Result of FASTA (ccds) for pF1KE2032
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE2032, 622 aa
  1>>>pF1KE2032 622 - 622 aa - 622 aa
Library: human.CCDS.faa
  18511270 residues in 32554 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.5669+/-0.000924; mu= 18.1032+/- 0.056
 mean_var=80.4669+/-16.494, 0's: 0 Z-trim(107.0): 177  B-trim: 390 in 1/50
 Lambda= 0.142977
 statistics sampled from 9113 (9309) to 9113 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.653), E-opt: 0.2 (0.286), width:  16
 Scan time:  3.550

The best scores are:                                      opt bits E(32554)
CCDS31476.1 F2 gene_id:2147|Hs108|chr11            ( 622) 4354 908.2       0
CCDS43523.1 LPA gene_id:4018|Hs108|chr6            (2040)  524 118.5 8.7e-26
CCDS10481.1 PRSS22 gene_id:64063|Hs108|chr16       ( 317)  499 112.8   7e-25
CCDS10476.1 PRSS27 gene_id:83886|Hs108|chr16       ( 290)  478 108.5 1.3e-23
CCDS31735.1 C1S gene_id:716|Hs108|chr12            ( 688)  456 104.2 6.1e-22
CCDS10478.1 PRSS21 gene_id:10942|Hs108|chr16       ( 314)  435 99.6 6.6e-21
CCDS74857.1 TMPRSS6 gene_id:164656|Hs108|chr22     ( 824)  434 99.7 1.6e-20
CCDS33908.1 MASP1 gene_id:5648|Hs108|chr3          ( 728)  431 99.0 2.3e-20
CCDS123.1 MASP2 gene_id:10747|Hs108|chr1           ( 686)  427 98.2 3.9e-20
CCDS45469.1 PRSS8 gene_id:5652|Hs108|chr16         ( 343)  416 95.7 1.1e-19
CCDS73602.1 F7 gene_id:2155|Hs108|chr13            ( 382)  395 91.4 2.3e-18
CCDS33907.1 MASP1 gene_id:5648|Hs108|chr3          ( 699)  397 92.0 2.9e-18
CCDS32993.1 HPN gene_id:3249|Hs108|chr19           ( 417)  394 91.2 2.9e-18
CCDS58452.1 PRSS36 gene_id:146547|Hs108|chr16      ( 752)  396 91.8 3.5e-18
CCDS58453.1 PRSS36 gene_id:146547|Hs108|chr16      ( 850)  396 91.9 3.8e-18
CCDS32436.1 PRSS36 gene_id:146547|Hs108|chr16      ( 855)  396 91.9 3.9e-18
CCDS73251.1 OVCH2 gene_id:341277|Hs108|chr11       ( 565)  385 89.5 1.3e-17
CCDS10431.1 TPSAB1 gene_id:7177|Hs108|chr16        ( 275)  380 88.2 1.5e-17
CCDS8487.1 ST14 gene_id:6768|Hs108|chr11           ( 855)  378 88.1 5.1e-17
CCDS54297.1 KLK11 gene_id:11012|Hs108|chr19        ( 275)  348 81.6 1.5e-15
CCDS33757.2 MST1 gene_id:4485|Hs108|chr3           ( 725)  348 81.9 3.2e-15
CCDS10852.1 CTRL gene_id:1506|Hs108|chr16          ( 264)  340 80.0 4.5e-15
CCDS83291.1 PLAT gene_id:5327|Hs108|chr8           ( 473)  341 80.3 6.3e-15
CCDS6127.1 PLAT gene_id:5327|Hs108|chr8            ( 516)  341 80.4 6.7e-15
CCDS6126.1 PLAT gene_id:5327|Hs108|chr8            ( 562)  341 80.4 7.2e-15
CCDS60760.1 PAMR1 gene_id:25891|Hs108|chr11        ( 609)  336 79.4 1.6e-14
CCDS60759.1 PAMR1 gene_id:25891|Hs108|chr11        ( 680)  336 79.4 1.7e-14
CCDS31460.1 PAMR1 gene_id:25891|Hs108|chr11        ( 720)  336 79.4 1.8e-14
CCDS7898.1 PAMR1 gene_id:25891|Hs108|chr11         ( 737)  336 79.4 1.8e-14
CCDS5279.1 PLG gene_id:5340|Hs108|chr6             ( 810)  334 79.1 2.6e-14
CCDS47629.1 HGF gene_id:3082|Hs108|chr7            ( 210)  325 76.8 3.2e-14
CCDS46816.1 PRSS42 gene_id:339906|Hs108|chr3       ( 293)  326 77.1 3.7e-14
CCDS47627.1 HGF gene_id:3082|Hs108|chr7            ( 290)  324 76.7 4.8e-14
CCDS42110.1 PRSS33 gene_id:260429|Hs108|chr16      ( 280)  321 76.1 7.2e-14
CCDS5597.1 HGF gene_id:3082|Hs108|chr7             ( 728)  324 77.0   1e-13
CCDS2745.1 PRSS50 gene_id:29122|Hs108|chr3         ( 385)  319 75.7 1.2e-13
CCDS74856.1 TMPRSS6 gene_id:164656|Hs108|chr22     ( 802)  314 74.9 4.5e-13
CCDS13941.1 TMPRSS6 gene_id:164656|Hs108|chr22     ( 811)  314 74.9 4.6e-13
CCDS47628.1 HGF gene_id:3082|Hs108|chr7            ( 285)  308 73.4 4.7e-13
CCDS81658.1 C1R gene_id:715|Hs108|chr12            ( 705)  307 73.4 1.1e-12
CCDS47626.1 HGF gene_id:3082|Hs108|chr7            ( 723)  307 73.4 1.1e-12
CCDS3369.1 HGFAC gene_id:3083|Hs108|chr4           ( 655)  296 71.2 5.1e-12
CCDS75098.1 HGFAC gene_id:3083|Hs108|chr4          ( 662)  296 71.2 5.1e-12
CCDS81783.1 F10 gene_id:2159|Hs108|chr13           ( 332)  292 70.1 5.2e-12
CCDS9530.1 F10 gene_id:2159|Hs108|chr13            ( 488)  292 70.2 7.1e-12
CCDS82010.1 HP gene_id:3240|Hs108|chr16            ( 347)  286 68.9 1.3e-11
CCDS45525.1 HP gene_id:3240|Hs108|chr16            ( 347)  286 68.9 1.3e-11
CCDS45524.1 HP gene_id:3240|Hs108|chr16            ( 406)  286 68.9 1.4e-11
CCDS34120.1 KLKB1 gene_id:3818|Hs108|chr4          ( 638)  285 68.9 2.4e-11
CCDS5976.1 PRSS55 gene_id:203074|Hs108|chr8        ( 352)  281 67.9 2.6e-11


>>CCDS31476.1 F2 gene_id:2147|Hs108|chr11                 (622 aa)
 initn: 4354 init1: 4354 opt: 4354  Z-score: 4853.4  bits: 908.2 E(32554):    0
Smith-Waterman score: 4354; 100.0% identity (100.0% similar) in 622 aa overlap (1-622:1-622)

               10        20        30        40        50        60
pF1KE2 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS31 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS31 VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS31 NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS31 CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE2 QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS31 QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE2 DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS31 DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE2 DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS31 DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE2 DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS31 DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE2 VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS31 VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE2 RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS31 RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
              550       560       570       580       590       600

              610       620  
pF1KE2 GFYTHVFRLKKWIQKVIDQFGE
       ::::::::::::::::::::::
CCDS31 GFYTHVFRLKKWIQKVIDQFGE
              610       620  

>>CCDS43523.1 LPA gene_id:4018|Hs108|chr6                 (2040 aa)
 initn: 997 init1: 225 opt: 524  Z-score: 576.4  bits: 118.5 E(32554): 8.7e-26
Smith-Waterman score: 865; 32.0% identity (54.2% similar) in 566 aa overlap (60-617:1574-2037)

      30        40        50        60        70        80         
pF1KE2 APQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDV--FWAKY
                                     :    ::  :.  .::. :.. :  . :. 
CCDS43 AGLTENYCRNPDSGKQPWCYTTDPCVRWEYCNLTQCSETES-GVLETPTVVPVPSMEAHS
          1550      1560      1570      1580       1590      1600  

        90       100       110       120       130       140       
pF1KE2 TACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTH
        :  : .::  .   : .::     : .:::  . : .:  :: : :  ::. . .  ..
CCDS43 EAAPTEQTPVVR--QCYHGN-----GQSYRGTFSTTVTGRTCQSWSSMTPHRHQRTPENY
           1610        1620           1630      1640      1650     

       150       160       170       180       190       200       
pF1KE2 PGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLS
       :.  :  :.:::::..: ::::.: ::..: . :..  :.. . :: ..: .  .  .:.
CCDS43 PNDGLTMNYCRNPDADT-GPWCFTMDPSIRWEYCNLTRCSDTEGTV-VAPPTVIQVPSLG
        1660      1670       1680      1690      1700       1710   

       210        220       230       240       250           260  
pF1KE2 PPLEQ-CVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDF----NSAVQLVENFC
       :: :: :.   :. :.:. :.:. : ::  ::   :.   .:. :    :. . : .:.:
CCDS43 PPSEQDCMFGNGKGYRGKKATTVTGTPCQEWA---AQEPHRHSTFIPGTNKWAGLEKNYC
          1720      1730      1740         1750      1760      1770

            270       280       290       300       310       320  
pF1KE2 RNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQT
       :::::: .: :::. .    : :::.  :                        :.: .  
CCDS43 RNPDGDINGPWCYTMNPRKLFDYCDIPLC------------------------ASSSF--
             1780      1790                              1800      

            330       340       350       360       370       380  
pF1KE2 FFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLF
                   ::: .:  : :.               : :: :  :.    :::: : 
CCDS43 ------------DCG-KPQVEPKKCP-------------GSIVGGCVAHPHSWPWQVSL-
                      1810                   1820      1830        

            390       400       410       420       430       440  
pF1KE2 RKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKIS
       :    . .::..::: .:::::::::      :.   ..  : .: :...  : ....: 
CCDS43 RTRFGKHFCGGTLISPEWVLTAAHCL-----KKSSRPSSYKVILGAHQEVNLESHVQEIE
      1840      1850      1860           1870      1880      1890  

            450       460       470       480       490       500  
pF1KE2 MLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVT
       .  .....:        . ::::.::..:....: . :.:::. .    .. :  .  .:
CCDS43 V-SRLFLEPT-------QADIALLKLSRPAVITDKVMPACLPSPDY---MVTARTECYIT
            1900             1910      1920      1930         1940 

            510       520       530       540       550       560  
pF1KE2 GWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRG-
       :::. . :.    : :   .:. ..: ..:  ::.    :       ::    ..  :: 
CCDS43 GWGETQGTF----GTG---LLKEAQLLVIENEVCNHYKYI-------CA----EHLARGT
            1950             1960      1970                 1980   

             570       580       590       600       610       620 
pF1KE2 DACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG
       :.:.::::::.:     ....  .:..::: :: : .: : :..: :.  ::. ..    
CCDS43 DSCQGDSGGPLVCFE--KDKYILQGVTSWGLGCARPNKPGVYARVSRFVTWIEGMMRNN 
          1990        2000      2010      2020      2030      2040 

        
pF1KE2 E

>>CCDS10481.1 PRSS22 gene_id:64063|Hs108|chr16            (317 aa)
 initn: 393 init1: 145 opt: 499  Z-score: 560.1  bits: 112.8 E(32554): 7e-25
Smith-Waterman score: 499; 32.6% identity (62.8% similar) in 261 aa overlap (363-617:49-289)

            340       350       360       370       380       390  
pF1KE2 EADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCG
                                     :.: : :.  .  :: : . ... ..  :.
CCDS10 TSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHH--CA
       20        30        40        50        60        70        

            400       410       420        430       440       450 
pF1KE2 ASLISDRWVLTAAHCLLYPPWDKNFTENDLL-VRIGKHSRTRYERNIEKISMLEKIYIHP
       .::...:::.:::::.       :...  :. : .:  .        .:...   .  ::
CCDS10 GSLLTSRWVITAAHCF-----KDNLNKPYLFSVLLGAWQLGNPGSRSQKVGV-AWVEPHP
         80        90            100       110       120        130

             460       470       480       490       500       510 
pF1KE2 RYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETW
        :.:.:.   ::::..:.. . ::. . :.::::   :.  :  . .  ..:::....  
CCDS10 VYSWKEGACADIALVRLERSIQFSERVLPICLPD---ASIHLPPNTHCWISGWGSIQD--
              140       150       160          170       180       

             520       530            540       550       560      
pF1KE2 TANVGKGQPSVLQVVNLPIVERPVC-----KDSTRIRITDNMFCAGYKPDEGKRGDACEG
         .:   .:..:: ...::..  ::     . . .  ::..:.::::   ::.: ::: :
CCDS10 --GVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYL--EGER-DACLG
           190       200       210       220       230          240

        570       580       590       600       610       620      
pF1KE2 DSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE    
       :::::.. .   .. :   ::.:::::: . .. : :  .   ..:..:..         
CCDS10 DSGGPLMCQ--VDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLRGRA
                250       260       270       280       290        

CCDS10 QGGGALRAPSQGSGAAARS
      300       310       

>>CCDS10476.1 PRSS27 gene_id:83886|Hs108|chr16            (290 aa)
 initn: 422 init1: 116 opt: 478  Z-score: 537.3  bits: 108.5 E(32554): 1.3e-23
Smith-Waterman score: 534; 35.9% identity (62.0% similar) in 276 aa overlap (363-620:34-279)

            340       350       360       370       380       390  
pF1KE2 EADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCG
                                     :.: :.:.. :  :::: . :.. .  .::
CCDS10 PAAVPLLLLLCFGSQRAKAATACGRPRMLNRMVGGQDTQEGEWPWQVSIQRNGSH--FCG
            10        20        30        40        50          60 

            400       410       420                430       440   
pF1KE2 ASLISDRWVLTAAHCLLYPPWDKNFTENDL---------LVRIGKHSRTRYERNIEKISM
       .:::...::::::::.      .: .:..:         ::. : :.     :..:.   
CCDS10 GSLIAEQWVLTAAHCF------RNTSETSLYQVLLGARQLVQPGPHAMYARVRQVES---
              70              80        90       100       110     

           450       460       470       480       490       500   
pF1KE2 LEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTG
             .: :.   . . :.::..:. :: :..:: ::::::    . ....:..  :::
CCDS10 ------NPLYQGTAS-SADVALVELEAPVPFTNYILPVCLPD---PSVIFETGMNCWVTG
                  120        130       140          150       160  

           510       520       530            540           550    
pF1KE2 WGNLKETWTANVGKGQPSVLQVVNLPIVERPVC-----KDSTR----IRITDNMFCAGYK
       ::. .:         .: .:: . .::.. : :     ::.        : ..:.:::. 
CCDS10 WGSPSEEDLLP----EPRILQKLAVPIIDTPKCNLLYSKDTEFGYQPKTIKNDMLCAGF-
            170           180       190       200       210        

          560       570       580       590       600       610    
pF1KE2 PDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQ
        .:::. :::.::::::.:     .. : : :..:::::: :... : : .:   ..::.
CCDS10 -EEGKK-DACKGDSGGPLVCL--VGQSWLQAGVISWGEGCARQNRPGVYIRVTAHHNWIH
        220        230         240       250       260       270   

          620           
pF1KE2 KVIDQFGE         
       ..: ..           
CCDS10 RIIPKLQFQPARLGGQK
           280       290

>>CCDS31735.1 C1S gene_id:716|Hs108|chr12                 (688 aa)
 initn: 377 init1: 114 opt: 456  Z-score: 507.4  bits: 104.2 E(32554): 6.1e-22
Smith-Waterman score: 470; 28.6% identity (51.3% similar) in 472 aa overlap (184-619:249-681)

           160       170       180        190       200       210  
pF1KE2 ENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQD-QVTVAMTPRSEGSSVNLSPPLEQ
                                     : ::.     . .  .:.. .. ..  :  
CCDS31 RREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTG
      220       230       240       250       260       270        

            220        230       240       250       260           
pF1KE2 CVPDRGQQYQGR-LAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDE--
              .:.:  .    .  :  .:  :.:: .     : ..::..   :   :: :  
CCDS31 QKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYV-----FRDVVQIT---CL--DGFEVV
      280       290       300       310            320             

     270               280        290       300       310          
pF1KE2 EG--------VWCYVAGKPGDFGY-CDLNYCEEAVEEETGDGLDEDSDRAIEGRTAT-SE
       ::          :   :: ..    :.   :  .. :   .:  :: . .. : .   . 
CCDS31 EGRVGATSFYSTCQSNGKWSNSKLKCQPVDC--GIPESIENGKVEDPESTLFGSVIRYTC
      330       340       350         360       370       380      

     320       330                340       350       360       370
pF1KE2 YQTFFNPRTFGSGEADCG---------LRPLFEKKSLEDKTERELLESYIDGRIVEGSDA
        . ..  .. :.::  :.         : : . :      . :: .:     ::. ::::
CCDS31 EEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEE--KQRIIGGSDA
        390       400       410       420       430         440    

              380       390       400       410       420       430
pF1KE2 EIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHS
       .:   ::::  :  .:     :..::.. ::::::: .      ..  :  . :   . .
CCDS31 DIKNFPWQV--FFDNPW---AGGALINEYWVLTAAHVV------EGNREPTMYVGSTSVQ
          450            460       470             480       490   

              440       450               460       470       480  
pF1KE2 RTRYERNIEKISMLEKIYIHPRYNW--------RENLDRDIALMKLKKPVAFSDYIHPVC
        .:  ..  :.   :...:::  .:        : :.: ::::..:: :: ..  . :.:
CCDS31 TSRLAKS--KMLTPEHVFIHP--GWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPIC
           500         510         520       530       540         

            490       500       510         520        530         
pF1KE2 LPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQ--PSV-LQVVNLPIVERPVCKDS
       ::   .  .:.. :  : ..:::  ..   :   :.   : . :.  .   ::.:.  :.
CCDS31 LPGTSSDYNLMD-GDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTA-DA
     550       560        570       580       590       600        

     540       550       560        570       580        590       
pF1KE2 TRIRITDNMFCAGYKPDEGKRG-DACEGDSGGPFVMKSPFNN-RWYQMGIVSWGEGCDRD
           .: ::.:::     :..: :.:.::::: :....: .. ..:  :.::::  :   
CCDS31 EAYVFTPNMICAG-----GEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQC---
       610       620            630       640       650            

       600       610       620      
pF1KE2 GKYGFYTHVFRLKKWIQKVIDQFGE    
       : ::.::.:     ::.:....       
CCDS31 GTYGLYTRVKNYVDWIMKTMQENSTPRED
     660       670       680        

>>CCDS10478.1 PRSS21 gene_id:10942|Hs108|chr16            (314 aa)
 initn: 518 init1: 162 opt: 435  Z-score: 488.8  bits: 99.6 E(32554): 6.6e-21
Smith-Waterman score: 516; 37.2% identity (60.9% similar) in 274 aa overlap (360-621:38-289)

     330       340       350       360       370       380         
pF1KE2 GSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQEL
                                     : .::: : :::.:  :::  :  .  .  
CCDS10 LLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSL--RLWDSH
        10        20        30        40        50          60     

     390       400       410       420       430       440         
pF1KE2 LCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKIS---MLEK
       .::.::.: ::.::::::  .  ..     .  .:..:. .      ...      .. .
CCDS10 VCGVSLLSHRWALTAAHC--FETYSDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSN
          70        80          90       100       110       120   

        450       460       470       480       490       500      
pF1KE2 IYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGR----VT
       ::. :::    :   ::::.::. ::... .:.:.::      :: ..  ...:    ::
CCDS10 IYLSPRY--LGNSPYDIALVKLSAPVTYTKHIQPICLQ-----ASTFE--FENRTDCWVT
           130         140       150            160         170    

            510       520       530            540       550       
pF1KE2 GWGNLKETWTANVGKGQPSVLQVVNLPIVERPVC-----KDSTRIRITDNMFCAGYKPDE
       ::: .::    . .  .: .:: :.. :..  .:     : : :  :  .: ::: . . 
CCDS10 GWGYIKE----DEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDMVCAG-NAQG
          180           190       200       210       220          

       560       570       580       590       600       610       
pF1KE2 GKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVI
       ::  ::: ::::::.. ..  :. :::.:.:::: :: : .. : ::.. .  .::::..
CCDS10 GK--DACFGDSGGPLACNK--NGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLM
     230         240         250       260       270       280     

       620                          
pF1KE2 DQFGE                        
        : :                         
CCDS10 AQSGMSQPDPSWPLLFFPLLWALPLLGPV
         290       300       310    

>>CCDS74857.1 TMPRSS6 gene_id:164656|Hs108|chr22          (824 aa)
 initn: 461 init1: 146 opt: 434  Z-score: 481.7  bits: 99.7 E(32554): 1.6e-20
Smith-Waterman score: 567; 29.0% identity (56.8% similar) in 458 aa overlap (183-617:413-823)

            160       170       180       190       200            
pF1KE2 QENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPP---
                                     ::: .   .:. .:     :...:. :   
CCDS74 KYDLPCTQGQWTIQNRRLCGLRILQPYAERIPVVATAGITINFT-----SQISLTGPGVR
            390       400       410       420            430       

     210       220       230       240       250       260         
pF1KE2 LEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDE
       ..  . ....   :..  ...:: :.  :   .:   .  :  . :  .   :.. :.  
CCDS74 VHYGLYNQSDPCPGEFLCSVNGL-CVP-ACDGVKDCPNGLDERNCVCRATFQCKE-DSTC
       440       450       460         470       480       490     

     270       280       290       300       310       320         
pF1KE2 EGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTF
        ..     :.:  ..  : . :.:.:   :     ::       :. ...     ::.  
CCDS74 ISLPKVCDGQPDCLNGSDEEQCQEGVPCGTFTFQCED-------RSCVKKP----NPQC-
          500       510       520       530                  540   

     330       340       350       360          370       380      
pF1KE2 GSGEADCGLRPLFEKKSLEDKTERELLESYIDG---RIVEGSDAEIGMSPWQVMLFRKSP
        .:. ::           .: ...:  .  ..:   ::: :. .  :  :::. :  .. 
CCDS74 -DGRPDC-----------RDGSDEEHCDCGLQGPSSRIVGGAVSSEGEWPWQASLQVRGR
                        550       560       570       580       590

        390       400       410       420       430       440      
pF1KE2 QELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEK
       .  .::..::.::::.:::::.      ..   . .: .. ..::   : .. :.:   .
CCDS74 H--ICGGALIADRWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEVSF-KVS---R
                600       610       620       630       640        

        450       460       470       480       490       500      
pF1KE2 IYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGN
       . .:: :. ... : :.::..: .::. :  ..::::: :   . ... : .  .:::: 
CCDS74 LLLHP-YHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPAR---SHFFEPGLHCWITGWGA
           650       660       670       680          690       700

        510                      520         530       540         
pF1KE2 LKET------------WTANVGKGQ---P--SVLQVVNLPIVERPVCKDSTRIRITDNMF
       :.:             :  : :.     :  ..:: :.. .. . .:..  : ..:  :.
CCDS74 LREGALRADAVALFYGWR-NQGSETCCCPISNALQKVDVQLIPQDLCSEVYRYQVTPRML
              710        720       730       740       750         

     550       560       570       580       590       600         
pF1KE2 CAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRL
       ::::.  .::. :::.::::::.: :. ...::.  :.:::: :: : . .: ::..  .
CCDS74 CAGYR--KGKK-DACQGDSGGPLVCKA-LSGRWFLAGLVSWGLGCGRPNYFGVYTRITGV
     760          770       780        790       800       810     

     610       620  
pF1KE2 KKWIQKVIDQFGE
        .:::.:.     
CCDS74 ISWIQQVVT    
         820        

>>CCDS33908.1 MASP1 gene_id:5648|Hs108|chr3               (728 aa)
 initn: 412 init1: 127 opt: 431  Z-score: 479.2  bits: 99.0 E(32554): 2.3e-20
Smith-Waterman score: 486; 35.1% identity (59.8% similar) in 271 aa overlap (363-613:449-711)

            340       350       360       370       380            
pF1KE2 EADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLF----RKSPQE
                                     ::. : .:: :. :::...      . :..
CCDS33 VWMNKVLGRSLPTCLPECGQPSRSLPSLVKRIIGGRNAEPGLFPWQALIVVEDTSRVPND
      420       430       440       450       460       470        

      390        400       410          420       430       440    
pF1KE2 LLCGA-SLISDRWVLTAAHCLLYPPWDKNF---TENDLLVRIGKHSRTRYERNIEKISML
          :. .:.:  :.::::: :     : .    ... . : .: :. .: ...    :  
CCDS33 KWFGSGALLSASWILTAAHVLRSQRRDTTVIPVSKEHVTVYLGLHD-VR-DKSGAVNSSA
      480       490       500       510       520         530      

          450       460       470       480       490       500    
pF1KE2 EKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGW
        .. .:: .:  .: ..::::..:..:: .. .. :::::  :  .      . : :.::
CCDS33 ARVVLHPDFNI-QNYNHDIALVQLQEPVPLGPHVMPVCLPRLEPEGP--APHMLGLVAGW
        540        550       560       570       580         590   

          510         520          530       540            550    
pF1KE2 GNLKETWTAN--VGKGQPS---VLQVVNLPIVERPVCKDSTRIR-----ITDNMFCAGYK
       :  . . :..  ...:  .   ::: :.::.: .  :: : . :     .:.::::::: 
CCDS33 GISNPNVTVDEIISSGTRTLSDVLQYVKLPVVPHAECKTSYESRSGNYSVTENMFCAGYY
           600       610       620       630       640       650   

          560       570       580       590         600       610  
pF1KE2 PDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWG--EGCDRDGKYGFYTHVFRLKKW
         :: . :.: ::::: ::. . ...::  .:.::::  : :     :: ::.:     :
CCDS33 --EGGK-DTCLGDSGGAFVIFDDLSQRWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDW
              660       670       680       690       700       710

            620          
pF1KE2 IQKVIDQFGE        
       .                 
CCDS33 VWEQMGLPQSVVEPQVER
              720        

>>CCDS123.1 MASP2 gene_id:10747|Hs108|chr1                (686 aa)
 initn: 451 init1: 125 opt: 427  Z-score: 475.1  bits: 98.2 E(32554): 3.9e-20
Smith-Waterman score: 478; 25.7% identity (53.6% similar) in 541 aa overlap (118-620:186-686)

        90       100       110       120       130        140      
pF1KE2 TACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHK-PEINSTT
                                     :.:   :::   .:   .::.  :...: :
CCDS12 CHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSG---ELSSPEYPRPYPKLSSCT
         160       170       180       190          200       210  

        150                160       170       180       190       
pF1KE2 HPGA---------DLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTP
       .  .         :. :.:  .    :  :. .    : :...   : ::.   :.    
CCDS12 YSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEHG--PFCGK---TLPHRI
            220       230       240       250         260          

       200       210       220        230          240       250   
pF1KE2 RSEGSSVNLSPPLEQCVPDRGQQYQG-RLAVTTHGLPC---LAWASAQAKALSKHQDFNS
       ......:...      : :.. .. : ..  :. . ::   .:  ..... .. .  ...
CCDS12 ETKSNTVTIT-----FVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKYILKD
       270            280       290       300       310       320  

           260       270            280           290       300    
pF1KE2 AVQLVENFCRNPDGDEEG-----VWCYVAGKPGDFGY----CDLNYCEEAVEEETGDGLD
       . ..   ::..     .:      .  :  : :..      :..  :    .  .:  ..
CCDS12 SFSI---FCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDDLPSGR-VE
               330       340       350       360       370         

          310       320          330       340       350           
pF1KE2 EDSDRAIEGRTATSEY---QTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERE-----LL
         .  ..    :. .:   .::.. .. ..:.  :    .. ... : .         : 
CCDS12 YITGPGVTTYKAVIQYSCEETFYTMKV-NDGKYVCEADGFWTSSKGEKSLPVCEPVCGLS
      380       390       400        410       420       430       

        360       370       380       390       400       410      
pF1KE2 ESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKN
            :::  :. :. :  ::::...  .      :: :. : ::::::: .    ....
CCDS12 ARTTGGRIYGGQKAKPGDFPWQVLILGGTTAA---GA-LLYDNWVLTAAHAV----YEQK
       440       450       460          470        480             

        420       430       440       450       460       470      
pF1KE2 FTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSD
          . : .:.:  .:   . .    .  : ..::  :.   ..: ::::.::.. :....
CCDS12 HDASALDIRMGTLKRLSPHYTQ---AWSEAVFIHEGYTHDAGFDNDIALIKLNNKVVINS
     490       500       510          520       530       540      

        480       490       500       510       520       530      
pF1KE2 YIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVC
        : :.::: :. : :....   : ..:::  .. . :         :. :..:::..  :
CCDS12 NITPICLP-RKEAESFMRTDDIGTASGWGLTQRGFLARN-------LMYVDIPIVDHQKC
        550        560       570       580              590        

              540       550       560       570       580       590
pF1KE2 KDS------TRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSW
         .       :  .: ::.::: .   ::  :.:.::::: .:. .  ..::.  :::::
CCDS12 TAAYEKPPYPRGSVTANMLCAGLESG-GK--DSCRGDSGGALVFLDSETERWFVGGIVSW
      600       610       620          630       640       650     

               600       610       620  
pF1KE2 GE-GCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
       :  .: . :.:: ::.:.    ::...:..:  
CCDS12 GSMNCGEAGQYGVYTKVINYIPWIENIISDF  
         660       670       680        

>>CCDS45469.1 PRSS8 gene_id:5652|Hs108|chr16              (343 aa)
 initn: 509 init1: 117 opt: 416  Z-score: 467.1  bits: 95.7 E(32554): 1.1e-19
Smith-Waterman score: 542; 36.1% identity (62.8% similar) in 266 aa overlap (363-620:44-288)

            340       350       360       370       380       390  
pF1KE2 EADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCG
                                     ::. ::.:  :. :::: .  .. .  .::
CCDS45 AVAILLYLGLLRSGTGAEGAEAPCGVAPQARITGGSSAVAGQWPWQVSITYEGVH--VCG
            20        30        40        50        60          70 

            400       410       420       430       440       450  
pF1KE2 ASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPR
       .::.:..:::.::::  .:   ..  ..   :..: :.   : ..  :.: :. :  :: 
CCDS45 GSLVSEQWVLSAAHC--FP---SEHHKEAYEVKLGAHQLDSYSEDA-KVSTLKDIIPHPS
              80             90       100       110        120     

            460       470       480       490       500       510  
pF1KE2 YNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWT
       :  .:. . ::::..:..:..:: ::.:.:::   .: . .  : .  :::::..  .  
CCDS45 Y-LQEGSQGDIALLQLSRPITFSRYIRPICLP---AANASFPNGLHCTVTGWGHVAPS--
          130       140       150          160       170           

            520       530       540               550       560    
pF1KE2 ANVGKGQPSVLQVVNLPIVERPVCKDSTRIR--------ITDNMFCAGYKPDEGKRGDAC
         :.   :. :: ...:.. : .:.    :         . ..: ::::   :: . :::
CCDS45 --VSLLTPKPLQQLEVPLISRETCNCLYNIDAKPEEPHFVQEDMVCAGYV--EGGK-DAC
       180       190       200       210       220         230     

          570       580       590       600       610       620    
pF1KE2 EGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE  
       .::::::  .. : .. ::  ::::::..:   .. : :: .    .:::. . ..    
CCDS45 QGDSGGP--LSCPVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKVTELQPRV
          240         250       260       270       280       290  

CCDS45 VPQTQESQPDSNLCGSHLAFSSAPAQGLLRPILFLPLGLALGLLSPWLSEH
            300       310       320       330       340   




622 residues in 1 query   sequences
18511270 residues in 32554 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sun Nov  6 09:42:19 2016 done: Sun Nov  6 09:42:20 2016
 Total Scan time:  3.550 Total Display time:  0.100

Function used was FASTA [36.3.4 Apr, 2011]
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