FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2589, 972 aa 1>>>pF1KE2589 972 - 972 aa - 972 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.4304+/-0.000405; mu= 1.6751+/- 0.025 mean_var=203.3310+/-41.534, 0's: 0 Z-trim(118.4): 29 B-trim: 1527 in 1/52 Lambda= 0.089944 statistics sampled from 31326 (31355) to 31326 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.707), E-opt: 0.2 (0.368), width: 16 Scan time: 10.490 The best scores are: opt bits E(85289) NP_055502 (OMIM: 613516,615705) run domain Beclin- ( 972) 6528 860.6 0 XP_006713891 (OMIM: 613516,615705) PREDICTED: run ( 997) 3939 524.6 9.7e-148 XP_016863033 (OMIM: 613516,615705) PREDICTED: run ( 820) 3773 503.0 2.5e-141 XP_016863034 (OMIM: 613516,615705) PREDICTED: run ( 820) 3773 503.0 2.5e-141 NP_001139114 (OMIM: 613516,615705) run domain Becl ( 927) 3773 503.1 2.8e-141 XP_005269431 (OMIM: 613516,615705) PREDICTED: run ( 987) 3773 503.1 2.9e-141 XP_016863032 (OMIM: 613516,615705) PREDICTED: run ( 830) 2792 375.8 5.3e-103 XP_006713890 (OMIM: 613516,615705) PREDICTED: run (1012) 2782 374.5 1.5e-102 XP_006713893 (OMIM: 613516,615705) PREDICTED: run ( 845) 2605 351.5 1.1e-95 XP_006713894 (OMIM: 613516,615705) PREDICTED: run ( 845) 2605 351.5 1.1e-95 XP_006713892 (OMIM: 613516,615705) PREDICTED: run ( 952) 2605 351.5 1.2e-95 XP_016880943 (OMIM: 611466,611497) PREDICTED: plec ( 531) 485 76.3 4.8e-13 XP_011523830 (OMIM: 611466,611497) PREDICTED: plec ( 535) 485 76.3 4.8e-13 XP_006722264 (OMIM: 611466,611497) PREDICTED: plec ( 926) 485 76.4 7.6e-13 XP_016880942 (OMIM: 611466,611497) PREDICTED: plec ( 926) 485 76.4 7.6e-13 XP_016880941 (OMIM: 611466,611497) PREDICTED: plec ( 967) 485 76.4 7.9e-13 XP_011523828 (OMIM: 611466,611497) PREDICTED: plec ( 989) 485 76.4 8.1e-13 XP_011523827 (OMIM: 611466,611497) PREDICTED: plec (1005) 485 76.4 8.2e-13 NP_055613 (OMIM: 611466,611497) pleckstrin homolog (1056) 485 76.4 8.5e-13 XP_011523825 (OMIM: 611466,611497) PREDICTED: plec (1056) 485 76.4 8.5e-13 XP_011523826 (OMIM: 611466,611497) PREDICTED: plec (1056) 485 76.4 8.5e-13 XP_016880940 (OMIM: 611466,611497) PREDICTED: plec (1056) 485 76.4 8.5e-13 >>NP_055502 (OMIM: 613516,615705) run domain Beclin-1-in (972 aa) initn: 6528 init1: 6528 opt: 6528 Z-score: 4589.2 bits: 860.6 E(85289): 0 Smith-Waterman score: 6528; 100.0% identity (100.0% similar) in 972 aa overlap (1-972:1-972) 10 20 30 40 50 60 pF1KE2 MRPEGAGMELGGGEERLPEESRREHWQLLGNLKTTVEGLVSTNSPNVWSKYGGLERLCRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MRPEGAGMELGGGEERLPEESRREHWQLLGNLKTTVEGLVSTNSPNVWSKYGGLERLCRD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 MQSILYHGLIRDQACRRQTDYWQFVKDIRWLSPHSALHVEKFISVHENDQSSADGASERA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MQSILYHGLIRDQACRRQTDYWQFVKDIRWLSPHSALHVEKFISVHENDQSSADGASERA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 VAELWLQHSLQYHCLSAQLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VAELWLQHSLQYHCLSAQLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 RLLAQIDASMFARKHESPLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RLLAQIDASMFARKHESPLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 GSERRSTSFPLSGPPRKPQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GSERRSTSFPLSGPPRKPQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 SPIEASWVSSQNDSPGDASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SPIEASWVSSQNDSPGDASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KPDSAASSLGDQEGGGESQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KPDSAASSLGDQEGGGESQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 ESCNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ESCNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 QDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 QDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 LRRQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LRRQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIR 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 RNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 LLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYR 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 CAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 CAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 LIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVP 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 GHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDI 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 IFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 IFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAE 910 920 930 940 950 960 970 pF1KE2 ALALEAAVLEAT :::::::::::: NP_055 ALALEAAVLEAT 970 >>XP_006713891 (OMIM: 613516,615705) PREDICTED: run doma (997 aa) initn: 3939 init1: 3939 opt: 3939 Z-score: 2773.3 bits: 524.6 E(85289): 9.7e-148 Smith-Waterman score: 6468; 97.5% identity (97.5% similar) in 997 aa overlap (1-972:1-997) 10 20 30 40 50 60 pF1KE2 MRPEGAGMELGGGEERLPEESRREHWQLLGNLKTTVEGLVSTNSPNVWSKYGGLERLCRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MRPEGAGMELGGGEERLPEESRREHWQLLGNLKTTVEGLVSTNSPNVWSKYGGLERLCRD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 MQSILYHGLIRDQACRRQTDYWQFVKDIRWLSPHSALHVEKFISVHENDQSSADGASERA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MQSILYHGLIRDQACRRQTDYWQFVKDIRWLSPHSALHVEKFISVHENDQSSADGASERA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 VAELWLQHSLQYHCLSAQLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VAELWLQHSLQYHCLSAQLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 RLLAQIDASMFARKHESPLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RLLAQIDASMFARKHESPLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 GSERRSTSFPLSGPPRKPQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GSERRSTSFPLSGPPRKPQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 SPIEASWVSSQNDSPGDASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SPIEASWVSSQNDSPGDASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KPDSAASSLGDQEGGGESQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KPDSAASSLGDQEGGGESQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 ESCNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ESCNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 QDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIR 490 500 510 520 530 540 550 560 570 580 590 pF1KE2 LRRQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQD---- :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LRRQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDGSEG 550 560 570 580 590 600 600 610 620 630 pF1KE2 ---------------------ADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLK ::::::::::::::::::::::::::::::::::::::: XP_006 SNLTHISKNGLSVSLASMFSDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLK 610 620 630 640 650 660 640 650 660 670 680 690 pF1KE2 QFEGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QFEGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAP 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE2 PRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQ 730 740 750 760 770 780 760 770 780 790 800 810 pF1KE2 MAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQ 790 800 810 820 830 840 820 830 840 850 860 870 pF1KE2 LCHMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LCHMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGA 850 860 870 880 890 900 880 890 900 910 920 930 pF1KE2 THVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 THVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERL 910 920 930 940 950 960 940 950 960 970 pF1KE2 QARREALARQSLESYLSDYEEEPAEALALEAAVLEAT ::::::::::::::::::::::::::::::::::::: XP_006 QARREALARQSLESYLSDYEEEPAEALALEAAVLEAT 970 980 990 >>XP_016863033 (OMIM: 613516,615705) PREDICTED: run doma (820 aa) initn: 5367 init1: 3746 opt: 3773 Z-score: 2658.2 bits: 503.0 E(85289): 2.5e-141 Smith-Waterman score: 5341; 98.2% identity (98.2% similar) in 820 aa overlap (168-972:1-820) 140 150 160 170 180 190 pF1KE2 QLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHES :::::::::::::::::::::::::::::: XP_016 MLQCLEAVEQNNPRLLAQIDASMFARKHES 10 20 30 200 210 220 230 240 250 pF1KE2 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK 40 50 60 70 80 90 260 270 280 290 300 310 pF1KE2 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD 100 110 120 130 140 150 320 330 340 350 360 370 pF1KE2 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE 160 170 180 190 200 210 380 390 400 410 420 pF1KE2 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP---------------ES ::::::::::::::::::::::::::::::::::::::::::: :: XP_016 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAES 220 230 240 250 260 270 430 440 450 460 470 480 pF1KE2 CNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQD 280 290 300 310 320 330 490 500 510 520 530 540 pF1KE2 FGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLR 340 350 360 370 380 390 550 560 570 580 590 600 pF1KE2 RQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIRRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIRRN 400 410 420 430 440 450 610 620 630 640 650 660 pF1KE2 TASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLL 460 470 480 490 500 510 670 680 690 700 710 720 pF1KE2 PIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCA 520 530 540 550 560 570 730 740 750 760 770 780 pF1KE2 GCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLI 580 590 600 610 620 630 790 800 810 820 830 840 pF1KE2 KIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGH 640 650 660 670 680 690 850 860 870 880 890 900 pF1KE2 LTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIF 700 710 720 730 740 750 910 920 930 940 950 960 pF1KE2 PFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEAL 760 770 780 790 800 810 970 pF1KE2 ALEAAVLEAT :::::::::: XP_016 ALEAAVLEAT 820 >>XP_016863034 (OMIM: 613516,615705) PREDICTED: run doma (820 aa) initn: 5367 init1: 3746 opt: 3773 Z-score: 2658.2 bits: 503.0 E(85289): 2.5e-141 Smith-Waterman score: 5341; 98.2% identity (98.2% similar) in 820 aa overlap (168-972:1-820) 140 150 160 170 180 190 pF1KE2 QLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHES :::::::::::::::::::::::::::::: XP_016 MLQCLEAVEQNNPRLLAQIDASMFARKHES 10 20 30 200 210 220 230 240 250 pF1KE2 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK 40 50 60 70 80 90 260 270 280 290 300 310 pF1KE2 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD 100 110 120 130 140 150 320 330 340 350 360 370 pF1KE2 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE 160 170 180 190 200 210 380 390 400 410 420 pF1KE2 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP---------------ES ::::::::::::::::::::::::::::::::::::::::::: :: XP_016 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAES 220 230 240 250 260 270 430 440 450 460 470 480 pF1KE2 CNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQD 280 290 300 310 320 330 490 500 510 520 530 540 pF1KE2 FGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLR 340 350 360 370 380 390 550 560 570 580 590 600 pF1KE2 RQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIRRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIRRN 400 410 420 430 440 450 610 620 630 640 650 660 pF1KE2 TASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLL 460 470 480 490 500 510 670 680 690 700 710 720 pF1KE2 PIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCA 520 530 540 550 560 570 730 740 750 760 770 780 pF1KE2 GCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLI 580 590 600 610 620 630 790 800 810 820 830 840 pF1KE2 KIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGH 640 650 660 670 680 690 850 860 870 880 890 900 pF1KE2 LTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIF 700 710 720 730 740 750 910 920 930 940 950 960 pF1KE2 PFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEAL 760 770 780 790 800 810 970 pF1KE2 ALEAAVLEAT :::::::::: XP_016 ALEAAVLEAT 820 >>NP_001139114 (OMIM: 613516,615705) run domain Beclin-1 (927 aa) initn: 6098 init1: 3746 opt: 3773 Z-score: 2657.4 bits: 503.1 E(85289): 2.8e-141 Smith-Waterman score: 6072; 98.4% identity (98.4% similar) in 927 aa overlap (61-972:1-927) 40 50 60 70 80 90 pF1KE2 NLKTTVEGLVSTNSPNVWSKYGGLERLCRDMQSILYHGLIRDQACRRQTDYWQFVKDIRW :::::::::::::::::::::::::::::: NP_001 MQSILYHGLIRDQACRRQTDYWQFVKDIRW 10 20 30 100 110 120 130 140 150 pF1KE2 LSPHSALHVEKFISVHENDQSSADGASERAVAELWLQHSLQYHCLSAQLRPLLGDRQYIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSPHSALHVEKFISVHENDQSSADGASERAVAELWLQHSLQYHCLSAQLRPLLGDRQYIR 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE2 KFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHESPLLVTKSQSLTAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHESPLLVTKSQSLTAL 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE2 PSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRKPQESRGHVSPAED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRKPQESRGHVSPAED 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE2 QTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGDASEGPEYLAIGNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGDASEGPEYLAIGNL 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE2 DPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGESQLSSVLRRSSFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGESQLSSVLRRSSFS 280 290 300 310 320 330 400 410 420 430 pF1KE2 EGQTLTVTSGAKKSHIRSHSDTSIASRGAP---------------ESCNDKAKLRGPLPY :::::::::::::::::::::::::::::: ::::::::::::::: NP_001 EGQTLTVTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAESCNDKAKLRGPLPY 340 350 360 370 380 390 440 450 460 470 480 490 pF1KE2 SGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQDFGSCADLEKENAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQDFGSCADLEKENAH 400 410 420 430 440 450 500 510 520 530 540 550 pF1KE2 FSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLRRQQIRTKNLLPMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLRRQQIRTKNLLPMY 460 470 480 490 500 510 560 570 580 590 600 610 pF1KE2 QEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIRRNTASSSKSFVSSQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIRRNTASSSKSFVSSQS 520 530 540 550 560 570 620 630 640 650 660 670 pF1KE2 FSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDG 580 590 600 610 620 630 680 690 700 710 720 730 pF1KE2 QHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKR 640 650 660 670 680 690 740 750 760 770 780 790 pF1KE2 LRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDI 700 710 720 730 740 750 800 810 820 830 840 850 pF1KE2 NSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDL 760 770 780 790 800 810 860 870 880 890 900 910 pF1KE2 TATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEEC 820 830 840 850 860 870 920 930 940 950 960 970 pF1KE2 KACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEALALEAAVLEAT ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEALALEAAVLEAT 880 890 900 910 920 >>XP_005269431 (OMIM: 613516,615705) PREDICTED: run doma (987 aa) initn: 6514 init1: 3746 opt: 3773 Z-score: 2657.0 bits: 503.1 E(85289): 2.9e-141 Smith-Waterman score: 6488; 98.5% identity (98.5% similar) in 987 aa overlap (1-972:1-987) 10 20 30 40 50 60 pF1KE2 MRPEGAGMELGGGEERLPEESRREHWQLLGNLKTTVEGLVSTNSPNVWSKYGGLERLCRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MRPEGAGMELGGGEERLPEESRREHWQLLGNLKTTVEGLVSTNSPNVWSKYGGLERLCRD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 MQSILYHGLIRDQACRRQTDYWQFVKDIRWLSPHSALHVEKFISVHENDQSSADGASERA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MQSILYHGLIRDQACRRQTDYWQFVKDIRWLSPHSALHVEKFISVHENDQSSADGASERA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 VAELWLQHSLQYHCLSAQLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VAELWLQHSLQYHCLSAQLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 RLLAQIDASMFARKHESPLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RLLAQIDASMFARKHESPLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 GSERRSTSFPLSGPPRKPQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GSERRSTSFPLSGPPRKPQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 SPIEASWVSSQNDSPGDASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SPIEASWVSSQNDSPGDASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KPDSAASSLGDQEGGGESQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KPDSAASSLGDQEGGGESQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP 370 380 390 400 410 420 430 440 450 460 pF1KE2 ---------------ESCNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMF ::::::::::::::::::::::::::::::::::::::::::::: XP_005 GGPRNITIIVEDPIAESCNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMF 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE2 RRPSEGQSLISYLSEQDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RRPSEGQSLISYLSEQDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEE 490 500 510 520 530 540 530 540 550 560 570 580 pF1KE2 EDSDREIQELKQKIRLRRQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EDSDREIQELKQKIRLRRQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGS 550 560 570 580 590 600 590 600 610 620 630 640 pF1KE2 ADEVDEFEIQDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ADEVDEFEIQDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAA 610 620 630 640 650 660 650 660 670 680 690 700 pF1KE2 SELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVH 670 680 690 700 710 720 710 720 730 740 750 760 pF1KE2 PAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRK 730 740 750 760 770 780 770 780 790 800 810 820 pF1KE2 WDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKT 790 800 810 820 830 840 830 840 850 860 870 880 pF1KE2 CRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQ 850 860 870 880 890 900 890 900 910 920 930 940 pF1KE2 AKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQ 910 920 930 940 950 960 950 960 970 pF1KE2 SLESYLSDYEEEPAEALALEAAVLEAT ::::::::::::::::::::::::::: XP_005 SLESYLSDYEEEPAEALALEAAVLEAT 970 980 >>XP_016863032 (OMIM: 613516,615705) PREDICTED: run doma (830 aa) initn: 2792 init1: 2792 opt: 2792 Z-score: 1970.2 bits: 375.8 E(85289): 5.3e-103 Smith-Waterman score: 5321; 97.0% identity (97.0% similar) in 830 aa overlap (168-972:1-830) 140 150 160 170 180 190 pF1KE2 QLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHES :::::::::::::::::::::::::::::: XP_016 MLQCLEAVEQNNPRLLAQIDASMFARKHES 10 20 30 200 210 220 230 240 250 pF1KE2 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK 40 50 60 70 80 90 260 270 280 290 300 310 pF1KE2 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD 100 110 120 130 140 150 320 330 340 350 360 370 pF1KE2 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE 160 170 180 190 200 210 380 390 400 410 420 430 pF1KE2 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAPESCNDKAKLRGPLPYSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAPESCNDKAKLRGPLPYSG 220 230 240 250 260 270 440 450 460 470 480 490 pF1KE2 QSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQDFGSCADLEKENAHFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQDFGSCADLEKENAHFS 280 290 300 310 320 330 500 510 520 530 540 550 pF1KE2 ISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLRRQQIRTKNLLPMYQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLRRQQIRTKNLLPMYQE 340 350 360 370 380 390 560 570 580 590 pF1KE2 AEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQD--------------------- ::::::::::::::::::::::::::::::::::::::: XP_016 AEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDGSEGSNLTHISKNGLSVSLAS 400 410 420 430 440 450 600 610 620 630 640 650 pF1KE2 ----ADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MFSDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLV 460 470 480 490 500 510 660 670 680 690 700 710 pF1KE2 PEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKI 520 530 540 550 560 570 720 730 740 750 760 770 pF1KE2 AVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYY 580 590 600 610 620 630 780 790 800 810 820 830 pF1KE2 VSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKEL 640 650 660 670 680 690 840 850 860 870 880 890 pF1KE2 LDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICE 700 710 720 730 740 750 900 910 920 930 940 950 pF1KE2 FCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQSLESYLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQSLESYLS 760 770 780 790 800 810 960 970 pF1KE2 DYEEEPAEALALEAAVLEAT :::::::::::::::::::: XP_016 DYEEEPAEALALEAAVLEAT 820 830 >>XP_006713890 (OMIM: 613516,615705) PREDICTED: run doma (1012 aa) initn: 5373 init1: 2782 opt: 2782 Z-score: 1961.9 bits: 374.5 E(85289): 1.5e-102 Smith-Waterman score: 6386; 96.0% identity (96.0% similar) in 1004 aa overlap (1-964:1-1004) 10 20 30 40 50 60 pF1KE2 MRPEGAGMELGGGEERLPEESRREHWQLLGNLKTTVEGLVSTNSPNVWSKYGGLERLCRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MRPEGAGMELGGGEERLPEESRREHWQLLGNLKTTVEGLVSTNSPNVWSKYGGLERLCRD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 MQSILYHGLIRDQACRRQTDYWQFVKDIRWLSPHSALHVEKFISVHENDQSSADGASERA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MQSILYHGLIRDQACRRQTDYWQFVKDIRWLSPHSALHVEKFISVHENDQSSADGASERA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 VAELWLQHSLQYHCLSAQLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VAELWLQHSLQYHCLSAQLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 RLLAQIDASMFARKHESPLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RLLAQIDASMFARKHESPLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 GSERRSTSFPLSGPPRKPQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GSERRSTSFPLSGPPRKPQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 SPIEASWVSSQNDSPGDASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SPIEASWVSSQNDSPGDASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KPDSAASSLGDQEGGGESQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KPDSAASSLGDQEGGGESQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP 370 380 390 400 410 420 430 440 450 460 pF1KE2 ---------------ESCNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMF ::::::::::::::::::::::::::::::::::::::::::::: XP_006 GGPRNITIIVEDPIAESCNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMF 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE2 RRPSEGQSLISYLSEQDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RRPSEGQSLISYLSEQDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEE 490 500 510 520 530 540 530 540 550 560 570 580 pF1KE2 EDSDREIQELKQKIRLRRQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EDSDREIQELKQKIRLRRQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGS 550 560 570 580 590 600 590 600 610 620 pF1KE2 ADEVDEFEIQD-------------------------ADIRRNTASSSKSFVSSQSFSHCF ::::::::::: :::::::::::::::::::::::: XP_006 ADEVDEFEIQDGSEGSNLTHISKNGLSVSLASMFSDADIRRNTASSSKSFVSSQSFSHCF 610 620 630 640 650 660 630 640 650 660 670 680 pF1KE2 LHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADI 670 680 690 700 710 720 690 700 710 720 730 740 pF1KE2 YKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCE 730 740 750 760 770 780 750 760 770 780 790 800 pF1KE2 YLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALY 790 800 810 820 830 840 810 820 830 840 850 860 pF1KE2 RKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRK 850 860 870 880 890 900 870 880 890 900 910 920 pF1KE2 GELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYH 910 920 930 940 950 960 930 940 950 960 970 pF1KE2 KACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEALALEAAVLEAT :::::::::::::::::::::::::::::::::::::::::::: XP_006 KACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEALALEAAVLEAT 970 980 990 1000 1010 >>XP_006713893 (OMIM: 613516,615705) PREDICTED: run doma (845 aa) initn: 4226 init1: 2605 opt: 2605 Z-score: 1838.9 bits: 351.5 E(85289): 1.1e-95 Smith-Waterman score: 5281; 95.3% identity (95.3% similar) in 845 aa overlap (168-972:1-845) 140 150 160 170 180 190 pF1KE2 QLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHES :::::::::::::::::::::::::::::: XP_006 MLQCLEAVEQNNPRLLAQIDASMFARKHES 10 20 30 200 210 220 230 240 250 pF1KE2 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK 40 50 60 70 80 90 260 270 280 290 300 310 pF1KE2 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD 100 110 120 130 140 150 320 330 340 350 360 370 pF1KE2 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE 160 170 180 190 200 210 380 390 400 410 420 pF1KE2 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP---------------ES ::::::::::::::::::::::::::::::::::::::::::: :: XP_006 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAES 220 230 240 250 260 270 430 440 450 460 470 480 pF1KE2 CNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQD 280 290 300 310 320 330 490 500 510 520 530 540 pF1KE2 FGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLR 340 350 360 370 380 390 550 560 570 580 590 pF1KE2 RQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQD------ :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDGSEGSN 400 410 420 430 440 450 600 610 620 630 pF1KE2 -------------------ADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQF ::::::::::::::::::::::::::::::::::::::::: XP_006 LTHISKNGLSVSLASMFSDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQF 460 470 480 490 500 510 640 650 660 670 680 690 pF1KE2 EGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPR 520 530 540 550 560 570 700 710 720 730 740 750 pF1KE2 PQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMA 580 590 600 610 620 630 760 770 780 790 800 810 pF1KE2 IPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLC 640 650 660 670 680 690 820 830 840 850 860 870 pF1KE2 HMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATH 700 710 720 730 740 750 880 890 900 910 920 930 pF1KE2 VERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQA 760 770 780 790 800 810 940 950 960 970 pF1KE2 RREALARQSLESYLSDYEEEPAEALALEAAVLEAT ::::::::::::::::::::::::::::::::::: XP_006 RREALARQSLESYLSDYEEEPAEALALEAAVLEAT 820 830 840 >>XP_006713894 (OMIM: 613516,615705) PREDICTED: run doma (845 aa) initn: 4226 init1: 2605 opt: 2605 Z-score: 1838.9 bits: 351.5 E(85289): 1.1e-95 Smith-Waterman score: 5281; 95.3% identity (95.3% similar) in 845 aa overlap (168-972:1-845) 140 150 160 170 180 190 pF1KE2 QLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHES :::::::::::::::::::::::::::::: XP_006 MLQCLEAVEQNNPRLLAQIDASMFARKHES 10 20 30 200 210 220 230 240 250 pF1KE2 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK 40 50 60 70 80 90 260 270 280 290 300 310 pF1KE2 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD 100 110 120 130 140 150 320 330 340 350 360 370 pF1KE2 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE 160 170 180 190 200 210 380 390 400 410 420 pF1KE2 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP---------------ES ::::::::::::::::::::::::::::::::::::::::::: :: XP_006 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAES 220 230 240 250 260 270 430 440 450 460 470 480 pF1KE2 CNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQD 280 290 300 310 320 330 490 500 510 520 530 540 pF1KE2 FGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLR 340 350 360 370 380 390 550 560 570 580 590 pF1KE2 RQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQD------ :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDGSEGSN 400 410 420 430 440 450 600 610 620 630 pF1KE2 -------------------ADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQF ::::::::::::::::::::::::::::::::::::::::: XP_006 LTHISKNGLSVSLASMFSDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQF 460 470 480 490 500 510 640 650 660 670 680 690 pF1KE2 EGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPR 520 530 540 550 560 570 700 710 720 730 740 750 pF1KE2 PQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMA 580 590 600 610 620 630 760 770 780 790 800 810 pF1KE2 IPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLC 640 650 660 670 680 690 820 830 840 850 860 870 pF1KE2 HMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATH 700 710 720 730 740 750 880 890 900 910 920 930 pF1KE2 VERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQA 760 770 780 790 800 810 940 950 960 970 pF1KE2 RREALARQSLESYLSDYEEEPAEALALEAAVLEAT ::::::::::::::::::::::::::::::::::: XP_006 RREALARQSLESYLSDYEEEPAEALALEAAVLEAT 820 830 840 972 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 16:44:02 2016 done: Tue Nov 8 16:44:04 2016 Total Scan time: 10.490 Total Display time: 0.290 Function used was FASTA [36.3.4 Apr, 2011]