FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2492, 1788 aa 1>>>pF1KE2492 1788 - 1788 aa - 1788 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.3657+/-0.000549; mu= 14.8890+/- 0.034 mean_var=163.6956+/-34.522, 0's: 0 Z-trim(111.5): 149 B-trim: 675 in 1/56 Lambda= 0.100243 statistics sampled from 20029 (20177) to 20029 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.576), E-opt: 0.2 (0.237), width: 16 Scan time: 12.940 The best scores are: opt bits E(85289) NP_003165 (OMIM: 604126) supervillin isoform 1 [Ho (1788) 11832 1725.5 0 XP_016872071 (OMIM: 604126) PREDICTED: supervillin (1873) 11832 1725.6 0 XP_011517935 (OMIM: 604126) PREDICTED: supervillin (2267) 10042 1466.8 0 NP_001310529 (OMIM: 604126) supervillin isoform 4 (1820) 9584 1400.4 0 XP_016872070 (OMIM: 604126) PREDICTED: supervillin (1905) 9584 1400.5 0 NP_001310528 (OMIM: 604126) supervillin isoform 3 (1904) 9557 1396.6 0 XP_016872068 (OMIM: 604126) PREDICTED: supervillin (1989) 9557 1396.6 0 NP_068506 (OMIM: 604126) supervillin isoform 2 [Ho (2214) 9557 1396.6 0 XP_016872066 (OMIM: 604126) PREDICTED: supervillin (2299) 9557 1396.6 0 XP_011517932 (OMIM: 604126) PREDICTED: supervillin (2315) 7024 1030.3 0 XP_016872069 (OMIM: 604126) PREDICTED: supervillin (1974) 7020 1029.7 0 XP_011517940 (OMIM: 604126) PREDICTED: supervillin (1915) 7019 1029.5 0 XP_011517939 (OMIM: 604126) PREDICTED: supervillin (1947) 7019 1029.5 0 XP_016872067 (OMIM: 604126) PREDICTED: supervillin (1999) 7019 1029.5 0 XP_011517938 (OMIM: 604126) PREDICTED: supervillin (2031) 7019 1029.5 0 XP_005252630 (OMIM: 604126) PREDICTED: supervillin (2256) 7019 1029.6 0 XP_011517937 (OMIM: 604126) PREDICTED: supervillin (2256) 7019 1029.6 0 XP_005252628 (OMIM: 604126) PREDICTED: supervillin (2256) 7019 1029.6 0 XP_011517936 (OMIM: 604126) PREDICTED: supervillin (2256) 7019 1029.6 0 XP_005252627 (OMIM: 604126) PREDICTED: supervillin (2256) 7019 1029.6 0 XP_011517934 (OMIM: 604126) PREDICTED: supervillin (2284) 7019 1029.6 0 XP_011517933 (OMIM: 604126) PREDICTED: supervillin (2309) 7019 1029.6 0 XP_016872065 (OMIM: 604126) PREDICTED: supervillin (2314) 7019 1029.6 0 XP_016872064 (OMIM: 604126) PREDICTED: supervillin (2341) 7019 1029.6 0 XP_016872072 (OMIM: 604126) PREDICTED: supervillin (1274) 2545 382.3 1.6e-104 NP_009058 (OMIM: 193040) villin-1 [Homo sapiens] ( 827) 251 50.4 8.5e-05 NP_001738 (OMIM: 153615) macrophage-capping protei ( 348) 235 47.8 0.00022 XP_011531425 (OMIM: 153615) PREDICTED: macrophage- ( 348) 235 47.8 0.00022 NP_001243068 (OMIM: 153615) macrophage-capping pro ( 348) 235 47.8 0.00022 NP_001307661 (OMIM: 153615) macrophage-capping pro ( 348) 235 47.8 0.00022 NP_001307662 (OMIM: 153615) macrophage-capping pro ( 348) 235 47.8 0.00022 XP_011531424 (OMIM: 153615) PREDICTED: macrophage- ( 348) 235 47.8 0.00022 NP_001106177 (OMIM: 613416) adseverin isoform 1 [H ( 715) 234 47.9 0.00042 XP_016861969 (OMIM: 161565) PREDICTED: NK-tumor re (1094) 216 45.4 0.0035 XP_016861968 (OMIM: 161565) PREDICTED: NK-tumor re (1095) 216 45.4 0.0035 XP_016861967 (OMIM: 161565) PREDICTED: NK-tumor re (1095) 216 45.4 0.0035 XP_016861966 (OMIM: 161565) PREDICTED: NK-tumor re (1163) 216 45.5 0.0036 XP_016861965 (OMIM: 161565) PREDICTED: NK-tumor re (1163) 216 45.5 0.0036 XP_011532052 (OMIM: 161565) PREDICTED: NK-tumor re (1210) 216 45.5 0.0038 XP_016861964 (OMIM: 161565) PREDICTED: NK-tumor re (1210) 216 45.5 0.0038 XP_011532049 (OMIM: 161565) PREDICTED: NK-tumor re (1210) 216 45.5 0.0038 XP_006713236 (OMIM: 161565) PREDICTED: NK-tumor re (1353) 216 45.5 0.0041 NP_005376 (OMIM: 161565) NK-tumor recognition prot (1462) 216 45.6 0.0043 XP_005265230 (OMIM: 161565) PREDICTED: NK-tumor re (1463) 216 45.6 0.0043 >>NP_003165 (OMIM: 604126) supervillin isoform 1 [Homo s (1788 aa) initn: 11832 init1: 11832 opt: 11832 Z-score: 9254.3 bits: 1725.5 E(85289): 0 Smith-Waterman score: 11832; 100.0% identity (100.0% similar) in 1788 aa overlap (1-1788:1-1788) 10 20 30 40 50 60 pF1KE2 MKRKERIARRLEGIENDTQPILLQSCTGLVTHRLLEEDTPRYMRASDPASPHIGRSNEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MKRKERIARRLEGIENDTQPILLQSCTGLVTHRLLEEDTPRYMRASDPASPHIGRSNEEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRRQLAEKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRRQLAEKY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 GLTLDPEADSEYLSRYTKSRKEPDAVEKRGGKSDKQEESSRDASSLYPGTETMGLRTCAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GLTLDPEADSEYLSRYTKSRKEPDAVEKRGGKSDKQEESSRDASSLYPGTETMGLRTCAG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 ESKDYALHVGDGSSDPEVLLNIENQRRGQELSATRQAHDLSPAAESSSTFSFSGRDSSFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ESKDYALHVGDGSSDPEVLLNIENQRRGQELSATRQAHDLSPAAESSSTFSFSGRDSSFT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 EVPRSPKHAHSSSLQQAASRSPSFGDPQLSPEARPRCTSHSETPTVDDEEKVDERAKLSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EVPRSPKHAHSSSLQQAASRSPSFGDPQLSPEARPRCTSHSETPTVDDEEKVDERAKLSV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 AAKRLLFREMEKSFDEQNVPKRRSRNTAVEQRLRRLQDRSLTQPITTEEVVIAATLQASA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 AAKRLLFREMEKSFDEQNVPKRRSRNTAVEQRLRRLQDRSLTQPITTEEVVIAATLQASA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 HQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQRRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 HQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQRRM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 NARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNASA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 NARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNASA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 TDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGMEKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGMEKY 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 GSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMNAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMNAQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 GNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWKPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWKPQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 DSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRNRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRNRL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 SRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRGAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRGAA 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 NDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESDLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 NDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESDLK 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 LDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPVEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPVEM 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 DEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLNVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLNVA 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 FMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLMLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 FMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLMLL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 QIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQTK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 RELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNCIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNCIY 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE2 RLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAKHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAKHL 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE2 WNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTELK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 WNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTELK 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE2 RSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDRRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDRRQ 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE2 FEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 FEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAA 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE2 GKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMVVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMVVH 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KE2 SGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYLWH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYLWH 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KE2 GCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDRKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDRKA 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 1620 pF1KE2 YDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQPAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 YDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQPAL 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 pF1KE2 FLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSYLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 FLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSYLI 1630 1640 1650 1660 1670 1680 1690 1700 1710 1720 1730 1740 pF1KE2 HAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLARP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 HAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLARP 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 pF1KE2 LPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF :::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF 1750 1760 1770 1780 >>XP_016872071 (OMIM: 604126) PREDICTED: supervillin iso (1873 aa) initn: 11832 init1: 11832 opt: 11832 Z-score: 9254.0 bits: 1725.6 E(85289): 0 Smith-Waterman score: 11832; 100.0% identity (100.0% similar) in 1788 aa overlap (1-1788:86-1873) 10 20 30 pF1KE2 MKRKERIARRLEGIENDTQPILLQSCTGLV :::::::::::::::::::::::::::::: XP_016 RGIDAQLLVALPKVAELRQIFEPKKKEFLEMKRKERIARRLEGIENDTQPILLQSCTGLV 60 70 80 90 100 110 40 50 60 70 80 90 pF1KE2 THRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 THRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGS 120 130 140 150 160 170 100 110 120 130 140 150 pF1KE2 GTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRG 180 190 200 210 220 230 160 170 180 190 200 210 pF1KE2 GKSDKQEESSRDASSLYPGTETMGLRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKSDKQEESSRDASSLYPGTETMGLRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQE 240 250 260 270 280 290 220 230 240 250 260 270 pF1KE2 LSATRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSATRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLS 300 310 320 330 340 350 280 290 300 310 320 330 pF1KE2 PEARPRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEARPRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE 360 370 380 390 400 410 340 350 360 370 380 390 pF1KE2 QRLRRLQDRSLTQPITTEEVVIAATLQASAHQKALAKDQTNEGKELAEQGEPDSSTLSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QRLRRLQDRSLTQPITTEEVVIAATLQASAHQKALAKDQTNEGKELAEQGEPDSSTLSLA 420 430 440 450 460 470 400 410 420 430 440 450 pF1KE2 EKLALFNKLSQPVSKAISTRNRIDTRQRRMNARYQTQPVTLGEVEQVQSGKLIPFSPAVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKLALFNKLSQPVSKAISTRNRIDTRQRRMNARYQTQPVTLGEVEQVQSGKLIPFSPAVN 480 490 500 510 520 530 460 470 480 490 500 510 pF1KE2 TSVSTVASTVAPMYAGDLRTKPPLDHNASATDYKFSSSIENSDSPVRSILKSQAWQPLVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSVSTVASTVAPMYAGDLRTKPPLDHNASATDYKFSSSIENSDSPVRSILKSQAWQPLVE 540 550 560 570 580 590 520 530 540 550 560 570 pF1KE2 GSENKGMLREYGETESKRALTGRDSGMEKYGSFEEAEASYPILNRAREGDSHKESKYAVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSENKGMLREYGETESKRALTGRDSGMEKYGSFEEAEASYPILNRAREGDSHKESKYAVP 600 610 620 630 640 650 580 590 600 610 620 630 pF1KE2 RRGSLERANPPITHLGDEPKEFSMAKMNAQGNLDLRDRLPFEEKVEVENVMKRKFSLRAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRGSLERANPPITHLGDEPKEFSMAKMNAQGNLDLRDRLPFEEKVEVENVMKRKFSLRAA 660 670 680 690 700 710 640 650 660 670 680 690 pF1KE2 EFGEPTSEQTGTAAGKTIAQTTAPVSWKPQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EFGEPTSEQTGTAAGKTIAQTTAPVSWKPQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEG 720 730 740 750 760 770 700 710 720 730 740 750 pF1KE2 LLDSPSKTMSIKERLALLKKSGEEDWRNRLSRRQEGGKAPASSLHTQEAGRSLIKKRVTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLDSPSKTMSIKERLALLKKSGEEDWRNRLSRRQEGGKAPASSLHTQEAGRSLIKKRVTE 780 790 800 810 820 830 760 770 780 790 800 810 pF1KE2 SRESQMTIEERKQLITVREEAWKTRGRGAANDSTQFTVAGRMVKKGLASPTAITPVASPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRESQMTIEERKQLITVREEAWKTRGRGAANDSTQFTVAGRMVKKGLASPTAITPVASPI 840 850 860 870 880 890 820 830 840 850 860 870 pF1KE2 CGKTRGTTPVSKPLEDIEARPDMQLESDLKLDRLETFLRRLNNKVGGMHETVLTVTGKSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CGKTRGTTPVSKPLEDIEARPDMQLESDLKLDRLETFLRRLNNKVGGMHETVLTVTGKSV 900 910 920 930 940 950 880 890 900 910 920 930 pF1KE2 KEVMKPDDDETFAKFYRSVDYNMPRSPVEMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KEVMKPDDDETFAKFYRSVDYNMPRSPVEMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKR 960 970 980 990 1000 1010 940 950 960 970 980 990 pF1KE2 RVQASKNPLKMLAAREDLLQEYTEQRLNVAFMESKRMKVEKMSSNSNFSEVTLAGLASKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RVQASKNPLKMLAAREDLLQEYTEQRLNVAFMESKRMKVEKMSSNSNFSEVTLAGLASKE 1020 1030 1040 1050 1060 1070 1000 1010 1020 1030 1040 1050 pF1KE2 NFSNVSLRSVNLTEQNSNNSAVPYKRLMLLQIKGRRHVQTRLVEPRASALNSGDCFLLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NFSNVSLRSVNLTEQNSNNSAVPYKRLMLLQIKGRRHVQTRLVEPRASALNSGDCFLLLS 1080 1090 1100 1110 1120 1130 1060 1070 1080 1090 1100 1110 pF1KE2 PHCCFLWVGEFANVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFWKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PHCCFLWVGEFANVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFWKL 1140 1150 1160 1170 1180 1190 1120 1130 1140 1150 1160 1170 pF1KE2 LGGQTSYQSAGDPKEDELYEAAIIETNCIYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGGQTSYQSAGDPKEDELYEAAIIETNCIYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLV 1200 1210 1220 1230 1240 1250 1180 1190 1200 1210 1220 1230 pF1KE2 FDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKGQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKGQG 1260 1270 1280 1290 1300 1310 1240 1250 1260 1270 1280 1290 pF1KE2 RPDWAIFGRLTEHNETILFKEKFLDWTELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RPDWAIFGRLTEHNETILFKEKFLDWTELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMV 1320 1330 1340 1350 1360 1370 1300 1310 1320 1330 1340 1350 pF1KE2 SMPQTTAGTILDGVNVGRGYGLVEGHDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SMPQTTAGTILDGVNVGRGYGLVEGHDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFH 1380 1390 1400 1410 1420 1430 1360 1370 1380 1390 1400 1410 pF1KE2 EGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVYFFWQGRHSTVSEKGTSALMTVEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVYFFWQGRHSTVSEKGTSALMTVEL 1440 1450 1460 1470 1480 1490 1420 1430 1440 1450 1460 1470 pF1KE2 DEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRGEVPVEGNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRGEVPVEGNL 1500 1510 1520 1530 1540 1550 1480 1490 1500 1510 1520 1530 pF1KE2 LEVACHCSSLRSRTSMVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEVACHCSSLRSRTSMVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLH 1560 1570 1580 1590 1600 1610 1540 1550 1560 1570 1580 1590 pF1KE2 SSSKVTIHECDEGSEPLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSSKVTIHECDEGSEPLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAAT 1620 1630 1640 1650 1660 1670 1600 1610 1620 1630 1640 1650 pF1KE2 EFVYPARAPSVVSSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EFVYPARAPSVVSSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRW 1680 1690 1700 1710 1720 1730 1660 1670 1680 1690 1700 1710 pF1KE2 ASDRKSAMETVLQYCKGKNLKKPAPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEMDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASDRKSAMETVLQYCKGKNLKKPAPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEMDT 1740 1750 1760 1770 1780 1790 1720 1730 1740 1750 1760 1770 pF1KE2 EVSNQITLVEDVLAKLCKTIYPLADLLARPLPEGVDPLKLEIYLTDEDFEFALDMTRDEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EVSNQITLVEDVLAKLCKTIYPLADLLARPLPEGVDPLKLEIYLTDEDFEFALDMTRDEY 1800 1810 1820 1830 1840 1850 1780 pF1KE2 NALPAWKQVNLKKAKGLF :::::::::::::::::: XP_016 NALPAWKQVNLKKAKGLF 1860 1870 >>XP_011517935 (OMIM: 604126) PREDICTED: supervillin iso (2267 aa) initn: 10036 init1: 10036 opt: 10042 Z-score: 7853.9 bits: 1466.8 E(85289): 0 Smith-Waterman score: 10042; 98.3% identity (98.8% similar) in 1548 aa overlap (244-1788:722-2267) 220 230 240 250 260 270 pF1KE2 TRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSF-GDPQLSPE :.:.. : . .. . : : .: : : XP_011 ACRRPELKSRVERSAEGPGLPTGVERERGSRKPRRYFSPG--ESRKTSERFRTQPITSAE 700 710 720 730 740 280 290 300 310 320 330 pF1KE2 ARP--RCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE . ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKESDRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE 750 760 770 780 790 800 340 350 360 370 380 390 pF1KE2 QRLRRLQDRSLTQPITTEEVVIAATLQASAHQKALAKDQTNEGKELAEQGEPDSSTLSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QRLRRLQDRSLTQPITTEEVVIAATLQASAHQKALAKDQTNEGKELAEQGEPDSSTLSLA 810 820 830 840 850 860 400 410 420 430 440 450 pF1KE2 EKLALFNKLSQPVSKAISTRNRIDTRQRRMNARYQTQPVTLGEVEQVQSGKLIPFSPAVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKLALFNKLSQPVSKAISTRNRIDTRQRRMNARYQTQPVTLGEVEQVQSGKLIPFSPAVN 870 880 890 900 910 920 460 470 480 490 500 510 pF1KE2 TSVSTVASTVAPMYAGDLRTKPPLDHNASATDYKFSSSIENSDSPVRSILKSQAWQPLVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSVSTVASTVAPMYAGDLRTKPPLDHNASATDYKFSSSIENSDSPVRSILKSQAWQPLVE 930 940 950 960 970 980 520 530 540 550 560 570 pF1KE2 GSENKGMLREYGETESKRALTGRDSGMEKYGSFEEAEASYPILNRAREGDSHKESKYAVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSENKGMLREYGETESKRALTGRDSGMEKYGSFEEAEASYPILNRAREGDSHKESKYAVP 990 1000 1010 1020 1030 1040 580 590 600 610 620 630 pF1KE2 RRGSLERANPPITHLGDEPKEFSMAKMNAQGNLDLRDRLPFEEKVEVENVMKRKFSLRAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRGSLERANPPITHLGDEPKEFSMAKMNAQGNLDLRDRLPFEEKVEVENVMKRKFSLRAA 1050 1060 1070 1080 1090 1100 640 650 660 670 680 690 pF1KE2 EFGEPTSEQTGTAAGKTIAQTTAPVSWKPQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EFGEPTSEQTGTAAGKTIAQTTAPVSWKPQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEG 1110 1120 1130 1140 1150 1160 700 710 720 730 740 750 pF1KE2 LLDSPSKTMSIKERLALLKKSGEEDWRNRLSRRQEGGKAPASSLHTQEAGRSLIKKRVTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLDSPSKTMSIKERLALLKKSGEEDWRNRLSRRQEGGKAPASSLHTQEAGRSLIKKRVTE 1170 1180 1190 1200 1210 1220 760 770 780 790 800 810 pF1KE2 SRESQMTIEERKQLITVREEAWKTRGRGAANDSTQFTVAGRMVKKGLASPTAITPVASPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SRESQMTIEERKQLITVREEAWKTRGRGAANDSTQFTVAGRMVKKGLASPTAITPVASPI 1230 1240 1250 1260 1270 1280 820 830 840 850 860 870 pF1KE2 CGKTRGTTPVSKPLEDIEARPDMQLESDLKLDRLETFLRRLNNKVGGMHETVLTVTGKSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CGKTRGTTPVSKPLEDIEARPDMQLESDLKLDRLETFLRRLNNKVGGMHETVLTVTGKSV 1290 1300 1310 1320 1330 1340 880 890 900 910 920 930 pF1KE2 KEVMKPDDDETFAKFYRSVDYNMPRSPVEMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KEVMKPDDDETFAKFYRSVDYNMPRSPVEMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKR 1350 1360 1370 1380 1390 1400 940 950 960 970 980 990 pF1KE2 RVQASKNPLKMLAAREDLLQEYTEQRLNVAFMESKRMKVEKMSSNSNFSEVTLAGLASKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RVQASKNPLKMLAAREDLLQEYTEQRLNVAFMESKRMKVEKMSSNSNFSEVTLAGLASKE 1410 1420 1430 1440 1450 1460 1000 1010 1020 1030 1040 1050 pF1KE2 NFSNVSLRSVNLTEQNSNNSAVPYKRLMLLQIKGRRHVQTRLVEPRASALNSGDCFLLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NFSNVSLRSVNLTEQNSNNSAVPYKRLMLLQIKGRRHVQTRLVEPRASALNSGDCFLLLS 1470 1480 1490 1500 1510 1520 1060 1070 1080 1090 1100 1110 pF1KE2 PHCCFLWVGEFANVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFWKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PHCCFLWVGEFANVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFWKL 1530 1540 1550 1560 1570 1580 1120 1130 1140 1150 1160 1170 pF1KE2 LGGQTSYQSAGDPKEDELYEAAIIETNCIYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGGQTSYQSAGDPKEDELYEAAIIETNCIYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLV 1590 1600 1610 1620 1630 1640 1180 1190 1200 1210 1220 1230 pF1KE2 FDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKGQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKGQG 1650 1660 1670 1680 1690 1700 1240 1250 1260 1270 1280 1290 pF1KE2 RPDWAIFGRLTEHNETILFKEKFLDWTELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RPDWAIFGRLTEHNETILFKEKFLDWTELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMV 1710 1720 1730 1740 1750 1760 1300 1310 1320 1330 1340 1350 pF1KE2 SMPQTTAGTILDGVNVGRGYGLVEGHDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SMPQTTAGTILDGVNVGRGYGLVEGHDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFH 1770 1780 1790 1800 1810 1820 1360 1370 1380 1390 1400 1410 pF1KE2 EGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVYFFWQGRHSTVSEKGTSALMTVEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVYFFWQGRHSTVSEKGTSALMTVEL 1830 1840 1850 1860 1870 1880 1420 1430 1440 1450 1460 1470 pF1KE2 DEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRGEVPVEGNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRGEVPVEGNL 1890 1900 1910 1920 1930 1940 1480 1490 1500 1510 1520 1530 pF1KE2 LEVACHCSSLRSRTSMVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LEVACHCSSLRSRTSMVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLH 1950 1960 1970 1980 1990 2000 1540 1550 1560 1570 1580 1590 pF1KE2 SSSKVTIHECDEGSEPLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSSKVTIHECDEGSEPLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAAT 2010 2020 2030 2040 2050 2060 1600 1610 1620 1630 1640 1650 pF1KE2 EFVYPARAPSVVSSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EFVYPARAPSVVSSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRW 2070 2080 2090 2100 2110 2120 1660 1670 1680 1690 1700 1710 pF1KE2 ASDRKSAMETVLQYCKGKNLKKPAPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEMDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASDRKSAMETVLQYCKGKNLKKPAPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEMDT 2130 2140 2150 2160 2170 2180 1720 1730 1740 1750 1760 1770 pF1KE2 EVSNQITLVEDVLAKLCKTIYPLADLLARPLPEGVDPLKLEIYLTDEDFEFALDMTRDEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVSNQITLVEDVLAKLCKTIYPLADLLARPLPEGVDPLKLEIYLTDEDFEFALDMTRDEY 2190 2200 2210 2220 2230 2240 1780 pF1KE2 NALPAWKQVNLKKAKGLF :::::::::::::::::: XP_011 NALPAWKQVNLKKAKGLF 2250 2260 >-- initn: 1828 init1: 1798 opt: 1802 Z-score: 1413.6 bits: 275.1 E(85289): 5.4e-72 Smith-Waterman score: 1802; 85.2% identity (91.6% similar) in 332 aa overlap (1-332:86-415) 10 20 30 pF1KE2 MKRKERIARRLEGIENDTQPILLQSCTGLV :::::::::::::::::::::::::::::: XP_011 RGIDAQLLVALPKVAELRQIFEPKKKEFLEMKRKERIARRLEGIENDTQPILLQSCTGLV 60 70 80 90 100 110 40 50 60 70 80 90 pF1KE2 THRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 THRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGS 120 130 140 150 160 170 100 110 120 130 140 150 pF1KE2 GTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRG 180 190 200 210 220 230 160 170 180 190 200 210 pF1KE2 GKSDKQEESSRDASSLYPGTETMGLRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GKSDKQEESSRDASSLYPGTETMGLRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQE 240 250 260 270 280 290 220 230 240 250 260 270 pF1KE2 LSATRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSATRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLS 300 310 320 330 340 350 280 290 300 310 320 330 pF1KE2 PEARPRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE ::::: . .. .. . . : . .. .. . ... : . .: :. :.. : XP_011 PEARPSTGKPKHEWFLQKDSEGDTPSLINWPSRVKVREKLVKEESARNSPELASES--VT 360 370 380 390 400 410 340 350 360 370 380 390 pF1KE2 QRLRRLQDRSLTQPITTEEVVIAATLQASAHQKALAKDQTNEGKELAEQGEPDSSTLSLA :: XP_011 QRRHQPAPVHYVSFQSEHSAFDRVPSKAAGSTRQPIRGYVQPADTGHTAKLVTPETPENA 420 430 440 450 460 470 >>NP_001310529 (OMIM: 604126) supervillin isoform 4 [Hom (1820 aa) initn: 9553 init1: 9553 opt: 9584 Z-score: 7497.2 bits: 1400.4 E(85289): 0 Smith-Waterman score: 11758; 98.2% identity (98.2% similar) in 1820 aa overlap (1-1788:1-1820) 10 20 30 40 50 60 pF1KE2 MKRKERIARRLEGIENDTQPILLQSCTGLVTHRLLEEDTPRYMRASDPASPHIGRSNEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKRKERIARRLEGIENDTQPILLQSCTGLVTHRLLEEDTPRYMRASDPASPHIGRSNEEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRRQLAEKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRRQLAEKY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 GLTLDPEADSEYLSRYTKSRKEPDAVEKRGGKSDKQEESSRDASSLYPGTETMGLRTCAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLTLDPEADSEYLSRYTKSRKEPDAVEKRGGKSDKQEESSRDASSLYPGTETMGLRTCAG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 ESKDYALHVGDGSSDPEVLLNIENQRRGQELSATRQAHDLSPAAESSSTFSFSGRDSSFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESKDYALHVGDGSSDPEVLLNIENQRRGQELSATRQAHDLSPAAESSSTFSFSGRDSSFT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 EVPRSPKHAHSSSLQQAASRSPSFGDPQLSPEARPRCTSHSETPTVDDEEKVDERAKLSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVPRSPKHAHSSSLQQAASRSPSFGDPQLSPEARPRCTSHSETPTVDDEEKVDERAKLSV 250 260 270 280 290 300 310 320 330 340 350 pF1KE2 AAKRLLFREMEKSFDEQNVPKRRSRNTAVEQRLRRLQDRSLTQPITTEEVVIAAT----- ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAKRLLFREMEKSFDEQNVPKRRSRNTAVEQRLRRLQDRSLTQPITTEEVVIAATEPIPA 310 320 330 340 350 360 360 370 380 pF1KE2 ---------------------------LQASAHQKALAKDQTNEGKELAEQGEPDSSTLS ::::::::::::::::::::::::::::::::: NP_001 SCSGGTHPVMARLPSPTVARSAVQPARLQASAHQKALAKDQTNEGKELAEQGEPDSSTLS 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE2 LAEKLALFNKLSQPVSKAISTRNRIDTRQRRMNARYQTQPVTLGEVEQVQSGKLIPFSPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAEKLALFNKLSQPVSKAISTRNRIDTRQRRMNARYQTQPVTLGEVEQVQSGKLIPFSPA 430 440 450 460 470 480 450 460 470 480 490 500 pF1KE2 VNTSVSTVASTVAPMYAGDLRTKPPLDHNASATDYKFSSSIENSDSPVRSILKSQAWQPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VNTSVSTVASTVAPMYAGDLRTKPPLDHNASATDYKFSSSIENSDSPVRSILKSQAWQPL 490 500 510 520 530 540 510 520 530 540 550 560 pF1KE2 VEGSENKGMLREYGETESKRALTGRDSGMEKYGSFEEAEASYPILNRAREGDSHKESKYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEGSENKGMLREYGETESKRALTGRDSGMEKYGSFEEAEASYPILNRAREGDSHKESKYA 550 560 570 580 590 600 570 580 590 600 610 620 pF1KE2 VPRRGSLERANPPITHLGDEPKEFSMAKMNAQGNLDLRDRLPFEEKVEVENVMKRKFSLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPRRGSLERANPPITHLGDEPKEFSMAKMNAQGNLDLRDRLPFEEKVEVENVMKRKFSLR 610 620 630 640 650 660 630 640 650 660 670 680 pF1KE2 AAEFGEPTSEQTGTAAGKTIAQTTAPVSWKPQDSSEQPQEKLCKNPCAMFAAGEIKTPTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAEFGEPTSEQTGTAAGKTIAQTTAPVSWKPQDSSEQPQEKLCKNPCAMFAAGEIKTPTG 670 680 690 700 710 720 690 700 710 720 730 740 pF1KE2 EGLLDSPSKTMSIKERLALLKKSGEEDWRNRLSRRQEGGKAPASSLHTQEAGRSLIKKRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGLLDSPSKTMSIKERLALLKKSGEEDWRNRLSRRQEGGKAPASSLHTQEAGRSLIKKRV 730 740 750 760 770 780 750 760 770 780 790 800 pF1KE2 TESRESQMTIEERKQLITVREEAWKTRGRGAANDSTQFTVAGRMVKKGLASPTAITPVAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TESRESQMTIEERKQLITVREEAWKTRGRGAANDSTQFTVAGRMVKKGLASPTAITPVAS 790 800 810 820 830 840 810 820 830 840 850 860 pF1KE2 PICGKTRGTTPVSKPLEDIEARPDMQLESDLKLDRLETFLRRLNNKVGGMHETVLTVTGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PICGKTRGTTPVSKPLEDIEARPDMQLESDLKLDRLETFLRRLNNKVGGMHETVLTVTGK 850 860 870 880 890 900 870 880 890 900 910 920 pF1KE2 SVKEVMKPDDDETFAKFYRSVDYNMPRSPVEMDEDFDVIFDPYAPKLTSSVAEHKRAVRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVKEVMKPDDDETFAKFYRSVDYNMPRSPVEMDEDFDVIFDPYAPKLTSSVAEHKRAVRP 910 920 930 940 950 960 930 940 950 960 970 980 pF1KE2 KRRVQASKNPLKMLAAREDLLQEYTEQRLNVAFMESKRMKVEKMSSNSNFSEVTLAGLAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRRVQASKNPLKMLAAREDLLQEYTEQRLNVAFMESKRMKVEKMSSNSNFSEVTLAGLAS 970 980 990 1000 1010 1020 990 1000 1010 1020 1030 1040 pF1KE2 KENFSNVSLRSVNLTEQNSNNSAVPYKRLMLLQIKGRRHVQTRLVEPRASALNSGDCFLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KENFSNVSLRSVNLTEQNSNNSAVPYKRLMLLQIKGRRHVQTRLVEPRASALNSGDCFLL 1030 1040 1050 1060 1070 1080 1050 1060 1070 1080 1090 1100 pF1KE2 LSPHCCFLWVGEFANVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSPHCCFLWVGEFANVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFW 1090 1100 1110 1120 1130 1140 1110 1120 1130 1140 1150 1160 pF1KE2 KLLGGQTSYQSAGDPKEDELYEAAIIETNCIYRLMDDKLVPDDDYWGKIPKCSLLQPKEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLLGGQTSYQSAGDPKEDELYEAAIIETNCIYRLMDDKLVPDDDYWGKIPKCSLLQPKEV 1150 1160 1170 1180 1190 1200 1170 1180 1190 1200 1210 1220 pF1KE2 LVFDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVFDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKG 1210 1220 1230 1240 1250 1260 1230 1240 1250 1260 1270 1280 pF1KE2 QGRPDWAIFGRLTEHNETILFKEKFLDWTELKRSNEKNPGELAQHKEDPRTDVKAYDVTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QGRPDWAIFGRLTEHNETILFKEKFLDWTELKRSNEKNPGELAQHKEDPRTDVKAYDVTR 1270 1280 1290 1300 1310 1320 1290 1300 1310 1320 1330 1340 pF1KE2 MVSMPQTTAGTILDGVNVGRGYGLVEGHDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVSMPQTTAGTILDGVNVGRGYGLVEGHDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQ 1330 1340 1350 1360 1370 1380 1350 1360 1370 1380 1390 1400 pF1KE2 FHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVYFFWQGRHSTVSEKGTSALMTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVYFFWQGRHSTVSEKGTSALMTV 1390 1400 1410 1420 1430 1440 1410 1420 1430 1440 1450 1460 pF1KE2 ELDEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRGEVPVEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELDEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRGEVPVEG 1450 1460 1470 1480 1490 1500 1470 1480 1490 1500 1510 1520 pF1KE2 NLLEVACHCSSLRSRTSMVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NLLEVACHCSSLRSRTSMVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAG 1510 1520 1530 1540 1550 1560 1530 1540 1550 1560 1570 1580 pF1KE2 LHSSSKVTIHECDEGSEPLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHSSSKVTIHECDEGSEPLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFA 1570 1580 1590 1600 1610 1620 1590 1600 1610 1620 1630 1640 pF1KE2 ATEFVYPARAPSVVSSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATEFVYPARAPSVVSSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARI 1630 1640 1650 1660 1670 1680 1650 1660 1670 1680 1690 1700 pF1KE2 RWASDRKSAMETVLQYCKGKNLKKPAPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RWASDRKSAMETVLQYCKGKNLKKPAPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEM 1690 1700 1710 1720 1730 1740 1710 1720 1730 1740 1750 1760 pF1KE2 DTEVSNQITLVEDVLAKLCKTIYPLADLLARPLPEGVDPLKLEIYLTDEDFEFALDMTRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTEVSNQITLVEDVLAKLCKTIYPLADLLARPLPEGVDPLKLEIYLTDEDFEFALDMTRD 1750 1760 1770 1780 1790 1800 1770 1780 pF1KE2 EYNALPAWKQVNLKKAKGLF :::::::::::::::::::: NP_001 EYNALPAWKQVNLKKAKGLF 1810 1820 >>XP_016872070 (OMIM: 604126) PREDICTED: supervillin iso (1905 aa) initn: 9553 init1: 9553 opt: 9584 Z-score: 7496.9 bits: 1400.5 E(85289): 0 Smith-Waterman score: 11758; 98.2% identity (98.2% similar) in 1820 aa overlap (1-1788:86-1905) 10 20 30 pF1KE2 MKRKERIARRLEGIENDTQPILLQSCTGLV :::::::::::::::::::::::::::::: XP_016 RGIDAQLLVALPKVAELRQIFEPKKKEFLEMKRKERIARRLEGIENDTQPILLQSCTGLV 60 70 80 90 100 110 40 50 60 70 80 90 pF1KE2 THRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 THRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGS 120 130 140 150 160 170 100 110 120 130 140 150 pF1KE2 GTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRG 180 190 200 210 220 230 160 170 180 190 200 210 pF1KE2 GKSDKQEESSRDASSLYPGTETMGLRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKSDKQEESSRDASSLYPGTETMGLRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQE 240 250 260 270 280 290 220 230 240 250 260 270 pF1KE2 LSATRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSATRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLS 300 310 320 330 340 350 280 290 300 310 320 330 pF1KE2 PEARPRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEARPRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE 360 370 380 390 400 410 340 350 pF1KE2 QRLRRLQDRSLTQPITTEEVVIAAT--------------------------------LQA ::::::::::::::::::::::::: ::: XP_016 QRLRRLQDRSLTQPITTEEVVIAATEPIPASCSGGTHPVMARLPSPTVARSAVQPARLQA 420 430 440 450 460 470 360 370 380 390 400 410 pF1KE2 SAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQR 480 490 500 510 520 530 420 430 440 450 460 470 pF1KE2 RMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNA 540 550 560 570 580 590 480 490 500 510 520 530 pF1KE2 SATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGME 600 610 620 630 640 650 540 550 560 570 580 590 pF1KE2 KYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMN 660 670 680 690 700 710 600 610 620 630 640 650 pF1KE2 AQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWK 720 730 740 750 760 770 660 670 680 690 700 710 pF1KE2 PQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRN 780 790 800 810 820 830 720 730 740 750 760 770 pF1KE2 RLSRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLSRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRG 840 850 860 870 880 890 780 790 800 810 820 830 pF1KE2 AANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESD 900 910 920 930 940 950 840 850 860 870 880 890 pF1KE2 LKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPV 960 970 980 990 1000 1010 900 910 920 930 940 950 pF1KE2 EMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLN 1020 1030 1040 1050 1060 1070 960 970 980 990 1000 1010 pF1KE2 VAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLM 1080 1090 1100 1110 1120 1130 1020 1030 1040 1050 1060 1070 pF1KE2 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ 1140 1150 1160 1170 1180 1190 1080 1090 1100 1110 1120 1130 pF1KE2 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC 1200 1210 1220 1230 1240 1250 1140 1150 1160 1170 1180 1190 pF1KE2 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAK 1260 1270 1280 1290 1300 1310 1200 1210 1220 1230 1240 1250 pF1KE2 HLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTE 1320 1330 1340 1350 1360 1370 1260 1270 1280 1290 1300 1310 pF1KE2 LKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDR 1380 1390 1400 1410 1420 1430 1320 1330 1340 1350 1360 1370 pF1KE2 RQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVR 1440 1450 1460 1470 1480 1490 1380 1390 1400 1410 1420 1430 pF1KE2 AAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMV 1500 1510 1520 1530 1540 1550 1440 1450 1460 1470 1480 1490 pF1KE2 VHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYL 1560 1570 1580 1590 1600 1610 1500 1510 1520 1530 1540 1550 pF1KE2 WHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDR 1620 1630 1640 1650 1660 1670 1560 1570 1580 1590 1600 1610 pF1KE2 KAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQP 1680 1690 1700 1710 1720 1730 1620 1630 1640 1650 1660 1670 pF1KE2 ALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSY 1740 1750 1760 1770 1780 1790 1680 1690 1700 1710 1720 1730 pF1KE2 LIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLA 1800 1810 1820 1830 1840 1850 1740 1750 1760 1770 1780 pF1KE2 RPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF :::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF 1860 1870 1880 1890 1900 >>NP_001310528 (OMIM: 604126) supervillin isoform 3 [Hom (1904 aa) initn: 9553 init1: 9553 opt: 9557 Z-score: 7475.8 bits: 1396.6 E(85289): 0 Smith-Waterman score: 11029; 93.6% identity (93.6% similar) in 1820 aa overlap (85-1788:85-1904) 60 70 80 90 100 110 pF1KE2 RSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRR :::::::::::::::::::::::::::::: NP_001 RSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRR 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 QLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRGGKSDKQEESSRDASSLYPGTETMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRGGKSDKQEESSRDASSLYPGTETMG 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 LRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQELSATRQAHDLSPAAESSSTFSFSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQELSATRQAHDLSPAAESSSTFSFSG 180 190 200 210 220 230 240 250 260 270 pF1KE2 RDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLSPEARP------------------- ::::::::::::::::::::::::::::::::::::::::: NP_001 RDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLSPEARPSTGKPKHEWFLQKDSEGDT 240 250 260 270 280 290 pF1KE2 ------------------------------------------------------------ NP_001 PSLINWPSSKSRVERSAEGPGLPTGVERERGSRKPRRYFSPGESRKTSERFRTQPITSAE 300 310 320 330 340 350 280 290 300 310 320 330 pF1KE2 -----RCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKESDRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE 360 370 380 390 400 410 340 350 pF1KE2 QRLRRLQDRSLTQPITTEEVVIAAT--------------------------------LQA ::::::::::::::::::::::::: ::: NP_001 QRLRRLQDRSLTQPITTEEVVIAATEPIPASCSGGTHPVMARLPSPTVARSAVQPARLQA 420 430 440 450 460 470 360 370 380 390 400 410 pF1KE2 SAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQR 480 490 500 510 520 530 420 430 440 450 460 470 pF1KE2 RMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNA 540 550 560 570 580 590 480 490 500 510 520 530 pF1KE2 SATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGME 600 610 620 630 640 650 540 550 560 570 580 590 pF1KE2 KYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMN 660 670 680 690 700 710 600 610 620 630 640 650 pF1KE2 AQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWK 720 730 740 750 760 770 660 670 680 690 700 710 pF1KE2 PQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRN 780 790 800 810 820 830 720 730 740 750 760 770 pF1KE2 RLSRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLSRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRG 840 850 860 870 880 890 780 790 800 810 820 830 pF1KE2 AANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESD 900 910 920 930 940 950 840 850 860 870 880 890 pF1KE2 LKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPV 960 970 980 990 1000 1010 900 910 920 930 940 950 pF1KE2 EMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLN 1020 1030 1040 1050 1060 1070 960 970 980 990 1000 1010 pF1KE2 VAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLM 1080 1090 1100 1110 1120 1130 1020 1030 1040 1050 1060 1070 pF1KE2 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ 1140 1150 1160 1170 1180 1190 1080 1090 1100 1110 1120 1130 pF1KE2 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC 1200 1210 1220 1230 1240 1250 1140 1150 1160 1170 1180 1190 pF1KE2 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAK 1260 1270 1280 1290 1300 1310 1200 1210 1220 1230 1240 1250 pF1KE2 HLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTE 1320 1330 1340 1350 1360 1370 1260 1270 1280 1290 1300 1310 pF1KE2 LKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDR 1380 1390 1400 1410 1420 1430 1320 1330 1340 1350 1360 1370 pF1KE2 RQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVR 1440 1450 1460 1470 1480 1490 1380 1390 1400 1410 1420 1430 pF1KE2 AAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMV 1500 1510 1520 1530 1540 1550 1440 1450 1460 1470 1480 1490 pF1KE2 VHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYL 1560 1570 1580 1590 1600 1610 1500 1510 1520 1530 1540 1550 pF1KE2 WHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDR 1620 1630 1640 1650 1660 1670 1560 1570 1580 1590 1600 1610 pF1KE2 KAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQP 1680 1690 1700 1710 1720 1730 1620 1630 1640 1650 1660 1670 pF1KE2 ALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSY 1740 1750 1760 1770 1780 1790 1680 1690 1700 1710 1720 1730 pF1KE2 LIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLA 1800 1810 1820 1830 1840 1850 1740 1750 1760 1770 1780 pF1KE2 RPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF 1860 1870 1880 1890 1900 >-- initn: 551 init1: 551 opt: 551 Z-score: 436.8 bits: 94.1 E(85289): 1.4e-17 Smith-Waterman score: 551; 100.0% identity (100.0% similar) in 84 aa overlap (1-84:1-84) 10 20 30 40 50 60 pF1KE2 MKRKERIARRLEGIENDTQPILLQSCTGLVTHRLLEEDTPRYMRASDPASPHIGRSNEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKRKERIARRLEGIENDTQPILLQSCTGLVTHRLLEEDTPRYMRASDPASPHIGRSNEEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRRQLAEKY :::::::::::::::::::::::: NP_001 ETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRRQLAEKY 70 80 90 100 110 120 >>XP_016872068 (OMIM: 604126) PREDICTED: supervillin iso (1989 aa) initn: 9553 init1: 9553 opt: 9557 Z-score: 7475.6 bits: 1396.6 E(85289): 0 Smith-Waterman score: 11029; 93.6% identity (93.6% similar) in 1820 aa overlap (85-1788:170-1989) 60 70 80 90 100 110 pF1KE2 RSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRR :::::::::::::::::::::::::::::: XP_016 RSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRR 140 150 160 170 180 190 120 130 140 150 160 170 pF1KE2 QLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRGGKSDKQEESSRDASSLYPGTETMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRGGKSDKQEESSRDASSLYPGTETMG 200 210 220 230 240 250 180 190 200 210 220 230 pF1KE2 LRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQELSATRQAHDLSPAAESSSTFSFSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQELSATRQAHDLSPAAESSSTFSFSG 260 270 280 290 300 310 240 250 260 270 pF1KE2 RDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLSPEARP------------------- ::::::::::::::::::::::::::::::::::::::::: XP_016 RDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLSPEARPSTGKPKHEWFLQKDSEGDT 320 330 340 350 360 370 pF1KE2 ------------------------------------------------------------ XP_016 PSLINWPSSKSRVERSAEGPGLPTGVERERGSRKPRRYFSPGESRKTSERFRTQPITSAE 380 390 400 410 420 430 280 290 300 310 320 330 pF1KE2 -----RCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKESDRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE 440 450 460 470 480 490 340 350 pF1KE2 QRLRRLQDRSLTQPITTEEVVIAAT--------------------------------LQA ::::::::::::::::::::::::: ::: XP_016 QRLRRLQDRSLTQPITTEEVVIAATEPIPASCSGGTHPVMARLPSPTVARSAVQPARLQA 500 510 520 530 540 550 360 370 380 390 400 410 pF1KE2 SAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQR 560 570 580 590 600 610 420 430 440 450 460 470 pF1KE2 RMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNA 620 630 640 650 660 670 480 490 500 510 520 530 pF1KE2 SATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGME 680 690 700 710 720 730 540 550 560 570 580 590 pF1KE2 KYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMN 740 750 760 770 780 790 600 610 620 630 640 650 pF1KE2 AQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWK 800 810 820 830 840 850 660 670 680 690 700 710 pF1KE2 PQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRN 860 870 880 890 900 910 720 730 740 750 760 770 pF1KE2 RLSRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLSRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRG 920 930 940 950 960 970 780 790 800 810 820 830 pF1KE2 AANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESD 980 990 1000 1010 1020 1030 840 850 860 870 880 890 pF1KE2 LKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPV 1040 1050 1060 1070 1080 1090 900 910 920 930 940 950 pF1KE2 EMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLN 1100 1110 1120 1130 1140 1150 960 970 980 990 1000 1010 pF1KE2 VAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLM 1160 1170 1180 1190 1200 1210 1020 1030 1040 1050 1060 1070 pF1KE2 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ 1220 1230 1240 1250 1260 1270 1080 1090 1100 1110 1120 1130 pF1KE2 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC 1280 1290 1300 1310 1320 1330 1140 1150 1160 1170 1180 1190 pF1KE2 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAK 1340 1350 1360 1370 1380 1390 1200 1210 1220 1230 1240 1250 pF1KE2 HLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTE 1400 1410 1420 1430 1440 1450 1260 1270 1280 1290 1300 1310 pF1KE2 LKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDR 1460 1470 1480 1490 1500 1510 1320 1330 1340 1350 1360 1370 pF1KE2 RQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVR 1520 1530 1540 1550 1560 1570 1380 1390 1400 1410 1420 1430 pF1KE2 AAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMV 1580 1590 1600 1610 1620 1630 1440 1450 1460 1470 1480 1490 pF1KE2 VHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYL 1640 1650 1660 1670 1680 1690 1500 1510 1520 1530 1540 1550 pF1KE2 WHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDR 1700 1710 1720 1730 1740 1750 1560 1570 1580 1590 1600 1610 pF1KE2 KAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQP 1760 1770 1780 1790 1800 1810 1620 1630 1640 1650 1660 1670 pF1KE2 ALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSY 1820 1830 1840 1850 1860 1870 1680 1690 1700 1710 1720 1730 pF1KE2 LIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLA 1880 1890 1900 1910 1920 1930 1740 1750 1760 1770 1780 pF1KE2 RPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF :::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF 1940 1950 1960 1970 1980 >-- initn: 551 init1: 551 opt: 551 Z-score: 436.5 bits: 94.1 E(85289): 1.4e-17 Smith-Waterman score: 551; 100.0% identity (100.0% similar) in 84 aa overlap (1-84:86-169) 10 20 30 pF1KE2 MKRKERIARRLEGIENDTQPILLQSCTGLV :::::::::::::::::::::::::::::: XP_016 RGIDAQLLVALPKVAELRQIFEPKKKEFLEMKRKERIARRLEGIENDTQPILLQSCTGLV 60 70 80 90 100 110 40 50 60 70 80 90 pF1KE2 THRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGS :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 THRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGS 120 130 140 150 160 170 100 110 120 130 140 150 pF1KE2 GTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRG XP_016 GTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRG 180 190 200 210 220 230 >>NP_068506 (OMIM: 604126) supervillin isoform 2 [Homo s (2214 aa) initn: 11337 init1: 9553 opt: 9557 Z-score: 7475.0 bits: 1396.6 E(85289): 0 Smith-Waterman score: 9968; 96.3% identity (96.8% similar) in 1580 aa overlap (244-1788:637-2214) 220 230 240 250 260 270 pF1KE2 TRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSF-GDPQLSPE :.:.. : . .. . : : .: : : NP_068 ACRRPELKSRVERSAEGPGLPTGVERERGSRKPRRYFSPG--ESRKTSERFRTQPITSAE 610 620 630 640 650 660 280 290 300 310 320 330 pF1KE2 ARP--RCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE . ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 RKESDRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE 670 680 690 700 710 720 340 350 pF1KE2 QRLRRLQDRSLTQPITTEEVVIAAT--------------------------------LQA ::::::::::::::::::::::::: ::: NP_068 QRLRRLQDRSLTQPITTEEVVIAATEPIPASCSGGTHPVMARLPSPTVARSAVQPARLQA 730 740 750 760 770 780 360 370 380 390 400 410 pF1KE2 SAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 SAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQR 790 800 810 820 830 840 420 430 440 450 460 470 pF1KE2 RMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 RMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNA 850 860 870 880 890 900 480 490 500 510 520 530 pF1KE2 SATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 SATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGME 910 920 930 940 950 960 540 550 560 570 580 590 pF1KE2 KYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 KYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMN 970 980 990 1000 1010 1020 600 610 620 630 640 650 pF1KE2 AQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 AQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWK 1030 1040 1050 1060 1070 1080 660 670 680 690 700 710 pF1KE2 PQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 PQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRN 1090 1100 1110 1120 1130 1140 720 730 740 750 760 770 pF1KE2 RLSRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 RLSRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRG 1150 1160 1170 1180 1190 1200 780 790 800 810 820 830 pF1KE2 AANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 AANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESD 1210 1220 1230 1240 1250 1260 840 850 860 870 880 890 pF1KE2 LKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 LKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPV 1270 1280 1290 1300 1310 1320 900 910 920 930 940 950 pF1KE2 EMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 EMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLN 1330 1340 1350 1360 1370 1380 960 970 980 990 1000 1010 pF1KE2 VAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 VAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLM 1390 1400 1410 1420 1430 1440 1020 1030 1040 1050 1060 1070 pF1KE2 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ 1450 1460 1470 1480 1490 1500 1080 1090 1100 1110 1120 1130 pF1KE2 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC 1510 1520 1530 1540 1550 1560 1140 1150 1160 1170 1180 1190 pF1KE2 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAK 1570 1580 1590 1600 1610 1620 1200 1210 1220 1230 1240 1250 pF1KE2 HLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 HLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTE 1630 1640 1650 1660 1670 1680 1260 1270 1280 1290 1300 1310 pF1KE2 LKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 LKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDR 1690 1700 1710 1720 1730 1740 1320 1330 1340 1350 1360 1370 pF1KE2 RQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 RQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVR 1750 1760 1770 1780 1790 1800 1380 1390 1400 1410 1420 1430 pF1KE2 AAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 AAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMV 1810 1820 1830 1840 1850 1860 1440 1450 1460 1470 1480 1490 pF1KE2 VHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 VHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYL 1870 1880 1890 1900 1910 1920 1500 1510 1520 1530 1540 1550 pF1KE2 WHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 WHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDR 1930 1940 1950 1960 1970 1980 1560 1570 1580 1590 1600 1610 pF1KE2 KAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 KAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQP 1990 2000 2010 2020 2030 2040 1620 1630 1640 1650 1660 1670 pF1KE2 ALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 ALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSY 2050 2060 2070 2080 2090 2100 1680 1690 1700 1710 1720 1730 pF1KE2 LIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 LIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLA 2110 2120 2130 2140 2150 2160 1740 1750 1760 1770 1780 pF1KE2 RPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF :::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 RPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF 2170 2180 2190 2200 2210 >-- initn: 1840 init1: 1798 opt: 1802 Z-score: 1413.7 bits: 275.1 E(85289): 5.3e-72 Smith-Waterman score: 1802; 85.2% identity (91.6% similar) in 332 aa overlap (1-332:1-330) 10 20 30 40 50 60 pF1KE2 MKRKERIARRLEGIENDTQPILLQSCTGLVTHRLLEEDTPRYMRASDPASPHIGRSNEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 MKRKERIARRLEGIENDTQPILLQSCTGLVTHRLLEEDTPRYMRASDPASPHIGRSNEEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRRQLAEKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 ETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRRQLAEKY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 GLTLDPEADSEYLSRYTKSRKEPDAVEKRGGKSDKQEESSRDASSLYPGTETMGLRTCAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 GLTLDPEADSEYLSRYTKSRKEPDAVEKRGGKSDKQEESSRDASSLYPGTETMGLRTCAG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 ESKDYALHVGDGSSDPEVLLNIENQRRGQELSATRQAHDLSPAAESSSTFSFSGRDSSFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 ESKDYALHVGDGSSDPEVLLNIENQRRGQELSATRQAHDLSPAAESSSTFSFSGRDSSFT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 EVPRSPKHAHSSSLQQAASRSPSFGDPQLSPEARPRCTSHSETPTVDDEEKVDERAKLSV ::::::::::::::::::::::::::::::::::: . .. .. . . : . .. NP_068 EVPRSPKHAHSSSLQQAASRSPSFGDPQLSPEARPSTGKPKHEWFLQKDSEGDTPSLINW 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 AAKRLLFREMEKSFDEQNVPKRRSRNTAVEQRLRRLQDRSLTQPITTEEVVIAATLQASA .. . ... : . .: :. :.. : :: NP_068 PSRVKVREKLVKEESARNSPELASES--VTQRRHQPAPVHYVSFQSEHSAFDRVPSKAAG 310 320 330 340 350 370 380 390 400 410 420 pF1KE2 HQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQRRM NP_068 STRQPIRGYVQPADTGHTAKLVTPETPENASECSWVASATQNVPKPPSLTVLEGDGRDSP 360 370 380 390 400 410 >>XP_016872066 (OMIM: 604126) PREDICTED: supervillin iso (2299 aa) initn: 11337 init1: 9553 opt: 9557 Z-score: 7474.7 bits: 1396.6 E(85289): 0 Smith-Waterman score: 9968; 96.3% identity (96.8% similar) in 1580 aa overlap (244-1788:722-2299) 220 230 240 250 260 270 pF1KE2 TRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSF-GDPQLSPE :.:.. : . .. . : : .: : : XP_016 ACRRPELKSRVERSAEGPGLPTGVERERGSRKPRRYFSPG--ESRKTSERFRTQPITSAE 700 710 720 730 740 280 290 300 310 320 330 pF1KE2 ARP--RCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE . ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKESDRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE 750 760 770 780 790 800 340 350 pF1KE2 QRLRRLQDRSLTQPITTEEVVIAAT--------------------------------LQA ::::::::::::::::::::::::: ::: XP_016 QRLRRLQDRSLTQPITTEEVVIAATEPIPASCSGGTHPVMARLPSPTVARSAVQPARLQA 810 820 830 840 850 860 360 370 380 390 400 410 pF1KE2 SAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQR 870 880 890 900 910 920 420 430 440 450 460 470 pF1KE2 RMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNA 930 940 950 960 970 980 480 490 500 510 520 530 pF1KE2 SATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGME 990 1000 1010 1020 1030 1040 540 550 560 570 580 590 pF1KE2 KYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMN 1050 1060 1070 1080 1090 1100 600 610 620 630 640 650 pF1KE2 AQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWK 1110 1120 1130 1140 1150 1160 660 670 680 690 700 710 pF1KE2 PQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRN 1170 1180 1190 1200 1210 1220 720 730 740 750 760 770 pF1KE2 RLSRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLSRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRG 1230 1240 1250 1260 1270 1280 780 790 800 810 820 830 pF1KE2 AANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESD 1290 1300 1310 1320 1330 1340 840 850 860 870 880 890 pF1KE2 LKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPV 1350 1360 1370 1380 1390 1400 900 910 920 930 940 950 pF1KE2 EMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLN 1410 1420 1430 1440 1450 1460 960 970 980 990 1000 1010 pF1KE2 VAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLM 1470 1480 1490 1500 1510 1520 1020 1030 1040 1050 1060 1070 pF1KE2 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ 1530 1540 1550 1560 1570 1580 1080 1090 1100 1110 1120 1130 pF1KE2 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC 1590 1600 1610 1620 1630 1640 1140 1150 1160 1170 1180 1190 pF1KE2 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAK 1650 1660 1670 1680 1690 1700 1200 1210 1220 1230 1240 1250 pF1KE2 HLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTE 1710 1720 1730 1740 1750 1760 1260 1270 1280 1290 1300 1310 pF1KE2 LKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDR 1770 1780 1790 1800 1810 1820 1320 1330 1340 1350 1360 1370 pF1KE2 RQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVR 1830 1840 1850 1860 1870 1880 1380 1390 1400 1410 1420 1430 pF1KE2 AAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMV 1890 1900 1910 1920 1930 1940 1440 1450 1460 1470 1480 1490 pF1KE2 VHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYL 1950 1960 1970 1980 1990 2000 1500 1510 1520 1530 1540 1550 pF1KE2 WHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDR 2010 2020 2030 2040 2050 2060 1560 1570 1580 1590 1600 1610 pF1KE2 KAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQP 2070 2080 2090 2100 2110 2120 1620 1630 1640 1650 1660 1670 pF1KE2 ALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSY 2130 2140 2150 2160 2170 2180 1680 1690 1700 1710 1720 1730 pF1KE2 LIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLA 2190 2200 2210 2220 2230 2240 1740 1750 1760 1770 1780 pF1KE2 RPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF :::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF 2250 2260 2270 2280 2290 >-- initn: 1828 init1: 1798 opt: 1802 Z-score: 1413.5 bits: 275.1 E(85289): 5.4e-72 Smith-Waterman score: 1802; 85.2% identity (91.6% similar) in 332 aa overlap (1-332:86-415) 10 20 30 pF1KE2 MKRKERIARRLEGIENDTQPILLQSCTGLV :::::::::::::::::::::::::::::: XP_016 RGIDAQLLVALPKVAELRQIFEPKKKEFLEMKRKERIARRLEGIENDTQPILLQSCTGLV 60 70 80 90 100 110 40 50 60 70 80 90 pF1KE2 THRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 THRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGS 120 130 140 150 160 170 100 110 120 130 140 150 pF1KE2 GTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRG 180 190 200 210 220 230 160 170 180 190 200 210 pF1KE2 GKSDKQEESSRDASSLYPGTETMGLRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKSDKQEESSRDASSLYPGTETMGLRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQE 240 250 260 270 280 290 220 230 240 250 260 270 pF1KE2 LSATRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSATRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLS 300 310 320 330 340 350 280 290 300 310 320 330 pF1KE2 PEARPRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE ::::: . .. .. . . : . .. .. . ... : . .: :. :.. : XP_016 PEARPSTGKPKHEWFLQKDSEGDTPSLINWPSRVKVREKLVKEESARNSPELASES--VT 360 370 380 390 400 410 340 350 360 370 380 390 pF1KE2 QRLRRLQDRSLTQPITTEEVVIAATLQASAHQKALAKDQTNEGKELAEQGEPDSSTLSLA :: XP_016 QRRHQPAPVHYVSFQSEHSAFDRVPSKAAGSTRQPIRGYVQPADTGHTAKLVTPETPENA 420 430 440 450 460 470 >>XP_011517932 (OMIM: 604126) PREDICTED: supervillin iso (2315 aa) initn: 11323 init1: 7012 opt: 7024 Z-score: 5494.9 bits: 1030.3 E(85289): 0 Smith-Waterman score: 9926; 95.3% identity (95.9% similar) in 1596 aa overlap (244-1788:722-2315) 220 230 240 250 260 270 pF1KE2 TRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSF-GDPQLSPE :.:.. : . .. . : : .: : : XP_011 ACRRPELKSRVERSAEGPGLPTGVERERGSRKPRRYFSPG--ESRKTSERFRTQPITSAE 700 710 720 730 740 280 290 300 310 320 330 pF1KE2 ARP--RCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE . ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKESDRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE 750 760 770 780 790 800 340 350 pF1KE2 QRLRRLQDRSLTQPITTEEVVIAAT--------------------------------LQA ::::::::::::::::::::::::: ::: XP_011 QRLRRLQDRSLTQPITTEEVVIAATEPIPASCSGGTHPVMARLPSPTVARSAVQPARLQA 810 820 830 840 850 860 360 370 380 390 400 410 pF1KE2 SAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQR 870 880 890 900 910 920 420 430 440 450 460 470 pF1KE2 RMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNA 930 940 950 960 970 980 480 490 500 510 520 530 pF1KE2 SATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGME 990 1000 1010 1020 1030 1040 540 550 560 570 580 590 pF1KE2 KYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMN 1050 1060 1070 1080 1090 1100 600 610 620 630 640 650 pF1KE2 AQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWK 1110 1120 1130 1140 1150 1160 660 670 680 690 700 710 pF1KE2 PQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRN 1170 1180 1190 1200 1210 1220 720 730 740 750 760 pF1KE2 RLSRRQEGGKAPASSLHTQEAGRSLIKK----------------RVTESRESQMTIEERK :::::::::::::::::::::::::::: :::::::::::::::: XP_011 RLSRRQEGGKAPASSLHTQEAGRSLIKKEEGGVADDSAISNLLWRVTESRESQMTIEERK 1230 1240 1250 1260 1270 1280 770 780 790 800 810 820 pF1KE2 QLITVREEAWKTRGRGAANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QLITVREEAWKTRGRGAANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSK 1290 1300 1310 1320 1330 1340 830 840 850 860 870 880 pF1KE2 PLEDIEARPDMQLESDLKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLEDIEARPDMQLESDLKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETF 1350 1360 1370 1380 1390 1400 890 900 910 920 930 940 pF1KE2 AKFYRSVDYNMPRSPVEMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AKFYRSVDYNMPRSPVEMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKML 1410 1420 1430 1440 1450 1460 950 960 970 980 990 1000 pF1KE2 AAREDLLQEYTEQRLNVAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAREDLLQEYTEQRLNVAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNL 1470 1480 1490 1500 1510 1520 1010 1020 1030 1040 1050 1060 pF1KE2 TEQNSNNSAVPYKRLMLLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TEQNSNNSAVPYKRLMLLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFA 1530 1540 1550 1560 1570 1580 1070 1080 1090 1100 1110 1120 pF1KE2 NVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGD 1590 1600 1610 1620 1630 1640 1130 1140 1150 1160 1170 1180 pF1KE2 PKEDELYEAAIIETNCIYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PKEDELYEAAIIETNCIYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHG 1650 1660 1670 1680 1690 1700 1190 1200 1210 1220 1230 1240 pF1KE2 KEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTE 1710 1720 1730 1740 1750 1760 1250 1260 1270 1280 1290 1300 pF1KE2 HNETILFKEKFLDWTELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HNETILFKEKFLDWTELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILD 1770 1780 1790 1800 1810 1820 1310 1320 1330 1340 1350 1360 pF1KE2 GVNVGRGYGLVEGHDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVNVGRGYGLVEGHDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFM 1830 1840 1850 1860 1870 1880 1370 1380 1390 1400 1410 1420 pF1KE2 VSTAVGSRQKGEHSVRAAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSTAVGSRQKGEHSVRAAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQ 1890 1900 1910 1920 1930 1940 1430 1440 1450 1460 1470 1480 pF1KE2 GKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRS 1950 1960 1970 1980 1990 2000 1490 1500 1510 1520 1530 1540 pF1KE2 RTSMVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RTSMVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDE 2010 2020 2030 2040 2050 2060 1550 1560 1570 1580 1590 1600 pF1KE2 GSEPLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSEPLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVV 2070 2080 2090 2100 2110 2120 1610 1620 1630 1640 1650 1660 pF1KE2 SSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVL 2130 2140 2150 2160 2170 2180 1670 1680 1690 1700 1710 1720 pF1KE2 QYCKGKNLKKPAPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QYCKGKNLKKPAPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDV 2190 2200 2210 2220 2230 2240 1730 1740 1750 1760 1770 1780 pF1KE2 LAKLCKTIYPLADLLARPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAKLCKTIYPLADLLARPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLK 2250 2260 2270 2280 2290 2300 pF1KE2 KAKGLF :::::: XP_011 KAKGLF 2310 >-- initn: 1828 init1: 1798 opt: 1802 Z-score: 1413.4 bits: 275.1 E(85289): 5.4e-72 Smith-Waterman score: 1802; 85.2% identity (91.6% similar) in 332 aa overlap (1-332:86-415) 10 20 30 pF1KE2 MKRKERIARRLEGIENDTQPILLQSCTGLV :::::::::::::::::::::::::::::: XP_011 RGIDAQLLVALPKVAELRQIFEPKKKEFLEMKRKERIARRLEGIENDTQPILLQSCTGLV 60 70 80 90 100 110 40 50 60 70 80 90 pF1KE2 THRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 THRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGS 120 130 140 150 160 170 100 110 120 130 140 150 pF1KE2 GTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRG 180 190 200 210 220 230 160 170 180 190 200 210 pF1KE2 GKSDKQEESSRDASSLYPGTETMGLRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GKSDKQEESSRDASSLYPGTETMGLRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQE 240 250 260 270 280 290 220 230 240 250 260 270 pF1KE2 LSATRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSATRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLS 300 310 320 330 340 350 280 290 300 310 320 330 pF1KE2 PEARPRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVE ::::: . .. .. . . : . .. .. . ... : . .: :. :.. : XP_011 PEARPSTGKPKHEWFLQKDSEGDTPSLINWPSRVKVREKLVKEESARNSPELASES--VT 360 370 380 390 400 410 340 350 360 370 380 390 pF1KE2 QRLRRLQDRSLTQPITTEEVVIAATLQASAHQKALAKDQTNEGKELAEQGEPDSSTLSLA :: XP_011 QRRHQPAPVHYVSFQSEHSAFDRVPSKAAGSTRQPIRGYVQPADTGHTAKLVTPETPENA 420 430 440 450 460 470 1788 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 20:57:55 2016 done: Mon Nov 7 20:57:57 2016 Total Scan time: 12.940 Total Display time: 1.220 Function used was FASTA [36.3.4 Apr, 2011]