Result of FASTA (omim) for pF1KE0788
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE0788, 419 aa
  1>>>pF1KE0788 419 - 419 aa - 419 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 9.7841+/-0.000501; mu= -1.5851+/- 0.031
 mean_var=609.1155+/-136.056, 0's: 0 Z-trim(120.9): 1233  B-trim: 1978 in 1/55
 Lambda= 0.051967
 statistics sampled from 34794 (36694) to 34794 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.76), E-opt: 0.2 (0.43), width:  16
 Scan time: 10.010

The best scores are:                                      opt bits E(85289)
NP_660186 (OMIM: 603014) dual specificity mitogen- ( 419) 2823 226.8 7.9e-59
NP_001284485 (OMIM: 603014) dual specificity mitog ( 426) 2799 225.0 2.8e-58
NP_001284484 (OMIM: 603014) dual specificity mitog ( 435) 2577 208.4 2.9e-53
XP_006722863 (OMIM: 603014) PREDICTED: dual specif ( 442) 2553 206.6   1e-52
NP_003001 (OMIM: 601335) dual specificity mitogen- ( 399)  995 89.7 1.4e-17
NP_001268364 (OMIM: 601335) dual specificity mitog ( 410)  995 89.7 1.4e-17
XP_005256810 (OMIM: 601335) PREDICTED: dual specif ( 281)  913 83.3 8.3e-16
NP_002749 (OMIM: 601254) dual specificity mitogen- ( 334)  912 83.4 9.5e-16
XP_011523328 (OMIM: 601254) PREDICTED: dual specif ( 337)  912 83.4 9.6e-16
XP_011523327 (OMIM: 601254) PREDICTED: dual specif ( 345)  912 83.4 9.7e-16
NP_002747 (OMIM: 602315) dual specificity mitogen- ( 318)  874 80.5 6.7e-15
XP_011522261 (OMIM: 602315) PREDICTED: dual specif ( 318)  874 80.5 6.7e-15
XP_016880348 (OMIM: 602315) PREDICTED: dual specif ( 318)  874 80.5 6.7e-15
XP_016880347 (OMIM: 602315) PREDICTED: dual specif ( 318)  874 80.5 6.7e-15
XP_005256780 (OMIM: 602315) PREDICTED: dual specif ( 318)  874 80.5 6.7e-15
NP_001303261 (OMIM: 602315) dual specificity mitog ( 318)  874 80.5 6.7e-15
XP_016880346 (OMIM: 602315) PREDICTED: dual specif ( 343)  874 80.5   7e-15
NP_659731 (OMIM: 602315) dual specificity mitogen- ( 347)  874 80.6   7e-15
NP_001317379 (OMIM: 601254) dual specificity mitog ( 278)  865 79.7   1e-14
XP_005257573 (OMIM: 601254) PREDICTED: dual specif ( 278)  865 79.7   1e-14
XP_011523329 (OMIM: 601254) PREDICTED: dual specif ( 278)  865 79.7   1e-14
XP_006722038 (OMIM: 601254) PREDICTED: dual specif ( 278)  865 79.7   1e-14
XP_005256812 (OMIM: 601335) PREDICTED: dual specif ( 253)  844 78.1 2.8e-14
XP_011522279 (OMIM: 601335) PREDICTED: dual specif ( 253)  844 78.1 2.8e-14
XP_011522278 (OMIM: 601335) PREDICTED: dual specif ( 319)  764 72.2   2e-12
XP_011522260 (OMIM: 602315) PREDICTED: dual specif ( 298)  682 66.1 1.4e-10
NP_001193733 (OMIM: 602520) dual specificity mitog ( 412)  618 61.5 4.6e-09
NP_660143 (OMIM: 602520) dual specificity mitogen- ( 448)  618 61.5 4.8e-09
NP_002746 (OMIM: 163950,176872,615279) dual specif ( 393)  590 59.3 1.9e-08
XP_011520085 (OMIM: 163950,176872,615279) PREDICTE ( 371)  589 59.2   2e-08
NP_109587 (OMIM: 601263,615280) dual specificity m ( 400)  579 58.5 3.4e-08
XP_016882478 (OMIM: 601263,615280) PREDICTED: dual ( 512)  579 58.7 3.9e-08
XP_011508798 (OMIM: 602255) PREDICTED: serine/thre ( 334)  545 55.9 1.8e-07
XP_016858657 (OMIM: 602255) PREDICTED: serine/thre ( 365)  545 55.9 1.9e-07
XP_016858658 (OMIM: 602255) PREDICTED: serine/thre ( 365)  545 55.9 1.9e-07
XP_011508795 (OMIM: 602255) PREDICTED: serine/thre ( 376)  540 55.6 2.5e-07
NP_006365 (OMIM: 602255) serine/threonine-protein  ( 426)  540 55.7 2.7e-07
NP_001258906 (OMIM: 602255) serine/threonine-prote ( 426)  540 55.7 2.7e-07
NP_001258907 (OMIM: 602255) serine/threonine-prote ( 426)  540 55.7 2.7e-07
NP_001027467 (OMIM: 604984) serine/threonine-prote ( 431)  522 54.3 6.9e-07
NP_003567 (OMIM: 604984) serine/threonine-protein  ( 443)  517 54.0   9e-07
XP_016876284 (OMIM: 604984) PREDICTED: serine/thre ( 474)  514 53.8 1.1e-06
XP_016876283 (OMIM: 604984) PREDICTED: serine/thre ( 517)  512 53.7 1.3e-06
NP_057626 (OMIM: 300547) serine/threonine-protein  ( 416)  502 52.8 1.9e-06
XP_016869247 (OMIM: 605030) PREDICTED: serine/thre ( 456)  501 52.8 2.1e-06
NP_006272 (OMIM: 605030) serine/threonine-protein  ( 491)  501 52.8 2.2e-06
NP_001243241 (OMIM: 605030) serine/threonine-prote ( 519)  501 52.9 2.2e-06
XP_011515553 (OMIM: 605030) PREDICTED: serine/thre ( 522)  501 52.9 2.3e-06
XP_016869246 (OMIM: 605030) PREDICTED: serine/thre ( 524)  501 52.9 2.3e-06
XP_011515550 (OMIM: 605030) PREDICTED: serine/thre ( 576)  501 52.9 2.4e-06


>>NP_660186 (OMIM: 603014) dual specificity mitogen-acti  (419 aa)
 initn: 2823 init1: 2823 opt: 2823  Z-score: 1177.1  bits: 226.8 E(85289): 7.9e-59
Smith-Waterman score: 2823; 100.0% identity (100.0% similar) in 419 aa overlap (1-419:1-419)

               10        20        30        40        50        60
pF1KE0 MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSES
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 SPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 SPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 QCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 QCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE0 HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE0 IRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 IRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDC
              310       320       330       340       350       360

              370       380       390       400       410         
pF1KE0 LTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 LTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
              370       380       390       400       410         

>>NP_001284485 (OMIM: 603014) dual specificity mitogen-a  (426 aa)
 initn: 2088 init1: 2088 opt: 2799  Z-score: 1167.3  bits: 225.0 E(85289): 2.8e-58
Smith-Waterman score: 2799; 98.4% identity (98.4% similar) in 426 aa overlap (1-419:1-426)

               10        20        30        40        50        60
pF1KE0 MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSES
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 SPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 QCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE0 HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD
              250       260       270       280       290       300

              310              320       330       340       350   
pF1KE0 IRADVWSLGISL-------VELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDF
       ::::::::::::       :::::::::::::::::::::::::::::::::::::::::
NP_001 IRADVWSLGISLPCPSPSQVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDF
              310       320       330       340       350       360

           360       370       380       390       400       410   
pF1KE0 QSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQP
              370       380       390       400       410       420

             
pF1KE0 HLPFFR
       ::::::
NP_001 HLPFFR
             

>>NP_001284484 (OMIM: 603014) dual specificity mitogen-a  (435 aa)
 initn: 2565 init1: 2565 opt: 2577  Z-score: 1077.3  bits: 208.4 E(85289): 2.9e-53
Smith-Waterman score: 2776; 96.1% identity (96.3% similar) in 435 aa overlap (1-419:1-435)

               10        20        30        40                    
pF1KE0 MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRP----------------TLQ
       :::::::::::::::::::::::::::::::::::::::::                .::
NP_001 MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPIIVITLSPAPAPSQRAALQ
               10        20        30        40        50        60

           50        60        70        80        90       100    
pF1KE0 LPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTG
               70        80        90       100       110       120

          110       120       130       140       150       160    
pF1KE0 YLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRIL
              130       140       150       160       170       180

          170       180       190       200       210       220    
pF1KE0 MDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTV
              190       200       210       220       230       240

          230       240       250       260       270       280    
pF1KE0 AIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYM
              250       260       270       280       290       300

          290       300       310       320       330       340    
pF1KE0 APERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLP
              310       320       330       340       350       360

          350       360       370       380       390       400    
pF1KE0 GHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESP
              370       380       390       400       410       420

          410         
pF1KE0 RTSGVLSQPHLPFFR
       :::::::::::::::
NP_001 RTSGVLSQPHLPFFR
              430     

>>XP_006722863 (OMIM: 603014) PREDICTED: dual specificit  (442 aa)
 initn: 1830 init1: 1830 opt: 2553  Z-score: 1067.5  bits: 206.6 E(85289): 1e-52
Smith-Waterman score: 2752; 94.6% identity (94.8% similar) in 442 aa overlap (1-419:1-442)

               10        20        30        40                    
pF1KE0 MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRP----------------TLQ
       :::::::::::::::::::::::::::::::::::::::::                .::
XP_006 MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPIIVITLSPAPAPSQRAALQ
               10        20        30        40        50        60

           50        60        70        80        90       100    
pF1KE0 LPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTG
               70        80        90       100       110       120

          110       120       130       140       150       160    
pF1KE0 YLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRIL
              130       140       150       160       170       180

          170       180       190       200       210       220    
pF1KE0 MDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTV
              190       200       210       220       230       240

          230       240       250       260       270       280    
pF1KE0 AIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYM
              250       260       270       280       290       300

          290       300       310              320       330       
pF1KE0 APERIDPPDPTKPDYDIRADVWSLGISL-------VELATGQFPYKNCKTDFEVLTKVLQ
       ::::::::::::::::::::::::::::       :::::::::::::::::::::::::
XP_006 APERIDPPDPTKPDYDIRADVWSLGISLPCPSPSQVELATGQFPYKNCKTDFEVLTKVLQ
              310       320       330       340       350       360

       340       350       360       370       380       390       
pF1KE0 EEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDV
              370       380       390       400       410       420

       400       410         
pF1KE0 MAKTESPRTSGVLSQPHLPFFR
       ::::::::::::::::::::::
XP_006 MAKTESPRTSGVLSQPHLPFFR
              430       440  

>>NP_003001 (OMIM: 601335) dual specificity mitogen-acti  (399 aa)
 initn: 1005 init1: 390 opt: 995  Z-score: 436.6  bits: 89.7 E(85289): 1.4e-17
Smith-Waterman score: 1000; 44.6% identity (70.9% similar) in 392 aa overlap (39-407:4-394)

       10        20        30        40        50        60        
pF1KE0 KLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSESSPQ--HPT
                                     : :.     .. .:: .:.  .::   ::.
NP_003                            MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPA
                                          10        20        30   

         70                  80            90       100       110  
pF1KE0 PPARP--RHMLGL----P----STLFT----PRSMESIEIDQKLQEIMKQTGYLTIGG-Q
         .    :. : :    :    .. ::    : .... .:..   . ....: : :.  :
NP_003 VSSMQGKRKALKLNFANPPFKSTARFTLNPNPTGVQNPHIERLRTHSIESSGKLKISPEQ
            40        50        60        70        80        90   

             120       130       140       150       160       170 
pF1KE0 RYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVL
       ...   .::..:::.: :. :.: ::  . .:...:::..: . ...:.:..:::::::.
NP_003 HWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVM
           100       110       120       130       140       150   

             180       190       200           210       220       
pF1KE0 KSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKR----MQGPIPERILGKMTVAIV
       .: ::::::: .:... . : .: ::::.:  .:. :     ..  :::.::::.:.: :
NP_003 RSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATV
           160       170       180       190       200       210   

       230       240       250       260       270       280       
pF1KE0 KALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPE
       ::: .:::.  .::::.::::::::. :.::::::::::.:::: ::::.:::  :::::
NP_003 KALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPE
           220       230       240       250       260       270   

       290       300       310       320       330       340       
pF1KE0 RIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPG--
       :::: . ..  ::.:.:::::::.: :::::.::: . .. :. ::.:.. .:: : .  
NP_003 RIDP-SASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSE
            280       290       300       310       320       330  

         350       360       370       380       390       400     
pF1KE0 HMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPR
       .  :: .: .::. :::::. :::::..::.: ::  ::   :.:: .   .. .  .  
NP_003 EREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQMPATP
            340       350       360       370       380       390  

         410         
pF1KE0 TSGVLSQPHLPFFR
       .:            
NP_003 SSPMYVD       
                     

>>NP_001268364 (OMIM: 601335) dual specificity mitogen-a  (410 aa)
 initn: 722 init1: 390 opt: 995  Z-score: 436.5  bits: 89.7 E(85289): 1.4e-17
Smith-Waterman score: 995; 48.3% identity (75.8% similar) in 331 aa overlap (84-407:76-405)

            60        70        80        90       100       110   
pF1KE0 RSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGG-QR
                                     : .... .:..   . ....: : :.  :.
NP_001 EKAQSKRKALKLNFANPPFKSTARFTLNPNPTGVQNPHIERLRTHSIESSGKLKISPEQH
          50        60        70        80        90       100     

            120       130       140       150       160       170  
pF1KE0 YQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLK
       ..   .::..:::.: :. :.: ::  . .:...:::..: . ...:.:..:::::::..
NP_001 WDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMR
         110       120       130       140       150       160     

            180       190       200           210       220        
pF1KE0 SHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKR----MQGPIPERILGKMTVAIVK
       : ::::::: .:... . : .: ::::.:  .:. :     ..  :::.::::.:.: ::
NP_001 SSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVK
         170       180       190       200       210       220     

      230       240       250       260       270       280        
pF1KE0 ALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPER
       :: .:::.  .::::.::::::::. :.::::::::::.:::: ::::.:::  ::::::
NP_001 ALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPER
         230       240       250       260       270       280     

      290       300       310       320       330       340        
pF1KE0 IDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPG--H
       ::: . ..  ::.:.:::::::.: :::::.::: . .. :. ::.:.. .:: : .  .
NP_001 IDP-SASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEE
          290       300       310       320       330       340    

        350       360       370       380       390       400      
pF1KE0 MGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRT
         :: .: .::. :::::. :::::..::.: ::  ::   :.:: .   .. .  .  .
NP_001 REFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQMPATPS
          350       360       370       380       390       400    

        410         
pF1KE0 SGVLSQPHLPFFR
       :            
NP_001 SPMYVD       
          410       

>>XP_005256810 (OMIM: 601335) PREDICTED: dual specificit  (281 aa)
 initn: 896 init1: 390 opt: 913  Z-score: 404.8  bits: 83.3 E(85289): 8.3e-16
Smith-Waterman score: 913; 52.0% identity (76.9% similar) in 277 aa overlap (137-407:1-276)

        110       120       130       140       150       160      
pF1KE0 TIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMD
                                     :  . .:...:::..: . ...:.:..:::
XP_005                               MVHKPSGQIMAVKRIRSTVDEKEQKQLLMD
                                             10        20        30

        170       180       190       200           210       220  
pF1KE0 LDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKR----MQGPIPERILGKM
       ::::..: ::::::: .:... . : .: ::::.:  .:. :     ..  :::.::::.
XP_005 LDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKI
               40        50        60        70        80        90

            230       240       250       260       270       280  
pF1KE0 TVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAA
       :.: :::: .:::.  .::::.::::::::. :.::::::::::.:::: ::::.:::  
XP_005 TLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRP
              100       110       120       130       140       150

            290       300       310       320       330       340  
pF1KE0 YMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPL
       ::::::::: . ..  ::.:.:::::::.: :::::.::: . .. :. ::.:.. .:: 
XP_005 YMAPERIDP-SASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQ
               160       170       180       190       200         

              350       360       370       380       390       400
pF1KE0 LPG--HMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAK
       : .  .  :: .: .::. :::::. :::::..::.: ::  ::   :.:: .   .. .
XP_005 LSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQ
     210       220       230       240       250       260         

              410         
pF1KE0 TESPRTSGVLSQPHLPFFR
         .  .:            
XP_005 MPATPSSPMYVD       
     270       280        

>>NP_002749 (OMIM: 601254) dual specificity mitogen-acti  (334 aa)
 initn: 769 init1: 359 opt: 912  Z-score: 403.7  bits: 83.4 E(85289): 9.5e-16
Smith-Waterman score: 917; 42.9% identity (72.5% similar) in 345 aa overlap (58-398:2-332)

        30        40        50        60        70         80      
pF1KE0 IDLNLDISPQRPRPTLQLPLANDGGSRSPSSESSPQHPTPPAR-PRHMLGLPSTLFTPRS
                                     :.:. .. .:  . :.. .  :.:  ::  
NP_002                              MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPR
                                            10        20        30 

         90       100       110       120       130       140      
pF1KE0 MESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVI
           ..:.:        . ..::.: .... .::: . :.: :. : : :::   .:...
NP_002 ----DLDSK--------ACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIM
                          40        50        60        70         

        150       160       170       180       190       200      
pF1KE0 AVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKL
       :::..: . :..:.::.:::::. ... :::. :  .:... . ::.: :::: :  .:.
NP_002 AVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKF
      80        90       100       110       120       130         

        210          220       230       240       250       260   
pF1KE0 KKRM--QGP-IPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFG
        :..  .:  ::: ::::..:.::::: .:. : .::::::::::.:..  ::.:.::::
NP_002 YKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFG
     140       150       160       170       180       190         

           270       280       290       300       310       320   
pF1KE0 ISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYK
       ::: :::: ::: .:::  :::::::.: . ..  :....:.:::::...:::  .::: 
NP_002 ISGYLVDSVAKTIDAGCKPYMAPERINP-ELNQKGYSVKSDIWSLGITMIELAILRFPYD
     200       210       220        230       240       250        

           330       340       350       360       370       380   
pF1KE0 NCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRY
       .  : :. : .:..:  : ::.   ::..: .:...:: :. ..:: : .:..: :.  .
NP_002 SWGTPFQQLKQVVEEPSPQLPADK-FSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLH
      260       270       280        290       300       310       

           390       400       410         
pF1KE0 ETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
       :.  .::::. : ..                     
NP_002 ESKGTDVASFVKLILGD                   
       320       330                       

>>XP_011523328 (OMIM: 601254) PREDICTED: dual specificit  (337 aa)
 initn: 921 init1: 359 opt: 912  Z-score: 403.7  bits: 83.4 E(85289): 9.6e-16
Smith-Waterman score: 912; 46.6% identity (76.4% similar) in 296 aa overlap (106-398:42-335)

          80        90       100       110       120       130     
pF1KE0 GLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVW
                                     ..::.: .... .::: . :.: :. : : 
XP_011 RNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVE
              20        30        40        50        60        70 

         140       150       160       170       180       190     
pF1KE0 KMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIA
       :::   .:...:::..: . :..:.::.:::::. ... :::. :  .:... . ::.: 
XP_011 KMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWIC
              80        90       100       110       120       130 

         200       210          220       230       240       250  
pF1KE0 MELMGTCAEKLKKRM--QGP-IPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLD
       :::: :  .:. :..  .:  ::: ::::..:.::::: .:. : .::::::::::.:..
XP_011 MELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLIN
             140       150       160       170       180       190 

            260       270       280       290       300       310  
pF1KE0 ERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISL
         ::.:.::::::: :::: ::: .:::  :::::::.: . ..  :....:.:::::..
XP_011 ALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINP-ELNQKGYSVKSDIWSLGITM
             200       210       220       230        240       250

            320       330       340       350       360       370  
pF1KE0 VELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYN
       .:::  .::: .  : :. : .:..:  : ::.   ::..: .:...:: :. ..:: : 
XP_011 IELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADK-FSAEFVDFTSQCLKKNSKERPTYP
              260       270       280        290       300         

            380       390       400       410         
pF1KE0 KLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
       .:..: :.  .:.  .::::. : ..                     
XP_011 ELMQHPFFTLHESKGTDVASFVKLILGD                   
     310       320       330                          

>>XP_011523327 (OMIM: 601254) PREDICTED: dual specificit  (345 aa)
 initn: 769 init1: 359 opt: 912  Z-score: 403.6  bits: 83.4 E(85289): 9.7e-16
Smith-Waterman score: 912; 46.6% identity (76.4% similar) in 296 aa overlap (106-398:50-343)

          80        90       100       110       120       130     
pF1KE0 GLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVW
                                     ..::.: .... .::: . :.: :. : : 
XP_011 RNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVE
      20        30        40        50        60        70         

         140       150       160       170       180       190     
pF1KE0 KMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIA
       :::   .:...:::..: . :..:.::.:::::. ... :::. :  .:... . ::.: 
XP_011 KMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWIC
      80        90       100       110       120       130         

         200       210          220       230       240       250  
pF1KE0 MELMGTCAEKLKKRM--QGP-IPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLD
       :::: :  .:. :..  .:  ::: ::::..:.::::: .:. : .::::::::::.:..
XP_011 MELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLIN
     140       150       160       170       180       190         

            260       270       280       290       300       310  
pF1KE0 ERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISL
         ::.:.::::::: :::: ::: .:::  :::::::.: . ..  :....:.:::::..
XP_011 ALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINP-ELNQKGYSVKSDIWSLGITM
     200       210       220       230        240       250        

            320       330       340       350       360       370  
pF1KE0 VELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYN
       .:::  .::: .  : :. : .:..:  : ::.   ::..: .:...:: :. ..:: : 
XP_011 IELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADK-FSAEFVDFTSQCLKKNSKERPTYP
      260       270       280       290        300       310       

            380       390       400       410         
pF1KE0 KLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
       .:..: :.  .:.  .::::. : ..                     
XP_011 ELMQHPFFTLHESKGTDVASFVKLILGD                   
       320       330       340                        




419 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 03:09:29 2016 done: Sat Nov  5 03:09:31 2016
 Total Scan time: 10.010 Total Display time:  0.050

Function used was FASTA [36.3.4 Apr, 2011]
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