Result of FASTA (omim) for
pF1KE2525
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2525, 522 aa
1>>>pF1KE2525 522 - 522 aa - 522 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.9197+/-0.000319; mu= 16.2220+/- 0.020
mean_var=85.1945+/-17.161, 0's: 0 Z-trim(116.1): 23 B-trim: 0 in 0/58
Lambda= 0.138953
statistics sampled from 27005 (27027) to 27005 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.657), E-opt: 0.2 (0.317), width: 16
Scan time: 8.190
The best scores are: opt bits E(85289)
NP_000628 (OMIM: 138300) glutathione reductase, mi ( 522) 3440 699.5 6.4e-201
NP_001182032 (OMIM: 138300) glutathione reductase, ( 469) 1949 400.6 5.5e-111
NP_001182033 (OMIM: 138300) glutathione reductase, ( 440) 1783 367.3 5.5e-101
NP_001182031 (OMIM: 138300) glutathione reductase, ( 493) 1774 365.5 2.1e-100
NP_006431 (OMIM: 606448) thioredoxin reductase 2, ( 524) 962 202.7 2.2e-51
NP_001248375 (OMIM: 601112) thioredoxin reductase ( 461) 841 178.4 4e-44
NP_877419 (OMIM: 601112) thioredoxin reductase 1, ( 499) 841 178.4 4.2e-44
NP_877393 (OMIM: 601112) thioredoxin reductase 1, ( 499) 841 178.4 4.2e-44
NP_877420 (OMIM: 601112) thioredoxin reductase 1, ( 499) 841 178.4 4.2e-44
NP_001248374 (OMIM: 601112) thioredoxin reductase ( 549) 841 178.5 4.6e-44
NP_003321 (OMIM: 601112) thioredoxin reductase 1, ( 551) 841 178.5 4.6e-44
NP_001087240 (OMIM: 601112) thioredoxin reductase ( 649) 841 178.5 5.3e-44
NP_443115 (OMIM: 606235) thioredoxin reductase 3 i ( 643) 812 172.7 2.9e-42
NP_000099 (OMIM: 238331,246900) dihydrolipoyl dehy ( 509) 648 139.8 1.9e-32
NP_001166984 (OMIM: 606235) thioredoxin reductase ( 607) 529 116.0 3.4e-25
NP_001276680 (OMIM: 238331,246900) dihydrolipoyl d ( 486) 487 107.5 9.6e-23
NP_001276679 (OMIM: 238331,246900) dihydrolipoyl d ( 410) 480 106.0 2.2e-22
NP_001276681 (OMIM: 238331,246900) dihydrolipoyl d ( 461) 452 100.4 1.2e-20
NP_001269441 (OMIM: 606448) thioredoxin reductase ( 338) 444 98.8 2.8e-20
>>NP_000628 (OMIM: 138300) glutathione reductase, mitoch (522 aa)
initn: 3440 init1: 3440 opt: 3440 Z-score: 3728.2 bits: 699.5 E(85289): 6.4e-201
Smith-Waterman score: 3440; 100.0% identity (100.0% similar) in 522 aa overlap (1-522:1-522)
10 20 30 40 50 60
pF1KE2 MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 EFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ
430 440 450 460 470 480
490 500 510 520
pF1KE2 GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
::::::::::::::::::::::::::::::::::::::::::
NP_000 GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
490 500 510 520
>>NP_001182032 (OMIM: 138300) glutathione reductase, mit (469 aa)
initn: 3084 init1: 1949 opt: 1949 Z-score: 2113.5 bits: 400.6 E(85289): 5.5e-111
Smith-Waterman score: 2982; 89.8% identity (89.8% similar) in 522 aa overlap (1-522:1-469)
10 20 30 40 50 60
pF1KE2 MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 EFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQ------
250 260 270 280 290
310 320 330 340 350 360
pF1KE2 TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD
:::::::::::::
NP_001 -----------------------------------------------GIQTDDKGHIIVD
300
370 380 390 400 410 420
pF1KE2 EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP
310 320 330 340 350 360
430 440 450 460 470 480
pF1KE2 IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ
370 380 390 400 410 420
490 500 510 520
pF1KE2 GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
::::::::::::::::::::::::::::::::::::::::::
NP_001 GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
430 440 450 460
>>NP_001182033 (OMIM: 138300) glutathione reductase, mit (440 aa)
initn: 1858 init1: 1770 opt: 1783 Z-score: 1934.1 bits: 367.3 E(85289): 5.5e-101
Smith-Waterman score: 2744; 84.3% identity (84.3% similar) in 522 aa overlap (1-522:1-440)
10 20 30 40 50 60
pF1KE2 MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 EFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK
:::::::::::::::::::::::::
NP_001 YIAVEMAGILSALGSKTSLMIRHDK-----------------------------------
250 260
310 320 330 340 350 360
pF1KE2 TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD
:::::::::::::
NP_001 -----------------------------------------------GIQTDDKGHIIVD
270
370 380 390 400 410 420
pF1KE2 EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP
280 290 300 310 320 330
430 440 450 460 470 480
pF1KE2 IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ
340 350 360 370 380 390
490 500 510 520
pF1KE2 GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
::::::::::::::::::::::::::::::::::::::::::
NP_001 GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
400 410 420 430 440
>>NP_001182031 (OMIM: 138300) glutathione reductase, mit (493 aa)
initn: 1808 init1: 1774 opt: 1774 Z-score: 1923.6 bits: 365.5 E(85289): 2.1e-100
Smith-Waterman score: 3192; 94.4% identity (94.4% similar) in 522 aa overlap (1-522:1-493)
10 20 30 40 50 60
pF1KE2 MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 EFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK
:::::::::::::::::::::::::: :::::
NP_001 YIAVEMAGILSALGSKTSLMIRHDKV-----------------------------KEVKK
250 260 270
310 320 330 340 350 360
pF1KE2 TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE2 IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ
400 410 420 430 440 450
490 500 510 520
pF1KE2 GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
::::::::::::::::::::::::::::::::::::::::::
NP_001 GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
460 470 480 490
>>NP_006431 (OMIM: 606448) thioredoxin reductase 2, mito (524 aa)
initn: 629 init1: 190 opt: 962 Z-score: 1043.5 bits: 202.7 E(85289): 2.2e-51
Smith-Waterman score: 1068; 39.9% identity (68.8% similar) in 484 aa overlap (58-522:33-508)
30 40 50 60 70 80
pF1KE2 LLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELG
::.. .:: ::.:::::::: :..::.::
NP_006 AMAVALRGLGGRFRWRTQAVAGGVRGAARGAAAGQRDYDLLVVGGGSGGLACAKEAAQLG
10 20 30 40 50 60
90 100 110 120 130
pF1KE2 ARAAVVESHK---------LGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEG-K
..:::. . ::::::::::.:::.: ..:. . ...: .::. .
NP_006 RKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGLIQDAPNYGWEVAQPVP
70 80 90 100 110 120
140 150 160 170 180 190
pF1KE2 FNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKK---YTAP
.:: . : . .:. :: .. .: ... . .:.:... ..: : .:
NP_006 HDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVDEHTVCGVAKGGKEILLSAD
130 140 150 160 170 180
200 210 220 230 240 250
pF1KE2 HILIATGGMPSTPHESQIPGA-SLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSAL
::.::::: : : ..: :: ::::: .: :.: ::....:::.:.:.: ::.:...
NP_006 HIIIATGGRPRYP--THIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGI
190 200 210 220 230 240
260 270 280 290 300 310
pF1KE2 GSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSG-LEVSMVTA
: :..:.: . ::.::...:. :.. . :.. :. ..:.. .: :.:. .
NP_006 GLDTTIMMR-SIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTWEDS
250 260 270 280 290
320 330 340 350 360 370
pF1KE2 VPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTD-DKGHIIVDEFQNTNVKGIY
. :. . :. : .::::::::.:..:.:.: :..:. : .:.:: . :.: ::
NP_006 TTGKEDTGTF----DTVLWAIGRVPDTRSLNLEKAGVDTSPDTQKILVDSREATSVPHIY
300 310 320 330 340 350
380 390 400 410 420 430
pF1KE2 AVGDVC-GKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDE
:.::: :. :::.:: ::: :..::: . : .::.:.::.::. : :::.:.:
NP_006 AIGDVVEGRPELTPIAIMAGRLLVQRLFGGSSDL-MDYDNVPTTVFTPLEYGCVGLSEEE
360 370 380 390 400 410
440 450 460 470 480
pF1KE2 AIHKYGIENVKTYSTSFTPMYHAVTKRK-TKCVMKMVCANKEEKVV-GIHMQGLGCDEML
:. ..: :.:..: . . :. .:. : ..: .:::: . ..: :.:. : . :.
NP_006 AVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLREPPQLVLGLHFLGPNAGEVT
420 430 440 450 460 470
490 500 510 520
pF1KE2 QGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
::::...: ::. :. ::.:::: :::.: ::
NP_006 QGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKRSGLDPTVTGCCG
480 490 500 510 520
>>NP_001248375 (OMIM: 601112) thioredoxin reductase 1, c (461 aa)
initn: 468 init1: 202 opt: 841 Z-score: 913.2 bits: 178.4 E(85289): 4e-44
Smith-Waterman score: 842; 35.7% identity (67.6% similar) in 442 aa overlap (98-521:17-444)
70 80 90 100 110 120
pF1KE2 LVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHA
::::::::::.:::.: ..:. .. ..:
NP_001 MVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSR
10 20 30 40
130 140 150 160 170 180
pF1KE2 DYGFPSCEG-KFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPK-PTIE
.::. : : .: . : . ... :: :. : .... ... : . . . .
NP_001 NYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATN
50 60 70 80 90 100
190 200 210 220 230 240
pF1KE2 VSGKK--YTAPHILIATGGMPSTPHESQIPGAS-LGITSDGFFQLEELPGRSVIVGAGYI
.::. :.: ..::::: :. ::: . :.:: .:.: ::....:::.:.
NP_001 NKGKEKIYSAERFLIATG---ERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYV
110 120 130 140 150 160
250 260 270 280 290 300
pF1KE2 AVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLK-FSQVKEVKKT
:.: ::.:...: ...:.: . .::.::. .... :..:. :.. .. : .: :..
NP_001 ALECAGFLAGIGLDVTVMVR-SILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIK-VEQI
170 180 190 200 210 220
310 320 330 340 350
pF1KE2 LSGLEVSMVTAVPGRLPVMTMIPD--------VDCLLWAIGRVPNTKDLSLNKLGIQTDD
.: .:::: :... . . .. :::: :. ..:. .:.. ..
NP_001 EAG--------TPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINE
230 240 250 260 270
360 370 380 390 400 410
pF1KE2 K-GHIIVDEFQNTNVKGIYAVGDVC-GKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNI
: :.: : . ..::: :::.::. :. :::::: ::: ::.::. . : ::.:.
NP_001 KTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGST-VKCDYENV
280 290 300 310 320 330
420 430 440 450 460 470
pF1KE2 PTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKR-KTKCVMKMVCANK
::.::. :. ::.:..:..:.: ::...: . : :. .. .: ..:: :..: .:
NP_001 PTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTK
340 350 360 370 380 390
480 490 500 510 520
pF1KE2 E-EKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
. :.:::.:. : . :. ::::.:.: : :: ..:.:..:::. .: ..::
NP_001 DNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGA
400 410 420 430 440 450
NP_001 SILQAGCCG
460
>>NP_877419 (OMIM: 601112) thioredoxin reductase 1, cyto (499 aa)
initn: 572 init1: 202 opt: 841 Z-score: 912.7 bits: 178.4 E(85289): 4.2e-44
Smith-Waterman score: 926; 36.0% identity (67.1% similar) in 484 aa overlap (65-521:13-482)
40 50 60 70 80 90
pF1KE2 ALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVE
:: ..:::::::::.:..::. : .. :..
NP_877 MNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLD
10 20 30 40
100 110 120 130 140
pF1KE2 ---------SHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEG-KFNWRVIK
::::::::::.:::.: ..:. .. ..: .::. : : .: .
NP_877 FVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKVEETVKHDWDRMI
50 60 70 80 90 100
150 160 170 180 190 200
pF1KE2 EKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPK-PTIEVSGKK--YTAPHILIATG
: . ... :: :. : .... ... : . . . . .::. :.: ..:::::
NP_877 EAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATG
110 120 130 140 150 160
210 220 230 240 250 260
pF1KE2 GMPSTPHESQIPGAS-LGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLM
:. ::: . :.:: .:.: ::....:::.:.:.: ::.:...: ...:
NP_877 ---ERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVM
170 180 190 200 210
270 280 290 300 310
pF1KE2 IRHDKVLRSFDSMISTNCTEELENAGVEVLK-FSQVKEVKKTLSGLEVSMVTAVPGRLPV
.: . .::.::. .... :..:. :.. .. : .: :.. .: .:::: :
NP_877 VR-SILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIK-VEQIEAG--------TPGRLRV
220 230 240 250 260
320 330 340 350 360 370
pF1KE2 MTMIPD--------VDCLLWAIGRVPNTKDLSLNKLGIQTDDK-GHIIVDEFQNTNVKGI
... . . .. :::: :. ..:. .:.. ..: :.: : . ..::: :
NP_877 VAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYI
270 280 290 300 310 320
380 390 400 410 420
pF1KE2 YAVGDVC-GKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTED
::.::. :. :::::: ::: ::.::. . : ::.:.::.::. :. ::.:.
NP_877 YAIGDILEDKVELTPVAIQAGRLLAQRLYAGST-VKCDYENVPTTVFTPLEYGACGLSEE
330 340 350 360 370 380
430 440 450 460 470 480
pF1KE2 EAIHKYGIENVKTYSTSFTPMYHAVTKR-KTKCVMKMVCANKE-EKVVGIHMQGLGCDEM
.:..:.: ::...: . : :. .. .: ..:: :..: .:. :.:::.:. : . :.
NP_877 KAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEV
390 400 410 420 430 440
490 500 510 520
pF1KE2 LQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
::::.:.: : :: ..:.:..:::. .: ..::
NP_877 TQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCCG
450 460 470 480 490
>>NP_877393 (OMIM: 601112) thioredoxin reductase 1, cyto (499 aa)
initn: 572 init1: 202 opt: 841 Z-score: 912.7 bits: 178.4 E(85289): 4.2e-44
Smith-Waterman score: 926; 36.0% identity (67.1% similar) in 484 aa overlap (65-521:13-482)
40 50 60 70 80 90
pF1KE2 ALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVE
:: ..:::::::::.:..::. : .. :..
NP_877 MNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLD
10 20 30 40
100 110 120 130 140
pF1KE2 ---------SHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEG-KFNWRVIK
::::::::::.:::.: ..:. .. ..: .::. : : .: .
NP_877 FVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKVEETVKHDWDRMI
50 60 70 80 90 100
150 160 170 180 190 200
pF1KE2 EKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPK-PTIEVSGKK--YTAPHILIATG
: . ... :: :. : .... ... : . . . . .::. :.: ..:::::
NP_877 EAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATG
110 120 130 140 150 160
210 220 230 240 250 260
pF1KE2 GMPSTPHESQIPGAS-LGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLM
:. ::: . :.:: .:.: ::....:::.:.:.: ::.:...: ...:
NP_877 ---ERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVM
170 180 190 200 210
270 280 290 300 310
pF1KE2 IRHDKVLRSFDSMISTNCTEELENAGVEVLK-FSQVKEVKKTLSGLEVSMVTAVPGRLPV
.: . .::.::. .... :..:. :.. .. : .: :.. .: .:::: :
NP_877 VR-SILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIK-VEQIEAG--------TPGRLRV
220 230 240 250 260
320 330 340 350 360 370
pF1KE2 MTMIPD--------VDCLLWAIGRVPNTKDLSLNKLGIQTDDK-GHIIVDEFQNTNVKGI
... . . .. :::: :. ..:. .:.. ..: :.: : . ..::: :
NP_877 VAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYI
270 280 290 300 310 320
380 390 400 410 420
pF1KE2 YAVGDVC-GKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTED
::.::. :. :::::: ::: ::.::. . : ::.:.::.::. :. ::.:.
NP_877 YAIGDILEDKVELTPVAIQAGRLLAQRLYAGST-VKCDYENVPTTVFTPLEYGACGLSEE
330 340 350 360 370 380
430 440 450 460 470 480
pF1KE2 EAIHKYGIENVKTYSTSFTPMYHAVTKR-KTKCVMKMVCANKE-EKVVGIHMQGLGCDEM
.:..:.: ::...: . : :. .. .: ..:: :..: .:. :.:::.:. : . :.
NP_877 KAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEV
390 400 410 420 430 440
490 500 510 520
pF1KE2 LQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
::::.:.: : :: ..:.:..:::. .: ..::
NP_877 TQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCCG
450 460 470 480 490
>>NP_877420 (OMIM: 601112) thioredoxin reductase 1, cyto (499 aa)
initn: 572 init1: 202 opt: 841 Z-score: 912.7 bits: 178.4 E(85289): 4.2e-44
Smith-Waterman score: 926; 36.0% identity (67.1% similar) in 484 aa overlap (65-521:13-482)
40 50 60 70 80 90
pF1KE2 ALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVE
:: ..:::::::::.:..::. : .. :..
NP_877 MNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLD
10 20 30 40
100 110 120 130 140
pF1KE2 ---------SHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEG-KFNWRVIK
::::::::::.:::.: ..:. .. ..: .::. : : .: .
NP_877 FVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKVEETVKHDWDRMI
50 60 70 80 90 100
150 160 170 180 190 200
pF1KE2 EKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPK-PTIEVSGKK--YTAPHILIATG
: . ... :: :. : .... ... : . . . . .::. :.: ..:::::
NP_877 EAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATG
110 120 130 140 150 160
210 220 230 240 250 260
pF1KE2 GMPSTPHESQIPGAS-LGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLM
:. ::: . :.:: .:.: ::....:::.:.:.: ::.:...: ...:
NP_877 ---ERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVM
170 180 190 200 210
270 280 290 300 310
pF1KE2 IRHDKVLRSFDSMISTNCTEELENAGVEVLK-FSQVKEVKKTLSGLEVSMVTAVPGRLPV
.: . .::.::. .... :..:. :.. .. : .: :.. .: .:::: :
NP_877 VR-SILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIK-VEQIEAG--------TPGRLRV
220 230 240 250 260
320 330 340 350 360 370
pF1KE2 MTMIPD--------VDCLLWAIGRVPNTKDLSLNKLGIQTDDK-GHIIVDEFQNTNVKGI
... . . .. :::: :. ..:. .:.. ..: :.: : . ..::: :
NP_877 VAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYI
270 280 290 300 310 320
380 390 400 410 420
pF1KE2 YAVGDVC-GKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTED
::.::. :. :::::: ::: ::.::. . : ::.:.::.::. :. ::.:.
NP_877 YAIGDILEDKVELTPVAIQAGRLLAQRLYAGST-VKCDYENVPTTVFTPLEYGACGLSEE
330 340 350 360 370 380
430 440 450 460 470 480
pF1KE2 EAIHKYGIENVKTYSTSFTPMYHAVTKR-KTKCVMKMVCANKE-EKVVGIHMQGLGCDEM
.:..:.: ::...: . : :. .. .: ..:: :..: .:. :.:::.:. : . :.
NP_877 KAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEV
390 400 410 420 430 440
490 500 510 520
pF1KE2 LQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
::::.:.: : :: ..:.:..:::. .: ..::
NP_877 TQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCCG
450 460 470 480 490
>>NP_001248374 (OMIM: 601112) thioredoxin reductase 1, c (549 aa)
initn: 572 init1: 202 opt: 841 Z-score: 912.1 bits: 178.5 E(85289): 4.6e-44
Smith-Waterman score: 926; 36.0% identity (67.1% similar) in 484 aa overlap (65-521:63-532)
40 50 60 70 80 90
pF1KE2 ALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVE
:: ..:::::::::.:..::. : .. :..
NP_001 HGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLD
40 50 60 70 80 90
100 110 120 130 140
pF1KE2 ---------SHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEG-KFNWRVIK
::::::::::.:::.: ..:. .. ..: .::. : : .: .
NP_001 FVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKVEETVKHDWDRMI
100 110 120 130 140 150
150 160 170 180 190 200
pF1KE2 EKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPK-PTIEVSGKK--YTAPHILIATG
: . ... :: :. : .... ... : . . . . .::. :.: ..:::::
NP_001 EAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATG
160 170 180 190 200 210
210 220 230 240 250 260
pF1KE2 GMPSTPHESQIPGAS-LGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLM
:. ::: . :.:: .:.: ::....:::.:.:.: ::.:...: ...:
NP_001 ---ERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVM
220 230 240 250 260
270 280 290 300 310
pF1KE2 IRHDKVLRSFDSMISTNCTEELENAGVEVLK-FSQVKEVKKTLSGLEVSMVTAVPGRLPV
.: . .::.::. .... :..:. :.. .. : .: :.. .: .:::: :
NP_001 VR-SILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIK-VEQIEAG--------TPGRLRV
270 280 290 300 310
320 330 340 350 360 370
pF1KE2 MTMIPD--------VDCLLWAIGRVPNTKDLSLNKLGIQTDDK-GHIIVDEFQNTNVKGI
... . . .. :::: :. ..:. .:.. ..: :.: : . ..::: :
NP_001 VAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYI
320 330 340 350 360 370
380 390 400 410 420
pF1KE2 YAVGDVC-GKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTED
::.::. :. :::::: ::: ::.::. . : ::.:.::.::. :. ::.:.
NP_001 YAIGDILEDKVELTPVAIQAGRLLAQRLYAGST-VKCDYENVPTTVFTPLEYGACGLSEE
380 390 400 410 420 430
430 440 450 460 470 480
pF1KE2 EAIHKYGIENVKTYSTSFTPMYHAVTKR-KTKCVMKMVCANKE-EKVVGIHMQGLGCDEM
.:..:.: ::...: . : :. .. .: ..:: :..: .:. :.:::.:. : . :.
NP_001 KAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEV
440 450 460 470 480 490
490 500 510 520
pF1KE2 LQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
::::.:.: : :: ..:.:..:::. .: ..::
NP_001 TQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCCG
500 510 520 530 540
522 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 03:31:27 2016 done: Tue Nov 8 03:31:29 2016
Total Scan time: 8.190 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]