FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2610, 282 aa 1>>>pF1KE2610 282 - 282 aa - 282 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9360+/-0.000398; mu= 17.1220+/- 0.025 mean_var=61.4270+/-12.633, 0's: 0 Z-trim(111.5): 42 B-trim: 0 in 0/52 Lambda= 0.163642 statistics sampled from 20036 (20078) to 20036 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.593), E-opt: 0.2 (0.235), width: 16 Scan time: 5.910 The best scores are: opt bits E(85289) NP_001643 (OMIM: 601383) aquaporin-6 [Homo sapiens ( 282) 1818 437.8 1.1e-122 NP_000477 (OMIM: 107777,125800) aquaporin-2 [Homo ( 271) 993 243.0 4.6e-64 NP_001642 (OMIM: 600442) aquaporin-5 [Homo sapiens ( 265) 954 233.8 2.7e-61 NP_036196 (OMIM: 154050,615274) lens fiber major i ( 263) 858 211.1 1.8e-54 XP_005268895 (OMIM: 600442) PREDICTED: aquaporin-5 ( 222) 791 195.3 8.9e-50 NP_004019 (OMIM: 600308) aquaporin-4 isoform M23 [ ( 301) 664 165.4 1.2e-40 XP_011524244 (OMIM: 600308) PREDICTED: aquaporin-4 ( 316) 664 165.4 1.3e-40 NP_001641 (OMIM: 600308) aquaporin-4 isoform M1 [H ( 323) 664 165.4 1.3e-40 NP_001304313 (OMIM: 600308) aquaporin-4 isoform M1 ( 352) 664 165.4 1.4e-40 NP_932766 (OMIM: 107776,110450) aquaporin-1 isofor ( 269) 634 158.2 1.5e-38 NP_001316801 (OMIM: 107776,110450) aquaporin-1 iso ( 323) 634 158.3 1.7e-38 XP_016874795 (OMIM: 154050,615274) PREDICTED: lens ( 144) 474 120.3 2.1e-27 XP_011536656 (OMIM: 154050,615274) PREDICTED: lens ( 168) 474 120.3 2.4e-27 NP_001304316 (OMIM: 600308) aquaporin-4 isoform de ( 296) 433 110.8 3.1e-24 NP_001160 (OMIM: 603750) aquaporin-8 [Homo sapiens ( 261) 373 96.6 5.2e-20 XP_011544124 (OMIM: 603750) PREDICTED: aquaporin-8 ( 262) 373 96.6 5.2e-20 XP_011544125 (OMIM: 603750) PREDICTED: aquaporin-8 ( 148) 197 54.9 1.1e-07 NP_001307564 (OMIM: 602914) aquaporin-9 isoform 2 ( 193) 198 55.2 1.1e-07 NP_066190 (OMIM: 602914) aquaporin-9 isoform 1 [Ho ( 295) 198 55.3 1.6e-07 NP_001305086 (OMIM: 602974,614411) aquaporin-7 iso ( 256) 176 50.1 5.1e-06 NP_001305087 (OMIM: 602974,614411) aquaporin-7 iso ( 257) 176 50.1 5.1e-06 XP_016870189 (OMIM: 602974,614411) PREDICTED: aqua ( 341) 176 50.2 6.4e-06 XP_011516168 (OMIM: 602974,614411) PREDICTED: aqua ( 342) 176 50.2 6.4e-06 NP_001161 (OMIM: 602974,614411) aquaporin-7 isofor ( 342) 176 50.2 6.4e-06 XP_005251510 (OMIM: 602974,614411) PREDICTED: aqua ( 342) 176 50.2 6.4e-06 NP_001305073 (OMIM: 600170,607457) aquaporin-3 iso ( 237) 168 48.2 1.8e-05 NP_004916 (OMIM: 600170,607457) aquaporin-3 isofor ( 292) 168 48.3 2.1e-05 NP_001307565 (OMIM: 602914) aquaporin-9 isoform 3 ( 230) 147 43.2 0.00054 NP_945349 (OMIM: 609789) aquaporin-12A precursor [ ( 295) 147 43.3 0.00066 >>NP_001643 (OMIM: 601383) aquaporin-6 [Homo sapiens] (282 aa) initn: 1818 init1: 1818 opt: 1818 Z-score: 2323.5 bits: 437.8 E(85289): 1.1e-122 Smith-Waterman score: 1818; 100.0% identity (100.0% similar) in 282 aa overlap (1-282:1-282) 10 20 30 40 50 60 pF1KE2 MDAVEPGGRGWASMLACRLWKAISRALFAEFLATGLYVFFGVGSVMRWPTALPSVLQIAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDAVEPGGRGWASMLACRLWKAISRALFAEFLATGLYVFFGVGSVMRWPTALPSVLQIAI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 TFNLVTAMAVQVTWKASGAHANPAVTLAFLVGSHISLPRAVAYVAAQLVGATVGAALLYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TFNLVTAMAVQVTWKASGAHANPAVTLAFLVGSHISLPRAVAYVAAQLVGATVGAALLYG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 VMPGDIRETLGINVVRNSVSTGQAVAVELLLTLQLVLCVFASTDSRQTSGSPATMIGISV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VMPGDIRETLGINVVRNSVSTGQAVAVELLLTLQLVLCVFASTDSRQTSGSPATMIGISV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 ALGHLIGIHFTGCSMNPARSFGPAIIIGKFTVHWVFWVGPLMGALLASLIYNFVLFPDTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALGHLIGIHFTGCSMNPARSFGPAIIIGKFTVHWVFWVGPLMGALLASLIYNFVLFPDTK 190 200 210 220 230 240 250 260 270 280 pF1KE2 TLAQRLAILTGTVEVGTGAGAGAEPLKKESQPGSGAVEMESV :::::::::::::::::::::::::::::::::::::::::: NP_001 TLAQRLAILTGTVEVGTGAGAGAEPLKKESQPGSGAVEMESV 250 260 270 280 >>NP_000477 (OMIM: 107777,125800) aquaporin-2 [Homo sapi (271 aa) initn: 977 init1: 574 opt: 993 Z-score: 1271.1 bits: 243.0 E(85289): 4.6e-64 Smith-Waterman score: 993; 62.3% identity (85.4% similar) in 239 aa overlap (19-251:1-239) 10 20 30 40 50 pF1KE2 MDAVEPGGRGWASMLACRLWK----AISRALFAEFLATGLYVFFGVGSVMRWPTALPSVL .:. :.:::.::::::: :.::::.::.. :: :::::: NP_000 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVL 10 20 30 40 60 70 80 90 100 110 pF1KE2 QIAITFNLVTAMAVQVTWKASGAHANPAVTLAFLVGSHISLPRAVAYVAAQLVGATVGAA :::..:.: . ::. . :::: :::::.: ::: :.:. ::. ::::::.::..::: NP_000 QIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAA 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE2 LLYGVMPGDIRETLGINVVRNSVSTGQAVAVELLLTLQLVLCVFASTDSR--QTSGSPAT ::. . :.::: :..:.. ::...::::.:::.::::::::.::::: : .. :.:: NP_000 LLHEITPADIRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPAL 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE2 MIGISVALGHLIGIHFTGCSMNPARSFGPAIIIGKFTVHWVFWVGPLMGALLASLIYNFV ::.:::::::.:::.::::::::::..::.. ::: :::::.:::.::.:.::.::.: NP_000 SIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYV 170 180 190 200 210 220 240 250 260 270 280 pF1KE2 LFPDTKTLAQRLAILTGTVEVGTGAGAGAEPLKKESQPGSGAVEMESV ::: .:.:..:::.: : NP_000 LFPPAKSLSERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA 230 240 250 260 270 >>NP_001642 (OMIM: 600442) aquaporin-5 [Homo sapiens] (265 aa) initn: 955 init1: 564 opt: 954 Z-score: 1221.5 bits: 233.8 E(85289): 2.7e-61 Smith-Waterman score: 954; 58.5% identity (88.1% similar) in 236 aa overlap (22-254:9-244) 10 20 30 40 50 60 pF1KE2 MDAVEPGGRGWASMLACRLWKAISRALFAEFLATGLYVFFGVGSVMRWPTALPSVLQIAI :. .:.::::::: ..::::.::...::.:::..::::. NP_001 MKKEVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALPTILQIAL 10 20 30 40 70 80 90 100 110 120 pF1KE2 TFNLVTAMAVQVTWKASGAHANPAVTLAFLVGSHISLPRAVAYVAAQLVGATVGAALLYG .:.:. . .:. .::.: :::.:::.:::..::: :: ::::::::: .::..::: NP_001 AFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLRAFFYVAAQLVGAIAGAGILYG 50 60 70 80 90 100 130 140 150 160 170 pF1KE2 VMPGDIRETLGINVVRNSVSTGQAVAVELLLTLQLVLCVFASTDSRQTS--GSPATMIGI : : . : .:..:.. :... :::..:::.::.::.::.:::::::.:: :::: ::. NP_001 VAPLNARGNLAVNALNNNTTQGQAMVVELILTFQLALCIFASTDSRRTSPVGSPALSIGL 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE2 SVALGHLIGIHFTGCSMNPARSFGPAIIIGKFT-VHWVFWVGPLMGALLASLIYNFVLFP ::.::::.::.:::::::::::::::.....:. .::::::::..::.::...: ..::: NP_001 SVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPAHWVFWVGPIVGAVLAAILYFYLLFP 170 180 190 200 210 220 240 250 260 270 280 pF1KE2 DTKTLAQRLAILTGTVEVGTGAGAGAEPLKKESQPGSGAVEMESV .. .:..:.::. :: : NP_001 NSLSLSERVAIIKGTYEPDEDWEEQREERKKTMELTTR 230 240 250 260 >>NP_036196 (OMIM: 154050,615274) lens fiber major intri (263 aa) initn: 851 init1: 507 opt: 858 Z-score: 1099.1 bits: 211.1 E(85289): 1.8e-54 Smith-Waterman score: 858; 52.6% identity (83.3% similar) in 251 aa overlap (25-271:11-261) 10 20 30 40 50 60 pF1KE2 MDAVEPGGRGWASMLACRLWKAISRALFAEFLATGLYVFFGVGSVMRWPTALPSVLQIAI ::.::::.:: .:::::.:: .:: . :::.:. NP_036 MWELRSASFWRAIFAEFFATLFYVFFGLGSSLRWAPGPLHVLQVAM 10 20 30 40 70 80 90 100 110 120 pF1KE2 TFNLVTAMAVQVTWKASGAHANPAVTLAFLVGSHISLPRAVAYVAAQLVGATVGAALLYG .:.:. : :: . . ::::.:::::.::::::..:: :: :.::::.::..:::.::. NP_036 AFGLALATLVQSVGHISGAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYS 50 60 70 80 90 100 130 140 150 160 170 pF1KE2 VMPGDIRETLGINVVRNSVSTGQAVAVELLLTLQLVLCVFASTDSRQTS--GSPATMIGI : : .: .:..:... .::.:::..::..::::.:::.::. : :... :: : .:. NP_036 VTPPAVRGNLALNTLHPAVSVGQATTVEIFLTLQFVLCIFATYDERRNGQLGSVALAVGF 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE2 SVALGHLIGIHFTGCSMNPARSFGPAIIIGKFTVHWVFWVGPLMGALLASLIYNFVLFPD :.:::::.:...:: .:::::::.:::. :.:: :::.::::..:. :.::.:.:.::: NP_036 SLALGHLFGMYYTGAGMNPARSFAPAILTGNFTNHWVYWVGPIIGGGLGSLLYDFLLFPR 170 180 190 200 210 220 240 250 260 270 280 pF1KE2 TKTLAQRLAILTGTV-EVGTGAG-AGAEPLKKESQPGSGAVEMESV :....::..: :. .:..: . .::.. ..: NP_036 LKSISERLSVLKGAKPDVSNGQPEVTGEPVELNTQAL 230 240 250 260 >>XP_005268895 (OMIM: 600442) PREDICTED: aquaporin-5 iso (222 aa) initn: 778 init1: 561 opt: 791 Z-score: 1014.7 bits: 195.3 E(85289): 8.9e-50 Smith-Waterman score: 791; 59.7% identity (87.8% similar) in 196 aa overlap (22-214:9-204) 10 20 30 40 50 60 pF1KE2 MDAVEPGGRGWASMLACRLWKAISRALFAEFLATGLYVFFGVGSVMRWPTALPSVLQIAI :. .:.::::::: ..::::.::...::.:::..::::. XP_005 MKKEVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALPTILQIAL 10 20 30 40 70 80 90 100 110 120 pF1KE2 TFNLVTAMAVQVTWKASGAHANPAVTLAFLVGSHISLPRAVAYVAAQLVGATVGAALLYG .:.:. . .:. .::.: :::.:::.:::..::: :: ::::::::: .::..::: XP_005 AFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLRAFFYVAAQLVGAIAGAGILYG 50 60 70 80 90 100 130 140 150 160 170 pF1KE2 VMPGDIRETLGINVVRNSVSTGQAVAVELLLTLQLVLCVFASTDSRQTS--GSPATMIGI : : . : .:..:.. :... :::..:::.::.::.::.:::::::.:: :::: ::. XP_005 VAPLNARGNLAVNALNNNTTQGQAMVVELILTFQLALCIFASTDSRRTSPVGSPALSIGL 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE2 SVALGHLIGIHFTGCSMNPARSFGPAIIIGKFT-VHWVFWVGPLMGALLASLIYNFVLFP ::.::::.::.:::::::::::::::.....:. .:: XP_005 SVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPAHWGLLLSLRGGDTRSVHPSL 170 180 190 200 210 220 240 250 260 270 280 pF1KE2 DTKTLAQRLAILTGTVEVGTGAGAGAEPLKKESQPGSGAVEMESV >>NP_004019 (OMIM: 600308) aquaporin-4 isoform M23 [Homo (301 aa) initn: 602 init1: 313 opt: 664 Z-score: 850.7 bits: 165.4 E(85289): 1.2e-40 Smith-Waterman score: 664; 44.3% identity (77.9% similar) in 235 aa overlap (14-240:1-235) 10 20 30 40 50 pF1KE2 MDAVEPGGRGWASMLACR-LW-KAISRALFAEFLATGLYVFFGVGSVMRW---PTALP-S :.: . .: .:. .:. ::::: ..:....::.. : :: . NP_004 MVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVD 10 20 30 40 60 70 80 90 100 110 pF1KE2 VLQIAITFNLVTAMAVQVTWKASGAHANPAVTLAFLVGSHISLPRAVAYVAAQLVGATVG .. :.. :.: : :: . ::.: :::::.:.. .::. ..: :.::: .:: .: NP_004 MVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIG 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE2 AALLYGVMPGDIRETLGINVVRNSVSTGQAVAVELLLTLQLVLCVFASTDSRQT--SGSP :..:: : : .. ::...:......:... :::..:.:::. .::: ::..: .:: NP_004 AGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSI 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE2 ATMIGISVALGHLIGIHFTGCSMNPARSFGPAIIIGKFTVHWVFWVGPLMGALLASLIYN : ::.:::.:::..:..:: :::::::::::.:.:.. ::..::::..::.::. .:. NP_004 ALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYE 170 180 190 200 210 220 240 250 260 270 280 pF1KE2 FVLFPDTKTLAQRLAILTGTVEVGTGAGAGAEPLKKESQPGSGAVEMESV .:. ::.. NP_004 YVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVIDVDRGEE 230 240 250 260 270 280 >>XP_011524244 (OMIM: 600308) PREDICTED: aquaporin-4 iso (316 aa) initn: 602 init1: 313 opt: 664 Z-score: 850.4 bits: 165.4 E(85289): 1.3e-40 Smith-Waterman score: 664; 44.3% identity (77.9% similar) in 235 aa overlap (14-240:16-250) 10 20 30 40 50 pF1KE2 MDAVEPGGRGWASMLACR-LW-KAISRALFAEFLATGLYVFFGVGSVMRW---PTALP :.: . .: .:. .:. ::::: ..:....::.. : :: XP_011 MFEIKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 -SVLQIAITFNLVTAMAVQVTWKASGAHANPAVTLAFLVGSHISLPRAVAYVAAQLVGAT ... :.. :.: : :: . ::.: :::::.:.. .::. ..: :.::: .:: XP_011 VDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAI 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 VGAALLYGVMPGDIRETLGINVVRNSVSTGQAVAVELLLTLQLVLCVFASTDSRQT--SG .::..:: : : .. ::...:......:... :::..:.:::. .::: ::..: .: XP_011 IGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTG 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE2 SPATMIGISVALGHLIGIHFTGCSMNPARSFGPAIIIGKFTVHWVFWVGPLMGALLASLI : : ::.:::.:::..:..:: :::::::::::.:.:.. ::..::::..::.::. . XP_011 SIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGL 190 200 210 220 230 240 240 250 260 270 280 pF1KE2 YNFVLFPDTKTLAQRLAILTGTVEVGTGAGAGAEPLKKESQPGSGAVEMESV :..:. ::.. XP_011 YEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVIDVDRG 250 260 270 280 290 300 >>NP_001641 (OMIM: 600308) aquaporin-4 isoform M1 [Homo (323 aa) initn: 602 init1: 313 opt: 664 Z-score: 850.2 bits: 165.4 E(85289): 1.3e-40 Smith-Waterman score: 664; 44.3% identity (77.9% similar) in 235 aa overlap (14-240:23-257) 10 20 30 40 pF1KE2 MDAVEPGGRGWASMLACR-LW-KAISRALFAEFLATGLYVFFGVGSVMRW- :.: . .: .:. .:. ::::: ..:....::.. : NP_001 MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE2 --PTALP-SVLQIAITFNLVTAMAVQVTWKASGAHANPAVTLAFLVGSHISLPRAVAYVA :: ... :.. :.: : :: . ::.: :::::.:.. .::. ..: :.: NP_001 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE2 AQLVGATVGAALLYGVMPGDIRETLGINVVRNSVSTGQAVAVELLLTLQLVLCVFASTDS :: .:: .::..:: : : .. ::...:......:... :::..:.:::. .::: :: NP_001 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE2 RQT--SGSPATMIGISVALGHLIGIHFTGCSMNPARSFGPAIIIGKFTVHWVFWVGPLMG ..: .:: : ::.:::.:::..:..:: :::::::::::.:.:.. ::..::::..: NP_001 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE2 ALLASLIYNFVLFPDTKTLAQRLAILTGTVEVGTGAGAGAEPLKKESQPGSGAVEMESV :.::. .:..:. ::.. NP_001 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH 250 260 270 280 290 300 >>NP_001304313 (OMIM: 600308) aquaporin-4 isoform M1x [H (352 aa) initn: 602 init1: 313 opt: 664 Z-score: 849.7 bits: 165.4 E(85289): 1.4e-40 Smith-Waterman score: 664; 44.3% identity (77.9% similar) in 235 aa overlap (14-240:23-257) 10 20 30 40 pF1KE2 MDAVEPGGRGWASMLACR-LW-KAISRALFAEFLATGLYVFFGVGSVMRW- :.: . .: .:. .:. ::::: ..:....::.. : NP_001 MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE2 --PTALP-SVLQIAITFNLVTAMAVQVTWKASGAHANPAVTLAFLVGSHISLPRAVAYVA :: ... :.. :.: : :: . ::.: :::::.:.. .::. ..: :.: NP_001 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE2 AQLVGATVGAALLYGVMPGDIRETLGINVVRNSVSTGQAVAVELLLTLQLVLCVFASTDS :: .:: .::..:: : : .. ::...:......:... :::..:.:::. .::: :: NP_001 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE2 RQT--SGSPATMIGISVALGHLIGIHFTGCSMNPARSFGPAIIIGKFTVHWVFWVGPLMG ..: .:: : ::.:::.:::..:..:: :::::::::::.:.:.. ::..::::..: NP_001 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE2 ALLASLIYNFVLFPDTKTLAQRLAILTGTVEVGTGAGAGAEPLKKESQPGSGAVEMESV :.::. .:..:. ::.. NP_001 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH 250 260 270 280 290 300 >>NP_932766 (OMIM: 107776,110450) aquaporin-1 isoform 1 (269 aa) initn: 697 init1: 326 opt: 634 Z-score: 813.1 bits: 158.2 E(85289): 1.5e-38 Smith-Waterman score: 686; 46.2% identity (76.2% similar) in 240 aa overlap (25-254:12-251) 10 20 30 40 50 pF1KE2 MDAVEPGGRGWASMLACRLWKAISRALFAEFLATGLYVFFGVGSVM--RWP-----TALP ::. :::::: :.::...::.. ..: ::. NP_932 MASEFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQ 10 20 30 40 60 70 80 90 100 110 pF1KE2 SVLQIAITFNLVTAMAVQVTWKASGAHANPAVTLAFLVGSHISLPRAVAYVAAQLVGATV . ......:.: : .: . . :::: ::::::..:.. .::. ::. :. :: ::: : NP_932 DNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISIFRALMYIIAQCVGAIV 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE2 GAALLYGVMPGDIRETLGINVVRNSVSTGQAVAVELLLTLQLVLCVFASTDSRQTS--GS ..:.: :. . ..:: : . ..:..::....:.. ::::::::.:.:: :. . :: NP_932 ATAILSGITSSLTGNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGS 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE2 PATMIGISVALGHLIGIHFTGCSMNPARSFGPAIIIGKFTVHWVFWVGPLMGALLASLIY ::.:::::::..: .:::..::::::: :.: .:. ::.:::::..:. :: ::: NP_932 APLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIY 170 180 190 200 210 220 240 250 260 270 280 pF1KE2 NFVLFPDTKTLAQRLAILT-GTVEVGTGAGAGAEPLKKESQPGSGAVEMESV .:.: : .. :..:. . : : :: NP_932 DFILAPRSSDLTDRVKVWTSGQVEEYDLDADDINSRVEMKPK 230 240 250 260 282 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 17:03:34 2016 done: Tue Nov 8 17:03:35 2016 Total Scan time: 5.910 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]