Result of FASTA (omim) for pF1KE1600
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE1600, 2231 aa
  1>>>pF1KE1600 2231 - 2231 aa - 2231 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 16.4435+/-0.000514; mu= -23.7530+/- 0.032
 mean_var=810.5030+/-167.017, 0's: 0 Z-trim(124.8): 296  B-trim: 0 in 0/59
 Lambda= 0.045050
 statistics sampled from 46920 (47272) to 46920 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.784), E-opt: 0.2 (0.554), width:  16
 Scan time: 20.610

The best scores are:                                      opt bits E(85289)
XP_005267126 (OMIM: 135900,614556,614562) PREDICTE (2289) 15560 1028.5       0
XP_016866593 (OMIM: 135900,614556,614562) PREDICTE (2316) 11536 767.0       0
XP_016866598 (OMIM: 135900,614556,614562) PREDICTE (1539) 10595 705.7 1.1e-201
XP_016866596 (OMIM: 135900,614556,614562) PREDICTE (2256) 10415 694.1 4.7e-198
XP_016866592 (OMIM: 135900,614556,614562) PREDICTE (2326) 9674 646.0 1.5e-183
XP_011534286 (OMIM: 135900,614556,614562) PREDICTE (2359) 9663 645.3 2.5e-183
XP_016866594 (OMIM: 135900,614556,614562) PREDICTE (2306) 9625 642.8 1.4e-182
XP_011534290 (OMIM: 135900,614556,614562) PREDICTE (1336) 9147 611.5 2.1e-173
XP_016866595 (OMIM: 135900,614556,614562) PREDICTE (2263) 8832 591.3 4.4e-167
NP_059989 (OMIM: 135900,614556,614562) AT-rich int (2236) 8763 586.8 9.8e-166
NP_065783 (OMIM: 135900,614556,614562) AT-rich int (2249) 8750 585.9 1.8e-165
XP_016866597 (OMIM: 135900,614556,614562) PREDICTE (1551) 4020 278.4 4.7e-73
NP_006006 (OMIM: 603024,614607) AT-rich interactiv (2285) 3826 265.9 3.9e-69
NP_624361 (OMIM: 603024,614607) AT-rich interactiv (2068) 3360 235.6 4.7e-60
NP_000079 (OMIM: 114000,120150,130000,130060,16620 (1464)  622 57.5 1.4e-06
XP_011522643 (OMIM: 114000,120150,130000,130060,16 (1398)  585 55.1   7e-06
NP_000081 (OMIM: 120180,130020,130050) collagen al (1466)  578 54.6 9.9e-06
XP_011508860 (OMIM: 120131,203780) PREDICTED: coll (1654)  548 52.7 4.2e-05
XP_016869755 (OMIM: 120215,130000) PREDICTED: coll (1715)  527 51.4 0.00011
NP_001265003 (OMIM: 120215,130000) collagen alpha- (1838)  527 51.4 0.00012
NP_000084 (OMIM: 120215,130000) collagen alpha-1(V (1838)  527 51.4 0.00012
XP_016874320 (OMIM: 108300,120140,132450,150600,15 (1305)  513 50.4 0.00017
NP_149162 (OMIM: 108300,120140,132450,150600,15121 (1418)  513 50.4 0.00018
XP_016874319 (OMIM: 108300,120140,132450,150600,15 (1465)  513 50.4 0.00019
NP_001835 (OMIM: 108300,120140,132450,150600,15121 (1487)  513 50.4 0.00019
XP_016874318 (OMIM: 108300,120140,132450,150600,15 (1534)  513 50.4 0.00019
XP_016874317 (OMIM: 108300,120140,132450,150600,15 (1535)  513 50.4 0.00019
XP_005246334 (OMIM: 104200,120070,141200,203780) P (1635)  505 49.9 0.00029
XP_011536691 (OMIM: 601234) PREDICTED: nascent pol (2078)  505 50.0 0.00034
XP_006719476 (OMIM: 601234) PREDICTED: nascent pol (2082)  505 50.0 0.00034
XP_006719477 (OMIM: 601234) PREDICTED: nascent pol (2082)  505 50.0 0.00034
XP_006719475 (OMIM: 601234) PREDICTED: nascent pol (2082)  505 50.0 0.00034
NP_872363 (OMIM: 609004) B-cell CLL/lymphoma 9-lik (1499)  497 49.4 0.00039
XP_006718878 (OMIM: 609004) PREDICTED: B-cell CLL/ (1499)  497 49.4 0.00039
XP_005271568 (OMIM: 609004) PREDICTED: B-cell CLL/ (1499)  497 49.4 0.00039
XP_016873063 (OMIM: 609004) PREDICTED: B-cell CLL/ (1513)  497 49.4 0.00039
XP_011541058 (OMIM: 609004) PREDICTED: B-cell CLL/ (1514)  497 49.4 0.00039
XP_016873062 (OMIM: 609004) PREDICTED: B-cell CLL/ (1544)  497 49.4  0.0004
XP_016873061 (OMIM: 609004) PREDICTED: B-cell CLL/ (1547)  497 49.4  0.0004
XP_005271570 (OMIM: 609004) PREDICTED: B-cell CLL/ (1462)  496 49.3  0.0004
XP_005271569 (OMIM: 609004) PREDICTED: B-cell CLL/ (1462)  496 49.3  0.0004
XP_016858786 (OMIM: 120131,203780) PREDICTED: coll (1651)  496 49.4 0.00044
XP_011508875 (OMIM: 120190,130000) PREDICTED: coll (1453)  486 48.7 0.00062
NP_000384 (OMIM: 120190,130000) collagen alpha-2(V (1499)  486 48.7 0.00064
XP_011508858 (OMIM: 104200,120070,141200,203780) P (1257)  469 47.5  0.0012
XP_011508857 (OMIM: 104200,120070,141200,203780) P (1609)  469 47.6  0.0014
NP_000082 (OMIM: 104200,120070,141200,203780) coll (1670)  469 47.6  0.0015
XP_011526344 (OMIM: 120216) PREDICTED: collagen al (1744)  468 47.6  0.0016
NP_056534 (OMIM: 120216) collagen alpha-3(V) chain (1745)  468 47.6  0.0016
XP_011508874 (OMIM: 120131,203780) PREDICTED: coll (1132)  451 46.3  0.0025


>>XP_005267126 (OMIM: 135900,614556,614562) PREDICTED: A  (2289 aa)
 initn: 15560 init1: 15560 opt: 15560  Z-score: 5483.8  bits: 1028.5 E(85289):    0
Smith-Waterman score: 15560; 100.0% identity (100.0% similar) in 2231 aa overlap (1-2231:59-2289)

                                             10        20        30
pF1KE1                               METGLLPNHKLKTVGEAPAAPPHQQHHHHH
                                     ::::::::::::::::::::::::::::::
XP_005 GSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHH
       30        40        50        60        70        80        

               40        50        60        70        80        90
pF1KE1 HAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAP
       90       100       110       120       130       140        

              100       110       120       130       140       150
pF1KE1 QPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGAL
      150       160       170       180       190       200        

              160       170       180       190       200       210
pF1KE1 GTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHS
      210       220       230       240       250       260        

              220       230       240       250       260       270
pF1KE1 ASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGG
      270       280       290       300       310       320        

              280       290       300       310       320       330
pF1KE1 AGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAA
      330       340       350       360       370       380        

              340       350       360       370       380       390
pF1KE1 SLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPP
      390       400       410       420       430       440        

              400       410       420       430       440       450
pF1KE1 PPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGP
      450       460       470       480       490       500        

              460       470       480       490       500       510
pF1KE1 TMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPG
      510       520       530       540       550       560        

              520       530       540       550       560       570
pF1KE1 AMAGMQYPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AMAGMQYPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQ
      570       580       590       600       610       620        

              580       590       600       610       620       630
pF1KE1 QDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVS
      630       640       650       660       670       680        

              640       650       660       670       680       690
pF1KE1 ASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPG
      690       700       710       720       730       740        

              700       710       720       730       740       750
pF1KE1 SQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPG
      750       760       770       780       790       800        

              760       770       780       790       800       810
pF1KE1 GQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQ
      810       820       830       840       850       860        

              820       830       840       850       860       870
pF1KE1 MHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRK
      870       880       890       900       910       920        

              880       890       900       910       920       930
pF1KE1 AQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAP
      930       940       950       960       970       980        

              940       950       960       970       980       990
pF1KE1 AMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGN
      990      1000      1010      1020      1030      1040        

             1000      1010      1020      1030      1040      1050
pF1KE1 LPVPSPMSPSSASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LPVPSPMSPSSASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPE
     1050      1060      1070      1080      1090      1100        

             1060      1070      1080      1090      1100      1110
pF1KE1 RKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATN
     1110      1120      1130      1140      1150      1160        

             1120      1130      1140      1150      1160      1170
pF1KE1 LNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGS
     1170      1180      1190      1200      1210      1220        

             1180      1190      1200      1210      1220      1230
pF1KE1 LQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSF
     1230      1240      1250      1260      1270      1280        

             1240      1250      1260      1270      1280      1290
pF1KE1 PKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQD
     1290      1300      1310      1320      1330      1340        

             1300      1310      1320      1330      1340      1350
pF1KE1 MYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQ
     1350      1360      1370      1380      1390      1400        

             1360      1370      1380      1390      1400      1410
pF1KE1 QPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYS
     1410      1420      1430      1440      1450      1460        

             1420      1430      1440      1450      1460      1470
pF1KE1 RERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAP
     1470      1480      1490      1500      1510      1520        

             1480      1490      1500      1510      1520      1530
pF1KE1 PYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPN
     1530      1540      1550      1560      1570      1580        

             1540      1550      1560      1570      1580      1590
pF1KE1 HISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITF
     1590      1600      1610      1620      1630      1640        

             1600      1610      1620      1630      1640      1650
pF1KE1 PPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTV
     1650      1660      1670      1680      1690      1700        

             1660      1670      1680      1690      1700      1710
pF1KE1 ATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDS
     1710      1720      1730      1740      1750      1760        

             1720      1730      1740      1750      1760      1770
pF1KE1 GKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLP
     1770      1780      1790      1800      1810      1820        

             1780      1790      1800      1810      1820      1830
pF1KE1 IKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPP
     1830      1840      1850      1860      1870      1880        

             1840      1850      1860      1870      1880      1890
pF1KE1 PLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQ
     1890      1900      1910      1920      1930      1940        

             1900      1910      1920      1930      1940      1950
pF1KE1 QAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKH
     1950      1960      1970      1980      1990      2000        

             1960      1970      1980      1990      2000      2010
pF1KE1 PGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTL
     2010      2020      2030      2040      2050      2060        

             2020      2030      2040      2050      2060      2070
pF1KE1 ANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCK
     2070      2080      2090      2100      2110      2120        

             2080      2090      2100      2110      2120      2130
pF1KE1 LSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARA
     2130      2140      2150      2160      2170      2180        

             2140      2150      2160      2170      2180      2190
pF1KE1 IAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARV
     2190      2200      2210      2220      2230      2240        

             2200      2210      2220      2230 
pF1KE1 DENRSEFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL
       :::::::::::::::::::::::::::::::::::::::::
XP_005 DENRSEFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL
     2250      2260      2270      2280         

>>XP_016866593 (OMIM: 135900,614556,614562) PREDICTED: A  (2316 aa)
 initn: 14907 init1: 11156 opt: 11536  Z-score: 4070.3  bits: 767.0 E(85289):    0
Smith-Waterman score: 15486; 98.8% identity (98.8% similar) in 2258 aa overlap (1-2231:59-2316)

                                             10        20        30
pF1KE1                               METGLLPNHKLKTVGEAPAAPPHQQHHHHH
                                     ::::::::::::::::::::::::::::::
XP_016 GSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHH
       30        40        50        60        70        80        

               40        50        60        70        80        90
pF1KE1 HAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAP
       90       100       110       120       130       140        

              100       110       120       130       140       150
pF1KE1 QPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGAL
      150       160       170       180       190       200        

              160       170       180       190       200       210
pF1KE1 GTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHS
      210       220       230       240       250       260        

              220       230       240       250       260       270
pF1KE1 ASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGG
      270       280       290       300       310       320        

              280       290       300       310       320       330
pF1KE1 AGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAA
      330       340       350       360       370       380        

              340       350       360       370       380       390
pF1KE1 SLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPP
      390       400       410       420       430       440        

              400       410       420       430       440       450
pF1KE1 PPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGP
      450       460       470       480       490       500        

              460       470       480       490       500       510
pF1KE1 TMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPG
      510       520       530       540       550       560        

              520                    530       540       550       
pF1KE1 AMAGMQYPQQQ-------------MPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQ
       :::::::::::             ::::::::::::::::::::::::::::::::::::
XP_016 AMAGMQYPQQQDSGDATWKETFWLMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQ
      570       580       590       600       610       620        

       560       570       580       590       600                 
pF1KE1 YLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLP---------
       :::::::::::::::::::::::::::::::::::::::::::::::::::         
XP_016 YLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPVEVLASEDA
      630       640       650       660       670       680        

           610       620       630       640       650       660   
pF1KE1 -----DLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGG
            :::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFGLKDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGG
      690       700       710       720       730       740        

           670       680       690       700       710       720   
pF1KE1 PSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMA
      750       760       770       780       790       800        

           730       740       750       760       770       780   
pF1KE1 GTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYS
      810       820       830       840       850       860        

           790       800       810       820       830       840   
pF1KE1 RPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMS
      870       880       890       900       910       920        

           850       860       870       880       890       900   
pF1KE1 SMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMA
      930       940       950       960       970       980        

           910       920       930       940       950       960   
pF1KE1 SSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKE
      990      1000      1010      1020      1030      1040        

           970       980       990      1000      1010      1020   
pF1KE1 EGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPKT
     1050      1060      1070      1080      1090      1100        

          1030      1040      1050      1060      1070      1080   
pF1KE1 PSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLF
     1110      1120      1130      1140      1150      1160        

          1090      1100      1110      1120      1130      1140   
pF1KE1 RLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEE
     1170      1180      1190      1200      1210      1220        

          1150      1160      1170      1180      1190      1200   
pF1KE1 PPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHG
     1230      1240      1250      1260      1270      1280        

          1210      1220      1230      1240      1250      1260   
pF1KE1 QMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDP
     1290      1300      1310      1320      1330      1340        

          1270      1280      1290      1300      1310      1320   
pF1KE1 FGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEP
     1350      1360      1370      1380      1390      1400        

          1330      1340      1350      1360      1370      1380   
pF1KE1 YGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQ
     1410      1420      1430      1440      1450      1460        

          1390      1400      1410      1420      1430      1440   
pF1KE1 EMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQ
     1470      1480      1490      1500      1510      1520        

          1450      1460      1470      1480      1490      1500   
pF1KE1 QNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQP
     1530      1540      1550      1560      1570      1580        

          1510      1520      1530      1540      1550      1560   
pF1KE1 YMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQ
     1590      1600      1610      1620      1630      1640        

          1570      1580      1590      1600      1610      1620   
pF1KE1 KVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMM
     1650      1660      1670      1680      1690      1700        

          1630      1640      1650      1660      1670      1680   
pF1KE1 SLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEY
     1710      1720      1730      1740      1750      1760        

          1690      1700      1710      1720      1730      1740   
pF1KE1 EVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKS
     1770      1780      1790      1800      1810      1820        

          1750      1760      1770      1780      1790      1800   
pF1KE1 SIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQL
     1830      1840      1850      1860      1870      1880        

          1810      1820      1830      1840      1850      1860   
pF1KE1 GGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVL
     1890      1900      1910      1920      1930      1940        

          1870      1880      1890      1900      1910      1920   
pF1KE1 SARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSL
     1950      1960      1970      1980      1990      2000        

          1930      1940      1950      1960      1970      1980   
pF1KE1 AKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDE
     2010      2020      2030      2040      2050      2060        

          1990      2000      2010      2020      2030      2040   
pF1KE1 DKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSA
     2070      2080      2090      2100      2110      2120        

          2050      2060      2070      2080      2090      2100   
pF1KE1 EAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGD
     2130      2140      2150      2160      2170      2180        

          2110      2120      2130      2140      2150      2160   
pF1KE1 RKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMH
     2190      2200      2210      2220      2230      2240        

          2170      2180      2190      2200      2210      2220   
pF1KE1 MQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICD
     2250      2260      2270      2280      2290      2300        

          2230 
pF1KE1 VLFQIGQL
       ::::::::
XP_016 VLFQIGQL
     2310      

>>XP_016866598 (OMIM: 135900,614556,614562) PREDICTED: A  (1539 aa)
 initn: 10595 init1: 10595 opt: 10595  Z-score: 3742.1  bits: 705.7 E(85289): 1.1e-201
Smith-Waterman score: 10595; 100.0% identity (100.0% similar) in 1539 aa overlap (693-2231:1-1539)

            670       680       690       700       710       720  
pF1KE1 GPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFM
                                     ::::::::::::::::::::::::::::::
XP_016                               MPPQPPGSQSESSSHPALSQSPMPQERGFM
                                             10        20        30

            730       740       750       760       770       780  
pF1KE1 AGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNY
               40        50        60        70        80        90

            790       800       810       820       830       840  
pF1KE1 SRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNM
              100       110       120       130       140       150

            850       860       870       880       890       900  
pF1KE1 SSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLM
              160       170       180       190       200       210

            910       920       930       940       950       960  
pF1KE1 ASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGK
              220       230       240       250       260       270

            970       980       990      1000      1010      1020  
pF1KE1 EEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPK
              280       290       300       310       320       330

           1030      1040      1050      1060      1070      1080  
pF1KE1 TPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDL
              340       350       360       370       380       390

           1090      1100      1110      1120      1130      1140  
pF1KE1 FRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGE
              400       410       420       430       440       450

           1150      1160      1170      1180      1190      1200  
pF1KE1 EPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPH
              460       470       480       490       500       510

           1210      1220      1230      1240      1250      1260  
pF1KE1 GQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKD
              520       530       540       550       560       570

           1270      1280      1290      1300      1310      1320  
pF1KE1 PFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHE
              580       590       600       610       620       630

           1330      1340      1350      1360      1370      1380  
pF1KE1 PYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQ
              640       650       660       670       680       690

           1390      1400      1410      1420      1430      1440  
pF1KE1 QEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGP
              700       710       720       730       740       750

           1450      1460      1470      1480      1490      1500  
pF1KE1 QQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQ
              760       770       780       790       800       810

           1510      1520      1530      1540      1550      1560  
pF1KE1 PYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKM
              820       830       840       850       860       870

           1570      1580      1590      1600      1610      1620  
pF1KE1 QKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVM
              880       890       900       910       920       930

           1630      1640      1650      1660      1670      1680  
pF1KE1 MSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILME
              940       950       960       970       980       990

           1690      1700      1710      1720      1730      1740  
pF1KE1 YEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEK
             1000      1010      1020      1030      1040      1050

           1750      1760      1770      1780      1790      1800  
pF1KE1 SSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQ
             1060      1070      1080      1090      1100      1110

           1810      1820      1830      1840      1850      1860  
pF1KE1 LGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDV
             1120      1130      1140      1150      1160      1170

           1870      1880      1890      1900      1910      1920  
pF1KE1 LSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDS
             1180      1190      1200      1210      1220      1230

           1930      1940      1950      1960      1970      1980  
pF1KE1 LAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEED
             1240      1250      1260      1270      1280      1290

           1990      2000      2010      2020      2030      2040  
pF1KE1 EDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPS
             1300      1310      1320      1330      1340      1350

           2050      2060      2070      2080      2090      2100  
pF1KE1 AEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVG
             1360      1370      1380      1390      1400      1410

           2110      2120      2130      2140      2150      2160  
pF1KE1 DRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLM
             1420      1430      1440      1450      1460      1470

           2170      2180      2190      2200      2210      2220  
pF1KE1 HMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVIC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVIC
             1480      1490      1500      1510      1520      1530

           2230 
pF1KE1 DVLFQIGQL
       :::::::::
XP_016 DVLFQIGQL
                

>>XP_016866596 (OMIM: 135900,614556,614562) PREDICTED: A  (2256 aa)
 initn: 14388 init1: 10008 opt: 10415  Z-score: 3676.7  bits: 694.1 E(85289): 4.7e-198
Smith-Waterman score: 14923; 96.1% identity (96.1% similar) in 2258 aa overlap (1-2231:59-2256)

                                             10        20        30
pF1KE1                               METGLLPNHKLKTVGEAPAAPPHQQHHHHH
                                     ::::::::::::::::::::::::::::::
XP_016 GSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHH
       30        40        50        60        70        80        

               40        50        60        70        80        90
pF1KE1 HAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAP
       90       100       110       120       130       140        

              100       110       120       130       140       150
pF1KE1 QPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGAL
      150       160       170       180       190       200        

              160       170       180       190       200       210
pF1KE1 GTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHS
      210       220       230       240       250       260        

              220       230       240       250       260       270
pF1KE1 ASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGG
      270       280       290       300       310       320        

              280       290       300       310       320       330
pF1KE1 AGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAA
      330       340       350       360       370       380        

              340       350       360       370       380       390
pF1KE1 SLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPP
      390       400       410       420       430       440        

              400       410       420       430       440       450
pF1KE1 PPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGP
      450       460       470       480       490       500        

              460       470       480       490       500       510
pF1KE1 TMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPG
      510       520       530       540       550       560        

              520                    530       540       550       
pF1KE1 AMAGMQYPQQQ-------------MPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQ
       :::::::::::             ::::::::::::::::::::::::::::::::::::
XP_016 AMAGMQYPQQQDSGDATWKETFWLMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQ
      570       580       590       600       610       620        

       560       570       580       590       600                 
pF1KE1 YLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLP---------
       :::::::::::::::::::::::::::::::::::::::::::::::::::         
XP_016 YLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPVEVLASEDA
      630       640       650       660       670       680        

           610       620       630       640       650       660   
pF1KE1 -----DLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGG
            :::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFGLKDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGG
      690       700       710       720       730       740        

           670       680       690       700       710       720   
pF1KE1 PSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMA
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::   
XP_016 PSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERG---
      750       760       770       780       790       800        

           730       740       750       760       770       780   
pF1KE1 GTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYS
                                                                :::
XP_016 ---------------------------------------------------------NYS
                                                                   

           790       800       810       820       830       840   
pF1KE1 RPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMS
      810       820       830       840       850       860        

           850       860       870       880       890       900   
pF1KE1 SMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMA
      870       880       890       900       910       920        

           910       920       930       940       950       960   
pF1KE1 SSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKE
      930       940       950       960       970       980        

           970       980       990      1000      1010      1020   
pF1KE1 EGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPKT
      990      1000      1010      1020      1030      1040        

          1030      1040      1050      1060      1070      1080   
pF1KE1 PSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLF
     1050      1060      1070      1080      1090      1100        

          1090      1100      1110      1120      1130      1140   
pF1KE1 RLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEE
     1110      1120      1130      1140      1150      1160        

          1150      1160      1170      1180      1190      1200   
pF1KE1 PPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHG
     1170      1180      1190      1200      1210      1220        

          1210      1220      1230      1240      1250      1260   
pF1KE1 QMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDP
     1230      1240      1250      1260      1270      1280        

          1270      1280      1290      1300      1310      1320   
pF1KE1 FGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEP
     1290      1300      1310      1320      1330      1340        

          1330      1340      1350      1360      1370      1380   
pF1KE1 YGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQ
     1350      1360      1370      1380      1390      1400        

          1390      1400      1410      1420      1430      1440   
pF1KE1 EMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQ
     1410      1420      1430      1440      1450      1460        

          1450      1460      1470      1480      1490      1500   
pF1KE1 QNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQP
     1470      1480      1490      1500      1510      1520        

          1510      1520      1530      1540      1550      1560   
pF1KE1 YMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQ
     1530      1540      1550      1560      1570      1580        

          1570      1580      1590      1600      1610      1620   
pF1KE1 KVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMM
     1590      1600      1610      1620      1630      1640        

          1630      1640      1650      1660      1670      1680   
pF1KE1 SLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEY
     1650      1660      1670      1680      1690      1700        

          1690      1700      1710      1720      1730      1740   
pF1KE1 EVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKS
     1710      1720      1730      1740      1750      1760        

          1750      1760      1770      1780      1790      1800   
pF1KE1 SIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQL
     1770      1780      1790      1800      1810      1820        

          1810      1820      1830      1840      1850      1860   
pF1KE1 GGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVL
     1830      1840      1850      1860      1870      1880        

          1870      1880      1890      1900      1910      1920   
pF1KE1 SARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSL
     1890      1900      1910      1920      1930      1940        

          1930      1940      1950      1960      1970      1980   
pF1KE1 AKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDE
     1950      1960      1970      1980      1990      2000        

          1990      2000      2010      2020      2030      2040   
pF1KE1 DKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSA
     2010      2020      2030      2040      2050      2060        

          2050      2060      2070      2080      2090      2100   
pF1KE1 EAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGD
     2070      2080      2090      2100      2110      2120        

          2110      2120      2130      2140      2150      2160   
pF1KE1 RKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMH
     2130      2140      2150      2160      2170      2180        

          2170      2180      2190      2200      2210      2220   
pF1KE1 MQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICD
     2190      2200      2210      2220      2230      2240        

          2230 
pF1KE1 VLFQIGQL
       ::::::::
XP_016 VLFQIGQL
     2250      

>>XP_016866592 (OMIM: 135900,614556,614562) PREDICTED: A  (2326 aa)
 initn: 13587 init1: 9207 opt: 9674  Z-score: 3416.2  bits: 646.0 E(85289): 1.5e-183
Smith-Waterman score: 15425; 98.4% identity (98.4% similar) in 2263 aa overlap (6-2231:64-2326)

                                        10        20        30     
pF1KE1                          METGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHH
                                     ::::::::::::::::::::::::::::::
XP_016 LSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHH
            40        50        60        70        80        90   

          40        50        60        70        80        90     
pF1KE1 HHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPD
           100       110       120       130       140       150   

         100       110       120       130       140       150     
pF1KE1 MEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQP
           160       170       180       190       200       210   

         160       170       180       190       200       210     
pF1KE1 PVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAA
           220       230       240       250       260       270   

         220       230       240       250       260       270     
pF1KE1 AGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGG
           280       290       300       310       320       330   

         280       290       300       310       320       330     
pF1KE1 AGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKA
           340       350       360       370       380       390   

         340       350       360       370       380       390     
pF1KE1 AAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQP
           400       410       420       430       440       450   

         400       410       420       430       440       450     
pF1KE1 QSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRS
           460       470       480       490       500       510   

         460       470       480       490       500       510     
pF1KE1 QGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGM
           520       530       540       550       560       570   

         520                    530       540       550       560  
pF1KE1 QYPQQQ-------------MPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQ
       ::::::             :::::::::::::::::::::::::::::::::::::::::
XP_016 QYPQQQDSGDATWKETFWLMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQ
           580       590       600       610       620       630   

            570       580       590       600                      
pF1KE1 SQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLP--------------
       ::::::::::::::::::::::::::::::::::::::::::::::              
XP_016 SQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPVEVLASEDAAFGLK
           640       650       660       670       680       690   

      610       620       630       640       650       660        
pF1KE1 DLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSP
           700       710       720       730       740       750   

      670       680       690       700       710       720        
pF1KE1 VGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRN
           760       770       780       790       800       810   

      730       740       750       760       770       780        
pF1KE1 PQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAY
           820       830       840       850       860       870   

      790       800       810       820       830       840        
pF1KE1 SGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPS
           880       890       900       910       920       930   

      850       860       870       880                 890        
pF1KE1 SPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSR----------QGSFPGMNQ
       :::::::::::::::::::::::::::::::::::::::::          :::::::::
XP_016 SPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRYATQEHAPGRQGSFPGMNQ
           940       950       960       970       980       990   

      900       910       920       930       940       950        
pF1KE1 SGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLK
          1000      1010      1020      1030      1040      1050   

      960       970       980       990      1000      1010        
pF1KE1 ADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSP
          1060      1070      1080      1090      1100      1110   

     1020      1030      1040      1050      1060      1070        
pF1KE1 GWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKK
          1120      1130      1140      1150      1160      1170   

     1080      1090      1100      1110      1120      1130        
pF1KE1 PLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKI
          1180      1190      1200      1210      1220      1230   

     1140      1150      1160      1170      1180      1190        
pF1KE1 ERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPA
          1240      1250      1260      1270      1280      1290   

     1200      1210      1220      1230      1240      1250        
pF1KE1 STPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYE
          1300      1310      1320      1330      1340      1350   

     1260      1270      1280      1290      1300      1310        
pF1KE1 PNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYD
          1360      1370      1380      1390      1400      1410   

     1320      1330      1340      1350      1360      1370        
pF1KE1 RRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQY
          1420      1430      1440      1450      1460      1470   

     1380      1390      1400      1410      1420      1430        
pF1KE1 SSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSS
          1480      1490      1500      1510      1520      1530   

     1440      1450      1460      1470      1480      1490        
pF1KE1 SEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHV
          1540      1550      1560      1570      1580      1590   

     1500      1510      1520      1530      1540      1550        
pF1KE1 SQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLP
          1600      1610      1620      1630      1640      1650   

     1560      1570      1580      1590      1600      1610        
pF1KE1 SMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEA
          1660      1670      1680      1690      1700      1710   

     1620      1630      1640      1650      1660      1670        
pF1KE1 WRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFG
          1720      1730      1740      1750      1760      1770   

     1680      1690      1700      1710      1720      1730        
pF1KE1 ILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTE
          1780      1790      1800      1810      1820      1830   

     1740      1750      1760      1770      1780      1790        
pF1KE1 SDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGL
          1840      1850      1860      1870      1880      1890   

     1800      1810      1820      1830      1840      1850        
pF1KE1 LHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIAT
          1900      1910      1920      1930      1940      1950   

     1860      1870      1880      1890      1900      1910        
pF1KE1 IDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAH
          1960      1970      1980      1990      2000      2010   

     1920      1930      1940      1950      1960      1970        
pF1KE1 WQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYE
          2020      2030      2040      2050      2060      2070   

     1980      1990      2000      2010      2020      2030        
pF1KE1 KEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWM
          2080      2090      2100      2110      2120      2130   

     2040      2050      2060      2070      2080      2090        
pF1KE1 VCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLV
          2140      2150      2160      2170      2180      2190   

     2100      2110      2120      2130      2140      2150        
pF1KE1 RYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQ
          2200      2210      2220      2230      2240      2250   

     2160      2170      2180      2190      2200      2210        
pF1KE1 HNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVA
          2260      2270      2280      2290      2300      2310   

     2220      2230 
pF1KE1 SVICDVLFQIGQL
       :::::::::::::
XP_016 SVICDVLFQIGQL
          2320      

>>XP_011534286 (OMIM: 135900,614556,614562) PREDICTED: A  (2359 aa)
 initn: 14893 init1: 9193 opt: 9663  Z-score: 3412.3  bits: 645.3 E(85289): 2.5e-183
Smith-Waterman score: 15092; 96.9% identity (96.9% similar) in 2263 aa overlap (39-2231:97-2359)

       10        20        30        40        50        60        
pF1KE1 HKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQ
                                     ::::::::::::::::::::::::::::::
XP_011 HKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQ
         70        80        90       100       110       120      

       70        80        90       100       110       120        
pF1KE1 QQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDED
        130       140       150       160       170       180      

      130       140       150       160       170       180        
pF1KE1 DAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGG
        190       200       210       220       230       240      

      190       200       210       220       230       240        
pF1KE1 RAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGA
        250       260       270       280       290       300      

      250       260       270       280       290       300        
pF1KE1 GGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYG
        310       320       330       340       350       360      

      310       320       330       340       350       360        
pF1KE1 VLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSP
        370       380       390       400       410       420      

      370       380       390       400       410       420        
pF1KE1 SPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAA
        430       440       450       460       470       480      

      430       440       450       460       470       480        
pF1KE1 SPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYP
        490       500       510       520       530       540      

      490       500       510       520                    530     
pF1KE1 GGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQ-------------MPPQYGQQGVSGYC
       :::::::::::::::::::::::::::::::::             ::::::::::::::
XP_011 GGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQGVSGYC
        550       560       570       580       590       600      

         540       550       560       570       580       590     
pF1KE1 QQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHED
        610       620       630       640       650       660      

         600                     610       620       630       640 
pF1KE1 LNLIQQERPSSLP--------------DLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQ
       :::::::::::::              :::::::::::::::::::::::::::::::::
XP_011 LNLIQQERPSSLPVEVLASEDAAFGLKDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQ
        670       680       690       700       710       720      

             650       660       670       680       690       700 
pF1KE1 SNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQ
        730       740       750       760       770       780      

             710       720       730       740       750       760 
pF1KE1 SESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQ
        790       800       810       820       830       840      

             770       780       790       800       810       820 
pF1KE1 QSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCG
        850       860       870       880       890       900      

             830       840       850       860       870       880 
pF1KE1 AVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQA
        910       920       930       940       950       960      

                                                        890        
pF1KE1 AANSAQSR-------------------------------------------QGSFPGMNQ
       ::::::::                                           :::::::::
XP_011 AANSAQSRPPYIRSPAYPSQSGAGGRPMFSSQHPNYGNSQAPMVHQPDQYGQGSFPGMNQ
        970       980       990      1000      1010      1020      

      900       910       920       930       940       950        
pF1KE1 SGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLK
       1030      1040      1050      1060      1070      1080      

      960       970       980       990      1000      1010        
pF1KE1 ADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSP
       1090      1100      1110      1120      1130      1140      

     1020      1030      1040      1050      1060      1070        
pF1KE1 GWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKK
       1150      1160      1170      1180      1190      1200      

     1080      1090      1100      1110      1120      1130        
pF1KE1 PLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKI
       1210      1220      1230      1240      1250      1260      

     1140      1150      1160      1170      1180      1190        
pF1KE1 ERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPA
       1270      1280      1290      1300      1310      1320      

     1200      1210      1220      1230      1240      1250        
pF1KE1 STPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYE
       1330      1340      1350      1360      1370      1380      

     1260      1270      1280      1290      1300      1310        
pF1KE1 PNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYD
       1390      1400      1410      1420      1430      1440      

     1320      1330      1340      1350      1360      1370        
pF1KE1 RRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQY
       1450      1460      1470      1480      1490      1500      

     1380      1390      1400      1410      1420      1430        
pF1KE1 SSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSS
       1510      1520      1530      1540      1550      1560      

     1440      1450      1460      1470      1480      1490        
pF1KE1 SEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHV
       1570      1580      1590      1600      1610      1620      

     1500      1510      1520      1530      1540      1550        
pF1KE1 SQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLP
       1630      1640      1650      1660      1670      1680      

     1560      1570      1580      1590      1600      1610        
pF1KE1 SMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEA
       1690      1700      1710      1720      1730      1740      

     1620      1630      1640      1650      1660      1670        
pF1KE1 WRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFG
       1750      1760      1770      1780      1790      1800      

     1680      1690      1700      1710      1720      1730        
pF1KE1 ILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTE
       1810      1820      1830      1840      1850      1860      

     1740      1750      1760      1770      1780      1790        
pF1KE1 SDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGL
       1870      1880      1890      1900      1910      1920      

     1800      1810      1820      1830      1840      1850        
pF1KE1 LHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIAT
       1930      1940      1950      1960      1970      1980      

     1860      1870      1880      1890      1900      1910        
pF1KE1 IDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAH
       1990      2000      2010      2020      2030      2040      

     1920      1930      1940      1950      1960      1970        
pF1KE1 WQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYE
       2050      2060      2070      2080      2090      2100      

     1980      1990      2000      2010      2020      2030        
pF1KE1 KEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWM
       2110      2120      2130      2140      2150      2160      

     2040      2050      2060      2070      2080      2090        
pF1KE1 VCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLV
       2170      2180      2190      2200      2210      2220      

     2100      2110      2120      2130      2140      2150        
pF1KE1 RYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQ
       2230      2240      2250      2260      2270      2280      

     2160      2170      2180      2190      2200      2210        
pF1KE1 HNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVA
       2290      2300      2310      2320      2330      2340      

     2220      2230 
pF1KE1 SVICDVLFQIGQL
       :::::::::::::
XP_011 SVICDVLFQIGQL
       2350         

>>XP_016866594 (OMIM: 135900,614556,614562) PREDICTED: A  (2306 aa)
 initn: 13964 init1: 8264 opt: 9625  Z-score: 3399.1  bits: 642.8 E(85289): 1.4e-182
Smith-Waterman score: 14902; 94.7% identity (94.7% similar) in 2301 aa overlap (1-2231:59-2306)

                                             10        20        30
pF1KE1                               METGLLPNHKLKTVGEAPAAPPHQQHHHHH
                                     ::::::::::::::::::::::::::::::
XP_016 GSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHH
       30        40        50        60        70        80        

               40        50        60        70        80        90
pF1KE1 HAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAP
       90       100       110       120       130       140        

              100       110       120       130       140       150
pF1KE1 QPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGAL
      150       160       170       180       190       200        

              160       170       180       190       200       210
pF1KE1 GTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHS
      210       220       230       240       250       260        

              220       230       240       250       260       270
pF1KE1 ASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGG
      270       280       290       300       310       320        

              280       290       300       310       320       330
pF1KE1 AGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAA
      330       340       350       360       370       380        

              340       350       360       370       380       390
pF1KE1 SLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPP
      390       400       410       420       430       440        

              400       410       420       430       440       450
pF1KE1 PPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGP
      450       460       470       480       490       500        

              460       470       480       490       500       510
pF1KE1 TMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPG
      510       520       530       540       550       560        

              520                    530       540       550       
pF1KE1 AMAGMQYPQQQ-------------MPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQ
       :::::::::::             ::::::::::::::::::::::::::::::::::::
XP_016 AMAGMQYPQQQDSGDATWKETFWLMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQ
      570       580       590       600       610       620        

       560       570       580       590       600                 
pF1KE1 YLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLP---------
       :::::::::::::::::::::::::::::::::::::::::::::::::::         
XP_016 YLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPVEVLASEDA
      630       640       650       660       670       680        

           610       620       630       640       650       660   
pF1KE1 -----DLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGG
            :::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFGLKDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGG
      690       700       710       720       730       740        

           670       680       690       700       710       720   
pF1KE1 PSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMA
      750       760       770       780       790       800        

           730       740       750       760       770       780   
pF1KE1 GTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYS
      810       820       830       840       850       860        

           790       800       810       820       830       840   
pF1KE1 RPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMS
      870       880       890       900       910       920        

           850       860       870       880                       
pF1KE1 SMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSR--------------
       ::::::::::::::::::::::::::::::::::::::::::::::              
XP_016 SMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRPPYIRSPAYPSQSG
      930       940       950       960       970       980        

                                  890       900       910       920
pF1KE1 -----------------------------QGSFPGMNQSGLMASSSPYSQPMNNSSSLMN
                                    :::::::::::::::::::::::::::::::
XP_016 AGGRPMFSSQHPNYGNSQAPMVHQPDQYGQGSFPGMNQSGLMASSSPYSQPMNNSSSLMN
      990      1000      1010      1020      1030      1040        

              930       940       950       960       970       980
pF1KE1 TQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::      
XP_016 TQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSK------
     1050      1060      1070      1080      1090      1100        

              990      1000      1010      1020      1030      1040
pF1KE1 GISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKIT
                                                      :::::::::::::
XP_016 -----------------------------------------------KSSSSTTTGEKIT
                                                          1110     

             1050      1060      1070      1080      1090      1100
pF1KE1 KVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNK
        1120      1130      1140      1150      1160      1170     

             1110      1120      1130      1140      1150      1160
pF1KE1 NKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKL
        1180      1190      1200      1210      1220      1230     

             1170      1180      1190      1200      1210      1220
pF1KE1 QPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHD
        1240      1250      1260      1270      1280      1290     

             1230      1240      1250      1260      1270      1280
pF1KE1 PFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQ
        1300      1310      1320      1330      1340      1350     

             1290      1300      1310      1320      1330      1340
pF1KE1 GQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPY
        1360      1370      1380      1390      1400      1410     

             1350      1360      1370      1380      1390      1400
pF1KE1 GGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRP
        1420      1430      1440      1450      1460      1470     

             1410      1420      1430      1440      1450      1460
pF1KE1 IQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNR
        1480      1490      1500      1510      1520      1530     

             1470      1480      1490      1500      1510      1520
pF1KE1 QGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQP
        1540      1550      1560      1570      1580      1590     

             1530      1540      1550      1560      1570      1580
pF1KE1 SYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQ
        1600      1610      1620      1630      1640      1650     

             1590      1600      1610      1620      1630      1640
pF1KE1 PPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTI
        1660      1670      1680      1690      1700      1710     

             1650      1660      1670      1680      1690      1700
pF1KE1 NILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARK
        1720      1730      1740      1750      1760      1770     

             1710      1720      1730      1740      1750      1760
pF1KE1 DDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKP
        1780      1790      1800      1810      1820      1830     

             1770      1780      1790      1800      1810      1820
pF1KE1 KQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKM
        1840      1850      1860      1870      1880      1890     

             1830      1840      1850      1860      1870      1880
pF1KE1 EIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQT
        1900      1910      1920      1930      1940      1950     

             1890      1900      1910      1920      1930      1940
pF1KE1 ESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFV
        1960      1970      1980      1990      2000      2010     

             1950      1960      1970      1980      1990      2000
pF1KE1 PGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLE
        2020      2030      2040      2050      2060      2070     

             2010      2020      2030      2040      2050      2060
pF1KE1 VLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSP
        2080      2090      2100      2110      2120      2130     

             2070      2080      2090      2100      2110      2120
pF1KE1 QRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNL
        2140      2150      2160      2170      2180      2190     

             2130      2140      2150      2160      2170      2180
pF1KE1 AQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRA
        2200      2210      2220      2230      2240      2250     

             2190      2200      2210      2220      2230 
pF1KE1 AKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL
       :::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL
        2260      2270      2280      2290      2300      

>>XP_011534290 (OMIM: 135900,614556,614562) PREDICTED: A  (1336 aa)
 initn: 9147 init1: 9147 opt: 9147  Z-score: 3234.3  bits: 611.5 E(85289): 2.1e-173
Smith-Waterman score: 9147; 100.0% identity (100.0% similar) in 1336 aa overlap (896-2231:1-1336)

         870       880       890       900       910       920     
pF1KE1 TVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPP
                                     ::::::::::::::::::::::::::::::
XP_011                               MNQSGLMASSSPYSQPMNNSSSLMNTQAPP
                                             10        20        30

         930       940       950       960       970       980     
pF1KE1 YSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQP
               40        50        60        70        80        90

         990      1000      1010      1020      1030      1040     
pF1KE1 PTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYEL
              100       110       120       130       140       150

        1050      1060      1070      1080      1090      1100     
pF1KE1 GNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWR
              160       170       180       190       200       210

        1110      1120      1130      1140      1150      1160     
pF1KE1 ELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSP
              220       230       240       250       260       270

        1170      1180      1190      1200      1210      1220     
pF1KE1 ANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDV
              280       290       300       310       320       330

        1230      1240      1250      1260      1270      1280     
pF1KE1 SDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPN
              340       350       360       370       380       390

        1290      1300      1310      1320      1330      1340     
pF1KE1 SSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQP
              400       410       420       430       440       450

        1350      1360      1370      1380      1390      1400     
pF1KE1 GLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQY
              460       470       480       490       500       510

        1410      1420      1430      1440      1450      1460     
pF1KE1 PYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGG
              520       530       540       550       560       570

        1470      1480      1490      1500      1510      1520     
pF1KE1 PTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTP
              580       590       600       610       620       630

        1530      1540      1550      1560      1570      1580     
pF1KE1 PSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIR
              640       650       660       670       680       690

        1590      1600      1610      1620      1630      1640     
pF1KE1 REITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLY
              700       710       720       730       740       750

        1650      1660      1670      1680      1690      1700     
pF1KE1 DDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQS
              760       770       780       790       800       810

        1710      1720      1730      1740      1750      1760     
pF1KE1 LADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASK
              820       830       840       850       860       870

        1770      1780      1790      1800      1810      1820     
pF1KE1 FDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPR
              880       890       900       910       920       930

        1830      1840      1850      1860      1870      1880     
pF1KE1 RRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKF
              940       950       960       970       980       990

        1890      1900      1910      1920      1930      1940     
pF1KE1 PFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDA
             1000      1010      1020      1030      1040      1050

        1950      1960      1970      1980      1990      2000     
pF1KE1 EMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDN
             1060      1070      1080      1090      1100      1110

        2010      2020      2030      2040      2050      2060     
pF1KE1 TLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVL
             1120      1130      1140      1150      1160      1170

        2070      2080      2090      2100      2110      2120     
pF1KE1 ETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDA
             1180      1190      1200      1210      1220      1230

        2130      2140      2150      2160      2170      2180     
pF1KE1 LAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALL
             1240      1250      1260      1270      1280      1290

        2190      2200      2210      2220      2230 
pF1KE1 AMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL
       ::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL
             1300      1310      1320      1330      

>>XP_016866595 (OMIM: 135900,614556,614562) PREDICTED: A  (2263 aa)
 initn: 12644 init1: 8264 opt: 8832  Z-score: 3120.6  bits: 591.3 E(85289): 4.4e-167
Smith-Waterman score: 14998; 96.5% identity (96.5% similar) in 2258 aa overlap (1-2231:59-2263)

                                             10        20        30
pF1KE1                               METGLLPNHKLKTVGEAPAAPPHQQHHHHH
                                     ::::::::::::::::::::::::::::::
XP_016 GSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHH
       30        40        50        60        70        80        

               40        50        60        70        80        90
pF1KE1 HAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAP
       90       100       110       120       130       140        

              100       110       120       130       140       150
pF1KE1 QPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGAL
      150       160       170       180       190       200        

              160       170       180       190       200       210
pF1KE1 GTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHS
      210       220       230       240       250       260        

              220       230       240       250       260       270
pF1KE1 ASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGG
      270       280       290       300       310       320        

              280       290       300       310       320       330
pF1KE1 AGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAA
      330       340       350       360       370       380        

              340       350       360       370       380       390
pF1KE1 SLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPP
      390       400       410       420       430       440        

              400       410       420       430       440       450
pF1KE1 PPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGP
      450       460       470       480       490       500        

              460       470       480       490       500       510
pF1KE1 TMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPG
      510       520       530       540       550       560        

              520                    530       540       550       
pF1KE1 AMAGMQYPQQQ-------------MPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQ
       :::::::::::             ::::::::::::::::::::::::::::::::::::
XP_016 AMAGMQYPQQQDSGDATWKETFWLMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQ
      570       580       590       600       610       620        

       560       570       580       590       600                 
pF1KE1 YLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLP---------
       :::::::::::::::::::::::::::::::::::::::::::::::::::         
XP_016 YLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPVEVLASEDA
      630       640       650       660       670       680        

           610       620       630       640       650       660   
pF1KE1 -----DLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGG
            :::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFGLKDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGG
      690       700       710       720       730       740        

           670       680       690       700       710       720   
pF1KE1 PSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMA
      750       760       770       780       790       800        

           730       740       750       760       770       780   
pF1KE1 GTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYS
      810       820       830       840       850       860        

           790       800       810       820       830       840   
pF1KE1 RPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMS
      870       880       890       900       910       920        

           850       860       870       880       890       900   
pF1KE1 SMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMA
      930       940       950       960       970       980        

           910       920       930       940       950       960   
pF1KE1 SSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKE
      990      1000      1010      1020      1030      1040        

           970       980       990      1000      1010      1020   
pF1KE1 EGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPKT
       :::::::::::                                                 
XP_016 EGTPQPESKSK-------------------------------------------------
     1050                                                          

          1030      1040      1050      1060      1070      1080   
pF1KE1 PSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLF
           ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ----KSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLF
        1060      1070      1080      1090      1100      1110     

          1090      1100      1110      1120      1130      1140   
pF1KE1 RLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEE
        1120      1130      1140      1150      1160      1170     

          1150      1160      1170      1180      1190      1200   
pF1KE1 PPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHG
        1180      1190      1200      1210      1220      1230     

          1210      1220      1230      1240      1250      1260   
pF1KE1 QMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDP
        1240      1250      1260      1270      1280      1290     

          1270      1280      1290      1300      1310      1320   
pF1KE1 FGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEP
        1300      1310      1320      1330      1340      1350     

          1330      1340      1350      1360      1370      1380   
pF1KE1 YGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQ
        1360      1370      1380      1390      1400      1410     

          1390      1400      1410      1420      1430      1440   
pF1KE1 EMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQ
        1420      1430      1440      1450      1460      1470     

          1450      1460      1470      1480      1490      1500   
pF1KE1 QNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQP
        1480      1490      1500      1510      1520      1530     

          1510      1520      1530      1540      1550      1560   
pF1KE1 YMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQ
        1540      1550      1560      1570      1580      1590     

          1570      1580      1590      1600      1610      1620   
pF1KE1 KVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMM
        1600      1610      1620      1630      1640      1650     

          1630      1640      1650      1660      1670      1680   
pF1KE1 SLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEY
        1660      1670      1680      1690      1700      1710     

          1690      1700      1710      1720      1730      1740   
pF1KE1 EVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKS
        1720      1730      1740      1750      1760      1770     

          1750      1760      1770      1780      1790      1800   
pF1KE1 SIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQL
        1780      1790      1800      1810      1820      1830     

          1810      1820      1830      1840      1850      1860   
pF1KE1 GGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVL
        1840      1850      1860      1870      1880      1890     

          1870      1880      1890      1900      1910      1920   
pF1KE1 SARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSL
        1900      1910      1920      1930      1940      1950     

          1930      1940      1950      1960      1970      1980   
pF1KE1 AKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDE
        1960      1970      1980      1990      2000      2010     

          1990      2000      2010      2020      2030      2040   
pF1KE1 DKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSA
        2020      2030      2040      2050      2060      2070     

          2050      2060      2070      2080      2090      2100   
pF1KE1 EAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGD
        2080      2090      2100      2110      2120      2130     

          2110      2120      2130      2140      2150      2160   
pF1KE1 RKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMH
        2140      2150      2160      2170      2180      2190     

          2170      2180      2190      2200      2210      2220   
pF1KE1 MQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICD
        2200      2210      2220      2230      2240      2250     

          2230 
pF1KE1 VLFQIGQL
       ::::::::
XP_016 VLFQIGQL
        2260   

>>NP_059989 (OMIM: 135900,614556,614562) AT-rich interac  (2236 aa)
 initn: 8264 init1: 8264 opt: 8763  Z-score: 3096.4  bits: 586.8 E(85289): 9.8e-166
Smith-Waterman score: 15072; 97.6% identity (97.6% similar) in 2231 aa overlap (1-2231:59-2236)

                                             10        20        30
pF1KE1                               METGLLPNHKLKTVGEAPAAPPHQQHHHHH
                                     ::::::::::::::::::::::::::::::
NP_059 GSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHH
       30        40        50        60        70        80        

               40        50        60        70        80        90
pF1KE1 HAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 HAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAP
       90       100       110       120       130       140        

              100       110       120       130       140       150
pF1KE1 QPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 QPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGAL
      150       160       170       180       190       200        

              160       170       180       190       200       210
pF1KE1 GTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 GTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHS
      210       220       230       240       250       260        

              220       230       240       250       260       270
pF1KE1 ASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 ASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGG
      270       280       290       300       310       320        

              280       290       300       310       320       330
pF1KE1 AGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 AGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAA
      330       340       350       360       370       380        

              340       350       360       370       380       390
pF1KE1 SLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 SLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPP
      390       400       410       420       430       440        

              400       410       420       430       440       450
pF1KE1 PPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 PPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGP
      450       460       470       480       490       500        

              460       470       480       490       500       510
pF1KE1 TMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 TMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPG
      510       520       530       540       550       560        

              520       530       540       550       560       570
pF1KE1 AMAGMQYPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 AMAGMQYPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQ
      570       580       590       600       610       620        

              580       590       600       610       620       630
pF1KE1 QDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 QDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVS
      630       640       650       660       670       680        

              640       650       660       670       680       690
pF1KE1 ASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 ASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPG
      690       700       710       720       730       740        

              700       710       720       730       740       750
pF1KE1 SQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 SQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPG
      750       760       770       780       790       800        

              760       770       780       790       800       810
pF1KE1 GQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 GQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQ
      810       820       830       840       850       860        

              820       830       840       850       860       870
pF1KE1 MHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 MHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRK
      870       880       890       900       910       920        

              880       890       900       910       920       930
pF1KE1 AQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 AQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAP
      930       940       950       960       970       980        

              940       950       960       970       980       990
pF1KE1 AMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGN
       ::::::::::::::::::::::::::::::::::::::::::::                
NP_059 AMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSK----------------
      990      1000      1010      1020      1030                  

             1000      1010      1020      1030      1040      1050
pF1KE1 LPVPSPMSPSSASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPE
                                            :::::::::::::::::::::::
NP_059 -------------------------------------KSSSSTTTGEKITKVYELGNEPE
                                                1040      1050     

             1060      1070      1080      1090      1100      1110
pF1KE1 RKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 RKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATN
        1060      1070      1080      1090      1100      1110     

             1120      1130      1140      1150      1160      1170
pF1KE1 LNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 LNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGS
        1120      1130      1140      1150      1160      1170     

             1180      1190      1200      1210      1220      1230
pF1KE1 LQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 LQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSF
        1180      1190      1200      1210      1220      1230     

             1240      1250      1260      1270      1280      1290
pF1KE1 PKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 PKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQD
        1240      1250      1260      1270      1280      1290     

             1300      1310      1320      1330      1340      1350
pF1KE1 MYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 MYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQ
        1300      1310      1320      1330      1340      1350     

             1360      1370      1380      1390      1400      1410
pF1KE1 QPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 QPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYS
        1360      1370      1380      1390      1400      1410     

             1420      1430      1440      1450      1460      1470
pF1KE1 RERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 RERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAP
        1420      1430      1440      1450      1460      1470     

             1480      1490      1500      1510      1520      1530
pF1KE1 PYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 PYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPN
        1480      1490      1500      1510      1520      1530     

             1540      1550      1560      1570      1580      1590
pF1KE1 HISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 HISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITF
        1540      1550      1560      1570      1580      1590     

             1600      1610      1620      1630      1640      1650
pF1KE1 PPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 PPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTV
        1600      1610      1620      1630      1640      1650     

             1660      1670      1680      1690      1700      1710
pF1KE1 ATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 ATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDS
        1660      1670      1680      1690      1700      1710     

             1720      1730      1740      1750      1760      1770
pF1KE1 GKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 GKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLP
        1720      1730      1740      1750      1760      1770     

             1780      1790      1800      1810      1820      1830
pF1KE1 IKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 IKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPP
        1780      1790      1800      1810      1820      1830     

             1840      1850      1860      1870      1880      1890
pF1KE1 PLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 PLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQ
        1840      1850      1860      1870      1880      1890     

             1900      1910      1920      1930      1940      1950
pF1KE1 QAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 QAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKH
        1900      1910      1920      1930      1940      1950     

             1960      1970      1980      1990      2000      2010
pF1KE1 PGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 PGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTL
        1960      1970      1980      1990      2000      2010     

             2020      2030      2040      2050      2060      2070
pF1KE1 ANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 ANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCK
        2020      2030      2040      2050      2060      2070     

             2080      2090      2100      2110      2120      2130
pF1KE1 LSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 LSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARA
        2080      2090      2100      2110      2120      2130     

             2140      2150      2160      2170      2180      2190
pF1KE1 IAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 IAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARV
        2140      2150      2160      2170      2180      2190     

             2200      2210      2220      2230 
pF1KE1 DENRSEFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL
       :::::::::::::::::::::::::::::::::::::::::
NP_059 DENRSEFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL
        2200      2210      2220      2230      




2231 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sun Nov  6 20:00:59 2016 done: Sun Nov  6 20:01:02 2016
 Total Scan time: 20.610 Total Display time:  1.800

Function used was FASTA [36.3.4 Apr, 2011]
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