Result of FASTA (omim) for pF1KE2408
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE2408, 2168 aa
  1>>>pF1KE2408 2168 - 2168 aa - 2168 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 14.7365+/-0.000569; mu= -19.8859+/- 0.036
 mean_var=580.3311+/-118.454, 0's: 0 Z-trim(121.2): 118  B-trim: 0 in 0/52
 Lambda= 0.053240
 statistics sampled from 37229 (37357) to 37229 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.721), E-opt: 0.2 (0.438), width:  16
 Scan time: 24.630

The best scores are:                                      opt bits E(85289)
NP_038478 (OMIM: 605683) bromodomain adjacent to z (2168) 14213 1108.7       0
XP_011509341 (OMIM: 605683) PREDICTED: bromodomain (2231) 12317 963.1       0
NP_001276904 (OMIM: 605683) bromodomain adjacent t (2132) 8992 707.7 3.7e-202
XP_011509344 (OMIM: 605683) PREDICTED: bromodomain (2207) 8229 649.1 1.6e-184
XP_011509353 (OMIM: 605683) PREDICTED: bromodomain (2141) 7994 631.0 4.4e-179
NP_001316787 (OMIM: 605683) bromodomain adjacent t (2143) 7986 630.4 6.7e-179
XP_011509345 (OMIM: 605683) PREDICTED: bromodomain (2197) 7096 562.1 2.6e-158
XP_016859412 (OMIM: 605683) PREDICTED: bromodomain (2212) 6655 528.2 4.1e-148
XP_011509340 (OMIM: 605683) PREDICTED: bromodomain (2240) 6655 528.2 4.1e-148
XP_011509356 (OMIM: 605683) PREDICTED: bromodomain (1976) 6629 526.2 1.5e-147
XP_011509355 (OMIM: 605683) PREDICTED: bromodomain (2036) 6629 526.2 1.5e-147
XP_005246546 (OMIM: 605683) PREDICTED: bromodomain (2242) 6629 526.2 1.6e-147
XP_016859407 (OMIM: 605683) PREDICTED: bromodomain (2242) 6629 526.2 1.6e-147
XP_016859409 (OMIM: 605683) PREDICTED: bromodomain (2242) 6629 526.2 1.6e-147
XP_016859408 (OMIM: 605683) PREDICTED: bromodomain (2242) 6629 526.2 1.6e-147
XP_006712524 (OMIM: 605683) PREDICTED: bromodomain (2242) 6629 526.2 1.6e-147
XP_005246545 (OMIM: 605683) PREDICTED: bromodomain (2242) 6629 526.2 1.6e-147
NP_001316786 (OMIM: 605683) bromodomain adjacent t (2149) 6350 504.8 4.5e-141
XP_016859415 (OMIM: 605683) PREDICTED: bromodomain (2175) 6350 504.8 4.5e-141
XP_005246549 (OMIM: 605683) PREDICTED: bromodomain (2240) 6343 504.2 6.7e-141
XP_016859411 (OMIM: 605683) PREDICTED: bromodomain (2240) 6343 504.2 6.7e-141
XP_016859410 (OMIM: 605683) PREDICTED: bromodomain (2240) 6343 504.2 6.7e-141
XP_011509347 (OMIM: 605683) PREDICTED: bromodomain (2177) 6325 502.8 1.7e-140
XP_011509350 (OMIM: 605683) PREDICTED: bromodomain (2179) 6325 502.8 1.7e-140
XP_011509349 (OMIM: 605683) PREDICTED: bromodomain (2179) 6325 502.8 1.7e-140
XP_016859413 (OMIM: 605683) PREDICTED: bromodomain (2206) 6154 489.7 1.6e-136
XP_016859414 (OMIM: 605683) PREDICTED: bromodomain (2208) 6148 489.2 2.2e-136
XP_016859421 (OMIM: 605683) PREDICTED: bromodomain (2113) 6090 484.8 4.6e-135
XP_011509346 (OMIM: 605683) PREDICTED: bromodomain (2178) 6090 484.8 4.7e-135
XP_011509358 (OMIM: 605683) PREDICTED: bromodomain (1426) 5998 477.6 4.5e-133
XP_016859424 (OMIM: 605683) PREDICTED: bromodomain (2047) 5998 477.7  6e-133
XP_016859423 (OMIM: 605683) PREDICTED: bromodomain (2079) 5998 477.7  6e-133
XP_016859422 (OMIM: 605683) PREDICTED: bromodomain (2081) 5998 477.7  6e-133
XP_011509354 (OMIM: 605683) PREDICTED: bromodomain (2110) 5998 477.7 6.1e-133
XP_011509352 (OMIM: 605683) PREDICTED: bromodomain (2142) 5998 477.7 6.2e-133
XP_016859417 (OMIM: 605683) PREDICTED: bromodomain (2144) 5998 477.7 6.2e-133
XP_016859425 (OMIM: 605683) PREDICTED: bromodomain (2015) 5965 475.2 3.4e-132
XP_016859420 (OMIM: 605683) PREDICTED: bromodomain (2140) 5965 475.2 3.6e-132
XP_016859419 (OMIM: 605683) PREDICTED: bromodomain (2142) 5965 475.2 3.6e-132
XP_016859426 (OMIM: 605683) PREDICTED: bromodomain (1317) 5934 472.6 1.3e-131
XP_011536111 (OMIM: 605682) PREDICTED: bromodomain (1362)  904 86.3 2.6e-15
XP_016874231 (OMIM: 605682) PREDICTED: bromodomain (1873)  904 86.4 3.4e-15
XP_011536101 (OMIM: 605682) PREDICTED: bromodomain (1882)  904 86.4 3.4e-15
NP_001287834 (OMIM: 605682) bromodomain adjacent t (1903)  904 86.4 3.4e-15
XP_011536100 (OMIM: 605682) PREDICTED: bromodomain (1904)  904 86.4 3.4e-15
NP_038477 (OMIM: 605682) bromodomain adjacent to z (1905)  904 86.4 3.4e-15
XP_016874230 (OMIM: 605682) PREDICTED: bromodomain (1910)  904 86.4 3.4e-15
XP_011536108 (OMIM: 605682) PREDICTED: bromodomain (1910)  904 86.4 3.4e-15
XP_011536105 (OMIM: 605682) PREDICTED: bromodomain (1910)  904 86.4 3.4e-15
XP_016874229 (OMIM: 605682) PREDICTED: bromodomain (1910)  904 86.4 3.4e-15


>>NP_038478 (OMIM: 605683) bromodomain adjacent to zinc   (2168 aa)
 initn: 14213 init1: 14213 opt: 14213  Z-score: 5917.6  bits: 1108.7 E(85289):    0
Smith-Waterman score: 14213; 100.0% identity (100.0% similar) in 2168 aa overlap (1-2168:1-2168)

               10        20        30        40        50        60
pF1KE2 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE2 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE2 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE2 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE2 SSLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
       : ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 SLLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE2 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE2 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE2 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE2 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE2 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE2 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE2 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE2 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KE2 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQERERRRQHMMLMKAMEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQERERRRQHMMLMKAMEA
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KE2 RKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQKPLPELPRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 RKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQKPLPELPRI
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KE2 PGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDSMGEVQDLLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 PGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDSMGEVQDLLV
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KE2 RLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQTELTESLKTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 RLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQTELTESLKTK
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KE2 AFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGKLRKLRIIHA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 AFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGKLRKLRIIHA
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KE2 KKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQGDEDDEDEED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 KKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQGDEDDEDEED
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KE2 KEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHSLRSVMFGQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 KEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHSLRSVMFGQD
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KE2 RYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNCSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 RYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNCSN
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KE2 TDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNAGANGCTLSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 TDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNAGANGCTLSY
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KE2 QNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 QNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWF
             1510      1520      1530      1540      1550      1560

             1570      1580      1590      1600      1610      1620
pF1KE2 SLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 SLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPL
             1570      1580      1590      1600      1610      1620

             1630      1640      1650      1660      1670      1680
pF1KE2 QVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTSNVASSKSES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 QVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTSNVASSKSES
             1630      1640      1650      1660      1670      1680

             1690      1700      1710      1720      1730      1740
pF1KE2 PVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 PVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIR
             1690      1700      1710      1720      1730      1740

             1750      1760      1770      1780      1790      1800
pF1KE2 EKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 EKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVL
             1750      1760      1770      1780      1790      1800

             1810      1820      1830      1840      1850      1860
pF1KE2 QQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEFTGEDESSAH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 QQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEFTGEDESSAH
             1810      1820      1830      1840      1850      1860

             1870      1880      1890      1900      1910      1920
pF1KE2 ALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSAAQVALCIQQLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 ALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSAAQVALCIQQLQ
             1870      1880      1890      1900      1910      1920

             1930      1940      1950      1960      1970      1980
pF1KE2 KSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 KSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIA
             1930      1940      1950      1960      1970      1980

             1990      2000      2010      2020      2030      2040
pF1KE2 KASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 KASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEE
             1990      2000      2010      2020      2030      2040

             2050      2060      2070      2080      2090      2100
pF1KE2 NTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 NTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKV
             2050      2060      2070      2080      2090      2100

             2110      2120      2130      2140      2150      2160
pF1KE2 IKKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 IKKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKK
             2110      2120      2130      2140      2150      2160

               
pF1KE2 WTDTFKVS
       ::::::::
NP_038 WTDTFKVS
               

>>XP_011509341 (OMIM: 605683) PREDICTED: bromodomain adj  (2231 aa)
 initn: 14189 init1: 12317 opt: 12317  Z-score: 5130.4  bits: 963.1 E(85289):    0
Smith-Waterman score: 14117; 98.4% identity (98.4% similar) in 2200 aa overlap (1-2165:1-2200)

               10        20        30        40        50        60
pF1KE2 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE2 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE2 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE2 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE2 SSLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
       : ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE2 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE2 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE2 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE2 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE2 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE2 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE2 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE2 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KE2 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQERERRRQHMMLMKAMEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQERERRRQHMMLMKAMEA
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KE2 RKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQKPLPELPRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQKPLPELPRI
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KE2 PGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDSMGEVQDLLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDSMGEVQDLLV
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KE2 RLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQTELTESLKTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQTELTESLKTK
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KE2 AFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGKLRKLRIIHA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGKLRKLRIIHA
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KE2 KKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQGDEDDEDEED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQGDEDDEDEED
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KE2 KEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHSLRSVMFGQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHSLRSVMFGQD
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KE2 RYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNCSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNCSN
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KE2 TDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNAGANGCTLSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNAGANGCTLSY
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KE2 QNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWF
             1510      1520      1530      1540      1550      1560

             1570      1580      1590      1600      1610      1620
pF1KE2 SLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPL
             1570      1580      1590      1600      1610      1620

             1630      1640      1650      1660      1670      1680
pF1KE2 QVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTSNVASSKSES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTSNVASSKSES
             1630      1640      1650      1660      1670      1680

             1690      1700      1710      1720      1730      1740
pF1KE2 PVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIR
             1690      1700      1710      1720      1730      1740

             1750      1760      1770      1780      1790      1800
pF1KE2 EKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVL
             1750      1760      1770      1780      1790      1800

             1810      1820      1830      1840      1850      1860
pF1KE2 QQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEFTGEDESSAH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEFTGEDESSAH
             1810      1820      1830      1840      1850      1860

             1870      1880                                        
pF1KE2 ALERKSDNPLDIAVTRLADLERNIERR---------------------------------
       :::::::::::::::::::::::::::                                 
XP_011 ALERKSDNPLDIAVTRLADLERNIERRYLKSPLSTTIQIKLDNVGTVTVPAPAPSVSGDG
             1870      1880      1890      1900      1910      1920

        1890      1900      1910      1920      1930      1940     
pF1KE2 --IEEDIAPGLRVWRRALSEARSAAQVALCIQQLQKSIAWEKSIMKVYCQICRKGDNEEL
         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGIEEDIAPGLRVWRRALSEARSAAQVALCIQQLQKSIAWEKSIMKVYCQICRKGDNEEL
             1930      1940      1950      1960      1970      1980

        1950      1960      1970      1980      1990      2000     
pF1KE2 LLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKGKKTNESKKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKGKKTNESKKG
             1990      2000      2010      2020      2030      2040

        2010      2020      2030      2040      2050      2060     
pF1KE2 KKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEENTSINLSKQESFTSVKKPKRDDSKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEENTSINLSKQESFTSVKKPKRDDSKD
             2050      2060      2070      2080      2090      2100

        2070      2080      2090      2100      2110      2120     
pF1KE2 LALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSSGQYPNLETF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSSGQYPNLETF
             2110      2120      2130      2140      2150      2160

        2130      2140      2150      2160                         
pF1KE2 ALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKKWTDTFKVS                 
       ::::::::::::::::::::::::::::::::::::::::                    
XP_011 ALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKKWTDTFKPLCYEDALAAQPYGAANSY
             2170      2180      2190      2200      2210      2220

XP_011 HQLTSPVPEAS
             2230 

>>NP_001276904 (OMIM: 605683) bromodomain adjacent to zi  (2132 aa)
 initn: 9955 init1: 8903 opt: 8992  Z-score: 3750.5  bits: 707.7 E(85289): 3.7e-202
Smith-Waterman score: 13879; 98.3% identity (98.3% similar) in 2168 aa overlap (1-2168:1-2132)

               10        20        30        40        50        60
pF1KE2 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
       :::::::::::::::::::::::::::::::::::::::::::::::::::  :::::::
NP_001 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFP--EWWRTTD
               70        80        90       100       110          

              130       140       150       160       170       180
pF1KE2 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
      120       130       140       150       160       170        

              190       200       210       220       230       240
pF1KE2 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
      180       190       200       210       220       230        

              250       260       270       280       290       300
pF1KE2 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
      240       250       260       270       280       290        

              310       320       330       340       350       360
pF1KE2 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
      300       310       320       330       340       350        

              370       380       390       400       410       420
pF1KE2 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
      360       370       380       390       400       410        

              430       440       450       460       470       480
pF1KE2 SSLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
       : ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
      420       430       440       450       460       470        

              490       500       510       520       530       540
pF1KE2 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
      480       490       500       510       520       530        

              550       560       570       580       590       600
pF1KE2 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
      540       550       560       570       580       590        

              610       620       630       640       650       660
pF1KE2 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
      600       610       620       630       640       650        

              670       680       690       700       710       720
pF1KE2 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
      660       670       680       690       700       710        

              730       740       750       760       770       780
pF1KE2 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
      720       730       740       750       760       770        

              790       800       810       820       830       840
pF1KE2 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
       ::::::::                                  ::::::::::::::::::
NP_001 RQYPEVIK----------------------------------GMQWCLLKEEDVIPRIRA
      780                                         790       800    

              850       860       870       880       890       900
pF1KE2 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
          810       820       830       840       850       860    

              910       920       930       940       950       960
pF1KE2 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
          870       880       890       900       910       920    

              970       980       990      1000      1010      1020
pF1KE2 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQERERRRQHMMLMKAMEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQERERRRQHMMLMKAMEA
          930       940       950       960       970       980    

             1030      1040      1050      1060      1070      1080
pF1KE2 RKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQKPLPELPRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQKPLPELPRI
          990      1000      1010      1020      1030      1040    

             1090      1100      1110      1120      1130      1140
pF1KE2 PGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDSMGEVQDLLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDSMGEVQDLLV
         1050      1060      1070      1080      1090      1100    

             1150      1160      1170      1180      1190      1200
pF1KE2 RLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQTELTESLKTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQTELTESLKTK
         1110      1120      1130      1140      1150      1160    

             1210      1220      1230      1240      1250      1260
pF1KE2 AFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGKLRKLRIIHA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGKLRKLRIIHA
         1170      1180      1190      1200      1210      1220    

             1270      1280      1290      1300      1310      1320
pF1KE2 KKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQGDEDDEDEED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQGDEDDEDEED
         1230      1240      1250      1260      1270      1280    

             1330      1340      1350      1360      1370      1380
pF1KE2 KEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHSLRSVMFGQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHSLRSVMFGQD
         1290      1300      1310      1320      1330      1340    

             1390      1400      1410      1420      1430      1440
pF1KE2 RYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNCSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNCSN
         1350      1360      1370      1380      1390      1400    

             1450      1460      1470      1480      1490      1500
pF1KE2 TDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNAGANGCTLSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNAGANGCTLSY
         1410      1420      1430      1440      1450      1460    

             1510      1520      1530      1540      1550      1560
pF1KE2 QNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWF
         1470      1480      1490      1500      1510      1520    

             1570      1580      1590      1600      1610      1620
pF1KE2 SLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPL
         1530      1540      1550      1560      1570      1580    

             1630      1640      1650      1660      1670      1680
pF1KE2 QVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTSNVASSKSES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTSNVASSKSES
         1590      1600      1610      1620      1630      1640    

             1690      1700      1710      1720      1730      1740
pF1KE2 PVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIR
         1650      1660      1670      1680      1690      1700    

             1750      1760      1770      1780      1790      1800
pF1KE2 EKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVL
         1710      1720      1730      1740      1750      1760    

             1810      1820      1830      1840      1850      1860
pF1KE2 QQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEFTGEDESSAH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEFTGEDESSAH
         1770      1780      1790      1800      1810      1820    

             1870      1880      1890      1900      1910      1920
pF1KE2 ALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSAAQVALCIQQLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSAAQVALCIQQLQ
         1830      1840      1850      1860      1870      1880    

             1930      1940      1950      1960      1970      1980
pF1KE2 KSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIA
         1890      1900      1910      1920      1930      1940    

             1990      2000      2010      2020      2030      2040
pF1KE2 KASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEE
         1950      1960      1970      1980      1990      2000    

             2050      2060      2070      2080      2090      2100
pF1KE2 NTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKV
         2010      2020      2030      2040      2050      2060    

             2110      2120      2130      2140      2150      2160
pF1KE2 IKKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKK
         2070      2080      2090      2100      2110      2120    

               
pF1KE2 WTDTFKVS
       ::::::::
NP_001 WTDTFKVS
         2130  

>>XP_011509344 (OMIM: 605683) PREDICTED: bromodomain adj  (2207 aa)
 initn: 7776 init1: 7776 opt: 8229  Z-score: 3433.5  bits: 649.1 E(85289): 1.6e-184
Smith-Waterman score: 14171; 99.4% identity (99.4% similar) in 2177 aa overlap (1-2166:1-2177)

               10        20        30        40        50        60
pF1KE2 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE2 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE2 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE2 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE2 SSLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
       : ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE2 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE2 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE2 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE2 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE2 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE2 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE2 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE2 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
              910       920       930       940       950       960

              970       980       990      1000                    
pF1KE2 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQE-----------RERRR
       ::::::::::::::::::::::::::::::::::::::::::::           :::::
XP_011 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQELERHRLDMVWERERRR
              970       980       990      1000      1010      1020

    1010      1020      1030      1040      1050      1060         
pF1KE2 QHMMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QHMMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLA
             1030      1040      1050      1060      1070      1080

    1070      1080      1090      1100      1110      1120         
pF1KE2 DQKPLPELPRIPGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DQKPLPELPRIPGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIG
             1090      1100      1110      1120      1130      1140

    1130      1140      1150      1160      1170      1180         
pF1KE2 DSMGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSMGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCG
             1150      1160      1170      1180      1190      1200

    1190      1200      1210      1220      1230      1240         
pF1KE2 QTELTESLKTKAFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTELTESLKTKAFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVE
             1210      1220      1230      1240      1250      1260

    1250      1260      1270      1280      1290      1300         
pF1KE2 GKLRKLRIIHAKKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKLRKLRIIHAKKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDD
             1270      1280      1290      1300      1310      1320

    1310      1320      1330      1340      1350      1360         
pF1KE2 QGDEDDEDEEDKEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGDEDDEDEEDKEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDAS
             1330      1340      1350      1360      1370      1380

    1370      1380      1390      1400      1410      1420         
pF1KE2 HSLRSVMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSLRSVMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMF
             1390      1400      1410      1420      1430      1440

    1430      1440      1450      1460      1470      1480         
pF1KE2 ETSGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETSGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKP
             1450      1460      1470      1480      1490      1500

    1490      1500      1510      1520      1530      1540         
pF1KE2 NAGANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NAGANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLL
             1510      1520      1530      1540      1550      1560

    1550      1560      1570      1580      1590      1600         
pF1KE2 KTLTEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTLTEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNP
             1570      1580      1590      1600      1610      1620

    1610      1620      1630      1640      1650      1660         
pF1KE2 VGLNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGLNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFL
             1630      1640      1650      1660      1670      1680

    1670      1680      1690      1700      1710      1720         
pF1KE2 TSNVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSNVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKA
             1690      1700      1710      1720      1730      1740

    1730      1740      1750      1760      1770      1780         
pF1KE2 LLKVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLKVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVE
             1750      1760      1770      1780      1790      1800

    1790      1800      1810      1820      1830      1840         
pF1KE2 EQAMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQAMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDG
             1810      1820      1830      1840      1850      1860

    1850      1860      1870      1880      1890      1900         
pF1KE2 EFTGEDESSAHALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFTGEDESSAHALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSA
             1870      1880      1890      1900      1910      1920

    1910      1920      1930      1940      1950      1960         
pF1KE2 AQVALCIQQLQKSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQVALCIQQLQKSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIP
             1930      1940      1950      1960      1970      1980

    1970      1980      1990      2000      2010      2020         
pF1KE2 DGDWFCPACIAKASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGDWFCPACIAKASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRG
             1990      2000      2010      2020      2030      2040

    2030      2040      2050      2060      2070      2080         
pF1KE2 NKDLKKRKMEENTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKDLKKRKMEENTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPV
             2050      2060      2070      2080      2090      2100

    2090      2100      2110      2120      2130      2140         
pF1KE2 NLKLVPGYKKVIKKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLKLVPGYKKVIKKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRA
             2110      2120      2130      2140      2150      2160

    2150      2160                                    
pF1KE2 GHNMRKYFEKKWTDTFKVS                            
       :::::::::::::::::                              
XP_011 GHNMRKYFEKKWTDTFKPLCYEDALAAQPYGAANSYHQLTSPVPEAS
             2170      2180      2190      2200       

>>XP_011509353 (OMIM: 605683) PREDICTED: bromodomain adj  (2141 aa)
 initn: 12088 init1: 7747 opt: 7994  Z-score: 3336.2  bits: 631.0 E(85289): 4.4e-179
Smith-Waterman score: 13851; 97.9% identity (97.9% similar) in 2177 aa overlap (1-2168:1-2141)

               10        20        30        40        50        60
pF1KE2 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
       :::::::::::::::::::::::::::::::::::::::::::::::::::  :::::::
XP_011 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFP--EWWRTTD
               70        80        90       100       110          

              130       140       150       160       170       180
pF1KE2 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
      120       130       140       150       160       170        

              190       200       210       220       230       240
pF1KE2 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
      180       190       200       210       220       230        

              250       260       270       280       290       300
pF1KE2 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
      240       250       260       270       280       290        

              310       320       330       340       350       360
pF1KE2 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
      300       310       320       330       340       350        

              370       380       390       400       410       420
pF1KE2 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
      360       370       380       390       400       410        

              430       440       450       460       470       480
pF1KE2 SSLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
       : ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
      420       430       440       450       460       470        

              490       500       510       520       530       540
pF1KE2 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
      480       490       500       510       520       530        

              550       560       570       580       590       600
pF1KE2 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
      540       550       560       570       580       590        

              610       620       630       640       650       660
pF1KE2 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
      600       610       620       630       640       650        

              670       680       690       700       710       720
pF1KE2 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
      660       670       680       690       700       710        

              730       740       750       760       770       780
pF1KE2 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
      720       730       740       750       760       770        

              790       800       810       820       830       840
pF1KE2 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
       ::::::::                                  ::::::::::::::::::
XP_011 RQYPEVIK----------------------------------GMQWCLLKEEDVIPRIRA
      780                                         790       800    

              850       860       870       880       890       900
pF1KE2 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
          810       820       830       840       850       860    

              910       920       930       940       950       960
pF1KE2 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
          870       880       890       900       910       920    

              970       980       990      1000               1010 
pF1KE2 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQE---------RERRRQH
       ::::::::::::::::::::::::::::::::::::::::::::         :::::::
XP_011 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQELERHRLDMERERRRQH
          930       940       950       960       970       980    

            1020      1030      1040      1050      1060      1070 
pF1KE2 MMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQ
          990      1000      1010      1020      1030      1040    

            1080      1090      1100      1110      1120      1130 
pF1KE2 KPLPELPRIPGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPLPELPRIPGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDS
         1050      1060      1070      1080      1090      1100    

            1140      1150      1160      1170      1180      1190 
pF1KE2 MGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQT
         1110      1120      1130      1140      1150      1160    

            1200      1210      1220      1230      1240      1250 
pF1KE2 ELTESLKTKAFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELTESLKTKAFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGK
         1170      1180      1190      1200      1210      1220    

            1260      1270      1280      1290      1300      1310 
pF1KE2 LRKLRIIHAKKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRKLRIIHAKKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQG
         1230      1240      1250      1260      1270      1280    

            1320      1330      1340      1350      1360      1370 
pF1KE2 DEDDEDEEDKEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DEDDEDEEDKEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHS
         1290      1300      1310      1320      1330      1340    

            1380      1390      1400      1410      1420      1430 
pF1KE2 LRSVMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRSVMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFET
         1350      1360      1370      1380      1390      1400    

            1440      1450      1460      1470      1480      1490 
pF1KE2 SGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNA
         1410      1420      1430      1440      1450      1460    

            1500      1510      1520      1530      1540      1550 
pF1KE2 GANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKT
         1470      1480      1490      1500      1510      1520    

            1560      1570      1580      1590      1600      1610 
pF1KE2 LTEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVG
         1530      1540      1550      1560      1570      1580    

            1620      1630      1640      1650      1660      1670 
pF1KE2 LNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTS
         1590      1600      1610      1620      1630      1640    

            1680      1690      1700      1710      1720      1730 
pF1KE2 NVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALL
         1650      1660      1670      1680      1690      1700    

            1740      1750      1760      1770      1780      1790 
pF1KE2 KVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQ
         1710      1720      1730      1740      1750      1760    

            1800      1810      1820      1830      1840      1850 
pF1KE2 AMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEF
         1770      1780      1790      1800      1810      1820    

            1860      1870      1880      1890      1900      1910 
pF1KE2 TGEDESSAHALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSAAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGEDESSAHALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSAAQ
         1830      1840      1850      1860      1870      1880    

            1920      1930      1940      1950      1960      1970 
pF1KE2 VALCIQQLQKSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VALCIQQLQKSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDG
         1890      1900      1910      1920      1930      1940    

            1980      1990      2000      2010      2020      2030 
pF1KE2 DWFCPACIAKASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DWFCPACIAKASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNK
         1950      1960      1970      1980      1990      2000    

            2040      2050      2060      2070      2080      2090 
pF1KE2 DLKKRKMEENTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLKKRKMEENTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNL
         2010      2020      2030      2040      2050      2060    

            2100      2110      2120      2130      2140      2150 
pF1KE2 KLVPGYKKVIKKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLVPGYKKVIKKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGH
         2070      2080      2090      2100      2110      2120    

            2160        
pF1KE2 NMRKYFEKKWTDTFKVS
       :::::::::::::::::
XP_011 NMRKYFEKKWTDTFKVS
         2130      2140 

>>NP_001316787 (OMIM: 605683) bromodomain adjacent to zi  (2143 aa)
 initn: 12816 init1: 7747 opt: 7986  Z-score: 3332.8  bits: 630.4 E(85289): 6.7e-179
Smith-Waterman score: 13878; 98.0% identity (98.0% similar) in 2177 aa overlap (1-2168:1-2143)

               10        20        30        40        50        60
pF1KE2 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE2 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE2 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE2 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE2 SSLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
       : ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE2 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE2 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE2 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE2 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE2 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE2 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
       ::::::::                                  ::::::::::::::::::
NP_001 RQYPEVIK----------------------------------GMQWCLLKEEDVIPRIRA
                                                790       800      

              850       860       870       880       890       900
pF1KE2 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
        810       820       830       840       850       860      

              910       920       930       940       950       960
pF1KE2 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
        870       880       890       900       910       920      

              970       980       990      1000               1010 
pF1KE2 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQE---------RERRRQH
       ::::::::::::::::::::::::::::::::::::::::::::         :::::::
NP_001 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQELERHRLDMERERRRQH
        930       940       950       960       970       980      

            1020      1030      1040      1050      1060      1070 
pF1KE2 MMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQ
        990      1000      1010      1020      1030      1040      

            1080      1090      1100      1110      1120      1130 
pF1KE2 KPLPELPRIPGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPLPELPRIPGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDS
       1050      1060      1070      1080      1090      1100      

            1140      1150      1160      1170      1180      1190 
pF1KE2 MGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQT
       1110      1120      1130      1140      1150      1160      

            1200      1210      1220      1230      1240      1250 
pF1KE2 ELTESLKTKAFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELTESLKTKAFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGK
       1170      1180      1190      1200      1210      1220      

            1260      1270      1280      1290      1300      1310 
pF1KE2 LRKLRIIHAKKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRKLRIIHAKKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQG
       1230      1240      1250      1260      1270      1280      

            1320      1330      1340      1350      1360      1370 
pF1KE2 DEDDEDEEDKEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DEDDEDEEDKEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHS
       1290      1300      1310      1320      1330      1340      

            1380      1390      1400      1410      1420      1430 
pF1KE2 LRSVMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRSVMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFET
       1350      1360      1370      1380      1390      1400      

            1440      1450      1460      1470      1480      1490 
pF1KE2 SGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNA
       1410      1420      1430      1440      1450      1460      

            1500      1510      1520      1530      1540      1550 
pF1KE2 GANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKT
       1470      1480      1490      1500      1510      1520      

            1560      1570      1580      1590      1600      1610 
pF1KE2 LTEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVG
       1530      1540      1550      1560      1570      1580      

            1620      1630      1640      1650      1660      1670 
pF1KE2 LNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTS
       1590      1600      1610      1620      1630      1640      

            1680      1690      1700      1710      1720      1730 
pF1KE2 NVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALL
       1650      1660      1670      1680      1690      1700      

            1740      1750      1760      1770      1780      1790 
pF1KE2 KVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQ
       1710      1720      1730      1740      1750      1760      

            1800      1810      1820      1830      1840      1850 
pF1KE2 AMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEF
       1770      1780      1790      1800      1810      1820      

            1860      1870      1880      1890      1900      1910 
pF1KE2 TGEDESSAHALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSAAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGEDESSAHALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSAAQ
       1830      1840      1850      1860      1870      1880      

            1920      1930      1940      1950      1960      1970 
pF1KE2 VALCIQQLQKSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VALCIQQLQKSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDG
       1890      1900      1910      1920      1930      1940      

            1980      1990      2000      2010      2020      2030 
pF1KE2 DWFCPACIAKASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DWFCPACIAKASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNK
       1950      1960      1970      1980      1990      2000      

            2040      2050      2060      2070      2080      2090 
pF1KE2 DLKKRKMEENTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLKKRKMEENTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNL
       2010      2020      2030      2040      2050      2060      

            2100      2110      2120      2130      2140      2150 
pF1KE2 KLVPGYKKVIKKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLVPGYKKVIKKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGH
       2070      2080      2090      2100      2110      2120      

            2160        
pF1KE2 NMRKYFEKKWTDTFKVS
       :::::::::::::::::
NP_001 NMRKYFEKKWTDTFKVS
       2130      2140   

>>XP_011509345 (OMIM: 605683) PREDICTED: bromodomain adj  (2197 aa)
 initn: 8879 init1: 7007 opt: 7096  Z-score: 2963.2  bits: 562.1 E(85289): 2.6e-158
Smith-Waterman score: 13810; 96.8% identity (96.8% similar) in 2200 aa overlap (1-2165:1-2166)

               10        20        30        40        50        60
pF1KE2 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE2 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE2 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE2 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE2 SSLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
       : ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE2 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE2 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE2 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE2 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE2 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE2 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
       ::::::::                                  ::::::::::::::::::
XP_011 RQYPEVIK----------------------------------GMQWCLLKEEDVIPRIRA
                                                790       800      

              850       860       870       880       890       900
pF1KE2 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
        810       820       830       840       850       860      

              910       920       930       940       950       960
pF1KE2 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
        870       880       890       900       910       920      

              970       980       990      1000      1010      1020
pF1KE2 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQERERRRQHMMLMKAMEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQERERRRQHMMLMKAMEA
        930       940       950       960       970       980      

             1030      1040      1050      1060      1070      1080
pF1KE2 RKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQKPLPELPRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQKPLPELPRI
        990      1000      1010      1020      1030      1040      

             1090      1100      1110      1120      1130      1140
pF1KE2 PGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDSMGEVQDLLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDSMGEVQDLLV
       1050      1060      1070      1080      1090      1100      

             1150      1160      1170      1180      1190      1200
pF1KE2 RLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQTELTESLKTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQTELTESLKTK
       1110      1120      1130      1140      1150      1160      

             1210      1220      1230      1240      1250      1260
pF1KE2 AFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGKLRKLRIIHA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGKLRKLRIIHA
       1170      1180      1190      1200      1210      1220      

             1270      1280      1290      1300      1310      1320
pF1KE2 KKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQGDEDDEDEED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQGDEDDEDEED
       1230      1240      1250      1260      1270      1280      

             1330      1340      1350      1360      1370      1380
pF1KE2 KEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHSLRSVMFGQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHSLRSVMFGQD
       1290      1300      1310      1320      1330      1340      

             1390      1400      1410      1420      1430      1440
pF1KE2 RYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNCSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNCSN
       1350      1360      1370      1380      1390      1400      

             1450      1460      1470      1480      1490      1500
pF1KE2 TDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNAGANGCTLSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNAGANGCTLSY
       1410      1420      1430      1440      1450      1460      

             1510      1520      1530      1540      1550      1560
pF1KE2 QNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWF
       1470      1480      1490      1500      1510      1520      

             1570      1580      1590      1600      1610      1620
pF1KE2 SLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPL
       1530      1540      1550      1560      1570      1580      

             1630      1640      1650      1660      1670      1680
pF1KE2 QVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTSNVASSKSES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTSNVASSKSES
       1590      1600      1610      1620      1630      1640      

             1690      1700      1710      1720      1730      1740
pF1KE2 PVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIR
       1650      1660      1670      1680      1690      1700      

             1750      1760      1770      1780      1790      1800
pF1KE2 EKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVL
       1710      1720      1730      1740      1750      1760      

             1810      1820      1830      1840      1850      1860
pF1KE2 QQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEFTGEDESSAH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEFTGEDESSAH
       1770      1780      1790      1800      1810      1820      

             1870      1880                                        
pF1KE2 ALERKSDNPLDIAVTRLADLERNIERR---------------------------------
       :::::::::::::::::::::::::::                                 
XP_011 ALERKSDNPLDIAVTRLADLERNIERRYLKSPLSTTIQIKLDNVGTVTVPAPAPSVSGDG
       1830      1840      1850      1860      1870      1880      

        1890      1900      1910      1920      1930      1940     
pF1KE2 --IEEDIAPGLRVWRRALSEARSAAQVALCIQQLQKSIAWEKSIMKVYCQICRKGDNEEL
         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGIEEDIAPGLRVWRRALSEARSAAQVALCIQQLQKSIAWEKSIMKVYCQICRKGDNEEL
       1890      1900      1910      1920      1930      1940      

        1950      1960      1970      1980      1990      2000     
pF1KE2 LLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKGKKTNESKKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKGKKTNESKKG
       1950      1960      1970      1980      1990      2000      

        2010      2020      2030      2040      2050      2060     
pF1KE2 KKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEENTSINLSKQESFTSVKKPKRDDSKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEENTSINLSKQESFTSVKKPKRDDSKD
       2010      2020      2030      2040      2050      2060      

        2070      2080      2090      2100      2110      2120     
pF1KE2 LALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSSGQYPNLETF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSSGQYPNLETF
       2070      2080      2090      2100      2110      2120      

        2130      2140      2150      2160                         
pF1KE2 ALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKKWTDTFKVS                 
       ::::::::::::::::::::::::::::::::::::::::                    
XP_011 ALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKKWTDTFKPLCYEDALAAQPYGAANSY
       2130      2140      2150      2160      2170      2180      

XP_011 HQLTSPVPEAS
       2190       

>>XP_016859412 (OMIM: 605683) PREDICTED: bromodomain adj  (2212 aa)
 initn: 8598 init1: 6495 opt: 6655  Z-score: 2780.1  bits: 528.2 E(85289): 4.1e-148
Smith-Waterman score: 14022; 98.0% identity (98.0% similar) in 2200 aa overlap (1-2156:1-2200)

               10        20        30        40        50        60
pF1KE2 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE2 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE2 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE2 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE2 SSLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
       : ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE2 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE2 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE2 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE2 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE2 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE2 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE2 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE2 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
              910       920       930       940       950       960

              970       980       990      1000               1010 
pF1KE2 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQE---------RERRRQH
       ::::::::::::::::::::::::::::::::::::::::::::         :::::::
XP_016 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQELERHRLDMERERRRQH
              970       980       990      1000      1010      1020

            1020      1030      1040      1050      1060      1070 
pF1KE2 MMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQ
             1030      1040      1050      1060      1070      1080

            1080      1090      1100      1110      1120      1130 
pF1KE2 KPLPELPRIPGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPLPELPRIPGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDS
             1090      1100      1110      1120      1130      1140

            1140      1150      1160      1170      1180      1190 
pF1KE2 MGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQT
             1150      1160      1170      1180      1190      1200

            1200      1210      1220      1230      1240      1250 
pF1KE2 ELTESLKTKAFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELTESLKTKAFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGK
             1210      1220      1230      1240      1250      1260

            1260      1270      1280      1290      1300      1310 
pF1KE2 LRKLRIIHAKKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRKLRIIHAKKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQG
             1270      1280      1290      1300      1310      1320

            1320      1330      1340      1350      1360      1370 
pF1KE2 DEDDEDEEDKEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DEDDEDEEDKEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHS
             1330      1340      1350      1360      1370      1380

            1380      1390      1400      1410      1420      1430 
pF1KE2 LRSVMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRSVMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFET
             1390      1400      1410      1420      1430      1440

            1440      1450      1460      1470      1480      1490 
pF1KE2 SGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNA
             1450      1460      1470      1480      1490      1500

            1500      1510      1520      1530      1540      1550 
pF1KE2 GANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKT
             1510      1520      1530      1540      1550      1560

            1560      1570      1580      1590      1600      1610 
pF1KE2 LTEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVG
             1570      1580      1590      1600      1610      1620

            1620      1630      1640      1650      1660      1670 
pF1KE2 LNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTS
             1630      1640      1650      1660      1670      1680

            1680      1690      1700      1710      1720      1730 
pF1KE2 NVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALL
             1690      1700      1710      1720      1730      1740

            1740      1750      1760      1770      1780      1790 
pF1KE2 KVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQ
             1750      1760      1770      1780      1790      1800

            1800      1810      1820      1830      1840      1850 
pF1KE2 AMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEF
             1810      1820      1830      1840      1850      1860

            1860      1870      1880                               
pF1KE2 TGEDESSAHALERKSDNPLDIAVTRLADLERNIERR------------------------
       ::::::::::::::::::::::::::::::::::::                        
XP_016 TGEDESSAHALERKSDNPLDIAVTRLADLERNIERRYLKSPLSTTIQIKLDNVGTVTVPA
             1870      1880      1890      1900      1910      1920

                 1890      1900      1910      1920      1930      
pF1KE2 -----------IEEDIAPGLRVWRRALSEARSAAQVALCIQQLQKSIAWEKSIMKVYCQI
                  :::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAPSVSGDGDGIEEDIAPGLRVWRRALSEARSAAQVALCIQQLQKSIAWEKSIMKVYCQI
             1930      1940      1950      1960      1970      1980

       1940      1950      1960      1970      1980      1990      
pF1KE2 CRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKG
             1990      2000      2010      2020      2030      2040

       2000      2010      2020      2030      2040      2050      
pF1KE2 KKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEENTSINLSKQESFTSVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEENTSINLSKQESFTSVK
             2050      2060      2070      2080      2090      2100

       2060      2070      2080      2090      2100      2110      
pF1KE2 KPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSS
             2110      2120      2130      2140      2150      2160

       2120      2130      2140      2150      2160        
pF1KE2 GQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKKWTDTFKVS
       ::::::::::::::::::::::::::::::::::::::::            
XP_016 GQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKKWTDTFKVS
             2170      2180      2190      2200      2210  

>>XP_011509340 (OMIM: 605683) PREDICTED: bromodomain adj  (2240 aa)
 initn: 8588 init1: 6495 opt: 6655  Z-score: 2780.1  bits: 528.2 E(85289): 4.1e-148
Smith-Waterman score: 14022; 98.0% identity (98.0% similar) in 2200 aa overlap (1-2156:1-2200)

               10        20        30        40        50        60
pF1KE2 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE2 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE2 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE2 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE2 SSLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
       : ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE2 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE2 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE2 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE2 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE2 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE2 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE2 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE2 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
              910       920       930       940       950       960

              970       980       990      1000               1010 
pF1KE2 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQE---------RERRRQH
       ::::::::::::::::::::::::::::::::::::::::::::         :::::::
XP_011 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQELERHRLDMERERRRQH
              970       980       990      1000      1010      1020

            1020      1030      1040      1050      1060      1070 
pF1KE2 MMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQ
             1030      1040      1050      1060      1070      1080

            1080      1090      1100      1110      1120      1130 
pF1KE2 KPLPELPRIPGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPLPELPRIPGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDS
             1090      1100      1110      1120      1130      1140

            1140      1150      1160      1170      1180      1190 
pF1KE2 MGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQT
             1150      1160      1170      1180      1190      1200

            1200      1210      1220      1230      1240      1250 
pF1KE2 ELTESLKTKAFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELTESLKTKAFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGK
             1210      1220      1230      1240      1250      1260

            1260      1270      1280      1290      1300      1310 
pF1KE2 LRKLRIIHAKKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRKLRIIHAKKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQG
             1270      1280      1290      1300      1310      1320

            1320      1330      1340      1350      1360      1370 
pF1KE2 DEDDEDEEDKEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DEDDEDEEDKEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHS
             1330      1340      1350      1360      1370      1380

            1380      1390      1400      1410      1420      1430 
pF1KE2 LRSVMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRSVMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFET
             1390      1400      1410      1420      1430      1440

            1440      1450      1460      1470      1480      1490 
pF1KE2 SGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNA
             1450      1460      1470      1480      1490      1500

            1500      1510      1520      1530      1540      1550 
pF1KE2 GANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKT
             1510      1520      1530      1540      1550      1560

            1560      1570      1580      1590      1600      1610 
pF1KE2 LTEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVG
             1570      1580      1590      1600      1610      1620

            1620      1630      1640      1650      1660      1670 
pF1KE2 LNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTS
             1630      1640      1650      1660      1670      1680

            1680      1690      1700      1710      1720      1730 
pF1KE2 NVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALL
             1690      1700      1710      1720      1730      1740

            1740      1750      1760      1770      1780      1790 
pF1KE2 KVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQ
             1750      1760      1770      1780      1790      1800

            1800      1810      1820      1830      1840      1850 
pF1KE2 AMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEF
             1810      1820      1830      1840      1850      1860

            1860      1870      1880                               
pF1KE2 TGEDESSAHALERKSDNPLDIAVTRLADLERNIERR------------------------
       ::::::::::::::::::::::::::::::::::::                        
XP_011 TGEDESSAHALERKSDNPLDIAVTRLADLERNIERRYLKSPLSTTIQIKLDNVGTVTVPA
             1870      1880      1890      1900      1910      1920

                 1890      1900      1910      1920      1930      
pF1KE2 -----------IEEDIAPGLRVWRRALSEARSAAQVALCIQQLQKSIAWEKSIMKVYCQI
                  :::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PAPSVSGDGDGIEEDIAPGLRVWRRALSEARSAAQVALCIQQLQKSIAWEKSIMKVYCQI
             1930      1940      1950      1960      1970      1980

       1940      1950      1960      1970      1980      1990      
pF1KE2 CRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKG
             1990      2000      2010      2020      2030      2040

       2000      2010      2020      2030      2040      2050      
pF1KE2 KKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEENTSINLSKQESFTSVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEENTSINLSKQESFTSVK
             2050      2060      2070      2080      2090      2100

       2060      2070      2080      2090      2100      2110      
pF1KE2 KPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSS
             2110      2120      2130      2140      2150      2160

       2120      2130      2140      2150      2160                
pF1KE2 GQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKKWTDTFKVS        
       ::::::::::::::::::::::::::::::::::::::::                    
XP_011 GQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKKWTDTFKPLCYEDALAA
             2170      2180      2190      2200      2210      2220

XP_011 QPYGAANSYHQLTSPVPEAS
             2230      2240

>>XP_011509356 (OMIM: 605683) PREDICTED: bromodomain adj  (1976 aa)
 initn: 12632 init1: 6541 opt: 6629  Z-score: 2770.0  bits: 526.2 E(85289): 1.5e-147
Smith-Waterman score: 12295; 96.8% identity (97.7% similar) in 1960 aa overlap (1-1941:1-1960)

               10        20        30        40        50        60
pF1KE2 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE2 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE2 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE2 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE2 SSLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
       : ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE2 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE2 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE2 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE2 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE2 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE2 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE2 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE2 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
              910       920       930       940       950       960

              970       980       990      1000                    
pF1KE2 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQE-----------RERRR
       ::::::::::::::::::::::::::::::::::::::::::::           :::::
XP_011 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQELERHRLDMVWERERRR
              970       980       990      1000      1010      1020

    1010      1020      1030      1040      1050      1060         
pF1KE2 QHMMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QHMMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLA
             1030      1040      1050      1060      1070      1080

    1070      1080      1090      1100      1110      1120         
pF1KE2 DQKPLPELPRIPGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DQKPLPELPRIPGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIG
             1090      1100      1110      1120      1130      1140

    1130      1140      1150      1160      1170      1180         
pF1KE2 DSMGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSMGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCG
             1150      1160      1170      1180      1190      1200

    1190      1200      1210      1220      1230      1240         
pF1KE2 QTELTESLKTKAFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTELTESLKTKAFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVE
             1210      1220      1230      1240      1250      1260

    1250      1260      1270      1280      1290      1300         
pF1KE2 GKLRKLRIIHAKKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKLRKLRIIHAKKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDD
             1270      1280      1290      1300      1310      1320

    1310      1320      1330      1340      1350      1360         
pF1KE2 QGDEDDEDEEDKEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGDEDDEDEEDKEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDAS
             1330      1340      1350      1360      1370      1380

    1370      1380      1390      1400      1410      1420         
pF1KE2 HSLRSVMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSLRSVMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMF
             1390      1400      1410      1420      1430      1440

    1430      1440      1450      1460      1470      1480         
pF1KE2 ETSGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETSGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKP
             1450      1460      1470      1480      1490      1500

    1490      1500      1510      1520      1530      1540         
pF1KE2 NAGANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NAGANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLL
             1510      1520      1530      1540      1550      1560

    1550      1560      1570      1580      1590      1600         
pF1KE2 KTLTEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTLTEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNP
             1570      1580      1590      1600      1610      1620

    1610      1620      1630      1640      1650      1660         
pF1KE2 VGLNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGLNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFL
             1630      1640      1650      1660      1670      1680

    1670      1680      1690      1700      1710      1720         
pF1KE2 TSNVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSNVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKA
             1690      1700      1710      1720      1730      1740

    1730      1740      1750      1760      1770      1780         
pF1KE2 LLKVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLKVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVE
             1750      1760      1770      1780      1790      1800

    1790      1800      1810      1820      1830      1840         
pF1KE2 EQAMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQAMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDG
             1810      1820      1830      1840      1850      1860

    1850      1860      1870      1880          1890      1900     
pF1KE2 EFTGEDESSAHALERKSDNPLDIAVTRLADLERNIERR----IEEDIAPGLRVWRRALSE
       :::::::::::::::::::::::::::::::::::::     .:..:  .   .  :...
XP_011 EFTGEDESSAHALERKSDNPLDIAVTRLADLERNIERSTAKSVEREIMKNCFFFVMAVTK
             1870      1880      1890      1900      1910      1920

        1910      1920          1930      1940      1950      1960 
pF1KE2 ARSAAQVALCIQQLQKSIAWEK----SIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCH
       :   . .   .:: :   .. .    ::. .: .  . ::                    
XP_011 AVIPTAIDPRLQQSQMETGFVQLALLSILAIYHSSSKLGDIRSVISFKPFYVSTAF    
             1930      1940      1950      1960      1970          

            1970      1980      1990      2000      2010      2020 
pF1KE2 RPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSAS




2168 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 19:04:01 2016 done: Sat Nov  5 19:04:05 2016
 Total Scan time: 24.630 Total Display time:  1.700

Function used was FASTA [36.3.4 Apr, 2011]
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