FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4038, 363 aa 1>>>pF1KB4038 363 - 363 aa - 363 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.4465+/-0.000302; mu= 9.2869+/- 0.019 mean_var=164.5285+/-33.221, 0's: 0 Z-trim(122.5): 91 B-trim: 0 in 0/54 Lambda= 0.099989 statistics sampled from 40585 (40690) to 40585 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.798), E-opt: 0.2 (0.477), width: 16 Scan time: 9.460 The best scores are: opt bits E(85289) NP_001017368 (OMIM: 609735) E3 ubiquitin-protein l ( 363) 2533 376.6 4.7e-104 NP_079402 (OMIM: 608299) E3 ubiquitin-protein liga ( 372) 981 152.8 1.2e-36 NP_919247 (OMIM: 608299) E3 ubiquitin-protein liga ( 373) 981 152.8 1.2e-36 NP_001243787 (OMIM: 608299) E3 ubiquitin-protein l ( 180) 607 98.5 1.2e-20 NP_001243095 (OMIM: 601712) baculoviral IAP repeat ( 569) 205 41.0 0.0082 NP_001243092 (OMIM: 601712) baculoviral IAP repeat ( 618) 205 41.0 0.0087 NP_001157 (OMIM: 601712) baculoviral IAP repeat-co ( 618) 205 41.0 0.0087 >>NP_001017368 (OMIM: 609735) E3 ubiquitin-protein ligas (363 aa) initn: 2533 init1: 2533 opt: 2533 Z-score: 1989.1 bits: 376.6 E(85289): 4.7e-104 Smith-Waterman score: 2533; 100.0% identity (100.0% similar) in 363 aa overlap (1-363:1-363) 10 20 30 40 50 60 pF1KB4 MWATCCNWFCLDGQPEEVPPPQGARMQAYSNPGYSSFPSPTGLEPSCKSCGAHFANTARK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MWATCCNWFCLDGQPEEVPPPQGARMQAYSNPGYSSFPSPTGLEPSCKSCGAHFANTARK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 QTCLDCKKNFCMTCSSQVGNGPRLCLLCQRFRATAFQREELMKMKVKDLRDYLSLHDIST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QTCLDCKKNFCMTCSSQVGNGPRLCLLCQRFRATAFQREELMKMKVKDLRDYLSLHDIST 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 EMCREKEELVLLVLGQQPVISQEDRTRASTLSPDFPEQQAFLTQPHSSMVPPTSPNLPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EMCREKEELVLLVLGQQPVISQEDRTRASTLSPDFPEQQAFLTQPHSSMVPPTSPNLPSS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 SAQATSVPPAQVQENQQANGHVSQDQEEPVYLESVARVPAEDETQSIDSEDSFVPGRRAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAQATSVPPAQVQENQQANGHVSQDQEEPVYLESVARVPAEDETQSIDSEDSFVPGRRAS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 LSDLTDLEDIEGLTVRQLKEILARNFVNYKGCCEKWELMERVTRLYKDQKGLQHLVSGAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSDLTDLEDIEGLTVRQLKEILARNFVNYKGCCEKWELMERVTRLYKDQKGLQHLVSGAE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 DQNGGAVPSGLEENLCKICMDSPIDCVLLECGHMVTCTKCGKRMNECPICRQYVIRAVHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQNGGAVPSGLEENLCKICMDSPIDCVLLECGHMVTCTKCGKRMNECPICRQYVIRAVHV 310 320 330 340 350 360 pF1KB4 FRS ::: NP_001 FRS >>NP_079402 (OMIM: 608299) E3 ubiquitin-protein ligase R (372 aa) initn: 939 init1: 432 opt: 981 Z-score: 779.0 bits: 152.8 E(85289): 1.2e-36 Smith-Waterman score: 981; 44.2% identity (69.1% similar) in 382 aa overlap (1-363:8-372) 10 20 30 40 pF1KB4 MWATCCNWF-------CLDGQPEEVPPPQGARMQAYSNPGYSSFPSPTGLE-P :::.::. . . :: : .. :: .:..: :.. : : NP_079 MKAGATSMWASCCGLLNEVMGTGAVRGQQSAFAGATGP-FRFTPNPEFSTYP-PAATEGP 10 20 30 40 50 50 60 70 80 90 100 pF1KB4 S--CKSCGAHFANTARKQTCLDCKKNFCMTCSSQVGNGPRLCLLCQRFRATAFQREELMK . ::.:: :. .:..: ::::.:: .:: . .. : : :. .. ::::: .::. NP_079 NIVCKACGLSFSVFRKKHVCCDCKKDFCSVCSV-LQENLRRCSTCHLLQETAFQRPQLMR 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB4 MKVKDLRDYLSLHDISTEMCREKEELVLLVLGQQPVISQEDRTRASTLSPDFPEQQAFLT .::::::.:: :..: . :::::.:: ::: .. . :..: .:.:. . . ..:.: NP_079 LKVKDLRQYLILRNIPIDTCREKEDLVDLVLCHHGLGSEDDMD-TSSLNSSRSQTSSFFT 120 130 140 150 160 170 170 180 190 200 210 pF1KB4 QPHSSMVPPTSPNLPSSSAQ---------ATSVPPAQVQENQQANGHVSQDQEEPVYLES . : :.:. :: : . : ::::: .. ..... .:... .. NP_079 RSFFSNY--TAPSATMSSFQGELMDGDQTSRSGVPAQVQ-SEITSANTEDDDDDDDEDDD 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB4 VARVPAEDETQSIDSEDSFVPGRRASLSDLTDLEDIEGLTVRQLKEILARNFVNYKGCCE . :::.. ....: :::::::..:.:.::..:::::::::::::::.:::: NP_079 DEEENAEDRNPGLSKERV-----RASLSDLSSLDDVEGMSVRQLKEILARNFVNYSGCCE 240 250 260 270 280 280 290 300 310 320 330 pF1KB4 KWELMERVTRLYKDQKGLQHLVSGAEDQNGGAVPSGLEENLCKICMDSPIDCVLLECGHM ::::.:.:.::::... :. : . : . . ...::.::::. ::::::::::: NP_079 KWELVEKVNRLYKENEENQKSY-GERLQ----LQDEEDDSLCRICMDAVIDCVLLECGHM 290 300 310 320 330 340 340 350 360 pF1KB4 VTCTKCGKRMNECPICRQYVIRAVHVFRS ::::::::::.:::::::::.::::::.: NP_079 VTCTKCGKRMSECPICRQYVVRAVHVFKS 350 360 370 >>NP_919247 (OMIM: 608299) E3 ubiquitin-protein ligase R (373 aa) initn: 939 init1: 432 opt: 981 Z-score: 779.0 bits: 152.8 E(85289): 1.2e-36 Smith-Waterman score: 981; 44.2% identity (69.1% similar) in 382 aa overlap (1-363:9-373) 10 20 30 40 pF1KB4 MWATCCNWF-------CLDGQPEEVPPPQGARMQAYSNPGYSSFPSPTGLE- :::.::. . . :: : .. :: .:..: :.. : NP_919 MRKAGATSMWASCCGLLNEVMGTGAVRGQQSAFAGATGP-FRFTPNPEFSTYP-PAATEG 10 20 30 40 50 50 60 70 80 90 100 pF1KB4 PS--CKSCGAHFANTARKQTCLDCKKNFCMTCSSQVGNGPRLCLLCQRFRATAFQREELM :. ::.:: :. .:..: ::::.:: .:: . .. : : :. .. ::::: .:: NP_919 PNIVCKACGLSFSVFRKKHVCCDCKKDFCSVCSV-LQENLRRCSTCHLLQETAFQRPQLM 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB4 KMKVKDLRDYLSLHDISTEMCREKEELVLLVLGQQPVISQEDRTRASTLSPDFPEQQAFL ..::::::.:: :..: . :::::.:: ::: .. . :..: .:.:. . . ..:. NP_919 RLKVKDLRQYLILRNIPIDTCREKEDLVDLVLCHHGLGSEDDMD-TSSLNSSRSQTSSFF 120 130 140 150 160 170 170 180 190 200 210 pF1KB4 TQPHSSMVPPTSPNLPSSSAQ---------ATSVPPAQVQENQQANGHVSQDQEEPVYLE :. : :.:. :: : . : ::::: .. ..... .:... . NP_919 TRSFFSNY--TAPSATMSSFQGELMDGDQTSRSGVPAQVQ-SEITSANTEDDDDDDDEDD 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB4 SVARVPAEDETQSIDSEDSFVPGRRASLSDLTDLEDIEGLTVRQLKEILARNFVNYKGCC . . :::.. ....: :::::::..:.:.::..:::::::::::::::.::: NP_919 DDEEENAEDRNPGLSKERV-----RASLSDLSSLDDVEGMSVRQLKEILARNFVNYSGCC 240 250 260 270 280 280 290 300 310 320 330 pF1KB4 EKWELMERVTRLYKDQKGLQHLVSGAEDQNGGAVPSGLEENLCKICMDSPIDCVLLECGH :::::.:.:.::::... :. : . : . . ...::.::::. :::::::::: NP_919 EKWELVEKVNRLYKENEENQKSY-GERLQ----LQDEEDDSLCRICMDAVIDCVLLECGH 290 300 310 320 330 340 340 350 360 pF1KB4 MVTCTKCGKRMNECPICRQYVIRAVHVFRS :::::::::::.:::::::::.::::::.: NP_919 MVTCTKCGKRMSECPICRQYVVRAVHVFKS 350 360 370 >>NP_001243787 (OMIM: 608299) E3 ubiquitin-protein ligas (180 aa) initn: 636 init1: 339 opt: 607 Z-score: 491.6 bits: 98.5 E(85289): 1.2e-20 Smith-Waterman score: 621; 54.9% identity (80.6% similar) in 175 aa overlap (189-363:17-180) 160 170 180 190 200 210 pF1KB4 QAFLTQPHSSMVPPTSPNLPSSSAQATSVPPAQVQENQQANGHVSQDQEEPVYLESVARV ::::: .. ..... .:... .. . NP_001 MKGELMDGDQTSRSGVPAQVQ-SEITSANTEDDDDDDDEDDDDEEE 10 20 30 40 220 230 240 250 260 270 pF1KB4 PAEDETQSIDSEDSFVPGRRASLSDLTDLEDIEGLTVRQLKEILARNFVNYKGCCEKWEL :::.. ....: :::::::..:.:.::..:::::::::::::::.:::::::: NP_001 NAEDRNPGLSKERV-----RASLSDLSSLDDVEGMSVRQLKEILARNFVNYSGCCEKWEL 50 60 70 80 90 100 280 290 300 310 320 330 pF1KB4 MERVTRLYKDQKGLQHLVSGAEDQNGGAVPSGLEENLCKICMDSPIDCVLLECGHMVTCT .:.:.::::... :. : . : . . ...::.::::. ::::::::::::::: NP_001 VEKVNRLYKENEENQK-SYGERLQ----LQDEEDDSLCRICMDAVIDCVLLECGHMVTCT 110 120 130 140 150 340 350 360 pF1KB4 KCGKRMNECPICRQYVIRAVHVFRS ::::::.:::::::::.::::::.: NP_001 KCGKRMSECPICRQYVVRAVHVFKS 160 170 180 >>NP_001243095 (OMIM: 601712) baculoviral IAP repeat-con (569 aa) initn: 185 init1: 185 opt: 205 Z-score: 171.5 bits: 41.0 E(85289): 0.0082 Smith-Waterman score: 205; 33.3% identity (62.7% similar) in 102 aa overlap (269-363:475-569) 240 250 260 270 280 290 pF1KB4 ASLSDLTDLEDIEGLTVRQLKEILARNFVNYKGCCEKWELMERVTRLYKD---QKGLQHL .:.: : : . :::. .:..... NP_001 DIIKQKTQIPLQARELIDTILVKGNAAANIFKNC-----LKEIDSTLYKNLFVDKNMKYI 450 460 470 480 490 300 310 320 330 340 350 pF1KB4 VSGAEDQNGGAVPSGL----EENLCKICMDSPIDCVLLECGHMVTCTKCGKRMNECPICR . :: .: .. : :: ::.:::. .. :.. :::.:.: .:. . .::::: NP_001 PT--EDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICR 500 510 520 530 540 550 360 pF1KB4 QYVIRAVHVFRS . .:..: : NP_001 GIIKGTVRTFLS 560 >>NP_001243092 (OMIM: 601712) baculoviral IAP repeat-con (618 aa) initn: 185 init1: 185 opt: 205 Z-score: 171.0 bits: 41.0 E(85289): 0.0087 Smith-Waterman score: 205; 33.3% identity (62.7% similar) in 102 aa overlap (269-363:524-618) 240 250 260 270 280 290 pF1KB4 ASLSDLTDLEDIEGLTVRQLKEILARNFVNYKGCCEKWELMERVTRLYKD---QKGLQHL .:.: : : . :::. .:..... NP_001 DIIKQKTQIPLQARELIDTILVKGNAAANIFKNC-----LKEIDSTLYKNLFVDKNMKYI 500 510 520 530 540 300 310 320 330 340 350 pF1KB4 VSGAEDQNGGAVPSGL----EENLCKICMDSPIDCVLLECGHMVTCTKCGKRMNECPICR . :: .: .. : :: ::.:::. .. :.. :::.:.: .:. . .::::: NP_001 PT--EDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICR 550 560 570 580 590 600 360 pF1KB4 QYVIRAVHVFRS . .:..: : NP_001 GIIKGTVRTFLS 610 >>NP_001157 (OMIM: 601712) baculoviral IAP repeat-contai (618 aa) initn: 185 init1: 185 opt: 205 Z-score: 171.0 bits: 41.0 E(85289): 0.0087 Smith-Waterman score: 205; 33.3% identity (62.7% similar) in 102 aa overlap (269-363:524-618) 240 250 260 270 280 290 pF1KB4 ASLSDLTDLEDIEGLTVRQLKEILARNFVNYKGCCEKWELMERVTRLYKD---QKGLQHL .:.: : : . :::. .:..... NP_001 DIIKQKTQIPLQARELIDTILVKGNAAANIFKNC-----LKEIDSTLYKNLFVDKNMKYI 500 510 520 530 540 300 310 320 330 340 350 pF1KB4 VSGAEDQNGGAVPSGL----EENLCKICMDSPIDCVLLECGHMVTCTKCGKRMNECPICR . :: .: .. : :: ::.:::. .. :.. :::.:.: .:. . .::::: NP_001 PT--EDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICR 550 560 570 580 590 600 360 pF1KB4 QYVIRAVHVFRS . .:..: : NP_001 GIIKGTVRTFLS 610 363 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 05:33:56 2016 done: Sat Nov 5 05:33:57 2016 Total Scan time: 9.460 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]