Result of FASTA (omim) for pF1KB8480
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB8480, 854 aa
  1>>>pF1KB8480 854 - 854 aa - 854 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 9.6881+/-0.00045; mu= 1.0471+/- 0.028
 mean_var=265.8997+/-52.835, 0's: 0 Z-trim(118.7): 13  B-trim: 1122 in 1/54
 Lambda= 0.078653
 statistics sampled from 31846 (31859) to 31846 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.694), E-opt: 0.2 (0.374), width:  16
 Scan time: 12.710

The best scores are:                                      opt bits E(85289)
NP_001017963 (OMIM: 140571) heat shock protein HSP ( 854) 5588 648.3 4.4e-185
XP_011535020 (OMIM: 140571) PREDICTED: heat shock  ( 853) 5571 646.3 1.7e-184
NP_005339 (OMIM: 140571) heat shock protein HSP 90 ( 732) 4718 549.5  2e-155
NP_001258899 (OMIM: 140572) heat shock protein HSP ( 724) 4122 481.9 4.6e-135
NP_031381 (OMIM: 140572) heat shock protein HSP 90 ( 724) 4122 481.9 4.6e-135
NP_001258898 (OMIM: 140572) heat shock protein HSP ( 724) 4122 481.9 4.6e-135
NP_001258900 (OMIM: 140572) heat shock protein HSP ( 676) 3462 407.0 1.5e-112
NP_001258901 (OMIM: 140572) heat shock protein HSP ( 714) 3424 402.7 3.2e-111
NP_003290 (OMIM: 191175) endoplasmin precursor [Ho ( 803) 1463 180.2 3.4e-44
XP_011520647 (OMIM: 606219) PREDICTED: heat shock  ( 564)  626 85.1   1e-15
NP_001258978 (OMIM: 606219) heat shock protein 75  ( 651)  626 85.1 1.1e-15
NP_057376 (OMIM: 606219) heat shock protein 75 kDa ( 704)  626 85.2 1.2e-15
XP_016878340 (OMIM: 606219) PREDICTED: heat shock  ( 405)  590 80.9 1.3e-14


>>NP_001017963 (OMIM: 140571) heat shock protein HSP 90-  (854 aa)
 initn: 5588 init1: 5588 opt: 5588  Z-score: 3443.8  bits: 648.3 E(85289): 4.4e-185
Smith-Waterman score: 5588; 99.9% identity (100.0% similar) in 854 aa overlap (1-854:1-854)

               10        20        30        40        50        60
pF1KB8 MPPCSGGDGSTPPGPSLRDRDCPAQSAEYPRDRLDPRPGSPSEASSPPFLRSRAPVNWYQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPPCSGGDGSTPPGPSLRDRDCPAQSAEYPRDRLDPRPGSPSEASSPPFLRSRAPVNWYQ
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 EKAQVFLWHLLVSGSTTLLCLWKQPFHVSAFPVTASLAFRQSQGAGQHLYKDLQPFILLR
       ::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKAQVFLWHLMVSGSTTLLCLWKQPFHVSAFPVTASLAFRQSQGAGQHLYKDLQPFILLR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 LLMPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLMPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 IRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAF
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 MEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB8 PMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEK
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB8 EDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWT
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB8 RNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB8 NNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVK
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB8 KCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLK
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB8 DYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEG
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB8 KTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCC
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB8 IVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKS
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB8 VKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPP
              790       800       810       820       830       840

              850    
pF1KB8 LEGDDDTSRMEEVD
       ::::::::::::::
NP_001 LEGDDDTSRMEEVD
              850    

>>XP_011535020 (OMIM: 140571) PREDICTED: heat shock prot  (853 aa)
 initn: 5569 init1: 5198 opt: 5571  Z-score: 3433.4  bits: 646.3 E(85289): 1.7e-184
Smith-Waterman score: 5571; 99.8% identity (99.9% similar) in 854 aa overlap (1-854:1-853)

               10        20        30        40        50        60
pF1KB8 MPPCSGGDGSTPPGPSLRDRDCPAQSAEYPRDRLDPRPGSPSEASSPPFLRSRAPVNWYQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::
XP_011 MPPCSGGDGSTPPGPSLRDRDCPAQSAEYPRDRLDPRPGSPSEASSPPFLR-RAPVNWYQ
               10        20        30        40        50          

               70        80        90       100       110       120
pF1KB8 EKAQVFLWHLLVSGSTTLLCLWKQPFHVSAFPVTASLAFRQSQGAGQHLYKDLQPFILLR
       ::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKAQVFLWHLMVSGSTTLLCLWKQPFHVSAFPVTASLAFRQSQGAGQHLYKDLQPFILLR
      60        70        80        90       100       110         

              130       140       150       160       170       180
pF1KB8 LLMPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLMPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDK
     120       130       140       150       160       170         

              190       200       210       220       230       240
pF1KB8 IRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAF
     180       190       200       210       220       230         

              250       260       270       280       290       300
pF1KB8 MEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGE
     240       250       260       270       280       290         

              310       320       330       340       350       360
pF1KB8 PMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEK
     300       310       320       330       340       350         

              370       380       390       400       410       420
pF1KB8 EDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWT
     360       370       380       390       400       410         

              430       440       450       460       470       480
pF1KB8 RNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKK
     420       430       440       450       460       470         

              490       500       510       520       530       540
pF1KB8 NNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVK
     480       490       500       510       520       530         

              550       560       570       580       590       600
pF1KB8 KCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLK
     540       550       560       570       580       590         

              610       620       630       640       650       660
pF1KB8 DYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEG
     600       610       620       630       640       650         

              670       680       690       700       710       720
pF1KB8 KTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCC
     660       670       680       690       700       710         

              730       740       750       760       770       780
pF1KB8 IVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKS
     720       730       740       750       760       770         

              790       800       810       820       830       840
pF1KB8 VKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPP
     780       790       800       810       820       830         

              850    
pF1KB8 LEGDDDTSRMEEVD
       ::::::::::::::
XP_011 LEGDDDTSRMEEVD
     840       850   

>>NP_005339 (OMIM: 140571) heat shock protein HSP 90-alp  (732 aa)
 initn: 4718 init1: 4718 opt: 4718  Z-score: 2911.2  bits: 549.5 E(85289): 2e-155
Smith-Waterman score: 4718; 100.0% identity (100.0% similar) in 732 aa overlap (123-854:1-732)

            100       110       120       130       140       150  
pF1KB8 VTASLAFRQSQGAGQHLYKDLQPFILLRLLMPEETQTQDQPMEEEEVETFAFQAEIAQLM
                                     ::::::::::::::::::::::::::::::
NP_005                               MPEETQTQDQPMEEEEVETFAFQAEIAQLM
                                             10        20        30

            160       170       180       190       200       210  
pF1KB8 SLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLT
               40        50        60        70        80        90

            220       230       240       250       260       270  
pF1KB8 IVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 IVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTV
              100       110       120       130       140       150

            280       290       300       310       320       330  
pF1KB8 ITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKH
              160       170       180       190       200       210

            340       350       360       370       380       390  
pF1KB8 SQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKK
              220       230       240       250       260       270

            400       410       420       430       440       450  
pF1KB8 DGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFS
              280       290       300       310       320       330

            460       470       480       490       500       510  
pF1KB8 VEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVD
              340       350       360       370       380       390

            520       530       540       550       560       570  
pF1KB8 SEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIH
              400       410       420       430       440       450

            580       590       600       610       620       630  
pF1KB8 EDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVER
              460       470       480       490       500       510

            640       650       660       670       680       690  
pF1KB8 LRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFEN
              520       530       540       550       560       570

            700       710       720       730       740       750  
pF1KB8 LCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAA
              580       590       600       610       620       630

            760       770       780       790       800       810  
pF1KB8 KKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYR
              640       650       660       670       680       690

            820       830       840       850    
pF1KB8 MIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
       ::::::::::::::::::::::::::::::::::::::::::
NP_005 MIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
              700       710       720       730  

>>NP_001258899 (OMIM: 140572) heat shock protein HSP 90-  (724 aa)
 initn: 2811 init1: 2811 opt: 4122  Z-score: 2545.8  bits: 481.9 E(85289): 4.6e-135
Smith-Waterman score: 4122; 85.8% identity (96.0% similar) in 732 aa overlap (123-854:1-724)

            100       110       120       130       140       150  
pF1KB8 VTASLAFRQSQGAGQHLYKDLQPFILLRLLMPEETQTQDQPMEEEEVETFAFQAEIAQLM
                                     ::::..       :::::::::::::::::
NP_001                               MPEEVH-----HGEEEVETFAFQAEIAQLM
                                                  10        20     

            160       170       180       190       200       210  
pF1KB8 SLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLT
       :::::::::::::::::::::.::::::::::::::::::::::::.:..::: :.::::
NP_001 SLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLT
          30        40        50        60        70        80     

            220       230       240       250       260       270  
pF1KB8 IVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTV
       .:::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
NP_001 LVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVV
          90       100       110       120       130       140     

            280       290       300       310       320       330  
pF1KB8 ITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKH
       :::::::::::::::::::::::.: :::.::::::::::::::::::::::.::.::::
NP_001 ITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKH
         150       160       170       180       190       200     

            340       350       360       370       380       390  
pF1KB8 SQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKK
       ::::::::::..::::.::.:::::::..    :::.:.:..:.::.:::::::::... 
NP_001 SQFIGYPITLYLEKEREKEISDDEAEEEKG---EKEEEDKDDEEKPKIEDVGSDEEDDSG
         210       220       230          240       250       260  

            400       410       420       430       440       450  
pF1KB8 DGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFS
          ::: ::::::::::::::::::::::::::::.::::::::::::::::::::::::
NP_001 KDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFS
            270       280       290       300       310       320  

            460       470       480       490       500       510  
pF1KB8 VEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVD
       ::::::::::::.:::::::::::.:::::::::::::::::.:.:::::::::::::::
NP_001 VEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVD
            330       340       350       360       370       380  

            520       530       540       550       560       570  
pF1KB8 SEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIH
       :::::::::::::::::::::::::.::::::::.:::::::::::::: ::::.:::::
NP_001 SEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIH
            390       400       410       420       430       440  

            580       590       600       610       620       630  
pF1KB8 EDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVER
       ::: ::..:::::::.:: :::::.::..: .::::.:: :::::::.:.::::::::::
NP_001 EDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVER
            450       460       470       480       490       500  

            640       650       660       670       680       690  
pF1KB8 LRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFEN
       .::.:.::.:: ::::::::::::::.::.::::::::::::::::::::.::.:.::::
NP_001 VRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFEN
            510       520       530       540       550       560  

            700       710       720       730       740       750  
pF1KB8 LCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAA
       :::.::.::.::::::..:::::.:::::::::::::::::::::::::::::::::: :
NP_001 LCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMA
            570       580       590       600       610       620  

            760       770       780       790       800       810  
pF1KB8 KKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYR
       :::::::::: :.::::::::::::::.:::::.::.:::::::::::::::::.:::::
NP_001 KKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYR
            630       640       650       660       670       680  

            820       830       840       850    
pF1KB8 MIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
       :::::::::::. .:.. .::: .:.::::::.:.:::::::
NP_001 MIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD
            690       700       710       720    

>>NP_031381 (OMIM: 140572) heat shock protein HSP 90-bet  (724 aa)
 initn: 2811 init1: 2811 opt: 4122  Z-score: 2545.8  bits: 481.9 E(85289): 4.6e-135
Smith-Waterman score: 4122; 85.8% identity (96.0% similar) in 732 aa overlap (123-854:1-724)

            100       110       120       130       140       150  
pF1KB8 VTASLAFRQSQGAGQHLYKDLQPFILLRLLMPEETQTQDQPMEEEEVETFAFQAEIAQLM
                                     ::::..       :::::::::::::::::
NP_031                               MPEEVH-----HGEEEVETFAFQAEIAQLM
                                                  10        20     

            160       170       180       190       200       210  
pF1KB8 SLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLT
       :::::::::::::::::::::.::::::::::::::::::::::::.:..::: :.::::
NP_031 SLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLT
          30        40        50        60        70        80     

            220       230       240       250       260       270  
pF1KB8 IVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTV
       .:::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
NP_031 LVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVV
          90       100       110       120       130       140     

            280       290       300       310       320       330  
pF1KB8 ITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKH
       :::::::::::::::::::::::.: :::.::::::::::::::::::::::.::.::::
NP_031 ITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKH
         150       160       170       180       190       200     

            340       350       360       370       380       390  
pF1KB8 SQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKK
       ::::::::::..::::.::.:::::::..    :::.:.:..:.::.:::::::::... 
NP_031 SQFIGYPITLYLEKEREKEISDDEAEEEKG---EKEEEDKDDEEKPKIEDVGSDEEDDSG
         210       220       230          240       250       260  

            400       410       420       430       440       450  
pF1KB8 DGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFS
          ::: ::::::::::::::::::::::::::::.::::::::::::::::::::::::
NP_031 KDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFS
            270       280       290       300       310       320  

            460       470       480       490       500       510  
pF1KB8 VEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVD
       ::::::::::::.:::::::::::.:::::::::::::::::.:.:::::::::::::::
NP_031 VEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVD
            330       340       350       360       370       380  

            520       530       540       550       560       570  
pF1KB8 SEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIH
       :::::::::::::::::::::::::.::::::::.:::::::::::::: ::::.:::::
NP_031 SEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIH
            390       400       410       420       430       440  

            580       590       600       610       620       630  
pF1KB8 EDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVER
       ::: ::..:::::::.:: :::::.::..: .::::.:: :::::::.:.::::::::::
NP_031 EDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVER
            450       460       470       480       490       500  

            640       650       660       670       680       690  
pF1KB8 LRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFEN
       .::.:.::.:: ::::::::::::::.::.::::::::::::::::::::.::.:.::::
NP_031 VRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFEN
            510       520       530       540       550       560  

            700       710       720       730       740       750  
pF1KB8 LCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAA
       :::.::.::.::::::..:::::.:::::::::::::::::::::::::::::::::: :
NP_031 LCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMA
            570       580       590       600       610       620  

            760       770       780       790       800       810  
pF1KB8 KKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYR
       :::::::::: :.::::::::::::::.:::::.::.:::::::::::::::::.:::::
NP_031 KKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYR
            630       640       650       660       670       680  

            820       830       840       850    
pF1KB8 MIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
       :::::::::::. .:.. .::: .:.::::::.:.:::::::
NP_031 MIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD
            690       700       710       720    

>>NP_001258898 (OMIM: 140572) heat shock protein HSP 90-  (724 aa)
 initn: 2811 init1: 2811 opt: 4122  Z-score: 2545.8  bits: 481.9 E(85289): 4.6e-135
Smith-Waterman score: 4122; 85.8% identity (96.0% similar) in 732 aa overlap (123-854:1-724)

            100       110       120       130       140       150  
pF1KB8 VTASLAFRQSQGAGQHLYKDLQPFILLRLLMPEETQTQDQPMEEEEVETFAFQAEIAQLM
                                     ::::..       :::::::::::::::::
NP_001                               MPEEVH-----HGEEEVETFAFQAEIAQLM
                                                  10        20     

            160       170       180       190       200       210  
pF1KB8 SLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLT
       :::::::::::::::::::::.::::::::::::::::::::::::.:..::: :.::::
NP_001 SLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLT
          30        40        50        60        70        80     

            220       230       240       250       260       270  
pF1KB8 IVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTV
       .:::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
NP_001 LVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVV
          90       100       110       120       130       140     

            280       290       300       310       320       330  
pF1KB8 ITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKH
       :::::::::::::::::::::::.: :::.::::::::::::::::::::::.::.::::
NP_001 ITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKH
         150       160       170       180       190       200     

            340       350       360       370       380       390  
pF1KB8 SQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKK
       ::::::::::..::::.::.:::::::..    :::.:.:..:.::.:::::::::... 
NP_001 SQFIGYPITLYLEKEREKEISDDEAEEEKG---EKEEEDKDDEEKPKIEDVGSDEEDDSG
         210       220       230          240       250       260  

            400       410       420       430       440       450  
pF1KB8 DGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFS
          ::: ::::::::::::::::::::::::::::.::::::::::::::::::::::::
NP_001 KDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFS
            270       280       290       300       310       320  

            460       470       480       490       500       510  
pF1KB8 VEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVD
       ::::::::::::.:::::::::::.:::::::::::::::::.:.:::::::::::::::
NP_001 VEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVD
            330       340       350       360       370       380  

            520       530       540       550       560       570  
pF1KB8 SEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIH
       :::::::::::::::::::::::::.::::::::.:::::::::::::: ::::.:::::
NP_001 SEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIH
            390       400       410       420       430       440  

            580       590       600       610       620       630  
pF1KB8 EDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVER
       ::: ::..:::::::.:: :::::.::..: .::::.:: :::::::.:.::::::::::
NP_001 EDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVER
            450       460       470       480       490       500  

            640       650       660       670       680       690  
pF1KB8 LRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFEN
       .::.:.::.:: ::::::::::::::.::.::::::::::::::::::::.::.:.::::
NP_001 VRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFEN
            510       520       530       540       550       560  

            700       710       720       730       740       750  
pF1KB8 LCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAA
       :::.::.::.::::::..:::::.:::::::::::::::::::::::::::::::::: :
NP_001 LCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMA
            570       580       590       600       610       620  

            760       770       780       790       800       810  
pF1KB8 KKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYR
       :::::::::: :.::::::::::::::.:::::.::.:::::::::::::::::.:::::
NP_001 KKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYR
            630       640       650       660       670       680  

            820       830       840       850    
pF1KB8 MIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
       :::::::::::. .:.. .::: .:.::::::.:.:::::::
NP_001 MIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD
            690       700       710       720    

>>NP_001258900 (OMIM: 140572) heat shock protein HSP 90-  (676 aa)
 initn: 3184 init1: 2811 opt: 3462  Z-score: 2141.4  bits: 407.0 E(85289): 1.5e-112
Smith-Waterman score: 3745; 79.9% identity (89.6% similar) in 732 aa overlap (123-854:1-676)

            100       110       120       130       140       150  
pF1KB8 VTASLAFRQSQGAGQHLYKDLQPFILLRLLMPEETQTQDQPMEEEEVETFAFQAEIAQLM
                                     ::::..       :::::::::::::::::
NP_001                               MPEEVH-----HGEEEVETFAFQAEIAQLM
                                                  10        20     

            160       170       180       190       200       210  
pF1KB8 SLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLT
       :::::::::::::::::::::.::::::::::::::::::::::::.:            
NP_001 SLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKI------------
          30        40        50        60        70               

            220       230       240       250       260       270  
pF1KB8 IVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTV
                                           ::::::::::::::::::::::.:
NP_001 ------------------------------------DISMIGQFGVGFYSAYLVAEKVVV
                                                80        90       

            280       290       300       310       320       330  
pF1KB8 ITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKH
       :::::::::::::::::::::::.: :::.::::::::::::::::::::::.::.::::
NP_001 ITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKH
       100       110       120       130       140       150       

            340       350       360       370       380       390  
pF1KB8 SQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKK
       ::::::::::..::::.::.:::::::..    :::.:.:..:.::.:::::::::... 
NP_001 SQFIGYPITLYLEKEREKEISDDEAEEEKG---EKEEEDKDDEEKPKIEDVGSDEEDDSG
       160       170       180          190       200       210    

            400       410       420       430       440       450  
pF1KB8 DGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFS
          ::: ::::::::::::::::::::::::::::.::::::::::::::::::::::::
NP_001 KDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFS
          220       230       240       250       260       270    

            460       470       480       490       500       510  
pF1KB8 VEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVD
       ::::::::::::.:::::::::::.:::::::::::::::::.:.:::::::::::::::
NP_001 VEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVD
          280       290       300       310       320       330    

            520       530       540       550       560       570  
pF1KB8 SEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIH
       :::::::::::::::::::::::::.::::::::.:::::::::::::: ::::.:::::
NP_001 SEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIH
          340       350       360       370       380       390    

            580       590       600       610       620       630  
pF1KB8 EDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVER
       ::: ::..:::::::.:: :::::.::..: .::::.:: :::::::.:.::::::::::
NP_001 EDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVER
          400       410       420       430       440       450    

            640       650       660       670       680       690  
pF1KB8 LRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFEN
       .::.:.::.:: ::::::::::::::.::.::::::::::::::::::::.::.:.::::
NP_001 VRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFEN
          460       470       480       490       500       510    

            700       710       720       730       740       750  
pF1KB8 LCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAA
       :::.::.::.::::::..:::::.:::::::::::::::::::::::::::::::::: :
NP_001 LCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMA
          520       530       540       550       560       570    

            760       770       780       790       800       810  
pF1KB8 KKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYR
       :::::::::: :.::::::::::::::.:::::.::.:::::::::::::::::.:::::
NP_001 KKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYR
          580       590       600       610       620       630    

            820       830       840       850    
pF1KB8 MIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
       :::::::::::. .:.. .::: .:.::::::.:.:::::::
NP_001 MIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD
          640       650       660       670      

>>NP_001258901 (OMIM: 140572) heat shock protein HSP 90-  (714 aa)
 initn: 3438 init1: 2811 opt: 3424  Z-score: 2117.8  bits: 402.7 E(85289): 3.2e-111
Smith-Waterman score: 4029; 84.4% identity (94.7% similar) in 732 aa overlap (123-854:1-714)

            100       110       120       130       140       150  
pF1KB8 VTASLAFRQSQGAGQHLYKDLQPFILLRLLMPEETQTQDQPMEEEEVETFAFQAEIAQLM
                                     ::::..       :::::::::::::::::
NP_001                               MPEEVH-----HGEEEVETFAFQAEIAQLM
                                                  10        20     

            160       170       180       190       200       210  
pF1KB8 SLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLT
       :::::::::::::::::::::.::::::::::::::::::::::::.:..::: :.::::
NP_001 SLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLT
          30        40        50        60        70        80     

            220       230       240       250       260       270  
pF1KB8 IVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTV
       .::::::::::::::::::::::::::::::::          :::::::::::::::.:
NP_001 LVDTGIGMTKADLINNLGTIAKSGTKAFMEALQ----------FGVGFYSAYLVAEKVVV
          90       100       110                 120       130     

            280       290       300       310       320       330  
pF1KB8 ITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKH
       :::::::::::::::::::::::.: :::.::::::::::::::::::::::.::.::::
NP_001 ITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKH
         140       150       160       170       180       190     

            340       350       360       370       380       390  
pF1KB8 SQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKK
       ::::::::::..::::.::.:::::::..    :::.:.:..:.::.:::::::::... 
NP_001 SQFIGYPITLYLEKEREKEISDDEAEEEKG---EKEEEDKDDEEKPKIEDVGSDEEDDSG
         200       210       220          230       240       250  

            400       410       420       430       440       450  
pF1KB8 DGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFS
          ::: ::::::::::::::::::::::::::::.::::::::::::::::::::::::
NP_001 KDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFS
            260       270       280       290       300       310  

            460       470       480       490       500       510  
pF1KB8 VEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVD
       ::::::::::::.:::::::::::.:::::::::::::::::.:.:::::::::::::::
NP_001 VEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVD
            320       330       340       350       360       370  

            520       530       540       550       560       570  
pF1KB8 SEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIH
       :::::::::::::::::::::::::.::::::::.:::::::::::::: ::::.:::::
NP_001 SEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIH
            380       390       400       410       420       430  

            580       590       600       610       620       630  
pF1KB8 EDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVER
       ::: ::..:::::::.:: :::::.::..: .::::.:: :::::::.:.::::::::::
NP_001 EDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVER
            440       450       460       470       480       490  

            640       650       660       670       680       690  
pF1KB8 LRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFEN
       .::.:.::.:: ::::::::::::::.::.::::::::::::::::::::.::.:.::::
NP_001 VRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFEN
            500       510       520       530       540       550  

            700       710       720       730       740       750  
pF1KB8 LCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAA
       :::.::.::.::::::..:::::.:::::::::::::::::::::::::::::::::: :
NP_001 LCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMA
            560       570       580       590       600       610  

            760       770       780       790       800       810  
pF1KB8 KKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYR
       :::::::::: :.::::::::::::::.:::::.::.:::::::::::::::::.:::::
NP_001 KKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYR
            620       630       640       650       660       670  

            820       830       840       850    
pF1KB8 MIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
       :::::::::::. .:.. .::: .:.::::::.:.:::::::
NP_001 MIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD
            680       690       700       710    

>>NP_003290 (OMIM: 191175) endoplasmin precursor [Homo s  (803 aa)
 initn: 1759 init1: 448 opt: 1463  Z-score: 914.5  bits: 180.2 E(85289): 3.4e-44
Smith-Waterman score: 2148; 47.8% identity (74.2% similar) in 730 aa overlap (137-854:71-783)

        110       120       130       140       150       160      
pF1KB8 QHLYKDLQPFILLRLLMPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIF
                                     :. : ::::::. ..:.::::..:.:::::
NP_003 GSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIF
               50        60        70        80        90       100

        170       180       190       200       210       220      
pF1KB8 LRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLI
       :::::::.::::::::  :::: . :....:: ...  .:.   : ..:::.:::. .:.
NP_003 LRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELV
              110       120       130       140       150       160

        230       240           250        260       270       280 
pF1KB8 NNLGTIAKSGTKAFM----EALQAGADIS-MIGQFGVGFYSAYLVAEKVTVITKHNDDEQ
       .::::::::::. :.    :: . : . : .:::::::::::.:::.:: : .:::.: :
NP_003 KNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQ
              170       180       190       200       210       220

             290        300       310       320       330       340
pF1KB8 YAWESSAGGSFTVRTDT-GEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPI
       . :::...  :.: .:  :. .:::: . : :::. ..:::   ::..:::.::::..::
NP_003 HIWESDSN-EFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPI
               230       240       250       260       270         

              350       360       370       380       390       400
pF1KB8 TLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKK
        ..  :    :. ..  ::.:  .::::    ::.:.  .:.    ::::::     : :
NP_003 YVWSSKT---ETVEEPMEEEEAAKEEKE----ESDDEAAVEE----EEEEKKP----KTK
     280          290       300           310           320        

              410       420       430       440       450       460
pF1KB8 KIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFR
       :...   : : .:  :::: :   .. ..::  ::::.... .: .:  ::..::.. :.
NP_003 KVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFK
          330       340       350       360       370       380    

              470         480       490       500       510        
pF1KB8 ALLFVPRRAPFDLFENR--KKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPL
       ..::::  ::  ::..   ::.. :::::::::: :. ....:.::::..:::::.::::
NP_003 SILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPL
          390       400       410       420       430       440    

      520       530       540       550       560       570        
pF1KB8 NISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNR
       :.::: ::: :.::::::.::.: :... ..:.:: :   :...:. :::::. :: .::
NP_003 NVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYN-DTFWKEFGTNIKLGVIEDHSNR
          450       460       470       480        490       500   

      580       590       600       610       620       630        
pF1KB8 KKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGL
        .:..:::. .:    ...:: .:  ::::.: .::...: .. .. .: ::::: :.: 
NP_003 TRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGY
           510       520       530       540       550       560   

      640       650       660       670       680       690        
pF1KB8 EVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMK
       ::::. ::.::::.: : ::.:: . .:.:::... :.:. :...:  . .:: : . ::
NP_003 EVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMK
           570       580       590       600       610       620   

       700       710       720       730       740          750    
pF1KB8 D-ILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQAL---RDNSTMGYMAAKK
       :  :. :.::.:::.::. ::: .:.: :::..::::::::::    .: ::  : . ::
NP_003 DKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKK
           630       640       650       660       670       680   

          760       770       780       790       800       810    
pF1KB8 HLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMI
        .:::: : .:. . .. . :..::.: ::...:.::: : ::. : : .....:: ::.
NP_003 TFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERML
           690       700       710       720       730       740   

          820       830       840       850                        
pF1KB8 KLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD                    
       .:.:.:: :  . ..      :       : . .. ::.:                    
NP_003 RLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL
           750       760       770       780       790       800   

>>XP_011520647 (OMIM: 606219) PREDICTED: heat shock prot  (564 aa)
 initn: 913 init1: 306 opt: 626  Z-score: 403.3  bits: 85.1 E(85289): 1e-15
Smith-Waterman score: 955; 29.9% identity (61.7% similar) in 635 aa overlap (198-814:1-557)

       170       180       190       200       210       220       
pF1KB8 RELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLIN
                                     ..:.:  : .  :.:: :::::::. .:..
XP_011                               MEIHLQTNAEKGTITIQDTGIGMTQEELVS
                                             10        20        30

       230       240       250         260       270       280     
pF1KB8 NLGTIAKSGTKAFMEALQAGADIS--MIGQFGVGFYSAYLVAEKVTVITKHNDDEQ--YA
       ::::::.::.:::..:::  :. :  .:::::::::::..::..: : ..     .  : 
XP_011 NLGTIARSGSKAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVYSRSAAPGSLGYQ
               40        50        60        70        80        90

           290       300       310       320       330       340   
pF1KB8 WESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLF
       : :...: : .   .:  .  :::.:.::: :  :.  : :....: :.:.:...:.   
XP_011 WLSDGSGVFEIAEASG--VRTGTKIIIHLKSDCKEFSSEARVRDVVTKYSNFVSFPL---
              100         110       120       130       140        

           350       360       370       380       390       400   
pF1KB8 VEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIK
                                                                   
XP_011 ------------------------------------------------------------
                                                                   

           410       420       430       440       450       460   
pF1KB8 EKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALL
         :.. ...:  . ::  .: :. . .. :::. ...  .    . :..... :..:...
XP_011 --YLNGRRMNTLQAIWMMDPKDVREWQHEEFYRYVAQAHDKPRYTLHYKTDAPLNIRSIF
           150       160       170       180       190       200   

           470        480       490       500       510       520  
pF1KB8 FVPRRAPFDLFE-NRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISR
       .::   : ..:. .:.  ... :: :.:.:. .  ...:..: ::::::::::.:::.::
XP_011 YVPDMKP-SMFDVSRELGSSVALYSRKVLIQTKATDILPKWLRFIRGVVDSEDIPLNLSR
           210        220       230       240       250       260  

            530       540       550        560       570           
pF1KB8 EMLQQSKILKVIRKNLVKKCLELFTELAE-DKENYKKFYEQFSKNIKLGI--HEDSQNRK
       :.::.: ... .:  : .. ...: . .. : :.: ::.:...  .. ::    ... ..
XP_011 ELLQESALIRKLRDVLQQRLIKFFIDQSKKDAEKYAKFFEDYGLFMREGIVTATEQEVKE
            270       280       290       300       310       320  

     580       590         600       610       620       630       
pF1KB8 KLSELLRYYTSA--SGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHG
        ...:::: .::  :: ...::..: .::. . ..:::. . ..  . .: . : ..:. 
XP_011 DIAKLLRYESSALPSG-QLTSLSEYASRMRAGTRNIYYLCAPNRHLAEHSPYYEAMKKKD
            330        340       350       360       370       380 

       640       650       660       670       680                 
pF1KB8 LEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQE--------EKKTK
        ::.. .: .::  . .:.::. : :.::  . . . . .::: ...        ::.: 
XP_011 TEVLFCFEQFDELTLLHLREFDKKKLISVETD-IVVDHYKEEKFEDRSPAAECLSEKET-
             390       400       410        420       430          

     690       700       710       720       730       740         
pF1KB8 FENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGY
        :.:   :...: ..: .: :. :: : :  ...  .:     ..... : :  ..    
XP_011 -EELMAWMRNVLGSRVTNVKVTLRLDTHPAMVTVLEMG---AARHFLRMQQLAKTQEERA
      440       450       460       470          480       490     

     750       760       770       780       790       800         
pF1KB8 MAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANR
       .  .  ::::: :..:. : :   .. .  ..  ::  .::.:....:. ..::.. ..:
XP_011 QLLQPTLEINPRHALIKKLNQLRASEPGLAQL--LVDQIYENAMIAAGL-VDDPRAMVGR
         500       510       520         530       540        550  

     810       820       830       840       850    
pF1KB8 IYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
       . ...                                        
XP_011 LNELLVKALERH                                 
            560                                     




854 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sun Nov  6 11:17:22 2016 done: Sun Nov  6 11:17:24 2016
 Total Scan time: 12.710 Total Display time:  0.250

Function used was FASTA [36.3.4 Apr, 2011]
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