FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2259, 502 aa 1>>>pF1KE2259 502 - 502 aa - 502 aa Library: /omim/omim.rfq.tfa 65089639 residues in 91964 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1432+/-0.000337; mu= 19.2001+/- 0.021 mean_var=71.3447+/-14.324, 0's: 0 Z-trim(114.9): 178 B-trim: 0 in 0/54 Lambda= 0.151842 statistics sampled from 25756 (25937) to 25756 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.653), E-opt: 0.2 (0.282), width: 16 Scan time: 4.400 The best scores are: opt bits E(91964) NP_000737 (OMIM: 118511,612001) neuronal acetylcho ( 502) 3488 773.5 0 NP_001177384 (OMIM: 118511,612001) neuronal acetyl ( 531) 3360 745.5 9.6e-215 XP_011519478 (OMIM: 118511,612001) neuronal acetyl ( 486) 3060 679.7 5.5e-195 XP_011519479 (OMIM: 118511,612001) neuronal acetyl ( 401) 2694 599.5 6.4e-171 XP_016877372 (OMIM: 118511,612001) neuronal acetyl ( 440) 2690 598.6 1.3e-170 XP_016877371 (OMIM: 118511,612001) neuronal acetyl ( 441) 2690 598.6 1.3e-170 NP_647536 (OMIM: 609756) CHRNA7-FAM7A fusion prote ( 412) 2685 597.5 2.6e-170 XP_011520455 (OMIM: 609756) CHRNA7-FAM7A fusion pr ( 412) 2685 597.5 2.6e-170 XP_016877373 (OMIM: 118511,612001) neuronal acetyl ( 321) 2206 492.5 8.2e-139 XP_005254807 (OMIM: 609756) CHRNA7-FAM7A fusion pr ( 321) 2206 492.5 8.2e-139 NP_683709 (OMIM: 609756) CHRNA7-FAM7A fusion prote ( 321) 2206 492.5 8.2e-139 XP_011519480 (OMIM: 118511,612001) neuronal acetyl ( 380) 2026 453.1 6.9e-127 NP_000733 (OMIM: 118502,610353) neuronal acetylcho ( 529) 1232 279.3 2.1e-74 XP_011520457 (OMIM: 609756) CHRNA7-FAM7A fusion pr ( 290) 1223 277.1 5e-74 NP_000734 (OMIM: 118503,612052) neuronal acetylcho ( 505) 1220 276.6 1.2e-73 NP_001269384 (OMIM: 118502,610353) neuronal acetyl ( 514) 1132 257.4 7.9e-68 NP_001160166 (OMIM: 118503,612052) neuronal acetyl ( 489) 1131 257.1 8.8e-68 NP_000735 (OMIM: 118504,188890,600513) neuronal ac ( 627) 1118 254.4 7.7e-67 XP_006720445 (OMIM: 118503,612052) neuronal acetyl ( 438) 1091 248.3 3.5e-65 NP_065135 (OMIM: 606372) neuronal acetylcholine re ( 450) 1074 244.6 4.8e-64 NP_060051 (OMIM: 605116) neuronal acetylcholine re ( 479) 1070 243.8 9.2e-64 XP_011519488 (OMIM: 118509) neuronal acetylcholine ( 495) 1055 240.5 9.2e-63 XP_011519489 (OMIM: 118509) neuronal acetylcholine ( 495) 1055 240.5 9.2e-63 XP_016877378 (OMIM: 118509) neuronal acetylcholine ( 449) 1052 239.8 1.3e-62 XP_016877377 (OMIM: 118509) neuronal acetylcholine ( 462) 1052 239.8 1.4e-62 XP_016877376 (OMIM: 118509) neuronal acetylcholine ( 463) 1052 239.8 1.4e-62 NP_000741 (OMIM: 118509) neuronal acetylcholine re ( 498) 1052 239.8 1.5e-62 NP_004189 (OMIM: 606888) neuronal acetylcholine re ( 494) 1049 239.2 2.3e-62 XP_016877374 (OMIM: 118509) neuronal acetylcholine ( 468) 1046 238.5 3.4e-62 XP_016877375 (OMIM: 118509) neuronal acetylcholine ( 468) 1046 238.5 3.4e-62 NP_000739 (OMIM: 118507,605375) neuronal acetylcho ( 502) 1019 232.6 2.2e-60 XP_016858746 (OMIM: 100690,253290,601462,608930) a ( 464) 993 226.9 1.1e-58 NP_000070 (OMIM: 100690,253290,601462,608930) acet ( 457) 991 226.5 1.4e-58 NP_000740 (OMIM: 118508) neuronal acetylcholine re ( 458) 949 217.3 8.4e-56 XP_011519493 (OMIM: 118509) neuronal acetylcholine ( 424) 948 217.0 9.2e-56 XP_011519492 (OMIM: 118509) neuronal acetylcholine ( 424) 948 217.0 9.2e-56 NP_000736 (OMIM: 118505,612052) neuronal acetylcho ( 468) 946 216.6 1.4e-55 NP_001334635 (OMIM: 118502,610353) neuronal acetyl ( 370) 884 202.9 1.4e-51 NP_001334634 (OMIM: 118502,610353) neuronal acetyl ( 370) 884 202.9 1.4e-51 NP_001186208 (OMIM: 606888) neuronal acetylcholine ( 479) 870 200.0 1.4e-50 NP_001034612 (OMIM: 100690,253290,601462,608930) a ( 482) 845 194.5 6.3e-49 XP_016858745 (OMIM: 100690,253290,601462,608930) a ( 489) 845 194.5 6.4e-49 NP_001334646 (OMIM: 118508) neuronal acetylcholine ( 384) 828 190.7 7e-48 XP_011526826 (OMIM: 118504,188890,600513) neuronal ( 556) 779 180.1 1.6e-44 NP_001334637 (OMIM: 118502,610353) neuronal acetyl ( 331) 736 170.5 7.3e-42 NP_001334636 (OMIM: 118502,610353) neuronal acetyl ( 331) 736 170.5 7.3e-42 XP_011542691 (OMIM: 118502,610353) neuronal acetyl ( 331) 736 170.5 7.3e-42 NP_001155244 (OMIM: 182139) 5-hydroxytryptamine re ( 463) 714 165.8 2.7e-40 NP_000860 (OMIM: 182139) 5-hydroxytryptamine recep ( 478) 714 165.8 2.7e-40 XP_024307590 (OMIM: 118504,188890,600513) neuronal ( 451) 626 146.5 1.7e-34 >>NP_000737 (OMIM: 118511,612001) neuronal acetylcholine (502 aa) initn: 3488 init1: 3488 opt: 3488 Z-score: 4128.8 bits: 773.5 E(91964): 0 Smith-Waterman score: 3488; 100.0% identity (100.0% similar) in 502 aa overlap (1-502:1-502) 10 20 30 40 50 60 pF1KE2 MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 QRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 QRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI 430 440 450 460 470 480 490 500 pF1KE2 ICTIGILMSAPNFVEAVSKDFA :::::::::::::::::::::: NP_000 ICTIGILMSAPNFVEAVSKDFA 490 500 >>NP_001177384 (OMIM: 118511,612001) neuronal acetylchol (531 aa) initn: 3474 init1: 3360 opt: 3360 Z-score: 3976.9 bits: 745.5 E(91964): 9.6e-215 Smith-Waterman score: 3420; 94.5% identity (94.5% similar) in 531 aa overlap (1-502:1-531) 10 20 30 pF1KE2 MRCSPGGVWLALAASLLH-----------------------------VSLQGEFQRKLYK :::::::::::::::::: ::::::::::::: NP_001 MRCSPGGVWLALAASLLHGKATASPPSTPPWDPGHIPGASVRPAPGPVSLQGEFQRKLYK 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE2 ELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNV 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE2 SEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCY 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE2 IDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYE 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE2 CCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLS 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE2 LTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWT 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE2 RVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRG 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE2 LDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQD 430 440 450 460 470 480 460 470 480 490 500 pF1KE2 ESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA 490 500 510 520 530 >>XP_011519478 (OMIM: 118511,612001) neuronal acetylchol (486 aa) initn: 3060 init1: 3060 opt: 3060 Z-score: 3622.2 bits: 679.7 E(91964): 5.5e-195 Smith-Waterman score: 3060; 100.0% identity (100.0% similar) in 437 aa overlap (66-502:50-486) 40 50 60 70 80 90 pF1KE2 NYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYP :::::::::::::::::::::::::::::: XP_011 AGQGLIGEDTAPADLLLPESHRTSLRRGKGDEKNQVLTTNIWLQMSWTDHYLQWNVSEYP 20 30 40 50 60 70 100 110 120 130 140 150 pF1KE2 GVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVR 80 90 100 110 120 130 160 170 180 190 200 210 pF1KE2 WFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKE 140 150 160 170 180 190 220 230 240 250 260 270 pF1KE2 PYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVF 200 210 220 230 240 250 280 290 300 310 320 330 pF1KE2 MLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVIL 260 270 280 290 300 310 340 350 360 370 380 390 pF1KE2 LNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGV 320 330 340 350 360 370 400 410 420 430 440 450 pF1KE2 HCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEA 380 390 400 410 420 430 460 470 480 490 500 pF1KE2 VCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA 440 450 460 470 480 >>XP_011519479 (OMIM: 118511,612001) neuronal acetylchol (401 aa) initn: 2694 init1: 2694 opt: 2694 Z-score: 3190.1 bits: 599.5 E(91964): 6.4e-171 Smith-Waterman score: 2694; 99.5% identity (99.7% similar) in 389 aa overlap (114-502:13-401) 90 100 110 120 130 140 pF1KE2 DHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPP : .::::::::::::::::::::::::::: XP_011 MKNIQKSLSHKSLSHSADERFDATFHTNVLVNSSGHCQYLPP 10 20 30 40 150 160 170 180 190 200 pF1KE2 GIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPG 50 60 70 80 90 100 210 220 230 240 250 260 pF1KE2 KRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKIS 110 120 130 140 150 160 270 280 290 300 310 320 pF1KE2 LGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPD 170 180 190 200 210 220 330 340 350 360 370 380 pF1KE2 GGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGN 230 240 250 260 270 280 390 400 410 420 430 440 pF1KE2 LLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYI 290 300 310 320 330 340 450 460 470 480 490 500 pF1KE2 ANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA 350 360 370 380 390 400 >>XP_016877372 (OMIM: 118511,612001) neuronal acetylchol (440 aa) initn: 2690 init1: 2690 opt: 2690 Z-score: 3184.8 bits: 598.6 E(91964): 1.3e-170 Smith-Waterman score: 2690; 100.0% identity (100.0% similar) in 386 aa overlap (117-502:55-440) 90 100 110 120 130 140 pF1KE2 LQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIF :::::::::::::::::::::::::::::: XP_016 GCTAGAHSLDPHPRLCSLLCIGEFCGRDGCSADERFDATFHTNVLVNSSGHCQYLPPGIF 30 40 50 60 70 80 150 160 170 180 190 200 pF1KE2 KSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRS 90 100 110 120 130 140 210 220 230 240 250 260 pF1KE2 ERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGI 150 160 170 180 190 200 270 280 290 300 310 320 pF1KE2 TVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGK 210 220 230 240 250 260 330 340 350 360 370 380 pF1KE2 MPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLY 270 280 290 300 310 320 390 400 410 420 430 440 pF1KE2 IGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANR 330 340 350 360 370 380 450 460 470 480 490 500 pF1KE2 FRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA 390 400 410 420 430 440 >>XP_016877371 (OMIM: 118511,612001) neuronal acetylchol (441 aa) initn: 2690 init1: 2690 opt: 2690 Z-score: 3184.8 bits: 598.6 E(91964): 1.3e-170 Smith-Waterman score: 2690; 100.0% identity (100.0% similar) in 386 aa overlap (117-502:56-441) 90 100 110 120 130 140 pF1KE2 LQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIF :::::::::::::::::::::::::::::: XP_016 GCTAGAHSLDPHPRLCSLLCIGEFCGRDGCSADERFDATFHTNVLVNSSGHCQYLPPGIF 30 40 50 60 70 80 150 160 170 180 190 200 pF1KE2 KSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRS 90 100 110 120 130 140 210 220 230 240 250 260 pF1KE2 ERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGI 150 160 170 180 190 200 270 280 290 300 310 320 pF1KE2 TVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGK 210 220 230 240 250 260 330 340 350 360 370 380 pF1KE2 MPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLY 270 280 290 300 310 320 390 400 410 420 430 440 pF1KE2 IGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANR 330 340 350 360 370 380 450 460 470 480 490 500 pF1KE2 FRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA 390 400 410 420 430 440 >>NP_647536 (OMIM: 609756) CHRNA7-FAM7A fusion protein i (412 aa) initn: 2685 init1: 2685 opt: 2685 Z-score: 3179.3 bits: 597.5 E(91964): 2.6e-170 Smith-Waterman score: 2685; 100.0% identity (100.0% similar) in 385 aa overlap (118-502:28-412) 90 100 110 120 130 140 pF1KE2 QWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFK :::::::::::::::::::::::::::::: NP_647 MQKYCIYQHFQFQLLIQHLWIAANCDIADERFDATFHTNVLVNSSGHCQYLPPGIFK 10 20 30 40 50 150 160 170 180 190 200 pF1KE2 SSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_647 SSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSE 60 70 80 90 100 110 210 220 230 240 250 260 pF1KE2 RFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_647 RFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGIT 120 130 140 150 160 170 270 280 290 300 310 320 pF1KE2 VLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_647 VLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKM 180 190 200 210 220 230 330 340 350 360 370 380 pF1KE2 PKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_647 PKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYI 240 250 260 270 280 290 390 400 410 420 430 440 pF1KE2 GFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_647 GFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRF 300 310 320 330 340 350 450 460 470 480 490 500 pF1KE2 RCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_647 RCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA 360 370 380 390 400 410 >>XP_011520455 (OMIM: 609756) CHRNA7-FAM7A fusion protei (412 aa) initn: 2685 init1: 2685 opt: 2685 Z-score: 3179.3 bits: 597.5 E(91964): 2.6e-170 Smith-Waterman score: 2685; 100.0% identity (100.0% similar) in 385 aa overlap (118-502:28-412) 90 100 110 120 130 140 pF1KE2 QWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFK :::::::::::::::::::::::::::::: XP_011 MQKYCIYQHFQFQLLIQHLWIAANCDIADERFDATFHTNVLVNSSGHCQYLPPGIFK 10 20 30 40 50 150 160 170 180 190 200 pF1KE2 SSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSE 60 70 80 90 100 110 210 220 230 240 250 260 pF1KE2 RFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGIT 120 130 140 150 160 170 270 280 290 300 310 320 pF1KE2 VLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKM 180 190 200 210 220 230 330 340 350 360 370 380 pF1KE2 PKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYI 240 250 260 270 280 290 390 400 410 420 430 440 pF1KE2 GFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRF 300 310 320 330 340 350 450 460 470 480 490 500 pF1KE2 RCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA 360 370 380 390 400 410 >>XP_016877373 (OMIM: 118511,612001) neuronal acetylchol (321 aa) initn: 2206 init1: 2206 opt: 2206 Z-score: 2613.7 bits: 492.5 E(91964): 8.2e-139 Smith-Waterman score: 2206; 100.0% identity (100.0% similar) in 321 aa overlap (182-502:1-321) 160 170 180 190 200 210 pF1KE2 IDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYE :::::::::::::::::::::::::::::: XP_016 MQEADISGYIPNGEWDLVGIPGKRSERFYE 10 20 30 220 230 240 250 260 270 pF1KE2 CCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLS 40 50 60 70 80 90 280 290 300 310 320 330 pF1KE2 LTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWT 100 110 120 130 140 150 340 350 360 370 380 390 pF1KE2 RVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRG 160 170 180 190 200 210 400 410 420 430 440 450 pF1KE2 LDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQD 220 230 240 250 260 270 460 470 480 490 500 pF1KE2 ESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA 280 290 300 310 320 >>XP_005254807 (OMIM: 609756) CHRNA7-FAM7A fusion protei (321 aa) initn: 2206 init1: 2206 opt: 2206 Z-score: 2613.7 bits: 492.5 E(91964): 8.2e-139 Smith-Waterman score: 2206; 100.0% identity (100.0% similar) in 321 aa overlap (182-502:1-321) 160 170 180 190 200 210 pF1KE2 IDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYE :::::::::::::::::::::::::::::: XP_005 MQEADISGYIPNGEWDLVGIPGKRSERFYE 10 20 30 220 230 240 250 260 270 pF1KE2 CCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLS 40 50 60 70 80 90 280 290 300 310 320 330 pF1KE2 LTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWT 100 110 120 130 140 150 340 350 360 370 380 390 pF1KE2 RVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRG 160 170 180 190 200 210 400 410 420 430 440 450 pF1KE2 LDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQD 220 230 240 250 260 270 460 470 480 490 500 pF1KE2 ESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA 280 290 300 310 320 502 residues in 1 query sequences 65089639 residues in 91964 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Oct 2 18:31:43 2018 done: Tue Oct 2 18:31:44 2018 Total Scan time: 4.400 Total Display time: 0.110 Function used was FASTA [36.3.4 Apr, 2011]