Result of FASTA (omim) for pF1KE3971
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE3971, 454 aa
  1>>>pF1KE3971     454 - 454 aa - 454 aa
Library: /omim/omim.rfq.tfa
  64369986 residues in 92320 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 9.2687+/-0.000409; mu= -1.1374+/- 0.025
 mean_var=291.1317+/-59.533, 0's: 0 Z-trim(119.5): 169  B-trim: 0 in 0/52
 Lambda= 0.075167
 statistics sampled from 34656 (34888) to 34656 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.727), E-opt: 0.2 (0.378), width:  16
 Scan time:  4.830

The best scores are:                                      opt bits E(92320)
NP_001017408 (OMIM: 606845) Golgi-associated PDZ a ( 454) 2996 338.8   2e-92
NP_065132 (OMIM: 606845) Golgi-associated PDZ and  ( 462) 2970 335.9 1.4e-91
XP_024302264 (OMIM: 606845) Golgi-associated PDZ a ( 293) 1946 224.7 2.8e-58
NP_006741 (OMIM: 600027) beta-2-syntrophin [Homo s ( 540)  275 43.8  0.0015
XP_011515541 (OMIM: 600026) beta-1-syntrophin isof ( 382)  263 42.3  0.0029
NP_066301 (OMIM: 600026) beta-1-syntrophin [Homo s ( 538)  263 42.5  0.0037
XP_006723386 (OMIM: 612331) protein lin-7 homolog  ( 183)  250 40.6  0.0047
NP_071448 (OMIM: 612331) protein lin-7 homolog B i ( 207)  250 40.6  0.0051
NP_060832 (OMIM: 612332) protein lin-7 homolog C [ ( 197)  245 40.1  0.0072
NP_004655 (OMIM: 603380) protein lin-7 homolog A i ( 233)  244 40.0  0.0087


>>NP_001017408 (OMIM: 606845) Golgi-associated PDZ and c  (454 aa)
 initn: 2996 init1: 2996 opt: 2996  Z-score: 1780.9  bits: 338.8 E(92320): 2e-92
Smith-Waterman score: 2996; 100.0% identity (100.0% similar) in 454 aa overlap (1-454:1-454)

               10        20        30        40        50        60
pF1KE3 MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE3 DITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVH
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE3 DQLLQLHSIQLQLHAKTGQSADSGTIKAKLERELEANKKEKMKEAQLEAEVKLLRKENEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQLLQLHSIQLQLHAKTGQSADSGTIKAKLERELEANKKEKMKEAQLEAEVKLLRKENEA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE3 LRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHR
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE3 HKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE3 HGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE3 YVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTD
              370       380       390       400       410       420

              430       440       450    
pF1KE3 THENGDLGTASETPLDDGASKLDDLHTLYHKKSY
       ::::::::::::::::::::::::::::::::::
NP_001 THENGDLGTASETPLDDGASKLDDLHTLYHKKSY
              430       440       450    

>>NP_065132 (OMIM: 606845) Golgi-associated PDZ and coil  (462 aa)
 initn: 2023 init1: 2023 opt: 2970  Z-score: 1765.6  bits: 335.9 E(92320): 1.4e-91
Smith-Waterman score: 2970; 98.3% identity (98.3% similar) in 462 aa overlap (1-454:1-462)

               10        20        30        40        50        60
pF1KE3 MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE3 DITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 DITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVH
               70        80        90       100       110       120

              130       140       150               160       170  
pF1KE3 DQLLQLHSIQLQLHAKTGQSADSGTIKAKL--------ERELEANKKEKMKEAQLEAEVK
       ::::::::::::::::::::::::::::::        ::::::::::::::::::::::
NP_065 DQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVK
              130       140       150       160       170       180

            180       190       200       210       220       230  
pF1KE3 LLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQL
              190       200       210       220       230       240

            240       250       260       270       280       290  
pF1KE3 EAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 EAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLG
              250       260       270       280       290       300

            300       310       320       330       340       350  
pF1KE3 ISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQR
              310       320       330       340       350       360

            360       370       380       390       400       410  
pF1KE3 GEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 GEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQG
              370       380       390       400       410       420

            420       430       440       450    
pF1KE3 FNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY
       ::::::::::::::::::::::::::::::::::::::::::
NP_065 FNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY
              430       440       450       460  

>>XP_024302264 (OMIM: 606845) Golgi-associated PDZ and c  (293 aa)
 initn: 1946 init1: 1946 opt: 1946  Z-score: 1167.9  bits: 224.7 E(92320): 2.8e-58
Smith-Waterman score: 1946; 100.0% identity (100.0% similar) in 293 aa overlap (162-454:1-293)

             140       150       160       170       180       190 
pF1KE3 QLHAKTGQSADSGTIKAKLERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAE
                                     ::::::::::::::::::::::::::::::
XP_024                               MKEAQLEAEVKLLRKENEALRRHIAVLQAE
                                             10        20        30

             200       210       220       230       240       250 
pF1KE3 VYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 VYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGR
               40        50        60        70        80        90

             260       270       280       290       300       310 
pF1KE3 NDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 NDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIH
              100       110       120       130       140       150

             320       330       340       350       360       370 
pF1KE3 PGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 PGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDE
              160       170       180       190       200       210

             380       390       400       410       420       430 
pF1KE3 NVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDTHENGDLGTAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 NVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDTHENGDLGTAS
              220       230       240       250       260       270

             440       450    
pF1KE3 ETPLDDGASKLDDLHTLYHKKSY
       :::::::::::::::::::::::
XP_024 ETPLDDGASKLDDLHTLYHKKSY
              280       290   

>>NP_006741 (OMIM: 600027) beta-2-syntrophin [Homo sapie  (540 aa)
 initn: 348 init1: 275 opt: 275  Z-score: 185.2  bits: 43.8 E(92320): 0.0015
Smith-Waterman score: 275; 41.7% identity (72.8% similar) in 103 aa overlap (260-362:95-197)

     230       240       250       260       270       280         
pF1KE3 NQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHE
                                     .::.  .    .. .  :.:.: ..:..  
NP_006 PAAAAFNGLPNGGGAGDSLPGSPSRGLGPPSPPAPPRGPAGEAGASPPVRRVRVVKQEAG
           70        80        90       100       110       120    

     290       300       310       320       330       340         
pF1KE3 GLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILS
       :::::: ::.:. .:::::.: ::  ::.  .:..:::::.:::..::.. : .::  :.
NP_006 GLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAVQALK
          130       140       150       160       170       180    

     350       360       370       380       390       400         
pF1KE3 QQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKV
       .   :. .:: ..                                               
NP_006 RAGKEVLLEVKFIREVTPYIKKPSLVSDLPWEGAAPQSPSFSGSEDSGSPKHQNSTKDRK
          190       200       210       220       230       240    

>>XP_011515541 (OMIM: 600026) beta-1-syntrophin isoform   (382 aa)
 initn: 287 init1: 255 opt: 263  Z-score: 180.1  bits: 42.3 E(92320): 0.0029
Smith-Waterman score: 263; 53.6% identity (75.0% similar) in 84 aa overlap (279-362:111-194)

      250       260       270       280       290       300        
pF1KE3 RGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILIS
                                     : : .::..  :::::: ::::. .:::::
XP_011 GAQPPDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQELGGLGISIKGGKENKMPILIS
               90       100       110       120       130       140

      310       320       330       340       350       360        
pF1KE3 EIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDS
       .:  :  ::.  .:.::::::.:::..:::. : :::  :..   :. .:: :.      
XP_011 KIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKYMREATPY
              150       160       170       180       190       200

      370       380       390       400       410       420        
pF1KE3 DDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDTHENGDLG
                                                                   
XP_011 VKKGSPVSEIGWETPPPESPRLGGSTSDPPSSQSFSFHRDRKSIPLKMCYVTRSMALADP
              210       220       230       240       250       260

>>NP_066301 (OMIM: 600026) beta-1-syntrophin [Homo sapie  (538 aa)
 initn: 287 init1: 255 opt: 263  Z-score: 178.2  bits: 42.5 E(92320): 0.0037
Smith-Waterman score: 263; 53.6% identity (75.0% similar) in 84 aa overlap (279-362:111-194)

      250       260       270       280       290       300        
pF1KE3 RGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILIS
                                     : : .::..  :::::: ::::. .:::::
NP_066 GAQPPDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQELGGLGISIKGGKENKMPILIS
               90       100       110       120       130       140

      310       320       330       340       350       360        
pF1KE3 EIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDS
       .:  :  ::.  .:.::::::.:::..:::. : :::  :..   :. .:: :.      
NP_066 KIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKYMREATPY
              150       160       170       180       190       200

      370       380       390       400       410       420        
pF1KE3 DDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDTHENGDLG
                                                                   
NP_066 VKKGSPVSEIGWETPPPESPRLGGSTSDPPSSQSFSFHRDRKSIPLKMCYVTRSMALADP
              210       220       230       240       250       260

>>XP_006723386 (OMIM: 612331) protein lin-7 homolog B is  (183 aa)
 initn: 250 init1: 228 opt: 250  Z-score: 176.5  bits: 40.6 E(92320): 0.0047
Smith-Waterman score: 250; 41.6% identity (69.9% similar) in 113 aa overlap (272-384:61-170)

             250       260       270       280       290       300 
pF1KE3 KTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEH
                                     :.: .  : : : : : ::::..: ::::.
XP_006 PPQKLQALQRVLQSRFCSAIREATVAAFTASEGHAHPRVVELPKTD-EGLGFNIMGGKEQ
               40        50        60        70         80         

             310       320       330       340       350       360 
pF1KE3 GVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVY
       . :: ::.. ::  ::: :::. :: .:.::::...  .:..:: .:.  .: ... :: 
XP_006 NSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKL-VVR
      90       100       110       120       130       140         

             370       380       390       400       410       420 
pF1KE3 VAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDT
        .:.:  .. ....:   . : :                                     
XP_006 YTPRV-LEEMEARFEKMRSARRRQQHQSYSSLESRG                        
      150        160       170       180                           

>>NP_071448 (OMIM: 612331) protein lin-7 homolog B isofo  (207 aa)
 initn: 250 init1: 228 opt: 250  Z-score: 175.8  bits: 40.6 E(92320): 0.0051
Smith-Waterman score: 250; 41.6% identity (69.9% similar) in 113 aa overlap (272-384:85-194)

             250       260       270       280       290       300 
pF1KE3 KTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEH
                                     :.: .  : : : : : ::::..: ::::.
NP_071 EQLYDTLDITGSAEIRAHATAKATVAAFTASEGHAHPRVVELPKTD-EGLGFNIMGGKEQ
           60        70        80        90       100        110   

             310       320       330       340       350       360 
pF1KE3 GVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVY
       . :: ::.. ::  ::: :::. :: .:.::::...  .:..:: .:.  .: ... :: 
NP_071 NSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKL-VVR
           120       130       140       150       160        170  

             370       380       390       400       410       420 
pF1KE3 VAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDT
        .:.:  .. ....:   . : :                                     
NP_071 YTPRV-LEEMEARFEKMRSARRRQQHQSYSSLESRG                        
             180       190       200                               

>>NP_060832 (OMIM: 612332) protein lin-7 homolog C [Homo  (197 aa)
 initn: 253 init1: 229 opt: 245  Z-score: 173.1  bits: 40.1 E(92320): 0.0072
Smith-Waterman score: 245; 41.7% identity (73.8% similar) in 103 aa overlap (280-382:92-193)

     250       260       270       280       290       300         
pF1KE3 GRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISE
                                     .:. : . .::::..: ::::.. :: ::.
NP_060 DISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYISR
              70        80        90       100       110       120 

     310       320       330       340       350       360         
pF1KE3 IHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSD
       : ::  ::: :::. :: .:.::::...  .:..:: .:.  .:.... ::  .:.:  .
NP_060 IIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKL-VVRYTPKVLEE
             130       140       150       160        170       180

     370       380       390       400       410       420         
pF1KE3 DENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDTHENGDLGT
        :.   . .:..:                                               
NP_060 MESRFEKMRSAKRRQQT                                           
              190                                                  

>>NP_004655 (OMIM: 603380) protein lin-7 homolog A isofo  (233 aa)
 initn: 252 init1: 213 opt: 244  Z-score: 171.6  bits: 40.0 E(92320): 0.0087
Smith-Waterman score: 252; 31.1% identity (60.7% similar) in 196 aa overlap (202-384:25-209)

             180       190       200       210       220           
pF1KE3 KLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAH--DKLW
                                     ::...:  .. .. : .. . :.:  ..: 
NP_004       MLKPSVTSAPTADMATLTVVQPLTLDRDVARAIELLEKLQESGEVPVHKLQSLK
                     10        20        30        40        50    

     230              240           250       260       270        
pF1KE3 NQLEAE-------IHLHRHKTV-IRAC---RGRNDLKRPMQAPPGHDQDSLKKSQGVGPI
       . :..:       .. . :.:. . .:   :.:   :  . :        .  :.: .  
NP_004 KVLQSEFCTAIREVYQYMHETITVNGCPEFRARATAKATVAA--------FAASEGHSHP
           60        70        80        90               100      

      280       290       300       310       320       330        
pF1KE3 RKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD
       : : : : : ::::... ::::.. :: ::.: ::  :.: :::. :: .:.::::... 
NP_004 RVVELPKTD-EGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEG
        110        120       130       140       150       160     

      340       350       360       370       380       390        
pF1KE3 TKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGA
        .:..:: .:.  .  ... ::  .:.:  .. ....:     : :              
NP_004 EHHEKAVELLKAAKDSVKL-VVRYTPKV-LEEMEARFEKLRTARRRQQQQLLIQQQQQQQ
         170       180        190        200       210       220   

      400       410       420       430       440       450    
pF1KE3 SCKDTSGEIKVLQGFNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY
                                                               
NP_004 QQQTQQNHMS                                              
           230                                                 




454 residues in 1 query   sequences
64369986 residues in 92320 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Oct 24 21:28:54 2019 done: Thu Oct 24 21:28:55 2019
 Total Scan time:  4.830 Total Display time:  0.040

Function used was FASTA [36.3.4 Apr, 2011]
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