Result of FASTA (omim) for pF1KB4086
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB4086, 520 aa
  1>>>pF1KB4086 520 - 520 aa - 520 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.5039+/-0.00044; mu= 17.1634+/- 0.027
 mean_var=65.6040+/-13.240, 0's: 0 Z-trim(109.8): 20  B-trim: 0 in 0/53
 Lambda= 0.158347
 statistics sampled from 18051 (18070) to 18051 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.575), E-opt: 0.2 (0.212), width:  16
 Scan time:  9.210

The best scores are:                                      opt bits E(85289)
NP_001091742 (OMIM: 142940) hydroxymethylglutaryl- ( 520) 3456 798.8       0
NP_002121 (OMIM: 142940) hydroxymethylglutaryl-CoA ( 520) 3456 798.8       0
NP_001311148 (OMIM: 142940) hydroxymethylglutaryl- ( 520) 3456 798.8       0
NP_001311149 (OMIM: 142940) hydroxymethylglutaryl- ( 520) 3456 798.8       0
NP_001317592 (OMIM: 142940) hydroxymethylglutaryl- ( 520) 3456 798.8       0
NP_005509 (OMIM: 600234,605911) hydroxymethylgluta ( 508) 2218 516.0  1e-145
NP_001311151 (OMIM: 142940) hydroxymethylglutaryl- ( 478) 2185 508.5 1.8e-143
NP_001311153 (OMIM: 142940) hydroxymethylglutaryl- ( 478) 2185 508.5 1.8e-143
NP_001311152 (OMIM: 142940) hydroxymethylglutaryl- ( 478) 2185 508.5 1.8e-143
XP_011512338 (OMIM: 142940) PREDICTED: hydroxymeth ( 323) 2142 498.6 1.2e-140
NP_001159579 (OMIM: 600234,605911) hydroxymethylgl ( 466) 1233 291.0 5.2e-78
XP_011539615 (OMIM: 600234,605911) PREDICTED: hydr ( 453)  985 234.3 5.8e-61


>>NP_001091742 (OMIM: 142940) hydroxymethylglutaryl-CoA   (520 aa)
 initn: 3456 init1: 3456 opt: 3456  Z-score: 4265.3  bits: 798.8 E(85289):    0
Smith-Waterman score: 3456; 100.0% identity (100.0% similar) in 520 aa overlap (1-520:1-520)

               10        20        30        40        50        60
pF1KB4 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
              430       440       450       460       470       480

              490       500       510       520
pF1KB4 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
       ::::::::::::::::::::::::::::::::::::::::
NP_001 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
              490       500       510       520

>>NP_002121 (OMIM: 142940) hydroxymethylglutaryl-CoA syn  (520 aa)
 initn: 3456 init1: 3456 opt: 3456  Z-score: 4265.3  bits: 798.8 E(85289):    0
Smith-Waterman score: 3456; 100.0% identity (100.0% similar) in 520 aa overlap (1-520:1-520)

               10        20        30        40        50        60
pF1KB4 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
              430       440       450       460       470       480

              490       500       510       520
pF1KB4 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
       ::::::::::::::::::::::::::::::::::::::::
NP_002 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
              490       500       510       520

>>NP_001311148 (OMIM: 142940) hydroxymethylglutaryl-CoA   (520 aa)
 initn: 3456 init1: 3456 opt: 3456  Z-score: 4265.3  bits: 798.8 E(85289):    0
Smith-Waterman score: 3456; 100.0% identity (100.0% similar) in 520 aa overlap (1-520:1-520)

               10        20        30        40        50        60
pF1KB4 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
              430       440       450       460       470       480

              490       500       510       520
pF1KB4 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
       ::::::::::::::::::::::::::::::::::::::::
NP_001 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
              490       500       510       520

>>NP_001311149 (OMIM: 142940) hydroxymethylglutaryl-CoA   (520 aa)
 initn: 3456 init1: 3456 opt: 3456  Z-score: 4265.3  bits: 798.8 E(85289):    0
Smith-Waterman score: 3456; 100.0% identity (100.0% similar) in 520 aa overlap (1-520:1-520)

               10        20        30        40        50        60
pF1KB4 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
              430       440       450       460       470       480

              490       500       510       520
pF1KB4 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
       ::::::::::::::::::::::::::::::::::::::::
NP_001 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
              490       500       510       520

>>NP_001317592 (OMIM: 142940) hydroxymethylglutaryl-CoA   (520 aa)
 initn: 3456 init1: 3456 opt: 3456  Z-score: 4265.3  bits: 798.8 E(85289):    0
Smith-Waterman score: 3456; 100.0% identity (100.0% similar) in 520 aa overlap (1-520:1-520)

               10        20        30        40        50        60
pF1KB4 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
              430       440       450       460       470       480

              490       500       510       520
pF1KB4 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
       ::::::::::::::::::::::::::::::::::::::::
NP_001 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
              490       500       510       520

>>NP_005509 (OMIM: 600234,605911) hydroxymethylglutaryl-  (508 aa)
 initn: 2218 init1: 2218 opt: 2218  Z-score: 2737.0  bits: 516.0 E(85289): 1e-145
Smith-Waterman score: 2218; 67.5% identity (89.7% similar) in 467 aa overlap (4-470:41-507)

                                          10        20        30   
pF1KB4                            MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQ
                                     ..::     :::::::.:::.:::.:::::
NP_005 ILQLTRAVQETSLTPARLLPVAHQRFSTASAVPLAKTDTWPKDVGILALEVYFPAQYVDQ
               20        30        40        50        60        70

            40        50        60        70        80        90   
pF1KB4 AELEKYDGVDAGKYTIGLGQAKMGFCTDREDINSLCMTVVQNLMERNNLSYDCIGRLEVG
       ..::::..:.:::::.::::..::::. .:::::::.:::: :::: .: .: .::::::
NP_005 TDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERIQLPWDSVGRLEVG
               80        90       100       110       120       130

           100       110       120       130       140       150   
pF1KB4 TETIIDKSKSVKTNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWIESSSWDGRYA
       :::::::::.::: ::.::..::::::::::::::::::::..:::.::.::::::::::
NP_005 TETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSSWDGRYA
              140       150       160       170       180       190

           160       170       180       190       200       210   
pF1KB4 LVVAGDIAVYATGNARPTGGVGAVALLIGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEY
       .:: :::::: .::::::::.::::.::::.::: .:::::::::...::::::.. :::
NP_005 MVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLALERGLRGTHMENVYDFYKPNLASEY
              200       210       220       230       240       250

           220       230       240       250       260       270   
pF1KB4 PIVDGKLSIQCYLSALDRCYSVYCKKIHAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQK
       ::::::::::::: ::::::. : :::. ::.. :.:. :::.:. .::::.:.::.:::
NP_005 PIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFTLDDLQYMIFHTPFCKMVQK
              260       270       280       290       300       310

           280       290       300       310       320       330   
pF1KB4 SLARMLLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTKA
       ::::...::::. ..  ..:.:.:::::: .:::::: ..:..::..:::...:..::::
NP_005 SLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKASQDMFDKKTKA
              320       330       340       350       360       370

           340       350       360       370       380       390   
pF1KB4 SLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQDAT
       :: .:..::::::::.:: :::.:...: :.:::.:::.:::::::::...:..:.:::.
NP_005 SLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSQDAA
              380       390       400       410       420       430

           400       410       420       430       440       450   
pF1KB4 PGSALDKITASLCDLKSRLDSRTGVAPDVFAENMKLREDTHHLVNYIPQGSIDSLFEGTW
       ::: :::...:  :: .:: ::  :.:. :.: :. ::. .: ::. : :. .::: :::
NP_005 PGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQREQFYHKVNFSPPGDTNSLFPGTW
              440       450       460       470       480       490

           460       470       480       490       500       510   
pF1KB4 YLVRVDEKHRRTYARRPTPNDDTLDEGVGLVHSNIATEHIPSPAKKVPRLPATAAEPEAA
       :: ::::.::: :::::                                           
NP_005 YLERVDEQHRRKYARRPV                                          
              500                                                  

>>NP_001311151 (OMIM: 142940) hydroxymethylglutaryl-CoA   (478 aa)
 initn: 2185 init1: 2185 opt: 2185  Z-score: 2696.6  bits: 508.5 E(85289): 1.8e-143
Smith-Waterman score: 3093; 91.9% identity (91.9% similar) in 520 aa overlap (1-520:1-478)

               10        20        30        40        50        60
pF1KB4 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
       ::::::::::::::::::::::::::::::                              
NP_001 EGIDTTNACYGGTAAVFNAVNWIESSSWDG------------------------------
              130       140       150                              

              190       200       210       220       230       240
pF1KB4 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
                   ::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ------------LRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
                          160       170       180       190        

              250       260       270       280       290       300
pF1KB4 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
      200       210       220       230       240       250        

              310       320       330       340       350       360
pF1KB4 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
      260       270       280       290       300       310        

              370       380       390       400       410       420
pF1KB4 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
      320       330       340       350       360       370        

              430       440       450       460       470       480
pF1KB4 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
      380       390       400       410       420       430        

              490       500       510       520
pF1KB4 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
       ::::::::::::::::::::::::::::::::::::::::
NP_001 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
      440       450       460       470        

>>NP_001311153 (OMIM: 142940) hydroxymethylglutaryl-CoA   (478 aa)
 initn: 2185 init1: 2185 opt: 2185  Z-score: 2696.6  bits: 508.5 E(85289): 1.8e-143
Smith-Waterman score: 3093; 91.9% identity (91.9% similar) in 520 aa overlap (1-520:1-478)

               10        20        30        40        50        60
pF1KB4 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
       ::::::::::::::::::::::::::::::                              
NP_001 EGIDTTNACYGGTAAVFNAVNWIESSSWDG------------------------------
              130       140       150                              

              190       200       210       220       230       240
pF1KB4 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
                   ::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ------------LRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
                          160       170       180       190        

              250       260       270       280       290       300
pF1KB4 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
      200       210       220       230       240       250        

              310       320       330       340       350       360
pF1KB4 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
      260       270       280       290       300       310        

              370       380       390       400       410       420
pF1KB4 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
      320       330       340       350       360       370        

              430       440       450       460       470       480
pF1KB4 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
      380       390       400       410       420       430        

              490       500       510       520
pF1KB4 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
       ::::::::::::::::::::::::::::::::::::::::
NP_001 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
      440       450       460       470        

>>NP_001311152 (OMIM: 142940) hydroxymethylglutaryl-CoA   (478 aa)
 initn: 2185 init1: 2185 opt: 2185  Z-score: 2696.6  bits: 508.5 E(85289): 1.8e-143
Smith-Waterman score: 3093; 91.9% identity (91.9% similar) in 520 aa overlap (1-520:1-478)

               10        20        30        40        50        60
pF1KB4 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
       ::::::::::::::::::::::::::::::                              
NP_001 EGIDTTNACYGGTAAVFNAVNWIESSSWDG------------------------------
              130       140       150                              

              190       200       210       220       230       240
pF1KB4 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
                   ::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ------------LRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
                          160       170       180       190        

              250       260       270       280       290       300
pF1KB4 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
      200       210       220       230       240       250        

              310       320       330       340       350       360
pF1KB4 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
      260       270       280       290       300       310        

              370       380       390       400       410       420
pF1KB4 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
      320       330       340       350       360       370        

              430       440       450       460       470       480
pF1KB4 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
      380       390       400       410       420       430        

              490       500       510       520
pF1KB4 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
       ::::::::::::::::::::::::::::::::::::::::
NP_001 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
      440       450       460       470        

>>XP_011512338 (OMIM: 142940) PREDICTED: hydroxymethylgl  (323 aa)
 initn: 2142 init1: 2142 opt: 2142  Z-score: 2646.2  bits: 498.6 E(85289): 1.2e-140
Smith-Waterman score: 2142; 100.0% identity (100.0% similar) in 323 aa overlap (198-520:1-323)

       170       180       190       200       210       220       
pF1KB4 ARPTGGVGAVALLIGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLS
                                     ::::::::::::::::::::::::::::::
XP_011                               MQHAYDFYKPDMLSEYPIVDGKLSIQCYLS
                                             10        20        30

       230       240       250       260       270       280       
pF1KB4 ALDRCYSVYCKKIHAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALDRCYSVYCKKIHAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQ
               40        50        60        70        80        90

       290       300       310       320       330       340       
pF1KB4 NRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTS
              100       110       120       130       140       150

       350       360       370       380       390       400       
pF1KB4 SVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCD
              160       170       180       190       200       210

       410       420       430       440       450       460       
pF1KB4 LKSRLDSRTGVAPDVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKSRLDSRTGVAPDVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYA
              220       230       240       250       260       270

       470       480       490       500       510       520
pF1KB4 RRPTPNDDTLDEGVGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
       :::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRPTPNDDTLDEGVGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
              280       290       300       310       320   




520 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 05:36:13 2016 done: Sat Nov  5 05:36:14 2016
 Total Scan time:  9.210 Total Display time:  0.100

Function used was FASTA [36.3.4 Apr, 2011]
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