Result of FASTA (omim) for pF1KE2391
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE2391, 517 aa
  1>>>pF1KE2391 517 - 517 aa - 517 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 4.8820+/-0.000307; mu= 21.0582+/- 0.019
 mean_var=62.9781+/-12.471, 0's: 0 Z-trim(116.3): 168  B-trim: 15 in 1/52
 Lambda= 0.161614
 statistics sampled from 27145 (27315) to 27145 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.677), E-opt: 0.2 (0.32), width:  16
 Scan time: 10.130

The best scores are:                                      opt bits E(85289)
NP_000742 (OMIM: 100720,253290,616321,616322,61632 ( 517) 3452 813.3       0
NP_001243586 (OMIM: 100720,253290,616321,616322,61 ( 502) 2953 697.0 3.4e-200
NP_001298125 (OMIM: 100720,253290,616321,616322,61 ( 416) 2670 631.0 2.1e-180
XP_011508826 (OMIM: 100720,253290,616321,616322,61 ( 390) 2053 487.1 4.1e-137
NP_001298124 (OMIM: 100720,253290,616321,616322,61 ( 323) 1593 379.8 6.8e-105
NP_005190 (OMIM: 100730,253290,265000) acetylcholi ( 517) 1547 369.2 1.7e-101
NP_000071 (OMIM: 100725,605809,608931,616324) acet ( 493) 1308 313.4 9.6e-85
XP_016879604 (OMIM: 100725,605809,608931,616324) P ( 481) 1296 310.6 6.5e-84
NP_000738 (OMIM: 100710,616313,616314) acetylcholi ( 501) 1268 304.1 6.2e-82
XP_016855669 (OMIM: 118507,605375) PREDICTED: neur ( 332)  726 177.6   5e-44
XP_011519493 (OMIM: 118509) PREDICTED: neuronal ac ( 424)  713 174.7 4.9e-43
XP_011519492 (OMIM: 118509) PREDICTED: neuronal ac ( 424)  713 174.7 4.9e-43
XP_016877374 (OMIM: 118509) PREDICTED: neuronal ac ( 468)  713 174.7 5.3e-43
XP_016877375 (OMIM: 118509) PREDICTED: neuronal ac ( 468)  713 174.7 5.3e-43
XP_011519494 (OMIM: 118509) PREDICTED: neuronal ac ( 316)  699 171.3 3.8e-42
NP_001186208 (OMIM: 606888) neuronal acetylcholine ( 479)  670 164.7 5.7e-40
NP_004189 (OMIM: 606888) neuronal acetylcholine re ( 494)  670 164.7 5.8e-40
NP_000739 (OMIM: 118507,605375) neuronal acetylcho ( 502)  623 153.7 1.2e-36
XP_006716345 (OMIM: 118502,610353) PREDICTED: neur ( 529)  619 152.8 2.3e-36
XP_011542690 (OMIM: 118502,610353) PREDICTED: neur ( 529)  619 152.8 2.3e-36
NP_000733 (OMIM: 118502,610353) neuronal acetylcho ( 529)  619 152.8 2.3e-36
XP_016877378 (OMIM: 118509) PREDICTED: neuronal ac ( 449)  564 139.9 1.5e-32
XP_016877377 (OMIM: 118509) PREDICTED: neuronal ac ( 462)  564 139.9 1.5e-32
XP_016877376 (OMIM: 118509) PREDICTED: neuronal ac ( 463)  564 140.0 1.5e-32
NP_000741 (OMIM: 118509) neuronal acetylcholine re ( 498)  564 140.0 1.6e-32
XP_006720445 (OMIM: 118503,612052) PREDICTED: neur ( 438)  562 139.5   2e-32
NP_001160166 (OMIM: 118503,612052) neuronal acetyl ( 489)  562 139.5 2.2e-32
NP_000734 (OMIM: 118503,612052) neuronal acetylcho ( 505)  562 139.5 2.2e-32
XP_011519488 (OMIM: 118509) PREDICTED: neuronal ac ( 495)  549 136.5 1.8e-31
XP_011519489 (OMIM: 118509) PREDICTED: neuronal ac ( 495)  549 136.5 1.8e-31
NP_000740 (OMIM: 118508) neuronal acetylcholine re ( 458)  546 135.7 2.8e-31
NP_000070 (OMIM: 100690,253290,601462,608930) acet ( 457)  534 133.0 1.9e-30
XP_016858746 (OMIM: 100690,253290,601462,608930) P ( 464)  534 133.0 1.9e-30
NP_001034612 (OMIM: 100690,253290,601462,608930) a ( 482)  534 133.0   2e-30
XP_016858745 (OMIM: 100690,253290,601462,608930) P ( 489)  534 133.0   2e-30
XP_016883114 (OMIM: 118504,188890,600513) PREDICTE ( 451)  530 132.0 3.6e-30
NP_001243502 (OMIM: 118504,188890,600513) neuronal ( 451)  530 132.0 3.6e-30
XP_016883113 (OMIM: 118504,188890,600513) PREDICTE ( 546)  530 132.1 4.2e-30
XP_011526826 (OMIM: 118504,188890,600513) PREDICTE ( 556)  530 132.1 4.3e-30
NP_000735 (OMIM: 118504,188890,600513) neuronal ac ( 627)  530 132.1 4.7e-30
XP_005254199 (OMIM: 118505,612052) PREDICTED: neur ( 243)  522 130.0 8.1e-30
XP_016877370 (OMIM: 118505,612052) PREDICTED: neur ( 245)  522 130.0 8.1e-30
XP_016868492 (OMIM: 118502,610353) PREDICTED: neur ( 370)  524 130.6 8.2e-30
XP_005273454 (OMIM: 118502,610353) PREDICTED: neur ( 370)  524 130.6 8.2e-30
NP_001269384 (OMIM: 118502,610353) neuronal acetyl ( 514)  524 130.7 1.1e-29
XP_016868493 (OMIM: 118502,610353) PREDICTED: neur ( 331)  520 129.6 1.4e-29
XP_011542691 (OMIM: 118502,610353) PREDICTED: neur ( 331)  520 129.6 1.4e-29
XP_011542692 (OMIM: 118508) PREDICTED: neuronal ac ( 329)  469 117.7 5.4e-26
XP_011519480 (OMIM: 118511,612001) PREDICTED: neur ( 380)  459 115.4   3e-25
NP_000737 (OMIM: 118511,612001) neuronal acetylcho ( 502)  459 115.5 3.8e-25


>>NP_000742 (OMIM: 100720,253290,616321,616322,616323) a  (517 aa)
 initn: 3452 init1: 3452 opt: 3452  Z-score: 4343.8  bits: 813.3 E(85289):    0
Smith-Waterman score: 3452; 100.0% identity (100.0% similar) in 517 aa overlap (1-517:1-517)

               10        20        30        40        50        60
pF1KE2 MEGPVLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MEGPVLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 SNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNND
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNND
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 GSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEIT
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 LSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE2 IIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLP
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE2 ATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLH
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE2 MSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRP
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE2 PASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPV
              430       440       450       460       470       480

              490       500       510       
pF1KE2 MVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
       :::::::::::::::::::::::::::::::::::::
NP_000 MVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
              490       500       510       

>>NP_001243586 (OMIM: 100720,253290,616321,616322,616323  (502 aa)
 initn: 2945 init1: 2945 opt: 2953  Z-score: 3715.2  bits: 697.0 E(85289): 3.4e-200
Smith-Waterman score: 3315; 97.1% identity (97.1% similar) in 517 aa overlap (1-517:1-502)

               10        20        30        40        50        60
pF1KE2 MEGPVLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEGPVLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 SNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNND
       ::::::               :::::::::::::::::::::::::::::::::::::::
NP_001 SNLISL---------------GWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNND
                              70        80        90       100     

              130       140       150       160       170       180
pF1KE2 GSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEIT
         110       120       130       140       150       160     

              190       200       210       220       230       240
pF1KE2 LSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYL
         170       180       190       200       210       220     

              250       260       270       280       290       300
pF1KE2 IIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLP
         230       240       250       260       270       280     

              310       320       330       340       350       360
pF1KE2 ATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLH
         290       300       310       320       330       340     

              370       380       390       400       410       420
pF1KE2 MSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRP
         350       360       370       380       390       400     

              430       440       450       460       470       480
pF1KE2 PASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPV
         410       420       430       440       450       460     

              490       500       510       
pF1KE2 MVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
       :::::::::::::::::::::::::::::::::::::
NP_001 MVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
         470       480       490       500  

>>NP_001298125 (OMIM: 100720,253290,616321,616322,616323  (416 aa)
 initn: 2670 init1: 2670 opt: 2670  Z-score: 3359.7  bits: 631.0 E(85289): 2.1e-180
Smith-Waterman score: 2670; 100.0% identity (100.0% similar) in 399 aa overlap (119-517:18-416)

       90       100       110       120       130       140        
pF1KE2 KWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPPAIFR
                                     ::::::::::::::::::::::::::::::
NP_001              MLKNLETSVSCASPRTCNDGSFQISYSCNVLVYHYGFVYWLPPAIFR
                            10        20        30        40       

      150       160       170       180       190       200        
pF1KE2 SSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTEN
        50        60        70        80        90       100       

      210       220       230       240       250       260        
pF1KE2 GEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVF
       110       120       130       140       150       160       

      270       280       290       300       310       320        
pF1KE2 YLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICV
       170       180       190       200       210       220       

      330       340       350       360       370       380        
pF1KE2 IVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVRRSSSLGYISKAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVRRSSSLGYISKAE
       230       240       250       260       270       280       

      390       400       410       420       430       440        
pF1KE2 EYFLLKSRSDLMFEKQSERHGLARRLTTARRPPASSEQAQQELFNELKPAVDGANFIVNH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYFLLKSRSDLMFEKQSERHGLARRLTTARRPPASSEQAQQELFNELKPAVDGANFIVNH
       290       300       310       320       330       340       

      450       460       470       480       490       500        
pF1KE2 MRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPYS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPYS
       350       360       370       380       390       400       

      510       
pF1KE2 YNVQDKRFI
       :::::::::
NP_001 YNVQDKRFI
       410      

>>XP_011508826 (OMIM: 100720,253290,616321,616322,616323  (390 aa)
 initn: 2053 init1: 2053 opt: 2053  Z-score: 2582.6  bits: 487.1 E(85289): 4.1e-137
Smith-Waterman score: 2053; 99.7% identity (100.0% similar) in 312 aa overlap (206-517:79-390)

         180       190       200       210       220       230     
pF1KE2 AKEITLSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQD
                                     .:::::::::::::::::::::::::::::
XP_011 CTGCHLPSSAPPAPSLSPISPSTGRTAPSSSENGEWEIVHRPARVNVDPRAPLDSPSRQD
       50        60        70        80        90       100        

         240       250       260       270       280       290     
pF1KE2 ITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLI
      110       120       130       140       150       160        

         300       310       320       330       340       350     
pF1KE2 SKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETL
      170       180       190       200       210       220        

         360       370       380       390       400       410     
pF1KE2 PELLHMSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PELLHMSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLT
      230       240       250       260       270       280        

         420       430       440       450       460       470     
pF1KE2 TARRPPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TARRPPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLF
      290       300       310       320       330       340        

         480       490       500       510       
pF1KE2 VVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
       ::::::::::::::::::::::::::::::::::::::::::
XP_011 VVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
      350       360       370       380       390

>>NP_001298124 (OMIM: 100720,253290,616321,616322,616323  (323 aa)
 initn: 1590 init1: 1590 opt: 1593  Z-score: 2004.1  bits: 379.8 E(85289): 6.8e-105
Smith-Waterman score: 1593; 98.8% identity (99.6% similar) in 248 aa overlap (271-517:76-323)

              250       260       270        280       290         
pF1KE2 IIRRKPLFYIINILVPCVLISFMVNLVFYLPADSG-EKTSVAISVLLAQSVFLLLISKRL
                                     :..:: ::::::::::::::::::::::::
NP_001 TASCTGCHLPSSAPPAPSLSPISPSTGRTAPSSSGGEKTSVAISVLLAQSVFLLLISKRL
          50        60        70        80        90       100     

     300       310       320       330       340       350         
pF1KE2 PATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELL
         110       120       130       140       150       160     

     360       370       380       390       400       410         
pF1KE2 HMSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HMSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARR
         170       180       190       200       210       220     

     420       430       440       450       460       470         
pF1KE2 PPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTP
         230       240       250       260       270       280     

     480       490       500       510       
pF1KE2 VMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
       ::::::::::::::::::::::::::::::::::::::
NP_001 VMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
         290       300       310       320   

>>NP_005190 (OMIM: 100730,253290,265000) acetylcholine r  (517 aa)
 initn: 1119 init1: 617 opt: 1547  Z-score: 1943.3  bits: 369.2 E(85289): 1.7e-101
Smith-Waterman score: 1547; 48.2% identity (74.9% similar) in 521 aa overlap (2-509:5-512)

                  10         20        30        40        50      
pF1KE2    MEGPVLTLGLLAALAVC-GSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVAL
           .::.:   ::  :::: :. : :.::::.  :.:  .:. .:::. .  . :.:.:
NP_005 MHGGQGPLL---LLLLLAVCLGAQGRNQEERLLADLMQ--NYDPNLRPAERDSDVVNVSL
                  10        20        30          40        50     

         60        70        80        90       100       110      
pF1KE2 ALTLSNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLE
        :::.:::::.: ::.::::::::  : : ::.:. ... .. :::.:  ::: :.::::
NP_005 KLTLTNLISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLE
          60        70        80        90       100       110     

        120       130       140       150       160       170      
pF1KE2 NNNDGSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTA
       :: :: :...  :::::   : .::::::::::.: ::::::::::::::: :.:  :..
NP_005 NNVDGVFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYST
         120       130       140       150       160       170     

        180       190       200       210       220       230      
pF1KE2 KEITLSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDI
       .:: :.:.:.  ...:  .:::.::::.::::::: : ::::.. .:: :: .  ..: .
NP_005 NEIDLQLSQE--DGQT--IEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKV
         180           190       200       210       220       230 

        240       250       260       270        280       290     
pF1KE2 TFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSG-EKTSVAISVLLAQSVFLLLI
       .:::.:.::::::.:::..:::::: .. :. .::: .: .: .:::.:::::.:::.:.
NP_005 VFYLLIQRKPLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLV
             240       250       260       270       280       290 

         300       310       320       330       340       350     
pF1KE2 SKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETL
       .:..: ::.:.:::.:.: : .:.. ..::  :.:::. .:.: :: ...::.:.::. :
NP_005 AKKVPETSQAVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLL
             300       310       320       330       340       350 

         360        370        380        390       400       410  
pF1KE2 PELLHMS-RPAEDGPSPGALVR-RSSSLGY-ISKAEEYFLLKSRSDLMFEKQSERHGL-A
       :.::.:  ::   .    .  : ...: :. :. .::  :   ::.:.:. : .:.:: :
NP_005 PQLLRMHVRPLAPAAVQDTQSRLQNGSSGWSITTGEEVALCLPRSELLFQ-QWQRQGLVA
             360       370       380       390       400        410

             420       430              440       450       460    
pF1KE2 RRLTTARRPPASSEQAQQELFNELK---PA----VDGANFIVNHMRDQNNYNEEKDSWNR
         :   .. :   : . ... . ::   ::    :.. :.:.   ..:..... .. :  
NP_005 AALEKLEKGP---ELGLSQFCGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFL
              420          430       440       450       460       

          470       480       490       500       510       
pF1KE2 VARTVDRLCLFVVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
       :.:..::.:....  ... ::: :::.. ::. :  ::::::  :        
NP_005 VGRVLDRVCFLAMLSLFICGTAGIFLMAHYNRVPALPFPGDPRPYLPSPD   
       470       480       490       500       510          

>>NP_000071 (OMIM: 100725,605809,608931,616324) acetylch  (493 aa)
 initn: 1424 init1: 582 opt: 1308  Z-score: 1642.4  bits: 313.4 E(85289): 9.6e-85
Smith-Waterman score: 1432; 46.1% identity (73.8% similar) in 497 aa overlap (8-502:6-487)

               10         20        30        40        50         
pF1KE2 MEGPVLTLGLLAALAVCG-SWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALT
              ::.:  :.. : . : ::: :: .:::..  :.   ::: . :..: ..: .:
NP_000   MARAPLGVLLLLGLLGRGVGKNEELRLYHHLFNN--YDPGSRPVREPEDTVTISLKVT
                 10        20        30          40        50      

      60        70        80        90       100       110         
pF1KE2 LSNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNN
       :.:::::.: ::::::.:::   : : ::... ..::.: .::.: ..::::::::::: 
NP_000 LTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNI
         60        70        80        90       100       110      

     120       130       140       150       160       170         
pF1KE2 DGSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEI
       ::.: ..:. :::::. : : ::::::.:: : . ::::::::::::: : :  :.:.:.
NP_000 DGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEV
        120       130       140       150       160       170      

     180       190       200       210       220       230         
pF1KE2 TLSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFY
        ...  : ....:  .. : :: :..:::::: :   :. .     .  :.:.. :. . 
NP_000 EFTFAVD-NDGKT--INKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYS
        180          190       200       210       220       230   

     240       250       260       270        280       290        
pF1KE2 LIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSG-EKTSVAISVLLAQSVFLLLISKR
       ::::::::::.:::.::::::: .: :...:::..: .: .:.:.:::::.:::.::...
NP_000 LIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQK
           240       250       260       270       280       290   

      300       310       320       330       340       350        
pF1KE2 LPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPEL
       .: ::...::.:.::.: ::..:..:. ::::::.  :::.::..:  .....:: ::.:
NP_000 IPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRL
           300       310       320       330       340       350   

      360       370       380       390       400       410        
pF1KE2 LHMSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTAR
       :  : :  ..:  ..  ::.::.: . .::: .: : ::.:.:: : .:.:         
NP_000 LG-SPPPPEAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWT------
            360       370       380       390       400            

      420       430       440       450       460       470        
pF1KE2 RPPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVT
          :.  :.      :..  ::..::...  :::.  .:: ..: :.. ..: .:.... 
NP_000 ---AAFCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAAL
           410       420       430       440       450       460   

      480       490       500       510       
pF1KE2 PVMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
        .. ::.. ::: . .:. :  :.               
NP_000 VLFSVGSSLIFLGAYFNRVPDLPYAPCIQP         
           470       480       490            

>>XP_016879604 (OMIM: 100725,605809,608931,616324) PREDI  (481 aa)
 initn: 1424 init1: 582 opt: 1296  Z-score: 1627.4  bits: 310.6 E(85289): 6.5e-84
Smith-Waterman score: 1420; 46.4% identity (74.1% similar) in 483 aa overlap (21-502:8-475)

               10        20        30        40        50        60
pF1KE2 MEGPVLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTL
                           : ::: :: .:::..  :.   ::: . :..: ..: .::
XP_016              MQRGRGVGKNEELRLYHHLFNN--YDPGSRPVREPEDTVTISLKVTL
                            10        20          30        40     

               70        80        90       100       110       120
pF1KE2 SNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNND
       .:::::.: ::::::.:::   : : ::... ..::.: .::.: ..::::::::::: :
XP_016 TNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNID
          50        60        70        80        90       100     

              130       140       150       160       170       180
pF1KE2 GSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEIT
       :.: ..:. :::::. : : ::::::.:: : . ::::::::::::: : :  :.:.:. 
XP_016 GQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVE
         110       120       130       140       150       160     

              190       200       210       220       230       240
pF1KE2 LSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYL
       ...  : ....:  .. : :: :..:::::: :   :. .     .  :.:.. :. . :
XP_016 FTFAVD-NDGKT--INKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSL
         170          180       190       200       210       220  

              250       260       270        280       290         
pF1KE2 IIRRKPLFYIINILVPCVLISFMVNLVFYLPADSG-EKTSVAISVLLAQSVFLLLISKRL
       :::::::::.:::.::::::: .: :...:::..: .: .:.:.:::::.:::.::....
XP_016 IIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKI
            230       240       250       260       270       280  

     300       310       320       330       340       350         
pF1KE2 PATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELL
       : ::...::.:.::.: ::..:..:. ::::::.  :::.::..:  .....:: ::.::
XP_016 PETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLL
            290       300       310       320       330       340  

     360       370       380       390       400       410         
pF1KE2 HMSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARR
         : :  ..:  ..  ::.::.: . .::: .: : ::.:.:: : .:.:          
XP_016 G-SPPPPEAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWT-------
             350       360       370       380       390           

     420       430       440       450       460       470         
pF1KE2 PPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTP
         :.  :.      :..  ::..::...  :::.  .:: ..: :.. ..: .:....  
XP_016 --AAFCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALV
            400       410       420       430       440       450  

     480       490       500       510       
pF1KE2 VMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
       .. ::.. ::: . .:. :  :.               
XP_016 LFSVGSSLIFLGAYFNRVPDLPYAPCIQP         
            460       470       480          

>>NP_000738 (OMIM: 100710,616313,616314) acetylcholine r  (501 aa)
 initn: 1214 init1: 491 opt: 1268  Z-score: 1591.9  bits: 304.1 E(85289): 6.2e-82
Smith-Waterman score: 1268; 40.4% identity (70.0% similar) in 507 aa overlap (5-503:7-501)

                 10        20        30        40        50        
pF1KE2   MEGPVLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALAL
             .. :: :.:  . :  : . : :: ..::  .::.. .::. .  . : :...:
NP_000 MTPGALLMLLGALGAPLAPGVRGSEAEGRLREKLF--SGYDSSVRPAREVGDRVRVSVGL
               10        20        30          40        50        

       60        70        80        90       100       110        
pF1KE2 TLSNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENN
        :..::::.: .: ..:.:...  ::: ::.:.  :  .:. ::.  . ::::..:: ::
NP_000 ILAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNN
       60        70        80        90       100       110        

      120       130       140       150       160       170        
pF1KE2 NDGSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKE
       :::.:... . .:.:   : : : ::.:.:::: :.:::::::::::.. ::: .: ..:
NP_000 NDGNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSE
      120       130       140       150       160       170        

      180         190       200        210       220       230     
pF1KE2 ITLS--LKQDAKENRTYPVEWIIIDPEG-FTENGEWEIVHRPARVNVDPRAPLDS--PSR
       ..:.  :  :.. ..   ..      :: : :::.:::.:.:.:.   :  :  .   .:
NP_000 VSLQTGLGPDGQGHQEIHIH------EGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQR
      180       190             200       210       220       230  

           240       250       260       270       280       290   
pF1KE2 QDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLL
       :.. ::::::::::::..:...::.::.... .::::: :.::: ...: .::. .::::
NP_000 QEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLL
            240       250       260       270       280       290  

           300       310       320       330       340       350   
pF1KE2 LISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLE
       :.. ..: ::...:.: :.:.: :::::. :.. :.:::.: :.: :: .   :...:..
NP_000 LLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIH
            300       310       320       330       340       350  

           360          370       380       390       400       410
pF1KE2 TLPELLHMSRPAEDG---PSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGL
        ::  :...::  .    : :      : . :.   ..:::. :  ::..: : . :   
NP_000 KLPLYLRLKRPKPERDLMPEPPHC--SSPGSGWGRGTDEYFIRKPPSDFLFPKPN-RFQP
            360       370         380       390       400          

              420       430       440       450       460       470
pF1KE2 ARRLTTARRPPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVD
              ::   . ..:   :. ::. .:.. ..:. ....:....  :..:. :: .::
NP_000 ELSAPDLRRFIDGPNRAVA-LLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVD
     410       420        430       440       450       460        

              480       490       500       510       
pF1KE2 RLCLFVVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
       :: :..      :::  :::...:. :::.:::              
NP_000 RLFLWTFIIFTSVGTLVIFLDATYHLPPPDPFP              
      470       480       490       500               

>>XP_016855669 (OMIM: 118507,605375) PREDICTED: neuronal  (332 aa)
 initn: 776 init1: 527 opt: 726  Z-score: 911.5  bits: 177.6 E(85289): 5e-44
Smith-Waterman score: 739; 39.9% identity (63.6% similar) in 338 aa overlap (167-502:1-321)

        140       150       160       170       180       190      
pF1KE2 GFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVE
                                     .:: :  :   :: : ::..          
XP_016                               MKFRSWTYDRTEIDLVLKSE----------
                                             10        20          

        200       210       220       230       240       250      
pF1KE2 WIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVP
         . . . :: .:::.::  :.: : .:    :. .  :::. .::::::::: ::...:
XP_016 --VASLDDFTPSGEWDIVALPGRRNENP----DDSTYVDITYDFIIRRKPLFYTINLIIP
                 30        40            50        60        70    

        260       270       280       290       300       310      
pF1KE2 CVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFG
       ::::. .. ::::::.: ::: .. :::::: .:::::::: .: ::. .::.::.:.: 
XP_016 CVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFT
           80        90       100       110       120       130    

        320       330       340       350       360       370      
pF1KE2 MVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVR
       :::::. .:  : :::.: :.:.::...  :: .::: :: :: :..: .        .:
XP_016 MVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLR
          140       150       160       170       180       190    

        380       390         400       410       420       430    
pF1KE2 RSSSLGYISKAEEYFLLKSRSD--LMFEKQSERHGLARRLTTARRPPASSEQAQQELFNE
       : .     . :  .:     .:    : ...  .:::  . .   : :.  .. .     
XP_016 RRQREREGAGAL-FFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPCGCG
          200        210       220       230       240       250   

          440       450       460       470       480       490    
pF1KE2 LKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIFLQGVY
       :. ::::. ::..:::.... .  ...:. :: ..::: :.. . : : ::  .::: ..
XP_016 LREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLF
           260       270       280       290       300       310   

          500       510       
pF1KE2 NQPPPQPFPGDPYSYNVQDKRFI
       ..     :               
XP_016 QNYTTTTFLHSDHSAPSSK    
           320       330      




517 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sun Nov  6 09:29:37 2016 done: Sun Nov  6 09:29:39 2016
 Total Scan time: 10.130 Total Display time:  0.090

Function used was FASTA [36.3.4 Apr, 2011]
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