Result of FASTA (omim) for pF1KE4277
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE4277, 1280 aa
  1>>>pF1KE4277     1280 - 1280 aa - 1280 aa
Library: /omim/omim.rfq.tfa
  64092750 residues in 91774 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 10.5964+/-0.000509; mu= -2.1070+/- 0.031
 mean_var=297.9807+/-61.529, 0's: 0 Z-trim(116.6): 80  B-trim: 414 in 1/54
 Lambda= 0.074299
 statistics sampled from 28911 (28991) to 28911 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.659), E-opt: 0.2 (0.316), width:  16
 Scan time:  8.950

The best scores are:                                      opt bits E(91774)
NP_733793 (OMIM: 606136) ras GTPase-activating pro (1280) 8403 916.0       0
XP_011508469 (OMIM: 606136) ras GTPase-activating  (1287) 8379 913.4       0
XP_011508468 (OMIM: 606136) ras GTPase-activating  (1290) 8042 877.3       0
XP_016858341 (OMIM: 606136) ras GTPase-activating  (1409) 7950 867.4       0
XP_016858339 (OMIM: 606136) ras GTPase-activating  (1416) 7926 864.9       0
XP_016858340 (OMIM: 606136) ras GTPase-activating  (1412) 7613 831.3       0
XP_016858342 (OMIM: 606136) ras GTPase-activating  (1234) 7590 828.8       0
XP_016858338 (OMIM: 606136) ras GTPase-activating  (1419) 7589 828.7       0
NP_004832 (OMIM: 606136) ras GTPase-activating pro (1139) 7341 802.1       0
XP_016858344 (OMIM: 606136) ras GTPase-activating  (1138) 7028 768.5       0
XP_005245679 (OMIM: 606136) ras GTPase-activating  (1142) 7004 766.0       0
XP_016858343 (OMIM: 606136) ras GTPase-activating  (1145) 7004 766.0       0
NP_115941 (OMIM: 609205) disabled homolog 2-intera (1132) 3357 375.0 1.7e-102
XP_011516568 (OMIM: 609205) disabled homolog 2-int (1153) 3357 375.0 1.7e-102
XP_005251778 (OMIM: 609205) disabled homolog 2-int (1161) 3357 375.0 1.7e-102
XP_011516566 (OMIM: 609205) disabled homolog 2-int (1182) 3357 375.1 1.7e-102
XP_005251776 (OMIM: 609205) disabled homolog 2-int (1189) 3357 375.1 1.7e-102
XP_024303186 (OMIM: 609205) disabled homolog 2-int (1125) 3296 368.5 1.6e-100
XP_011516569 (OMIM: 609205) disabled homolog 2-int (1131) 3239 362.4 1.1e-98
XP_011516567 (OMIM: 609205) disabled homolog 2-int (1160) 3238 362.3 1.2e-98
XP_024303185 (OMIM: 609205) disabled homolog 2-int (1128) 3125 350.2 5.1e-95
XP_016869788 (OMIM: 609205) disabled homolog 2-int (1141) 3123 350.0   6e-95
XP_016869787 (OMIM: 609205) disabled homolog 2-int (1164) 3118 349.4 8.9e-95
NP_619723 (OMIM: 609205) disabled homolog 2-intera (1065) 3110 348.5 1.5e-94
XP_016869789 (OMIM: 609205) disabled homolog 2-int (1065) 3110 348.5 1.5e-94
XP_011516572 (OMIM: 609205) disabled homolog 2-int (1065) 3110 348.5 1.5e-94
XP_011516573 (OMIM: 609205) disabled homolog 2-int (1065) 3110 348.5 1.5e-94
NP_001123538 (OMIM: 603384,612621) ras/Rap GTPase- (1292) 1730 200.7 5.9e-50
NP_006763 (OMIM: 603384,612621) ras/Rap GTPase-act (1343) 1705 198.0 3.9e-49
XP_024307424 (OMIM: 616561) RAS protein activator  (1005) 1475 173.3 8.2e-42
NP_075055 (OMIM: 616561) RAS protein activator lik (1011) 1471 172.8 1.1e-41
XP_011526488 (OMIM: 616561) RAS protein activator  (1008) 1437 169.2 1.4e-40
XP_011526489 (OMIM: 616561) RAS protein activator  ( 949) 1433 168.8 1.8e-40
XP_011526487 (OMIM: 616561) RAS protein activator  (1014) 1433 168.8 1.9e-40
NP_001334957 (OMIM: 616561) RAS protein activator  ( 568)  952 117.0 3.9e-25
NP_001334956 (OMIM: 616561) RAS protein activator  ( 574)  948 116.6 5.3e-25
NP_072179 (OMIM: 139150,605462,608354) ras GTPase- ( 870)  649 84.7 3.3e-15
NP_002881 (OMIM: 139150,605462,608354) ras GTPase- (1047)  649 84.7 3.8e-15
NP_001307751 (OMIM: 605182) ras GTPase-activating  ( 802)  434 61.6 2.7e-08
XP_011533144 (OMIM: 605182) ras GTPase-activating  ( 802)  434 61.6 2.7e-08
XP_011533143 (OMIM: 605182) ras GTPase-activating  ( 802)  434 61.6 2.7e-08
NP_031394 (OMIM: 605182) ras GTPase-activating pro ( 834)  434 61.6 2.8e-08
XP_016862459 (OMIM: 601589) ras GTPase-activating  ( 707)  379 55.7 1.4e-06
XP_024309459 (OMIM: 601589) ras GTPase-activating  ( 792)  379 55.7 1.6e-06
NP_006497 (OMIM: 601589) ras GTPase-activating pro ( 849)  379 55.7 1.7e-06
NP_001290174 (OMIM: 601589) ras GTPase-activating  ( 850)  379 55.7 1.7e-06
NP_001290175 (OMIM: 601589) ras GTPase-activating  ( 853)  379 55.7 1.7e-06
XP_011511361 (OMIM: 601589) ras GTPase-activating  ( 853)  379 55.7 1.7e-06
XP_016862458 (OMIM: 601589) ras GTPase-activating  ( 871)  379 55.7 1.7e-06
XP_016862457 (OMIM: 601589) ras GTPase-activating  ( 872)  379 55.7 1.7e-06


>>NP_733793 (OMIM: 606136) ras GTPase-activating protein  (1280 aa)
 initn: 8403 init1: 8403 opt: 8403  Z-score: 4884.2  bits: 916.0 E(91774):    0
Smith-Waterman score: 8403; 100.0% identity (100.0% similar) in 1280 aa overlap (1-1280:1-1280)

               10        20        30        40        50        60
pF1KE4 MELSPSSGGAAEALSWPEMFPALESDSPLPPEDLDAVVPVSGAVAGGMLDRILLESVCQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 MELSPSSGGAAEALSWPEMFPALESDSPLPPEDLDAVVPVSGAVAGGMLDRILLESVCQQ
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE4 QSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQEQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 QSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQEQQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE4 TDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAERSPRRRSISGTSTSEKPNSMDTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 TDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAERSPRRRSISGTSTSEKPNSMDTA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE4 NTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 NTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHES
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE4 LLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 LLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMEN
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE4 LRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 LRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFW
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE4 GEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 GEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTP
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE4 TPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 TPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELA
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE4 CALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 CALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHD
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE4 ALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 ALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEV
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE4 FASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 FASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE4 VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRE
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE4 LSVLHSLLWEVVSQLDKATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 LSVLHSLLWEVVSQLDKATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVS
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE4 GSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 GSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERES
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE4 SLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 SLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSA
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE4 PQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 PQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSE
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KE4 DFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 DFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLG
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KE4 ARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 ARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQ
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KE4 QTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 QTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKER
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KE4 LRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 LRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMA
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KE4 VEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 VEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGIS
             1210      1220      1230      1240      1250      1260

             1270      1280
pF1KE4 PTNPTKLSITENGEFKNSSC
       ::::::::::::::::::::
NP_733 PTNPTKLSITENGEFKNSSC
             1270      1280

>>XP_011508469 (OMIM: 606136) ras GTPase-activating prot  (1287 aa)
 initn: 5010 init1: 4954 opt: 8379  Z-score: 4870.2  bits: 913.4 E(91774):    0
Smith-Waterman score: 8379; 99.5% identity (99.5% similar) in 1287 aa overlap (1-1280:1-1287)

               10        20        30        40        50        60
pF1KE4 MELSPSSGGAAEALSWPEMFPALESDSPLPPEDLDAVVPVSGAVAGGMLDRILLESVCQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MELSPSSGGAAEALSWPEMFPALESDSPLPPEDLDAVVPVSGAVAGGMLDRILLESVCQQ
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE4 QSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQEQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQEQQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE4 TDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAERSPRRRSISGTSTSEKPNSMDTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAERSPRRRSISGTSTSEKPNSMDTA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE4 NTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHES
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE4 LLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMEN
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE4 LRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFW
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE4 GEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTP
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE4 TPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELA
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE4 CALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHD
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE4 ALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEV
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE4 FASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE4 VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRE
              670       680       690       700       710       720

              730              740       750       760       770   
pF1KE4 LSVLHSLLWEVVSQLDK-------ATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEH
       :::::::::::::::::       ::::::::::::::::::::::::::::::::::::
XP_011 LSVLHSLLWEVVSQLDKGENSFLQATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEH
              730       740       750       760       770       780

           780       790       800       810       820       830   
pF1KE4 NSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYS
              790       800       810       820       830       840

           840       850       860       870       880       890   
pF1KE4 EKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRET
              850       860       870       880       890       900

           900       910       920       930       940       950   
pF1KE4 QSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASS
              910       920       930       940       950       960

           960       970       980       990      1000      1010   
pF1KE4 RSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRK
              970       980       990      1000      1010      1020

          1020      1030      1040      1050      1060      1070   
pF1KE4 VDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPK
             1030      1040      1050      1060      1070      1080

          1080      1090      1100      1110      1120      1130   
pF1KE4 VRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQE
             1090      1100      1110      1120      1130      1140

          1140      1150      1160      1170      1180      1190   
pF1KE4 ITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKS
             1150      1160      1170      1180      1190      1200

          1200      1210      1220      1230      1240      1250   
pF1KE4 IISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSM
             1210      1220      1230      1240      1250      1260

          1260      1270      1280
pF1KE4 QVRNGISPTNPTKLSITENGEFKNSSC
       :::::::::::::::::::::::::::
XP_011 QVRNGISPTNPTKLSITENGEFKNSSC
             1270      1280       

>>XP_011508468 (OMIM: 606136) ras GTPase-activating prot  (1290 aa)
 initn: 5010 init1: 4954 opt: 8042  Z-score: 4675.0  bits: 877.3 E(91774):    0
Smith-Waterman score: 8042; 99.4% identity (99.4% similar) in 1233 aa overlap (1-1226:1-1233)

               10        20        30        40        50        60
pF1KE4 MELSPSSGGAAEALSWPEMFPALESDSPLPPEDLDAVVPVSGAVAGGMLDRILLESVCQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MELSPSSGGAAEALSWPEMFPALESDSPLPPEDLDAVVPVSGAVAGGMLDRILLESVCQQ
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE4 QSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQEQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQEQQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE4 TDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAERSPRRRSISGTSTSEKPNSMDTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAERSPRRRSISGTSTSEKPNSMDTA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE4 NTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHES
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE4 LLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMEN
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE4 LRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFW
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE4 GEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTP
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE4 TPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELA
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE4 CALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHD
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE4 ALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEV
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE4 FASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE4 VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRE
              670       680       690       700       710       720

              730              740       750       760       770   
pF1KE4 LSVLHSLLWEVVSQLDK-------ATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEH
       :::::::::::::::::       ::::::::::::::::::::::::::::::::::::
XP_011 LSVLHSLLWEVVSQLDKGENSFLQATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEH
              730       740       750       760       770       780

           780       790       800       810       820       830   
pF1KE4 NSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYS
              790       800       810       820       830       840

           840       850       860       870       880       890   
pF1KE4 EKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRET
              850       860       870       880       890       900

           900       910       920       930       940       950   
pF1KE4 QSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASS
              910       920       930       940       950       960

           960       970       980       990      1000      1010   
pF1KE4 RSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRK
              970       980       990      1000      1010      1020

          1020      1030      1040      1050      1060      1070   
pF1KE4 VDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPK
             1030      1040      1050      1060      1070      1080

          1080      1090      1100      1110      1120      1130   
pF1KE4 VRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQE
             1090      1100      1110      1120      1130      1140

          1140      1150      1160      1170      1180      1190   
pF1KE4 ITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKS
             1150      1160      1170      1180      1190      1200

          1200      1210      1220      1230      1240      1250   
pF1KE4 IISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSM
       :::::::::::::::::::::::::::::::::                           
XP_011 IISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQVINGDEIIQTGKTDRVPGFSQHQTDER
             1210      1220      1230      1240      1250      1260

          1260      1270      1280   
pF1KE4 QVRNGISPTNPTKLSITENGEFKNSSC   
                                     
XP_011 ADPSEGAVQHAGPQWHLPHQPHQAFHHGEW
             1270      1280      1290

>>XP_016858341 (OMIM: 606136) ras GTPase-activating prot  (1409 aa)
 initn: 7950 init1: 7950 opt: 7950  Z-score: 4621.2  bits: 867.4 E(91774):    0
Smith-Waterman score: 7950; 100.0% identity (100.0% similar) in 1213 aa overlap (68-1280:197-1409)

        40        50        60        70        80        90       
pF1KE4 VPVSGAVAGGMLDRILLESVCQQQSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCIL
                                     ::::::::::::::::::::::::::::::
XP_016 FIRGIFSTLSNGFSRMLNLKGESTNEPVREDVKGPPTHRLSCGQSPYTETTTWERKYCIL
        170       180       190       200       210       220      

       100       110       120       130       140       150       
pF1KE4 TDSQLVLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDSQLVLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAE
        230       240       250       260       270       280      

       160       170       180       190       200       210       
pF1KE4 RSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLP
        290       300       310       320       330       340      

       220       230       240       250       260       270       
pF1KE4 SLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEV
        350       360       370       380       390       400      

       280       290       300       310       320       330       
pF1KE4 TYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFC
        410       420       430       440       450       460      

       340       350       360       370       380       390       
pF1KE4 ELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGL
        470       480       490       500       510       520      

       400       410       420       430       440       450       
pF1KE4 VNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVT
        530       540       550       560       570       580      

       460       470       480       490       500       510       
pF1KE4 SNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFR
        590       600       610       620       630       640      

       520       530       540       550       560       570       
pF1KE4 ENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKM
        650       660       670       680       690       700      

       580       590       600       610       620       630       
pF1KE4 CCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSP
        710       720       730       740       750       760      

       640       650       660       670       680       690       
pF1KE4 SLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLL
        770       780       790       800       810       820      

       700       710       720       730       740       750       
pF1KE4 EISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAKLGPLPRVLADITKSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAKLGPLPRVLADITKSL
        830       840       850       860       870       880      

       760       770       780       790       800       810       
pF1KE4 TNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGK
        890       900       910       920       930       940      

       820       830       840       850       860       870       
pF1KE4 TLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGS
        950       960       970       980       990      1000      

       880       890       900       910       920       930       
pF1KE4 QLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMP
       1010      1020      1030      1040      1050      1060      

       940       950       960       970       980       990       
pF1KE4 KASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIP
       1070      1080      1090      1100      1110      1120      

      1000      1010      1020      1030      1040      1050       
pF1KE4 LALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGS
       1130      1140      1150      1160      1170      1180      

      1060      1070      1080      1090      1100      1110       
pF1KE4 RSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEET
       1190      1200      1210      1220      1230      1240      

      1120      1130      1140      1150      1160      1170       
pF1KE4 EQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSE
       1250      1260      1270      1280      1290      1300      

      1180      1190      1200      1210      1220      1230       
pF1KE4 ERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSAN
       1310      1320      1330      1340      1350      1360      

      1240      1250      1260      1270      1280
pF1KE4 TRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC
       :::::::::::::::::::::::::::::::::::::::::::
XP_016 TRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC
       1370      1380      1390      1400         

>>XP_016858339 (OMIM: 606136) ras GTPase-activating prot  (1416 aa)
 initn: 4557 init1: 4501 opt: 7926  Z-score: 4607.2  bits: 864.9 E(91774):    0
Smith-Waterman score: 7926; 99.4% identity (99.4% similar) in 1220 aa overlap (68-1280:197-1416)

        40        50        60        70        80        90       
pF1KE4 VPVSGAVAGGMLDRILLESVCQQQSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCIL
                                     ::::::::::::::::::::::::::::::
XP_016 FIRGIFSTLSNGFSRMLNLKGESTNEPVREDVKGPPTHRLSCGQSPYTETTTWERKYCIL
        170       180       190       200       210       220      

       100       110       120       130       140       150       
pF1KE4 TDSQLVLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDSQLVLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAE
        230       240       250       260       270       280      

       160       170       180       190       200       210       
pF1KE4 RSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLP
        290       300       310       320       330       340      

       220       230       240       250       260       270       
pF1KE4 SLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEV
        350       360       370       380       390       400      

       280       290       300       310       320       330       
pF1KE4 TYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFC
        410       420       430       440       450       460      

       340       350       360       370       380       390       
pF1KE4 ELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGL
        470       480       490       500       510       520      

       400       410       420       430       440       450       
pF1KE4 VNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVT
        530       540       550       560       570       580      

       460       470       480       490       500       510       
pF1KE4 SNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFR
        590       600       610       620       630       640      

       520       530       540       550       560       570       
pF1KE4 ENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKM
        650       660       670       680       690       700      

       580       590       600       610       620       630       
pF1KE4 CCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSP
        710       720       730       740       750       760      

       640       650       660       670       680       690       
pF1KE4 SLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLL
        770       780       790       800       810       820      

       700       710       720       730              740       750
pF1KE4 EISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDK-------ATVAKLGPLPRVL
       ::::::::::::::::::::::::::::::::::::::::       :::::::::::::
XP_016 EISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVAKLGPLPRVL
        830       840       850       860       870       880      

              760       770       780       790       800       810
pF1KE4 ADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNT
        890       900       910       920       930       940      

              820       830       840       850       860       870
pF1KE4 DSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDV
        950       960       970       980       990      1000      

              880       890       900       910       920       930
pF1KE4 PIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLN
       1010      1020      1030      1040      1050      1060      

              940       950       960       970       980       990
pF1KE4 NPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHT
       1070      1080      1090      1100      1110      1120      

             1000      1010      1020      1030      1040      1050
pF1KE4 VPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVA
       1130      1140      1150      1160      1170      1180      

             1060      1070      1080      1090      1100      1110
pF1KE4 EPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQY
       1190      1200      1210      1220      1230      1240      

             1120      1130      1140      1150      1160      1170
pF1KE4 EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYK
       1250      1260      1270      1280      1290      1300      

             1180      1190      1200      1210      1220      1230
pF1KE4 ARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRI
       1310      1320      1330      1340      1350      1360      

             1240      1250      1260      1270      1280
pF1KE4 VSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC
       ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC
       1370      1380      1390      1400      1410      

>>XP_016858340 (OMIM: 606136) ras GTPase-activating prot  (1412 aa)
 initn: 7613 init1: 7613 opt: 7613  Z-score: 4425.9  bits: 831.3 E(91774):    0
Smith-Waterman score: 7613; 100.0% identity (100.0% similar) in 1159 aa overlap (68-1226:197-1355)

        40        50        60        70        80        90       
pF1KE4 VPVSGAVAGGMLDRILLESVCQQQSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCIL
                                     ::::::::::::::::::::::::::::::
XP_016 FIRGIFSTLSNGFSRMLNLKGESTNEPVREDVKGPPTHRLSCGQSPYTETTTWERKYCIL
        170       180       190       200       210       220      

       100       110       120       130       140       150       
pF1KE4 TDSQLVLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDSQLVLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAE
        230       240       250       260       270       280      

       160       170       180       190       200       210       
pF1KE4 RSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLP
        290       300       310       320       330       340      

       220       230       240       250       260       270       
pF1KE4 SLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEV
        350       360       370       380       390       400      

       280       290       300       310       320       330       
pF1KE4 TYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFC
        410       420       430       440       450       460      

       340       350       360       370       380       390       
pF1KE4 ELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGL
        470       480       490       500       510       520      

       400       410       420       430       440       450       
pF1KE4 VNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVT
        530       540       550       560       570       580      

       460       470       480       490       500       510       
pF1KE4 SNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFR
        590       600       610       620       630       640      

       520       530       540       550       560       570       
pF1KE4 ENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKM
        650       660       670       680       690       700      

       580       590       600       610       620       630       
pF1KE4 CCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSP
        710       720       730       740       750       760      

       640       650       660       670       680       690       
pF1KE4 SLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLL
        770       780       790       800       810       820      

       700       710       720       730       740       750       
pF1KE4 EISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAKLGPLPRVLADITKSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAKLGPLPRVLADITKSL
        830       840       850       860       870       880      

       760       770       780       790       800       810       
pF1KE4 TNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGK
        890       900       910       920       930       940      

       820       830       840       850       860       870       
pF1KE4 TLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGS
        950       960       970       980       990      1000      

       880       890       900       910       920       930       
pF1KE4 QLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMP
       1010      1020      1030      1040      1050      1060      

       940       950       960       970       980       990       
pF1KE4 KASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIP
       1070      1080      1090      1100      1110      1120      

      1000      1010      1020      1030      1040      1050       
pF1KE4 LALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGS
       1130      1140      1150      1160      1170      1180      

      1060      1070      1080      1090      1100      1110       
pF1KE4 RSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEET
       1190      1200      1210      1220      1230      1240      

      1120      1130      1140      1150      1160      1170       
pF1KE4 EQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSE
       1250      1260      1270      1280      1290      1300      

      1180      1190      1200      1210      1220      1230       
pF1KE4 ERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSAN
       :::::::::::::::::::::::::::::::::::::::::::::::::           
XP_016 ERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQVINGDEIIQTG
       1310      1320      1330      1340      1350      1360      

      1240      1250      1260      1270      1280   
pF1KE4 TRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC   
                                                     
XP_016 KTDRVPGFSQHQTDERADPSEGAVQHAGPQWHLPHQPHQAFHHGEW
       1370      1380      1390      1400      1410  

>>XP_016858342 (OMIM: 606136) ras GTPase-activating prot  (1234 aa)
 initn: 4557 init1: 4501 opt: 7590  Z-score: 4413.4  bits: 828.8 E(91774):    0
Smith-Waterman score: 7590; 99.1% identity (99.1% similar) in 1171 aa overlap (63-1226:9-1177)

             40        50        60        70        80        90  
pF1KE4 DLDAVVPVSGAVAGGMLDRILLESVCQQQSWVRVYDVKGPPTHRLSCGQSPYTETTTWER
                                     : .  :::::::::::::::::::::::::
XP_016                       MMENALHLWEK--DVKGPPTHRLSCGQSPYTETTTWER
                                     10          20        30      

            100       110       120       130       140       150  
pF1KE4 KYCILTDSQLVLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KYCILTDSQLVLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKL
         40        50        60        70        80        90      

            160       170       180       190       200       210  
pF1KE4 EVPAERSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVPAERSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNT
        100       110       120       130       140       150      

            220       230       240       250       260       270  
pF1KE4 SFRLPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFRLPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQD
        160       170       180       190       200       210      

            280       290       300       310       320       330  
pF1KE4 FCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPK
        220       230       240       250       260       270      

            340       350       360       370       380       390  
pF1KE4 KKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKN
        280       290       300       310       320       330      

            400       410       420       430       440       450  
pF1KE4 NYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEF
        340       350       360       370       380       390      

            460       470       480       490       500       510  
pF1KE4 AEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHD
        400       410       420       430       440       450      

            520       530       540       550       560       570  
pF1KE4 VLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQ
        460       470       480       490       500       510      

            580       590       600       610       620       630  
pF1KE4 SNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCP
        520       530       540       550       560       570      

            640       650       660       670       680       690  
pF1KE4 AIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGM
        580       590       600       610       620       630      

            700       710       720       730              740     
pF1KE4 KRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDK-------ATVAKLGP
       :::::::::::::::::::::::::::::::::::::::::::::       ::::::::
XP_016 KRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVAKLGP
        640       650       660       670       680       690      

         750       760       770       780       790       800     
pF1KE4 LPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSP
        700       710       720       730       740       750      

         810       820       830       840       850       860     
pF1KE4 SQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHAS
        760       770       780       790       800       810      

         870       880       890       900       910       920     
pF1KE4 VMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNP
        820       830       840       850       860       870      

         930       940       950       960       970       980     
pF1KE4 VYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDF
        880       890       900       910       920       930      

         990      1000      1010      1020      1030      1040     
pF1KE4 SRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVS
        940       950       960       970       980       990      

        1050      1060      1070      1080      1090      1100     
pF1KE4 AALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVL
       1000      1010      1020      1030      1040      1050      

        1110      1120      1130      1140      1150      1160     
pF1KE4 NNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKL
       1060      1070      1080      1090      1100      1110      

        1170      1180      1190      1200      1210      1220     
pF1KE4 LLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDA
       1120      1130      1140      1150      1160      1170      

        1230      1240      1250      1260      1270      1280   
pF1KE4 QEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC   
       :                                                         
XP_016 QVINGDEIIQTGKTDRVPGFSQHQTDERADPSEGAVQHAGPQWHLPHQPHQAFHHGEW
       1180      1190      1200      1210      1220      1230    

>>XP_016858338 (OMIM: 606136) ras GTPase-activating prot  (1419 aa)
 initn: 4557 init1: 4501 opt: 7589  Z-score: 4412.0  bits: 828.7 E(91774):    0
Smith-Waterman score: 7589; 99.4% identity (99.4% similar) in 1166 aa overlap (68-1226:197-1362)

        40        50        60        70        80        90       
pF1KE4 VPVSGAVAGGMLDRILLESVCQQQSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCIL
                                     ::::::::::::::::::::::::::::::
XP_016 FIRGIFSTLSNGFSRMLNLKGESTNEPVREDVKGPPTHRLSCGQSPYTETTTWERKYCIL
        170       180       190       200       210       220      

       100       110       120       130       140       150       
pF1KE4 TDSQLVLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDSQLVLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAE
        230       240       250       260       270       280      

       160       170       180       190       200       210       
pF1KE4 RSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLP
        290       300       310       320       330       340      

       220       230       240       250       260       270       
pF1KE4 SLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEV
        350       360       370       380       390       400      

       280       290       300       310       320       330       
pF1KE4 TYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFC
        410       420       430       440       450       460      

       340       350       360       370       380       390       
pF1KE4 ELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGL
        470       480       490       500       510       520      

       400       410       420       430       440       450       
pF1KE4 VNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVT
        530       540       550       560       570       580      

       460       470       480       490       500       510       
pF1KE4 SNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFR
        590       600       610       620       630       640      

       520       530       540       550       560       570       
pF1KE4 ENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKM
        650       660       670       680       690       700      

       580       590       600       610       620       630       
pF1KE4 CCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSP
        710       720       730       740       750       760      

       640       650       660       670       680       690       
pF1KE4 SLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLL
        770       780       790       800       810       820      

       700       710       720       730              740       750
pF1KE4 EISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDK-------ATVAKLGPLPRVL
       ::::::::::::::::::::::::::::::::::::::::       :::::::::::::
XP_016 EISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVAKLGPLPRVL
        830       840       850       860       870       880      

              760       770       780       790       800       810
pF1KE4 ADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNT
        890       900       910       920       930       940      

              820       830       840       850       860       870
pF1KE4 DSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDV
        950       960       970       980       990      1000      

              880       890       900       910       920       930
pF1KE4 PIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLN
       1010      1020      1030      1040      1050      1060      

              940       950       960       970       980       990
pF1KE4 NPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHT
       1070      1080      1090      1100      1110      1120      

             1000      1010      1020      1030      1040      1050
pF1KE4 VPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVA
       1130      1140      1150      1160      1170      1180      

             1060      1070      1080      1090      1100      1110
pF1KE4 EPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQY
       1190      1200      1210      1220      1230      1240      

             1120      1130      1140      1150      1160      1170
pF1KE4 EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYK
       1250      1260      1270      1280      1290      1300      

             1180      1190      1200      1210      1220      1230
pF1KE4 ARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::    
XP_016 ARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQVING
       1310      1320      1330      1340      1350      1360      

             1240      1250      1260      1270      1280   
pF1KE4 VSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC   
                                                            
XP_016 DEIIQTGKTDRVPGFSQHQTDERADPSEGAVQHAGPQWHLPHQPHQAFHHGEW
       1370      1380      1390      1400      1410         

>>NP_004832 (OMIM: 606136) ras GTPase-activating protein  (1139 aa)
 initn: 3972 init1: 3916 opt: 7341  Z-score: 4269.7  bits: 802.1 E(91774):    0
Smith-Waterman score: 7341; 99.4% identity (99.4% similar) in 1135 aa overlap (153-1280:5-1139)

            130       140       150       160       170       180  
pF1KE4 STKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAERSPRRRSISGTSTSEKPNSMDTANT
                                     ::::::::::::::::::::::::::::::
NP_004                           MQTPEVPAERSPRRRSISGTSTSEKPNSMDTANT
                                         10        20        30    

            190       200       210       220       230       240  
pF1KE4 SPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHESLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHESLL
           40        50        60        70        80        90    

            250       260       270       280       290       300  
pF1KE4 SPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMENLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMENLR
          100       110       120       130       140       150    

            310       320       330       340       350       360  
pF1KE4 RTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGE
          160       170       180       190       200       210    

            370       380       390       400       410       420  
pF1KE4 HFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTP
          220       230       240       250       260       270    

            430       440       450       460       470       480  
pF1KE4 NKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACA
          280       290       300       310       320       330    

            490       500       510       520       530       540  
pF1KE4 LVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDAL
          340       350       360       370       380       390    

            550       560       570       580       590       600  
pF1KE4 GEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFA
          400       410       420       430       440       450    

            610       620       630       640       650       660  
pF1KE4 SWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVI
          460       470       480       490       500       510    

            670       680       690       700       710       720  
pF1KE4 QNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELS
          520       530       540       550       560       570    

            730              740       750       760       770     
pF1KE4 VLHSLLWEVVSQLDK-------ATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNS
       :::::::::::::::       ::::::::::::::::::::::::::::::::::::::
NP_004 VLHSLLWEVVSQLDKGENSFLQATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNS
          580       590       600       610       620       630    

         780       790       800       810       820       830     
pF1KE4 SPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEK
          640       650       660       670       680       690    

         840       850       860       870       880       890     
pF1KE4 DERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQS
          700       710       720       730       740       750    

         900       910       920       930       940       950     
pF1KE4 TPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASSRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASSRS
          760       770       780       790       800       810    

         960       970       980       990      1000      1010     
pF1KE4 QSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVD
          820       830       840       850       860       870    

        1020      1030      1040      1050      1060      1070     
pF1KE4 QGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVR
          880       890       900       910       920       930    

        1080      1090      1100      1110      1120      1130     
pF1KE4 AIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEIT
          940       950       960       970       980       990    

        1140      1150      1160      1170      1180      1190     
pF1KE4 KLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSII
         1000      1010      1020      1030      1040      1050    

        1200      1210      1220      1230      1240      1250     
pF1KE4 SRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSMQV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSMQV
         1060      1070      1080      1090      1100      1110    

        1260      1270      1280
pF1KE4 RNGISPTNPTKLSITENGEFKNSSC
       :::::::::::::::::::::::::
NP_004 RNGISPTNPTKLSITENGEFKNSSC
         1120      1130         

>>XP_016858344 (OMIM: 606136) ras GTPase-activating prot  (1138 aa)
 initn: 7028 init1: 7028 opt: 7028  Z-score: 4088.4  bits: 768.5 E(91774):    0
Smith-Waterman score: 7028; 100.0% identity (100.0% similar) in 1074 aa overlap (153-1226:8-1081)

            130       140       150       160       170       180  
pF1KE4 STKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAERSPRRRSISGTSTSEKPNSMDTANT
                                     ::::::::::::::::::::::::::::::
XP_016                        MGSSCDKEVPAERSPRRRSISGTSTSEKPNSMDTANT
                                      10        20        30       

            190       200       210       220       230       240  
pF1KE4 SPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHESLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHESLL
        40        50        60        70        80        90       

            250       260       270       280       290       300  
pF1KE4 SPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMENLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMENLR
       100       110       120       130       140       150       

            310       320       330       340       350       360  
pF1KE4 RTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGE
       160       170       180       190       200       210       

            370       380       390       400       410       420  
pF1KE4 HFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTP
       220       230       240       250       260       270       

            430       440       450       460       470       480  
pF1KE4 NKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACA
       280       290       300       310       320       330       

            490       500       510       520       530       540  
pF1KE4 LVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDAL
       340       350       360       370       380       390       

            550       560       570       580       590       600  
pF1KE4 GEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFA
       400       410       420       430       440       450       

            610       620       630       640       650       660  
pF1KE4 SWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVI
       460       470       480       490       500       510       

            670       680       690       700       710       720  
pF1KE4 QNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELS
       520       530       540       550       560       570       

            730       740       750       760       770       780  
pF1KE4 VLHSLLWEVVSQLDKATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLHSLLWEVVSQLDKATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGS
       580       590       600       610       620       630       

            790       800       810       820       830       840  
pF1KE4 LSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSL
       640       650       660       670       680       690       

            850       860       870       880       890       900  
pF1KE4 PNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQ
       700       710       720       730       740       750       

            910       920       930       940       950       960  
pF1KE4 VRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDF
       760       770       780       790       800       810       

            970       980       990      1000      1010      1020  
pF1KE4 KLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGAR
       820       830       840       850       860       870       

           1030      1040      1050      1060      1070      1080  
pF1KE4 AKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQT
       880       890       900       910       920       930       

           1090      1100      1110      1120      1130      1140  
pF1KE4 QQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLR
       940       950       960       970       980       990       

           1150      1160      1170      1180      1190      1200  
pF1KE4 VSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVE
      1000      1010      1020      1030      1040      1050       

           1210      1220      1230      1240      1250      1260  
pF1KE4 EELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPT
       ::::::::::::::::::::::::                                    
XP_016 EELKKDHAEMQAVIDAKQKIIDAQVINGDEIIQTGKTDRVPGFSQHQTDERADPSEGAVQ
      1060      1070      1080      1090      1100      1110       




1280 residues in 1 query   sequences
64092750 residues in 91774 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Tue Jul 16 15:46:51 2019 done: Tue Jul 16 15:46:53 2019
 Total Scan time:  8.950 Total Display time:  0.390

Function used was FASTA [36.3.4 Apr, 2011]
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