Result of FASTA (omim) for pF1KB7302
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB7302, 1251 aa
  1>>>pF1KB7302 1251 - 1251 aa - 1251 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 12.5413+/-0.000418; mu= -8.1925+/- 0.026
 mean_var=414.6613+/-83.978, 0's: 0 Z-trim(123.9): 69  B-trim: 717 in 1/57
 Lambda= 0.062984
 statistics sampled from 44465 (44538) to 44465 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.785), E-opt: 0.2 (0.522), width:  16
 Scan time: 19.250

The best scores are:                                      opt bits E(85289)
NP_001288 (OMIM: 600724,613767) cyclic nucleotide- (1251) 8433 781.2       0
NP_001273059 (OMIM: 600724,613767) cyclic nucleoti (1245) 8370 775.5       0
XP_011521172 (OMIM: 600724,613767) PREDICTED: cycl ( 868) 5377 503.4 2.6e-141
NP_061971 (OMIM: 248200,262300,605080) cyclic nucl ( 809) 2415 234.3 2.6e-60
XP_011515440 (OMIM: 248200,262300,605080) PREDICTE ( 671) 2377 230.8 2.4e-59
NP_001129111 (OMIM: 600724,613767) cyclic nucleoti ( 299) 1998 196.1   3e-49
XP_006712306 (OMIM: 216900,600053) PREDICTED: cycl ( 731)  966 102.6   1e-20
NP_001073347 (OMIM: 216900,600053) cyclic nucleoti ( 676)  960 102.0 1.4e-20
NP_001289 (OMIM: 216900,600053) cyclic nucleotide- ( 694)  944 100.6   4e-20
XP_011508856 (OMIM: 216900,600053) PREDICTED: cycl ( 749)  944 100.6 4.2e-20
XP_011511925 (OMIM: 123825,268000,613756) PREDICTE ( 690)  922 98.6 1.6e-19
NP_000078 (OMIM: 123825,268000,613756) cGMP-gated  ( 690)  922 98.6 1.6e-19
XP_016863201 (OMIM: 123825,268000,613756) PREDICTE ( 690)  922 98.6 1.6e-19
NP_001136036 (OMIM: 123825,268000,613756) cGMP-gat ( 759)  922 98.6 1.7e-19
XP_005248106 (OMIM: 123825,268000,613756) PREDICTE ( 765)  922 98.6 1.7e-19
NP_005131 (OMIM: 300338) cyclic nucleotide-gated o ( 664)  881 94.8   2e-18
NP_001032406 (OMIM: 609472) cyclic nucleotide-gate ( 575)  836 90.7 3.1e-17
XP_016872706 (OMIM: 609472) PREDICTED: cyclic nucl ( 577)  827 89.9 5.4e-17
XP_016872707 (OMIM: 609472) PREDICTED: cyclic nucl ( 537)  799 87.3   3e-16
XP_016872708 (OMIM: 609472) PREDICTED: cyclic nucl ( 537)  799 87.3   3e-16
NP_001185 (OMIM: 602781) potassium/sodium hyperpol ( 889)  515 61.7 2.6e-08
NP_005468 (OMIM: 163800,605206,613123) potassium/s (1203)  482 58.8 2.6e-07
NP_066550 (OMIM: 602780,615871) potassium/sodium h ( 890)  467 57.3 5.4e-07
XP_011508118 (OMIM: 609973) PREDICTED: potassium/s ( 727)  453 56.0 1.1e-06
XP_011519450 (OMIM: 163800,605206,613123) PREDICTE ( 797)  454 56.1 1.1e-06
NP_065948 (OMIM: 609973) potassium/sodium hyperpol ( 774)  453 56.0 1.2e-06
XP_016857407 (OMIM: 609973) PREDICTED: potassium/s ( 535)  425 53.3 5.1e-06
XP_011508120 (OMIM: 609973) PREDICTED: potassium/s ( 535)  425 53.3 5.1e-06
XP_011508119 (OMIM: 609973) PREDICTED: potassium/s ( 720)  414 52.4 1.3e-05
NP_742054 (OMIM: 152427,609620,613688) potassium v ( 819)  344 46.1  0.0012
XP_011514487 (OMIM: 152427,609620,613688) PREDICTE (1059)  344 46.2  0.0014
XP_016867685 (OMIM: 152427,609620,613688) PREDICTE (1100)  344 46.2  0.0015
XP_016867684 (OMIM: 152427,609620,613688) PREDICTE (1109)  344 46.2  0.0015
NP_000229 (OMIM: 152427,609620,613688) potassium v (1159)  344 46.2  0.0015
XP_016874586 (OMIM: 604527) PREDICTED: potassium v ( 720)  325 44.3  0.0035
XP_016874585 (OMIM: 604527) PREDICTED: potassium v (1016)  326 44.5  0.0043
XP_011536388 (OMIM: 604527) PREDICTED: potassium v (1034)  326 44.5  0.0043
XP_011536387 (OMIM: 604527) PREDICTED: potassium v (1094)  326 44.5  0.0045
NP_001300959 (OMIM: 604527) potassium voltage-gate (1023)  325 44.4  0.0046
NP_036416 (OMIM: 604527) potassium voltage-gated c (1083)  325 44.5  0.0048


>>NP_001288 (OMIM: 600724,613767) cyclic nucleotide-gate  (1251 aa)
 initn: 8433 init1: 8433 opt: 8433  Z-score: 4156.5  bits: 781.2 E(85289):    0
Smith-Waterman score: 8433; 100.0% identity (100.0% similar) in 1251 aa overlap (1-1251:1-1251)

               10        20        30        40        50        60
pF1KB7 MLGWVQRVLPQPPGTPRKTKMQEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLGWVQRVLPQPPGTPRKTKMQEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 EEEVAVADPSPQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEEVAVADPSPQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 ITEDPAQILGHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITEDPAQILGHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVW
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 RDEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQ
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB7 AQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQV
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB7 EPDLVLEEVEPPWEDAHQDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEEEKEDEEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPDLVLEEVEPPWEDAHQDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEEEKEDEEEE
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB7 EEEEEEEEEEEVTEVLLDSCVVSQVGVGQSEEDGTRPQSTSDQKLWEEVGEEAKKEAEEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEEEEEEEEEEVTEVLLDSCVVSQVGVGQSEEDGTRPQSTSDQKLWEEVGEEAKKEAEEK
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB7 AKEEAEEVAEEEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCPLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKEEAEEVAEEEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCPLM
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB7 AEENPPSTVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESPVVAWSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEENPPSTVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESPVVAWSD
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB7 PTTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKP
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB7 SPAKKAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDPLTNLMYVLWL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPAKKAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDPLTNLMYVLWL
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB7 FFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGD
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB7 IITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEFNSRLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEFNSRLE
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB7 SILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVGNSYIRCYYFAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVGNSYIRCYYFAV
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB7 KTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDST
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB7 VKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKV
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB7 ALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLV
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB7 TLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKA
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB7 RRMLRSNNKPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRMLRSNNKPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELA
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KB7 ALEAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALEAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSP
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250 
pF1KB7 PPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKAE
       :::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKAE
             1210      1220      1230      1240      1250 

>>NP_001273059 (OMIM: 600724,613767) cyclic nucleotide-g  (1245 aa)
 initn: 7132 init1: 7132 opt: 8370  Z-score: 4125.5  bits: 775.5 E(85289):    0
Smith-Waterman score: 8370; 99.5% identity (99.5% similar) in 1251 aa overlap (1-1251:1-1245)

               10        20        30        40        50        60
pF1KB7 MLGWVQRVLPQPPGTPRKTKMQEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLGWVQRVLPQPPGTPRKTKMQEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 EEEVAVADPSPQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEEVAVADPSPQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 ITEDPAQILGHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITEDPAQILGHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVW
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 RDEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQ
       ::::::::      ::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDEPAVAT------APPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQ
                    190       200       210       220       230    

              250       260       270       280       290       300
pF1KB7 AQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQV
          240       250       260       270       280       290    

              310       320       330       340       350       360
pF1KB7 EPDLVLEEVEPPWEDAHQDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEEEKEDEEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPDLVLEEVEPPWEDAHQDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEEEKEDEEEE
          300       310       320       330       340       350    

              370       380       390       400       410       420
pF1KB7 EEEEEEEEEEEVTEVLLDSCVVSQVGVGQSEEDGTRPQSTSDQKLWEEVGEEAKKEAEEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEEEEEEEEEEVTEVLLDSCVVSQVGVGQSEEDGTRPQSTSDQKLWEEVGEEAKKEAEEK
          360       370       380       390       400       410    

              430       440       450       460       470       480
pF1KB7 AKEEAEEVAEEEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCPLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKEEAEEVAEEEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCPLM
          420       430       440       450       460       470    

              490       500       510       520       530       540
pF1KB7 AEENPPSTVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESPVVAWSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEENPPSTVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESPVVAWSD
          480       490       500       510       520       530    

              550       560       570       580       590       600
pF1KB7 PTTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKP
          540       550       560       570       580       590    

              610       620       630       640       650       660
pF1KB7 SPAKKAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDPLTNLMYVLWL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPAKKAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDPLTNLMYVLWL
          600       610       620       630       640       650    

              670       680       690       700       710       720
pF1KB7 FFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGD
          660       670       680       690       700       710    

              730       740       750       760       770       780
pF1KB7 IITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEFNSRLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEFNSRLE
          720       730       740       750       760       770    

              790       800       810       820       830       840
pF1KB7 SILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVGNSYIRCYYFAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVGNSYIRCYYFAV
          780       790       800       810       820       830    

              850       860       870       880       890       900
pF1KB7 KTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDST
          840       850       860       870       880       890    

              910       920       930       940       950       960
pF1KB7 VKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKV
          900       910       920       930       940       950    

              970       980       990      1000      1010      1020
pF1KB7 ALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLV
          960       970       980       990      1000      1010    

             1030      1040      1050      1060      1070      1080
pF1KB7 TLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKA
         1020      1030      1040      1050      1060      1070    

             1090      1100      1110      1120      1130      1140
pF1KB7 RRMLRSNNKPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRMLRSNNKPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELA
         1080      1090      1100      1110      1120      1130    

             1150      1160      1170      1180      1190      1200
pF1KB7 ALEAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALEAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSP
         1140      1150      1160      1170      1180      1190    

             1210      1220      1230      1240      1250 
pF1KB7 PPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKAE
       :::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKAE
         1200      1210      1220      1230      1240     

>>XP_011521172 (OMIM: 600724,613767) PREDICTED: cyclic n  (868 aa)
 initn: 5377 init1: 5377 opt: 5377  Z-score: 2658.0  bits: 503.4 E(85289): 2.6e-141
Smith-Waterman score: 5377; 100.0% identity (100.0% similar) in 794 aa overlap (458-1251:75-868)

       430       440       450       460       470       480       
pF1KB7 VAEEEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCPLMAEENPPS
                                     ::::::::::::::::::::::::::::::
XP_011 ITRIPVLTSRRTSLSNSSFAKETRSSIRQLVPATKQHPEVQVEDTDADSCPLMAEENPPS
           50        60        70        80        90       100    

       490       500       510       520       530       540       
pF1KB7 TVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESPVVAWSDPTTPKDT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESPVVAWSDPTTPKDT
          110       120       130       140       150       160    

       550       560       570       580       590       600       
pF1KB7 DGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKPSPAKKAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKPSPAKKAP
          170       180       190       200       210       220    

       610       620       630       640       650       660       
pF1KB7 EPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDPLTNLMYVLWLFFVVMAW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDPLTNLMYVLWLFFVVMAW
          230       240       250       260       270       280    

       670       680       690       700       710       720       
pF1KB7 NWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGDIITDKKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGDIITDKKD
          290       300       310       320       330       340    

       730       740       750       760       770       780       
pF1KB7 MRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEFNSRLESILSKAY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEFNSRLESILSKAY
          350       360       370       380       390       400    

       790       800       810       820       830       840       
pF1KB7 VYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVGNSYIRCYYFAVKTLITIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVGNSYIRCYYFAVKTLITIG
          410       420       430       440       450       460    

       850       860       870       880       890       900       
pF1KB7 GLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFY
          470       480       490       500       510       520    

       910       920       930       940       950       960       
pF1KB7 KIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCD
          530       540       550       560       570       580    

       970       980       990      1000      1010      1020       
pF1KB7 RQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSV
          590       600       610       620       630       640    

      1030      1040      1050      1060      1070      1080       
pF1KB7 FGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRMLRSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRMLRSN
          650       660       670       680       690       700    

      1090      1100      1110      1120      1130      1140       
pF1KB7 NKPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELAALEAAAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELAALEAAAK
          710       720       730       740       750       760    

      1150      1160      1170      1180      1190      1200       
pF1KB7 QQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSPPPASLGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSPPPASLGR
          770       780       790       800       810       820    

      1210      1220      1230      1240      1250 
pF1KB7 PEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKAE
       ::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKAE
          830       840       850       860        

>>NP_061971 (OMIM: 248200,262300,605080) cyclic nucleoti  (809 aa)
 initn: 2219 init1: 2136 opt: 2415  Z-score: 1203.8  bits: 234.3 E(85289): 2.6e-60
Smith-Waterman score: 2428; 46.2% identity (72.2% similar) in 853 aa overlap (409-1248:14-809)

      380       390       400       410       420       430        
pF1KB7 SCVVSQVGVGQSEEDGTRPQSTSDQKLWEEVGEEAKKEAEEKAKEEAEEVAEEEAEKEPQ
                                     .::. ..:   . .::. . ...  .   :
NP_061                  MFKSLTKVNKVKPIGENNENEQSSRRNEEGSHPSNQSQQTTAQ
                                10        20        30        40   

      440       450       460       470       480       490        
pF1KB7 DWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCPLMAEENPPSTVLPPPSPAKS
       .  :.: :   :    ....:.:...:.....:        ....:  . .   :.: ..
NP_061 E--ENKGE---EKSLKTKSTPVTSEEPHTNIQDK-------LSKKNSSGDLTTNPDPQNA
                 50        60        70               80        90 

      500       510       520       530       540       550        
pF1KB7 DTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESPVVAWSDPTTPKDTDGQDRAASTAS
             .  .::    .:       : : ..:..        :..:     :..  ..  
NP_061 ------AEPTGT----VP-------EQKEMDPGKE------GPNSP-----QNKPPAAPV
                              100             110            120   

      560       570       580       590       600       610        
pF1KB7 TNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKPSPAKKAPEPAPDTKPAEA
        :    . .:..::: ...::   :.::.. :..:    :. ::    :  .: .: .. 
NP_061 INE-YADAQLHNLVKRMRQRTALYKKKLVEGDLSS----PEASPQTAKPTAVPPVKESDD
            130       140       150           160       170        

      620       630       640           650       660       670    
pF1KB7 EPVEEEHYCDMLCCKFKHRPWKKY----QFPQSIDPLTNLMYVLWLFFVVMAWNWNCWLI
       .:.:  ::  .:  : :. :  .:    ..:.:::  :. .:.:::..:..:.:::: .:
NP_061 KPTE--HYYRLLWFKVKKMPLTEYLKRIKLPNSIDSYTDRLYLLWLLLVTLAYNWNCCFI
      180         190       200       210       220       230      

          680       690       700       710       720       730    
pF1KB7 PVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGDIITDKKDMRNNYLK
       :.: .::::: ::::.::. : .::.::. :.  .: :::::::::::.:....:..:  
NP_061 PLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRGGDIIVDSNELRKHYRT
        240       250       260       270       280       290      

          740       750       760       770       780       790    
pF1KB7 SRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEFNSRLESILSKAYVYRVIRT
       : .:..:. :..:.:. ::  : ::..:  : ::: .::::: .::::..:::.::::::
NP_061 STKFQLDVASIIPFDICYLFFGFNPMFRANRMLKYTSFFEFNHHLESIMDKAYIYRVIRT
        300       310       320       330       340       350      

          800       810       820       830       840       850    
pF1KB7 TAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVGNSYIRCYYFAVKTLITIGGLPDPKT
       :.:::. ::.:.:.::::: :.:.:.:.::::: :: :.::::.::.:::::::::.:.:
NP_061 TGYLLFILHINACVYYWASNYEGIGTTRWVYDGEGNEYLRCYYWAVRTLITIGGLPEPQT
        360       370       380       390       400       410      

          860       870       880       890       900       910    
pF1KB7 LFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQ
       ::::::::::.:.:::.:: .:::::::.:::::.:.:.:.:::.:. ::: :.::: ::
NP_061 LFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQ
        420       430       440       450       460       470      

          920       930       940       950       960       970    
pF1KB7 NRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDM
       .::.::::::: :: :::::.:.  ::  ..: ::::::..:.::: ::.::: :::.::
NP_061 KRVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDM
        480       490       500       510       520       530      

          980       990      1000      1010      1020      1030    
pF1KB7 LKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLL
       : ::.::.:::.:.::::::::.:::::. :.::::::::: .:::::::::::::::::
NP_061 LLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGEISLL
        540       550       560       570       580       590      

         1040      1050      1060      1070      1080              
pF1KB7 AVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRMLRSNNK-----
       :.:::::::::::::::.::. :::: :.:::::::.:...: :::: .:... :     
NP_061 AAGGGNRRTANVVAHGFANLLTLDKKTLQEILVHYPDSERILMKKARVLLKQKAKTAEAT
        600       610       620       630       640       650      

    1090      1100      1110      1120      1130      1140         
pF1KB7 PKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELAALEAAAKQQ
       : ..  .:..::.  :::::.. :. :::        ..::.:  .::.  : .   ...
NP_061 PPRKDLALLFPPKEETPKLFKTLLGGTGK--------ASLARL-LKLKREQAAQKKENSE
        660       670       680               690        700       

    1150      1160      1170      1180      1190        1200       
pF1KB7 ELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPP--SSPPPASLGR
          :..: ..: . :. .   ... . ::   :    : : : : . :  .. : :   .
NP_061 GGEEEGKENEDKQKENEDKQKENEDKGKENE-DKDKGREPEEKPLDRPECTASPIAVEEE
       710       720       730        740       750       760      

      1210        1220      1230      1240      1250 
pF1KB7 PEGEEEG--PAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKAE
       :.. ..   :    ..:. : :.:. : ::..:.... :. ..   
NP_061 PHSVRRTVLPRGTSRQSLIISMAPSAEGGEEVLTIEVKEKAKQ   
        770       780       790       800            

>>XP_011515440 (OMIM: 248200,262300,605080) PREDICTED: c  (671 aa)
 initn: 2136 init1: 2136 opt: 2377  Z-score: 1186.3  bits: 230.8 E(85289): 2.4e-59
Smith-Waterman score: 2377; 52.9% identity (77.4% similar) in 686 aa overlap (576-1248:2-671)

         550       560       570       580       590       600     
pF1KB7 DTDGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKPSPAKK
                                     ..::   :.::.. :..    ::. ::   
XP_011                              MRQRTALYKKKLVEGDLS----SPEASPQTA
                                            10            20       

         610       620       630       640           650       660 
pF1KB7 APEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKY----QFPQSIDPLTNLMYVLWLF
        :  .: .: .. .:.:  ::  .:  : :. :  .:    ..:.:::  :. .:.:::.
XP_011 KPTAVPPVKESDDKPTE--HYYRLLWFKVKKMPLTEYLKRIKLPNSIDSYTDRLYLLWLL
        30        40          50        60        70        80     

             670       680       690       700       710       720 
pF1KB7 FVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGDI
       .:..:.:::: .::.: .::::: ::::.::. : .::.::. :.  .: ::::::::::
XP_011 LVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRGGDI
          90       100       110       120       130       140     

             730       740       750       760       770       780 
pF1KB7 ITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEFNSRLES
       :.:....:..:  : .:..:. :..:.:. ::  : ::..:  : ::: .::::: .:::
XP_011 IVDSNELRKHYRTSTKFQLDVASIIPFDICYLFFGFNPMFRANRMLKYTSFFEFNHHLES
         150       160       170       180       190       200     

             790       800       810       820       830       840 
pF1KB7 ILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVGNSYIRCYYFAVK
       :..:::.:::::::.:::. ::.:.:.::::: :.:.:.:.::::: :: :.::::.::.
XP_011 IMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTRWVYDGEGNEYLRCYYWAVR
         210       220       230       240       250       260     

             850       860       870       880       890       900 
pF1KB7 TLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTV
       :::::::::.:.:::::::::::.:.:::.:: .:::::::.:::::.:.:.:.:::.:.
XP_011 TLITIGGLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTI
         270       280       290       300       310       320     

             910       920       930       940       950       960 
pF1KB7 KYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVA
        ::: :.::: ::.::.::::::: :: :::::.:.  ::  ..: ::::::..:.::: 
XP_011 AYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVD
         330       340       350       360       370       380     

             970       980       990      1000      1010      1020 
pF1KB7 LFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVT
       ::.::: :::.::: ::.::.:::.:.::::::::.:::::. :.::::::::: .::::
XP_011 LFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVT
         390       400       410       420       430       440     

            1030      1040      1050      1060      1070      1080 
pF1KB7 LKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKAR
       ::::::::::::::.:::::::::::::::.::. :::: :.:::::::.:...: ::::
XP_011 LKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILVHYPDSERILMKKAR
         450       460       470       480       490       500     

                 1090      1100      1110      1120      1130      
pF1KB7 RMLRSNNK-----PKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARL
        .:... :     : ..  .:..::.  :::::.. :. :::        ..::.:  .:
XP_011 VLLKQKAKTAEATPPRKDLALLFPPKEETPKLFKTLLGGTGK--------ASLARL-LKL
         510       520       530       540               550       

       1140      1150      1160      1170      1180      1190      
pF1KB7 KELAALEAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSP
       :.  : .   ...   :..: ..: . :. .   ... . ::   :    : : : : . 
XP_011 KREQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENE-DKDKGREPEEKPLDR
        560       570       580       590       600        610     

         1200      1210        1220      1230      1240      1250 
pF1KB7 P--SSPPPASLGRPEGEEEG--PAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKAE
       :  .. : :   .:.. ..   :    ..:. : :.:. : ::..:.... :. ..   
XP_011 PECTASPIAVEEEPHSVRRTVLPRGTSRQSLIISMAPSAEGGEEVLTIEVKEKAKQ   
         620       630       640       650       660       670    

>>NP_001129111 (OMIM: 600724,613767) cyclic nucleotide-g  (299 aa)
 initn: 1998 init1: 1998 opt: 1998  Z-score: 1005.2  bits: 196.1 E(85289): 3e-49
Smith-Waterman score: 1998; 98.3% identity (98.7% similar) in 298 aa overlap (1-298:1-298)

               10        20        30        40        50        60
pF1KB7 MLGWVQRVLPQPPGTPRKTKMQEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLGWVQRVLPQPPGTPRKTKMQEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 EEEVAVADPSPQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEEVAVADPSPQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 ITEDPAQILGHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITEDPAQILGHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVW
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 RDEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQ
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB7 AQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQV
       :::::::::::::::::::::::::::::::::::::::::::::::::::  .  ::  
NP_001 AQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTRVMGAGGL 
              250       260       270       280       290          

              310       320       330       340       350       360
pF1KB7 EPDLVLEEVEPPWEDAHQDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEEEKEDEEEE

>>XP_006712306 (OMIM: 216900,600053) PREDICTED: cyclic n  (731 aa)
 initn: 971 init1: 482 opt: 966  Z-score: 492.9  bits: 102.6 E(85289): 1e-20
Smith-Waterman score: 1116; 29.2% identity (60.3% similar) in 736 aa overlap (461-1171:12-722)

              440       450       460       470            480     
pF1KB7 EEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCP-----LMAEENP
                                     .. : .:.. : : .          .  . 
XP_006                    MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEE
                                  10        20        30        40 

         490       500           510       520       530       540 
pF1KB7 PSTVLPPPSPAKSDTLIVPSSAS----GTHRKKLPSEDDEAEELKALSPAESPVVAWSDP
        :.:: :    ..  :   ...:    :  :    .. .. :..   .    :...:.. 
XP_006 TSSVLQPGIAMETRGLADSGQGSFTGQGIARFGRIQKKSQPEKVVRAASRGRPLIGWTQW
              50        60        70        80        90       100 

             550       560       570       580        590       600
pF1KB7 TTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERTEK-VKEKLIDPDVTSDEESPKP
        .    : .. : . .   :.  . ::..:. :... . . :...   ::   :.     
XP_006 CAEDGGDESEMALAGSPGCSSGPQGRLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAE
             110       120       130       140       150       160 

              610       620       630       640       650       660
pF1KB7 SPAKKAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDPLTNLMYVLWL
           .. :   ... .  ::...            .:   : .    .:: .::.:  ::
XP_006 LKEVSSQESNAQANVGSQEPADR-----------GRRKKTKKKDAIVVDPSSNLYYR-WL
             170       180                  190       200          

              670       680       690       700       710       720
pF1KB7 FFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGD
         ...   .: .:.  :  :     . .  ::..::  :..: ::. : ..:  :.. : 
XP_006 TAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLV-RARTGFLEQGL
     210       220       230       240       250        260        

              730       740       750        760       770         
pF1KB7 IITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVN-PLLRLPRCLKYMAFFEFNSRL
       ...: . . ..:  . .::.:.:::.: :. :::::.: : .:. : ::.  .::: .: 
XP_006 MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRT
      270       280       290       300       310       320        

     780       790       800       810       820               830 
pF1KB7 ESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVG--------NS
       :.  .   ..:.   . :.:  .: :.:.:.  : . :.:.  ::: ...         .
XP_006 ETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRK
      330       340       350       360       370       380        

             840       850       860       870       880       890 
pF1KB7 YIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQT
       ::   :... :: :::  : :    : .: ......::. :....:.. ....  .:...
XP_006 YIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRA
      390       400       410       420       430       440        

             900       910       920       930       940       950 
pF1KB7 YYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAID
        ... .::  .::.: :. :....::  :..: : ..  .::.:.. .::::.. ..::.
XP_006 EFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAIN
      450       460       470       480       490       500        

             960       970       980       990      1000      1010 
pF1KB7 VNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLG
       :. . ..:: .:: :.  .. ... .:: .:. :.::.::::.::.:::::. :.. :..
XP_006 VHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVA
      510       520       530       540       550       560        

            1020      1030         1040      1050      1060        
pF1KB7 GPDGKSVLVTLKAGSVFGEISLLAVGG---GNRRTANVVAHGFTNLFILDKKDLNEILVH
         :: . .:.:. :: :::::.: . :   :::::::. . :...:: :.: :: : :..
XP_006 D-DGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTE
       570       580       590       600       610       620       

     1070      1080      1090      1100       1110      1120       
pF1KB7 YPESQKLLRKKARRMLRSNNKPKEEKSVLILPPRAGT-PKLFNAALAMTGKMGGKGAKGG
       :::..: :..:.:..: ..:   :: .      :::. :: ..  . . :.  .  .   
XP_006 YPEAKKALEEKGRQILMKDNLIDEELA------RAGADPKDLEEKVEQLGS--SLDTLQT
       630       640       650             660       670           

      1130      1140        1150      1160      1170      1180     
pF1KB7 KLAHLRARLKELAALEAAAKQQ--ELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPA
       ..:.:   : :  : .   ::.  .:  :.:.. :    .: .  :              
XP_006 RFARL---LAEYNATQMKMKQRLSQLESQVKGGGDKPLADGEVPGDATKTEDKQQ     
     680          690       700       710       720       730      

        1190      1200      1210      1220      1230      1240     
pF1KB7 PRTPPEPPGSPPSSPPPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEE

>>NP_001073347 (OMIM: 216900,600053) cyclic nucleotide-g  (676 aa)
 initn: 971 init1: 482 opt: 960  Z-score: 490.4  bits: 102.0 E(85289): 1.4e-20
Smith-Waterman score: 1110; 31.2% identity (62.2% similar) in 686 aa overlap (505-1171:9-667)

          480       490       500       510       520       530    
pF1KB7 DSCPLMAEENPPSTVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESP
                                     :  : :: :   :. :  .  ..:: :.: 
NP_001                       MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSS
                                     10        20        30        

          540          550       560       570       580        590
pF1KB7 VVAWSD---PTTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERTEK-VKEKLIDPD
           :.   :    .: :   ... . :...:   ::..:. :... . . :...   ::
NP_001 SEETSSVLQPGIAMETRGLADSGQGSFTGQGIA--RLSRLIFLLRRWAARHVHHQDQGPD
       40        50        60        70          80        90      

              600       610       620       630       640       650
pF1KB7 VTSDEESPKPSPAKKAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDP
          :.         .. :   ... .  ::... .         ...  ::  .   .::
NP_001 SFPDRFRGAELKEVSSQESNAQANVGSQEPADRGR---------RKKTKKKDAI--VVDP
        100       110       120       130                140       

              660       670       680       690       700       710
pF1KB7 LTNLMYVLWLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQ
        .::.:  ::  ...   .: .:.  :  :     . .  ::..::  :..: ::. : .
NP_001 SSNLYYR-WLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLV-R
         150        160       170       180       190       200    

              720       730       740       750        760         
pF1KB7 TRLQFVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVN-PLLRLPRCLKY
       .:  :.. : ...: . . ..:  . .::.:.:::.: :. :::::.: : .:. : ::.
NP_001 ARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKF
           210       220       230       240       250       260   

     770       780       790       800       810       820         
pF1KB7 MAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVG
         .::: .: :.  .   ..:.   . :.:  .: :.:.:.  : . :.:.  ::: ...
NP_001 SRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNIS
           270       280       290       300       310       320   

             830       840       850       860       870       880 
pF1KB7 --------NSYIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRD
                .::   :... :: :::  : :    : .: ......::. :....:.. .
NP_001 IPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGS
           330       340       350       360       370       380   

             890       900       910       920       930       940 
pF1KB7 VVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLP
       ...  .:... ... .::  .::.: :. :....::  :..: : ..  .::.:.. .::
NP_001 MISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLP
           390       400       410       420       430       440   

             950       960       970       980       990      1000 
pF1KB7 DKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYI
       ::.. ..::.:. . ..:: .:: :.  .. ... .:: .:. :.::.::::.::.::::
NP_001 DKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYI
           450       460       470       480       490       500   

            1010      1020      1030         1040      1050        
pF1KB7 IQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGG---GNRRTANVVAHGFTNLFILD
       :. :.. :..  :: . .:.:. :: :::::.: . :   :::::::. . :...:: :.
NP_001 INEGKLAVVAD-DGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLS
           510        520       530       540       550       560  

     1060      1070      1080      1090      1100       1110       
pF1KB7 KKDLNEILVHYPESQKLLRKKARRMLRSNNKPKEEKSVLILPPRAGT-PKLFNAALAMTG
       : :: : :..:::..: :..:.:..: ..:   :: .      :::. :: ..  . . :
NP_001 KDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELA------RAGADPKDLEEKVEQLG
            570       580       590             600       610      

      1120      1130      1140        1150      1160      1170     
pF1KB7 KMGGKGAKGGKLAHLRARLKELAALEAAAKQQ--ELVEQAKSSQDVKGEEGSAAPDQHTH
       .  .  .   ..:.:   : :  : .   ::.  .:  :.:.. :    .: .  :    
NP_001 S--SLDTLQTRFARL---LAEYNATQMKMKQRLSQLESQVKGGGDKPLADGEVPGDATKT
          620          630       640       650       660       670 

        1180      1190      1200      1210      1220      1230     
pF1KB7 PKEAATDPPAPRTPPEPPGSPPSSPPPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGE
                                                                   
NP_001 EDKQQ                                                       
                                                                   

>>NP_001289 (OMIM: 216900,600053) cyclic nucleotide-gate  (694 aa)
 initn: 971 init1: 482 opt: 944  Z-score: 482.4  bits: 100.6 E(85289): 4e-20
Smith-Waterman score: 1114; 31.4% identity (61.7% similar) in 695 aa overlap (505-1171:9-685)

          480       490       500       510       520       530    
pF1KB7 DSCPLMAEENPPSTVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESP
                                     :  : :: :   :. :  .  ..:: :.: 
NP_001                       MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSS
                                     10        20        30        

          540          550       560       570       580        590
pF1KB7 VVAWSD---PTTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERTEK-VKEKLIDPD
           :.   :    .: :   ... . :...:   ::..:. :... . . :...   ::
NP_001 SEETSSVLQPGIAMETRGLADSGQGSFTGQGIA--RLSRLIFLLRRWAARHVHHQDQGPD
       40        50        60        70          80        90      

                      600        610       620       630       640 
pF1KB7 VTSD--------EESPKPSPAK-KAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKK
          :        : : . : :. ..    :  .   : :. . .       . ...  ::
NP_001 SFPDRFRGAELKEVSSQESNAQANVGSQEPADRGRSAWPLAKCNTNTSNNTEEEKKTKKK
        100       110       120       130       140       150      

             650       660       670       680       690       700 
pF1KB7 YQFPQSIDPLTNLMYVLWLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLI
         .   .:: .::.:  ::  ...   .: .:.  :  :     . .  ::..::  :..
NP_001 DAI--VVDPSSNLYYR-WLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVL
          160       170        180       190       200       210   

             710       720       730       740       750        760
pF1KB7 YFLDITVFQTRLQFVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVN-PL
       : ::. : ..:  :.. : ...: . . ..:  . .::.:.:::.: :. :::::.: : 
NP_001 YVLDVLV-RARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPE
           220        230       240       250       260       270  

              770       780       790       800       810       820
pF1KB7 LRLPRCLKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGS
       .:. : ::.  .::: .: :.  .   ..:.   . :.:  .: :.:.:.  : . :.:.
NP_001 VRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGT
            280       290       300       310       320       330  

                      830       840       850       860       870  
pF1KB7 THWVYDGVG--------NSYIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFTGVFAF
         ::: ...         .::   :... :: :::  : :    : .: ......::. :
NP_001 DSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIF
            340       350       360       370       380       390  

            880       890       900       910       920       930  
pF1KB7 SVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLD
       ....:.. ....  .:... ... .::  .::.: :. :....::  :..: : ..  .:
NP_001 ATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVD
            400       410       420       430       440       450  

            940       950       960       970       980       990  
pF1KB7 ESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKK
       :.:.. .::::.. ..::.:. . ..:: .:: :.  .. ... .:: .:. :.::.:::
NP_001 EKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKK
            460       470       480       490       500       510  

           1000      1010      1020      1030         1040         
pF1KB7 GEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGG---GNRRTANVVAH
       :.::.:::::. :.. :..  :: . .:.:. :: :::::.: . :   :::::::. . 
NP_001 GDIGKEMYIINEGKLAVVAD-DGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSI
            520       530        540       550       560       570 

    1050      1060      1070      1080      1090      1100         
pF1KB7 GFTNLFILDKKDLNEILVHYPESQKLLRKKARRMLRSNNKPKEEKSVLILPPRAGT-PKL
       :...:: :.: :: : :..:::..: :..:.:..: ..:   :: .      :::. :: 
NP_001 GYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELA------RAGADPKD
             580       590       600       610             620     

     1110      1120      1130      1140        1150      1160      
pF1KB7 FNAALAMTGKMGGKGAKGGKLAHLRARLKELAALEAAAKQQ--ELVEQAKSSQDVKGEEG
       ..  . . :.  .  .   ..:.:   : :  : .   ::.  .:  :.:.. :    .:
NP_001 LEEKVEQLGS--SLDTLQTRFARL---LAEYNATQMKMKQRLSQLESQVKGGGDKPLADG
         630         640          650       660       670       680

       1170      1180      1190      1200      1210      1220      
pF1KB7 SAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSPPPASLGRPEGEEEGPAEPEEHSVRIC
        .  :                                                       
NP_001 EVPGDATKTEDKQQ                                              
              690                                                  

>>XP_011508856 (OMIM: 216900,600053) PREDICTED: cyclic n  (749 aa)
 initn: 971 init1: 482 opt: 944  Z-score: 481.9  bits: 100.6 E(85289): 4.2e-20
Smith-Waterman score: 1120; 29.4% identity (60.3% similar) in 745 aa overlap (461-1171:12-740)

              440       450       460       470            480     
pF1KB7 EEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCP-----LMAEENP
                                     .. : .:.. : : .          .  . 
XP_011                    MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEE
                                  10        20        30        40 

         490       500           510       520       530       540 
pF1KB7 PSTVLPPPSPAKSDTLIVPSSAS----GTHRKKLPSEDDEAEELKALSPAESPVVAWSDP
        :.:: :    ..  :   ...:    :  :    .. .. :..   .    :...:.. 
XP_011 TSSVLQPGIAMETRGLADSGQGSFTGQGIARFGRIQKKSQPEKVVRAASRGRPLIGWTQW
              50        60        70        80        90       100 

             550       560       570       580        590          
pF1KB7 TTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERTEK-VKEKLIDPDVTSD------
        .    : .. : . .   :.  . ::..:. :... . . :...   ::   :      
XP_011 CAEDGGDESEMALAGSPGCSSGPQGRLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAE
             110       120       130       140       150       160 

            600        610       620       630       640       650 
pF1KB7 --EESPKPSPAK-KAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDPL
         : : . : :. ..    :  .   : :. . .       . ...  ::  .   .:: 
XP_011 LKEVSSQESNAQANVGSQEPADRGRSAWPLAKCNTNTSNNTEEEKKTKKKDAI--VVDPS
             170       180       190       200       210           

             660       670       680       690       700       710 
pF1KB7 TNLMYVLWLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQT
       .::.:  ::  ...   .: .:.  :  :     . .  ::..::  :..: ::. : ..
XP_011 SNLYYR-WLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLV-RA
     220        230       240       250       260       270        

             720       730       740       750        760       770
pF1KB7 RLQFVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVN-PLLRLPRCLKYM
       :  :.. : ...: . . ..:  . .::.:.:::.: :. :::::.: : .:. : ::. 
XP_011 RTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFS
       280       290       300       310       320       330       

              780       790       800       810       820          
pF1KB7 AFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVG-
        .::: .: :.  .   ..:.   . :.:  .: :.:.:.  : . :.:.  ::: ... 
XP_011 RLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISI
       340       350       360       370       380       390       

            830       840       850       860       870       880  
pF1KB7 -------NSYIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDV
               .::   :... :: :::  : :    : .: ......::. :....:.. ..
XP_011 PEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSM
       400       410       420       430       440       450       

            890       900       910       920       930       940  
pF1KB7 VGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPD
       ..  .:... ... .::  .::.: :. :....::  :..: : ..  .::.:.. .:::
XP_011 ISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPD
       460       470       480       490       500       510       

            950       960       970       980       990      1000  
pF1KB7 KMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYII
       :.. ..::.:. . ..:: .:: :.  .. ... .:: .:. :.::.::::.::.:::::
XP_011 KLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYII
       520       530       540       550       560       570       

           1010      1020      1030         1040      1050         
pF1KB7 QAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGG---GNRRTANVVAHGFTNLFILDK
       . :.. :..  :: . .:.:. :: :::::.: . :   :::::::. . :...:: :.:
XP_011 NEGKLAVVAD-DGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSK
       580        590       600       610       620       630      

    1060      1070      1080      1090      1100       1110        
pF1KB7 KDLNEILVHYPESQKLLRKKARRMLRSNNKPKEEKSVLILPPRAGT-PKLFNAALAMTGK
        :: : :..:::..: :..:.:..: ..:   :: .      :::. :: ..  . . :.
XP_011 DDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELA------RAGADPKDLEEKVEQLGS
        640       650       660       670             680       690

     1120      1130      1140        1150      1160      1170      
pF1KB7 MGGKGAKGGKLAHLRARLKELAALEAAAKQQ--ELVEQAKSSQDVKGEEGSAAPDQHTHP
         .  .   ..:.:   : :  : .   ::.  .:  :.:.. :    .: .  :     
XP_011 --SLDTLQTRFARL---LAEYNATQMKMKQRLSQLESQVKGGGDKPLADGEVPGDATKTE
                700          710       720       730       740     

       1180      1190      1200      1210      1220      1230      
pF1KB7 KEAATDPPAPRTPPEPPGSPPSSPPPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGEQ
                                                                   
XP_011 DKQQ                                                        
                                                                   




1251 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 08:31:14 2016 done: Sat Nov  5 08:31:17 2016
 Total Scan time: 19.250 Total Display time:  0.270

Function used was FASTA [36.3.4 Apr, 2011]
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