEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IHSGTALPTSKSTTRLDSDRVSSASSTAERGMVKPMIRVEQQPDYRRQESRTQDASGPEL
550 560 570 580 590 600
590 600 610 620 630 640
pF1KB4 ILPASIEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILPASIEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTER
610 620 630 640 650 660
650 660 670 680 690 700
pF1KB4 THKVIAVVNKMVSMMEGVIQKQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 THKVIAVVNKMVSMMEGVIQKQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVL
670 680 690 700 710 720
710 720 730 740 750 760
pF1KB4 AHLVQMAFKYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHLVQMAFKYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVN
730 740 750 760 770 780
770 780 790 800 810 820
pF1KB4 AALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAA
790 800 810 820 830 840
830 840 850 860 870 880
pF1KB4 DCHLSRIVQATTLLTMDKYAPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DCHLSRIVQATTLLTMDKYAPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLI
850 860 870 880 890 900
890 900 910 920 930 940
pF1KB4 ENVVTVAENTADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENVVTVAENTADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPL
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KB4 CQRGFCRLIPHTRSPGTWTIYFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CQRGFCRLIPHTRSPGTWTIYFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMG
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KB4 LSIVAAKGAGQDKLGIYVKSVVKGGAAD-DGRLAAGDQLLSVDGRSLVGLSQERAAELMT
:::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::
XP_016 LSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMT
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KB4 RTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNG
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KB4 SPESPQLPWAEYSEPKKLPGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAKITS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPESPQLPWAEYSEPKKLPGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAKITS
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230 1240
pF1KB4 VSTGNLCTEEQTPPPRPEAYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSTGNLCTEEQTPPPRPEAYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMH
1210 1220 1230 1240 1250 1260
1250 1260 1270 1280 1290 1300
pF1KB4 TDSNHSSIAIQRVTRSQEELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDSNHSSIAIQRVTRSQEELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQ
1270 1280 1290 1300 1310 1320
1310 1320 1330 1340 1350 1360
pF1KB4 EHLNHSSKSVTPASTLTKSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EHLNHSSKSVTPASTLTKSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDF
1330 1340 1350 1360 1370 1380
1370 1380 1390 1400 1410 1420
pF1KB4 DGMSMDLPLPPPPSANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGMSMDLPLPPPPSANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQER
1390 1400 1410 1420 1430 1440
1430 1440 1450 1460 1470 1480
pF1KB4 KLGQMRTQSLNPAPFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLGQMRTQSLNPAPFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYIT
1450 1460 1470 1480 1490 1500
1490 1500 1510 1520 1530 1540
pF1KB4 VSKEELSSGDSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSKEELSSGDSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRK
1510 1520 1530 1540 1550 1560
1550 1560 1570 1580 1590 1600
pF1KB4 LMLEWQFQKRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRARLQDEERRRQQQLEEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LMLEWQFQKRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRARLQDEERRRQQQLEEM
1570 1580 1590 1600 1610 1620
1610 1620 1630 1640 1650 1660
pF1KB4 RKREAEDRARQEEERRRQEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLEPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKREAEDRARQEEERRRQEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLEPE
1630 1640 1650 1660 1670 1680
pF1KB4 APG---------------------------------------------------------
:::
XP_016 APGLCRPPLPRDYEPPSPSPAPGAPPPPPQRNASYLKTQVLSPDSLFTAKFVAYNEEEEE
1690 1700 1710 1720 1730 1740
1670 1680 1690 1700 1710
pF1KB4 -------PNSYPGSTGAAVGAHDACRDAKEKRSKSQDADSPGSSGAPENLTFKERQRLFS
:::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDCSLAGPNSYPGSTGAAVGAHDACRDAKEKRSKSQDADSPGSSGAPENLTFKERQRLFS
1750 1760 1770 1780 1790 1800
1720 1730 1740
pF1KB4 QGQDVSNKVKASRKLTELENELNTK
XP_016 QGQDVSNKVKASRKLTELENELNTK
1810 1820
>>XP_016866376 (OMIM: 159559) PREDICTED: afadin isoform (1657 aa)
initn: 8056 init1: 4246 opt: 8468 Z-score: 3539.4 bits: 668.0 E(85289): 2.1e-190
Smith-Waterman score: 9931; 94.6% identity (94.6% similar) in 1606 aa overlap (193-1711:20-1625)
170 180 190 200 210 220
pF1KB4 KEKKEKKKREKEALRQASDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMK
::::::::::::::::::::::::::::::
XP_016 MIGKADLFLRMRMTPFLLSENSRLAAEVYKDMPETSFTRTISNPEVVMK
10 20 30 40
230 240 250 260 270 280
pF1KB4 RRRQQKLEKRMQEFRSSDGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRRQQKLEKRMQEFRSSDGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALE
50 60 70 80 90 100
290 300 310 320 330 340
pF1KB4 KYGLEKENPKDYCIARVMLPPGAQHSDEKGAKEIILDDDECPLQIFREWPSDKGILVFQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KYGLEKENPKDYCIARVMLPPGAQHSDEKGAKEIILDDDECPLQIFREWPSDKGILVFQL
110 120 130 140 150 160
350 360 370 380 390
pF1KB4 KRRPPDHIPKKTKKHLEGKTPKGKERADGSGYGSTLPPEKLPYLVELSP-----------
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KRRPPDHIPKKTKKHLEGKTPKGKERADGSGYGSTLPPEKLPYLVELSPGRRNHFAYYNY
170 180 190 200 210 220
400 410 420 430 440
pF1KB4 ----DGSDSRDKPKLYRLQLSVTEVGTEKLDDNSIQLFGPGIQPHHCDLTNMDGVVTVTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HTYEDGSDSRDKPKLYRLQLSVTEVGTEKLDDNSIQLFGPGIQPHHCDLTNMDGVVTVTP
230 240 250 260 270 280
450 460 470 480 490 500
pF1KB4 RSMDAETYVEGQRISETTMLQSGMKVQFGASHVFKFVDPSQDHALAKRSVDGGLMVKGPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSMDAETYVEGQRISETTMLQSGMKVQFGASHVFKFVDPSQDHALAKRSVDGGLMVKGPR
290 300 310 320 330 340
510 520 530 540 550 560
pF1KB4 HKPGIVQETTFDLGGDIHSGTALPTSKSTTRLDSDRVSSASSTAERGMVKPMIRVEQQPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKPGIVQETTFDLGGDIHSGTALPTSKSTTRLDSDRVSSASSTAERGMVKPMIRVEQQPD
350 360 370 380 390 400
570 580 590 600 610 620
pF1KB4 YRRQESRTQDASGPELILPASIEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVLYMACR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YRRQESRTQDASGPELILPASIEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVLYMACR
410 420 430 440 450 460
630 640 650 660 670 680
pF1KB4 YVLSNQYRPDISPTERTHKVIAVVNKMVSMMEGVIQ-------KQKNIAGALAFWMANAS
:::::::::::::::::::::::::::::::::::: :::::::::::::::::
XP_016 YVLSNQYRPDISPTERTHKVIAVVNKMVSMMEGVIQEVDQVDQKQKNIAGALAFWMANAS
470 480 490 500 510 520
690 700 710 720 730 740
pF1KB4 ELLNFIKQDRDLSRITLDAQDVLAHLVQMAFKYLVHCLQSELNNYMPAFLDDPEENSLQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELLNFIKQDRDLSRITLDAQDVLAHLVQMAFKYLVHCLQSELNNYMPAFLDDPEENSLQR
530 540 550 560 570 580
750 760 770 780 790 800
pF1KB4 PKIDDVLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHYWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKIDDVLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHYWG
590 600 610 620 630 640
810 820 830 840 850 860
pF1KB4 AIIRQQLGHIEAWAEKQGLELAADCHLSRIVQATTLLTMDKYAPDDIPNINSTCFKLNSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AIIRQQLGHIEAWAEKQGLELAADCHLSRIVQATTLLTMDKYAPDDIPNINSTCFKLNSL
650 660 670 680 690 700
870 880 890 900 910 920
pF1KB4 QLQALLQNYHCAPDEPFIPTDLIENVVTVAENTADELARSDGREVQLEEDPDLQLPFLLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLQALLQNYHCAPDEPFIPTDLIENVVTVAENTADELARSDGREVQLEEDPDLQLPFLLP
710 720 730 740 750 760
930 940 950 960 970 980
pF1KB4 EDGYSCDVVRNIPNGLQEFLDPLCQRGFCRLIPHTRSPGTWTIYFEGADYESHLLRENTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDGYSCDVVRNIPNGLQEFLDPLCQRGFCRLIPHTRSPGTWTIYFEGADYESHLLRENTE
770 780 790 800 810 820
990 1000 1010 1020 1030
pF1KB4 LAQPLRKEPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAAD-DGRLAAGD
::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::
XP_016 LAQPLRKEPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGD
830 840 850 860 870 880
1040 1050 1060 1070 1080 1090
pF1KB4 QLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISDR
890 900 910 920 930 940
1100 1110 1120 1130 1140 1150
pF1KB4 RGSGKPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEPKKLPGDDRLMKNRADHRSSPNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGSGKPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEPKKLPGDDRLMKNRADHRSSPNV
950 960 970 980 990 1000
1160 1170 1180 1190 1200 1210
pF1KB4 ANQPPSPGGKSAYASGTTAKITSVSTGNLCTEEQTPPPRPEAYPIPTQTYTREYFTFPAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANQPPSPGGKSAYASGTTAKITSVSTGNLCTEEQTPPPRPEAYPIPTQTYTREYFTFPAS
1010 1020 1030 1040 1050 1060
1220 1230 1240 1250 1260 1270
pF1KB4 KSQDRMAPPQNQWPNYEEKPHMHTDSNHSSIAIQRVTRSQEELREDKAYQLERHRIEAAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSQDRMAPPQNQWPNYEEKPHMHTDSNHSSIAIQRVTRSQEELREDKAYQLERHRIEAAM
1070 1080 1090 1100 1110 1120
1280 1290 1300 1310 1320 1330
pF1KB4 DRKSDSDMWINQSSSLDSSTSSQEHLNHSSKSVTPASTLTKSGPGRWKTPAAIPATPVAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRKSDSDMWINQSSSLDSSTSSQEHLNHSSKSVTPASTLTKSGPGRWKTPAAIPATPVAV
1130 1140 1150 1160 1170 1180
1340 1350 1360 1370 1380 1390
pF1KB4 SQPIRTDLPPPPPPPPVHYAGDFDGMSMDLPLPPPPSANQIGLPSAQVAAAERRKREEHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQPIRTDLPPPPPPPPVHYAGDFDGMSMDLPLPPPPSANQIGLPSAQVAAAERRKREEHQ
1190 1200 1210 1220 1230 1240
1400 1410 1420 1430 1440 1450
pF1KB4 RWYEKEKARLEEERERKRREQERKLGQMRTQSLNPAPFSPLTAQQMKPEKPSTLQRPQET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RWYEKEKARLEEERERKRREQERKLGQMRTQSLNPAPFSPLTAQQMKPEKPSTLQRPQET
1250 1260 1270 1280 1290 1300
1460 1470 1480 1490 1500 1510
pF1KB4 VIRELQPQQQPRTIERRDLQYITVSKEELSSGDSLSPDPWKRDAKEKLEKQQQMHIVDML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VIRELQPQQQPRTIERRDLQYITVSKEELSSGDSLSPDPWKRDAKEKLEKQQQMHIVDML
1310 1320 1330 1340 1350 1360
1520 1530 1540 1550 1560 1570
pF1KB4 SKEIQELQSKPDRSAEESDRLRKLMLEWQFQKRLQESKQKDEDDEEEEDDDVDTMLIMQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKEIQELQSKPDRSAEESDRLRKLMLEWQFQKRLQESKQKDEDDEEEEDDDVDTMLIMQR
1370 1380 1390 1400 1410 1420
1580 1590 1600 1610 1620 1630
pF1KB4 LEAERRARLQDEERRRQQQLEEMRKREAEDRARQEEERRRQEEERTKRDAEEKRRQEEGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEAERRARLQDEERRRQQQLEEMRKREAEDRARQEEERRRQEEERTKRDAEEKRRQEEGY
1430 1440 1450 1460 1470 1480
1640 1650 1660
pF1KB4 YSRLEAERRRQHDEAARRLLEPEAPG----------------------------------
::::::::::::::::::::::::::
XP_016 YSRLEAERRRQHDEAARRLLEPEAPGLCRPPLPRDYEPPSPSPAPGAPPPPPQRNASYLK
1490 1500 1510 1520 1530 1540
1670 1680 1690
pF1KB4 ------------------------------PNSYPGSTGAAVGAHDACRDAKEKRSKSQD
::::::::::::::::::::::::::::::
XP_016 TQVLSPDSLFTAKFVAYNEEEEEEDCSLAGPNSYPGSTGAAVGAHDACRDAKEKRSKSQD
1550 1560 1570 1580 1590 1600
1700 1710 1720 1730 1740
pF1KB4 ADSPGSSGAPENLTFKERQRLFSQGQDVSNKVKASRKLTELENELNTK
::::::::::::::::
XP_016 ADSPGSSGAPENLTFKERQRLFSQGQDVSNKVKASRKLTELENELNTK
1610 1620 1630 1640 1650
1743 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 17:00:24 2016 done: Tue Nov 8 17:00:26 2016
Total Scan time: 12.910 Total Display time: 0.770
Function used was FASTA [36.3.4 Apr, 2011]