FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2627, 271 aa 1>>>pF1KE2627 271 - 271 aa - 271 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9281+/-0.000359; mu= 17.0555+/- 0.022 mean_var=66.1578+/-13.886, 0's: 0 Z-trim(113.9): 44 B-trim: 0 in 0/51 Lambda= 0.157683 statistics sampled from 23345 (23391) to 23345 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.651), E-opt: 0.2 (0.274), width: 16 Scan time: 7.470 The best scores are: opt bits E(85289) NP_000477 (OMIM: 107777,125800) aquaporin-2 [Homo ( 271) 1772 411.8 6.7e-115 NP_001642 (OMIM: 600442) aquaporin-5 [Homo sapiens ( 265) 1158 272.1 7.4e-73 NP_036196 (OMIM: 154050,615274) lens fiber major i ( 263) 1082 254.8 1.2e-67 NP_001643 (OMIM: 601383) aquaporin-6 [Homo sapiens ( 282) 993 234.6 1.5e-61 XP_005268895 (OMIM: 600442) PREDICTED: aquaporin-5 ( 222) 916 217.0 2.4e-56 NP_004019 (OMIM: 600308) aquaporin-4 isoform M23 [ ( 301) 776 185.3 1.2e-46 XP_011524244 (OMIM: 600308) PREDICTED: aquaporin-4 ( 316) 776 185.3 1.2e-46 NP_001641 (OMIM: 600308) aquaporin-4 isoform M1 [H ( 323) 776 185.3 1.2e-46 NP_001304313 (OMIM: 600308) aquaporin-4 isoform M1 ( 352) 776 185.3 1.3e-46 NP_932766 (OMIM: 107776,110450) aquaporin-1 isofor ( 269) 768 183.4 3.8e-46 NP_001316801 (OMIM: 107776,110450) aquaporin-1 iso ( 323) 768 183.5 4.4e-46 XP_016874795 (OMIM: 154050,615274) PREDICTED: lens ( 144) 563 136.6 2.6e-32 XP_011536656 (OMIM: 154050,615274) PREDICTED: lens ( 168) 563 136.6 2.9e-32 NP_001304316 (OMIM: 600308) aquaporin-4 isoform de ( 296) 555 135.0 1.6e-31 NP_001160 (OMIM: 603750) aquaporin-8 [Homo sapiens ( 261) 420 104.2 2.5e-22 XP_011544124 (OMIM: 603750) PREDICTED: aquaporin-8 ( 262) 420 104.2 2.5e-22 NP_001307564 (OMIM: 602914) aquaporin-9 isoform 2 ( 193) 196 53.2 4.4e-07 NP_066190 (OMIM: 602914) aquaporin-9 isoform 1 [Ho ( 295) 196 53.3 6.1e-07 NP_001305086 (OMIM: 602974,614411) aquaporin-7 iso ( 256) 191 52.1 1.2e-06 NP_001305087 (OMIM: 602974,614411) aquaporin-7 iso ( 257) 191 52.1 1.2e-06 XP_016870189 (OMIM: 602974,614411) PREDICTED: aqua ( 341) 191 52.2 1.5e-06 XP_005251510 (OMIM: 602974,614411) PREDICTED: aqua ( 342) 191 52.2 1.5e-06 XP_011516168 (OMIM: 602974,614411) PREDICTED: aqua ( 342) 191 52.2 1.5e-06 NP_001161 (OMIM: 602974,614411) aquaporin-7 isofor ( 342) 191 52.2 1.5e-06 XP_011544125 (OMIM: 603750) PREDICTED: aquaporin-8 ( 148) 184 50.4 2.4e-06 XP_016870194 (OMIM: 602974,614411) PREDICTED: aqua ( 250) 183 50.3 4.1e-06 XP_016870193 (OMIM: 602974,614411) PREDICTED: aqua ( 250) 183 50.3 4.1e-06 XP_016870190 (OMIM: 602974,614411) PREDICTED: aqua ( 250) 183 50.3 4.1e-06 XP_016870192 (OMIM: 602974,614411) PREDICTED: aqua ( 250) 183 50.3 4.1e-06 XP_016870191 (OMIM: 602974,614411) PREDICTED: aqua ( 250) 183 50.3 4.1e-06 NP_001305073 (OMIM: 600170,607457) aquaporin-3 iso ( 237) 182 50.1 4.7e-06 NP_004916 (OMIM: 600170,607457) aquaporin-3 isofor ( 292) 180 49.7 7.5e-06 NP_536354 (OMIM: 606578) aquaporin-10 [Homo sapien ( 301) 151 43.1 0.00074 NP_001307565 (OMIM: 602914) aquaporin-9 isoform 3 ( 230) 148 42.3 0.00097 XP_016870195 (OMIM: 602974,614411) PREDICTED: aqua ( 200) 143 41.1 0.0019 XP_011508406 (OMIM: 606578) PREDICTED: aquaporin-1 ( 302) 145 41.7 0.0019 NP_001305085 (OMIM: 602974,614411) aquaporin-7 iso ( 216) 143 41.2 0.002 XP_006716828 (OMIM: 602974,614411) PREDICTED: aqua ( 285) 143 41.3 0.0025 XP_011516169 (OMIM: 602974,614411) PREDICTED: aqua ( 285) 143 41.3 0.0025 >>NP_000477 (OMIM: 107777,125800) aquaporin-2 [Homo sapi (271 aa) initn: 1772 init1: 1772 opt: 1772 Z-score: 2183.8 bits: 411.8 E(85289): 6.7e-115 Smith-Waterman score: 1772; 100.0% identity (100.0% similar) in 271 aa overlap (1-271:1-271) 10 20 30 40 50 60 pF1KE2 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQALG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQALG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 HISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 HISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVNA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYTG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 CSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFPPAKSLSERLAVLKGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 CSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFPPAKSLSERLAVLKGL 190 200 210 220 230 240 250 260 270 pF1KE2 EPDTDWEEREVRRRQSVELHSPQSLPRGTKA ::::::::::::::::::::::::::::::: NP_000 EPDTDWEEREVRRRQSVELHSPQSLPRGTKA 250 260 270 >>NP_001642 (OMIM: 600442) aquaporin-5 [Homo sapiens] (265 aa) initn: 1170 init1: 892 opt: 1158 Z-score: 1429.0 bits: 272.1 E(85289): 7.4e-73 Smith-Waterman score: 1158; 66.0% identity (90.3% similar) in 259 aa overlap (3-259:4-262) 10 20 30 40 50 pF1KE2 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQAL :. :.:: .::::::::::.::::::::::.::.:::..::::.::::.::::.::: NP_001 MKKEVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALPTILQIALAFGLAIGTLAQAL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 GHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVN : .::.:::::.:.: ::: ..:.::: :::::::.::.:::..:. ..: . ::.:::: NP_001 GPVSGGHINPAITLALLVGNQISLLRAFFYVAAQLVGAIAGAGILYGVAPLNARGNLAVN 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 ALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYT ::.:.:: :::..:::.::.::.:::::::: :: :.::::::.::.::::.::..: NP_001 ALNNNTTQGQAMVVELILTFQLALCIFASTDSRRTSPVGSPALSIGLSVTLGHLVGIYFT 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE2 GCSMNPARSLAPAVVTGKFDD-HWVFWIGPLVGAILGSLLYNYVLFPPAKSLSERLAVLK :::::::::..:::: ..:. :::::.::.:::.:...:: :.::: . :::::.:..: NP_001 GCSMNPARSFGPAVVMNRFSPAHWVFWVGPIVGAVLAAILYFYLLFPNSLSLSERVAIIK 190 200 210 220 230 240 240 250 260 270 pF1KE2 GL-EPDTDWEEREVRRRQSVELHSPQSLPRGTKA : ::: ::::.. .:....:: NP_001 GTYEPDEDWEEQREERKKTMELTTR 250 260 >>NP_036196 (OMIM: 154050,615274) lens fiber major intri (263 aa) initn: 1077 init1: 1077 opt: 1082 Z-score: 1335.6 bits: 254.8 E(85289): 1.2e-67 Smith-Waterman score: 1082; 61.5% identity (86.4% similar) in 265 aa overlap (1-265:1-263) 10 20 30 40 50 60 pF1KE2 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQALG :::::: .: ::.::::.:::..:::::::.: : . :::.::::::...::::..: NP_036 MWELRSASFWRAIFAEFFATLFYVFFGLGSSLRWAPGPLHVLQVAMAFGLALATLVQSVG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 HISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVNA ::::::.::::: : ::: ..:.::: :.::::::::::::.:. .:: .::.::.:. NP_036 HISGAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYTG : ....:::.:::.:::::.::::::. ::::. . :. ::..:::.:::::.:..::: NP_036 LHPAVSVGQATTVEIFLTLQFVLCIFATYDERRNGQLGSVALAVGFSLALGHLFGMYYTG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 CSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFPPAKSLSERLAVLKGL .::::::.:::..::.: .:::.:.::..:. ::::::...::: ::.::::.:::: NP_036 AGMNPARSFAPAILTGNFTNHWVYWVGPIIGGGLGSLLYDFLLFPRLKSISERLSVLKGA 190 200 210 220 230 240 250 260 270 pF1KE2 EPDTDWEEREVRRRQSVELHSPQSLPRGTKA .::.. . :: . :::.. :.: NP_036 KPDVSNGQPEVTG-EPVELNT-QAL 250 260 >>NP_001643 (OMIM: 601383) aquaporin-6 [Homo sapiens] (282 aa) initn: 977 init1: 574 opt: 993 Z-score: 1225.8 bits: 234.6 E(85289): 1.5e-61 Smith-Waterman score: 993; 62.3% identity (85.4% similar) in 239 aa overlap (1-239:19-251) 10 20 30 40 pF1KE2 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVL .:. :.:::.::::::: :.::::.::.. :: :::::: NP_001 MDAVEPGGRGWASMLACRLWK----AISRALFAEFLATGLYVFFGVGSVMRWPTALPSVL 10 20 30 40 50 50 60 70 80 90 100 pF1KE2 QIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAA :::..:.: . ::. . :::: :::::.: ::: :.:. ::. ::::::.::..::: NP_001 QIAITFNLVTAMAVQVTWKASGAHANPAVTLAFLVGSHISLPRAVAYVAAQLVGATVGAA 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE2 LLHEITPADIRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPAL ::. . :.::: :..:.. ::...::::.:::.::::::::.::::: : .. :.:: NP_001 LLYGVMPGDIRETLGINVVRNSVSTGQAVAVELLLTLQLVLCVFASTDSR--QTSGSPAT 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE2 SIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYV ::.:::::::.:::.::::::::::..::.. ::: :::::.:::.::.:.::.::.: NP_001 MIGISVALGHLIGIHFTGCSMNPARSFGPAIIIGKFTVHWVFWVGPLMGALLASLIYNFV 180 190 200 210 220 230 230 240 250 260 270 pF1KE2 LFPPAKSLSERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA ::: .:.:..:::.: : NP_001 LFPDTKTLAQRLAILTGTVEVGTGAGAGAEPLKKESQPGSGAVEMESV 240 250 260 270 280 >>XP_005268895 (OMIM: 600442) PREDICTED: aquaporin-5 iso (222 aa) initn: 918 init1: 892 opt: 916 Z-score: 1132.6 bits: 217.0 E(85289): 2.4e-56 Smith-Waterman score: 916; 68.7% identity (91.0% similar) in 201 aa overlap (3-202:4-204) 10 20 30 40 50 pF1KE2 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQAL :. :.:: .::::::::::.::::::::::.::.:::..::::.::::.::::.::: XP_005 MKKEVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALPTILQIALAFGLAIGTLAQAL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 GHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVN : .::.:::::.:.: ::: ..:.::: :::::::.::.:::..:. ..: . ::.:::: XP_005 GPVSGGHINPAITLALLVGNQISLLRAFFYVAAQLVGAIAGAGILYGVAPLNARGNLAVN 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 ALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYT ::.:.:: :::..:::.::.::.:::::::: :: :.::::::.::.::::.::..: XP_005 ALNNNTTQGQAMVVELILTFQLALCIFASTDSRRTSPVGSPALSIGLSVTLGHLVGIYFT 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE2 GCSMNPARSLAPAVVTGKFDD-HWVFWIGPLVGAILGSLLYNYVLFPPAKSLSERLAVLK :::::::::..:::: ..:. :: XP_005 GCSMNPARSFGPAVVMNRFSPAHWGLLLSLRGGDTRSVHPSL 190 200 210 220 >>NP_004019 (OMIM: 600308) aquaporin-4 isoform M23 [Homo (301 aa) initn: 775 init1: 677 opt: 776 Z-score: 958.6 bits: 185.3 E(85289): 1.2e-46 Smith-Waterman score: 776; 51.4% identity (82.9% similar) in 222 aa overlap (8-225:11-232) 10 20 30 40 50 pF1KE2 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNW---PQALP-SVLQIAMAFGLGIG :: .:: ::::: :.::...:::..:: . :: ... :.. :::.:. NP_004 MVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 TLVQALGHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIR :.:: .:::::.::::::::: . ..:. ...::.::: :::. ::..:. .:: .. NP_004 TMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 GDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHL : :.:. . .. :::... :::..:.:::. :::: : .: . :. ::.::::::.::: NP_004 GGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE2 LGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFPPAKSLSER ..:.::: :::::::..:::. :....::..:.::..::.:.. ::.::. : NP_004 FAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRF 190 200 210 220 230 240 240 250 260 270 pF1KE2 LAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA NP_004 KEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVIDVDRGEEKKGKDQSGEVLSS 250 260 270 280 290 300 >>XP_011524244 (OMIM: 600308) PREDICTED: aquaporin-4 iso (316 aa) initn: 775 init1: 677 opt: 776 Z-score: 958.3 bits: 185.3 E(85289): 1.2e-46 Smith-Waterman score: 776; 51.4% identity (82.9% similar) in 222 aa overlap (8-225:26-247) 10 20 30 pF1KE2 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNW---PQALP :: .:: ::::: :.::...:::..:: . :: XP_011 MFEIKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLP 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE2 -SVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAV ... :.. :::.:.:.:: .:::::.::::::::: . ..:. ...::.::: :::. XP_011 VDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAI 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE2 AGAALLHEITPADIRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPG ::..:. .:: .. : :.:. . .. :::... :::..:.:::. :::: : .: . : XP_011 IGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTG 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE2 TPALSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLL . ::.::::::.:::..:.::: :::::::..:::. :....::..:.::..::.:.. : XP_011 SIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGL 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE2 YNYVLFPPAKSLSERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA :.::. : XP_011 YEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVIDVDRG 250 260 270 280 290 300 >>NP_001641 (OMIM: 600308) aquaporin-4 isoform M1 [Homo (323 aa) initn: 775 init1: 677 opt: 776 Z-score: 958.2 bits: 185.3 E(85289): 1.2e-46 Smith-Waterman score: 776; 51.4% identity (82.9% similar) in 222 aa overlap (8-225:33-254) 10 20 30 pF1KE2 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNW--- :: .:: ::::: :.::...:::..:: NP_001 DRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGT 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE2 PQALP-SVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQ . :: ... :.. :::.:.:.:: .:::::.::::::::: . ..:. ...::.::: NP_001 EKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQ 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE2 LLGAVAGAALLHEITPADIRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERR :::. ::..:. .:: .. : :.:. . .. :::... :::..:.:::. :::: : .: NP_001 CLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKR 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE2 GENPGTPALSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAI . :. ::.::::::.:::..:.::: :::::::..:::. :....::..:.::..::. NP_001 TDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAV 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE2 LGSLLYNYVLFPPAKSLSERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA :.. ::.::. : NP_001 LAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVI 250 260 270 280 290 300 >>NP_001304313 (OMIM: 600308) aquaporin-4 isoform M1x [H (352 aa) initn: 775 init1: 677 opt: 776 Z-score: 957.6 bits: 185.3 E(85289): 1.3e-46 Smith-Waterman score: 776; 51.4% identity (82.9% similar) in 222 aa overlap (8-225:33-254) 10 20 30 pF1KE2 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNW--- :: .:: ::::: :.::...:::..:: NP_001 DRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGT 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE2 PQALP-SVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQ . :: ... :.. :::.:.:.:: .:::::.::::::::: . ..:. ...::.::: NP_001 EKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQ 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE2 LLGAVAGAALLHEITPADIRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERR :::. ::..:. .:: .. : :.:. . .. :::... :::..:.:::. :::: : .: NP_001 CLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKR 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE2 GENPGTPALSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAI . :. ::.::::::.:::..:.::: :::::::..:::. :....::..:.::..::. NP_001 TDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAV 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE2 LGSLLYNYVLFPPAKSLSERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA :.. ::.::. : NP_001 LAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVI 250 260 270 280 290 300 >>NP_932766 (OMIM: 107776,110450) aquaporin-1 isoform 1 (269 aa) initn: 787 init1: 664 opt: 768 Z-score: 949.4 bits: 183.4 E(85289): 3.8e-46 Smith-Waterman score: 768; 45.0% identity (79.6% similar) in 260 aa overlap (3-254:4-263) 10 20 30 40 50 pF1KE2 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALN--WP-----QALPSVLQIAMAFGLGI :... : ::: :::::: ::::...::::. .: :. . .....::::.: NP_932 MASEFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSI 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 GTLVQALGHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADI .::.:..:::::::.:::::.. :..:..:..:: .:. :: .::....:.: :: . NP_932 ATLAQSVGHISGAHLNPAVTLGLLLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLT 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 RGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGH ..:. : :......::.. .:.. :::::::..:.::.:: . :. :.::.:::::: NP_932 GNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGH 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE2 LLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFPPAKSLSE ::.: ::::..:::::.. ::.: .:..::.::.::..:. :. :.:...: : ...:.. NP_932 LLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFILAPRSSDLTD 190 200 210 220 230 240 240 250 260 270 pF1KE2 RLAV-LKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA :. : .: . : . .. : NP_932 RVKVWTSGQVEEYDLDADDINSRVEMKPK 250 260 271 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 10:52:21 2016 done: Sun Nov 6 10:52:22 2016 Total Scan time: 7.470 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]