FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2443, 321 aa 1>>>pF1KE2443 321 - 321 aa - 321 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.5324+/-0.000376; mu= 10.7181+/- 0.024 mean_var=108.5991+/-22.039, 0's: 0 Z-trim(116.3): 49 B-trim: 1412 in 2/48 Lambda= 0.123073 statistics sampled from 27248 (27298) to 27248 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.674), E-opt: 0.2 (0.32), width: 16 Scan time: 7.820 The best scores are: opt bits E(85289) NP_065711 (OMIM: 607058) gap junction delta-2 prot ( 321) 2145 391.4 1.3e-108 XP_016877927 (OMIM: 607058) PREDICTED: gap junctio ( 270) 1833 335.9 5.5e-92 NP_689343 (OMIM: 607425) gap junction delta-3 prot ( 294) 433 87.4 4e-17 XP_011507719 (OMIM: 116200,600897,612474) PREDICTE ( 427) 433 87.5 5.4e-17 NP_005258 (OMIM: 116200,600897,612474) gap junctio ( 433) 433 87.5 5.4e-17 XP_011507718 (OMIM: 116200,600897,612474) PREDICTE ( 433) 433 87.5 5.4e-17 XP_016856532 (OMIM: 121012) PREDICTED: gap junctio ( 333) 428 86.5 8.1e-17 XP_005270807 (OMIM: 121012) PREDICTED: gap junctio ( 333) 428 86.5 8.1e-17 NP_002051 (OMIM: 121012) gap junction alpha-4 prot ( 333) 428 86.5 8.1e-17 NP_068773 (OMIM: 121015,601885) gap junction alpha ( 435) 422 85.5 2.1e-16 XP_011533350 (OMIM: 121015,601885) PREDICTED: gap ( 435) 422 85.5 2.1e-16 NP_065168 (OMIM: 608803,608804,613206,613480) gap ( 439) 417 84.7 3.9e-16 NP_005488 (OMIM: 608655) gap junction gamma-1 prot ( 396) 416 84.5 4.1e-16 NP_001073852 (OMIM: 608655) gap junction gamma-1 p ( 396) 416 84.5 4.1e-16 XP_005256978 (OMIM: 608655) PREDICTED: gap junctio ( 396) 416 84.5 4.1e-16 XP_005256977 (OMIM: 608655) PREDICTED: gap junctio ( 396) 416 84.5 4.1e-16 NP_005257 (OMIM: 108770,121013,612474,614049) gap ( 358) 403 82.1 1.9e-15 NP_859054 (OMIM: 108770,121013,612474,614049) gap ( 358) 403 82.1 1.9e-15 XP_016856533 (OMIM: 108770,121013,612474,614049) P ( 358) 403 82.1 1.9e-15 XP_005273008 (OMIM: 108770,121013,612474,614049) P ( 358) 403 82.1 1.9e-15 NP_115991 (OMIM: 611924) gap junction alpha-10 pro ( 543) 399 81.5 4.3e-15 NP_110399 (OMIM: 611923) gap junction alpha-9 prot ( 515) 391 80.1 1.1e-14 XP_016884897 (OMIM: 302800,304040) PREDICTED: gap ( 283) 377 77.4 3.8e-14 XP_011529209 (OMIM: 302800,304040) PREDICTED: gap ( 283) 377 77.4 3.8e-14 NP_001091111 (OMIM: 302800,304040) gap junction be ( 283) 377 77.4 3.8e-14 NP_000157 (OMIM: 302800,304040) gap junction beta- ( 283) 377 77.4 3.8e-14 NP_003995 (OMIM: 121011,124500,148210,148350,14920 ( 226) 358 74.0 3.3e-13 XP_011533351 (OMIM: 121011,124500,148210,148350,14 ( 226) 358 74.0 3.3e-13 NP_000156 (OMIM: 104100,121014,133200,164200,18610 ( 382) 358 74.1 5e-13 XP_011538981 (OMIM: 133200,605425) PREDICTED: gap ( 266) 355 73.5 5.4e-13 NP_694944 (OMIM: 133200,605425) gap junction beta- ( 266) 355 73.5 5.4e-13 NP_001103689 (OMIM: 129500,220290,304400,604418,61 ( 261) 348 72.3 1.3e-12 XP_016875848 (OMIM: 129500,220290,304400,604418,61 ( 261) 348 72.3 1.3e-12 XP_016875849 (OMIM: 129500,220290,304400,604418,61 ( 261) 348 72.3 1.3e-12 NP_001103691 (OMIM: 129500,220290,304400,604418,61 ( 261) 348 72.3 1.3e-12 XP_016875847 (OMIM: 129500,220290,304400,604418,61 ( 261) 348 72.3 1.3e-12 NP_006774 (OMIM: 129500,220290,304400,604418,61264 ( 261) 348 72.3 1.3e-12 NP_001103690 (OMIM: 129500,220290,304400,604418,61 ( 261) 348 72.3 1.3e-12 XP_016875846 (OMIM: 129500,220290,304400,604418,61 ( 261) 348 72.3 1.3e-12 NP_001005752 (OMIM: 133200,220290,603324,612644) g ( 270) 338 70.5 4.4e-12 NP_076872 (OMIM: 133200,220290,603324,612644) gap ( 270) 338 70.5 4.4e-12 NP_005259 (OMIM: 604493) gap junction beta-5 prote ( 273) 331 69.3 1.1e-11 XP_005270808 (OMIM: 604493) PREDICTED: gap junctio ( 273) 331 69.3 1.1e-11 NP_940970 (OMIM: 611921) gap junction beta-7 prote ( 223) 320 67.2 3.5e-11 XP_005248773 (OMIM: 611921) PREDICTED: gap junctio ( 223) 320 67.2 3.5e-11 NP_853516 (OMIM: 611925) gap junction gamma-3 prot ( 279) 308 65.2 1.8e-10 NP_699199 (OMIM: 611922) gap junction delta-4 prot ( 370) 300 63.8 6.1e-10 >>NP_065711 (OMIM: 607058) gap junction delta-2 protein (321 aa) initn: 2145 init1: 2145 opt: 2145 Z-score: 2070.7 bits: 391.4 E(85289): 1.3e-108 Smith-Waterman score: 2145; 100.0% identity (100.0% similar) in 321 aa overlap (1-321:1-321) 10 20 30 40 50 60 pF1KE2 MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 GCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 PESIGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 PESIGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 LRTASKSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 LRTASKSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 ECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSIYEIRNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 ECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSIYEIRNK 250 260 270 280 290 300 310 320 pF1KE2 DLPRVSVPNFGRTQSSDSAYV ::::::::::::::::::::: NP_065 DLPRVSVPNFGRTQSSDSAYV 310 320 >>XP_016877927 (OMIM: 607058) PREDICTED: gap junction de (270 aa) initn: 1833 init1: 1833 opt: 1833 Z-score: 1772.4 bits: 335.9 E(85289): 5.5e-92 Smith-Waterman score: 1833; 100.0% identity (100.0% similar) in 270 aa overlap (52-321:1-270) 30 40 50 60 70 80 pF1KE2 IGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQPGCNQACYDRAFPISHIRYWVF :::::::::::::::::::::::::::::: XP_016 MFVCNTLQPGCNQACYDRAFPISHIRYWVF 10 20 30 90 100 110 120 130 140 pF1KE2 QIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDPPESIGGPGGTGGGGSGGGKRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDPPESIGGPGGTGGGGSGGGKRE 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE2 DKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSGLRTASKSKLRRQEGISRFYII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSGLRTASKSKLRRQEGISRFYII 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE2 QVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEVECYVSRPTEKTVFLVFMFAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEVECYVSRPTEKTVFLVFMFAVS 160 170 180 190 200 210 270 280 290 300 310 320 pF1KE2 GICVVLNLAELNHLGWRKIKLAVRGAQAKRKSIYEIRNKDLPRVSVPNFGRTQSSDSAYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GICVVLNLAELNHLGWRKIKLAVRGAQAKRKSIYEIRNKDLPRVSVPNFGRTQSSDSAYV 220 230 240 250 260 270 >>NP_689343 (OMIM: 607425) gap junction delta-3 protein (294 aa) initn: 692 init1: 396 opt: 433 Z-score: 428.5 bits: 87.4 E(85289): 4e-17 Smith-Waterman score: 592; 37.8% identity (60.5% similar) in 304 aa overlap (1-303:1-239) 10 20 30 40 50 60 pF1KE2 MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQP ::::..: ::.: :: .: ..::. :.:..:::::..: :: .:..::: :::::::: NP_689 MGEWAFLGSLLDA-VQLQSPLVGRLWLVVMLIFRILVLATVGGAVFEDEQEEFVCNTLQP 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 GCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDP :: :.:::::::.:: :.:.:.:... .: . :..::.:...:. NP_689 GCRQTCYDRAFPVSHYRFWLFHILLLSAPPVLFVVYSMHRAGKE---------------- 60 70 80 90 100 130 140 150 160 170 180 pF1KE2 PESIGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSG .::. . : : :. : .: : . NP_689 -----------AGGA------EAAAQCA--PGL----------PEAQCA--------PCA 110 120 190 200 210 220 230 240 pF1KE2 LRTASKSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEV ::. :: . : :...:..: :. :: :: .:::: : . : :: . : NP_689 LRA------RRAR---RCYLLSVALRLLAELTFLGGQALLYGFRVAPHFACAGPPCPHTV 130 140 150 160 170 250 260 270 280 290 pF1KE2 ECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWR-KIKLAVRGAQAKRKSIYEIRN .:.::::::::::..:.:::. . ..:..:::.:: :. . . . : . .: .: . NP_689 DCFVSRPTEKTVFVLFYFAVGLLSALLSVAELGHLLWKGRPRAGERDNRCNR--AHEEAQ 180 190 200 210 220 230 300 310 320 pF1KE2 KDLPRVSVPNFGRTQSSDSAYV : :: NP_689 KLLPPPPPPPPPPALPSRRPGPEPCAPPAYAHPAPASLRECGSGRGKASPATGRRDLAI 240 250 260 270 280 290 >>XP_011507719 (OMIM: 116200,600897,612474) PREDICTED: g (427 aa) initn: 712 init1: 381 opt: 433 Z-score: 426.1 bits: 87.5 E(85289): 5.4e-17 Smith-Waterman score: 725; 40.6% identity (67.3% similar) in 315 aa overlap (1-314:1-264) 10 20 30 40 50 60 pF1KE2 MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQP ::.:..: .:: :..:::.:::. :::. ::::::.. ..: :. :::. ::::: :: XP_011 MGDWSFLGNILEE-VNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQP 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 GCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDP ::...:::.:::::::: ::.:::.: :::: .. ..:: ....:.: : :. XP_011 GCENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHY-VRMEEKRKS-------REA 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 PESIGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSG : .: .::.:: :: ::. :: XP_011 -EELGQQAGTNGG--------------------------------PDQGSVKK----SSG 120 130 190 200 210 220 230 pF1KE2 LRTASKSKLRRQEG-ISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKE . ..: .: :: . : :: ...:.. .:.::.::.:::::: . ::.:.:.:: . XP_011 SKGTKKFRL---EGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRILPLYRCSRWPCPNV 140 150 160 170 180 190 240 250 260 270 280 290 pF1KE2 VECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSIYEIRN :.:.::::::::.:..::..:... . ::. ::.::: . :. :.. . .. . :: . XP_011 VDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALK--RPVEQPLGEIPE 200 210 220 230 240 300 310 320 pF1KE2 KDLPRVSVPNFGRTQSSDSAYV :.: ..: .. ... XP_011 KSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLPAKPFNQFEEKISTGPL 250 260 270 280 290 300 >>NP_005258 (OMIM: 116200,600897,612474) gap junction al (433 aa) initn: 712 init1: 381 opt: 433 Z-score: 426.0 bits: 87.5 E(85289): 5.4e-17 Smith-Waterman score: 725; 40.6% identity (67.3% similar) in 315 aa overlap (1-314:1-264) 10 20 30 40 50 60 pF1KE2 MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQP ::.:..: .:: :..:::.:::. :::. ::::::.. ..: :. :::. ::::: :: NP_005 MGDWSFLGNILEE-VNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQP 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 GCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDP ::...:::.:::::::: ::.:::.: :::: .. ..:: ....:.: : :. NP_005 GCENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHY-VRMEEKRKS-------REA 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 PESIGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSG : .: .::.:: :: ::. :: NP_005 -EELGQQAGTNGG--------------------------------PDQGSVKK----SSG 120 130 190 200 210 220 230 pF1KE2 LRTASKSKLRRQEG-ISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKE . ..: .: :: . : :: ...:.. .:.::.::.:::::: . ::.:.:.:: . NP_005 SKGTKKFRL---EGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRILPLYRCSRWPCPNV 140 150 160 170 180 190 240 250 260 270 280 290 pF1KE2 VECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSIYEIRN :.:.::::::::.:..::..:... . ::. ::.::: . :. :.. . .. . :: . NP_005 VDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALK--RPVEQPLGEIPE 200 210 220 230 240 300 310 320 pF1KE2 KDLPRVSVPNFGRTQSSDSAYV :.: ..: .. ... NP_005 KSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLPAKPFNQFEEKISTGPL 250 260 270 280 290 300 >>XP_011507718 (OMIM: 116200,600897,612474) PREDICTED: g (433 aa) initn: 712 init1: 381 opt: 433 Z-score: 426.0 bits: 87.5 E(85289): 5.4e-17 Smith-Waterman score: 725; 40.6% identity (67.3% similar) in 315 aa overlap (1-314:1-264) 10 20 30 40 50 60 pF1KE2 MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQP ::.:..: .:: :..:::.:::. :::. ::::::.. ..: :. :::. ::::: :: XP_011 MGDWSFLGNILEE-VNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQP 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 GCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDP ::...:::.:::::::: ::.:::.: :::: .. ..:: ....:.: : :. XP_011 GCENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHY-VRMEEKRKS-------REA 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 PESIGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSG : .: .::.:: :: ::. :: XP_011 -EELGQQAGTNGG--------------------------------PDQGSVKK----SSG 120 130 190 200 210 220 230 pF1KE2 LRTASKSKLRRQEG-ISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKE . ..: .: :: . : :: ...:.. .:.::.::.:::::: . ::.:.:.:: . XP_011 SKGTKKFRL---EGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRILPLYRCSRWPCPNV 140 150 160 170 180 190 240 250 260 270 280 290 pF1KE2 VECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSIYEIRN :.:.::::::::.:..::..:... . ::. ::.::: . :. :.. . .. . :: . XP_011 VDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALK--RPVEQPLGEIPE 200 210 220 230 240 300 310 320 pF1KE2 KDLPRVSVPNFGRTQSSDSAYV :.: ..: .. ... XP_011 KSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLPAKPFNQFEEKISTGPL 250 260 270 280 290 300 >>XP_016856532 (OMIM: 121012) PREDICTED: gap junction al (333 aa) initn: 694 init1: 381 opt: 428 Z-score: 422.9 bits: 86.5 E(85289): 8.1e-17 Smith-Waterman score: 624; 38.3% identity (65.5% similar) in 290 aa overlap (1-290:1-246) 10 20 30 40 50 60 pF1KE2 MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQP ::.: .::.::. ::.:::..:.: :::. ::::::....::.:. :::. : ::: :: XP_016 MGDWGFLEKLLDQ-VQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQP 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 GCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDP ::...:::.:::::::::::.:...: ::.: .. . .. : .::.: : . XP_016 GCTNVCYDQAFPISHIRYWVLQFLFVSTPTLVYLGHVIYLS--RREER-------LRQKE 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 PESIGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSG : . :. .: ... :.. : .. XP_016 GELRALPA------------KDPQVERALAAVERQMAK---------------------- 120 130 190 200 210 220 230 240 pF1KE2 LRTASKSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEV . .: ..:: . .. :. .:. ...:: ::: ::. :::... .. :.: :: : XP_016 ISVAEDGRLRIRGALMGTYVASVLCKSVLEAGFLYGQWRLYGWTMEPVFVCQRAPCPYLV 140 150 160 170 180 190 250 260 270 280 290 300 pF1KE2 ECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSIYEIRNK .:.::::::::.:..::..:. : .:::: :: :: : .. ..:. :.. XP_016 DCFVSRPTEKTIFIIFMLVVGLISLVLNLLELVHLLCRCLSRGMRARQGQDAPPTQGTSS 200 210 220 230 240 250 310 320 pF1KE2 DLPRVSVPNFGRTQSSDSAYV XP_016 DPYTDQVFFYLPVGQGPSSPPCPTYNGLSSSEQNWANLTTEERLASSRPPLFLDPPPQNG 260 270 280 290 300 310 >>XP_005270807 (OMIM: 121012) PREDICTED: gap junction al (333 aa) initn: 694 init1: 381 opt: 428 Z-score: 422.9 bits: 86.5 E(85289): 8.1e-17 Smith-Waterman score: 624; 38.3% identity (65.5% similar) in 290 aa overlap (1-290:1-246) 10 20 30 40 50 60 pF1KE2 MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQP ::.: .::.::. ::.:::..:.: :::. ::::::....::.:. :::. : ::: :: XP_005 MGDWGFLEKLLDQ-VQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQP 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 GCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDP ::...:::.:::::::::::.:...: ::.: .. . .. : .::.: : . XP_005 GCTNVCYDQAFPISHIRYWVLQFLFVSTPTLVYLGHVIYLS--RREER-------LRQKE 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 PESIGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSG : . :. .: ... :.. : .. XP_005 GELRALPA------------KDPQVERALAAVERQMAK---------------------- 120 130 190 200 210 220 230 240 pF1KE2 LRTASKSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEV . .: ..:: . .. :. .:. ...:: ::: ::. :::... .. :.: :: : XP_005 ISVAEDGRLRIRGALMGTYVASVLCKSVLEAGFLYGQWRLYGWTMEPVFVCQRAPCPYLV 140 150 160 170 180 190 250 260 270 280 290 300 pF1KE2 ECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSIYEIRNK .:.::::::::.:..::..:. : .:::: :: :: : .. ..:. :.. XP_005 DCFVSRPTEKTIFIIFMLVVGLISLVLNLLELVHLLCRCLSRGMRARQGQDAPPTQGTSS 200 210 220 230 240 250 310 320 pF1KE2 DLPRVSVPNFGRTQSSDSAYV XP_005 DPYTDQVFFYLPVGQGPSSPPCPTYNGLSSSEQNWANLTTEERLASSRPPLFLDPPPQNG 260 270 280 290 300 310 >>NP_002051 (OMIM: 121012) gap junction alpha-4 protein (333 aa) initn: 694 init1: 381 opt: 428 Z-score: 422.9 bits: 86.5 E(85289): 8.1e-17 Smith-Waterman score: 624; 38.3% identity (65.5% similar) in 290 aa overlap (1-290:1-246) 10 20 30 40 50 60 pF1KE2 MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQP ::.: .::.::. ::.:::..:.: :::. ::::::....::.:. :::. : ::: :: NP_002 MGDWGFLEKLLDQ-VQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQP 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 GCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDP ::...:::.:::::::::::.:...: ::.: .. . .. : .::.: : . NP_002 GCTNVCYDQAFPISHIRYWVLQFLFVSTPTLVYLGHVIYLS--RREER-------LRQKE 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 PESIGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSG : . :. .: ... :.. : .. NP_002 GELRALPA------------KDPQVERALAAVERQMAK---------------------- 120 130 190 200 210 220 230 240 pF1KE2 LRTASKSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEV . .: ..:: . .. :. .:. ...:: ::: ::. :::... .. :.: :: : NP_002 ISVAEDGRLRIRGALMGTYVASVLCKSVLEAGFLYGQWRLYGWTMEPVFVCQRAPCPYLV 140 150 160 170 180 190 250 260 270 280 290 300 pF1KE2 ECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSIYEIRNK .:.::::::::.:..::..:. : .:::: :: :: : .. ..:. :.. NP_002 DCFVSRPTEKTIFIIFMLVVGLISLVLNLLELVHLLCRCLSRGMRARQGQDAPPTQGTSS 200 210 220 230 240 250 310 320 pF1KE2 DLPRVSVPNFGRTQSSDSAYV NP_002 DPYTDQVFFYLPVGQGPSSPPCPTYNGLSSSEQNWANLTTEERLASSRPPLFLDPPPQNG 260 270 280 290 300 310 >>NP_068773 (OMIM: 121015,601885) gap junction alpha-3 p (435 aa) initn: 679 init1: 371 opt: 422 Z-score: 415.5 bits: 85.5 E(85289): 2.1e-16 Smith-Waterman score: 712; 38.3% identity (65.3% similar) in 311 aa overlap (1-308:1-261) 10 20 30 40 50 60 pF1KE2 MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQP ::.:..: :::: : :.:::.::.. :::. :::::... ..: :. :::. :.::: :: NP_068 MGDWSFLGRLLENA-QEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQP 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 GCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDP ::...::::::::::::.:..:::.: ::.: .. . .: ....:.. .:. NP_068 GCENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHI-VRMEEKKK-------EREE 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 PESIGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSG :.. :::. . :: : .::. NP_068 EEQL--------------KRESP----------------SPKEPPQD---------NPSS 120 130 190 200 210 220 230 240 pF1KE2 LRTASKSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEV .....: .. : :.....:.. .:.::..:::::::: . ::.:.:.:: . : NP_068 --RDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELKPLYRCDRWPCPNTV 140 150 160 170 180 190 250 260 270 280 290 pF1KE2 ECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVR---GAQAKRKSIYEI .:..:::::::.:..::.::. ..::. :. ::::.:.: .: : .:.. . NP_068 DCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTSRLGPDASEAPLGTA 200 210 220 230 240 250 300 310 320 pF1KE2 RNKDLPRVSVPNFGRTQSSDSAYV :: : : NP_068 DPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAADFKLLALTEARGKGQ 260 270 280 290 300 310 321 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 19:59:33 2016 done: Mon Nov 7 19:59:34 2016 Total Scan time: 7.820 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]