Result of FASTA (ccds) for
pF1KE2499
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2499, 4574 aa
1>>>pF1KE2499 4574 - 4574 aa - 4574 aa
Library: human.CCDS.faa
18921897 residues in 33420 sequences
Statistics: Expectation_n fit: rho(ln(x))= 15.9901+/-0.00196; mu= -21.0357+/- 0.114
mean_var=731.9020+/-157.718, 0's: 0 Z-trim(107.6): 323 B-trim: 78 in 1/50
Lambda= 0.047408
statistics sampled from 9538 (9803) to 9538 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.582), E-opt: 0.2 (0.293), width: 16
Scan time: 6.660
The best scores are: opt bits E(33420)
CCDS43769.1 PLEC gene_id:5339|Hs109|chr8 (4574) 29005 2002.9 0
CCDS43772.1 PLEC gene_id:5339|Hs109|chr8 (4684) 28594 1974.8 0
CCDS43771.1 PLEC gene_id:5339|Hs109|chr8 (4525) 28593 1974.7 0
CCDS43774.1 PLEC gene_id:5339|Hs109|chr8 (4551) 28590 1974.5 0
CCDS47936.1 PLEC gene_id:5339|Hs109|chr8 (4515) 28589 1974.5 0
CCDS43770.1 PLEC gene_id:5339|Hs109|chr8 (4533) 28587 1974.3 0
CCDS43775.1 PLEC gene_id:5339|Hs109|chr8 (4547) 28587 1974.3 0
CCDS43773.1 PLEC gene_id:5339|Hs109|chr8 (4547) 28586 1974.3 0
CCDS4959.1 DST gene_id:667|Hs109|chr6 (2649) 3281 243.4 2.2e-62
CCDS435.1 MACF1 gene_id:23499|Hs109|chr1 (5430) 2794 210.3 4.1e-52
CCDS47443.1 DST gene_id:667|Hs109|chr6 (5171) 2684 202.8 7.3e-50
CCDS75474.1 DST gene_id:667|Hs109|chr6 (5537) 2684 202.8 7.7e-50
CCDS47368.1 DSP gene_id:1832|Hs109|chr6 (2272) 2334 178.5 6.3e-43
CCDS4501.1 DSP gene_id:1832|Hs109|chr6 (2871) 2334 178.6 7.5e-43
CCDS75800.1 EPPK1 gene_id:83481|Hs109|chr8 (5088) 2233 171.9 1.4e-40
CCDS8150.1 SPTBN2 gene_id:6712|Hs109|chr11 (2390) 1226 102.8 4.2e-20
CCDS33198.1 SPTBN1 gene_id:6711|Hs109|chr2 (2364) 1149 97.5 1.6e-18
CCDS32100.1 SPTB gene_id:6710|Hs109|chr14 (2137) 1141 96.9 2.2e-18
CCDS32099.1 SPTB gene_id:6710|Hs109|chr14 (2328) 1141 96.9 2.3e-18
CCDS33199.1 SPTBN1 gene_id:6711|Hs109|chr2 (2155) 1133 96.4 3.2e-18
CCDS12559.1 SPTBN4 gene_id:57731|Hs109|chr19 (2564) 1025 89.0 6.1e-16
CCDS61599.1 SPTBN5 gene_id:51332|Hs109|chr15 (3674) 1017 88.6 1.2e-15
CCDS10526.1 PPL gene_id:5493|Hs109|chr16 (1756) 926 82.1 5e-14
CCDS55395.1 DMD gene_id:1756|Hs109|chrX (3681) 909 81.2 2e-13
CCDS14233.1 DMD gene_id:1756|Hs109|chrX (3685) 900 80.6 3e-13
CCDS11737.1 EVPL gene_id:2125|Hs109|chr17 (2033) 881 79.1 4.7e-13
CCDS82207.1 EVPL gene_id:2125|Hs109|chr17 (2055) 881 79.1 4.8e-13
>>CCDS43769.1 PLEC gene_id:5339|Hs109|chr8 (4574 aa)
initn: 29005 init1: 29005 opt: 29005 Z-score: 10738.8 bits: 2002.9 E(33420): 0
Smith-Waterman score: 29005; 100.0% identity (100.0% similar) in 4574 aa overlap (1-4574:1-4574)
10 20 30 40 50 60
pF1KE2 MSGEDAEVRAVSEDVSNGSSGSPSPGDTLPWNLGKTQRSRRSGGGAGSNGSVLDPAERAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 MSGEDAEVRAVSEDVSNGSSGSPSPGDTLPWNLGKTQRSRRSGGGAGSNGSVLDPAERAV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 IRIADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 IRIADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 RMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 ADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLEC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 EKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVC
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 DYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLE
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 AQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHY
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 QAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIR
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLAL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 QAMPLADSQAVREQLQQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL
:::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE2 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE2 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE2 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE2 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE2 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KE2 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KE2 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KE2 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KE2 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KE2 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT
2410 2420 2430 2440 2450 2460
2470 2480 2490 2500 2510 2520
pF1KE2 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ
2470 2480 2490 2500 2510 2520
2530 2540 2550 2560 2570 2580
pF1KE2 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME
2530 2540 2550 2560 2570 2580
2590 2600 2610 2620 2630 2640
pF1KE2 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE
2590 2600 2610 2620 2630 2640
2650 2660 2670 2680 2690 2700
pF1KE2 EVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA
2650 2660 2670 2680 2690 2700
2710 2720 2730 2740 2750 2760
pF1KE2 QGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ
2710 2720 2730 2740 2750 2760
2770 2780 2790 2800 2810 2820
pF1KE2 AASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQ
2770 2780 2790 2800 2810 2820
2830 2840 2850 2860 2870 2880
pF1KE2 KGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGF
2830 2840 2850 2860 2870 2880
2890 2900 2910 2920 2930 2940
pF1KE2 FDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 FDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAP
2890 2900 2910 2920 2930 2940
2950 2960 2970 2980 2990 3000
pF1KE2 FGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 FGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLC
2950 2960 2970 2980 2990 3000
3010 3020 3030 3040 3050 3060
pF1KE2 FEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 FEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEE
3010 3020 3030 3040 3050 3060
3070 3080 3090 3100 3110 3120
pF1KE2 AGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHE
3070 3080 3090 3100 3110 3120
3130 3140 3150 3160 3170 3180
pF1KE2 KLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVP
3130 3140 3150 3160 3170 3180
3190 3200 3210 3220 3230 3240
pF1KE2 LDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLS
3190 3200 3210 3220 3230 3240
3250 3260 3270 3280 3290 3300
pF1KE2 EKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQ
3250 3260 3270 3280 3290 3300
3310 3320 3330 3340 3350 3360
pF1KE2 FRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 FRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKD
3310 3320 3330 3340 3350 3360
3370 3380 3390 3400 3410 3420
pF1KE2 GKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQA
3370 3380 3390 3400 3410 3420
3430 3440 3450 3460 3470 3480
pF1KE2 ATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQK
3430 3440 3450 3460 3470 3480
3490 3500 3510 3520 3530 3540
pF1KE2 GLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFF
3490 3500 3510 3520 3530 3540
3550 3560 3570 3580 3590 3600
pF1KE2 DPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQID
3550 3560 3570 3580 3590 3600
3610 3620 3630 3640 3650 3660
pF1KE2 IPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 IPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIR
3610 3620 3630 3640 3650 3660
3670 3680 3690 3700 3710 3720
pF1KE2 QQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVA
3670 3680 3690 3700 3710 3720
3730 3740 3750 3760 3770 3780
pF1KE2 GVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLV
3730 3740 3750 3760 3770 3780
3790 3800 3810 3820 3830 3840
pF1KE2 GPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPR
3790 3800 3810 3820 3830 3840
3850 3860 3870 3880 3890 3900
pF1KE2 LGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQL
3850 3860 3870 3880 3890 3900
3910 3920 3930 3940 3950 3960
pF1KE2 LLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTS
3910 3920 3930 3940 3950 3960
3970 3980 3990 4000 4010 4020
pF1KE2 CIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 CIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRM
3970 3980 3990 4000 4010 4020
4030 4040 4050 4060 4070 4080
pF1KE2 GIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGII
4030 4040 4050 4060 4070 4080
4090 4100 4110 4120 4130 4140
pF1KE2 DPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQ
4090 4100 4110 4120 4130 4140
4150 4160 4170 4180 4190 4200
pF1KE2 TGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSE
4150 4160 4170 4180 4190 4200
4210 4220 4230 4240 4250 4260
pF1KE2 QECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFA
4210 4220 4230 4240 4250 4260
4270 4280 4290 4300 4310 4320
pF1KE2 DMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVS
4270 4280 4290 4300 4310 4320
4330 4340 4350 4360 4370 4380
pF1KE2 ITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQ
4330 4340 4350 4360 4370 4380
4390 4400 4410 4420 4430 4440
pF1KE2 KAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQ
4390 4400 4410 4420 4430 4440
4450 4460 4470 4480 4490 4500
pF1KE2 RGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKG
4450 4460 4470 4480 4490 4500
4510 4520 4530 4540 4550 4560
pF1KE2 YYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYAS
4510 4520 4530 4540 4550 4560
4570
pF1KE2 GSSASLGGPESAVA
::::::::::::::
CCDS43 GSSASLGGPESAVA
4570
>>CCDS43772.1 PLEC gene_id:5339|Hs109|chr8 (4684 aa)
initn: 28586 init1: 28586 opt: 28594 Z-score: 10586.7 bits: 1974.8 E(33420): 0
Smith-Waterman score: 28594; 99.0% identity (99.3% similar) in 4564 aa overlap (18-4574:121-4684)
10 20 30 40
pF1KE2 MSGEDAEVRAVSEDVSNGSSGSPSPGDTLPWNLGKTQRSRRSGGGAG
: ::: :: . .. : .. .
CCDS43 EIVPASLQRVRRPVAMVMPARRTPHVQAVQGPLGSPPKRGPLPTEEQRVYRRKELEEVSP
100 110 120 130 140 150
50 60 70 80 90 100
pF1KE2 SNGSVLDPAERAVIR-------IADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDG
. : ..:.. : .::::::::::::::::::::::::::::::::::::
CCDS43 ETPVVPATTQRTLARPGPEPAPATDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDG
160 170 180 190 200 210
110 120 130 140 150 160
pF1KE2 HNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 HNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLT
220 230 240 250 260 270
170 180 190 200 210 220
pF1KE2 LGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLF
280 290 300 310 320 330
230 240 250 260 270 280
pF1KE2 NAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 NAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIIT
340 350 360 370 380 390
290 300 310 320 330 340
pF1KE2 YVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEE
400 410 420 430 440 450
350 360 370 380 390 400
pF1KE2 IEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 IEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKL
460 470 480 490 500 510
410 420 430 440 450 460
pF1KE2 HVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 HVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQ
520 530 540 550 560 570
470 480 490 500 510 520
pF1KE2 RAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLK
580 590 600 610 620 630
530 540 550 560 570 580
pF1KE2 AGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEA
640 650 660 670 680 690
590 600 610 620 630 640
pF1KE2 QLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLR
700 710 720 730 740 750
650 660 670 680 690 700
pF1KE2 SLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIK
760 770 780 790 800 810
710 720 730 740 750 760
pF1KE2 ELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVRE
820 830 840 850 860 870
770 780 790 800 810 820
pF1KE2 AEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ
880 890 900 910 920 930
830 840 850 860 870 880
pF1KE2 LKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPS
940 950 960 970 980 990
890 900 910 920 930 940
pF1KE2 VCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLAT
1000 1010 1020 1030 1040 1050
950 960 970 980 990 1000
pF1KE2 FRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 FRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLE
1060 1070 1080 1090 1100 1110
1010 1020 1030 1040 1050 1060
pF1KE2 QGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEV
1120 1130 1140 1150 1160 1170
1070 1080 1090 1100 1110 1120
pF1KE2 EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISL
1180 1190 1200 1210 1220 1230
1130 1140 1150 1160 1170 1180
pF1KE2 VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDEL
1240 1250 1260 1270 1280 1290
1190 1200 1210 1220 1230 1240
pF1KE2 RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR
1300 1310 1320 1330 1340 1350
1250 1260 1270 1280 1290 1300
pF1KE2 ESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLQQEQALLEEIERHGEKVEECQRFAK
:::::::::::::::::::::::::::::::::::.::::::::::::::::::::::::
CCDS43 ESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK
1360 1370 1380 1390 1400 1410
1310 1320 1330 1340 1350 1360
pF1KE2 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY
1420 1430 1440 1450 1460 1470
1370 1380 1390 1400 1410 1420
pF1KE2 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL
1480 1490 1500 1510 1520 1530
1430 1440 1450 1460 1470 1480
pF1KE2 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE
1540 1550 1560 1570 1580 1590
1490 1500 1510 1520 1530 1540
pF1KE2 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA
1600 1610 1620 1630 1640 1650
1550 1560 1570 1580 1590 1600
pF1KE2 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS
1660 1670 1680 1690 1700 1710
1610 1620 1630 1640 1650 1660
pF1KE2 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER
1720 1730 1740 1750 1760 1770
1670 1680 1690 1700 1710 1720
pF1KE2 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE
1780 1790 1800 1810 1820 1830
1730 1740 1750 1760 1770 1780
pF1KE2 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL
1840 1850 1860 1870 1880 1890
1790 1800 1810 1820 1830 1840
pF1KE2 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA
1900 1910 1920 1930 1940 1950
1850 1860 1870 1880 1890 1900
pF1KE2 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE
1960 1970 1980 1990 2000 2010
1910 1920 1930 1940 1950 1960
pF1KE2 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS
2020 2030 2040 2050 2060 2070
1970 1980 1990 2000 2010 2020
pF1KE2 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS
2080 2090 2100 2110 2120 2130
2030 2040 2050 2060 2070 2080
pF1KE2 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA
2140 2150 2160 2170 2180 2190
2090 2100 2110 2120 2130 2140
pF1KE2 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE
2200 2210 2220 2230 2240 2250
2150 2160 2170 2180 2190 2200
pF1KE2 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF
2260 2270 2280 2290 2300 2310
2210 2220 2230 2240 2250 2260
pF1KE2 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV
2320 2330 2340 2350 2360 2370
2270 2280 2290 2300 2310 2320
pF1KE2 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL
2380 2390 2400 2410 2420 2430
2330 2340 2350 2360 2370 2380
pF1KE2 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM
2440 2450 2460 2470 2480 2490
2390 2400 2410 2420 2430 2440
pF1KE2 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI
2500 2510 2520 2530 2540 2550
2450 2460 2470 2480 2490 2500
pF1KE2 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS
2560 2570 2580 2590 2600 2610
2510 2520 2530 2540 2550 2560
pF1KE2 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE
2620 2630 2640 2650 2660 2670
2570 2580 2590 2600 2610 2620
pF1KE2 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR
2680 2690 2700 2710 2720 2730
2630 2640 2650 2660 2670 2680
pF1KE2 LREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV
2740 2750 2760 2770 2780 2790
2690 2700 2710 2720 2730 2740
pF1KE2 SAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVY
2800 2810 2820 2830 2840 2850
2750 2760 2770 2780 2790 2800
pF1KE2 AALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERA
2860 2870 2880 2890 2900 2910
2810 2820 2830 2840 2850 2860
pF1KE2 VTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRG
2920 2930 2940 2950 2960 2970
2870 2880 2890 2900 2910 2920
pF1KE2 YFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGE
2980 2990 3000 3010 3020 3030
2930 2940 2950 2960 2970 2980
pF1KE2 LVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVE
3040 3050 3060 3070 3080 3090
2990 3000 3010 3020 3030 3040
pF1KE2 KIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEV
3100 3110 3120 3130 3140 3150
3050 3060 3070 3080 3090 3100
pF1KE2 DTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATS
3160 3170 3180 3190 3200 3210
3110 3120 3130 3140 3150 3160
pF1KE2 ARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRL
3220 3230 3240 3250 3260 3270
3170 3180 3190 3200 3210 3220
pF1KE2 LDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYG
3280 3290 3300 3310 3320 3330
3230 3240 3250 3260 3270 3280
pF1KE2 ELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTV
3340 3350 3360 3370 3380 3390
3290 3300 3310 3320 3330 3340
pF1KE2 WELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 WELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVP
3400 3410 3420 3430 3440 3450
3350 3360 3370 3380 3390 3400
pF1KE2 ASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYE
3460 3470 3480 3490 3500 3510
3410 3420 3430 3440 3450 3460
pF1KE2 AMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAV
3520 3530 3540 3550 3560 3570
3470 3480 3490 3500 3510 3520
pF1KE2 TGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGY
3580 3590 3600 3610 3620 3630
3530 3540 3550 3560 3570 3580
pF1KE2 FSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 FSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVE
3640 3650 3660 3670 3680 3690
3590 3600 3610 3620 3630 3640
pF1KE2 TTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRV
3700 3710 3720 3730 3740 3750
3650 3660 3670 3680 3690 3700
pF1KE2 TKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSL
3760 3770 3780 3790 3800 3810
3710 3720 3730 3740 3750 3760
pF1KE2 REALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 REALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFL
3820 3830 3840 3850 3860 3870
3770 3780 3790 3800 3810 3820
pF1KE2 LDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPT
3880 3890 3900 3910 3920 3930
3830 3840 3850 3860 3870 3880
pF1KE2 EEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDE
3940 3950 3960 3970 3980 3990
3890 3900 3910 3920 3930 3940
pF1KE2 RLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLRE
4000 4010 4020 4030 4040 4050
3950 3960 3970 3980 3990 4000
pF1KE2 GLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAAT
4060 4070 4080 4090 4100 4110
4010 4020 4030 4040 4050 4060
pF1KE2 GYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGL
4120 4130 4140 4150 4160 4170
4070 4080 4090 4100 4110 4120
pF1KE2 ILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDP
4180 4190 4200 4210 4220 4230
4130 4140 4150 4160 4170 4180
pF1KE2 NTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 NTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMS
4240 4250 4260 4270 4280 4290
4190 4200 4210 4220 4230 4240
pF1KE2 VYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNL
4300 4310 4320 4330 4340 4350
4250 4260 4270 4280 4290 4300
pF1KE2 IDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 IDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDP
4360 4370 4380 4390 4400 4410
4310 4320 4330 4340 4350 4360
pF1KE2 TEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVT
4420 4430 4440 4450 4460 4470
4370 4380 4390 4400 4410 4420
pF1KE2 DAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYL
4480 4490 4500 4510 4520 4530
4430 4440 4450 4460 4470 4480
pF1KE2 TGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRS
4540 4550 4560 4570 4580 4590
4490 4500 4510 4520 4530 4540
pF1KE2 MVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 MVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGF
4600 4610 4620 4630 4640 4650
4550 4560 4570
pF1KE2 SMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
::::::::::::::::::::::::::::::::::
CCDS43 SMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
4660 4670 4680
>>CCDS43771.1 PLEC gene_id:5339|Hs109|chr8 (4525 aa)
initn: 28587 init1: 28587 opt: 28593 Z-score: 10586.6 bits: 1974.7 E(33420): 0
Smith-Waterman score: 28593; 99.7% identity (99.8% similar) in 4525 aa overlap (53-4574:1-4525)
30 40 50 60 70
pF1KE2 PSPGDTLPWNLGKTQRSRRSGGGAGSNGSVLDPA---ERAVIRIADERDRVQKKTFTKWV
.::. . . . :::::::::::::::
CCDS43 MDPSRAIQNEISSLKDERDRVQKKTFTKWV
10 20 30
80 90 100 110 120 130
pF1KE2 NKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 NKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRH
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE2 RQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMV
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE2 EGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGV
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE2 TRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLL
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE2 QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQA
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE2 GQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQL
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE2 NQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 NQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYR
400 410 420 430 440 450
500 510 520 530 540 550
pF1KE2 RVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWV
460 470 480 490 500 510
560 570 580 590 600 610
pF1KE2 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRD
520 530 540 550 560 570
620 630 640 650 660 670
pF1KE2 CLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 CLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMT
580 590 600 610 620 630
680 690 700 710 720 730
pF1KE2 AKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCC
640 650 660 670 680 690
740 750 760 770 780 790
pF1KE2 CIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 CIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKE
700 710 720 730 740 750
800 810 820 830 840 850
pF1KE2 QLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVG
760 770 780 790 800 810
860 870 880 890 900 910
pF1KE2 PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKS
820 830 840 850 860 870
920 930 940 950 960 970
pF1KE2 LLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRL
880 890 900 910 920 930
980 990 1000 1010 1020 1030
pF1KE2 MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLD
940 950 960 970 980 990
1040 1050 1060 1070 1080 1090
pF1KE2 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG
1000 1010 1020 1030 1040 1050
1100 1110 1120 1130 1140 1150
pF1KE2 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL
1060 1070 1080 1090 1100 1110
1160 1170 1180 1190 1200 1210
pF1KE2 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL
1120 1130 1140 1150 1160 1170
1220 1230 1240 1250 1260 1270
pF1KE2 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLQQEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::
CCDS43 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ
1180 1190 1200 1210 1220 1230
1280 1290 1300 1310 1320 1330
pF1KE2 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV
1240 1250 1260 1270 1280 1290
1340 1350 1360 1370 1380 1390
pF1KE2 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ
1300 1310 1320 1330 1340 1350
1400 1410 1420 1430 1440 1450
pF1KE2 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE
1360 1370 1380 1390 1400 1410
1460 1470 1480 1490 1500 1510
pF1KE2 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA
1420 1430 1440 1450 1460 1470
1520 1530 1540 1550 1560 1570
pF1KE2 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL
1480 1490 1500 1510 1520 1530
1580 1590 1600 1610 1620 1630
pF1KE2 RQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAER
1540 1550 1560 1570 1580 1590
1640 1650 1660 1670 1680 1690
pF1KE2 RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE
1600 1610 1620 1630 1640 1650
1700 1710 1720 1730 1740 1750
pF1KE2 ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL
1660 1670 1680 1690 1700 1710
1760 1770 1780 1790 1800 1810
pF1KE2 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE
1720 1730 1740 1750 1760 1770
1820 1830 1840 1850 1860 1870
pF1KE2 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA
1780 1790 1800 1810 1820 1830
1880 1890 1900 1910 1920 1930
pF1KE2 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL
1840 1850 1860 1870 1880 1890
1940 1950 1960 1970 1980 1990
pF1KE2 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ
1900 1910 1920 1930 1940 1950
2000 2010 2020 2030 2040 2050
pF1KE2 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES
1960 1970 1980 1990 2000 2010
2060 2070 2080 2090 2100 2110
pF1KE2 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE
2020 2030 2040 2050 2060 2070
2120 2130 2140 2150 2160 2170
pF1KE2 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA
2080 2090 2100 2110 2120 2130
2180 2190 2200 2210 2220 2230
pF1KE2 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL
2140 2150 2160 2170 2180 2190
2240 2250 2260 2270 2280 2290
pF1KE2 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK
2200 2210 2220 2230 2240 2250
2300 2310 2320 2330 2340 2350
pF1KE2 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL
2260 2270 2280 2290 2300 2310
2360 2370 2380 2390 2400 2410
pF1KE2 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM
2320 2330 2340 2350 2360 2370
2420 2430 2440 2450 2460 2470
pF1KE2 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI
2380 2390 2400 2410 2420 2430
2480 2490 2500 2510 2520 2530
pF1KE2 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE
2440 2450 2460 2470 2480 2490
2540 2550 2560 2570 2580 2590
pF1KE2 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE
2500 2510 2520 2530 2540 2550
2600 2610 2620 2630 2640 2650
pF1KE2 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA
2560 2570 2580 2590 2600 2610
2660 2670 2680 2690 2700 2710
pF1KE2 LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYL
2620 2630 2640 2650 2660 2670
2720 2730 2740 2750 2760 2770
pF1KE2 QGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNE
2680 2690 2700 2710 2720 2730
2780 2790 2800 2810 2820 2830
pF1KE2 AVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIAT
2740 2750 2760 2770 2780 2790
2840 2850 2860 2870 2880 2890
pF1KE2 GGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCV
2800 2810 2820 2830 2840 2850
2900 2910 2920 2930 2940 2950
pF1KE2 EDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEY
2860 2870 2880 2890 2900 2910
2960 2970 2980 2990 3000 3010
pF1KE2 FTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 FTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVI
2920 2930 2940 2950 2960 2970
3020 3030 3040 3050 3060 3070
pF1KE2 DRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSD
2980 2990 3000 3010 3020 3030
3080 3090 3100 3110 3120 3130
pF1KE2 MAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 MAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQ
3040 3050 3060 3070 3080 3090
3140 3150 3160 3170 3180 3190
pF1KE2 SVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALS
3100 3110 3120 3130 3140 3150
3200 3210 3220 3230 3240 3250
pF1KE2 APRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 APRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARE
3160 3170 3180 3190 3200 3210
3260 3270 3280 3290 3300 3310
pF1KE2 TFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIV
3220 3230 3240 3250 3260 3270
3320 3330 3340 3350 3360 3370
pF1KE2 EEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQ
3280 3290 3300 3310 3320 3330
3380 3390 3400 3410 3420 3430
pF1KE2 GSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEA
3340 3350 3360 3370 3380 3390
3440 3450 3460 3470 3480 3490
pF1KE2 VKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATG
3400 3410 3420 3430 3440 3450
3500 3510 3520 3530 3540 3550
pF1KE2 GIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVE
3460 3470 3480 3490 3500 3510
3560 3570 3580 3590 3600 3610
pF1KE2 DPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQ
3520 3530 3540 3550 3560 3570
3620 3630 3640 3650 3660 3670
pF1KE2 SDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDL
3580 3590 3600 3610 3620 3630
3680 3690 3700 3710 3720 3730
pF1KE2 FEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 FEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKK
3640 3650 3660 3670 3680 3690
3740 3750 3760 3770 3780 3790
pF1KE2 GLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYR
3700 3710 3720 3730 3740 3750
3800 3810 3820 3830 3840 3850
pF1KE2 DPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKD
3760 3770 3780 3790 3800 3810
3860 3870 3880 3890 3900 3910
pF1KE2 THDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 THDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQI
3820 3830 3840 3850 3860 3870
3920 3930 3940 3950 3960 3970
pF1KE2 TMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQA
3880 3890 3900 3910 3920 3930
3980 3990 4000 4010 4020 4030
pF1KE2 MKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 MKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVT
3940 3950 3960 3970 3980 3990
4040 4050 4060 4070 4080 4090
pF1KE2 GYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLF
4000 4010 4020 4030 4040 4050
4100 4110 4120 4130 4140 4150
pF1KE2 DEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSS
4060 4070 4080 4090 4100 4110
4160 4170 4180 4190 4200 4210
pF1KE2 KSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKS
4120 4130 4140 4150 4160 4170
4220 4230 4240 4250 4260 4270
pF1KE2 MIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 MIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGS
4180 4190 4200 4210 4220 4230
4280 4290 4300 4310 4320 4330
pF1KE2 SSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLL
4240 4250 4260 4270 4280 4290
4340 4350 4360 4370 4380 4390
pF1KE2 EAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQ
4300 4310 4320 4330 4340 4350
4400 4410 4420 4430 4440 4450
pF1KE2 ALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYS
4360 4370 4380 4390 4400 4410
4460 4470 4480 4490 4500 4510
pF1KE2 KYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTG
4420 4430 4440 4450 4460 4470
4520 4530 4540 4550 4560 4570
pF1KE2 SRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
4480 4490 4500 4510 4520
>>CCDS43774.1 PLEC gene_id:5339|Hs109|chr8 (4551 aa)
initn: 28586 init1: 28586 opt: 28590 Z-score: 10585.4 bits: 1974.5 E(33420): 0
Smith-Waterman score: 28590; 99.7% identity (99.8% similar) in 4525 aa overlap (54-4574:27-4551)
30 40 50 60 70
pF1KE2 SPGDTLPWNLGKTQRSRRSGGGAGSNGSVLDPAERAVIR----IADERDRVQKKTFTKWV
.::.:. . .:::::::::::::::
CCDS43 MSGAGGAFASPREVLLERPCWLDGGCEPARRGYLYQQLCCVDERDRVQKKTFTKWV
10 20 30 40 50
80 90 100 110 120 130
pF1KE2 NKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 NKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRH
60 70 80 90 100 110
140 150 160 170 180 190
pF1KE2 RQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMV
120 130 140 150 160 170
200 210 220 230 240 250
pF1KE2 EGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGV
180 190 200 210 220 230
260 270 280 290 300 310
pF1KE2 TRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLL
240 250 260 270 280 290
320 330 340 350 360 370
pF1KE2 QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQA
300 310 320 330 340 350
380 390 400 410 420 430
pF1KE2 GQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQL
360 370 380 390 400 410
440 450 460 470 480 490
pF1KE2 NQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 NQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYR
420 430 440 450 460 470
500 510 520 530 540 550
pF1KE2 RVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWV
480 490 500 510 520 530
560 570 580 590 600 610
pF1KE2 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRD
540 550 560 570 580 590
620 630 640 650 660 670
pF1KE2 CLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 CLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMT
600 610 620 630 640 650
680 690 700 710 720 730
pF1KE2 AKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCC
660 670 680 690 700 710
740 750 760 770 780 790
pF1KE2 CIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 CIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKE
720 730 740 750 760 770
800 810 820 830 840 850
pF1KE2 QLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVG
780 790 800 810 820 830
860 870 880 890 900 910
pF1KE2 PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKS
840 850 860 870 880 890
920 930 940 950 960 970
pF1KE2 LLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRL
900 910 920 930 940 950
980 990 1000 1010 1020 1030
pF1KE2 MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLD
960 970 980 990 1000 1010
1040 1050 1060 1070 1080 1090
pF1KE2 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG
1020 1030 1040 1050 1060 1070
1100 1110 1120 1130 1140 1150
pF1KE2 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL
1080 1090 1100 1110 1120 1130
1160 1170 1180 1190 1200 1210
pF1KE2 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL
1140 1150 1160 1170 1180 1190
1220 1230 1240 1250 1260 1270
pF1KE2 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLQQEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::
CCDS43 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ
1200 1210 1220 1230 1240 1250
1280 1290 1300 1310 1320 1330
pF1KE2 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV
1260 1270 1280 1290 1300 1310
1340 1350 1360 1370 1380 1390
pF1KE2 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ
1320 1330 1340 1350 1360 1370
1400 1410 1420 1430 1440 1450
pF1KE2 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE
1380 1390 1400 1410 1420 1430
1460 1470 1480 1490 1500 1510
pF1KE2 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA
1440 1450 1460 1470 1480 1490
1520 1530 1540 1550 1560 1570
pF1KE2 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL
1500 1510 1520 1530 1540 1550
1580 1590 1600 1610 1620 1630
pF1KE2 RQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAER
1560 1570 1580 1590 1600 1610
1640 1650 1660 1670 1680 1690
pF1KE2 RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE
1620 1630 1640 1650 1660 1670
1700 1710 1720 1730 1740 1750
pF1KE2 ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL
1680 1690 1700 1710 1720 1730
1760 1770 1780 1790 1800 1810
pF1KE2 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE
1740 1750 1760 1770 1780 1790
1820 1830 1840 1850 1860 1870
pF1KE2 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA
1800 1810 1820 1830 1840 1850
1880 1890 1900 1910 1920 1930
pF1KE2 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL
1860 1870 1880 1890 1900 1910
1940 1950 1960 1970 1980 1990
pF1KE2 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ
1920 1930 1940 1950 1960 1970
2000 2010 2020 2030 2040 2050
pF1KE2 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES
1980 1990 2000 2010 2020 2030
2060 2070 2080 2090 2100 2110
pF1KE2 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE
2040 2050 2060 2070 2080 2090
2120 2130 2140 2150 2160 2170
pF1KE2 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA
2100 2110 2120 2130 2140 2150
2180 2190 2200 2210 2220 2230
pF1KE2 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL
2160 2170 2180 2190 2200 2210
2240 2250 2260 2270 2280 2290
pF1KE2 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK
2220 2230 2240 2250 2260 2270
2300 2310 2320 2330 2340 2350
pF1KE2 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL
2280 2290 2300 2310 2320 2330
2360 2370 2380 2390 2400 2410
pF1KE2 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM
2340 2350 2360 2370 2380 2390
2420 2430 2440 2450 2460 2470
pF1KE2 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI
2400 2410 2420 2430 2440 2450
2480 2490 2500 2510 2520 2530
pF1KE2 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE
2460 2470 2480 2490 2500 2510
2540 2550 2560 2570 2580 2590
pF1KE2 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE
2520 2530 2540 2550 2560 2570
2600 2610 2620 2630 2640 2650
pF1KE2 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA
2580 2590 2600 2610 2620 2630
2660 2670 2680 2690 2700 2710
pF1KE2 LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYL
2640 2650 2660 2670 2680 2690
2720 2730 2740 2750 2760 2770
pF1KE2 QGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNE
2700 2710 2720 2730 2740 2750
2780 2790 2800 2810 2820 2830
pF1KE2 AVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIAT
2760 2770 2780 2790 2800 2810
2840 2850 2860 2870 2880 2890
pF1KE2 GGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCV
2820 2830 2840 2850 2860 2870
2900 2910 2920 2930 2940 2950
pF1KE2 EDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEY
2880 2890 2900 2910 2920 2930
2960 2970 2980 2990 3000 3010
pF1KE2 FTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 FTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVI
2940 2950 2960 2970 2980 2990
3020 3030 3040 3050 3060 3070
pF1KE2 DRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSD
3000 3010 3020 3030 3040 3050
3080 3090 3100 3110 3120 3130
pF1KE2 MAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 MAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQ
3060 3070 3080 3090 3100 3110
3140 3150 3160 3170 3180 3190
pF1KE2 SVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALS
3120 3130 3140 3150 3160 3170
3200 3210 3220 3230 3240 3250
pF1KE2 APRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 APRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARE
3180 3190 3200 3210 3220 3230
3260 3270 3280 3290 3300 3310
pF1KE2 TFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIV
3240 3250 3260 3270 3280 3290
3320 3330 3340 3350 3360 3370
pF1KE2 EEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQ
3300 3310 3320 3330 3340 3350
3380 3390 3400 3410 3420 3430
pF1KE2 GSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEA
3360 3370 3380 3390 3400 3410
3440 3450 3460 3470 3480 3490
pF1KE2 VKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATG
3420 3430 3440 3450 3460 3470
3500 3510 3520 3530 3540 3550
pF1KE2 GIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVE
3480 3490 3500 3510 3520 3530
3560 3570 3580 3590 3600 3610
pF1KE2 DPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQ
3540 3550 3560 3570 3580 3590
3620 3630 3640 3650 3660 3670
pF1KE2 SDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDL
3600 3610 3620 3630 3640 3650
3680 3690 3700 3710 3720 3730
pF1KE2 FEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 FEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKK
3660 3670 3680 3690 3700 3710
3740 3750 3760 3770 3780 3790
pF1KE2 GLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYR
3720 3730 3740 3750 3760 3770
3800 3810 3820 3830 3840 3850
pF1KE2 DPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKD
3780 3790 3800 3810 3820 3830
3860 3870 3880 3890 3900 3910
pF1KE2 THDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 THDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQI
3840 3850 3860 3870 3880 3890
3920 3930 3940 3950 3960 3970
pF1KE2 TMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQA
3900 3910 3920 3930 3940 3950
3980 3990 4000 4010 4020 4030
pF1KE2 MKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 MKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVT
3960 3970 3980 3990 4000 4010
4040 4050 4060 4070 4080 4090
pF1KE2 GYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLF
4020 4030 4040 4050 4060 4070
4100 4110 4120 4130 4140 4150
pF1KE2 DEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSS
4080 4090 4100 4110 4120 4130
4160 4170 4180 4190 4200 4210
pF1KE2 KSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKS
4140 4150 4160 4170 4180 4190
4220 4230 4240 4250 4260 4270
pF1KE2 MIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 MIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGS
4200 4210 4220 4230 4240 4250
4280 4290 4300 4310 4320 4330
pF1KE2 SSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLL
4260 4270 4280 4290 4300 4310
4340 4350 4360 4370 4380 4390
pF1KE2 EAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQ
4320 4330 4340 4350 4360 4370
4400 4410 4420 4430 4440 4450
pF1KE2 ALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYS
4380 4390 4400 4410 4420 4430
4460 4470 4480 4490 4500 4510
pF1KE2 KYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTG
4440 4450 4460 4470 4480 4490
4520 4530 4540 4550 4560 4570
pF1KE2 SRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
4500 4510 4520 4530 4540 4550
>>CCDS47936.1 PLEC gene_id:5339|Hs109|chr8 (4515 aa)
initn: 28589 init1: 28589 opt: 28589 Z-score: 10585.1 bits: 1974.5 E(33420): 0
Smith-Waterman score: 28589; 99.9% identity (100.0% similar) in 4512 aa overlap (63-4574:4-4515)
40 50 60 70 80 90
pF1KE2 LGKTQRSRRSGGGAGSNGSVLDPAERAVIRIADERDRVQKKTFTKWVNKHLIKAQRHISD
. ::::::::::::::::::::::::::::
CCDS47 MKIVPDERDRVQKKTFTKWVNKHLIKAQRHISD
10 20 30
100 110 120 130 140 150
pF1KE2 LYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 LYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDI
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE2 ADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 ADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTS
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE2 SWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 SWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQ
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE2 PDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 PDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEER
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE2 RFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 RFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLD
280 290 300 310 320 330
400 410 420 430 440 450
pF1KE2 VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRL
340 350 360 370 380 390
460 470 480 490 500 510
pF1KE2 LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR
400 410 420 430 440 450
520 530 540 550 560 570
pF1KE2 TEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 TEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWG
460 470 480 490 500 510
580 590 600 610 620 630
pF1KE2 VDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 VDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLL
520 530 540 550 560 570
640 650 660 670 680 690
pF1KE2 NSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMREL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 NSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMREL
580 590 600 610 620 630
700 710 720 730 740 750
pF1KE2 ELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 ELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYF
640 650 660 670 680 690
760 770 780 790 800 810
pF1KE2 QFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 QFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA
700 710 720 730 740 750
820 830 840 850 860 870
pF1KE2 KRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 KRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSS
760 770 780 790 800 810
880 890 900 910 920 930
pF1KE2 GSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 GSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL
820 830 840 850 860 870
940 950 960 970 980 990
pF1KE2 IRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 IRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHY
880 890 900 910 920 930
1000 1010 1020 1030 1040 1050
pF1KE2 QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE
940 950 960 970 980 990
1060 1070 1080 1090 1100 1110
pF1KE2 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYL
1000 1010 1020 1030 1040 1050
1120 1130 1140 1150 1160 1170
pF1KE2 EKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 EKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT
1060 1070 1080 1090 1100 1110
1180 1190 1200 1210 1220 1230
pF1KE2 FDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 FDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQL
1120 1130 1140 1150 1160 1170
1240 1250 1260 1270 1280 1290
pF1KE2 GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLQQEQALLEEIERHGEKV
:::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::
CCDS47 GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKV
1180 1190 1200 1210 1220 1230
1300 1310 1320 1330 1340 1350
pF1KE2 EECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 EECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE
1240 1250 1260 1270 1280 1290
1360 1370 1380 1390 1400 1410
pF1KE2 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ
1300 1310 1320 1330 1340 1350
1420 1430 1440 1450 1460 1470
pF1KE2 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER
1360 1370 1380 1390 1400 1410
1480 1490 1500 1510 1520 1530
pF1KE2 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD
1420 1430 1440 1450 1460 1470
1540 1550 1560 1570 1580 1590
pF1KE2 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV
1480 1490 1500 1510 1520 1530
1600 1610 1620 1630 1640 1650
pF1KE2 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE
1540 1550 1560 1570 1580 1590
1660 1670 1680 1690 1700 1710
pF1KE2 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR
1600 1610 1620 1630 1640 1650
1720 1730 1740 1750 1760 1770
pF1KE2 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA
1660 1670 1680 1690 1700 1710
1780 1790 1800 1810 1820 1830
pF1KE2 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR
1720 1730 1740 1750 1760 1770
1840 1850 1860 1870 1880 1890
pF1KE2 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER
1780 1790 1800 1810 1820 1830
1900 1910 1920 1930 1940 1950
pF1KE2 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE
1840 1850 1860 1870 1880 1890
1960 1970 1980 1990 2000 2010
pF1KE2 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE
1900 1910 1920 1930 1940 1950
2020 2030 2040 2050 2060 2070
pF1KE2 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK
1960 1970 1980 1990 2000 2010
2080 2090 2100 2110 2120 2130
pF1KE2 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA
2020 2030 2040 2050 2060 2070
2140 2150 2160 2170 2180 2190
pF1KE2 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA
2080 2090 2100 2110 2120 2130
2200 2210 2220 2230 2240 2250
pF1KE2 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ
2140 2150 2160 2170 2180 2190
2260 2270 2280 2290 2300 2310
pF1KE2 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV
2200 2210 2220 2230 2240 2250
2320 2330 2340 2350 2360 2370
pF1KE2 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR
2260 2270 2280 2290 2300 2310
2380 2390 2400 2410 2420 2430
pF1KE2 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR
2320 2330 2340 2350 2360 2370
2440 2450 2460 2470 2480 2490
pF1KE2 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE
2380 2390 2400 2410 2420 2430
2500 2510 2520 2530 2540 2550
pF1KE2 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA
2440 2450 2460 2470 2480 2490
2560 2570 2580 2590 2600 2610
pF1KE2 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE
2500 2510 2520 2530 2540 2550
2620 2630 2640 2650 2660 2670
pF1KE2 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS
2560 2570 2580 2590 2600 2610
2680 2690 2700 2710 2720 2730
pF1KE2 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKA
2620 2630 2640 2650 2660 2670
2740 2750 2760 2770 2780 2790
pF1KE2 TNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 TNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHH
2680 2690 2700 2710 2720 2730
2800 2810 2820 2830 2840 2850
pF1KE2 KLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 KLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVP
2740 2750 2760 2770 2780 2790
2860 2870 2880 2890 2900 2910
pF1KE2 VDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 VDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLT
2800 2810 2820 2830 2840 2850
2920 2930 2940 2950 2960 2970
pF1KE2 DKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 DKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQF
2860 2870 2880 2890 2900 2910
2980 2990 3000 3010 3020 3030
pF1KE2 RTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 RTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGER
2920 2930 2940 2950 2960 2970
3040 3050 3060 3070 3080 3090
pF1KE2 SVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 SVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTG
2980 2990 3000 3010 3020 3030
3100 3110 3120 3130 3140 3150
pF1KE2 HIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 HIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLI
3040 3050 3060 3070 3080 3090
3160 3170 3180 3190 3200 3210
pF1KE2 PREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 PREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPS
3100 3110 3120 3130 3140 3150
3220 3230 3240 3250 3260 3270
pF1KE2 TGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 TGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGG
3160 3170 3180 3190 3200 3210
3280 3290 3300 3310 3320 3330
pF1KE2 FKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 FKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSF
3220 3230 3240 3250 3260 3270
3340 3350 3360 3370 3380 3390
pF1KE2 SGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 SGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDT
3280 3290 3300 3310 3320 3330
3400 3410 3420 3430 3440 3450
pF1KE2 KEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 KEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQ
3340 3350 3360 3370 3380 3390
3460 3470 3480 3490 3500 3510
pF1KE2 LLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 LLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPV
3400 3410 3420 3430 3440 3450
3520 3530 3540 3550 3560 3570
pF1KE2 DVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 DVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKG
3460 3470 3480 3490 3500 3510
3580 3590 3600 3610 3620 3630
pF1KE2 AEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 AEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM
3520 3530 3540 3550 3560 3570
3640 3650 3660 3670 3680 3690
pF1KE2 ADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 ADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNL
3580 3590 3600 3610 3620 3630
3700 3710 3720 3730 3740 3750
pF1KE2 LREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 LREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLE
3640 3650 3660 3670 3680 3690
3760 3770 3780 3790 3800 3810
pF1KE2 AQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 AQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQA
3700 3710 3720 3730 3740 3750
3820 3830 3840 3850 3860 3870
pF1KE2 MKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 MKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRS
3760 3770 3780 3790 3800 3810
3880 3890 3900 3910 3920 3930
pF1KE2 YVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 YVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDE
3820 3830 3840 3850 3860 3870
3940 3950 3960 3970 3980 3990
pF1KE2 ATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 ATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFE
3880 3890 3900 3910 3920 3930
4000 4010 4020 4030 4040 4050
pF1KE2 LLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 LLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISL
3940 3950 3960 3970 3980 3990
4060 4070 4080 4090 4100 4110
pF1KE2 FQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 FQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSD
4000 4010 4020 4030 4040 4050
4120 4130 4140 4150 4160 4170
pF1KE2 DTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 DTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVD
4060 4070 4080 4090 4100 4110
4180 4190 4200 4210 4220 4230
pF1KE2 PETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 PETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDI
4120 4130 4140 4150 4160 4170
4240 4250 4260 4270 4280 4290
pF1KE2 DDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 DDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRT
4180 4190 4200 4210 4220 4230
4300 4310 4320 4330 4340 4350
pF1KE2 QLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 QLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPS
4240 4250 4260 4270 4280 4290
4360 4370 4380 4390 4400 4410
pF1KE2 TGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 TGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQ
4300 4310 4320 4330 4340 4350
4420 4430 4440 4450 4460 4470
pF1KE2 RFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 RFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKIS
4360 4370 4380 4390 4400 4410
4480 4490 4500 4510 4520 4530
pF1KE2 YKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 YKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGS
4420 4430 4440 4450 4460 4470
4540 4550 4560 4570
pF1KE2 FDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
::::::::::::::::::::::::::::::::::::::::::
CCDS47 FDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
4480 4490 4500 4510
>>CCDS43770.1 PLEC gene_id:5339|Hs109|chr8 (4533 aa)
initn: 28587 init1: 28587 opt: 28587 Z-score: 10584.3 bits: 1974.3 E(33420): 0
Smith-Waterman score: 28587; 99.9% identity (100.0% similar) in 4513 aa overlap (62-4574:21-4533)
40 50 60 70 80 90
pF1KE2 NLGKTQRSRRSGGGAGSNGSVLDPAERAVIRIADERDRVQKKTFTKWVNKHLIKAQRHIS
. :::::::::::::::::::::::::::
CCDS43 MAGPLPDEQDFIQAYEEVREKYKDERDRVQKKTFTKWVNKHLIKAQRHIS
10 20 30 40 50
100 110 120 130 140 150
pF1KE2 DLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDD
60 70 80 90 100 110
160 170 180 190 200 210
pF1KE2 IADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 IADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFT
120 130 140 150 160 170
220 230 240 250 260 270
pF1KE2 SSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVP
180 190 200 210 220 230
280 290 300 310 320 330
pF1KE2 QPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEE
240 250 260 270 280 290
340 350 360 370 380 390
pF1KE2 RRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPL
300 310 320 330 340 350
400 410 420 430 440 450
pF1KE2 DVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVR
360 370 380 390 400 410
460 470 480 490 500 510
pF1KE2 LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI
420 430 440 450 460 470
520 530 540 550 560 570
pF1KE2 RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW
480 490 500 510 520 530
580 590 600 610 620 630
pF1KE2 GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKL
540 550 560 570 580 590
640 650 660 670 680 690
pF1KE2 LNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRE
600 610 620 630 640 650
700 710 720 730 740 750
pF1KE2 LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY
660 670 680 690 700 710
760 770 780 790 800 810
pF1KE2 FQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 FQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGL
720 730 740 750 760 770
820 830 840 850 860 870
pF1KE2 AKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSS
780 790 800 810 820 830
880 890 900 910 920 930
pF1KE2 SGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQ
840 850 860 870 880 890
940 950 960 970 980 990
pF1KE2 LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHH
900 910 920 930 940 950
1000 1010 1020 1030 1040 1050
pF1KE2 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA
960 970 980 990 1000 1010
1060 1070 1080 1090 1100 1110
pF1KE2 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIY
1020 1030 1040 1050 1060 1070
1120 1130 1140 1150 1160 1170
pF1KE2 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP
1080 1090 1100 1110 1120 1130
1180 1190 1200 1210 1220 1230
pF1KE2 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ
1140 1150 1160 1170 1180 1190
1240 1250 1260 1270 1280 1290
pF1KE2 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLQQEQALLEEIERHGEK
::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::
CCDS43 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK
1200 1210 1220 1230 1240 1250
1300 1310 1320 1330 1340 1350
pF1KE2 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS
1260 1270 1280 1290 1300 1310
1360 1370 1380 1390 1400 1410
pF1KE2 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA
1320 1330 1340 1350 1360 1370
1420 1430 1440 1450 1460 1470
pF1KE2 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE
1380 1390 1400 1410 1420 1430
1480 1490 1500 1510 1520 1530
pF1KE2 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ
1440 1450 1460 1470 1480 1490
1540 1550 1560 1570 1580 1590
pF1KE2 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ
1500 1510 1520 1530 1540 1550
1600 1610 1620 1630 1640 1650
pF1KE2 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR
1560 1570 1580 1590 1600 1610
1660 1670 1680 1690 1700 1710
pF1KE2 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV
1620 1630 1640 1650 1660 1670
1720 1730 1740 1750 1760 1770
pF1KE2 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA
1680 1690 1700 1710 1720 1730
1780 1790 1800 1810 1820 1830
pF1KE2 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA
1740 1750 1760 1770 1780 1790
1840 1850 1860 1870 1880 1890
pF1KE2 RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE
1800 1810 1820 1830 1840 1850
1900 1910 1920 1930 1940 1950
pF1KE2 RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE
1860 1870 1880 1890 1900 1910
1960 1970 1980 1990 2000 2010
pF1KE2 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR
1920 1930 1940 1950 1960 1970
2020 2030 2040 2050 2060 2070
pF1KE2 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ
1980 1990 2000 2010 2020 2030
2080 2090 2100 2110 2120 2130
pF1KE2 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA
2040 2050 2060 2070 2080 2090
2140 2150 2160 2170 2180 2190
pF1KE2 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD
2100 2110 2120 2130 2140 2150
2200 2210 2220 2230 2240 2250
pF1KE2 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS
2160 2170 2180 2190 2200 2210
2260 2270 2280 2290 2300 2310
pF1KE2 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS
2220 2230 2240 2250 2260 2270
2320 2330 2340 2350 2360 2370
pF1KE2 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR
2280 2290 2300 2310 2320 2330
2380 2390 2400 2410 2420 2430
pF1KE2 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ
2340 2350 2360 2370 2380 2390
2440 2450 2460 2470 2480 2490
pF1KE2 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ
2400 2410 2420 2430 2440 2450
2500 2510 2520 2530 2540 2550
pF1KE2 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV
2460 2470 2480 2490 2500 2510
2560 2570 2580 2590 2600 2610
pF1KE2 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE
2520 2530 2540 2550 2560 2570
2620 2630 2640 2650 2660 2670
pF1KE2 ELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEH
2580 2590 2600 2610 2620 2630
2680 2690 2700 2710 2720 2730
pF1KE2 SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK
2640 2650 2660 2670 2680 2690
2740 2750 2760 2770 2780 2790
pF1KE2 ATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELH
2700 2710 2720 2730 2740 2750
2800 2810 2820 2830 2840 2850
pF1KE2 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV
2760 2770 2780 2790 2800 2810
2860 2870 2880 2890 2900 2910
pF1KE2 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL
2820 2830 2840 2850 2860 2870
2920 2930 2940 2950 2960 2970
pF1KE2 TDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQ
2880 2890 2900 2910 2920 2930
2980 2990 3000 3010 3020 3030
pF1KE2 FRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 FRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGE
2940 2950 2960 2970 2980 2990
3040 3050 3060 3070 3080 3090
pF1KE2 RSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGT
3000 3010 3020 3030 3040 3050
3100 3110 3120 3130 3140 3150
pF1KE2 GHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGL
3060 3070 3080 3090 3100 3110
3160 3170 3180 3190 3200 3210
pF1KE2 IPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 IPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDP
3120 3130 3140 3150 3160 3170
3220 3230 3240 3250 3260 3270
pF1KE2 STGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 STGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVG
3180 3190 3200 3210 3220 3230
3280 3290 3300 3310 3320 3330
pF1KE2 GFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLS
3240 3250 3260 3270 3280 3290
3340 3350 3360 3370 3380 3390
pF1KE2 FSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 FSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLED
3300 3310 3320 3330 3340 3350
3400 3410 3420 3430 3440 3450
pF1KE2 TKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHE
3360 3370 3380 3390 3400 3410
3460 3470 3480 3490 3500 3510
pF1KE2 QLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVP
3420 3430 3440 3450 3460 3470
3520 3530 3540 3550 3560 3570
pF1KE2 VDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLK
3480 3490 3500 3510 3520 3530
3580 3590 3600 3610 3620 3630
pF1KE2 GAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQL
3540 3550 3560 3570 3580 3590
3640 3650 3660 3670 3680 3690
pF1KE2 MADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 MADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYN
3600 3610 3620 3630 3640 3650
3700 3710 3720 3730 3740 3750
pF1KE2 LLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLL
3660 3670 3680 3690 3700 3710
3760 3770 3780 3790 3800 3810
pF1KE2 EAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQ
3720 3730 3740 3750 3760 3770
3820 3830 3840 3850 3860 3870
pF1KE2 AMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVR
3780 3790 3800 3810 3820 3830
3880 3890 3900 3910 3920 3930
pF1KE2 SYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMD
3840 3850 3860 3870 3880 3890
3940 3950 3960 3970 3980 3990
pF1KE2 EATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAF
3900 3910 3920 3930 3940 3950
4000 4010 4020 4030 4040 4050
pF1KE2 ELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLIS
3960 3970 3980 3990 4000 4010
4060 4070 4080 4090 4100 4110
pF1KE2 LFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPS
4020 4030 4040 4050 4060 4070
4120 4130 4140 4150 4160 4170
pF1KE2 DDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIV
4080 4090 4100 4110 4120 4130
4180 4190 4200 4210 4220 4230
pF1KE2 DPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYD
4140 4150 4160 4170 4180 4190
4240 4250 4260 4270 4280 4290
pF1KE2 IDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 IDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSR
4200 4210 4220 4230 4240 4250
4300 4310 4320 4330 4340 4350
pF1KE2 TQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDP
4260 4270 4280 4290 4300 4310
4360 4370 4380 4390 4400 4410
pF1KE2 STGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 STGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAG
4320 4330 4340 4350 4360 4370
4420 4430 4440 4450 4460 4470
pF1KE2 QRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKI
4380 4390 4400 4410 4420 4430
4480 4490 4500 4510 4520 4530
pF1KE2 SYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRG
4440 4450 4460 4470 4480 4490
4540 4550 4560 4570
pF1KE2 SFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
:::::::::::::::::::::::::::::::::::::::::::
CCDS43 SFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
4500 4510 4520 4530
>>CCDS43775.1 PLEC gene_id:5339|Hs109|chr8 (4547 aa)
initn: 28586 init1: 28586 opt: 28587 Z-score: 10584.3 bits: 1974.3 E(33420): 0
Smith-Waterman score: 28587; 99.8% identity (99.9% similar) in 4520 aa overlap (59-4574:28-4547)
30 40 50 60 70 80
pF1KE2 LPWNLGKTQRSRRSGGGAGSNGSVLDPAERAVIRIA----DERDRVQKKTFTKWVNKHLI
::.: . ::::::::::::::::::::
CCDS43 MSQHQLRVPQPEGLGRKRTSSEDNLYLAVLRASEGKKDERDRVQKKTFTKWVNKHLI
10 20 30 40 50
90 100 110 120 130 140
pF1KE2 KAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKL
60 70 80 90 100 110
150 160 170 180 190 200
pF1KE2 VNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQG
120 130 140 150 160 170
210 220 230 240 250 260
pF1KE2 LRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLD
180 190 200 210 220 230
270 280 290 300 310 320
pF1KE2 PEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 PEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRH
240 250 260 270 280 290
330 340 350 360 370 380
pF1KE2 HTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 HTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV
300 310 320 330 340 350
390 400 410 420 430 440
pF1KE2 PPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 PPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADA
360 370 380 390 400 410
450 460 470 480 490 500
pF1KE2 LLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRL
420 430 440 450 460 470
510 520 530 540 550 560
pF1KE2 HERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 HERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQH
480 490 500 510 520 530
570 580 590 600 610 620
pF1KE2 RVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRL
540 550 560 570 580 590
630 640 650 660 670 680
pF1KE2 DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES
600 610 620 630 640 650
690 700 710 720 730 740
pF1KE2 YSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAH
660 670 680 690 700 710
750 760 770 780 790 800
pF1KE2 LKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEY
720 730 740 750 760 770
810 820 830 840 850 860
pF1KE2 KGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPS
780 790 800 810 820 830
870 880 890 900 910 920
pF1KE2 HWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 HWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQ
840 850 860 870 880 890
930 940 950 960 970 980
pF1KE2 SLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAERE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAERE
900 910 920 930 940 950
990 1000 1010 1020 1030 1040
pF1KE2 YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPAR
960 970 980 990 1000 1010
1050 1060 1070 1080 1090 1100
pF1KE2 ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQV
1020 1030 1040 1050 1060 1070
1110 1120 1130 1140 1150 1160
pF1KE2 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRA
1080 1090 1100 1110 1120 1130
1170 1180 1190 1200 1210 1220
pF1KE2 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV
1140 1150 1160 1170 1180 1190
1230 1240 1250 1260 1270 1280
pF1KE2 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLQQEQALLEE
:::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::
CCDS43 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE
1200 1210 1220 1230 1240 1250
1290 1300 1310 1320 1330 1340
pF1KE2 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV
1260 1270 1280 1290 1300 1310
1350 1360 1370 1380 1390 1400
pF1KE2 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE
1320 1330 1340 1350 1360 1370
1410 1420 1430 1440 1450 1460
pF1KE2 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA
1380 1390 1400 1410 1420 1430
1470 1480 1490 1500 1510 1520
pF1KE2 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE
1440 1450 1460 1470 1480 1490
1530 1540 1550 1560 1570 1580
pF1KE2 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV
1500 1510 1520 1530 1540 1550
1590 1600 1610 1620 1630 1640
pF1KE2 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ
1560 1570 1580 1590 1600 1610
1650 1660 1670 1680 1690 1700
pF1KE2 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG
1620 1630 1640 1650 1660 1670
1710 1720 1730 1740 1750 1760
pF1KE2 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA
1680 1690 1700 1710 1720 1730
1770 1780 1790 1800 1810 1820
pF1KE2 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR
1740 1750 1760 1770 1780 1790
1830 1840 1850 1860 1870 1880
pF1KE2 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK
1800 1810 1820 1830 1840 1850
1890 1900 1910 1920 1930 1940
pF1KE2 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL
1860 1870 1880 1890 1900 1910
1950 1960 1970 1980 1990 2000
pF1KE2 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA
1920 1930 1940 1950 1960 1970
2010 2020 2030 2040 2050 2060
pF1KE2 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ
1980 1990 2000 2010 2020 2030
2070 2080 2090 2100 2110 2120
pF1KE2 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR
2040 2050 2060 2070 2080 2090
2130 2140 2150 2160 2170 2180
pF1KE2 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL
2100 2110 2120 2130 2140 2150
2190 2200 2210 2220 2230 2240
pF1KE2 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT
2160 2170 2180 2190 2200 2210
2250 2260 2270 2280 2290 2300
pF1KE2 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA
2220 2230 2240 2250 2260 2270
2310 2320 2330 2340 2350 2360
pF1KE2 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE
2280 2290 2300 2310 2320 2330
2370 2380 2390 2400 2410 2420
pF1KE2 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA
2340 2350 2360 2370 2380 2390
2430 2440 2450 2460 2470 2480
pF1KE2 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER
2400 2410 2420 2430 2440 2450
2490 2500 2510 2520 2530 2540
pF1KE2 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE
2460 2470 2480 2490 2500 2510
2550 2560 2570 2580 2590 2600
pF1KE2 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE
2520 2530 2540 2550 2560 2570
2610 2620 2630 2640 2650 2660
pF1KE2 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA
2580 2590 2600 2610 2620 2630
2670 2680 2690 2700 2710 2720
pF1KE2 AEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSS
2640 2650 2660 2670 2680 2690
2730 2740 2750 2760 2770 2780
pF1KE2 IAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 IAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEG
2700 2710 2720 2730 2740 2750
2790 2800 2810 2820 2830 2840
pF1KE2 VVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVID
2760 2770 2780 2790 2800 2810
2850 2860 2870 2880 2890 2900
pF1KE2 PVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 PVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPET
2820 2830 2840 2850 2860 2870
2910 2920 2930 2940 2950 2960
pF1KE2 GLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQ
2880 2890 2900 2910 2920 2930
2970 2980 2990 3000 3010 3020
pF1KE2 RRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELY
2940 2950 2960 2970 2980 2990
3030 3040 3050 3060 3070 3080
pF1KE2 QQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVAL
3000 3010 3020 3030 3040 3050
3090 3100 3110 3120 3130 3140
pF1KE2 LEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLF
3060 3070 3080 3090 3100 3110
3150 3160 3170 3180 3190 3200
pF1KE2 QALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRAD
3120 3130 3140 3150 3160 3170
3210 3220 3230 3240 3250 3260
pF1KE2 AKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKT
3180 3190 3200 3210 3220 3230
3270 3280 3290 3300 3310 3320
pF1KE2 PVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 PVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVET
3240 3250 3260 3270 3280 3290
3330 3340 3350 3360 3370 3380
pF1KE2 LRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCL
3300 3310 3320 3330 3340 3350
3390 3400 3410 3420 3430 3440
pF1KE2 AGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGV
3360 3370 3380 3390 3400 3410
3450 3460 3470 3480 3490 3500
pF1KE2 VGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDP
3420 3430 3440 3450 3460 3470
3510 3520 3530 3540 3550 3560
pF1KE2 VHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETG
3480 3490 3500 3510 3520 3530
3570 3580 3590 3600 3610 3620
pF1KE2 LRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIP
3540 3550 3560 3570 3580 3590
3630 3640 3650 3660 3670 3680
pF1KE2 EEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARI
3600 3610 3620 3630 3640 3650
3690 3700 3710 3720 3730 3740
pF1KE2 ISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSA
3660 3670 3680 3690 3700 3710
3750 3760 3770 3780 3790 3800
pF1KE2 EVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTE
3720 3730 3740 3750 3760 3770
3810 3820 3830 3840 3850 3860
pF1KE2 QTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQL
3780 3790 3800 3810 3820 3830
3870 3880 3890 3900 3910 3920
pF1KE2 SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEEL
3840 3850 3860 3870 3880 3890
3930 3940 3950 3960 3970 3980
pF1KE2 VRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGI
3900 3910 3920 3930 3940 3950
3990 4000 4010 4020 4030 4040
pF1KE2 IRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 IRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDP
3960 3970 3980 3990 4000 4010
4050 4060 4070 4080 4090 4100
pF1KE2 YSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMN
4020 4030 4040 4050 4060 4070
4110 4120 4130 4140 4150 4160
pF1KE2 EILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVR
4080 4090 4100 4110 4120 4130
4170 4180 4190 4200 4210 4220
pF1KE2 KRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDR
4140 4150 4160 4170 4180 4190
4230 4240 4250 4260 4270 4280
pF1KE2 RSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYP
4200 4210 4220 4230 4240 4250
4290 4300 4310 4320 4330 4340
pF1KE2 ISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQAC
4260 4270 4280 4290 4300 4310
4350 4360 4370 4380 4390 4400
pF1KE2 TGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKG
4320 4330 4340 4350 4360 4370
4410 4420 4430 4440 4450 4460
pF1KE2 WLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 WLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTC
4380 4390 4400 4410 4420 4430
4470 4480 4490 4500 4510 4520
pF1KE2 PKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 PKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGS
4440 4450 4460 4470 4480 4490
4530 4540 4550 4560 4570
pF1KE2 RAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
4500 4510 4520 4530 4540
>>CCDS43773.1 PLEC gene_id:5339|Hs109|chr8 (4547 aa)
initn: 28586 init1: 28586 opt: 28586 Z-score: 10584.0 bits: 1974.3 E(33420): 0
Smith-Waterman score: 28586; 100.0% identity (100.0% similar) in 4510 aa overlap (65-4574:38-4547)
40 50 60 70 80 90
pF1KE2 KTQRSRRSGGGAGSNGSVLDPAERAVIRIADERDRVQKKTFTKWVNKHLIKAQRHISDLY
::::::::::::::::::::::::::::::
CCDS43 FPSLVVVGHVVTLAAVWHWRRGRRWAQDEQDERDRVQKKTFTKWVNKHLIKAQRHISDLY
10 20 30 40 50 60
100 110 120 130 140 150
pF1KE2 EDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIAD
70 80 90 100 110 120
160 170 180 190 200 210
pF1KE2 GNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSW
130 140 150 160 170 180
220 230 240 250 260 270
pF1KE2 RDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPD
190 200 210 220 230 240
280 290 300 310 320 330
pF1KE2 EKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRF
250 260 270 280 290 300
340 350 360 370 380 390
pF1KE2 PSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 PSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVE
310 320 330 340 350 360
400 410 420 430 440 450
pF1KE2 KEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLA
370 380 390 400 410 420
460 470 480 490 500 510
pF1KE2 AGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE
430 440 450 460 470 480
520 530 540 550 560 570
pF1KE2 YNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVD
490 500 510 520 530 540
580 590 600 610 620 630
pF1KE2 LPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS
550 560 570 580 590 600
640 650 660 670 680 690
pF1KE2 SKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL
610 620 630 640 650 660
700 710 720 730 740 750
pF1KE2 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF
670 680 690 700 710 720
760 770 780 790 800 810
pF1KE2 FSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 FSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR
730 740 750 760 770 780
820 830 840 850 860 870
pF1KE2 AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS
790 800 810 820 830 840
880 890 900 910 920 930
pF1KE2 EAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIR
850 860 870 880 890 900
940 950 960 970 980 990
pF1KE2 SWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQ
910 920 930 940 950 960
1000 1010 1020 1030 1040 1050
pF1KE2 LLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ
970 980 990 1000 1010 1020
1060 1070 1080 1090 1100 1110
pF1KE2 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK
1030 1040 1050 1060 1070 1080
1120 1130 1140 1150 1160 1170
pF1KE2 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD
1090 1100 1110 1120 1130 1140
1180 1190 1200 1210 1220 1230
pF1KE2 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR
1150 1160 1170 1180 1190 1200
1240 1250 1260 1270 1280 1290
pF1KE2 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLQQEQALLEEIERHGEKVEE
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
CCDS43 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE
1210 1220 1230 1240 1250 1260
1300 1310 1320 1330 1340 1350
pF1KE2 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT
1270 1280 1290 1300 1310 1320
1360 1370 1380 1390 1400 1410
pF1KE2 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE
1330 1340 1350 1360 1370 1380
1420 1430 1440 1450 1460 1470
pF1KE2 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR
1390 1400 1410 1420 1430 1440
1480 1490 1500 1510 1520 1530
pF1KE2 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES
1450 1460 1470 1480 1490 1500
1540 1550 1560 1570 1580 1590
pF1KE2 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL
1510 1520 1530 1540 1550 1560
1600 1610 1620 1630 1640 1650
pF1KE2 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA
1570 1580 1590 1600 1610 1620
1660 1670 1680 1690 1700 1710
pF1KE2 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR
1630 1640 1650 1660 1670 1680
1720 1730 1740 1750 1760 1770
pF1KE2 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT
1690 1700 1710 1720 1730 1740
1780 1790 1800 1810 1820 1830
pF1KE2 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR
1750 1760 1770 1780 1790 1800
1840 1850 1860 1870 1880 1890
pF1KE2 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR
1810 1820 1830 1840 1850 1860
1900 1910 1920 1930 1940 1950
pF1KE2 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI
1870 1880 1890 1900 1910 1920
1960 1970 1980 1990 2000 2010
pF1KE2 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE
1930 1940 1950 1960 1970 1980
2020 2030 2040 2050 2060 2070
pF1KE2 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL
1990 2000 2010 2020 2030 2040
2080 2090 2100 2110 2120 2130
pF1KE2 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS
2050 2060 2070 2080 2090 2100
2140 2150 2160 2170 2180 2190
pF1KE2 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM
2110 2120 2130 2140 2150 2160
2200 2210 2220 2230 2240 2250
pF1KE2 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE
2170 2180 2190 2200 2210 2220
2260 2270 2280 2290 2300 2310
pF1KE2 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA
2230 2240 2250 2260 2270 2280
2320 2330 2340 2350 2360 2370
pF1KE2 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ
2290 2300 2310 2320 2330 2340
2380 2390 2400 2410 2420 2430
pF1KE2 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR
2350 2360 2370 2380 2390 2400
2440 2450 2460 2470 2480 2490
pF1KE2 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK
2410 2420 2430 2440 2450 2460
2500 2510 2520 2530 2540 2550
pF1KE2 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA
2470 2480 2490 2500 2510 2520
2560 2570 2580 2590 2600 2610
pF1KE2 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL
2530 2540 2550 2560 2570 2580
2620 2630 2640 2650 2660 2670
pF1KE2 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFD
2590 2600 2610 2620 2630 2640
2680 2690 2700 2710 2720 2730
pF1KE2 GLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATN
2650 2660 2670 2680 2690 2700
2740 2750 2760 2770 2780 2790
pF1KE2 EKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKL
2710 2720 2730 2740 2750 2760
2800 2810 2820 2830 2840 2850
pF1KE2 LSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD
2770 2780 2790 2800 2810 2820
2860 2870 2880 2890 2900 2910
pF1KE2 VAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDK
2830 2840 2850 2860 2870 2880
2920 2930 2940 2950 2960 2970
pF1KE2 AAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRT
2890 2900 2910 2920 2930 2940
2980 2990 3000 3010 3020 3030
pF1KE2 GRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSV
2950 2960 2970 2980 2990 3000
3040 3050 3060 3070 3080 3090
pF1KE2 RDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHI
3010 3020 3030 3040 3050 3060
3100 3110 3120 3130 3140 3150
pF1KE2 IDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 IDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPR
3070 3080 3090 3100 3110 3120
3160 3170 3180 3190 3200 3210
pF1KE2 EQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTG
3130 3140 3150 3160 3170 3180
3220 3230 3240 3250 3260 3270
pF1KE2 EPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFK
3190 3200 3210 3220 3230 3240
3280 3290 3300 3310 3320 3330
pF1KE2 GRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSG
3250 3260 3270 3280 3290 3300
3340 3350 3360 3370 3380 3390
pF1KE2 LRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKE
3310 3320 3330 3340 3350 3360
3400 3410 3420 3430 3440 3450
pF1KE2 KVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLL
3370 3380 3390 3400 3410 3420
3460 3470 3480 3490 3500 3510
pF1KE2 SAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDV
3430 3440 3450 3460 3470 3480
3520 3530 3540 3550 3560 3570
pF1KE2 AYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAE
3490 3500 3510 3520 3530 3540
3580 3590 3600 3610 3620 3630
pF1KE2 KAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMAD
3550 3560 3570 3580 3590 3600
3640 3650 3660 3670 3680 3690
pF1KE2 FQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 FQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLR
3610 3620 3630 3640 3650 3660
3700 3710 3720 3730 3740 3750
pF1KE2 EGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQ
3670 3680 3690 3700 3710 3720
3760 3770 3780 3790 3800 3810
pF1KE2 AATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMK
3730 3740 3750 3760 3770 3780
3820 3830 3840 3850 3860 3870
pF1KE2 KELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYV
3790 3800 3810 3820 3830 3840
3880 3890 3900 3910 3920 3930
pF1KE2 DPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEAT
3850 3860 3870 3880 3890 3900
3940 3950 3960 3970 3980 3990
pF1KE2 ALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELL
3910 3920 3930 3940 3950 3960
4000 4010 4020 4030 4040 4050
pF1KE2 EAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQ
3970 3980 3990 4000 4010 4020
4060 4070 4080 4090 4100 4110
pF1KE2 AMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDT
4030 4040 4050 4060 4070 4080
4120 4130 4140 4150 4160 4170
pF1KE2 KGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPE
4090 4100 4110 4120 4130 4140
4180 4190 4200 4210 4220 4230
pF1KE2 TGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDD
4150 4160 4170 4180 4190 4200
4240 4250 4260 4270 4280 4290
pF1KE2 AIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQL
4210 4220 4230 4240 4250 4260
4300 4310 4320 4330 4340 4350
pF1KE2 ASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTG
4270 4280 4290 4300 4310 4320
4360 4370 4380 4390 4400 4410
pF1KE2 ERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRF
4330 4340 4350 4360 4370 4380
4420 4430 4440 4450 4460 4470
pF1KE2 LEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYK
4390 4400 4410 4420 4430 4440
4480 4490 4500 4510 4520 4530
pF1KE2 DALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD
4450 4460 4470 4480 4490 4500
4540 4550 4560 4570
pF1KE2 ATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
::::::::::::::::::::::::::::::::::::::::
CCDS43 ATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
4510 4520 4530 4540
>>CCDS4959.1 DST gene_id:667|Hs109|chr6 (2649 aa)
initn: 3728 init1: 2412 opt: 3281 Z-score: 1233.5 bits: 243.4 E(33420): 2.2e-62
Smith-Waterman score: 3788; 29.7% identity (59.0% similar) in 2932 aa overlap (417-3241:56-2636)
390 400 410 420 430 440
pF1KE2 GYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALL
::: ::.:....: .. .::..: : :
CCDS49 DSNENLLLVHCGPTLINSCISFGSESFDGHRLEMLQQIANRVQRDSVICEDKLILAGNAL
30 40 50 60 70 80
450 460 470 480 490 500
pF1KE2 QSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHE
::: . : .: : .:. . . ....: ::: : ::.. :..:. .:: .:..
CCDS49 QSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRD
90 100 110 120 130 140
510 520
pF1KE2 RLVAIRTE----YN------------------LRLKAGVA--------------------
...:.:.: :. :..: :
CCDS49 EIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLT
150 160 170 180 190 200
530 540
pF1KE2 --------------------APA--------------TQVAQVTLQSVQ----RRPELED
.:: . : .::... :.: :..
CCDS49 SSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKS
210 220 230 240 250 260
550 560 570 580 590
pF1KE2 STL-----------RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF
: : ...:::: ::.: : ..: .::: ::::::..: .:...:..::::
CCDS49 SLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEF
270 280 290 300 310 320
600 610 620 630 640 650
pF1KE2 RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKE
......:. .: :.. . .: . : ::. :::::::.:. . : :..::.::. ::.:
CCDS49 ESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNE
330 340 350 360 370 380
660 670 680 690 700 710
pF1KE2 LMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP
:.::::::::::..:::.::::.. ::. .. :::::. ::..:: .:. ...:: :.::
CCDS49 LIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHP
390 400 410 420 430 440
720 730 740 750 760 770
pF1KE2 ARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRK
:: :.:...::.::::::.:::: :.: :.:::.:::.::.:..:: :..:..:..::
CCDS49 ARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRK
450 460 470 480 490 500
780 790 800 810 820 830
pF1KE2 YSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLP
::::::... .::::.:....:::.: .::. ...: .::...:::::. :.. .:
CCDS49 YSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIP
510 520 530 540 550 560
840 850 860 870 880 890
pF1KE2 LLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEA
. :.:::.:.:.:..: ::: :.. .. ..:::.: .:.:: :::::: :::::.:: .
CCDS49 IKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDL
570 580 590 600 610 620
900 910 920 930 940 950
pF1KE2 VTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHS
..:.: :.: ..::::. :..:::...:. : ... ::. ..:...:. : :..:.: .
CCDS49 ANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSN
630 640 650 660 670 680
960 970 980 990 1000 1010
pF1KE2 LELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISE
:. ... ::.:::.. :. : . :.: . :...::.::.: :. :::: . :::
CCDS49 LQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISE
690 700 710 720 730 740
1020 1030 1040 1050 1060 1070
pF1KE2 LKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE
...:::.:: :: : ....: ::... .: . ::.::.: . :.: : .. .. . :
CCDS49 VRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCE
750 760 770 780 790 800
1080 1090 1100 1110 1120 1130
pF1KE2 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH
. .. : ..:::::::...: ...:: :.:. :..::::..::...::.:: ... .
CCDS49 EFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLY
810 820 830 840 850 860
1140 1150 1160 1170 1180 1190
pF1KE2 EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG
: .: : .:: : ..: ..::. :.... .. .: ::.:::. :. ..... . .
CCDS49 ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYK
870 880 890 900 910 920
1200 1210 1220 1230 1240 1250
pF1KE2 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR
:::.. . .:.. ::.:::: : .: : : :.:: .:..:.:::.. :: :.:...
CCDS49 ERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVET
930 940 950 960 970 980
1260 1270 1280 1290 1300 1310
pF1KE2 RQEQIQAMPLADSQAVREQLQQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT
:..:: .:... ::.:.. :. ::: . :..:::..:.:: ..:::::: .:
CCDS49 TQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMT
990 1000 1010 1020 1030 1040
1320 1330 1340 1350 1360 1370
pF1KE2 YKAQLEPVA-SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE
:.:... ::.:. ..::... .:::..::::.:. :.:: .::::: ...:.:.:::
CCDS49 YRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEE
1050 1060 1070 1080 1090 1100
1380 1390 1400 1410 1420 1430
pF1KE2 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA
: .: .: . . :..:. : . ... . .::. :: :.
CCDS49 E----IKRCKETSEHGAYSDLLQRQK----ATVLENSKLTGKISELE-RMVAEL------
1110 1120 1130 1140 1150
1440 1450 1460 1470 1480 1490
pF1KE2 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ
..:: ..::: ..:...: :.. . :..: ...: : : . : .::. :.
CCDS49 ----KKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVRE
1160 1170 1180 1190 1200
1500 1510 1520 1530 1540 1550
pF1KE2 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA
. .:: ::. .: . ::::.. ..:. .: :..... .: : .: . . .
CCDS49 KEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDL
1210 1220 1230 1240 1250 1260
1560 1570 1580 1590 1600 1610
pF1KE2 AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE
..:.. .. :.. : . :: . ..: : . : : ::: . ... . ::...:
CCDS49 EQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARR-----
1270 1280 1290 1300 1310 1320
1620 1630 1640 1650 1660 1670
pF1KE2 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ
: .... . .:. . : . :: . ::
CCDS49 KITEIQYTCRENALPVCPIT---------QATSCRAV-----------------------
1330 1340
1680 1690 1700 1710 1720 1730
pF1KE2 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ
. : : .::: : : ..:. : :: .
CCDS49 --------TGLQQEHDKQKAE--------------------------ELKQQVDELTAAN
1350 1360 1370
1740 1750 1760 1770 1780 1790
pF1KE2 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL
: :::.. .: : . . : .. :: ::: .. : .: . : .. :.:
CCDS49 R-KAEQDMRELTYELN-ALQLEKTSSEEKARLLKD------KLDETNNTLRCLKLELE--
1380 1390 1400 1410 1420
1800 1810 1820 1830 1840 1850
pF1KE2 LASKARAEE-ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR
: .::. :.. : ..: :. .:. .: .::. :. . ::. :: :. .
CCDS49 --RKDQAEKGYSQQLRELGRQ-LNQTTGKAEEAMQEASDLKKI----KRNYQLELESLNH
1430 1440 1450 1460 1470
1860 1870 1880 1890 1900 1910
pF1KE2 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ
.... .: :. :. .: :. . : ... . ... ..: : :
CCDS49 EKGKLQR----------EVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERL----QICQ
1480 1490 1500 1510 1520
1920 1930 1940 1950 1960 1970
pF1KE2 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL
.:.: :: .:::
CCDS49 RKSD--------------------------------------HLKEQFEK----------
1530
1980 1990 2000 2010 2020 2030
pF1KE2 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA
:.:: ... :: .: ....:. .:: .. .
CCDS49 --------------SHEQL------LQNIKAE-----KENNDKIQR---LNEELEKSNEC
1540 1550 1560
2040 2050 2060 2070 2080 2090
pF1KE2 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ
: : :: :::: : :.. .:.. .:.::: . .. : .:. .
CCDS49 A----EMLKQKVEELTR------QNNETKLMM------QRIQAESENIVLEKQTIQQRCE
1570 1580 1590 1600 1610
2100 2110 2120 2130 2140 2150
pF1KE2 QTLQQEQSVLDQLRGEAEAARRAA--EEAEEARVQA-EREAAQSRRQVEEAERLKQSAEE
: .. ::::. : .. . :. . ... :.. :.:. : : .::. ..
CCDS49 ALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSE---FKQKCDQ
1620 1630 1640 1650 1660
2160 2170 2180 2190 2200
pF1KE2 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR-QKA
: . .. .::. : .:: : ... :. .:: .. :.:
CCDS49 Q-------NIIIQNTKKEV-----RNLNAELNASKEE----------KRRGEQKVQLQQA
1670 1680 1690 1700
2210 2220 2230 2240 2250 2260
pF1KE2 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK
:: :::.. .... : :.. .. .: . : . . .: ::. : .::.:
CCDS49 QV-QELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEF---RKKMEKL--
1710 1720 1730 1740 1750 1760
2270 2280 2290 2300 2310 2320
pF1KE2 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA
..... .:: .: : .. ::.: . :.: :.: . ...: :..:
CCDS49 MESKVITENDISGIR-LDFVS--LQQENSR----AQENAKLC-----ETNIKEL-ERQLQ
1770 1780 1790 1800
2330 2340 2350 2360 2370 2380
pF1KE2 QQRALAEKMLK-EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET
: : :.: . ..:.: . : : ::. :..:. .. :..: ::. :.
CCDS49 QYR---EQMQQGQHMEANHYQKCQKLEDELIAQKREV--------ENLKQKMDQQIKEH-
1810 1820 1830 1840 1850
2390 2400 2410 2420 2430 2440
pF1KE2 QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRT
..:: . :. .. . : :. : :. . : . : :
CCDS49 -----------EHQLVL------LQCEIQKKSTAK-----DCT-FKPDFEMTVKECQHSG
1860 1870 1880 1890
2450 2460 2470 2480 2490 2500
pF1KE2 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE--LEREKEKLQQEAKLLQLKSEEMQT
::.... : : . . .. . :.: . .:. ...: . :..:. :
CCDS49 ELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQ
1900 1910 1920 1930 1940 1950
2510 2520 2530 2540 2550 2560
pF1KE2 VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ
.: . : . :: .: .: . . :. : :: . . : .. : . :.
CCDS49 CYSEYFSQTSTELQITF-DETNPIT---RLSEIEKIRDQAL--------NNSRPPVRYQD
1960 1970 1980 1990 2000
2570 2580 2590 2600 2610 2620
pF1KE2 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL
. :.: .... .: :. .:.. . :. :.:.. :::
CCDS49 NACEMELVKVLTPLEIAKNKQYDM-------HTEVTTLKQEKNPVPS--AEE--------
2010 2020 2030 2040
2630 2640 2650 2660 2670 2680
pF1KE2 QLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA--EPEHSFDGLRRKVSAQ
. : :: : . .. :. . .:: : . . : .:.:::. :.:.
CCDS49 -WMLEGCRA----SGGLKKGDFLKKGLEPETFQNFDGDHACSVRDDEFKFQGLRHTVTAR
2050 2060 2070 2080 2090
2690 2700 2710 2720 2730 2740
pF1KE2 RLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAAL
.: :: .:. . ...: : ::.:. . . ..: .::::: :..:.::.: .:
CCDS49 QLVEAKLLDMRTIEQLRLGLKTVEEVQKT--LNKFLTKATSIAGLYLESTKEKISFASAA
2100 2110 2120 2130 2140 2150
2750 2760 2770 2780 2790 2800
pF1KE2 QRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTG
.: ... .:: .::::::.::..::. .. .:..:: .::: ::.. .:: ::.:..:
CCDS49 ERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVG
2160 2170 2180 2190 2200 2210
2810 2820 2830 2840 2850 2860
pF1KE2 YKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFD
:. :... .:.::::.. .. :..: ..::::::.:::::::.. ::: ..: ..: ..
CCDS49 YS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLN
2220 2230 2240 2250 2260 2270
2870 2880 2890 2900 2910 2920
pF1KE2 EEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVY
. . . : .::..:. : .::... : : .::. :: : :. :.:. ::
CCDS49 NAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPF-------GERNI
2280 2290 2300 2310 2320
2930 2940 2950 2960 2970 2980
pF1KE2 TDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKII
.. ... . . ..:.. :. .:..: . .:.:... ... ..
CCDS49 SNLNVKKTHRISVVDTK----TGSELTVYEAF---------QRNLIEKSIYLELSGQQYQ
2330 2340 2350 2360 2370
2990 3000 3010 3020 3030 3040
pF1KE2 KIIITVVEEQEQKGRLCFEGLRSL-VPAAELLESRVIDRELYQQLQRGERSVRDVAEVDT
: ..... . .: : .:. .::. : .. :.: .. ..:. .
CCDS49 WKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELAD-SL
2380 2390 2400 2410 2420 2430
3050 3060 3070 3080 3090
pF1KE2 VRRALRGANV---IAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPAT
. : . .. .:: :: .:...:. .: ...:. :. ::::..:: :::: :
CCDS49 LSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLT
2440 2450 2460 2470 2480 2490
3100 3110 3120 3130 3140 3150
pF1KE2 SARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLR
. . : ::.. ::: : ..: . : ..:: : :.. .:. .:.. ..: .:.:.:
CCDS49 GKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIR
2500 2510 2520 2530 2540 2550
3160 3170 3180 3190 3200 3210
pF1KE2 LLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATY
:. : :::...:. :. .. : : .: . :. .. .. :.: . ::
CCDS49 CLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTY
2560 2570 2580 2590 2600 2610
3220 3230 3240 3250 3260 3270
pF1KE2 GELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVT
: .. : :::.:: .::
CCDS49 KEALEKADFDFHTGLKLLEVSEPLMTGISSLYYSS
2620 2630 2640
>>CCDS435.1 MACF1 gene_id:23499|Hs109|chr1 (5430 aa)
initn: 3924 init1: 1689 opt: 2794 Z-score: 1049.3 bits: 210.3 E(33420): 4.1e-52
Smith-Waterman score: 4881; 29.5% identity (59.6% similar) in 4180 aa overlap (9-3935:24-4012)
10 20 30 40
pF1KE2 MSGEDAEVRAVSEDVSNGSSGSPSPGDTLPWNLGKTQRSRRSGGG
:. . :.. : : ::::::::: ....:.
CCDS43 MSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCP-PGDTLPWNLPLHEQKKRK---
10 20 30 40 50
50 60 70 80 90 100
pF1KE2 AGSNGSVLDPAERAVIRIADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLIS
:. ::::::::::.:.::::::::::::::::::::.:...::.::::::::::::::
CCDS43 --SQDSVLDPAERAVVRVADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLIS
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE2 LLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIW
::::::: .:::::::::::.:::::::::.:..:::::::::::::.::::::::::::
CCDS43 LLEVLSGIKLPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIW
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE2 TIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIH
::::::::::: .::.: ::.::::::::.:... :: :..: ::.: : ::..:::.::
CCDS43 TIILHFQISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIH
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE2 RHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSL
:..: :.::..: :.: :::.::: :::: :::::::: ::::::.:::::.::::::.
CCDS43 RYRPDLVDMERVQIQSNRENLEQAFEVAER-LGVTRLLDAEDVDVPSPDEKSVITYVSSI
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE2 YDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILW
:::.:.::. .:. :.:.. :::::. : :. :...:: . .. ::.. :.. :.
CCDS43 YDAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALY
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE2 SQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAIL
.:...::: :. ::: .:.: . .:. :: .. :..:.: :::: :::.::::: . .:
CCDS43 NQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEML
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE2 EREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEV
::::.:: :::: : .:..:.: : :::.:. : ::.:. : .:. : ..:
CCDS43 EREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDV
420 430 440 450 460 470
470 480 490 500 510 520
pF1KE2 ERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE-YNLRLKAGV-
... ...:: : :.: :.: . : :.. ::.::...::..: : :: :.
CCDS43 IMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFT
480 490 500 510 520 530
530 540 550
pF1KE2 ----------------AAPATQVAQVTLQSVQRRP----EL------ED-STLRYLQDLL
: : :.... . : :.: :: :: ..::.. .::
CCDS43 SLELVPPSTLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELL
540 550 560 570 580 590
560 570 580 590 600 610
pF1KE2 AWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGA
.:::: : ... :::: :::::: :: ... .: :.::. .....:: ::..: . .
CCDS43 SWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTS
600 610 620 630 640 650
620 630 640 650 660 670
pF1KE2 YRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNT
: . ::.:. :: :: ..:. :.: :.:::.::. :: ::.:::::::::...:::: :.
CCDS43 YAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNS
660 670 680 690 700 710
680 690 700 710 720 730
pF1KE2 NMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQ
:..::.. .: : ::: :. .. ::.... : :.:::. :::...::.:.: .:: :
CCDS43 NISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQ
720 730 740 750 760 770
740 750 760 770 780 790
pF1KE2 LCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQD
:: :.: :.:::.::::::::.:: :. :..::....::::::......::::::::..:
CCDS43 LCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMD
780 790 800 810 820 830
800 810 820 830 840 850
pF1KE2 EKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQ
::::: . :. ...:. :.:..:::::: : : ... . . :::::.:.:.:. :.:::
CCDS43 EKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECV
840 850 860 870 880 890
860 870 880 890 900 910
pF1KE2 LVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVD
: .: ..:::.: .:.:: :::::::.::::..: : ..:.: ..: ...:::::::.
CCDS43 LEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVN
900 910 920 930 940 950
920 930 940 950 960 970
pF1KE2 MKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPE
:::..:. ::.:..:...:.: .:. : : .: ...:. ::. ::.::.:. :.
CCDS43 TKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVA
960 970 980 990 1000 1010
980 990 1000 1010 1020 1030
pF1KE2 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL
::: :.: .:. ..:.:..:.:. .::. . :::::.:::.:: : :.:.:..
CCDS43 DRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQS
1020 1030 1040 1050 1060 1070
1040 1050 1060 1070 1080 1090
pF1KE2 ----PLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS
:.. .. : :::::...: ... : . . .: . .. : : ..:::::
CCDS43 LASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRS
1080 1090 1100 1110 1120 1130
1100 1110 1120 1130 1140 1150
pF1KE2 ELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL
::.: . :...: .::..::.::::.....:. : :: .....: .:.. ..: : : :
CCDS43 ELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSAL
1140 1150 1160 1170 1180 1190
1160 1170 1180 1190 1200 1210
pF1KE2 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL
:: ..:.. .... .. .:..: .:. :. :.:.... ::....::..:. .::
CCDS43 EAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQ
1200 1210 1220 1230 1240 1250
1220 1230 1240 1250 1260 1270
pF1KE2 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVR
:::. :.:: ..:: :::.. . : :: : :.... .::... ::...
CCDS43 ERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLS
1260 1270 1280 1290 1300 1310
1280 1290 1300 1310 1320 1330
pF1KE2 EQLQQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA-SPAKKPK
:::.:. ::. ::::. :...::.:..:: . .:::::::.:::: .: ::.:. .
CCDS43 EQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRR
1320 1330 1340 1350 1360 1370
1340 1350 1360 1370 1380 1390
pF1KE2 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE
. :.:... ::..::::.:. :.:::.:..:.::..:::.::::...:... :. :.. :
CCDS43 MLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKE
1380 1390 1400 1410 1420 1430
1400 1410 1420 1430
pF1KE2 VE---AALEKQRQLAEAHAQAKAQAEREAKEL-QQRMQEEVVRREEAAVDA---------
. ..: .. : . ...: ... : : :: ..::.. ..: . .:
CCDS43 LLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLA
1440 1450 1460 1470 1480 1490
1440 1450 1460 1470 1480
pF1KE2 -------QQQKRSIQEELQQLRQSSE-----AEIQAKARQAEAAERSRLR-IEEEIRVVR
...:..:.:.:. : .. . . : . :.. :.... . .... . .
CCDS43 KHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCH
1500 1510 1520 1530 1540 1550
1490 1500 1510 1520 1530 1540
pF1KE2 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA
::: : :: : . ..:. . : .: .. . ...::. : . . . ..
CCDS43 QQLEDLCSWVGQAERALAGHQGRTTQ---QDLSALQKNQSDLKDLQDDIQNRATSFATVV
1560 1570 1580 1590 1600 1610
1550 1560 1570 1580 1590
pF1KE2 SRVKAEAEAAREK--QRALQALEELRLQAEEA------ERRLRQAEVERARQVQVALETA
. ... : . : : : ::.: ::.: : :. : :.:.: . ::
CCDS43 KDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETE
1620 1630 1640 1650 1660 1670
1600 1610 1620 1630 1640
pF1KE2 QRSAEAEL-QSKR---------ASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQQAE
. .: :: ..:. .: . . .:: .: :... :.: :. : . ..
CCDS43 KSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASL----EKGALDTTD
1680 1690 1700 1710 1720
1650 1660 1670 1680 1690 1700
pF1KE2 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG-K
. . ..: ..:. : : .. : : : ..::... : :. .: . . ..
CCDS43 GYMGVNQAPEKLD----KQCEMMKARHQ-ELLSQQQNFILA---TQSAQAFLDQHGHNLT
1730 1740 1750 1760 1770
1710 1720 1730 1740 1750 1760
pF1KE2 AEEQAVRQRELAEQELEKQRQLAEGTAQ--QRLAAEQELIRLRAETEQGEQQRQLLEEEL
::: . :..:.: . . . .::.. :. : . ..:: .. . .. :. . :.::
CCDS43 PEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKEL
1780 1790 1800 1810 1820 1830
1770 1780 1790 1800 1810
pF1KE2 ARLQR-----EAAAATQKRQ-ELEAELAKVRAEMEVLLASKARAEE------ESRSTSEK
... :. . ::: . .. . ..... . : .. . :.. ::
CCDS43 ENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEI
1840 1850 1860 1870 1880 1890
1820 1830 1840 1850 1860
pF1KE2 S---KQRLEAEAGRFRELAEEAARLRA-----LAEEAKRQRQLAEEDAARQRAEA--ERV
. :..:. . :. : . .:: . :.. . : . .: : :: :..
CCDS43 GNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKL
1900 1910 1920 1930 1940 1950
1870 1880 1890 1900 1910
pF1KE2 LAEKLAAIGEATRLKTEAEIALKEKEAEN----ERLRRLAEDEAFQRRRLEEQAAQHKAD
:.. .:. . . . . :.:. ::. :.:...:.: ..: . : .
CCDS43 LSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIM----EIEGEPAPDHRH
1960 1970 1980 1990 2000 2010
1920 1930 1940 1950 1960 1970
pF1KE2 IEER----LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF---EKAAAGKAE
..: :..... : : ::.. :.. .. : ..:.: . .: :. :. ::
CCDS43 VQETTDSILSHFQSLSYSLAERSS-LLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQV
2020 2030 2040 2050 2060 2070
1980 1990 2000 2010
pF1KE2 LELELGRIRSNAEDTLR-----SKEQAELEAARQ----------RQLAAEEERRRREAEE
: : :. ... ..... :::.:. :: . . :. .
CCDS43 SSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQ
2080 2090 2100 2110 2120 2130
2020 2030 2040 2050 2060
pF1KE2 RVQKSLAAEEEAARQRKAALEEVE-------RLKAKVEEARRLRERAEQESARQLQLAQE
: .. ..: . : : ..: .:. .:. :. ..: . .. :.
CCDS43 RFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQ
2140 2150 2160 2170 2180 2190
2070 2080 2090 2100 2110 2120
pF1KE2 AAQKRLQAEEKAHAF-AVQQKEQELQQT-----LQQEQSVLDQLRGEAEAARRAAEEAEE
. :. :.. . . .... ::.. : :.:. ...:: . .....: :.
CCDS43 IQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREK
2200 2210 2220 2230 2240 2250
2130 2140 2150 2160 2170
pF1KE2 ARVQAEREAAQSRRQVEEAER-LKQSA-----EEQAQARAQAQAAAEKLRKEAEQEAARR
. ... . :. :. .. ::.. : ... . . :.:.. .. :..
CCDS43 DASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKG
2260 2270 2280 2290 2300 2310
2180 2190 2200 2210
pF1KE2 AQAEQAALRQKQAADAEME-----KHKKFAE---------------QTLRQKAQVEQELT
. .:. . . . :: .. : . .: .. .... ...
CCDS43 TLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMS
2320 2330 2340 2350 2360 2370
2220 2230 2240 2250 2260 2270
pF1KE2 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA
. :. :. . .: :: . . :. .. ..: . : : . : :... :
CCDS43 DVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLES---KEEVLKSMDAMSSP
2380 2390 2400 2410 2420 2430
2280 2290 2300 2310 2320 2330
pF1KE2 ENRALILRDKDNTQRFLQE---EAEKMKQVAEEAARLSVA---AQEAARLRQLAEEDLAQ
. . . .... :: : .. :...: : : : :. .::: ... :: ..
CCDS43 TKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSR
2440 2450 2460 2470 2480 2490
2340 2350 2360 2370 2380
pF1KE2 QRALAEKMLKEKMQAVQEATRLK----AEAELLQ--QQKELAQEQARRLQEDKEQMAQQL
. .: . .. : . :..: ::..: ..::: . :. : ... :
CCDS43 WERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQ-
2500 2510 2520 2530 2540
2390 2400 2410 2420 2430 2440
pF1KE2 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL
...: . . .::.::.. ... :. . ...: . ...... : . .. :. .::
CCDS43 KQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKL
2550 2560 2570 2580 2590 2600
2450 2460 2470 2480 2490 2500
pF1KE2 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE-KLQQEAKLLQLKSEEM
. ..: ..:.. . :. .: .:..: . .: .. . : :: ::.
CCDS43 NSR--SSQIDQAIVKSTQYQELLQDL-SEKVRAVGQRLSVQSAISTQPEAVKQQLEETSE
2610 2620 2630 2640 2650 2660
2510 2520 2530 2540 2550 2560
pF1KE2 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE-KAKLEQLFQDEVAKAQQLREEQQ
. ::: .:.. : : .. :.: :.....: : .:: :: : :.
CCDS43 IRSDLEQLDHEVKEAQT--LCDELSVLIGEQYLKDELKKRLET-----VALPLQGLED--
2670 2680 2690 2700 2710
2570 2580 2590 2600 2610 2620
pF1KE2 RQQQQMEQER-QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL
. .: .:: :.. ... :. .: .: .. :. :: .. .. . .::
CCDS43 -----LAADRINRLQAALASTQQFQQMFDE-LRTWLDDKQS--QQAKNCP--ISAKLERL
2720 2730 2740 2750 2760
2630 2640 2650 2660 2670
pF1KE2 REQLQLLEEQHRAALAHS---EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRR
. ::: :: ... :: : ..: . ..: :.. .: .. .. : .
CCDS43 QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK
2770 2780 2790 2800 2810 2820
2680 2690 2700 2710 2720 2730
pF1KE2 KVSAQ--RLQEAGILSAEELQRLAQGHTTV--DELARREDVRHYLQGRSSIAGLLL-KAT
:.. . ::.. . .:.. : .. . : :. ..: :. . ..:: ::
CCDS43 KTADRQSRLKDC-MQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAM
2830 2840 2850 2860 2870 2880
2740 2750 2760 2770 2780 2790
pF1KE2 NEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHK
... .: . : : .: ::.... :. : .:... .:. . .: ::. :
CCDS43 LNEVEKRRSLLEILNS--AADILINSSEADE---DGIRDEKAGINQNM--DAVTEELQAK
2890 2900 2910 2920 2930
2800 2810 2820 2830 2840 2850
pF1KE2 LLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEA---QIATGGVIDPVHSHR
: :. . .. : : :. ..: . .: .....: : .. .. .....
CCDS43 TGSLEEMTQRLRE----FQES-FKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQ
2940 2950 2960 2970 2980 2990
2860 2870 2880 2890 2900
pF1KE2 -----VPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETG
. .: : :. : . . . : :: .. . . .. .. .:.. .: ..:
CCDS43 EVLQALEPQVDYLRN-FTQGLVEDAPDGSDASQLLHQAEVAQQ-EFLEVKQRV----NSG
3000 3010 3020 3030 3040
2910 2920 2930 2940 2950 2960
pF1KE2 LCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQR
:.. . .: :.. ..:..: . : . .: . .: :.
CCDS43 -CVM-MENKLEGIGQF---HCRVREMFSQL---ADLDDELDGMGAIGRDTDSLQSQIEDV
3050 3060 3070 3080 3090 3100
2970 2980 2990 3000 3010 3020
pF1KE2 RDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDR----
: .: .... .. .: ..::. : : . ::. . : . ... .:
CCDS43 RLFLNKIHVLKLDIEASEAECRHMLEEE---GTLDLLGLKRELEALNKQCGKLTERGKAR
3110 3120 3130 3140 3150
3030 3040 3050 3060 3070
pF1KE2 --ELYQQLQRGE---RSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLL
.: : : : :... . .. :. . .. . ..:. .: .:.:. .. ..:. .
CCDS43 QEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQV
3160 3170 3180 3190 3200 3210
3080 3090 3100 3110 3120 3130
pF1KE2 -PSDMAVALLEAQAGTGH-IIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRD
: .: :. : :. .:. : . : :. : : . ..:. . . .
CCDS43 DPLQMK---LQQVNGLGQGLIQSAGK-----DCDVQ----GLEHDMEEINARWNTLNKK-
3220 3230 3240 3250 3260
3140 3150 3160 3170 3180 3190
pF1KE2 PYTGQSVSLFQALKKGLIPREQGLRLLDAQLS-TGGIVDPSKSHRVPLDVACARGCLDEE
..: .. .: ...:. : . :. : .. .: . :. :. ..
CCDS43 --VAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL
3270 3280 3290 3300 3310 3320
3200 3210 3220 3230 3240 3250
pF1KE2 TSRALSAPRADAKAYSDPSTGEPATYGELQQRCR-PDQLTGLS--LLPLSEKAARARQEE
.: :. .: . . . :. : .:: .: . :: .: : ::: :::..
CCDS43 LQRLLDDRKATVDMLQAEG-GRIAQSAELADREKITGQLESLESRWTELLSKAA-ARQKQ
3330 3340 3350 3360 3370 3380
3260 3270 3280 3290 3300
pF1KE2 LYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYF---TAEQRQELLRQFRTGKVT
: . : . :..: :.. : .:: .: .:: ::. .:...:. .
CCDS43 LEDILVLAKQFHETAE--PISDFL--SVTEKKLANSEPVGTQTAKIQQQIIRH-----KA
3390 3400 3410 3420 3430
3310 3320 3330 3340 3350 3360
pF1KE2 VEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKD
.:. :. : :... . : :.:.: .:. .::::. ....:. . ..:
CCDS43 LEEDIENHATDVHQAVKIGQ---SLSSLTSPAE------QGVLSE-KIDSLQARYSEIQD
3440 3450 3460 3470 3480
3370 3380 3390 3400 3410 3420
pF1KE2 LSELGSVRTLLQGSGCLAGIYLEDTKEKVS----IYEAMRRGLLRATTAALLLEAQAATG
.. ::. . : .. :: : .. . . . ... .: . .:
CCDS43 RCCRKAA--LLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHL
3490 3500 3510 3520 3530
3430 3440 3450 3460 3470 3480
pF1KE2 FLVDPVRNQRLYVHEAVKAG--VVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKG
: . . :.. : .:.: : .. :..: .. . : . :. :.. .:..
CCDS43 ALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTL
3540 3550 3560 3570 3580 3590
3490 3500 3510 3520
pF1KE2 LVLRQHG-------------IRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEM-NR
:: . .: .: ..::.: .:. ....: :. .: : .:
CCDS43 EQARQLATKFQSTYEELTGWLREVEEELATSGGQSPT-GEQIPQFQQRQKELKKEVMEHR
3600 3610 3620 3630 3640 3650
3530 3540 3550 3560 3570 3580
pF1KE2 VLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTE
.. : .... : ::: . :: : . :. ..: :
CCDS43 LVLDTVNEVS-------------RALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRV
3660 3670 3680 3690 3700
3590 3600 3610 3620 3630 3640
pF1KE2 EETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMII
.: :....: ..... : . : .: .::: .
CCDS43 DEIDAAIQRSQ-----QYEQAADAELAW-------VAETKR-KLMA-----------LGP
3710 3720 3730 3740
3650 3660 3670 3680 3690 3700
pF1KE2 IIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEAR--IISL---ETYNLLREGTRSLRE
: .: . : .. : : : .:.. . ..:: : :.. : ..:.: :.:: .
CCDS43 IRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQ
3750 3760 3770 3780 3790 3800
3710 3720 3730 3740 3750
pF1KE2 ALEAESAW-CYLYGTGSVAGVYLPG---SRQTLSIY----QALKKGLLSAEVARLLLEAQ
:: : :. : : . . . :: . .:: : : . . :. :
CCDS43 QYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQ
3810 3820 3830 3840 3850 3860
3760 3770 3780 3790 3800 3810
pF1KE2 AATGFLL-DPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAM
: . . .. .:. .. .::.:.. :. :.. .. : ... ... .
CCDS43 QEEMRQLRESIAEHKPHIDKLLK---IGPQLKE--LNPEEGEM-VEEKY-QKAENMYAQI
3870 3880 3890 3900 3910
3820 3830 3840 3850 3860 3870
pF1KE2 KKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSY
:.:. ..:: : .: . :.. :: .: . .. ..: : . .
CCDS43 KEEV--RQRALALDEAVSQSTQITE----FHDKIEPMLETL---ENLSSRLRMPPLIPAE
3920 3930 3940 3950 3960
3880 3890 3900 3910 3920 3930
pF1KE2 VDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELV-RSQVMDE
:: .:.: :. .. . : . . .:..:... :::. ::: :.
CCDS43 VDK-----------IRECISDNKSATVEL---EKLQPSFEALKRR--GEELIGRSQGADK
3970 3980 3990 4000
3940 3950 3960 3970 3980 3990
pF1KE2 ATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFE
:
CCDS43 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIV
4010 4020 4030 4040 4050 4060
4574 residues in 1 query sequences
18921897 residues in 33420 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Jul 3 20:41:28 2020 done: Fri Jul 3 20:41:30 2020
Total Scan time: 6.660 Total Display time: 4.740
Function used was FASTA [36.3.4 Apr, 2011]