Result of FASTA (ccds) for
pF1KE0946
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0946, 367 aa
1>>>pF1KE0946 367 - 367 aa - 367 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.9302+/-0.00115; mu= 0.3505+/- 0.068
mean_var=269.0154+/-59.328, 0's: 0 Z-trim(111.7): 625 B-trim: 307 in 1/53
Lambda= 0.078196
statistics sampled from 11842 (12590) to 11842 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.741), E-opt: 0.2 (0.387), width: 16
Scan time: 3.000
The best scores are: opt bits E(32554)
CCDS4112.1 TSSK1B gene_id:83942|Hs108|chr5 ( 367) 2475 292.5 4e-79
CCDS13755.1 TSSK2 gene_id:23617|Hs108|chr22 ( 358) 1597 193.4 2.6e-49
CCDS362.1 TSSK3 gene_id:81629|Hs108|chr1 ( 268) 866 110.8 1.4e-24
CCDS12403.1 TSSK6 gene_id:83983|Hs108|chr19 ( 273) 817 105.3 6.6e-23
CCDS60974.1 SIK3 gene_id:23387|Hs108|chr11 (1261) 702 93.0 1.5e-18
CCDS82645.1 LOC102724428 gene_id:102724428|Hs108|c ( 783) 696 92.1 1.8e-18
CCDS33575.1 SIK1 gene_id:150094|Hs108|chr21 ( 783) 696 92.1 1.8e-18
CCDS8379.2 SIK3 gene_id:23387|Hs108|chr11 (1321) 682 90.7 7.6e-18
CCDS8347.1 SIK2 gene_id:23235|Hs108|chr11 ( 926) 662 88.3 2.8e-17
CCDS73034.1 MARK1 gene_id:4139|Hs108|chr1 ( 780) 648 86.7 7.5e-17
CCDS31029.2 MARK1 gene_id:4139|Hs108|chr1 ( 795) 648 86.7 7.6e-17
CCDS73033.1 MARK1 gene_id:4139|Hs108|chr1 ( 796) 648 86.7 7.6e-17
CCDS53651.1 MARK2 gene_id:2011|Hs108|chr11 ( 709) 645 86.3 8.9e-17
CCDS55947.1 MARK3 gene_id:4140|Hs108|chr14 ( 713) 645 86.3 8.9e-17
CCDS53650.1 MARK2 gene_id:2011|Hs108|chr11 ( 719) 645 86.3 8.9e-17
CCDS8051.2 MARK2 gene_id:2011|Hs108|chr11 ( 724) 645 86.3 9e-17
CCDS41993.1 MARK3 gene_id:4140|Hs108|chr14 ( 729) 645 86.3 9e-17
CCDS45166.1 MARK3 gene_id:4140|Hs108|chr14 ( 744) 645 86.3 9.2e-17
CCDS41665.1 MARK2 gene_id:2011|Hs108|chr11 ( 745) 645 86.3 9.2e-17
CCDS45165.1 MARK3 gene_id:4140|Hs108|chr14 ( 753) 645 86.3 9.2e-17
CCDS53649.1 MARK2 gene_id:2011|Hs108|chr11 ( 788) 645 86.4 9.5e-17
CCDS12658.1 MARK4 gene_id:57787|Hs108|chr19 ( 688) 631 84.7 2.6e-16
CCDS56097.1 MARK4 gene_id:57787|Hs108|chr19 ( 752) 631 84.8 2.8e-16
CCDS43075.1 SNRK gene_id:54861|Hs108|chr3 ( 765) 608 82.2 1.7e-15
CCDS31892.1 NUAK1 gene_id:9891|Hs108|chr12 ( 661) 604 81.6 2.1e-15
CCDS1453.2 NUAK2 gene_id:81788|Hs108|chr1 ( 672) 592 80.3 5.4e-15
CCDS3932.2 PRKAA1 gene_id:5562|Hs108|chr5 ( 559) 579 78.8 1.3e-14
CCDS605.1 PRKAA2 gene_id:5563|Hs108|chr1 ( 552) 574 78.2 1.9e-14
CCDS13610.1 HUNK gene_id:30811|Hs108|chr21 ( 714) 575 78.4 2.1e-14
CCDS41590.1 BRSK2 gene_id:9024|Hs108|chr11 ( 668) 565 77.3 4.4e-14
CCDS58106.1 BRSK2 gene_id:9024|Hs108|chr11 ( 674) 565 77.3 4.5e-14
CCDS58107.1 BRSK2 gene_id:9024|Hs108|chr11 ( 736) 565 77.3 4.7e-14
CCDS12921.1 BRSK1 gene_id:84446|Hs108|chr19 ( 778) 556 76.3 1e-13
CCDS3943.1 NIM1K gene_id:167359|Hs108|chr5 ( 436) 549 75.3 1.1e-13
CCDS58108.1 BRSK2 gene_id:9024|Hs108|chr11 ( 766) 552 75.8 1.3e-13
CCDS59123.1 MELK gene_id:9833|Hs108|chr9 ( 610) 543 74.7 2.3e-13
CCDS6606.1 MELK gene_id:9833|Hs108|chr9 ( 651) 543 74.8 2.4e-13
CCDS2582.1 CAMK1 gene_id:8536|Hs108|chr3 ( 370) 532 73.3 3.9e-13
CCDS60696.1 BRSK2 gene_id:9024|Hs108|chr11 ( 614) 514 71.5 2.3e-12
CCDS1486.1 CAMK1G gene_id:57172|Hs108|chr1 ( 476) 491 68.8 1.1e-11
CCDS13843.1 CHEK2 gene_id:11200|Hs108|chr22 ( 543) 491 68.8 1.2e-11
CCDS33629.1 CHEK2 gene_id:11200|Hs108|chr22 ( 586) 491 68.8 1.3e-11
CCDS59126.1 MELK gene_id:9833|Hs108|chr9 ( 619) 490 68.8 1.5e-11
CCDS65789.1 MARK1 gene_id:4139|Hs108|chr1 ( 758) 475 67.2 5.5e-11
CCDS73254.1 STK33 gene_id:65975|Hs108|chr11 ( 473) 468 66.2 6.9e-11
CCDS7092.1 CAMK1D gene_id:57118|Hs108|chr10 ( 357) 465 65.7 7.1e-11
CCDS7789.1 STK33 gene_id:65975|Hs108|chr11 ( 514) 468 66.2 7.3e-11
CCDS7091.1 CAMK1D gene_id:57118|Hs108|chr10 ( 385) 465 65.7 7.5e-11
CCDS10616.1 PLK1 gene_id:5347|Hs108|chr16 ( 603) 467 66.2 8.8e-11
>>CCDS4112.1 TSSK1B gene_id:83942|Hs108|chr5 (367 aa)
initn: 2475 init1: 2475 opt: 2475 Z-score: 1534.0 bits: 292.5 E(32554): 4e-79
Smith-Waterman score: 2475; 100.0% identity (100.0% similar) in 367 aa overlap (1-367:1-367)
10 20 30 40 50 60
pF1KE0 MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS41 MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPRE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 IEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS41 IEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 SLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS41 SLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 YAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS41 YAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 LTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKARGSPSVAINKEGESSRGTEPLWTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS41 LTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKARGSPSVAINKEGESSRGTEPLWTP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 EPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFPSKPSTMETEEGPPQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS41 EPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFPSKPSTMETEEGPPQQ
310 320 330 340 350 360
pF1KE0 PPETRAQ
:::::::
CCDS41 PPETRAQ
>>CCDS13755.1 TSSK2 gene_id:23617|Hs108|chr22 (358 aa)
initn: 1602 init1: 1566 opt: 1597 Z-score: 998.9 bits: 193.4 E(32554): 2.6e-49
Smith-Waterman score: 1597; 71.8% identity (89.4% similar) in 330 aa overlap (1-327:1-330)
10 20 30 40 50 60
pF1KE0 MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPRE
::::.::...::..:::::.:::::::::::::::::::.:::::::.:.::.:.:::::
CCDS13 MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPRE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 IEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQL
..::: .:: :::::::::::: :..::.:::.:::::::.:: .:::::: ::: :.::
CCDS13 MDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 SLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPA
: :.:::::::.:::::::.:::::::::::::::.::::::::..::. :::::::: :
CCDS13 SSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 YAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKH
::::::::.::::::::::::::::::::::::::::::.:.:::::::::::.:::::.
CCDS13 YAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKN
190 200 210 220 230 240
250 260 270 280 290
pF1KE0 LTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQP-KARGSPSVAINKEGESSRGTEPLWT
:: :::::::.::::::..:::::::::: :.:: : ... :.....:::.. .:
CCDS13 LTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKPKATSSASFKREGEGKYRAECKLD
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE0 PEPG--SDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFPSKPSTMETEEGP
. : :.. :: . . . . ::..
CCDS13 TKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAETSRAKDHHISGAEVGKAST
310 320 330 340 350
>>CCDS362.1 TSSK3 gene_id:81629|Hs108|chr1 (268 aa)
initn: 825 init1: 447 opt: 866 Z-score: 554.7 bits: 110.8 E(32554): 1.4e-24
Smith-Waterman score: 866; 47.4% identity (76.5% similar) in 272 aa overlap (1-272:1-265)
10 20 30 40 50 60
pF1KE0 MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPRE
:.: : :: :: ..:::.:.::: :.:.. . .::::.::. .: .:...:::::
CCDS36 MED--FLLSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRE
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 IEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQL
..:. :.: .::..::..:.. ::. .::::: ::... . . : : :..:. :.:.
CCDS36 LQIVRTLDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQM
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE0 SLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPA
::.::: :.::::::.: :: . ::.::.::.:.: . : : ::.::::: :
CCDS36 VEAIRYCHGCGVAHRDLKCENALL-QGFNLKLTDFGFAK--VLPKSHR-ELSQTFCGSTA
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE0 YAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKH
:::::::::::.. : :.::.::.::.:.:.:.:.::..: ::: :... :.::
CCDS36 YAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLW-QQQKGVSFPTHLS
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE0 LTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKARGSPSVAINKEGESSRGTEPLWTP
....:.::. ..:.::. : :.:. : :.
CCDS36 ISADCQDLLKRLLEPDMILRPSIEEVSWHPWLAST
240 250 260
310 320 330 340 350 360
pF1KE0 EPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFPSKPSTMETEEGPPQQ
>>CCDS12403.1 TSSK6 gene_id:83983|Hs108|chr19 (273 aa)
initn: 771 init1: 302 opt: 817 Z-score: 524.8 bits: 105.3 E(32554): 6.6e-23
Smith-Waterman score: 817; 46.2% identity (72.0% similar) in 279 aa overlap (1-278:1-273)
10 20 30 40 50 60
pF1KE0 MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPRE
:. .:.. :: :: ..:::::.::: : :.. : .::::..::..:: ::..::::::
CCDS12 MSGDKLLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 IEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQL
. :: . : :....:..:. .::.::::: :. :::. .. : . .:: : :.
CCDS12 LSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAAT-DLLQAVQRNGRIPGVQARDLFAQI
70 80 90 100 110
130 140 150 160 170
pF1KE0 SLAIKYCHDLDVVHRDLKCDNLLLDKDFN-IKLSDFSFSKRCLRDDSGRMALSKTFCGSP
. :..: :: .:::::::.:.::. : .::.::.:. :. : :: :.:::
CCDS12 AGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFG----RQAHGYPDLSTTYCGSA
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE0 AYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSK
:::.:::: ::::.:: ::.::.::.::.:: : ::.:::.: . : ::. : .:..
CCDS12 AYASPEVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRG-VLYPEGL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 HLTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKARGSPSVAINKEGESSRGTEPLWT
.:. .:: :: ..:: . . : .. .::.. :
CCDS12 ELSERCKALIAELLQFSPSARPSAGQVARNCWLRAGDSG
240 250 260 270
300 310 320 330 340 350
pF1KE0 PEPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFPSKPSTMETEEGPPQ
>>CCDS60974.1 SIK3 gene_id:23387|Hs108|chr11 (1261 aa)
initn: 657 init1: 245 opt: 702 Z-score: 446.3 bits: 93.0 E(32554): 1.5e-18
Smith-Waterman score: 707; 38.2% identity (65.4% similar) in 356 aa overlap (9-340:62-404)
10 20 30
pF1KE0 MDDAAVLKRRGYL-LGINLGEGSYAKVKSAYSERLKFN
: :: . ..:.:..: :: : : .
CCDS60 PGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAK
40 50 60 70 80 90
40 50 60 70 80 90
pF1KE0 VAIKIIDRKKAPADFLEKFLPREIEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGD
:::::::. . . :.:.. ::..:. :: : ::. :...:: . .:.: : : :.
CCDS60 VAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPHIIRLYQVMETER-MIYLVTEYASGGE
100 110 120 130 140
100 110 120 130 140 150
pF1KE0 LLELIKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSF
... . ..: . : :::.::.:. :. .:: ..:::::: .::::: ..:::..::.:
CCDS60 IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF
150 160 170 180 190 200
160 170 180 190 200 210
pF1KE0 SKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIPYQ-PKVYDIWSLGVILYIMVCGSMPY
:. :. : ::.:::: :::::...: :. ::: :::::::.::..:::..:.
CCDS60 SNLFT---PGQ--LLKTWCGSPPYAAPELFEGKEYDGPKV-DIWSLGVVLYVLVCGALPF
210 220 230 240 250 260
220 230 240 250 260 270
pF1KE0 DDSNIKKM-LRIQK-EHRVNFPRSKHLTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQP
: :..... :. . . :. : .. ::. :: ::: : :.:: ...: .: ::.
CCDS60 DGSTLQNLRARVLSGKFRIPF----FMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMK-
270 280 290 300 310
280 290 300 310 320
pF1KE0 KARGSPS----VAINKEGESSRGTEPL------WTPEPGSDKKSATKLEPEGEAQ----P
. ..:. .: .. . : ..:: . : ::... . : : :. :
CCDS60 LGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQAEQAGTAMNISVP
320 330 340 350 360 370
330 340 350 360
pF1KE0 QAQ---PETK---PEGTAMQMSRQSEILGFPSKPSTMETEEGPPQQPPETRAQ
:.: ::.. :.:: : ..:
CCDS60 QVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKL
380 390 400 410 420 430
>>CCDS82645.1 LOC102724428 gene_id:102724428|Hs108|chr21 (783 aa)
initn: 730 init1: 263 opt: 696 Z-score: 445.3 bits: 92.1 E(32554): 1.8e-18
Smith-Waterman score: 696; 43.5% identity (68.8% similar) in 276 aa overlap (18-291:33-299)
10 20 30 40
pF1KE0 MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKK
::.:..: :: : . : .:::::::. .
CCDS82 IMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTR
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE0 APADFLEKFLPREIEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGA
.. :::. ::.... .::: ::: :...::. .::: :.: .:.... . . :
CCDS82 LDSSNLEKIY-REVQLMKLLNHPHIIKLYQVMETKD-MLYIVTEFAKNGEMFDYLTSNGH
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE0 LHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSG
: :.:::::: :. :..:::: .:::::: .::::: ...:::.::.:.. ::
CCDS82 LSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGN---FYKSG
130 140 150 160 170
170 180 190 200 210 220
pF1KE0 RMALSKTFCGSPAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRI
. :: :.:::: ::::::..: :. :::::::.::..::::.:.: :. . .
CCDS82 E-PLS-TWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQR
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE0 QKEHRVNFPRSKHLTGECKDLIYHMLQPDVNRRLHIDEILSHCWM--QPKARGSPSVAIN
: : .: .. .:..:: .:: : ::. : .: .: :: .: : :..
CCDS82 VLEGRFRIPF--FMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFS
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE0 KEGESSRGTEPLWTPEPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFP
.. .:
CCDS82 AHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQC
300 310 320 330 340 350
>>CCDS33575.1 SIK1 gene_id:150094|Hs108|chr21 (783 aa)
initn: 730 init1: 263 opt: 696 Z-score: 445.3 bits: 92.1 E(32554): 1.8e-18
Smith-Waterman score: 696; 43.5% identity (68.8% similar) in 276 aa overlap (18-291:33-299)
10 20 30 40
pF1KE0 MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKK
::.:..: :: : . : .:::::::. .
CCDS33 IMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTR
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE0 APADFLEKFLPREIEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGA
.. :::. ::.... .::: ::: :...::. .::: :.: .:.... . . :
CCDS33 LDSSNLEKIY-REVQLMKLLNHPHIIKLYQVMETKD-MLYIVTEFAKNGEMFDYLTSNGH
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE0 LHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSG
: :.:::::: :. :..:::: .:::::: .::::: ...:::.::.:.. ::
CCDS33 LSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGN---FYKSG
130 140 150 160 170
170 180 190 200 210 220
pF1KE0 RMALSKTFCGSPAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRI
. :: :.:::: ::::::..: :. :::::::.::..::::.:.: :. . .
CCDS33 E-PLS-TWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQR
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE0 QKEHRVNFPRSKHLTGECKDLIYHMLQPDVNRRLHIDEILSHCWM--QPKARGSPSVAIN
: : .: .. .:..:: .:: : ::. : .: .: :: .: : :..
CCDS33 VLEGRFRIPF--FMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFS
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE0 KEGESSRGTEPLWTPEPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFP
.. .:
CCDS33 AHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQC
300 310 320 330 340 350
>>CCDS8379.2 SIK3 gene_id:23387|Hs108|chr11 (1321 aa)
initn: 682 init1: 245 opt: 682 Z-score: 433.9 bits: 90.7 E(32554): 7.6e-18
Smith-Waterman score: 682; 42.8% identity (70.6% similar) in 269 aa overlap (9-273:62-318)
10 20 30
pF1KE0 MDDAAVLKRRGYL-LGINLGEGSYAKVKSAYSERLKFN
: :: . ..:.:..: :: : : .
CCDS83 PGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAK
40 50 60 70 80 90
40 50 60 70 80 90
pF1KE0 VAIKIIDRKKAPADFLEKFLPREIEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGD
:::::::. . . :.:.. ::..:. :: : ::. :...:: . .:.: : : :.
CCDS83 VAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPHIIRLYQVMETER-MIYLVTEYASGGE
100 110 120 130 140
100 110 120 130 140 150
pF1KE0 LLELIKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSF
... . ..: . : :::.::.:. :. .:: ..:::::: .::::: ..:::..::.:
CCDS83 IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF
150 160 170 180 190 200
160 170 180 190 200 210
pF1KE0 SKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIPYQ-PKVYDIWSLGVILYIMVCGSMPY
:. :. : ::.:::: :::::...: :. ::: :::::::.::..:::..:.
CCDS83 SNLF---TPGQ--LLKTWCGSPPYAAPELFEGKEYDGPKV-DIWSLGVVLYVLVCGALPF
210 220 230 240 250 260
220 230 240 250 260 270
pF1KE0 DDSNIKKM-LRIQK-EHRVNFPRSKHLTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQP
: :..... :. . . :. : .. ::. :: ::: : :.:: ...: .: ::.
CCDS83 DGSTLQNLRARVLSGKFRIPF----FMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKL
270 280 290 300 310
280 290 300 310 320 330
pF1KE0 KARGSPSVAINKEGESSRGTEPLWTPEPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQ
CCDS83 GDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIY
320 330 340 350 360 370
>>CCDS8347.1 SIK2 gene_id:23235|Hs108|chr11 (926 aa)
initn: 762 init1: 247 opt: 662 Z-score: 423.6 bits: 88.3 E(32554): 2.8e-17
Smith-Waterman score: 662; 43.1% identity (70.2% similar) in 255 aa overlap (18-272:26-271)
10 20 30 40 50
pF1KE0 MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADF
::.:..: :: . . : .:::::::... :
CCDS83 MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVN
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 LEKFLPREIEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDE
::: . ::..:. ::.: ::: :...::. . .:.: : : .:.... . ..: :.:.:
CCDS83 LEK-IYREVQIMKMLDHPHIIKLYQVMETK-SMLYLVTEYAKNGEIFDYLANHGRLNESE
70 80 90 100 110
120 130 140 150 160 170
pF1KE0 ARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALS
::.:: :. :. ::: .:::::: .:::::...:::..::.:.. ::. :
CCDS83 ARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFF---KSGE--LL
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE0 KTFCGSPAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHR
:.:::: ::::::..: :. ::::.::.::..:::..:.: .. . . : :
CCDS83 ATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGR
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 VNFPRSKHLTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKARGSPSVAINKEGESSR
.: .. .:. :: .:: : ..:: : .: : ::
CCDS83 FRIPY--FMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEP
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE0 GTEPLWTPEPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFPSKPSTME
CCDS83 SIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLD
300 310 320 330 340 350
>>CCDS73034.1 MARK1 gene_id:4139|Hs108|chr1 (780 aa)
initn: 606 init1: 258 opt: 648 Z-score: 416.0 bits: 86.7 E(32554): 7.5e-17
Smith-Waterman score: 648; 39.9% identity (70.3% similar) in 263 aa overlap (12-272:60-311)
10 20 30 40
pF1KE0 MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIK
: : ..:.:..:::: : .::.:
CCDS73 QPTKSSSRQNIPRCRNSITSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVK
30 40 50 60 70 80
50 60 70 80 90 100
pF1KE0 IIDRKKAPADFLEKFLPREIEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLEL
:::. . :.:.. ::..:. .::: .:.: .:..:: . .:.::: : :....
CCDS73 IIDKTQLNPTSLQKLF-REVRIMKILNHPNIVKLFEVIETEK-TLYLVMEYASGGEVFDY
90 100 110 120 130 140
110 120 130 140 150 160
pF1KE0 IKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRC
. ..: ..: ::: ::.:. :..:::. .:::::: .::::: :.:::..::.::..
CCDS73 LVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEF
150 160 170 180 190 200
170 180 190 200 210 220
pF1KE0 LRDDSGRMALSKTFCGSPAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNI
.. :::::: :::::..:: :. :.:::::::: .: ::.:.: .:.
CCDS73 TVGNK-----LDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNL
210 220 230 240 250 260
230 240 250 260 270
pF1KE0 KKML-RIQK-EHRVNFPRSKHLTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKARGS
:.. :. . ..:. : ... .:..:. ..: . .: ...:.. ::
CCDS73 KELRERVLRGKYRIPF----YMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEE
270 280 290 300 310
280 290 300 310 320 330
pF1KE0 PSVAINKEGESSRGTEPLWTPEPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQS
CCDS73 ELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDEVMATYILLGRKPPEFEGG
320 330 340 350 360 370
367 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 04:39:53 2016 done: Sat Nov 5 04:39:53 2016
Total Scan time: 3.000 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]