Result of FASTA (omim) for pF1KE1947
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE1947, 501 aa
  1>>>pF1KE1947     501 - 501 aa - 501 aa
Library: /omim/omim.rfq.tfa
  64440809 residues in 90964 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 4.9065+/-0.000359; mu= 20.5585+/- 0.022
 mean_var=67.3780+/-13.601, 0's: 0 Z-trim(113.9): 34  B-trim: 1425 in 1/50
 Lambda= 0.156248
 statistics sampled from 24200 (24234) to 24200 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.635), E-opt: 0.2 (0.266), width:  16
 Scan time:  4.320

The best scores are:                                      opt bits E(90964)
NP_036236 (OMIM: 604252) beta-secretase 1 isoform  ( 501) 3417 779.4       0
NP_001193977 (OMIM: 604252) beta-secretase 1 isofo ( 401) 2607 596.8 4.2e-170
NP_620427 (OMIM: 604252) beta-secretase 1 isoform  ( 457) 2144 492.4 1.2e-138
NP_001193978 (OMIM: 604252) beta-secretase 1 isofo ( 376) 1960 450.9 3.2e-126
NP_620428 (OMIM: 604252) beta-secretase 1 isoform  ( 476) 1960 451.0 3.8e-126
NP_620429 (OMIM: 604252) beta-secretase 1 isoform  ( 432) 1959 450.7 4.1e-126
NP_036237 (OMIM: 605668) beta-secretase 2 isoform  ( 518) 1535 355.2 2.8e-97
XP_016883803 (OMIM: 605668) beta-secretase 2 isofo ( 423) 1391 322.7 1.4e-87
NP_620477 (OMIM: 605668) beta-secretase 2 isoform  ( 396) 1249 290.6 5.8e-78
NP_620476 (OMIM: 605668) beta-secretase 2 isoform  ( 468) 1041 243.8 8.6e-64
XP_011507546 (OMIM: 116890) cathepsin E isoform X1 ( 401)  337 85.1 4.5e-16
NP_001901 (OMIM: 116890) cathepsin E isoform a pre ( 396)  321 81.4 5.5e-15
NP_001304260 (OMIM: 116890) cathepsin E isoform c  ( 288)  308 78.4 3.3e-14
NP_683865 (OMIM: 116890) cathepsin E isoform b pre ( 363)  308 78.5 3.9e-14
XP_011507547 (OMIM: 116890) cathepsin E isoform X2 ( 368)  298 76.2 1.9e-13
NP_001900 (OMIM: 116840,610127) cathepsin D prepro ( 412)  267 69.3 2.6e-11
NP_000528 (OMIM: 179820,267430,613092) renin prepr ( 406)  258 67.3 1.1e-10
NP_004842 (OMIM: 605631) napsin-A preproprotein [H ( 420)  253 66.1 2.4e-10
XP_011525842 (OMIM: 605631) napsin-A isoform X1 [H ( 420)  253 66.1 2.4e-10
NP_002621 (OMIM: 169740) gastricsin isoform 1 prep ( 388)  240 63.2 1.7e-09
XP_016883001 (OMIM: 605631) napsin-A isoform X2 [H ( 411)  188 51.5   6e-06
NP_055039 (OMIM: 169730) pepsin A-5 preproprotein  ( 388)  154 43.8  0.0012
NP_001073275 (OMIM: 169710) pepsin A-3 preproprote ( 388)  153 43.6  0.0014
NP_001073276 (OMIM: 169720) pepsin A-4 preproprote ( 388)  153 43.6  0.0014
NP_001159896 (OMIM: 169740) gastricsin isoform 2 p ( 315)  149 42.6  0.0022


>>NP_036236 (OMIM: 604252) beta-secretase 1 isoform A pr  (501 aa)
 initn: 3417 init1: 3417 opt: 3417  Z-score: 4160.9  bits: 779.4 E(90964):    0
Smith-Waterman score: 3417; 100.0% identity (100.0% similar) in 501 aa overlap (1-501:1-501)

               10        20        30        40        50        60
pF1KE1 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE1 GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE1 DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE1 VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE1 ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE1 HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
              430       440       450       460       470       480

              490       500 
pF1KE1 RCLRCLRQQHDDFADDISLLK
       :::::::::::::::::::::
NP_036 RCLRCLRQQHDDFADDISLLK
              490       500 

>>NP_001193977 (OMIM: 604252) beta-secretase 1 isoform E  (401 aa)
 initn: 2607 init1: 2607 opt: 2607  Z-score: 3175.4  bits: 596.8 E(90964): 4.2e-170
Smith-Waterman score: 2607; 100.0% identity (100.0% similar) in 384 aa overlap (118-501:18-401)

        90       100       110       120       130       140       
pF1KE1 LNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVS
                                     ::::::::::::::::::::::::::::::
NP_001              MVPFIYLQAHFTLCSGWSSTYRDLRKGVYVPYTQGKWEGELGTDLVS
                            10        20        30        40       

       150       160       170       180       190       200       
pF1KE1 IPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHV
        50        60        70        80        90       100       

       210       220       230       240       250       260       
pF1KE1 PNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRV
       110       120       130       140       150       160       

       270       280       290       300       310       320       
pF1KE1 EINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQ
       170       180       190       200       210       220       

       330       340       350       360       370       380       
pF1KE1 LVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQ
       230       240       250       260       270       280       

       390       400       410       420       430       440       
pF1KE1 SSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNI
       290       300       310       320       330       340       

       450       460       470       480       490       500 
pF1KE1 PQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK
       350       360       370       380       390       400 

>>NP_620427 (OMIM: 604252) beta-secretase 1 isoform C pr  (457 aa)
 initn: 3118 init1: 2130 opt: 2144  Z-score: 2610.6  bits: 492.4 E(90964): 1.2e-138
Smith-Waterman score: 3034; 91.2% identity (91.2% similar) in 501 aa overlap (1-501:1-457)

               10        20        30        40        50        60
pF1KE1 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
       :::::::::::::::::::::::::                                   
NP_620 YRDLRKGVYVPYTQGKWEGELGTDL-----------------------------------
              130       140                                        

              190       200       210       220       230       240
pF1KE1 GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
                :::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 ---------PDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
                  150       160       170       180       190      

              250       260       270       280       290       300
pF1KE1 DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
        200       210       220       230       240       250      

              310       320       330       340       350       360
pF1KE1 VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
        260       270       280       290       300       310      

              370       380       390       400       410       420
pF1KE1 ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
        320       330       340       350       360       370      

              430       440       450       460       470       480
pF1KE1 HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
        380       390       400       410       420       430      

              490       500 
pF1KE1 RCLRCLRQQHDDFADDISLLK
       :::::::::::::::::::::
NP_620 RCLRCLRQQHDDFADDISLLK
        440       450       

>>NP_001193978 (OMIM: 604252) beta-secretase 1 isoform F  (376 aa)
 initn: 1960 init1: 1960 opt: 1960  Z-score: 2387.6  bits: 450.9 E(90964): 3.2e-126
Smith-Waterman score: 2376; 93.5% identity (93.5% similar) in 384 aa overlap (118-501:18-376)

        90       100       110       120       130       140       
pF1KE1 LNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVS
                                     ::::::::::::::::::::::::::::::
NP_001              MVPFIYLQAHFTLCSGWSSTYRDLRKGVYVPYTQGKWEGELGTDLVS
                            10        20        30        40       

       150       160       170       180       190       200       
pF1KE1 IPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHV
       ::::::::::::::::::::::::::::::::::::::::::                  
NP_001 IPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIAR------------------
        50        60        70        80                           

       210       220       230       240       250       260       
pF1KE1 PNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRV
              :::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -------LCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRV
             90       100       110       120       130       140  

       270       280       290       300       310       320       
pF1KE1 EINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQ
            150       160       170       180       190       200  

       330       340       350       360       370       380       
pF1KE1 LVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQ
            210       220       230       240       250       260  

       390       400       410       420       430       440       
pF1KE1 SSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNI
            270       280       290       300       310       320  

       450       460       470       480       490       500 
pF1KE1 PQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK
            330       340       350       360       370      

>>NP_620428 (OMIM: 604252) beta-secretase 1 isoform B pr  (476 aa)
 initn: 1960 init1: 1960 opt: 1960  Z-score: 2386.2  bits: 451.0 E(90964): 3.8e-126
Smith-Waterman score: 3186; 95.0% identity (95.0% similar) in 501 aa overlap (1-501:1-476)

               10        20        30        40        50        60
pF1KE1 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE1 GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
       :::::::::                         ::::::::::::::::::::::::::
NP_620 GLAYAEIAR-------------------------LCGAGFPLNQSEVLASVGGSMIIGGI
                                       190       200       210     

              250       260       270       280       290       300
pF1KE1 DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
         220       230       240       250       260       270     

              310       320       330       340       350       360
pF1KE1 VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
         280       290       300       310       320       330     

              370       380       390       400       410       420
pF1KE1 ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
         340       350       360       370       380       390     

              430       440       450       460       470       480
pF1KE1 HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
         400       410       420       430       440       450     

              490       500 
pF1KE1 RCLRCLRQQHDDFADDISLLK
       :::::::::::::::::::::
NP_620 RCLRCLRQQHDDFADDISLLK
         460       470      

>>NP_620429 (OMIM: 604252) beta-secretase 1 isoform D pr  (432 aa)
 initn: 1959 init1: 1959 opt: 1959  Z-score: 2385.6  bits: 450.7 E(90964): 4.1e-126
Smith-Waterman score: 2813; 86.2% identity (86.2% similar) in 501 aa overlap (1-501:1-432)

               10        20        30        40        50        60
pF1KE1 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
       :::::::::::::::::::::::::                                   
NP_620 YRDLRKGVYVPYTQGKWEGELGTDL-----------------------------------
              130       140                                        

              190       200       210       220       230       240
pF1KE1 GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
                                         ::::::::::::::::::::::::::
NP_620 ----------------------------------LCGAGFPLNQSEVLASVGGSMIIGGI
                                           150       160       170 

              250       260       270       280       290       300
pF1KE1 DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
             180       190       200       210       220       230 

              310       320       330       340       350       360
pF1KE1 VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
             240       250       260       270       280       290 

              370       380       390       400       410       420
pF1KE1 ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
             300       310       320       330       340       350 

              430       440       450       460       470       480
pF1KE1 HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
             360       370       380       390       400       410 

              490       500 
pF1KE1 RCLRCLRQQHDDFADDISLLK
       :::::::::::::::::::::
NP_620 RCLRCLRQQHDDFADDISLLK
             420       430  

>>NP_036237 (OMIM: 605668) beta-secretase 2 isoform A pr  (518 aa)
 initn: 1512 init1: 668 opt: 1535  Z-score: 1867.9  bits: 355.2 E(90964): 2.8e-97
Smith-Waterman score: 1535; 49.6% identity (77.0% similar) in 448 aa overlap (54-500:71-512)

            30        40        50        60        70        80   
pF1KE1 HGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGS
                                     :.  ..:. :::::.: ::.:::.:: .:.
NP_036 RVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGT
               50        60        70        80        90       100

            90       100       110       120       130       140   
pF1KE1 PPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGT
       ::: :.::::::::::::...:: ..  :.. . :::::.    : : ::::.: : .: 
NP_036 PPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGE
              110       120       130       140       150       160

           150       160       170       180       190       200   
pF1KE1 DLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVK
       :::.::.: :..  .:::.: ::..::. : .:.:::::::: .:.:..::: :::::: 
NP_036 DLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVT
              170       180       190       200       210       220

           210       220       230       240       250       260   
pF1KE1 QTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVI
       :...::.::.:.::::.:.  :   .. :::...:::. ::: :..:::::..::::.. 
NP_036 QANIPNVFSMQMCGAGLPVAGS---GTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIE
              230       240          250       260       270       

           270       280       290       300       310       320   
pF1KE1 IVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFW
       :...::.::.:..::.::: ::.::::::: ::::.:::.:.:...  ::   .: ::::
NP_036 ILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFW
       280       290       300       310       320       330       

           330       340       350       360       370       380   
pF1KE1 LGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKF
        : ::.::  . :::. :: ::.::  : ...::::::::: :..:.  .. . . ::.:
NP_036 TGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYE-CYRF
       340       350       360       370       380       390       

           390       400       410       420       430       440   
pF1KE1 AISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDC
       .:: :... :.::..::::::.::::.::.:::.: :       .. . ::: : :. . 
NP_036 GISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASN
        400       410       420       430       440       450      

           450       460        470       480       490       500  
pF1KE1 GYNIPQTDESTLMTIAYVMAAIC-ALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK 
            . .:  :  ..:.. ..: :.... . :..  .:: :  : .  . ..: : :  
NP_036 CVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQR--RPRDPEVVNDESSLVR
        460       470       480       490         500       510    

NP_036 HRWK
           

>>XP_016883803 (OMIM: 605668) beta-secretase 2 isoform X  (423 aa)
 initn: 1373 init1: 611 opt: 1391  Z-score: 1693.7  bits: 322.7 E(90964): 1.4e-87
Smith-Waterman score: 1391; 48.8% identity (76.4% similar) in 416 aa overlap (86-500:8-417)

          60        70        80        90       100       110     
pF1KE1 RRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQR
                                     . :.::::::::::::...:: ..  :.. 
XP_016                        MAALHLYKKLQILVDTGSSNFAVAGTPHSYIDTYFDT
                                      10        20        30       

         120       130       140       150       160       170     
pF1KE1 QLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSN
       . :::::.    : : ::::.: : .: :::.::.: :..  .:::.: ::..::. : .
XP_016 ERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIK
        40        50        60        70        80        90       

         180       190       200       210       220       230     
pF1KE1 WEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSM
       :.:::::::: .:.:..::: :::::: :...::.::.:.::::.:.  :   .. :::.
XP_016 WNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGS---GTNGGSL
       100       110       120       130       140          150    

         240       250       260       270       280       290     
pF1KE1 IIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNL
       ..:::. ::: :..:::::..::::.. :...::.::.:..::.::: ::.::::::: :
XP_016 VLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLL
          160       170       180       190       200       210    

         300       310       320       330       340       350     
pF1KE1 RLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQ
       :::.:::.:.:...  ::   .: :::: : ::.::  . :::. :: ::.::  : ...
XP_016 RLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSR
          220       230       240       250       260       270    

         360       370       380       390       400       410     
pF1KE1 SFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGF
       ::::::::: :..:.  .. . . ::.:.:: :... :.::..::::::.::::.::.::
XP_016 SFRITILPQLYIQPMMGAGLNYE-CYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGF
          280       290        300       310       320       330   

         420       430       440       450       460        470    
pF1KE1 AVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAIC-ALFMLPLC
       :.: :       .. . ::: : :. .      . .:  :  ..:.. ..: :.... . 
XP_016 AASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIV
           340       350       360       370       380       390   

          480       490       500      
pF1KE1 LMVCQWRCLRCLRQQHDDFADDISLLK     
       :..  .:: :  : .  . ..: : :      
XP_016 LLLLPFRCQR--RPRDPEVVNDESSLVRHRWK
           400         410       420   

>>NP_620477 (OMIM: 605668) beta-secretase 2 isoform B pr  (396 aa)
 initn: 1247 init1: 668 opt: 1249  Z-score: 1521.1  bits: 290.6 E(90964): 5.8e-78
Smith-Waterman score: 1249; 56.4% identity (82.1% similar) in 312 aa overlap (54-365:71-379)

            30        40        50        60        70        80   
pF1KE1 HGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGS
                                     :.  ..:. :::::.: ::.:::.:: .:.
NP_620 RVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGT
               50        60        70        80        90       100

            90       100       110       120       130       140   
pF1KE1 PPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGT
       ::: :.::::::::::::...:: ..  :.. . :::::.    : : ::::.: : .: 
NP_620 PPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGE
              110       120       130       140       150       160

           150       160       170       180       190       200   
pF1KE1 DLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVK
       :::.::.: :..  .:::.: ::..::. : .:.:::::::: .:.:..::: :::::: 
NP_620 DLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVT
              170       180       190       200       210       220

           210       220       230       240       250       260   
pF1KE1 QTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVI
       :...::.::.:.::::.:.  :   .. :::...:::. ::: :..:::::..::::.. 
NP_620 QANIPNVFSMQMCGAGLPVAGS---GTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIE
              230       240          250       260       270       

           270       280       290       300       310       320   
pF1KE1 IVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFW
       :...::.::.:..::.::: ::.::::::: ::::.:::.:.:...  ::   .: ::::
NP_620 ILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFW
       280       290       300       310       320       330       

           330       340       350       360       370       380   
pF1KE1 LGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKF
        : ::.::  . :::. :: ::.::  : ...:::::::::.                  
NP_620 TGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQKLQVLQCLKFPGLSQQRM 
       340       350       360       370       380       390       

           390       400       410       420       430       440   
pF1KE1 AISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDC

>>NP_620476 (OMIM: 605668) beta-secretase 2 isoform C pr  (468 aa)
 initn: 1276 init1: 668 opt: 1041  Z-score: 1266.7  bits: 243.8 E(90964): 8.6e-64
Smith-Waterman score: 1209; 43.3% identity (69.2% similar) in 448 aa overlap (54-500:71-462)

            30        40        50        60        70        80   
pF1KE1 HGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGS
                                     :.  ..:. :::::.: ::.:::.:: .:.
NP_620 RVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGT
               50        60        70        80        90       100

            90       100       110       120       130       140   
pF1KE1 PPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGT
       ::: :.::::::::::::...:: ..  :.. . :::::.    : : ::::.: : .: 
NP_620 PPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGE
              110       120       130       140       150       160

           150       160       170       180       190       200   
pF1KE1 DLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVK
       :::.::.: :..  .:::.: ::..::. : .:.:::::::: .:.:..::: :::::: 
NP_620 DLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVT
              170       180       190       200       210       220

           210       220       230       240       250       260   
pF1KE1 QTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVI
       :...::.::.:.::::.:.  :   .. :::...:::. ::: :..:::::..::::.. 
NP_620 QANIPNVFSMQMCGAGLPVAGS---GTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIE
              230       240          250       260       270       

           270       280       290       300       310       320   
pF1KE1 IVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFW
       :...::.::.:..::.::: ::.::::::: ::::.:::.:.:...  ::          
NP_620 ILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARAS----------
       280       290       300       310       320                 

           330       340       350       360       370       380   
pF1KE1 LGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKF
                               :.                :..:.  .. . . ::.:
NP_620 ------------------------LL----------------YIQPMMGAGLNYE-CYRF
                                               330       340       

           390       400       410       420       430       440   
pF1KE1 AISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDC
       .:: :... :.::..::::::.::::.::.:::.: :       .. . ::: : :. . 
NP_620 GISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASN
        350       360       370       380       390       400      

           450       460        470       480       490       500  
pF1KE1 GYNIPQTDESTLMTIAYVMAAIC-ALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK 
            . .:  :  ..:.. ..: :.... . :..  .:: :  : .  . ..: : :  
NP_620 CVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQR--RPRDPEVVNDESSLVR
        410       420       430       440         450       460    

NP_620 HRWK
           




501 residues in 1 query   sequences
64440809 residues in 90964 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sun Apr 22 20:29:06 2018 done: Sun Apr 22 20:29:07 2018
 Total Scan time:  4.320 Total Display time:  0.110

Function used was FASTA [36.3.4 Apr, 2011]
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