Result of FASTA (omim) for pF1KB3044
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB3044, 624 aa
  1>>>pF1KB3044 624 - 624 aa - 624 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.2116+/-0.000424; mu= 15.3330+/- 0.026
 mean_var=101.8880+/-20.352, 0's: 0 Z-trim(113.0): 128  B-trim: 704 in 1/53
 Lambda= 0.127061
 statistics sampled from 22014 (22145) to 22014 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.626), E-opt: 0.2 (0.26), width:  16
 Scan time: 10.240

The best scores are:                                      opt bits E(85289)
XP_006714576 (OMIM: 604677,616351) PREDICTED: coll ( 624) 4214 783.7       0
NP_005704 (OMIM: 604677,616351) collagen type IV a ( 624) 4214 783.7       0
NP_001123577 (OMIM: 604677,616351) collagen type I ( 752) 4214 783.7       0
XP_011541392 (OMIM: 604677,616351) PREDICTED: coll ( 631) 3938 733.1  7e-211
XP_016864408 (OMIM: 604677,616351) PREDICTED: coll ( 598) 2509 471.1 4.8e-132
NP_112729 (OMIM: 604677,616351) collagen type IV a ( 598) 2509 471.1 4.8e-132
XP_011541393 (OMIM: 604677,616351) PREDICTED: coll ( 605) 2509 471.1 4.8e-132
XP_011538903 (OMIM: 606737) PREDICTED: oxysterol-b ( 736)  288 64.1   2e-09
XP_011538902 (OMIM: 606737) PREDICTED: oxysterol-b ( 749)  288 64.1 2.1e-09
NP_683707 (OMIM: 606737) oxysterol-binding protein ( 746)  286 63.7 2.7e-09
XP_011538901 (OMIM: 606737) PREDICTED: oxysterol-b ( 759)  286 63.7 2.7e-09
XP_016855707 (OMIM: 606737) PREDICTED: oxysterol-b ( 713)  263 59.5 4.8e-08
NP_683706 (OMIM: 606737) oxysterol-binding protein ( 723)  263 59.5 4.8e-08
XP_006710381 (OMIM: 606737) PREDICTED: oxysterol-b ( 726)  263 59.5 4.9e-08
NP_078862 (OMIM: 606737) oxysterol-binding protein ( 736)  263 59.5 4.9e-08
NP_002547 (OMIM: 167040) oxysterol-binding protein ( 807)  261 59.1 6.8e-08
XP_011513897 (OMIM: 608639) PREDICTED: pleckstrin  ( 439)  252 57.3 1.3e-07
NP_116028 (OMIM: 608639) pleckstrin homology domai ( 440)  252 57.3 1.3e-07
XP_016868234 (OMIM: 608639) PREDICTED: pleckstrin  ( 441)  252 57.3 1.3e-07
XP_011513896 (OMIM: 608639) PREDICTED: pleckstrin  ( 455)  252 57.3 1.4e-07
XP_005249954 (OMIM: 608639) PREDICTED: pleckstrin  ( 459)  252 57.3 1.4e-07
NP_001183956 (OMIM: 608639) pleckstrin homology do ( 459)  252 57.3 1.4e-07
XP_011513894 (OMIM: 608639) PREDICTED: pleckstrin  ( 475)  252 57.3 1.4e-07
XP_016868233 (OMIM: 608639) PREDICTED: pleckstrin  ( 491)  252 57.3 1.4e-07
XP_011513893 (OMIM: 608639) PREDICTED: pleckstrin  ( 491)  252 57.3 1.4e-07
NP_001183955 (OMIM: 608639) pleckstrin homology do ( 519)  252 57.3 1.5e-07
NP_061964 (OMIM: 607774) pleckstrin homology domai ( 300)  247 56.3 1.8e-07
XP_016884198 (OMIM: 606729) PREDICTED: oxysterol-b ( 818)  245 56.2 5.2e-07
XP_011528361 (OMIM: 606729) PREDICTED: oxysterol-b ( 819)  245 56.2 5.3e-07
XP_006724266 (OMIM: 606729) PREDICTED: oxysterol-b ( 866)  245 56.2 5.5e-07
XP_016884197 (OMIM: 606729) PREDICTED: oxysterol-b ( 867)  245 56.2 5.5e-07
XP_005261522 (OMIM: 606729) PREDICTED: oxysterol-b ( 874)  245 56.2 5.5e-07
XP_011528360 (OMIM: 606729) PREDICTED: oxysterol-b ( 905)  245 56.2 5.7e-07
XP_011528359 (OMIM: 606729) PREDICTED: oxysterol-b ( 906)  245 56.2 5.7e-07
NP_001269668 (OMIM: 606729) oxysterol-binding prot ( 915)  245 56.2 5.7e-07
NP_110385 (OMIM: 606729) oxysterol-binding protein ( 916)  245 56.2 5.7e-07
NP_073613 (OMIM: 606739) oxysterol-binding protein ( 747)  213 50.3 2.8e-05
NP_060254 (OMIM: 606738) oxysterol-binding protein ( 764)  176 43.5  0.0032
XP_005264900 (OMIM: 606738) PREDICTED: oxysterol-b ( 769)  176 43.5  0.0032
NP_001167531 (OMIM: 606738) oxysterol-binding prot ( 700)  170 42.4  0.0064
XP_005264901 (OMIM: 606738) PREDICTED: oxysterol-b ( 705)  170 42.4  0.0064
XP_005252887 (OMIM: 604762) PREDICTED: switch-asso ( 436)  166 41.5  0.0073
NP_001284643 (OMIM: 604762) switch-associated prot ( 527)  166 41.6  0.0085
XP_016858842 (OMIM: 612723) PREDICTED: pleckstrin  ( 930)  169 42.3  0.0091
NP_055870 (OMIM: 604762) switch-associated protein ( 585)  166 41.6  0.0092
XP_016858841 (OMIM: 612723) PREDICTED: pleckstrin  (1013)  169 42.3  0.0097


>>XP_006714576 (OMIM: 604677,616351) PREDICTED: collagen  (624 aa)
 initn: 4214 init1: 4214 opt: 4214  Z-score: 4180.5  bits: 783.7 E(85289):    0
Smith-Waterman score: 4214; 100.0% identity (100.0% similar) in 624 aa overlap (1-624:1-624)

               10        20        30        40        50        60
pF1KB3 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 TEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 YGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 YFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGID
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGID
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 FKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKK
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 KSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 SVGTHRFVQKPYSRSSSMSSIDLVSASDDVHRFSSQVEEMVQNHMTYSLQDVGGDANWQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SVGTHRFVQKPYSRSSSMSSIDLVSASDDVHRFSSQVEEMVQNHMTYSLQDVGGDANWQL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 VVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHV
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 VETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 NNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKR
              550       560       570       580       590       600

              610       620    
pF1KB3 EYPKFLKRFTSYVQEKTAGKPILF
       ::::::::::::::::::::::::
XP_006 EYPKFLKRFTSYVQEKTAGKPILF
              610       620    

>>NP_005704 (OMIM: 604677,616351) collagen type IV alpha  (624 aa)
 initn: 4214 init1: 4214 opt: 4214  Z-score: 4180.5  bits: 783.7 E(85289):    0
Smith-Waterman score: 4214; 100.0% identity (100.0% similar) in 624 aa overlap (1-624:1-624)

               10        20        30        40        50        60
pF1KB3 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 TEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 YGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 YFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGID
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGID
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 FKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 FKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKK
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 KSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 SVGTHRFVQKPYSRSSSMSSIDLVSASDDVHRFSSQVEEMVQNHMTYSLQDVGGDANWQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SVGTHRFVQKPYSRSSSMSSIDLVSASDDVHRFSSQVEEMVQNHMTYSLQDVGGDANWQL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 VVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHV
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 VETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 NNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKR
              550       560       570       580       590       600

              610       620    
pF1KB3 EYPKFLKRFTSYVQEKTAGKPILF
       ::::::::::::::::::::::::
NP_005 EYPKFLKRFTSYVQEKTAGKPILF
              610       620    

>>NP_001123577 (OMIM: 604677,616351) collagen type IV al  (752 aa)
 initn: 4214 init1: 4214 opt: 4214  Z-score: 4179.3  bits: 783.7 E(85289):    0
Smith-Waterman score: 4214; 100.0% identity (100.0% similar) in 624 aa overlap (1-624:129-752)

                                             10        20        30
pF1KB3                               MSDNQSWNSSGSEEDPETESGPPVERCGVL
                                     ::::::::::::::::::::::::::::::
NP_001 SPDPSPRGLGASSGAAEGAGAGLLLGCRASMSDNQSWNSSGSEEDPETESGPPVERCGVL
      100       110       120       130       140       150        

               40        50        60        70        80        90
pF1KB3 SKWTNYIHGWQDRWVVLKNNALSYYKSEDETEYGCRGSICLSKAVITPHDFDECRFDISV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKWTNYIHGWQDRWVVLKNNALSYYKSEDETEYGCRGSICLSKAVITPHDFDECRFDISV
      160       170       180       190       200       210        

              100       110       120       130       140       150
pF1KB3 NDSVWYLRAQDPDHRQQWIDAIEQHKTESGYGSESSLRRHGSMVSLVSGASGYSATSTSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NDSVWYLRAQDPDHRQQWIDAIEQHKTESGYGSESSLRRHGSMVSLVSGASGYSATSTSS
      220       230       240       250       260       270        

              160       170       180       190       200       210
pF1KB3 FKKGHSLREKLAEMETFRDILCRQVDTLQKYFDACADAVSKDELQRDKVVEDDEDDFPTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKKGHSLREKLAEMETFRDILCRQVDTLQKYFDACADAVSKDELQRDKVVEDDEDDFPTT
      280       290       300       310       320       330        

              220       230       240       250       260       270
pF1KB3 RSDGDFLHSTNGNKEKLFPHVTPKGINGIDFKGEAITFKATTAGILATLSHCIELMVKRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSDGDFLHSTNGNKEKLFPHVTPKGINGIDFKGEAITFKATTAGILATLSHCIELMVKRE
      340       350       360       370       380       390        

              280       290       300       310       320       330
pF1KB3 DSWQKRLDKETEKKRRTEEAYKNAMTELKKKSHFGGPDYEEGPNSLINEEEFFDAVEAAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSWQKRLDKETEKKRRTEEAYKNAMTELKKKSHFGGPDYEEGPNSLINEEEFFDAVEAAL
      400       410       420       430       440       450        

              340       350       360       370       380       390
pF1KB3 DRQDKIEEQSQSEKVRLHWPTSLPSGDAFSSVGTHRFVQKPYSRSSSMSSIDLVSASDDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRQDKIEEQSQSEKVRLHWPTSLPSGDAFSSVGTHRFVQKPYSRSSSMSSIDLVSASDDV
      460       470       480       490       500       510        

              400       410       420       430       440       450
pF1KB3 HRFSSQVEEMVQNHMTYSLQDVGGDANWQLVVEEGEMKVYRREVEENGIVLDPLKATHAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HRFSSQVEEMVQNHMTYSLQDVGGDANWQLVVEEGEMKVYRREVEENGIVLDPLKATHAV
      520       530       540       550       560       570        

              460       470       480       490       500       510
pF1KB3 KGVTGHEVCNYFWNVDVRNDWETTIENFHVVETLADNAIIIYQTHKRVWPASQRDVLYLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGVTGHEVCNYFWNVDVRNDWETTIENFHVVETLADNAIIIYQTHKRVWPASQRDVLYLS
      580       590       600       610       620       630        

              520       530       540       550       560       570
pF1KB3 VIRKIPALTENDPETWIVCNFSVDHDSAPLNNRCVRAKINVAMICQTLVSPPEGNQEISR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VIRKIPALTENDPETWIVCNFSVDHDSAPLNNRCVRAKINVAMICQTLVSPPEGNQEISR
      640       650       660       670       680       690        

              580       590       600       610       620    
pF1KB3 DNILCKITYVANVNPGGWAPASVLRAVAKREYPKFLKRFTSYVQEKTAGKPILF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DNILCKITYVANVNPGGWAPASVLRAVAKREYPKFLKRFTSYVQEKTAGKPILF
      700       710       720       730       740       750  

>>XP_011541392 (OMIM: 604677,616351) PREDICTED: collagen  (631 aa)
 initn: 3938 init1: 3938 opt: 3938  Z-score: 3907.0  bits: 733.1 E(85289): 7e-211
Smith-Waterman score: 3938; 100.0% identity (100.0% similar) in 583 aa overlap (1-583:1-583)

               10        20        30        40        50        60
pF1KB3 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 TEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 YGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 YFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGID
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGID
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 FKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKK
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 KSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 SVGTHRFVQKPYSRSSSMSSIDLVSASDDVHRFSSQVEEMVQNHMTYSLQDVGGDANWQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVGTHRFVQKPYSRSSSMSSIDLVSASDDVHRFSSQVEEMVQNHMTYSLQDVGGDANWQL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 VVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHV
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 VETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 NNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKR
       :::::::::::::::::::::::::::::::::::::::::::                 
XP_011 NNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVTEARLCDIPCWRKKEKK
              550       560       570       580       590       600

              610       620           
pF1KB3 EYPKFLKRFTSYVQEKTAGKPILF       
                                      
XP_011 KLNALSWNVGSIALSVAQDLGLVYKNDKILQ
              610       620       630 

>>XP_016864408 (OMIM: 604677,616351) PREDICTED: collagen  (598 aa)
 initn: 2509 init1: 2509 opt: 2509  Z-score: 2491.6  bits: 471.1 E(85289): 4.8e-132
Smith-Waterman score: 3989; 95.8% identity (95.8% similar) in 624 aa overlap (1-624:1-598)

               10        20        30        40        50        60
pF1KB3 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 TEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 YGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 YFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGID
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGID
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 FKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKK
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 KSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 SVGTHRFVQKPYSRSSSMSSIDLVSASDDVHRFSSQVEEMVQNHMTYSLQDVGGDANWQL
       ::::::::::                          ::::::::::::::::::::::::
XP_016 SVGTHRFVQK--------------------------VEEMVQNHMTYSLQDVGGDANWQL
              370                                 380       390    

              430       440       450       460       470       480
pF1KB3 VVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHV
          400       410       420       430       440       450    

              490       500       510       520       530       540
pF1KB3 VETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPL
          460       470       480       490       500       510    

              550       560       570       580       590       600
pF1KB3 NNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKR
          520       530       540       550       560       570    

              610       620    
pF1KB3 EYPKFLKRFTSYVQEKTAGKPILF
       ::::::::::::::::::::::::
XP_016 EYPKFLKRFTSYVQEKTAGKPILF
          580       590        

>>NP_112729 (OMIM: 604677,616351) collagen type IV alpha  (598 aa)
 initn: 2509 init1: 2509 opt: 2509  Z-score: 2491.6  bits: 471.1 E(85289): 4.8e-132
Smith-Waterman score: 3989; 95.8% identity (95.8% similar) in 624 aa overlap (1-624:1-598)

               10        20        30        40        50        60
pF1KB3 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 TEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 TEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 YGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 YGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 YFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGID
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 YFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGID
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 FKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 FKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKK
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 KSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 KSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 SVGTHRFVQKPYSRSSSMSSIDLVSASDDVHRFSSQVEEMVQNHMTYSLQDVGGDANWQL
       ::::::::::                          ::::::::::::::::::::::::
NP_112 SVGTHRFVQK--------------------------VEEMVQNHMTYSLQDVGGDANWQL
              370                                 380       390    

              430       440       450       460       470       480
pF1KB3 VVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 VVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHV
          400       410       420       430       440       450    

              490       500       510       520       530       540
pF1KB3 VETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 VETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPL
          460       470       480       490       500       510    

              550       560       570       580       590       600
pF1KB3 NNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 NNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKR
          520       530       540       550       560       570    

              610       620    
pF1KB3 EYPKFLKRFTSYVQEKTAGKPILF
       ::::::::::::::::::::::::
NP_112 EYPKFLKRFTSYVQEKTAGKPILF
          580       590        

>>XP_011541393 (OMIM: 604677,616351) PREDICTED: collagen  (605 aa)
 initn: 2509 init1: 2509 opt: 2509  Z-score: 2491.6  bits: 471.1 E(85289): 4.8e-132
Smith-Waterman score: 3713; 95.5% identity (95.5% similar) in 583 aa overlap (1-583:1-557)

               10        20        30        40        50        60
pF1KB3 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 TEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 YGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 YFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGID
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGID
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 FKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKK
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 KSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 SVGTHRFVQKPYSRSSSMSSIDLVSASDDVHRFSSQVEEMVQNHMTYSLQDVGGDANWQL
       ::::::::::                          ::::::::::::::::::::::::
XP_011 SVGTHRFVQK--------------------------VEEMVQNHMTYSLQDVGGDANWQL
              370                                 380       390    

              430       440       450       460       470       480
pF1KB3 VVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHV
          400       410       420       430       440       450    

              490       500       510       520       530       540
pF1KB3 VETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPL
          460       470       480       490       500       510    

              550       560       570       580       590       600
pF1KB3 NNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKR
       :::::::::::::::::::::::::::::::::::::::::::                 
XP_011 NNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVTEARLCDIPCWRKKEKK
          520       530       540       550       560       570    

              610       620           
pF1KB3 EYPKFLKRFTSYVQEKTAGKPILF       
                                      
XP_011 KLNALSWNVGSIALSVAQDLGLVYKNDKILQ
          580       590       600     

>>XP_011538903 (OMIM: 606737) PREDICTED: oxysterol-bindi  (736 aa)
 initn: 232 init1: 130 opt: 288  Z-score: 290.0  bits: 64.1 E(85289): 2e-09
Smith-Waterman score: 288; 35.0% identity (62.2% similar) in 180 aa overlap (28-201:7-181)

               10        20        30        40        50          
pF1KB3 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNA--LSYYKSE
                                  : :::::: ..::: :: ::  ::  :::: :.
XP_011                      MASIMEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSK
                                    10        20        30         

       60         70        80        90       100       110       
pF1KB3 DETEYGCR-GSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQ---
       :.   : : : . :  :::   : :.  : :.:........:.: :.:..:: :.:.   
XP_011 DKMMRGSRRGCVRLRGAVIGIDDEDDSTFTITVDQKTFHFQARDADEREKWIHALEETIL
      40        50        60        70        80        90         

          120       130       140       150       160       170    
pF1KB3 HKTESGYGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQ
       ..: .   : .    ..: .: :   :   . ...   . ... .::.: ... .:: .:
XP_011 RHTLQLQISTTLAFFQSSGISPVLEFSKIIGLDSGFVPSVQDFDKKLTEADAYLQILIEQ
     100       110       120       130       140       150         

          180       190       200       210       220       230    
pF1KB3 VDTLQKYFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPK
       .    : ::   .  ..:: :: ..::                                 
XP_011 L----KLFDDKLQNCKEDE-QRKSMVESIKHCIVLLQIAKSTINPVDAIYQPSPLEPVIS
     160           170        180       190       200       210    

>>XP_011538902 (OMIM: 606737) PREDICTED: oxysterol-bindi  (749 aa)
 initn: 232 init1: 130 opt: 288  Z-score: 289.9  bits: 64.1 E(85289): 2.1e-09
Smith-Waterman score: 288; 35.0% identity (62.2% similar) in 180 aa overlap (28-201:7-181)

               10        20        30        40        50          
pF1KB3 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNA--LSYYKSE
                                  : :::::: ..::: :: ::  ::  :::: :.
XP_011                      MASIMEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSK
                                    10        20        30         

       60         70        80        90       100       110       
pF1KB3 DETEYGCR-GSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQ---
       :.   : : : . :  :::   : :.  : :.:........:.: :.:..:: :.:.   
XP_011 DKMMRGSRRGCVRLRGAVIGIDDEDDSTFTITVDQKTFHFQARDADEREKWIHALEETIL
      40        50        60        70        80        90         

          120       130       140       150       160       170    
pF1KB3 HKTESGYGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQ
       ..: .   : .    ..: .: :   :   . ...   . ... .::.: ... .:: .:
XP_011 RHTLQLQISTTLAFFQSSGISPVLEFSKIIGLDSGFVPSVQDFDKKLTEADAYLQILIEQ
     100       110       120       130       140       150         

          180       190       200       210       220       230    
pF1KB3 VDTLQKYFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPK
       .    : ::   .  ..:: :: ..::                                 
XP_011 L----KLFDDKLQNCKEDE-QRKSMVESIKHCIVLLQIAKDQSNAEKHADGMISTINPVD
     160           170        180       190       200       210    

>>NP_683707 (OMIM: 606737) oxysterol-binding protein-rel  (746 aa)
 initn: 266 init1: 130 opt: 286  Z-score: 288.0  bits: 63.7 E(85289): 2.7e-09
Smith-Waterman score: 286; 34.8% identity (61.8% similar) in 178 aa overlap (28-199:7-179)

               10        20        30        40        50          
pF1KB3 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNA--LSYYKSE
                                  : :::::: ..::: :: ::  ::  :::: :.
NP_683                      MASIMEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSK
                                    10        20        30         

       60         70        80        90       100       110       
pF1KB3 DETEYGCR-GSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQ---
       :.   : : : . :  :::   : :.  : :.:........:.: :.:..:: :.:.   
NP_683 DKMMRGSRRGCVRLRGAVIGIDDEDDSTFTITVDQKTFHFQARDADEREKWIHALEETIL
      40        50        60        70        80        90         

          120       130       140       150       160       170    
pF1KB3 HKTESGYGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQ
       ..: .   : .    ..: .: :   :   . ...   . ... .::.: ... .:: .:
NP_683 RHTLQLQISTTLAFFQSSGISPVLEFSKIIGLDSGFVPSVQDFDKKLTEADAYLQILIEQ
     100       110       120       130       140       150         

          180       190       200       210       220       230    
pF1KB3 VDTLQKYFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPK
       .    : ::   .  ..:: :: :.                                   
NP_683 L----KLFDDKLQNCKEDE-QRKKIETLKETTNSMVESIKHCIVLLQIAKSTINPVDAIY
     160           170        180       190       200       210    




624 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 07:03:05 2016 done: Sat Nov  5 07:03:07 2016
 Total Scan time: 10.240 Total Display time:  0.130

Function used was FASTA [36.3.4 Apr, 2011]
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