FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2646, 2249 aa 1>>>pF1KE2646 2249 - 2249 aa - 2249 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 16.3183+/-0.00051; mu= -23.2290+/- 0.032 mean_var=791.6803+/-165.523, 0's: 0 Z-trim(124.7): 269 B-trim: 370 in 1/58 Lambda= 0.045583 statistics sampled from 46624 (46944) to 46624 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.781), E-opt: 0.2 (0.55), width: 16 Scan time: 26.390 The best scores are: opt bits E(85289) NP_065783 (OMIM: 135900,614556,614562) AT-rich int (2249) 15624 1044.7 0 XP_016866596 (OMIM: 135900,614556,614562) PREDICTE (2256) 13899 931.2 0 NP_059989 (OMIM: 135900,614556,614562) AT-rich int (2236) 12103 813.1 0 XP_016866595 (OMIM: 135900,614556,614562) PREDICTE (2263) 11487 772.6 0 XP_016866594 (OMIM: 135900,614556,614562) PREDICTE (2306) 9284 627.8 4.7e-178 XP_005267126 (OMIM: 135900,614556,614562) PREDICTE (2289) 8761 593.4 1.1e-167 XP_016866593 (OMIM: 135900,614556,614562) PREDICTE (2316) 8705 589.7 1.4e-166 XP_011534286 (OMIM: 135900,614556,614562) PREDICTE (2359) 8663 586.9 9.4e-166 XP_016866592 (OMIM: 135900,614556,614562) PREDICTE (2326) 8622 584.2 6e-165 XP_016866598 (OMIM: 135900,614556,614562) PREDICTE (1539) 8433 571.6 2.5e-161 XP_011534290 (OMIM: 135900,614556,614562) PREDICTE (1336) 8294 562.4 1.2e-158 XP_016866597 (OMIM: 135900,614556,614562) PREDICTE (1551) 5028 347.7 6.3e-94 NP_006006 (OMIM: 603024,614607) AT-rich interactiv (2285) 3736 262.9 3.2e-68 NP_624361 (OMIM: 603024,614607) AT-rich interactiv (2068) 3359 238.1 8.5e-61 NP_000081 (OMIM: 120180,130020,130050) collagen al (1466) 634 58.7 5.8e-07 NP_000079 (OMIM: 114000,120150,130000,130060,16620 (1464) 588 55.7 4.7e-06 NP_001836 (OMIM: 120130,175780,180000,607595,61177 (1669) 563 54.1 1.6e-05 XP_011519350 (OMIM: 120130,175780,180000,607595,61 (1605) 561 54.0 1.7e-05 XP_011508860 (OMIM: 120131,203780) PREDICTED: coll (1654) 552 53.4 2.7e-05 XP_011522643 (OMIM: 114000,120150,130000,130060,16 (1398) 538 52.4 4.5e-05 XP_011536691 (OMIM: 601234) PREDICTED: nascent pol (2078) 509 50.7 0.00023 XP_006719477 (OMIM: 601234) PREDICTED: nascent pol (2082) 509 50.7 0.00023 XP_006719475 (OMIM: 601234) PREDICTED: nascent pol (2082) 509 50.7 0.00023 XP_006719476 (OMIM: 601234) PREDICTED: nascent pol (2082) 509 50.7 0.00023 XP_016858786 (OMIM: 120131,203780) PREDICTED: coll (1651) 471 48.1 0.0011 XP_011526344 (OMIM: 120216) PREDICTED: collagen al (1744) 463 47.6 0.0016 NP_056534 (OMIM: 120216) collagen alpha-3(V) chain (1745) 463 47.6 0.0016 XP_005246334 (OMIM: 104200,120070,141200,203780) P (1635) 460 47.3 0.0018 NP_511040 (OMIM: 120210,614134,614135) collagen al ( 678) 445 46.0 0.0018 XP_016869755 (OMIM: 120215,130000) PREDICTED: coll (1715) 459 47.3 0.0019 NP_001265003 (OMIM: 120215,130000) collagen alpha- (1838) 459 47.3 0.002 NP_000084 (OMIM: 120215,130000) collagen alpha-1(V (1838) 459 47.3 0.002 XP_011517445 (OMIM: 608461,615155) PREDICTED: coll (1353) 453 46.8 0.0021 NP_001842 (OMIM: 120210,614134,614135) collagen al ( 921) 446 46.2 0.0022 NP_057232 (OMIM: 604999) SH3 and multiple ankyrin (2161) 459 47.4 0.0023 XP_006723296 (OMIM: 604999) PREDICTED: SH3 and mul (2161) 459 47.4 0.0023 XP_011525315 (OMIM: 604999) PREDICTED: SH3 and mul (2169) 459 47.4 0.0023 XP_016865740 (OMIM: 120290,184840,215150,277610,60 (1342) 450 46.6 0.0024 XP_011512604 (OMIM: 120290,184840,215150,277610,60 (1365) 450 46.6 0.0024 XP_011517446 (OMIM: 608461,615155) PREDICTED: coll (1352) 449 46.5 0.0025 XP_011512602 (OMIM: 120290,184840,215150,277610,60 (1438) 450 46.6 0.0025 XP_011512601 (OMIM: 120290,184840,215150,277610,60 (1498) 450 46.7 0.0026 XP_011508859 (OMIM: 120131,203780) PREDICTED: coll (1663) 451 46.8 0.0027 NP_542410 (OMIM: 120290,184840,215150,277610,60186 (1629) 450 46.7 0.0028 NP_542412 (OMIM: 120290,184840,215150,277610,60186 (1650) 450 46.7 0.0028 NP_542411 (OMIM: 120290,184840,215150,277610,60186 (1736) 450 46.7 0.0029 XP_016865739 (OMIM: 120290,184840,215150,277610,60 (1736) 450 46.7 0.0029 XP_011517440 (OMIM: 608461,615155) PREDICTED: coll (1858) 450 46.7 0.0031 NP_116277 (OMIM: 608461,615155) collagen alpha-1(X (1860) 450 46.7 0.0031 XP_016874320 (OMIM: 108300,120140,132450,150600,15 (1305) 431 45.4 0.0056 >>NP_065783 (OMIM: 135900,614556,614562) AT-rich interac (2249 aa) initn: 15624 init1: 15624 opt: 15624 Z-score: 5571.0 bits: 1044.7 E(85289): 0 Smith-Waterman score: 15624; 100.0% identity (100.0% similar) in 2249 aa overlap (1-2249:1-2249) 10 20 30 40 50 60 pF1KE2 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAME 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 TGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 TGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 QQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 QQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 SGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 SGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 QLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 QLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 AQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 AQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 GVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 GVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 KPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 KPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPF 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 SPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 SPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPA 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 LSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 LSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTY 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 GPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 GPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMP 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 SAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 SAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSR 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 QGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 QGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPG 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 ESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 ESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFM 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 EERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 EERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE2 LKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 LKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGS 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE2 NSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 NSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPY 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE2 QQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 QQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSN 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE2 LGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 LGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMY 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE2 GPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 GPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQT 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KE2 HGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 HGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMM 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KE2 VPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 VPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQ 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 1620 pF1KE2 RSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 RSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVL 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 pF1KE2 KQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 KQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFL 1630 1640 1650 1660 1670 1680 1690 1700 1710 1720 1730 1740 pF1KE2 ELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 ELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDD 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 1800 pF1KE2 DEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 DEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVV 1750 1760 1770 1780 1790 1800 1810 1820 1830 1840 1850 1860 pF1KE2 DRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 DRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQE 1810 1820 1830 1840 1850 1860 1870 1880 1890 1900 1910 1920 pF1KE2 GKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 GKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLE 1870 1880 1890 1900 1910 1920 1930 1940 1950 1960 1970 1980 pF1KE2 DEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 DEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLIL 1930 1940 1950 1960 1970 1980 1990 2000 2010 2020 2030 2040 pF1KE2 LHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 LHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAY 1990 2000 2010 2020 2030 2040 2050 2060 2070 2080 2090 2100 pF1KE2 TESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 TESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLIL 2050 2060 2070 2080 2090 2100 2110 2120 2130 2140 2150 2160 pF1KE2 ATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 ATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLI 2110 2120 2130 2140 2150 2160 2170 2180 2190 2200 2210 2220 pF1KE2 SFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 SFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEG 2170 2180 2190 2200 2210 2220 2230 2240 pF1KE2 RLLDISISAVLNSLVASVICDVLFQIGQL ::::::::::::::::::::::::::::: NP_065 RLLDISISAVLNSLVASVICDVLFQIGQL 2230 2240 >>XP_016866596 (OMIM: 135900,614556,614562) PREDICTED: A (2256 aa) initn: 8413 init1: 8413 opt: 13899 Z-score: 4957.9 bits: 931.2 E(85289): 0 Smith-Waterman score: 14907; 94.5% identity (94.5% similar) in 2316 aa overlap (1-2249:1-2256) 10 20 30 40 50 60 pF1KE2 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAME 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 TGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 QQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 SGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 QLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 AQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 GVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPG 610 620 630 640 650 660 670 680 690 700 pF1KE2 KPNHEDLNLIQQERPSSLP--------------DLSGSIDDLPTGTEATLSSAVSASGST ::::::::::::::::::: ::::::::::::::::::::::::::: XP_016 KPNHEDLNLIQQERPSSLPVEVLASEDAAFGLKDLSGSIDDLPTGTEATLSSAVSASGST 670 680 690 700 710 720 710 720 730 740 750 760 pF1KE2 SSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPP 730 740 750 760 770 780 770 780 790 800 810 820 pF1KE2 QPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHA ::::::::::::::::::::::::: XP_016 QPPGSQSESSSHPALSQSPMPQERG----------------------------------- 790 800 830 840 850 860 870 880 pF1KE2 GISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQG ::::::::::::::::::::::::::::::::::: XP_016 -------------------------NYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQG 810 820 830 840 890 900 910 920 930 940 pF1KE2 PSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAA 850 860 870 880 890 900 950 960 970 980 990 1000 pF1KE2 AAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNS 910 920 930 940 950 960 1010 1020 1030 1040 pF1KE2 SAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSK--------------------- ::::::::::::::::::::::::::::::::::::::: XP_016 SAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPS 970 980 990 1000 1010 1020 1050 1060 1070 pF1KE2 --------------------------------KSSSSTTTGEKITKVYELGNEPERKLWV :::::::::::::::::::::::::::: XP_016 PMSPSSASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWV 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KE2 DRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGT 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KE2 SSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQ 1150 1160 1170 1180 1190 1200 1200 1210 1220 1230 1240 1250 pF1KE2 TPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNS 1210 1220 1230 1240 1250 1260 1260 1270 1280 1290 1300 1310 pF1KE2 MTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQS 1270 1280 1290 1300 1310 1320 1320 1330 1340 1350 1360 1370 pF1KE2 PSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYK 1330 1340 1350 1360 1370 1380 1380 1390 1400 1410 1420 1430 pF1KE2 RHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQ 1390 1400 1410 1420 1430 1440 1440 1450 1460 1470 1480 1490 pF1KE2 GPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGM 1450 1460 1470 1480 1490 1500 1500 1510 1520 1530 1540 1550 pF1KE2 NRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRA 1510 1520 1530 1540 1550 1560 1560 1570 1580 1590 1600 1610 pF1KE2 PSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSV 1570 1580 1590 1600 1610 1620 1620 1630 1640 1650 1660 1670 pF1KE2 EASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNL 1630 1640 1650 1660 1670 1680 1680 1690 1700 1710 1720 1730 pF1KE2 SQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEE 1690 1700 1710 1720 1730 1740 1740 1750 1760 1770 1780 1790 pF1KE2 DAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVK 1750 1760 1770 1780 1790 1800 1800 1810 1820 1830 1840 1850 pF1KE2 KNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSA 1810 1820 1830 1840 1850 1860 1860 1870 1880 1890 1900 1910 pF1KE2 GRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSH 1870 1880 1890 1900 1910 1920 1920 1930 1940 1950 1960 1970 pF1KE2 RNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVL 1930 1940 1950 1960 1970 1980 1980 1990 2000 2010 2020 2030 pF1KE2 ILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISG 1990 2000 2010 2020 2030 2040 2040 2050 2060 2070 2080 2090 pF1KE2 QLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQD 2050 2060 2070 2080 2090 2100 2100 2110 2120 2130 2140 2150 pF1KE2 NNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQK 2110 2120 2130 2140 2150 2160 2160 2170 2180 2190 2200 2210 pF1KE2 GSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRS 2170 2180 2190 2200 2210 2220 2220 2230 2240 pF1KE2 EFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL :::::::::::::::::::::::::::::::::::: XP_016 EFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL 2230 2240 2250 >>NP_059989 (OMIM: 135900,614556,614562) AT-rich interac (2236 aa) initn: 11473 init1: 11473 opt: 12103 Z-score: 4319.7 bits: 813.1 E(85289): 0 Smith-Waterman score: 15489; 99.4% identity (99.4% similar) in 2249 aa overlap (1-2249:1-2236) 10 20 30 40 50 60 pF1KE2 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAME 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 TGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 TGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 QQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 QQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 SGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 SGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 QLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 QLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 AQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 AQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQ ::::::::::::::::::::::::::::::::::::::: :::::::: NP_059 QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQ-------------MPPQYGQQ 550 560 570 580 610 620 630 640 650 660 pF1KE2 GVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 GVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPG 590 600 610 620 630 640 670 680 690 700 710 720 pF1KE2 KPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 KPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPF 650 660 670 680 690 700 730 740 750 760 770 780 pF1KE2 SPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 SPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPA 710 720 730 740 750 760 790 800 810 820 830 840 pF1KE2 LSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 LSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTY 770 780 790 800 810 820 850 860 870 880 890 900 pF1KE2 GPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 GPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMP 830 840 850 860 870 880 910 920 930 940 950 960 pF1KE2 SAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 SAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSR 890 900 910 920 930 940 970 980 990 1000 1010 1020 pF1KE2 QGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 QGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPG 950 960 970 980 990 1000 1030 1040 1050 1060 1070 1080 pF1KE2 ESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 ESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFM 1010 1020 1030 1040 1050 1060 1090 1100 1110 1120 1130 1140 pF1KE2 EERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 EERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASS 1070 1080 1090 1100 1110 1120 1150 1160 1170 1180 1190 1200 pF1KE2 LKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 LKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGS 1130 1140 1150 1160 1170 1180 1210 1220 1230 1240 1250 1260 pF1KE2 NSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 NSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPY 1190 1200 1210 1220 1230 1240 1270 1280 1290 1300 1310 1320 pF1KE2 QQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 QQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSN 1250 1260 1270 1280 1290 1300 1330 1340 1350 1360 1370 1380 pF1KE2 LGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 LGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMY 1310 1320 1330 1340 1350 1360 1390 1400 1410 1420 1430 1440 pF1KE2 GPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 GPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQT 1370 1380 1390 1400 1410 1420 1450 1460 1470 1480 1490 1500 pF1KE2 HGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 HGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMM 1430 1440 1450 1460 1470 1480 1510 1520 1530 1540 1550 1560 pF1KE2 VPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 VPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQ 1490 1500 1510 1520 1530 1540 1570 1580 1590 1600 1610 1620 pF1KE2 RSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 RSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVL 1550 1560 1570 1580 1590 1600 1630 1640 1650 1660 1670 1680 pF1KE2 KQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 KQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFL 1610 1620 1630 1640 1650 1660 1690 1700 1710 1720 1730 1740 pF1KE2 ELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 ELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDD 1670 1680 1690 1700 1710 1720 1750 1760 1770 1780 1790 1800 pF1KE2 DEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 DEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVV 1730 1740 1750 1760 1770 1780 1810 1820 1830 1840 1850 1860 pF1KE2 DRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 DRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQE 1790 1800 1810 1820 1830 1840 1870 1880 1890 1900 1910 1920 pF1KE2 GKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 GKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLE 1850 1860 1870 1880 1890 1900 1930 1940 1950 1960 1970 1980 pF1KE2 DEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 DEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLIL 1910 1920 1930 1940 1950 1960 1990 2000 2010 2020 2030 2040 pF1KE2 LHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 LHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAY 1970 1980 1990 2000 2010 2020 2050 2060 2070 2080 2090 2100 pF1KE2 TESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 TESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLIL 2030 2040 2050 2060 2070 2080 2110 2120 2130 2140 2150 2160 pF1KE2 ATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 ATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLI 2090 2100 2110 2120 2130 2140 2170 2180 2190 2200 2210 2220 pF1KE2 SFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 SFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEG 2150 2160 2170 2180 2190 2200 2230 2240 pF1KE2 RLLDISISAVLNSLVASVICDVLFQIGQL ::::::::::::::::::::::::::::: NP_059 RLLDISISAVLNSLVASVICDVLFQIGQL 2210 2220 2230 >>XP_016866595 (OMIM: 135900,614556,614562) PREDICTED: A (2263 aa) initn: 10804 init1: 10804 opt: 11487 Z-score: 4100.7 bits: 772.6 E(85289): 0 Smith-Waterman score: 15586; 99.4% identity (99.4% similar) in 2263 aa overlap (1-2249:1-2263) 10 20 30 40 50 60 pF1KE2 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAME 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 TGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 QQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 SGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 QLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 AQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 GVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPG 610 620 630 640 650 660 670 680 690 700 pF1KE2 KPNHEDLNLIQQERPSSLP--------------DLSGSIDDLPTGTEATLSSAVSASGST ::::::::::::::::::: ::::::::::::::::::::::::::: XP_016 KPNHEDLNLIQQERPSSLPVEVLASEDAAFGLKDLSGSIDDLPTGTEATLSSAVSASGST 670 680 690 700 710 720 710 720 730 740 750 760 pF1KE2 SSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPP 730 740 750 760 770 780 770 780 790 800 810 820 pF1KE2 QPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHA 790 800 810 820 830 840 830 840 850 860 870 880 pF1KE2 GISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQG 850 860 870 880 890 900 890 900 910 920 930 940 pF1KE2 PSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAA 910 920 930 940 950 960 950 960 970 980 990 1000 pF1KE2 AAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNS 970 980 990 1000 1010 1020 1010 1020 1030 1040 1050 1060 pF1KE2 SAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNE 1030 1040 1050 1060 1070 1080 1070 1080 1090 1100 1110 1120 pF1KE2 PERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELA 1090 1100 1110 1120 1130 1140 1130 1140 1150 1160 1170 1180 pF1KE2 TNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANS 1150 1160 1170 1180 1190 1200 1190 1200 1210 1220 1230 1240 pF1KE2 GSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDS 1210 1220 1230 1240 1250 1260 1250 1260 1270 1280 1290 1300 pF1KE2 SFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSM 1270 1280 1290 1300 1310 1320 1310 1320 1330 1340 1350 1360 pF1KE2 QDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLY 1330 1340 1350 1360 1370 1380 1370 1380 1390 1400 1410 1420 pF1KE2 PQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYP 1390 1400 1410 1420 1430 1440 1430 1440 1450 1460 1470 1480 pF1KE2 YSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQ 1450 1460 1470 1480 1490 1500 1490 1500 1510 1520 1530 1540 pF1KE2 APPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSL 1510 1520 1530 1540 1550 1560 1550 1560 1570 1580 1590 1600 pF1KE2 PNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREI 1570 1580 1590 1600 1610 1620 1610 1620 1630 1640 1650 1660 pF1KE2 TFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDS 1630 1640 1650 1660 1670 1680 1670 1680 1690 1700 1710 1720 pF1KE2 TVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLAD 1690 1700 1710 1720 1730 1740 1730 1740 1750 1760 1770 1780 pF1KE2 DSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDK 1750 1760 1770 1780 1790 1800 1790 1800 1810 1820 1830 1840 pF1KE2 LPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRP 1810 1820 1830 1840 1850 1860 1850 1860 1870 1880 1890 1900 pF1KE2 PPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFG 1870 1880 1890 1900 1910 1920 1910 1920 1930 1940 1950 1960 pF1KE2 IQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMS 1930 1940 1950 1960 1970 1980 1970 1980 1990 2000 2010 2020 pF1KE2 KHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLV 1990 2000 2010 2020 2030 2040 2030 2040 2050 2060 2070 2080 pF1KE2 TLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETL 2050 2060 2070 2080 2090 2100 2090 2100 2110 2120 2130 2140 pF1KE2 CKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAA 2110 2120 2130 2140 2150 2160 2150 2160 2170 2180 2190 2200 pF1KE2 RAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMA 2170 2180 2190 2200 2210 2220 2210 2220 2230 2240 pF1KE2 RVDENRSEFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL ::::::::::::::::::::::::::::::::::::::::::: XP_016 RVDENRSEFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL 2230 2240 2250 2260 >>XP_016866594 (OMIM: 135900,614556,614562) PREDICTED: A (2306 aa) initn: 13651 init1: 8821 opt: 9284 Z-score: 3317.6 bits: 627.8 E(85289): 4.7e-178 Smith-Waterman score: 15337; 97.5% identity (97.5% similar) in 2281 aa overlap (26-2249:26-2306) 10 20 30 40 50 60 pF1KE2 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAME ::::::::::::::::::::::::::::::::::: XP_016 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAME 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 TGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 QQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 SGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 QLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 AQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 GVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPG 610 620 630 640 650 660 670 680 690 700 pF1KE2 KPNHEDLNLIQQERPSSLP--------------DLSGSIDDLPTGTEATLSSAVSASGST ::::::::::::::::::: ::::::::::::::::::::::::::: XP_016 KPNHEDLNLIQQERPSSLPVEVLASEDAAFGLKDLSGSIDDLPTGTEATLSSAVSASGST 670 680 690 700 710 720 710 720 730 740 750 760 pF1KE2 SSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPP 730 740 750 760 770 780 770 780 790 800 810 820 pF1KE2 QPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHA 790 800 810 820 830 840 830 840 850 860 870 880 pF1KE2 GISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQG 850 860 870 880 890 900 890 900 910 920 930 940 pF1KE2 PSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAA 910 920 930 940 950 960 950 960 pF1KE2 AAVMQAAANSAQSR-------------------------------------------QGS :::::::::::::: ::: XP_016 AAVMQAAANSAQSRPPYIRSPAYPSQSGAGGRPMFSSQHPNYGNSQAPMVHQPDQYGQGS 970 980 990 1000 1010 1020 970 980 990 1000 1010 1020 pF1KE2 FPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESK 1030 1040 1050 1060 1070 1080 1030 1040 1050 1060 1070 1080 pF1KE2 LPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEER 1090 1100 1110 1120 1130 1140 1090 1100 1110 1120 1130 1140 pF1KE2 GSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKK 1150 1160 1170 1180 1190 1200 1150 1160 1170 1180 1190 1200 pF1KE2 QYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSM 1210 1220 1230 1240 1250 1260 1210 1220 1230 1240 1250 1260 pF1KE2 AEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQG 1270 1280 1290 1300 1310 1320 1270 1280 1290 1300 1310 1320 pF1KE2 MSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGM 1330 1340 1350 1360 1370 1380 1330 1340 1350 1360 1370 1380 pF1KE2 GQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPP 1390 1400 1410 1420 1430 1440 1390 1400 1410 1420 1430 1440 pF1KE2 AKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGI 1450 1460 1470 1480 1490 1500 1450 1460 1470 1480 1490 1500 pF1KE2 PPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPD 1510 1520 1530 1540 1550 1560 1510 1520 1530 1540 1550 1560 pF1KE2 QRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSL 1570 1580 1590 1600 1610 1620 1570 1580 1590 1600 1610 1620 pF1KE2 ENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQR 1630 1640 1650 1660 1670 1680 1630 1640 1650 1660 1670 1680 pF1KE2 RKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELL 1690 1700 1710 1720 1730 1740 1690 1700 1710 1720 1730 1740 pF1KE2 VEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEE 1750 1760 1770 1780 1790 1800 1750 1760 1770 1780 1790 1800 pF1KE2 DEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRS 1810 1820 1830 1840 1850 1860 1810 1820 1830 1840 1850 1860 pF1KE2 DKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKG 1870 1880 1890 1900 1910 1920 1870 1880 1890 1900 1910 1920 pF1KE2 DSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEP 1930 1940 1950 1960 1970 1980 1930 1940 1950 1960 1970 1980 pF1KE2 RSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHH 1990 2000 2010 2020 2030 2040 1990 2000 2010 2020 2030 2040 pF1KE2 EHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTES 2050 2060 2070 2080 2090 2100 2050 2060 2070 2080 2090 2100 pF1KE2 ICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATP 2110 2120 2130 2140 2150 2160 2110 2120 2130 2140 2150 2160 pF1KE2 PFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFL 2170 2180 2190 2200 2210 2220 2170 2180 2190 2200 2210 2220 pF1KE2 EDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLL 2230 2240 2250 2260 2270 2280 2230 2240 pF1KE2 DISISAVLNSLVASVICDVLFQIGQL :::::::::::::::::::::::::: XP_016 DISISAVLNSLVASVICDVLFQIGQL 2290 2300 >>XP_005267126 (OMIM: 135900,614556,614562) PREDICTED: A (2289 aa) initn: 12352 init1: 8264 opt: 8761 Z-score: 3131.8 bits: 593.4 E(85289): 1.1e-167 Smith-Waterman score: 15321; 97.1% identity (97.1% similar) in 2294 aa overlap (9-2249:9-2289) 10 20 30 40 50 60 pF1KE2 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAME :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAME 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 TGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 QQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 SGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 QLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 AQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQ ::::::::::::::::::::::::::::::::::::::: :::::::: XP_005 QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQ-------------MPPQYGQQ 550 560 570 580 610 620 630 640 650 660 pF1KE2 GVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPG 590 600 610 620 630 640 670 680 690 700 710 720 pF1KE2 KPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPF 650 660 670 680 690 700 730 740 750 760 770 780 pF1KE2 SPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPA 710 720 730 740 750 760 790 800 810 820 830 840 pF1KE2 LSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTY 770 780 790 800 810 820 850 860 870 880 890 900 pF1KE2 GPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMP 830 840 850 860 870 880 910 920 930 940 950 960 pF1KE2 SAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSR 890 900 910 920 930 940 970 980 990 1000 1010 1020 pF1KE2 QGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPG 950 960 970 980 990 1000 1030 1040 pF1KE2 ESKLPLPLKADGKEEGTPQPESKSK----------------------------------- ::::::::::::::::::::::::: XP_005 ESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHG 1010 1020 1030 1040 1050 1060 1050 1060 1070 1080 pF1KE2 ------------------KSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPV :::::::::::::::::::::::::::::::::::::::::: XP_005 DESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPV 1070 1080 1090 1100 1110 1120 1090 1100 1110 1120 1130 1140 pF1KE2 SSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQ 1130 1140 1150 1160 1170 1180 1150 1160 1170 1180 1190 1200 pF1KE2 YLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVP 1190 1200 1210 1220 1230 1240 1210 1220 1230 1240 1250 1260 pF1KE2 GDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMP 1250 1260 1270 1280 1290 1300 1270 1280 1290 1300 1310 1320 pF1KE2 DVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQ 1310 1320 1330 1340 1350 1360 1330 1340 1350 1360 1370 1380 pF1KE2 QFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRH 1370 1380 1390 1400 1410 1420 1390 1400 1410 1420 1430 1440 pF1KE2 EGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQM 1430 1440 1450 1460 1470 1480 1450 1460 1470 1480 1490 1500 pF1KE2 MGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRIN 1490 1500 1510 1520 1530 1540 1510 1520 1530 1540 1550 1560 pF1KE2 HESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRM 1550 1560 1570 1580 1590 1600 1570 1580 1590 1600 1610 1620 pF1KE2 SPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKIT 1610 1620 1630 1640 1650 1660 1630 1640 1650 1660 1670 1680 pF1KE2 SKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYF 1670 1680 1690 1700 1710 1720 1690 1700 1710 1720 1730 1740 pF1KE2 RKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEED 1730 1740 1750 1760 1770 1780 1750 1760 1770 1780 1790 1800 pF1KE2 EEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLG 1790 1800 1810 1820 1830 1840 1810 1820 1830 1840 1850 1860 pF1KE2 RVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEE 1850 1860 1870 1880 1890 1900 1870 1880 1890 1900 1910 1920 pF1KE2 QQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRD 1910 1920 1930 1940 1950 1960 1930 1940 1950 1960 1970 1980 pF1KE2 ETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPE 1970 1980 1990 2000 2010 2020 1990 2000 2010 2020 2030 2040 pF1KE2 RKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLP 2030 2040 2050 2060 2070 2080 2050 2060 2070 2080 2090 2100 pF1KE2 ILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSR 2090 2100 2110 2120 2130 2140 2110 2120 2130 2140 2150 2160 pF1KE2 QEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGV 2150 2160 2170 2180 2190 2200 2170 2180 2190 2200 2210 2220 pF1KE2 TMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISI 2210 2220 2230 2240 2250 2260 2230 2240 pF1KE2 SAVLNSLVASVICDVLFQIGQL :::::::::::::::::::::: XP_005 SAVLNSLVASVICDVLFQIGQL 2270 2280 >>XP_016866593 (OMIM: 135900,614556,614562) PREDICTED: A (2316 aa) initn: 13094 init1: 8264 opt: 8705 Z-score: 3111.8 bits: 589.7 E(85289): 1.4e-166 Smith-Waterman score: 15259; 97.1% identity (97.1% similar) in 2281 aa overlap (36-2249:36-2316) 10 20 30 40 50 60 pF1KE2 GAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLP :::::::::::::::::::::::::::::: XP_016 GAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 QQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 DDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 GRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 AGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 GVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 PSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 ASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPY 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 PGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQGVSGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQGVSGY 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 CQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHE 610 620 630 640 650 660 670 680 690 700 710 pF1KE2 DLNLIQQERPSSLP--------------DLSGSIDDLPTGTEATLSSAVSASGSTSSQGD :::::::::::::: :::::::::::::::::::::::::::::::: XP_016 DLNLIQQERPSSLPVEVLASEDAAFGLKDLSGSIDDLPTGTEATLSSAVSASGSTSSQGD 670 680 690 700 710 720 720 730 740 750 760 770 pF1KE2 QSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGS 730 740 750 760 770 780 780 790 800 810 820 830 pF1KE2 QSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSF 790 800 810 820 830 840 840 850 860 870 880 890 pF1KE2 QQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPC 850 860 870 880 890 900 900 910 920 930 940 950 pF1KE2 GAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQ 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KE2 AAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASV 970 980 990 1000 1010 1020 1020 1030 1040 pF1KE2 GLADMMSPGESKLPLPLKADGKEEGTPQPESKSK-------------------------- :::::::::::::::::::::::::::::::::: XP_016 GLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPS 1030 1040 1050 1060 1070 1080 1050 1060 1070 pF1KE2 ---------------------------KSSSSTTTGEKITKVYELGNEPERKLWVDRYLT ::::::::::::::::::::::::::::::::: XP_016 SASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLT 1090 1100 1110 1120 1130 1140 1080 1090 1100 1110 1120 1130 pF1KE2 FMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAA 1150 1160 1170 1180 1190 1200 1140 1150 1160 1170 1180 1190 pF1KE2 SSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQST 1210 1220 1230 1240 1250 1260 1200 1210 1220 1230 1240 1250 pF1KE2 GSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNA 1270 1280 1290 1300 1310 1320 1260 1270 1280 1290 1300 1310 pF1KE2 PYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAM 1330 1340 1350 1360 1370 1380 1320 1330 1340 1350 1360 1370 pF1KE2 SNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDG 1390 1400 1410 1420 1430 1440 1380 1390 1400 1410 1420 1430 pF1KE2 MYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQI 1450 1460 1470 1480 1490 1500 1440 1450 1460 1470 1480 1490 pF1KE2 QTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDD 1510 1520 1530 1540 1550 1560 1500 1510 1520 1530 1540 1550 pF1KE2 MMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPAS 1570 1580 1590 1600 1610 1620 1560 1570 1580 1590 1600 1610 pF1KE2 FQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQP 1630 1640 1650 1660 1670 1680 1620 1630 1640 1650 1660 1670 pF1KE2 VLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSG 1690 1700 1710 1720 1730 1740 1680 1690 1700 1710 1720 1730 pF1KE2 FLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECI 1750 1760 1770 1780 1790 1800 1740 1750 1760 1770 1780 1790 pF1KE2 DDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLF 1810 1820 1830 1840 1850 1860 1800 1810 1820 1830 1840 1850 pF1KE2 VVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKE 1870 1880 1890 1900 1910 1920 1860 1870 1880 1890 1900 1910 pF1KE2 QEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKL 1930 1940 1950 1960 1970 1980 1920 1930 1940 1950 1960 1970 pF1KE2 LEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKL 1990 2000 2010 2020 2030 2040 1980 1990 2000 2010 2020 2030 pF1KE2 ILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLS 2050 2060 2070 2080 2090 2100 2040 2050 2060 2070 2080 2090 pF1KE2 AYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDL 2110 2120 2130 2140 2150 2160 2100 2110 2120 2130 2140 2150 pF1KE2 ILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGN 2170 2180 2190 2200 2210 2220 2160 2170 2180 2190 2200 2210 pF1KE2 LISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLH 2230 2240 2250 2260 2270 2280 2220 2230 2240 pF1KE2 EGRLLDISISAVLNSLVASVICDVLFQIGQL ::::::::::::::::::::::::::::::: XP_016 EGRLLDISISAVLNSLVASVICDVLFQIGQL 2290 2300 2310 >>XP_011534286 (OMIM: 135900,614556,614562) PREDICTED: A (2359 aa) initn: 13094 init1: 8264 opt: 8663 Z-score: 3096.8 bits: 586.9 E(85289): 9.4e-166 Smith-Waterman score: 14908; 95.2% identity (95.2% similar) in 2281 aa overlap (79-2249:79-2359) 50 60 70 80 90 100 pF1KE2 SSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQ :::::::::::::::::::::::::::::: XP_011 SSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQ 50 60 70 80 90 100 110 120 130 140 150 160 pF1KE2 QLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAG 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE2 GQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVP 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE2 EFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHE 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE2 GYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAA 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE2 AAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQ 350 360 370 380 390 400 410 420 430 440 450 460 pF1KE2 NQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQ 410 420 430 440 450 460 470 480 490 500 510 520 pF1KE2 AAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQL 470 480 490 500 510 520 530 540 550 560 570 580 pF1KE2 YGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKE 530 540 550 560 570 580 590 600 610 620 630 640 pF1KE2 TFWLMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TFWLMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEG 590 600 610 620 630 640 650 660 670 680 690 pF1KE2 YGTRSQPPLAPGKPNHEDLNLIQQERPSSLP--------------DLSGSIDDLPTGTEA ::::::::::::::::::::::::::::::: ::::::::::::::: XP_011 YGTRSQPPLAPGKPNHEDLNLIQQERPSSLPVEVLASEDAAFGLKDLSGSIDDLPTGTEA 650 660 670 680 690 700 700 710 720 730 740 750 pF1KE2 TLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPI 710 720 730 740 750 760 760 770 780 790 800 810 pF1KE2 SPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSM 770 780 790 800 810 820 820 830 840 850 860 870 pF1KE2 SPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGM 830 840 850 860 870 880 880 890 900 910 920 930 pF1KE2 GISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPP 890 900 910 920 930 940 940 950 960 pF1KE2 MPTVNRKAQEAAAAVMQAAANSAQSR---------------------------------- :::::::::::::::::::::::::: XP_011 MPTVNRKAQEAAAAVMQAAANSAQSRPPYIRSPAYPSQSGAGGRPMFSSQHPNYGNSQAP 950 960 970 980 990 1000 970 980 990 1000 1010 pF1KE2 ---------QGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASV ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MVHQPDQYGQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASV 1010 1020 1030 1040 1050 1060 1020 1030 1040 pF1KE2 GLADMMSPGESKLPLPLKADGKEEGTPQPESKSK-------------------------- :::::::::::::::::::::::::::::::::: XP_011 GLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPS 1070 1080 1090 1100 1110 1120 1050 1060 1070 pF1KE2 ---------------------------KSSSSTTTGEKITKVYELGNEPERKLWVDRYLT ::::::::::::::::::::::::::::::::: XP_011 SASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLT 1130 1140 1150 1160 1170 1180 1080 1090 1100 1110 1120 1130 pF1KE2 FMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAA 1190 1200 1210 1220 1230 1240 1140 1150 1160 1170 1180 1190 pF1KE2 SSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQST 1250 1260 1270 1280 1290 1300 1200 1210 1220 1230 1240 1250 pF1KE2 GSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNA 1310 1320 1330 1340 1350 1360 1260 1270 1280 1290 1300 1310 pF1KE2 PYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAM 1370 1380 1390 1400 1410 1420 1320 1330 1340 1350 1360 1370 pF1KE2 SNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDG 1430 1440 1450 1460 1470 1480 1380 1390 1400 1410 1420 1430 pF1KE2 MYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQI 1490 1500 1510 1520 1530 1540 1440 1450 1460 1470 1480 1490 pF1KE2 QTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDD 1550 1560 1570 1580 1590 1600 1500 1510 1520 1530 1540 1550 pF1KE2 MMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPAS 1610 1620 1630 1640 1650 1660 1560 1570 1580 1590 1600 1610 pF1KE2 FQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQP 1670 1680 1690 1700 1710 1720 1620 1630 1640 1650 1660 1670 pF1KE2 VLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSG 1730 1740 1750 1760 1770 1780 1680 1690 1700 1710 1720 1730 pF1KE2 FLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECI 1790 1800 1810 1820 1830 1840 1740 1750 1760 1770 1780 1790 pF1KE2 DDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLF 1850 1860 1870 1880 1890 1900 1800 1810 1820 1830 1840 1850 pF1KE2 VVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKE 1910 1920 1930 1940 1950 1960 1860 1870 1880 1890 1900 1910 pF1KE2 QEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKL 1970 1980 1990 2000 2010 2020 1920 1930 1940 1950 1960 1970 pF1KE2 LEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKL 2030 2040 2050 2060 2070 2080 1980 1990 2000 2010 2020 2030 pF1KE2 ILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLS 2090 2100 2110 2120 2130 2140 2040 2050 2060 2070 2080 2090 pF1KE2 AYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDL 2150 2160 2170 2180 2190 2200 2100 2110 2120 2130 2140 2150 pF1KE2 ILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGN 2210 2220 2230 2240 2250 2260 2160 2170 2180 2190 2200 2210 pF1KE2 LISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLH 2270 2280 2290 2300 2310 2320 2220 2230 2240 pF1KE2 EGRLLDISISAVLNSLVASVICDVLFQIGQL ::::::::::::::::::::::::::::::: XP_011 EGRLLDISISAVLNSLVASVICDVLFQIGQL 2330 2340 2350 >>XP_016866592 (OMIM: 135900,614556,614562) PREDICTED: A (2326 aa) initn: 13094 init1: 8264 opt: 8622 Z-score: 3082.3 bits: 584.2 E(85289): 6e-165 Smith-Waterman score: 15179; 96.6% identity (96.6% similar) in 2281 aa overlap (46-2249:46-2326) 20 30 40 50 60 70 pF1KE2 AKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEA :::::::::::::::::::::::::::::: XP_016 AKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEA 20 30 40 50 60 70 80 90 100 110 120 130 pF1KE2 PAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPIS 80 90 100 110 120 130 140 150 160 170 180 190 pF1KE2 NNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEP 140 150 160 170 180 190 200 210 220 230 240 250 pF1KE2 AGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQH 200 210 220 230 240 250 260 270 280 290 300 310 pF1KE2 GGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGG 260 270 280 290 300 310 320 330 340 350 360 370 pF1KE2 GGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQG 320 330 340 350 360 370 380 390 400 410 420 430 pF1KE2 GGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGG 380 390 400 410 420 430 440 450 460 470 480 490 pF1KE2 SYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQ 440 450 460 470 480 490 500 510 520 530 540 550 pF1KE2 RSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGP 500 510 520 530 540 550 560 570 580 590 600 610 pF1KE2 QRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQGVSGYCQQGQQPYYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQGVSGYCQQGQQPYYS 560 570 580 590 600 610 620 630 640 650 660 670 pF1KE2 QQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERP 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 SSLP--------------DLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFS :::: :::::::::::::::::::::::::::::::::::::::::: XP_016 SSLPVEVLASEDAAFGLKDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFS 680 690 700 710 720 730 730 740 750 760 770 780 pF1KE2 PHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPAL 740 750 760 770 780 790 790 800 810 820 830 840 pF1KE2 SQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYG 800 810 820 830 840 850 850 860 870 880 890 900 pF1KE2 PQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPS 860 870 880 890 900 910 910 920 930 940 950 960 pF1KE2 AGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSR- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRY 920 930 940 950 960 970 970 980 990 1000 1010 pF1KE2 ---------QGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASV ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ATQEHAPGRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASV 980 990 1000 1010 1020 1030 1020 1030 1040 pF1KE2 GLADMMSPGESKLPLPLKADGKEEGTPQPESKSK-------------------------- :::::::::::::::::::::::::::::::::: XP_016 GLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPS 1040 1050 1060 1070 1080 1090 1050 1060 1070 pF1KE2 ---------------------------KSSSSTTTGEKITKVYELGNEPERKLWVDRYLT ::::::::::::::::::::::::::::::::: XP_016 SASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLT 1100 1110 1120 1130 1140 1150 1080 1090 1100 1110 1120 1130 pF1KE2 FMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAA 1160 1170 1180 1190 1200 1210 1140 1150 1160 1170 1180 1190 pF1KE2 SSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQST 1220 1230 1240 1250 1260 1270 1200 1210 1220 1230 1240 1250 pF1KE2 GSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNA 1280 1290 1300 1310 1320 1330 1260 1270 1280 1290 1300 1310 pF1KE2 PYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAM 1340 1350 1360 1370 1380 1390 1320 1330 1340 1350 1360 1370 pF1KE2 SNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDG 1400 1410 1420 1430 1440 1450 1380 1390 1400 1410 1420 1430 pF1KE2 MYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQI 1460 1470 1480 1490 1500 1510 1440 1450 1460 1470 1480 1490 pF1KE2 QTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDD 1520 1530 1540 1550 1560 1570 1500 1510 1520 1530 1540 1550 pF1KE2 MMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPAS 1580 1590 1600 1610 1620 1630 1560 1570 1580 1590 1600 1610 pF1KE2 FQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQP 1640 1650 1660 1670 1680 1690 1620 1630 1640 1650 1660 1670 pF1KE2 VLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSG 1700 1710 1720 1730 1740 1750 1680 1690 1700 1710 1720 1730 pF1KE2 FLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECI 1760 1770 1780 1790 1800 1810 1740 1750 1760 1770 1780 1790 pF1KE2 DDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLF 1820 1830 1840 1850 1860 1870 1800 1810 1820 1830 1840 1850 pF1KE2 VVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKE 1880 1890 1900 1910 1920 1930 1860 1870 1880 1890 1900 1910 pF1KE2 QEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKL 1940 1950 1960 1970 1980 1990 1920 1930 1940 1950 1960 1970 pF1KE2 LEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKL 2000 2010 2020 2030 2040 2050 1980 1990 2000 2010 2020 2030 pF1KE2 ILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLS 2060 2070 2080 2090 2100 2110 2040 2050 2060 2070 2080 2090 pF1KE2 AYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDL 2120 2130 2140 2150 2160 2170 2100 2110 2120 2130 2140 2150 pF1KE2 ILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGN 2180 2190 2200 2210 2220 2230 2160 2170 2180 2190 2200 2210 pF1KE2 LISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLH 2240 2250 2260 2270 2280 2290 2220 2230 2240 pF1KE2 EGRLLDISISAVLNSLVASVICDVLFQIGQL ::::::::::::::::::::::::::::::: XP_016 EGRLLDISISAVLNSLVASVICDVLFQIGQL 2300 2310 2320 >>XP_016866598 (OMIM: 135900,614556,614562) PREDICTED: A (1539 aa) initn: 8264 init1: 8264 opt: 8433 Z-score: 3017.5 bits: 571.6 E(85289): 2.5e-161 Smith-Waterman score: 10107; 96.6% identity (96.6% similar) in 1539 aa overlap (764-2249:1-1539) 740 750 760 770 780 790 pF1KE2 GPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFM :::::::::::::::::::::::::::::: XP_016 MPPQPPGSQSESSSHPALSQSPMPQERGFM 10 20 30 800 810 820 830 840 850 pF1KE2 AGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNY 40 50 60 70 80 90 860 870 880 890 900 910 pF1KE2 SRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNM 100 110 120 130 140 150 920 930 940 950 960 970 pF1KE2 SSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLM 160 170 180 190 200 210 980 990 1000 1010 1020 1030 pF1KE2 ASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGK 220 230 240 250 260 270 1040 pF1KE2 EEGTPQPESKSK------------------------------------------------ :::::::::::: XP_016 EEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPK 280 290 300 310 320 330 1050 1060 1070 1080 1090 1100 pF1KE2 -----KSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDL 340 350 360 370 380 390 1110 1120 1130 1140 1150 1160 pF1KE2 FRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGE 400 410 420 430 440 450 1170 1180 1190 1200 1210 1220 pF1KE2 EPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPH 460 470 480 490 500 510 1230 1240 1250 1260 1270 1280 pF1KE2 GQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKD 520 530 540 550 560 570 1290 1300 1310 1320 1330 1340 pF1KE2 PFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHE 580 590 600 610 620 630 1350 1360 1370 1380 1390 1400 pF1KE2 PYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQ 640 650 660 670 680 690 1410 1420 1430 1440 1450 1460 pF1KE2 QEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGP 700 710 720 730 740 750 1470 1480 1490 1500 1510 1520 pF1KE2 QQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQ 760 770 780 790 800 810 1530 1540 1550 1560 1570 1580 pF1KE2 PYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKM 820 830 840 850 860 870 1590 1600 1610 1620 1630 1640 pF1KE2 QKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVM 880 890 900 910 920 930 1650 1660 1670 1680 1690 1700 pF1KE2 MSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILME 940 950 960 970 980 990 1710 1720 1730 1740 1750 1760 pF1KE2 YEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEK 1000 1010 1020 1030 1040 1050 1770 1780 1790 1800 1810 1820 pF1KE2 SSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQ 1060 1070 1080 1090 1100 1110 1830 1840 1850 1860 1870 1880 pF1KE2 LGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDV 1120 1130 1140 1150 1160 1170 1890 1900 1910 1920 1930 1940 pF1KE2 LSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDS 1180 1190 1200 1210 1220 1230 1950 1960 1970 1980 1990 2000 pF1KE2 LAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEED 1240 1250 1260 1270 1280 1290 2010 2020 2030 2040 2050 2060 pF1KE2 EDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPS 1300 1310 1320 1330 1340 1350 2070 2080 2090 2100 2110 2120 pF1KE2 AEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVG 1360 1370 1380 1390 1400 1410 2130 2140 2150 2160 2170 2180 pF1KE2 DRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLM 1420 1430 1440 1450 1460 1470 2190 2200 2210 2220 2230 2240 pF1KE2 HMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVIC 1480 1490 1500 1510 1520 1530 pF1KE2 DVLFQIGQL ::::::::: XP_016 DVLFQIGQL 2249 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 11 16:56:31 2016 done: Fri Nov 11 16:56:35 2016 Total Scan time: 26.390 Total Display time: 1.700 Function used was FASTA [36.3.4 Apr, 2011]