Result of FASTA (omim) for pF1KB4651
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB4651, 278 aa
  1>>>pF1KB4651 278 - 278 aa - 278 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 4.7734+/-0.000372; mu= 18.4166+/- 0.023
 mean_var=70.4683+/-14.157, 0's: 0 Z-trim(113.8): 68  B-trim: 0 in 0/53
 Lambda= 0.152784
 statistics sampled from 23194 (23262) to 23194 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.648), E-opt: 0.2 (0.273), width:  16
 Scan time:  6.820

The best scores are:                                      opt bits E(85289)
NP_060294 (OMIM: 610637) E3 ubiquitin-protein liga ( 278) 1906 429.1 4.5e-120
XP_011538188 (OMIM: 610637) PREDICTED: E3 ubiquiti ( 204) 1312 298.0 9.3e-81
NP_001096032 (OMIM: 613338) E3 ubiquitin-protein l ( 402)  170 46.6 9.1e-05
XP_011537797 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 291)  161 44.5 0.00028
NP_001002266 (OMIM: 613335) E3 ubiquitin-protein l ( 291)  161 44.5 0.00028
XP_016871383 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 291)  161 44.5 0.00028
NP_659458 (OMIM: 613335) E3 ubiquitin-protein liga ( 291)  161 44.5 0.00028
XP_011537796 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573)  161 44.7 0.00046
XP_011537794 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573)  161 44.7 0.00046
XP_005271861 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573)  161 44.7 0.00046
XP_006717767 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573)  161 44.7 0.00046
XP_011537795 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573)  161 44.7 0.00046
NP_001269795 (OMIM: 613335) E3 ubiquitin-protein l ( 573)  161 44.7 0.00046
NP_060393 (OMIM: 613331) E3 ubiquitin-protein liga ( 272)  157 43.6  0.0005
XP_016863825 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 285)  157 43.6 0.00051
XP_016863824 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 285)  157 43.6 0.00051
NP_001159845 (OMIM: 613331) E3 ubiquitin-protein l ( 289)  157 43.6 0.00052
XP_016863823 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 289)  157 43.6 0.00052
XP_011530357 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 545)  157 43.8 0.00082
NP_065865 (OMIM: 608208) E3 ubiquitin-protein liga ( 410)  153 42.8  0.0012
NP_612405 (OMIM: 613336) E3 ubiquitin-protein liga ( 346)  152 42.6  0.0013


>>NP_060294 (OMIM: 610637) E3 ubiquitin-protein ligase M  (278 aa)
 initn: 1906 init1: 1906 opt: 1906  Z-score: 2276.7  bits: 429.1 E(85289): 4.5e-120
Smith-Waterman score: 1906; 100.0% identity (100.0% similar) in 278 aa overlap (1-278:1-278)

               10        20        30        40        50        60
pF1KB4 MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVHQACLQRWVDEKQRGNST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVHQACLQRWVDEKQRGNST
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 ARVACPQCNAEYLIVFPKLGPVVYVLDLADRLISKACPFAAAGIMVGSIYWTAVTYGAVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ARVACPQCNAEYLIVFPKLGPVVYVLDLADRLISKACPFAAAGIMVGSIYWTAVTYGAVT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 VMQVVGHKEGLDVMERADPLFLLIGLPTIPVMLILGKMIRWEDYVLRLWRKYSNKLQILN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 VMQVVGHKEGLDVMERADPLFLLIGLPTIPVMLILGKMIRWEDYVLRLWRKYSNKLQILN
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 SIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTIATIVGKLMFSSVNSNLQRTIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTIATIVGKLMFSSVNSNLQRTIL
              190       200       210       220       230       240

              250       260       270        
pF1KB4 GGIAFVAIKGAFKVYFKQQQYLRQAHRKILNYPEQEEA
       ::::::::::::::::::::::::::::::::::::::
NP_060 GGIAFVAIKGAFKVYFKQQQYLRQAHRKILNYPEQEEA
              250       260       270        

>>XP_011538188 (OMIM: 610637) PREDICTED: E3 ubiquitin-pr  (204 aa)
 initn: 1312 init1: 1312 opt: 1312  Z-score: 1570.9  bits: 298.0 E(85289): 9.3e-81
Smith-Waterman score: 1312; 100.0% identity (100.0% similar) in 199 aa overlap (80-278:6-204)

      50        60        70        80        90       100         
pF1KB4 WVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYVLDLADRLISKACPFAAAGIMVGSI
                                     ::::::::::::::::::::::::::::::
XP_011                          MHKQRGPVVYVLDLADRLISKACPFAAAGIMVGSI
                                        10        20        30     

     110       120       130       140       150       160         
pF1KB4 YWTAVTYGAVTVMQVVGHKEGLDVMERADPLFLLIGLPTIPVMLILGKMIRWEDYVLRLW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YWTAVTYGAVTVMQVVGHKEGLDVMERADPLFLLIGLPTIPVMLILGKMIRWEDYVLRLW
          40        50        60        70        80        90     

     170       180       190       200       210       220         
pF1KB4 RKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTIATIVGKLMFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTIATIVGKLMFS
         100       110       120       130       140       150     

     230       240       250       260       270        
pF1KB4 SVNSNLQRTILGGIAFVAIKGAFKVYFKQQQYLRQAHRKILNYPEQEEA
       :::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVNSNLQRTILGGIAFVAIKGAFKVYFKQQQYLRQAHRKILNYPEQEEA
         160       170       180       190       200    

>>NP_001096032 (OMIM: 613338) E3 ubiquitin-protein ligas  (402 aa)
 initn: 152 init1: 129 opt: 170  Z-score: 206.6  bits: 46.6 E(85289): 9.1e-05
Smith-Waterman score: 189; 26.3% identity (53.2% similar) in 171 aa overlap (14-180:170-323)

                                10        20        30        40   
pF1KB4                  MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVH
                                     : .::   :.   .: . :::: ::....:
NP_001 ETRSVCSSRSSSSGGGDQRAGHQHQHHQPICKICFQGAEQ---GELLNPCRCDGSVRYTH
     140       150       160       170          180       190      

            50        60        70        80        90       100   
pF1KB4 QACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYVLDLADRLISKACPFAAAG
       : :: .:..:  ::. :    :  :  .: ..  :.       ...  :. :.  .:   
NP_001 QLCLLKWISE--RGSWT----CELCCYRYHVIAIKMKQPCQWQSISITLVEKVQMIA---
        200         210           220       230       240          

           110       120       130       140        150       160  
pF1KB4 IMVGSIYWTAVTYGAVTVMQVVGHKEGLDVMERADPLFLL-IGLPTIPVMLILGKMIRWE
       ...::..  :    .:: .   . .    : .: : :: .  :.  .  .. .: ...  
NP_001 VILGSLFLIA----SVTWLLWSAFSP-YAVWQRKDILFQICYGMYGFMDLVCIGLIVHEG
       250           260        270       280       290       300  

               170       180       190       200       210         
pF1KB4 DYVLRL---WRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTI
         : :.   ::  . . ..::                                       
NP_001 AAVYRVFKRWRAVNLHWDVLNYDKATDIEESSRGESSTSRTLWLPLTALRNRNLVHPTQL
            310       320       330       340       350       360  

>>XP_011537797 (OMIM: 613335) PREDICTED: E3 ubiquitin-pr  (291 aa)
 initn: 120 init1: 120 opt: 161  Z-score: 197.7  bits: 44.5 E(85289): 0.00028
Smith-Waterman score: 164; 23.9% identity (48.3% similar) in 180 aa overlap (14-189:80-242)

                                10        20        30        40   
pF1KB4                  MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVH
                                     : .:    .:.  .  . ::.: :: ..::
XP_011 SKAGSPPSASAPAPVSSFSRTSITPSSQDICRICHCEGDDE--SPLITPCHCTGSLHFVH
      50        60        70        80        90         100       

            50        60        70        80          90        100
pF1KB4 QACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYV--LDLADRLISKA-CPFA
       :::::.:.      .:.    :  :. :. :.  :: :.     :....    :  :  .
XP_011 QACLQQWI------KSSDTRCCELCKYEF-IMETKLKPLRKWEKLQMTSSERRKIMCSVT
       110             120       130        140       150       160

              110       120        130       140       150         
pF1KB4 AAGIMVGSIYWTAVTYGAVTVMQVV-GHKEGLDVMERADPLFLLIGLPTIPVMLILGKMI
          : .  . :.  .    :. ..  :.  :  ..:   :..  . . .:     :  : 
XP_011 FHVIAITCVVWSLYVLIDRTAEEIKQGQATG--ILEW--PFWTKLVVVAIGFTGGLLFMY
              170       180       190           200       210      

     160       170       180       190       200       210         
pF1KB4 RWEDYVLRLWRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTI
             ..::..    :.  : ..   .::                              
XP_011 VQCKVYVQLWKR----LKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENKHGYGICHSD
        220           230       240       250       260       270  

>>NP_001002266 (OMIM: 613335) E3 ubiquitin-protein ligas  (291 aa)
 initn: 120 init1: 120 opt: 161  Z-score: 197.7  bits: 44.5 E(85289): 0.00028
Smith-Waterman score: 164; 23.9% identity (48.3% similar) in 180 aa overlap (14-189:80-242)

                                10        20        30        40   
pF1KB4                  MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVH
                                     : .:    .:.  .  . ::.: :: ..::
NP_001 SKAGSPPSASAPAPVSSFSRTSITPSSQDICRICHCEGDDE--SPLITPCHCTGSLHFVH
      50        60        70        80        90         100       

            50        60        70        80          90        100
pF1KB4 QACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYV--LDLADRLISKA-CPFA
       :::::.:.      .:.    :  :. :. :.  :: :.     :....    :  :  .
NP_001 QACLQQWI------KSSDTRCCELCKYEF-IMETKLKPLRKWEKLQMTSSERRKIMCSVT
       110             120       130        140       150       160

              110       120        130       140       150         
pF1KB4 AAGIMVGSIYWTAVTYGAVTVMQVV-GHKEGLDVMERADPLFLLIGLPTIPVMLILGKMI
          : .  . :.  .    :. ..  :.  :  ..:   :..  . . .:     :  : 
NP_001 FHVIAITCVVWSLYVLIDRTAEEIKQGQATG--ILEW--PFWTKLVVVAIGFTGGLLFMY
              170       180       190           200       210      

     160       170       180       190       200       210         
pF1KB4 RWEDYVLRLWRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTI
             ..::..    :.  : ..   .::                              
NP_001 VQCKVYVQLWKR----LKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENKHGYGICHSD
        220           230       240       250       260       270  

>>XP_016871383 (OMIM: 613335) PREDICTED: E3 ubiquitin-pr  (291 aa)
 initn: 120 init1: 120 opt: 161  Z-score: 197.7  bits: 44.5 E(85289): 0.00028
Smith-Waterman score: 164; 23.9% identity (48.3% similar) in 180 aa overlap (14-189:80-242)

                                10        20        30        40   
pF1KB4                  MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVH
                                     : .:    .:.  .  . ::.: :: ..::
XP_016 SKAGSPPSASAPAPVSSFSRTSITPSSQDICRICHCEGDDE--SPLITPCHCTGSLHFVH
      50        60        70        80        90         100       

            50        60        70        80          90        100
pF1KB4 QACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYV--LDLADRLISKA-CPFA
       :::::.:.      .:.    :  :. :. :.  :: :.     :....    :  :  .
XP_016 QACLQQWI------KSSDTRCCELCKYEF-IMETKLKPLRKWEKLQMTSSERRKIMCSVT
       110             120       130        140       150       160

              110       120        130       140       150         
pF1KB4 AAGIMVGSIYWTAVTYGAVTVMQVV-GHKEGLDVMERADPLFLLIGLPTIPVMLILGKMI
          : .  . :.  .    :. ..  :.  :  ..:   :..  . . .:     :  : 
XP_016 FHVIAITCVVWSLYVLIDRTAEEIKQGQATG--ILEW--PFWTKLVVVAIGFTGGLLFMY
              170       180       190           200       210      

     160       170       180       190       200       210         
pF1KB4 RWEDYVLRLWRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTI
             ..::..    :.  : ..   .::                              
XP_016 VQCKVYVQLWKR----LKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENKHGYGICHSD
        220           230       240       250       260       270  

>>NP_659458 (OMIM: 613335) E3 ubiquitin-protein ligase M  (291 aa)
 initn: 120 init1: 120 opt: 161  Z-score: 197.7  bits: 44.5 E(85289): 0.00028
Smith-Waterman score: 164; 23.9% identity (48.3% similar) in 180 aa overlap (14-189:80-242)

                                10        20        30        40   
pF1KB4                  MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVH
                                     : .:    .:.  .  . ::.: :: ..::
NP_659 SKAGSPPSASAPAPVSSFSRTSITPSSQDICRICHCEGDDE--SPLITPCHCTGSLHFVH
      50        60        70        80        90         100       

            50        60        70        80          90        100
pF1KB4 QACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYV--LDLADRLISKA-CPFA
       :::::.:.      .:.    :  :. :. :.  :: :.     :....    :  :  .
NP_659 QACLQQWI------KSSDTRCCELCKYEF-IMETKLKPLRKWEKLQMTSSERRKIMCSVT
       110             120       130        140       150       160

              110       120        130       140       150         
pF1KB4 AAGIMVGSIYWTAVTYGAVTVMQVV-GHKEGLDVMERADPLFLLIGLPTIPVMLILGKMI
          : .  . :.  .    :. ..  :.  :  ..:   :..  . . .:     :  : 
NP_659 FHVIAITCVVWSLYVLIDRTAEEIKQGQATG--ILEW--PFWTKLVVVAIGFTGGLLFMY
              170       180       190           200       210      

     160       170       180       190       200       210         
pF1KB4 RWEDYVLRLWRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTI
             ..::..    :.  : ..   .::                              
NP_659 VQCKVYVQLWKR----LKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENKHGYGICHSD
        220           230       240       250       260       270  

>>XP_011537796 (OMIM: 613335) PREDICTED: E3 ubiquitin-pr  (573 aa)
 initn: 120 init1: 120 opt: 161  Z-score: 193.9  bits: 44.7 E(85289): 0.00046
Smith-Waterman score: 164; 23.9% identity (48.3% similar) in 180 aa overlap (14-189:362-524)

                                10        20        30        40   
pF1KB4                  MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVH
                                     : .:    .:.  .  . ::.: :: ..::
XP_011 STEKDSDLDCPSPFSEKLPPISPVSTSGDVCRICHCEGDDE--SPLITPCHCTGSLHFVH
             340       350       360       370         380         

            50        60        70        80          90        100
pF1KB4 QACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYV--LDLADRLISKA-CPFA
       :::::.:.      .:.    :  :. :. :.  :: :.     :....    :  :  .
XP_011 QACLQQWI------KSSDTRCCELCKYEF-IMETKLKPLRKWEKLQMTSSERRKIMCSVT
     390             400       410        420       430       440  

              110       120        130       140       150         
pF1KB4 AAGIMVGSIYWTAVTYGAVTVMQVV-GHKEGLDVMERADPLFLLIGLPTIPVMLILGKMI
          : .  . :.  .    :. ..  :.  :  ..:   :..  . . .:     :  : 
XP_011 FHVIAITCVVWSLYVLIDRTAEEIKQGQATG--ILEW--PFWTKLVVVAIGFTGGLLFMY
            450       460       470           480       490        

     160       170       180       190       200       210         
pF1KB4 RWEDYVLRLWRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTI
             ..::..    :.  : ..   .::                              
XP_011 VQCKVYVQLWKR----LKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENKHGYGICHSD
      500       510           520       530       540       550    

>>XP_011537794 (OMIM: 613335) PREDICTED: E3 ubiquitin-pr  (573 aa)
 initn: 120 init1: 120 opt: 161  Z-score: 193.9  bits: 44.7 E(85289): 0.00046
Smith-Waterman score: 164; 23.9% identity (48.3% similar) in 180 aa overlap (14-189:362-524)

                                10        20        30        40   
pF1KB4                  MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVH
                                     : .:    .:.  .  . ::.: :: ..::
XP_011 STEKDSDLDCPSPFSEKLPPISPVSTSGDVCRICHCEGDDE--SPLITPCHCTGSLHFVH
             340       350       360       370         380         

            50        60        70        80          90        100
pF1KB4 QACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYV--LDLADRLISKA-CPFA
       :::::.:.      .:.    :  :. :. :.  :: :.     :....    :  :  .
XP_011 QACLQQWI------KSSDTRCCELCKYEF-IMETKLKPLRKWEKLQMTSSERRKIMCSVT
     390             400       410        420       430       440  

              110       120        130       140       150         
pF1KB4 AAGIMVGSIYWTAVTYGAVTVMQVV-GHKEGLDVMERADPLFLLIGLPTIPVMLILGKMI
          : .  . :.  .    :. ..  :.  :  ..:   :..  . . .:     :  : 
XP_011 FHVIAITCVVWSLYVLIDRTAEEIKQGQATG--ILEW--PFWTKLVVVAIGFTGGLLFMY
            450       460       470           480       490        

     160       170       180       190       200       210         
pF1KB4 RWEDYVLRLWRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTI
             ..::..    :.  : ..   .::                              
XP_011 VQCKVYVQLWKR----LKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENKHGYGICHSD
      500       510           520       530       540       550    

>>XP_005271861 (OMIM: 613335) PREDICTED: E3 ubiquitin-pr  (573 aa)
 initn: 120 init1: 120 opt: 161  Z-score: 193.9  bits: 44.7 E(85289): 0.00046
Smith-Waterman score: 164; 23.9% identity (48.3% similar) in 180 aa overlap (14-189:362-524)

                                10        20        30        40   
pF1KB4                  MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVH
                                     : .:    .:.  .  . ::.: :: ..::
XP_005 STEKDSDLDCPSPFSEKLPPISPVSTSGDVCRICHCEGDDE--SPLITPCHCTGSLHFVH
             340       350       360       370         380         

            50        60        70        80          90        100
pF1KB4 QACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYV--LDLADRLISKA-CPFA
       :::::.:.      .:.    :  :. :. :.  :: :.     :....    :  :  .
XP_005 QACLQQWI------KSSDTRCCELCKYEF-IMETKLKPLRKWEKLQMTSSERRKIMCSVT
     390             400       410        420       430       440  

              110       120        130       140       150         
pF1KB4 AAGIMVGSIYWTAVTYGAVTVMQVV-GHKEGLDVMERADPLFLLIGLPTIPVMLILGKMI
          : .  . :.  .    :. ..  :.  :  ..:   :..  . . .:     :  : 
XP_005 FHVIAITCVVWSLYVLIDRTAEEIKQGQATG--ILEW--PFWTKLVVVAIGFTGGLLFMY
            450       460       470           480       490        

     160       170       180       190       200       210         
pF1KB4 RWEDYVLRLWRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTI
             ..::..    :.  : ..   .::                              
XP_005 VQCKVYVQLWKR----LKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENKHGYGICHSD
      500       510           520       530       540       550    




278 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 05:57:07 2016 done: Sat Nov  5 05:57:08 2016
 Total Scan time:  6.820 Total Display time:  0.010

Function used was FASTA [36.3.4 Apr, 2011]
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