Result of FASTA (omim) for pF1KE1043
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE1043, 470 aa
  1>>>pF1KE1043 470 - 470 aa - 470 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 7.2198+/-0.000452; mu= 11.5886+/- 0.028
 mean_var=372.2829+/-95.573, 0's: 0 Z-trim(118.1): 138  B-trim: 0 in 0/50
 Lambda= 0.066472
 statistics sampled from 30575 (30724) to 30575 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.706), E-opt: 0.2 (0.36), width:  16
 Scan time: 10.070

The best scores are:                                      opt bits E(85289)
NP_004286 (OMIM: 602464) TNF receptor-associated f ( 470) 3397 340.5 6.1e-93
XP_011523806 (OMIM: 602464) PREDICTED: TNF recepto ( 477) 3373 338.2   3e-92
XP_011523808 (OMIM: 602464) PREDICTED: TNF recepto ( 454) 3039 306.1 1.3e-82
XP_011523807 (OMIM: 602464) PREDICTED: TNF recepto ( 461) 3015 303.8 6.5e-82
XP_011523809 (OMIM: 602464) PREDICTED: TNF recepto ( 352) 2502 254.4 3.7e-67
XP_011523810 (OMIM: 602464) PREDICTED: TNF recepto ( 352) 2502 254.4 3.7e-67
NP_004611 (OMIM: 602355) TNF receptor-associated f ( 522)  641 76.2 2.3e-13
NP_665802 (OMIM: 602355) TNF receptor-associated f ( 522)  641 76.2 2.3e-13
XP_011517280 (OMIM: 601895) PREDICTED: TNF recepto ( 501)  416 54.6 7.2e-07
NP_066961 (OMIM: 601895) TNF receptor-associated f ( 501)  416 54.6 7.2e-07
XP_011517278 (OMIM: 601895) PREDICTED: TNF recepto ( 501)  416 54.6 7.2e-07
XP_016870584 (OMIM: 601895) PREDICTED: TNF recepto ( 501)  416 54.6 7.2e-07
XP_011517276 (OMIM: 601895) PREDICTED: TNF recepto ( 501)  416 54.6 7.2e-07
XP_011517279 (OMIM: 601895) PREDICTED: TNF recepto ( 501)  416 54.6 7.2e-07
XP_011517277 (OMIM: 601895) PREDICTED: TNF recepto ( 501)  416 54.6 7.2e-07
XP_016870583 (OMIM: 601895) PREDICTED: TNF recepto ( 533)  416 54.7 7.4e-07
XP_011517275 (OMIM: 601895) PREDICTED: TNF recepto ( 556)  416 54.7 7.6e-07
XP_016877109 (OMIM: 601896,614849) PREDICTED: TNF  ( 292)  388 51.5 3.6e-06
NP_663778 (OMIM: 601896,614849) TNF receptor-assoc ( 543)  382 51.4 7.2e-06
XP_016877108 (OMIM: 601896,614849) PREDICTED: TNF  ( 543)  382 51.4 7.2e-06
NP_001177876 (OMIM: 601711) TNF receptor-associate ( 294)  374 50.2 9.1e-06
NP_005649 (OMIM: 601711) TNF receptor-associated f ( 416)  374 50.5 1.1e-05
NP_001177874 (OMIM: 601711) TNF receptor-associate ( 416)  374 50.5 1.1e-05
XP_011535420 (OMIM: 601896,614849) PREDICTED: TNF  ( 485)  373 50.5 1.2e-05
NP_001186356 (OMIM: 601896,614849) TNF receptor-as ( 485)  373 50.5 1.2e-05
XP_011535419 (OMIM: 601896,614849) PREDICTED: TNF  ( 512)  373 50.5 1.3e-05
XP_011535418 (OMIM: 601896,614849) PREDICTED: TNF  ( 516)  373 50.5 1.3e-05
XP_016873709 (OMIM: 602355) PREDICTED: TNF recepto ( 324)  369 49.8 1.3e-05
XP_016877107 (OMIM: 601896,614849) PREDICTED: TNF  ( 568)  373 50.6 1.3e-05
XP_016877106 (OMIM: 601896,614849) PREDICTED: TNF  ( 568)  373 50.6 1.3e-05
NP_003291 (OMIM: 601896,614849) TNF receptor-assoc ( 568)  373 50.6 1.3e-05
NP_663777 (OMIM: 601896,614849) TNF receptor-assoc ( 568)  373 50.6 1.3e-05
NP_665702 (OMIM: 602356) TNF receptor-associated f ( 557)  370 50.3 1.6e-05
NP_004610 (OMIM: 602356) TNF receptor-associated f ( 557)  370 50.3 1.6e-05
NP_001029082 (OMIM: 602356) TNF receptor-associate ( 557)  370 50.3 1.6e-05
XP_016857710 (OMIM: 602356) PREDICTED: TNF recepto ( 557)  370 50.3 1.6e-05
NP_001306136 (OMIM: 602356) TNF receptor-associate ( 568)  370 50.3 1.6e-05
XP_011508261 (OMIM: 602356) PREDICTED: TNF recepto ( 568)  370 50.3 1.6e-05
XP_011508262 (OMIM: 602356) PREDICTED: TNF recepto ( 568)  370 50.3 1.6e-05
XP_011508259 (OMIM: 602356) PREDICTED: TNF recepto ( 631)  370 50.4 1.7e-05


>>NP_004286 (OMIM: 602464) TNF receptor-associated facto  (470 aa)
 initn: 3397 init1: 3397 opt: 3397  Z-score: 1789.5  bits: 340.5 E(85289): 6.1e-93
Smith-Waterman score: 3397; 100.0% identity (100.0% similar) in 470 aa overlap (1-470:1-470)

               10        20        30        40        50        60
pF1KE1 MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 LDYAKIYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LDYAKIYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMK
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 LSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGARMMRRLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGARMMRRLL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE1 AQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLK
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE1 DSCNTALVLCPFKDSGCKHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQELRRELE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DSCNTALVLCPFKDSGCKHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQELRRELE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE1 ELSVGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ELSVGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEG
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE1 THLSLYIRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 THLSLYIRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKP
              370       380       390       400       410       420

              430       440       450       460       470
pF1KE1 GTWRGSLDESSLGFGYPKFISHQDIRKRNYVRDDAVFIRAAVELPRKILS
       ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GTWRGSLDESSLGFGYPKFISHQDIRKRNYVRDDAVFIRAAVELPRKILS
              430       440       450       460       470

>>XP_011523806 (OMIM: 602464) PREDICTED: TNF receptor-as  (477 aa)
 initn: 2928 init1: 2928 opt: 3373  Z-score: 1777.0  bits: 338.2 E(85289): 3e-92
Smith-Waterman score: 3373; 98.5% identity (98.5% similar) in 477 aa overlap (1-470:1-477)

               10        20        30        40        50        60
pF1KE1 MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLP
               10        20        30        40        50        60

                      70        80        90       100       110   
pF1KE1 LDYAK-------IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPC
       :::::       ::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDYAKFPHPYPQIYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPC
               70        80        90       100       110       120

           120       130       140       150       160       170   
pF1KE1 PNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGA
              130       140       150       160       170       180

           180       190       200       210       220       230   
pF1KE1 RMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVARE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVARE
              190       200       210       220       230       240

           240       250       260       270       280       290   
pF1KE1 DLPGHLKDSCNTALVLCPFKDSGCKHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLPGHLKDSCNTALVLCPFKDSGCKHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQ
              250       260       270       280       290       300

           300       310       320       330       340       350   
pF1KE1 ELRRELEELSVGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELRRELEELSVGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLN
              310       320       330       340       350       360

           360       370       380       390       400       410   
pF1KE1 GNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPN
              370       380       390       400       410       420

           420       430       440       450       460       470
pF1KE1 WKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKRNYVRDDAVFIRAAVELPRKILS
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKRNYVRDDAVFIRAAVELPRKILS
              430       440       450       460       470       

>>XP_011523808 (OMIM: 602464) PREDICTED: TNF receptor-as  (454 aa)
 initn: 3039 init1: 3039 opt: 3039  Z-score: 1604.1  bits: 306.1 E(85289): 1.3e-82
Smith-Waterman score: 3039; 100.0% identity (100.0% similar) in 423 aa overlap (48-470:32-454)

        20        30        40        50        60        70       
pF1KE1 CPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYAKIYPDPELEVQVL
                                     ::::::::::::::::::::::::::::::
XP_011 PGMCDWPWLGSARACRQKEACQQAPWVLTASEGVFKCPEDQLPLDYAKIYPDPELEVQVL
              10        20        30        40        50        60 

        80        90       100       110       120       130       
pF1KE1 GLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKR
              70        80        90       100       110       120 

       140       150       160       170       180       190       
pF1KE1 RLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTY
             130       140       150       160       170       180 

       200       210       220       230       240       250       
pF1KE1 CTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGC
             190       200       210       220       230       240 

       260       270       280       290       300       310       
pF1KE1 KHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSDGVLIWKIGSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSDGVLIWKIGSY
             250       260       270       280       290       300 

       320       330       340       350       360       370       
pF1KE1 GRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNL
             310       320       330       340       350       360 

       380       390       400       410       420       430       
pF1KE1 LEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYP
             370       380       390       400       410       420 

       440       450       460       470
pF1KE1 KFISHQDIRKRNYVRDDAVFIRAAVELPRKILS
       :::::::::::::::::::::::::::::::::
XP_011 KFISHQDIRKRNYVRDDAVFIRAAVELPRKILS
             430       440       450    

>>XP_011523807 (OMIM: 602464) PREDICTED: TNF receptor-as  (461 aa)
 initn: 2928 init1: 2928 opt: 3015  Z-score: 1591.6  bits: 303.8 E(85289): 6.5e-82
Smith-Waterman score: 3015; 98.4% identity (98.4% similar) in 430 aa overlap (48-470:32-461)

        20        30        40        50        60               70
pF1KE1 CPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYAK-------IYPDP
                                     ::::::::::::::::::       :::::
XP_011 PGMCDWPWLGSARACRQKEACQQAPWVLTASEGVFKCPEDQLPLDYAKFPHPYPQIYPDP
              10        20        30        40        50        60 

               80        90       100       110       120       130
pF1KE1 ELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHL
              70        80        90       100       110       120 

              140       150       160       170       180       190
pF1KE1 QHDCPKRRLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QHDCPKRRLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPK
             130       140       150       160       170       180 

              200       210       220       230       240       250
pF1KE1 RTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLC
             190       200       210       220       230       240 

              260       270       280       290       300       310
pF1KE1 PFKDSGCKHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSDGVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFKDSGCKHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSDGVL
             250       260       270       280       290       300 

              320       330       340       350       360       370
pF1KE1 IWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVL
             310       320       330       340       350       360 

              380       390       400       410       420       430
pF1KE1 PGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDES
             370       380       390       400       410       420 

              440       450       460       470
pF1KE1 SLGFGYPKFISHQDIRKRNYVRDDAVFIRAAVELPRKILS
       ::::::::::::::::::::::::::::::::::::::::
XP_011 SLGFGYPKFISHQDIRKRNYVRDDAVFIRAAVELPRKILS
             430       440       450       460 

>>XP_011523809 (OMIM: 602464) PREDICTED: TNF receptor-as  (352 aa)
 initn: 2502 init1: 2502 opt: 2502  Z-score: 1326.7  bits: 254.4 E(85289): 3.7e-67
Smith-Waterman score: 2502; 100.0% identity (100.0% similar) in 352 aa overlap (119-470:1-352)

       90       100       110       120       130       140        
pF1KE1 GCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDF
                                     ::::::::::::::::::::::::::::::
XP_011                               MKLSRRDLPAHLQHDCPKRRLKCEFCGCDF
                                             10        20        30

      150       160       170       180       190       200        
pF1KE1 SGEAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGEAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQ
               40        50        60        70        80        90

      210       220       230       240       250       260        
pF1KE1 SHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCPKLAMAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCPKLAMAR
              100       110       120       130       140       150

      270       280       290       300       310       320        
pF1KE1 HVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSDGVLIWKIGSYGRRLQEAKAKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSDGVLIWKIGSYGRRLQEAKAKP
              160       170       180       190       200       210

      330       340       350       360       370       380        
pF1KE1 NLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTF
              220       230       240       250       260       270

      390       400       410       420       430       440        
pF1KE1 SLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKR
              280       290       300       310       320       330

      450       460       470
pF1KE1 NYVRDDAVFIRAAVELPRKILS
       ::::::::::::::::::::::
XP_011 NYVRDDAVFIRAAVELPRKILS
              340       350  

>>XP_011523810 (OMIM: 602464) PREDICTED: TNF receptor-as  (352 aa)
 initn: 2502 init1: 2502 opt: 2502  Z-score: 1326.7  bits: 254.4 E(85289): 3.7e-67
Smith-Waterman score: 2502; 100.0% identity (100.0% similar) in 352 aa overlap (119-470:1-352)

       90       100       110       120       130       140        
pF1KE1 GCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDF
                                     ::::::::::::::::::::::::::::::
XP_011                               MKLSRRDLPAHLQHDCPKRRLKCEFCGCDF
                                             10        20        30

      150       160       170       180       190       200        
pF1KE1 SGEAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGEAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQ
               40        50        60        70        80        90

      210       220       230       240       250       260        
pF1KE1 SHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCPKLAMAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCPKLAMAR
              100       110       120       130       140       150

      270       280       290       300       310       320        
pF1KE1 HVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSDGVLIWKIGSYGRRLQEAKAKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSDGVLIWKIGSYGRRLQEAKAKP
              160       170       180       190       200       210

      330       340       350       360       370       380        
pF1KE1 NLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTF
              220       230       240       250       260       270

      390       400       410       420       430       440        
pF1KE1 SLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKR
              280       290       300       310       320       330

      450       460       470
pF1KE1 NYVRDDAVFIRAAVELPRKILS
       ::::::::::::::::::::::
XP_011 NYVRDDAVFIRAAVELPRKILS
              340       350  

>>NP_004611 (OMIM: 602355) TNF receptor-associated facto  (522 aa)
 initn: 711 init1: 143 opt: 641  Z-score: 360.8  bits: 76.2 E(85289): 2.3e-13
Smith-Waterman score: 746; 26.7% identity (58.0% similar) in 469 aa overlap (1-462:53-499)

                                             10        20        30
pF1KE1                               MPGFDYKFLEKPKRRLLCPLCGKPMREPVQ
                                     . :.: .:    . .  ::.:   .:: ::
NP_004 MASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQ
             30        40        50        60        70        80  

               40        50        60        70        80        90
pF1KE1 VSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYAKIYPDPELEVQVLGLPIRCIHSEEGC
        . :::::: .:. . . ..  ::: :.  :   ...::   . ..:.: ..:   .:::
NP_004 -TPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKC--PNEGC
              90       100       110       120       130           

              100       110       120       130       140       150
pF1KE1 RWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSG
         .  ::::. :   : : .. :: .:   ...  .  :. .:::.:...:. :. ... 
NP_004 LHKMELRHLEDHQAHCEFALMDCP-QCQRPFQKFHINIHILKDCPRRQVSCDNCAASMAF
     140       150       160        170       180       190        

              160       170       180       190           200      
pF1KE1 EAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTY----CTKEFVFDT
       :  : :.  ::  .: ::  :.. ..:. . .:   .::    :::.    : ...  . 
NP_004 EDKEIHDQNCPLANVICEY-CNTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEKMQRNH
      200       210        220       230       240       250       

        210       220       230       240       250       260      
pF1KE1 IQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCP-KLA
       .  :  .  .  .    : .: ...     :....  :       :...   :.   .:.
NP_004 LARHLQENTQSHMRMLAQ-AVHSLSVIPDSGYISEVRN-------FQET--IHQLEGRLV
       260       270        280       290                300       

         270       280       290       300        310       320    
pF1KE1 MARHVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGS-DGVLIWKIGSYGRRLQEA
          :  . .  ..  .   ::. .. .. :. .. :. . . .:. :::::..: .:.  
NP_004 RQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNFGMHLKCQ
       310       320       330       340       350       360       

          330       340       350        360       370       380   
pF1KE1 KAKPNLECFSPAFYTHKYGYKLQVSAFLN-GNGSGEGTHLSLYIRVLPGAFDNLLEWPFA
       . .  .   ::.::: : :::: .   :.  ...  ....::..... : .:. : ::: 
NP_004 EEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQ
       370       380       390       400       410       420       

           390       400       410       420       430       440   
pF1KE1 RRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQ
         . ...::::.  . . .:  : .   :.   ::.:     .. ..  ::::  :.  .
NP_004 GTIRLTILDQSEAPV-RQNH-EEIMDAKPELLAFQRP-----TIPRNPKGFGYVTFMHLE
       430       440         450       460            470       480

           450       460       470               
pF1KE1 DIRKRNYVRDDAVFIRAAVELPRKILS               
        .:.:....::....:  :                       
NP_004 ALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV
              490       500       510       520  

>>NP_665802 (OMIM: 602355) TNF receptor-associated facto  (522 aa)
 initn: 711 init1: 143 opt: 641  Z-score: 360.8  bits: 76.2 E(85289): 2.3e-13
Smith-Waterman score: 746; 26.7% identity (58.0% similar) in 469 aa overlap (1-462:53-499)

                                             10        20        30
pF1KE1                               MPGFDYKFLEKPKRRLLCPLCGKPMREPVQ
                                     . :.: .:    . .  ::.:   .:: ::
NP_665 MASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQ
             30        40        50        60        70        80  

               40        50        60        70        80        90
pF1KE1 VSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYAKIYPDPELEVQVLGLPIRCIHSEEGC
        . :::::: .:. . . ..  ::: :.  :   ...::   . ..:.: ..:   .:::
NP_665 -TPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKC--PNEGC
              90       100       110       120       130           

              100       110       120       130       140       150
pF1KE1 RWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSG
         .  ::::. :   : : .. :: .:   ...  .  :. .:::.:...:. :. ... 
NP_665 LHKMELRHLEDHQAHCEFALMDCP-QCQRPFQKFHINIHILKDCPRRQVSCDNCAASMAF
     140       150       160        170       180       190        

              160       170       180       190           200      
pF1KE1 EAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTY----CTKEFVFDT
       :  : :.  ::  .: ::  :.. ..:. . .:   .::    :::.    : ...  . 
NP_665 EDKEIHDQNCPLANVICEY-CNTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEKMQRNH
      200       210        220       230       240       250       

        210       220       230       240       250       260      
pF1KE1 IQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCP-KLA
       .  :  .  .  .    : .: ...     :....  :       :...   :.   .:.
NP_665 LARHLQENTQSHMRMLAQ-AVHSLSVIPDSGYISEVRN-------FQET--IHQLEGRLV
       260       270        280       290                300       

         270       280       290       300        310       320    
pF1KE1 MARHVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGS-DGVLIWKIGSYGRRLQEA
          :  . .  ..  .   ::. .. .. :. .. :. . . .:. :::::..: .:.  
NP_665 RQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNFGMHLKCQ
       310       320       330       340       350       360       

          330       340       350        360       370       380   
pF1KE1 KAKPNLECFSPAFYTHKYGYKLQVSAFLN-GNGSGEGTHLSLYIRVLPGAFDNLLEWPFA
       . .  .   ::.::: : :::: .   :.  ...  ....::..... : .:. : ::: 
NP_665 EEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQ
       370       380       390       400       410       420       

           390       400       410       420       430       440   
pF1KE1 RRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQ
         . ...::::.  . . .:  : .   :.   ::.:     .. ..  ::::  :.  .
NP_665 GTIRLTILDQSEAPV-RQNH-EEIMDAKPELLAFQRP-----TIPRNPKGFGYVTFMHLE
       430       440         450       460            470       480

           450       460       470               
pF1KE1 DIRKRNYVRDDAVFIRAAVELPRKILS               
        .:.:....::....:  :                       
NP_665 ALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV
              490       500       510       520  

>>XP_011517280 (OMIM: 601895) PREDICTED: TNF receptor-as  (501 aa)
 initn: 729 init1: 333 opt: 416  Z-score: 244.3  bits: 54.6 E(85289): 7.2e-07
Smith-Waterman score: 785; 30.8% identity (56.5% similar) in 503 aa overlap (2-464:17-498)

                               10        20        30        40    
pF1KE1                MPGFDYKFL-EKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQ
                       :::.  .:  : . . ::  : . .:.: :.. ::::.:. :: 
XP_011 MAAASVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQ-CGHRYCSFCLA
               10        20        30        40         50         

           50                60         70        80        90     
pF1KE1 EFLSEGVFKCP--------EDQLP-LDYAKIYPDPELEVQVLGLPIRCIHSEEGCRWSGP
        .:: :  .:         :. .  :. .. .::   . .: .::  :    .:: :.: 
XP_011 SILSSGPQNCAACVHEGIYEEGISILESSSAFPDNAARREVESLPAVC--PSDGCTWKGT
      60        70        80        90       100         110       

         100        110       120       130       140       150    
pF1KE1 LRHLQG-HLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYE
       :.. .. : . : . .  ::  :   .   .   ::.:.::.: :.:. :     :   .
XP_011 LKEYESCHEGRCPLMLTECPA-CKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVK
       120       130        140       150       160       170      

          160       170       180       190           200       210
pF1KE1 SHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTY----CTKEFVFDTIQSH
       .:. .::.  . :.. :: . . :   :  .. : :   :: .    : .    .  : :
XP_011 AHHEVCPKFPLTCDG-CGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEH
        180       190        200       210       220       230     

              220       230       240       250                 260
pF1KE1 QYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCP--------FKDSGC--KHR
       . :  :  .:   .   ...  . : :  . . .  :  :         :..  :  ...
XP_011 EVQWLREHLA---MLLSSVLEAKPLLGDQSHAGSELLQRCESLEKKTATFENIVCVLNRE
         240          250       260       270       280       290  

              270          280       290                 300       
pF1KE1 CPKLAMARHVEESVKPH---LAMMCALVSRQRQ----------ELQELRRELEELSVGS-
         ..::.  .:   . :      . :: :. .:           . .:.... :. ... 
XP_011 VERVAMT--AEACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTY
              300       310       320       330       340       350

        310       320       330       340       350       360      
pF1KE1 DGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLY
       :::.::::....:. ::: :      ::::::: .::::. .  .:::.:.:.::::::.
XP_011 DGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLF
              360       370       380       390       400       410

        370       380       390       400       410       420      
pF1KE1 IRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGS
       . :. :  : ::.::: ..::. ::::..      .:: ..:.:: . ..::.:      
XP_011 FVVMKGPNDALLRWPFNQKVTLMLLDQNNR-----EHVIDAFRPDVTSSSFQRP------
              420       430       440            450               

        430       440        450       460       470
pF1KE1 LDESSLGFGYPKFISHQDIRKRN-YVRDDAVFIRAAVELPRKILS
       ... ... : : :   . .. .: ::::::.::.: :.:      
XP_011 VNDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDLTGL   
     460       470       480       490       500    

>>NP_066961 (OMIM: 601895) TNF receptor-associated facto  (501 aa)
 initn: 729 init1: 333 opt: 416  Z-score: 244.3  bits: 54.6 E(85289): 7.2e-07
Smith-Waterman score: 785; 30.8% identity (56.5% similar) in 503 aa overlap (2-464:17-498)

                               10        20        30        40    
pF1KE1                MPGFDYKFL-EKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQ
                       :::.  .:  : . . ::  : . .:.: :.. ::::.:. :: 
NP_066 MAAASVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQ-CGHRYCSFCLA
               10        20        30        40         50         

           50                60         70        80        90     
pF1KE1 EFLSEGVFKCP--------EDQLP-LDYAKIYPDPELEVQVLGLPIRCIHSEEGCRWSGP
        .:: :  .:         :. .  :. .. .::   . .: .::  :    .:: :.: 
NP_066 SILSSGPQNCAACVHEGIYEEGISILESSSAFPDNAARREVESLPAVC--PSDGCTWKGT
      60        70        80        90       100         110       

         100        110       120       130       140       150    
pF1KE1 LRHLQG-HLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYE
       :.. .. : . : . .  ::  :   .   .   ::.:.::.: :.:. :     :   .
NP_066 LKEYESCHEGRCPLMLTECPA-CKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVK
       120       130        140       150       160       170      

          160       170       180       190           200       210
pF1KE1 SHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTY----CTKEFVFDTIQSH
       .:. .::.  . :.. :: . . :   :  .. : :   :: .    : .    .  : :
NP_066 AHHEVCPKFPLTCDG-CGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEH
        180       190        200       210       220       230     

              220       230       240       250                 260
pF1KE1 QYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCP--------FKDSGC--KHR
       . :  :  .:   .   ...  . : :  . . .  :  :         :..  :  ...
NP_066 EVQWLREHLA---MLLSSVLEAKPLLGDQSHAGSELLQRCESLEKKTATFENIVCVLNRE
         240          250       260       270       280       290  

              270          280       290                 300       
pF1KE1 CPKLAMARHVEESVKPH---LAMMCALVSRQRQ----------ELQELRRELEELSVGS-
         ..::.  .:   . :      . :: :. .:           . .:.... :. ... 
NP_066 VERVAMT--AEACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTY
              300       310       320       330       340       350

        310       320       330       340       350       360      
pF1KE1 DGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLY
       :::.::::....:. ::: :      ::::::: .::::. .  .:::.:.:.::::::.
NP_066 DGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLF
              360       370       380       390       400       410

        370       380       390       400       410       420      
pF1KE1 IRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGS
       . :. :  : ::.::: ..::. ::::..      .:: ..:.:: . ..::.:      
NP_066 FVVMKGPNDALLRWPFNQKVTLMLLDQNNR-----EHVIDAFRPDVTSSSFQRP------
              420       430       440            450               

        430       440        450       460       470
pF1KE1 LDESSLGFGYPKFISHQDIRKRN-YVRDDAVFIRAAVELPRKILS
       ... ... : : :   . .. .: ::::::.::.: :.:      
NP_066 VNDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDLTGL   
     460       470       480       490       500    




470 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 07:44:55 2016 done: Sat Nov  5 07:44:56 2016
 Total Scan time: 10.070 Total Display time:  0.100

Function used was FASTA [36.3.4 Apr, 2011]
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