Result of FASTA (omim) for pF1KE3196
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE3196, 470 aa
  1>>>pF1KE3196     470 - 470 aa - 470 aa
Library: /omim/omim.rfq.tfa
  64369986 residues in 92320 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.6004+/-0.000296; mu= 13.9480+/- 0.019
 mean_var=141.8534+/-28.594, 0's: 0 Z-trim(120.8): 42  B-trim: 0 in 0/56
 Lambda= 0.107685
 statistics sampled from 37975 (38017) to 37975 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.746), E-opt: 0.2 (0.412), width:  16
 Scan time:  5.140

The best scores are:                                      opt bits E(92320)
NP_892010 (OMIM: 603730) sphingosine kinase 1 isof ( 470) 3206 509.5 8.8e-144
NP_001342068 (OMIM: 603730) sphingosine kinase 1 i ( 384) 2611 416.9 5.1e-116
NP_001136074 (OMIM: 603730) sphingosine kinase 1 i ( 384) 2611 416.9 5.1e-116
NP_001136073 (OMIM: 603730) sphingosine kinase 1 i ( 384) 2611 416.9 5.1e-116
NP_068807 (OMIM: 603730) sphingosine kinase 1 isof ( 398) 2586 413.1 7.8e-115
NP_001191087 (OMIM: 607092) sphingosine kinase 2 i ( 595)  851 143.7 1.4e-33
NP_001191089 (OMIM: 607092) sphingosine kinase 2 i ( 618)  851 143.7 1.5e-33
XP_006723355 (OMIM: 607092) sphingosine kinase 2 i ( 618)  851 143.7 1.5e-33
XP_011525436 (OMIM: 607092) sphingosine kinase 2 i ( 618)  851 143.7 1.5e-33
XP_011525435 (OMIM: 607092) sphingosine kinase 2 i ( 654)  851 143.7 1.5e-33
NP_064511 (OMIM: 607092) sphingosine kinase 2 isof ( 654)  851 143.7 1.5e-33
NP_001191088 (OMIM: 607092) sphingosine kinase 2 i ( 654)  851 143.7 1.5e-33
XP_016882497 (OMIM: 607092) sphingosine kinase 2 i ( 716)  851 143.8 1.6e-33
NP_001230805 (OMIM: 607092) sphingosine kinase 2 i ( 448)  730 124.8 5.3e-28
XP_016882499 (OMIM: 607092) sphingosine kinase 2 i ( 401)  472 84.7 5.7e-16
XP_016884398 (OMIM: 610307) ceramide kinase isofor ( 500)  320 61.1 8.6e-09
NP_073603 (OMIM: 610307) ceramide kinase [Homo sap ( 537)  320 61.2   9e-09
NP_001351877 (OMIM: 212350,610345,614691) acylglyc ( 350)  278 54.5 6.1e-07
XP_011514699 (OMIM: 212350,610345,614691) acylglyc ( 422)  278 54.5   7e-07
XP_024302603 (OMIM: 212350,610345,614691) acylglyc ( 422)  278 54.5   7e-07
NP_060708 (OMIM: 212350,610345,614691) acylglycero ( 422)  278 54.5   7e-07
NP_963842 (OMIM: 608380,608381) ceramide kinase-li ( 532)  199 42.4  0.0041


>>NP_892010 (OMIM: 603730) sphingosine kinase 1 isoform   (470 aa)
 initn: 3206 init1: 3206 opt: 3206  Z-score: 2702.9  bits: 509.5 E(92320): 8.8e-144
Smith-Waterman score: 3206; 100.0% identity (100.0% similar) in 470 aa overlap (1-470:1-470)

               10        20        30        40        50        60
pF1KE3 MSAQVLGFLRSWTPLPLAAPRGPAAAGNDAGAPAATAPGGEGEPHSRPCDARLGSTDKEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_892 MSAQVLGFLRSWTPLPLAAPRGPAAAGNDAGAPAATAPGGEGEPHSRPCDARLGSTDKEL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE3 KAGAAATGSAPTAPGTPWQREPRVEVMDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_892 KAGAAATGSAPTAPGTPWQREPRVEVMDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLF
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE3 RSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_892 RSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMER
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE3 PDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_892 PDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE3 LHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_892 LHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLP
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE3 VGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_892 VGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE3 APMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_892 APMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDG
              370       380       390       400       410       420

              430       440       450       460       470
pF1KE3 KGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_892 KGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL
              430       440       450       460       470

>>NP_001342068 (OMIM: 603730) sphingosine kinase 1 isofo  (384 aa)
 initn: 2611 init1: 2611 opt: 2611  Z-score: 2204.5  bits: 416.9 E(92320): 5.1e-116
Smith-Waterman score: 2611; 100.0% identity (100.0% similar) in 384 aa overlap (87-470:1-384)

         60        70        80        90       100       110      
pF1KE3 DKELKAGAAATGSAPTAPGTPWQREPRVEVMDPAGGPRGVLPRPCRVLVLLNPRGGKGKA
                                     ::::::::::::::::::::::::::::::
NP_001                               MDPAGGPRGVLPRPCRVLVLLNPRGGKGKA
                                             10        20        30

        120       130       140       150       160       170      
pF1KE3 LQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNG
               40        50        60        70        80        90

        180       190       200       210       220       230      
pF1KE3 LMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPM
              100       110       120       130       140       150

        240       250       260       270       280       290      
pF1KE3 NLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRL
              160       170       180       190       200       210

        300       310       320       330       340       350      
pF1KE3 AYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGS
              220       230       240       250       260       270

        360       370       380       390       400       410      
pF1KE3 EMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLE
              280       290       300       310       320       330

        420       430       440       450       460       470
pF1KE3 PKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL
              340       350       360       370       380    

>>NP_001136074 (OMIM: 603730) sphingosine kinase 1 isofo  (384 aa)
 initn: 2611 init1: 2611 opt: 2611  Z-score: 2204.5  bits: 416.9 E(92320): 5.1e-116
Smith-Waterman score: 2611; 100.0% identity (100.0% similar) in 384 aa overlap (87-470:1-384)

         60        70        80        90       100       110      
pF1KE3 DKELKAGAAATGSAPTAPGTPWQREPRVEVMDPAGGPRGVLPRPCRVLVLLNPRGGKGKA
                                     ::::::::::::::::::::::::::::::
NP_001                               MDPAGGPRGVLPRPCRVLVLLNPRGGKGKA
                                             10        20        30

        120       130       140       150       160       170      
pF1KE3 LQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNG
               40        50        60        70        80        90

        180       190       200       210       220       230      
pF1KE3 LMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPM
              100       110       120       130       140       150

        240       250       260       270       280       290      
pF1KE3 NLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRL
              160       170       180       190       200       210

        300       310       320       330       340       350      
pF1KE3 AYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGS
              220       230       240       250       260       270

        360       370       380       390       400       410      
pF1KE3 EMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLE
              280       290       300       310       320       330

        420       430       440       450       460       470
pF1KE3 PKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL
              340       350       360       370       380    

>>NP_001136073 (OMIM: 603730) sphingosine kinase 1 isofo  (384 aa)
 initn: 2611 init1: 2611 opt: 2611  Z-score: 2204.5  bits: 416.9 E(92320): 5.1e-116
Smith-Waterman score: 2611; 100.0% identity (100.0% similar) in 384 aa overlap (87-470:1-384)

         60        70        80        90       100       110      
pF1KE3 DKELKAGAAATGSAPTAPGTPWQREPRVEVMDPAGGPRGVLPRPCRVLVLLNPRGGKGKA
                                     ::::::::::::::::::::::::::::::
NP_001                               MDPAGGPRGVLPRPCRVLVLLNPRGGKGKA
                                             10        20        30

        120       130       140       150       160       170      
pF1KE3 LQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNG
               40        50        60        70        80        90

        180       190       200       210       220       230      
pF1KE3 LMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPM
              100       110       120       130       140       150

        240       250       260       270       280       290      
pF1KE3 NLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRL
              160       170       180       190       200       210

        300       310       320       330       340       350      
pF1KE3 AYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGS
              220       230       240       250       260       270

        360       370       380       390       400       410      
pF1KE3 EMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLE
              280       290       300       310       320       330

        420       430       440       450       460       470
pF1KE3 PKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL
              340       350       360       370       380    

>>NP_068807 (OMIM: 603730) sphingosine kinase 1 isoform   (398 aa)
 initn: 2586 init1: 2586 opt: 2586  Z-score: 2183.3  bits: 413.1 E(92320): 7.8e-115
Smith-Waterman score: 2586; 100.0% identity (100.0% similar) in 381 aa overlap (90-470:18-398)

      60        70        80        90       100       110         
pF1KE3 LKAGAAATGSAPTAPGTPWQREPRVEVMDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQL
                                     ::::::::::::::::::::::::::::::
NP_068              MDPVVGCGRGLFGFVFSAGGPRGVLPRPCRVLVLLNPRGGKGKALQL
                            10        20        30        40       

     120       130       140       150       160       170         
pF1KE3 FRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 FRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLME
        50        60        70        80        90       100       

     180       190       200       210       220       230         
pF1KE3 RPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 RPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLL
       110       120       130       140       150       160       

     240       250       260       270       280       290         
pF1KE3 SLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 SLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYL
       170       180       190       200       210       220       

     300       310       320       330       340       350         
pF1KE3 PVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 PVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMF
       230       240       250       260       270       280       

     360       370       380       390       400       410         
pF1KE3 AAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 AAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKD
       290       300       310       320       330       340       

     420       430       440       450       460       470
pF1KE3 GKGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL
       :::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 GKGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL
       350       360       370       380       390        

>>NP_001191087 (OMIM: 607092) sphingosine kinase 2 isofo  (595 aa)
 initn: 1166 init1: 827 opt: 851  Z-score: 724.3  bits: 143.7 E(92320): 1.4e-33
Smith-Waterman score: 859; 44.6% identity (68.5% similar) in 336 aa overlap (14-332:22-350)

                       10        20           30        40         
pF1KE3         MSAQVLGFLRSWTPLPLAAPRG---PAAAGNDAGAPAATAPGGEGE------
                            : : : :::   : :  .   .  . .:.  .       
NP_001 MNGHLEAEEQQDQALHIQRLRPKPEARPRGGLVPLAEVSGCCTLRSRSPSDSAAYFCIYT
               10        20        30        40        50        60

             50        60        70        80           90         
pF1KE3 -PHSRPCDARLGSTDKELKAGAAATGSAPTAPGTPWQREPRVEVMD---PAGG---PRGV
        :..:   ::  .: . ..: .:::     : .  :       .     :. :   :  .
NP_001 YPRGRR-GARRRAT-RTFRADGAATYEENRAEAQRWATALTCLLRGLPLPGDGEITP-DL
                70         80        90       100       110        

        100       110       120       130       140       150      
pF1KE3 LPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELG
       :::: :.:.:.:: ::.: : :  ..:: :...:: .::.:. :::.:::::::..  :.
NP_001 LPRPPRLLLLVNPFGGRGLAWQWCKNHVLPMISEAGLSFNLIQTERQNHARELVQGLSLS
       120       130       140       150       160       170       

        160       170       180       190       200       210      
pF1KE3 RWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVT
       .::..:..:::::.:::.:::..::::: :.. :.  :: :::::::...:...:.: . 
NP_001 EWDGIVTVSGDGLLHEVLNGLLDRPDWEEAVKMPVGILPCGSGNALAGAVNQHGGFEPAL
       180       190       200       210       220       230       

        220       230       240       250       260       270      
pF1KE3 NEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEM
       . ::: ::.:::::    :..:::.  ::: : :: ::.::::..:::..::..: ::  
NP_001 GLDLLLNCSLLLCRGGGHPLDLLSVTLASGSRCFSFLSVAWGFVSDVDIQSERFRALGSA
       240       250       260       270       280       290       

        280       290       300       310        320       330     
pF1KE3 RFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGP-VDAHLVPLEEPVPSHW
       :::::: : ::.:.::::::.:::.    .  ::::. ... : . ..:.   .:.:   
NP_001 RFTLGTVLGLATLHTYRGRLSYLPA----TVEPASPTPAHSLPRAKSELTLTPDPAPPMA
       300       310       320           330       340       350   

         340       350       360       370       380       390     
pF1KE3 TVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKG
                                                                   
NP_001 HSPLHRSVSDLPLPLPQPALASPGSPEPLPILSLNGGGPELAGDWGGAGDAPLSPDPLLS
           360       370       380       390       400       410   

>--
 initn: 417 init1: 353 opt: 423  Z-score: 365.0  bits: 77.2 E(92320): 1.5e-13
Smith-Waterman score: 423; 45.4% identity (66.3% similar) in 163 aa overlap (300-460:445-595)

     270       280       290       300       310       320         
pF1KE3 YRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEE
                                     : .:::..:         :: :  : ::  
NP_001 PPGSPKAALHSPVSEGAPVIPPSSGLPLPTPDARVGAST--------CGPPDHLLPPLGT
          420       430       440       450               460      

     330       340       350       360       370       380         
pF1KE3 PVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLF
       :.:  : :. . ::::.::.  ::::... ::: .:   :..:: .::.:.::: :::::
NP_001 PLPPDW-VTLEGDFVLMLAISPSHLGADLVAAPHARFDDGLVHLCWVRSGISRAALLRLF
        470        480       490       500       510       520     

     390       400       410       420       430       440         
pF1KE3 LAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVS
       ::::.: :.   :: : :. . ::::::   .::..:::: .    .:.:.::.   ...
NP_001 LAMERGSHFSLGCPQLGYAAARAFRLEPLTPRGVLTVDGEQVEYGPLQAQMHPGIGTLLT
         530       540       550       560       570       580     

     450         460       470
pF1KE3 GCVEPP--PSWKPQQMPPPEEPL
       :   ::  :. .:          
NP_001 G---PPGCPGREP          
            590               

>>NP_001191089 (OMIM: 607092) sphingosine kinase 2 isofo  (618 aa)
 initn: 1166 init1: 827 opt: 851  Z-score: 724.1  bits: 143.7 E(92320): 1.5e-33
Smith-Waterman score: 865; 43.8% identity (68.2% similar) in 349 aa overlap (1-332:33-373)

                                             10        20          
pF1KE3                               MSAQVLGFLRSWTPLPLAAPRG---PAAAG
                                     ...:.: . :   : : : :::   : :  
NP_001 PPPPPLAASTPLLHGEFGSYPARGPRFALTLTSQALHIQR-LRPKPEARPRGGLVPLAEV
             10        20        30        40         50        60 

        30        40               50        60        70        80
pF1KE3 NDAGAPAATAPGGEGE-------PHSRPCDARLGSTDKELKAGAAATGSAPTAPGTPWQR
       .   .  . .:.  .        :..:   ::  .: . ..: .:::     : .  :  
NP_001 SGCCTLRSRSPSDSAAYFCIYTYPRGRR-GARRRAT-RTFRADGAATYEENRAEAQRWAT
              70        80         90        100       110         

                  90          100       110       120       130    
pF1KE3 EPRVEVMD---PAGG---PRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEIS
            .     :. :   :  .:::: :.:.:.:: ::.: : :  ..:: :...:: .:
NP_001 ALTCLLRGLPLPGDGEITP-DLLPRPPRLLLLVNPFGGRGLAWQWCKNHVLPMISEAGLS
     120       130        140       150       160       170        

          140       150       160       170       180       190    
pF1KE3 FTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSL
       :.:. :::.:::::::..  :..::..:..:::::.:::.:::..::::: :.. :.  :
NP_001 FNLIQTERQNHARELVQGLSLSEWDGIVTVSGDGLLHEVLNGLLDRPDWEEAVKMPVGIL
      180       190       200       210       220       230        

          200       210       220       230       240       250    
pF1KE3 PAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLS
       : :::::::...:...:.: . . ::: ::.:::::    :..:::.  ::: : :: ::
NP_001 PCGSGNALAGAVNQHGGFEPALGLDLLLNCSLLLCRGGGHPLDLLSVTLASGSRCFSFLS
      240       250       260       270       280       290        

          260       270       280       290       300       310    
pF1KE3 LAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVV
       .::::..:::..::..: ::  :::::: : ::.:.::::::.:::.    .  ::::. 
NP_001 VAWGFVSDVDIQSERFRALGSARFTLGTVLGLATLHTYRGRLSYLPA----TVEPASPTP
      300       310       320       330       340           350    

           320       330       340       350       360       370   
pF1KE3 VQQGP-VDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHL
       ... : . ..:.   .:.:                                         
NP_001 AHSLPRAKSELTLTPDPAPPMAHSPLHRSVSDLPLPLPQPALASPGSPEPLPILSLNGGG
          360       370       380       390       400       410    

>--
 initn: 417 init1: 353 opt: 423  Z-score: 364.7  bits: 77.2 E(92320): 1.5e-13
Smith-Waterman score: 423; 45.4% identity (66.3% similar) in 163 aa overlap (300-460:468-618)

     270       280       290       300       310       320         
pF1KE3 YRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEE
                                     : .:::..:         :: :  : ::  
NP_001 PPGSPKAALHSPVSEGAPVIPPSSGLPLPTPDARVGAST--------CGPPDHLLPPLGT
       440       450       460       470               480         

     330       340       350       360       370       380         
pF1KE3 PVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLF
       :.:  : :. . ::::.::.  ::::... ::: .:   :..:: .::.:.::: :::::
NP_001 PLPPDW-VTLEGDFVLMLAISPSHLGADLVAAPHARFDDGLVHLCWVRSGISRAALLRLF
     490        500       510       520       530       540        

     390       400       410       420       430       440         
pF1KE3 LAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVS
       ::::.: :.   :: : :. . ::::::   .::..:::: .    .:.:.::.   ...
NP_001 LAMERGSHFSLGCPQLGYAAARAFRLEPLTPRGVLTVDGEQVEYGPLQAQMHPGIGTLLT
      550       560       570       580       590       600        

     450         460       470
pF1KE3 GCVEPP--PSWKPQQMPPPEEPL
       :   ::  :. .:          
NP_001 G---PPGCPGREP          
         610                  

>>XP_006723355 (OMIM: 607092) sphingosine kinase 2 isofo  (618 aa)
 initn: 1166 init1: 827 opt: 851  Z-score: 724.1  bits: 143.7 E(92320): 1.5e-33
Smith-Waterman score: 865; 43.8% identity (68.2% similar) in 349 aa overlap (1-332:33-373)

                                             10        20          
pF1KE3                               MSAQVLGFLRSWTPLPLAAPRG---PAAAG
                                     ...:.: . :   : : : :::   : :  
XP_006 PPPPPLAASTPLLHGEFGSYPARGPRFALTLTSQALHIQR-LRPKPEARPRGGLVPLAEV
             10        20        30        40         50        60 

        30        40               50        60        70        80
pF1KE3 NDAGAPAATAPGGEGE-------PHSRPCDARLGSTDKELKAGAAATGSAPTAPGTPWQR
       .   .  . .:.  .        :..:   ::  .: . ..: .:::     : .  :  
XP_006 SGCCTLRSRSPSDSAAYFCIYTYPRGRR-GARRRAT-RTFRADGAATYEENRAEAQRWAT
              70        80         90        100       110         

                  90          100       110       120       130    
pF1KE3 EPRVEVMD---PAGG---PRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEIS
            .     :. :   :  .:::: :.:.:.:: ::.: : :  ..:: :...:: .:
XP_006 ALTCLLRGLPLPGDGEITP-DLLPRPPRLLLLVNPFGGRGLAWQWCKNHVLPMISEAGLS
     120       130        140       150       160       170        

          140       150       160       170       180       190    
pF1KE3 FTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSL
       :.:. :::.:::::::..  :..::..:..:::::.:::.:::..::::: :.. :.  :
XP_006 FNLIQTERQNHARELVQGLSLSEWDGIVTVSGDGLLHEVLNGLLDRPDWEEAVKMPVGIL
      180       190       200       210       220       230        

          200       210       220       230       240       250    
pF1KE3 PAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLS
       : :::::::...:...:.: . . ::: ::.:::::    :..:::.  ::: : :: ::
XP_006 PCGSGNALAGAVNQHGGFEPALGLDLLLNCSLLLCRGGGHPLDLLSVTLASGSRCFSFLS
      240       250       260       270       280       290        

          260       270       280       290       300       310    
pF1KE3 LAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVV
       .::::..:::..::..: ::  :::::: : ::.:.::::::.:::.    .  ::::. 
XP_006 VAWGFVSDVDIQSERFRALGSARFTLGTVLGLATLHTYRGRLSYLPA----TVEPASPTP
      300       310       320       330       340           350    

           320       330       340       350       360       370   
pF1KE3 VQQGP-VDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHL
       ... : . ..:.   .:.:                                         
XP_006 AHSLPRAKSELTLTPDPAPPMAHSPLHRSVSDLPLPLPQPALASPGSPEPLPILSLNGGG
          360       370       380       390       400       410    

>--
 initn: 417 init1: 353 opt: 423  Z-score: 364.7  bits: 77.2 E(92320): 1.5e-13
Smith-Waterman score: 423; 45.4% identity (66.3% similar) in 163 aa overlap (300-460:468-618)

     270       280       290       300       310       320         
pF1KE3 YRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEE
                                     : .:::..:         :: :  : ::  
XP_006 PPGSPKAALHSPVSEGAPVIPPSSGLPLPTPDARVGAST--------CGPPDHLLPPLGT
       440       450       460       470               480         

     330       340       350       360       370       380         
pF1KE3 PVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLF
       :.:  : :. . ::::.::.  ::::... ::: .:   :..:: .::.:.::: :::::
XP_006 PLPPDW-VTLEGDFVLMLAISPSHLGADLVAAPHARFDDGLVHLCWVRSGISRAALLRLF
     490        500       510       520       530       540        

     390       400       410       420       430       440         
pF1KE3 LAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVS
       ::::.: :.   :: : :. . ::::::   .::..:::: .    .:.:.::.   ...
XP_006 LAMERGSHFSLGCPQLGYAAARAFRLEPLTPRGVLTVDGEQVEYGPLQAQMHPGIGTLLT
      550       560       570       580       590       600        

     450         460       470
pF1KE3 GCVEPP--PSWKPQQMPPPEEPL
       :   ::  :. .:          
XP_006 G---PPGCPGREP          
         610                  

>>XP_011525436 (OMIM: 607092) sphingosine kinase 2 isofo  (618 aa)
 initn: 1166 init1: 827 opt: 851  Z-score: 724.1  bits: 143.7 E(92320): 1.5e-33
Smith-Waterman score: 865; 43.8% identity (68.2% similar) in 349 aa overlap (1-332:33-373)

                                             10        20          
pF1KE3                               MSAQVLGFLRSWTPLPLAAPRG---PAAAG
                                     ...:.: . :   : : : :::   : :  
XP_011 PPPPPLAASTPLLHGEFGSYPARGPRFALTLTSQALHIQR-LRPKPEARPRGGLVPLAEV
             10        20        30        40         50        60 

        30        40               50        60        70        80
pF1KE3 NDAGAPAATAPGGEGE-------PHSRPCDARLGSTDKELKAGAAATGSAPTAPGTPWQR
       .   .  . .:.  .        :..:   ::  .: . ..: .:::     : .  :  
XP_011 SGCCTLRSRSPSDSAAYFCIYTYPRGRR-GARRRAT-RTFRADGAATYEENRAEAQRWAT
              70        80         90        100       110         

                  90          100       110       120       130    
pF1KE3 EPRVEVMD---PAGG---PRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEIS
            .     :. :   :  .:::: :.:.:.:: ::.: : :  ..:: :...:: .:
XP_011 ALTCLLRGLPLPGDGEITP-DLLPRPPRLLLLVNPFGGRGLAWQWCKNHVLPMISEAGLS
     120       130        140       150       160       170        

          140       150       160       170       180       190    
pF1KE3 FTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSL
       :.:. :::.:::::::..  :..::..:..:::::.:::.:::..::::: :.. :.  :
XP_011 FNLIQTERQNHARELVQGLSLSEWDGIVTVSGDGLLHEVLNGLLDRPDWEEAVKMPVGIL
      180       190       200       210       220       230        

          200       210       220       230       240       250    
pF1KE3 PAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLS
       : :::::::...:...:.: . . ::: ::.:::::    :..:::.  ::: : :: ::
XP_011 PCGSGNALAGAVNQHGGFEPALGLDLLLNCSLLLCRGGGHPLDLLSVTLASGSRCFSFLS
      240       250       260       270       280       290        

          260       270       280       290       300       310    
pF1KE3 LAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVV
       .::::..:::..::..: ::  :::::: : ::.:.::::::.:::.    .  ::::. 
XP_011 VAWGFVSDVDIQSERFRALGSARFTLGTVLGLATLHTYRGRLSYLPA----TVEPASPTP
      300       310       320       330       340           350    

           320       330       340       350       360       370   
pF1KE3 VQQGP-VDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHL
       ... : . ..:.   .:.:                                         
XP_011 AHSLPRAKSELTLTPDPAPPMAHSPLHRSVSDLPLPLPQPALASPGSPEPLPILSLNGGG
          360       370       380       390       400       410    

>--
 initn: 417 init1: 353 opt: 423  Z-score: 364.7  bits: 77.2 E(92320): 1.5e-13
Smith-Waterman score: 423; 45.4% identity (66.3% similar) in 163 aa overlap (300-460:468-618)

     270       280       290       300       310       320         
pF1KE3 YRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEE
                                     : .:::..:         :: :  : ::  
XP_011 PPGSPKAALHSPVSEGAPVIPPSSGLPLPTPDARVGAST--------CGPPDHLLPPLGT
       440       450       460       470               480         

     330       340       350       360       370       380         
pF1KE3 PVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLF
       :.:  : :. . ::::.::.  ::::... ::: .:   :..:: .::.:.::: :::::
XP_011 PLPPDW-VTLEGDFVLMLAISPSHLGADLVAAPHARFDDGLVHLCWVRSGISRAALLRLF
     490        500       510       520       530       540        

     390       400       410       420       430       440         
pF1KE3 LAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVS
       ::::.: :.   :: : :. . ::::::   .::..:::: .    .:.:.::.   ...
XP_011 LAMERGSHFSLGCPQLGYAAARAFRLEPLTPRGVLTVDGEQVEYGPLQAQMHPGIGTLLT
      550       560       570       580       590       600        

     450         460       470
pF1KE3 GCVEPP--PSWKPQQMPPPEEPL
       :   ::  :. .:          
XP_011 G---PPGCPGREP          
         610                  

>>XP_011525435 (OMIM: 607092) sphingosine kinase 2 isofo  (654 aa)
 initn: 1190 init1: 827 opt: 851  Z-score: 723.8  bits: 143.7 E(92320): 1.5e-33
Smith-Waterman score: 865; 43.8% identity (68.2% similar) in 349 aa overlap (1-332:69-409)

                                             10        20          
pF1KE3                               MSAQVLGFLRSWTPLPLAAPRG---PAAAG
                                     ...:.: . :   : : : :::   : :  
XP_011 PPPPPLAASTPLLHGEFGSYPARGPRFALTLTSQALHIQR-LRPKPEARPRGGLVPLAEV
       40        50        60        70         80        90       

        30        40               50        60        70        80
pF1KE3 NDAGAPAATAPGGEGE-------PHSRPCDARLGSTDKELKAGAAATGSAPTAPGTPWQR
       .   .  . .:.  .        :..:   ::  .: . ..: .:::     : .  :  
XP_011 SGCCTLRSRSPSDSAAYFCIYTYPRGRR-GARRRAT-RTFRADGAATYEENRAEAQRWAT
       100       110       120        130        140       150     

                  90          100       110       120       130    
pF1KE3 EPRVEVMD---PAGG---PRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEIS
            .     :. :   :  .:::: :.:.:.:: ::.: : :  ..:: :...:: .:
XP_011 ALTCLLRGLPLPGDGEITP-DLLPRPPRLLLLVNPFGGRGLAWQWCKNHVLPMISEAGLS
         160       170        180       190       200       210    

          140       150       160       170       180       190    
pF1KE3 FTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSL
       :.:. :::.:::::::..  :..::..:..:::::.:::.:::..::::: :.. :.  :
XP_011 FNLIQTERQNHARELVQGLSLSEWDGIVTVSGDGLLHEVLNGLLDRPDWEEAVKMPVGIL
          220       230       240       250       260       270    

          200       210       220       230       240       250    
pF1KE3 PAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLS
       : :::::::...:...:.: . . ::: ::.:::::    :..:::.  ::: : :: ::
XP_011 PCGSGNALAGAVNQHGGFEPALGLDLLLNCSLLLCRGGGHPLDLLSVTLASGSRCFSFLS
          280       290       300       310       320       330    

          260       270       280       290       300       310    
pF1KE3 LAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVV
       .::::..:::..::..: ::  :::::: : ::.:.::::::.:::.    .  ::::. 
XP_011 VAWGFVSDVDIQSERFRALGSARFTLGTVLGLATLHTYRGRLSYLPA----TVEPASPTP
          340       350       360       370       380           390

           320       330       340       350       360       370   
pF1KE3 VQQGP-VDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHL
       ... : . ..:.   .:.:                                         
XP_011 AHSLPRAKSELTLTPDPAPPMAHSPLHRSVSDLPLPLPQPALASPGSPEPLPILSLNGGG
              400       410       420       430       440       450

>--
 initn: 417 init1: 353 opt: 423  Z-score: 364.4  bits: 77.2 E(92320): 1.6e-13
Smith-Waterman score: 423; 45.4% identity (66.3% similar) in 163 aa overlap (300-460:504-654)

     270       280       290       300       310       320         
pF1KE3 YRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEE
                                     : .:::..:         :: :  : ::  
XP_011 PPGSPKAALHSPVSEGAPVIPPSSGLPLPTPDARVGAST--------CGPPDHLLPPLGT
           480       490       500       510               520     

     330       340       350       360       370       380         
pF1KE3 PVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLF
       :.:  : :. . ::::.::.  ::::... ::: .:   :..:: .::.:.::: :::::
XP_011 PLPPDW-VTLEGDFVLMLAISPSHLGADLVAAPHARFDDGLVHLCWVRSGISRAALLRLF
         530        540       550       560       570       580    

     390       400       410       420       430       440         
pF1KE3 LAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVS
       ::::.: :.   :: : :. . ::::::   .::..:::: .    .:.:.::.   ...
XP_011 LAMERGSHFSLGCPQLGYAAARAFRLEPLTPRGVLTVDGEQVEYGPLQAQMHPGIGTLLT
          590       600       610       620       630       640    

     450         460       470
pF1KE3 GCVEPP--PSWKPQQMPPPEEPL
       :   ::  :. .:          
XP_011 G---PPGCPGREP          
             650              




470 residues in 1 query   sequences
64369986 residues in 92320 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Oct 24 21:47:45 2019 done: Thu Oct 24 21:47:46 2019
 Total Scan time:  5.140 Total Display time:  0.080

Function used was FASTA [36.3.4 Apr, 2011]
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