Result of FASTA (omim) for pF1KE0250
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE0250, 196 aa
  1>>>pF1KE0250 196 - 196 aa - 196 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.6379+/-0.00036; mu= 12.2984+/- 0.023
 mean_var=98.5741+/-19.435, 0's: 0 Z-trim(116.1): 152  B-trim: 50 in 2/52
 Lambda= 0.129179
 statistics sampled from 26799 (27092) to 26799 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.695), E-opt: 0.2 (0.318), width:  16
 Scan time:  5.410

The best scores are:                                      opt bits E(85289)
NP_009167 (OMIM: 606988) calcineurin B homologous  ( 195)  806 160.1 2.1e-39
XP_016877368 (OMIM: 606988) PREDICTED: calcineurin ( 123)  431 90.0 1.6e-18
NP_000936 (OMIM: 601302) calcineurin subunit B typ ( 170)  270 60.1 2.2e-09
XP_016875021 (OMIM: 611585) PREDICTED: calcineurin ( 251)  259 58.2 1.2e-08
NP_671709 (OMIM: 613821) calcineurin subunit B typ ( 173)  250 56.4   3e-08
NP_060369 (OMIM: 611585) calcineurin B homologous  ( 214)  244 55.4 7.6e-08
XP_011536805 (OMIM: 611585) PREDICTED: calcineurin ( 202)  222 51.3 1.2e-06
XP_016875022 (OMIM: 611585) PREDICTED: calcineurin ( 216)  219 50.7 1.9e-06
NP_006374 (OMIM: 605564,609439,614869) calcium and ( 187)  182 43.8 0.00021
NP_001122298 (OMIM: 603315) neuronal calcium senso ( 172)  180 43.4 0.00025
NP_055101 (OMIM: 603315) neuronal calcium sensor 1 ( 190)  180 43.4 0.00027
XP_005254183 (OMIM: 605564,609439,614869) PREDICTE ( 210)  176 42.7 0.00049
NP_004267 (OMIM: 605563) calcium-binding protein 1 ( 167)  172 41.9 0.00069
NP_001258818 (OMIM: 605564,609439,614869) calcium  ( 138)  166 40.7  0.0013
NP_001258817 (OMIM: 605564,609439,614869) calcium  ( 144)  166 40.7  0.0014
XP_006720437 (OMIM: 605564,609439,614869) PREDICTE ( 144)  166 40.7  0.0014
NP_001161797 (OMIM: 611585) calcineurin B homologo ( 187)  167 41.0  0.0014
NP_001288153 (OMIM: 605564,609439,614869) calcium  ( 192)  166 40.8  0.0017
NP_775285 (OMIM: 604661) Kv channel-interacting pr ( 227)  166 40.9  0.0019
NP_112482 (OMIM: 605563) calcium-binding protein 1 ( 227)  165 40.7  0.0021
NP_001028849 (OMIM: 605563) calcium-binding protei ( 370)  166 41.1  0.0027
XP_011519463 (OMIM: 605564,609439,614869) PREDICTE ( 167)  160 39.6  0.0033
XP_011512189 (OMIM: 608182) PREDICTED: Kv channel- ( 195)  157 39.1  0.0054
XP_011512191 (OMIM: 608182) PREDICTED: Kv channel- ( 195)  157 39.1  0.0054
XP_011512188 (OMIM: 608182) PREDICTED: Kv channel- ( 223)  157 39.2  0.0059
XP_011512187 (OMIM: 608182) PREDICTED: Kv channel- ( 232)  157 39.2  0.0061
XP_011512186 (OMIM: 608182) PREDICTED: Kv channel- ( 236)  157 39.2  0.0062
XP_011512185 (OMIM: 608182) PREDICTED: Kv channel- ( 240)  157 39.2  0.0063
XP_016875728 (OMIM: 605563) PREDICTED: calcium-bin ( 202)  156 39.0  0.0063
XP_011512184 (OMIM: 608182) PREDICTED: Kv channel- ( 257)  157 39.2  0.0066
XP_016858819 (OMIM: 610646) PREDICTED: calcium and ( 140)  151 37.9  0.0092


>>NP_009167 (OMIM: 606988) calcineurin B homologous prot  (195 aa)
 initn: 796 init1: 454 opt: 806  Z-score: 828.4  bits: 160.1 E(85289): 2.1e-39
Smith-Waterman score: 806; 61.0% identity (87.2% similar) in 195 aa overlap (1-195:1-194)

               10        20        30        40        50        60
pF1KE0 MGSRSSHAAVIPDGDSIRRETGFSQASLLRLHHRFRALDRNKKGYLSRMDLQQIGALAVN
       ::::.:      . . :..:::::.... ::. :: .::....: ::: :.:.:  ::.:
NP_009 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAIN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 PLGDRIIESFFPDGSQRVDFPGFVRVLAHFRPVEDEDTETQDPKKPEPLNSRRNKLHYAF
       :::::::..:::.: ..:.: ::.:.::::::.::.. ...: . ::::::: ::::.::
NP_009 PLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNE-KSKDVNGPEPLNSRSNKLHFAF
               70        80        90        100       110         

              130       140       150       160       170       180
pF1KE0 QLYDLDRDGKISRHEMLQVLRLMVGVQVTEEQLENIADRTVQEADEDGDGAVSFVEFTKS
       .:::::.: :::: :.:::::.::::....::: .:::::.::::.:::.:.::.::.: 
NP_009 RLYDLDKDEKISRDELLQVLRMMVGVNISDEQLGSIADRTIQEADQDGDSAISFTEFVKV
     120       130       140       150       160       170         

              190      
pF1KE0 LEKMDVEQKMSIRILK
       :::.:::::::::.: 
NP_009 LEKVDVEQKMSIRFLH
     180       190     

>>XP_016877368 (OMIM: 606988) PREDICTED: calcineurin B h  (123 aa)
 initn: 419 init1: 356 opt: 431  Z-score: 453.3  bits: 90.0 E(85289): 1.6e-18
Smith-Waterman score: 431; 52.0% identity (79.7% similar) in 123 aa overlap (1-123:1-122)

               10        20        30        40        50        60
pF1KE0 MGSRSSHAAVIPDGDSIRRETGFSQASLLRLHHRFRALDRNKKGYLSRMDLQQIGALAVN
       ::::.:      . . :..:::::.... ::. :: .::....: ::: :.:.:  ::.:
XP_016 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAIN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 PLGDRIIESFFPDGSQRVDFPGFVRVLAHFRPVEDEDTETQDPKKPEPLNSRRNKLHYAF
       :::::::..:::.: ..:.: ::.:.::::::.::.. ...: . ::::::: ::::   
XP_016 PLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNE-KSKDVNGPEPLNSRSNKLHLEE
               70        80        90        100       110         

              130       140       150       160       170       180
pF1KE0 QLYDLDRDGKISRHEMLQVLRLMVGVQVTEEQLENIADRTVQEADEDGDGAVSFVEFTKS
       . :                                                         
XP_016 ERYI                                                        
     120                                                           

>>NP_000936 (OMIM: 601302) calcineurin subunit B type 1   (170 aa)
 initn: 414 init1: 267 opt: 270  Z-score: 289.3  bits: 60.1 E(85289): 2.2e-09
Smith-Waterman score: 368; 35.5% identity (66.3% similar) in 172 aa overlap (23-194:15-170)

               10        20        30        40        50        60
pF1KE0 MGSRSSHAAVIPDGDSIRRETGFSQASLLRLHHRFRALDRNKKGYLSRMDLQQIGALAVN
                             :.   . :: .::. :: ...: ::  .....  :  :
NP_000         MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQN
                       10        20        30        40        50  

               70        80        90       100       110       120
pF1KE0 PLGDRIIESFFPDGSQRVDFPGFVRVLAHFRPVEDEDTETQDPKKPEPLNSRRNKLHYAF
       :: .:.:. :  ::. .:::  :.. ...:    :..                .::..::
NP_000 PLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKE----------------QKLRFAF
             60        70        80                        90      

              130       140       150       160       170       180
pF1KE0 QLYDLDRDGKISRHEMLQVLRLMVGVQVTEEQLENIADRTVQEADEDGDGAVSFVEFTKS
       ..::.:.:: ::  :..:::..::: .. . ::..:.:.:. .::.:::: .:: ::   
NP_000 RIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAV
        100       110       120       130       140       150      

              190      
pF1KE0 LEKMDVEQKMSIRILK
       .  .:...:: . .  
NP_000 VGGLDIHKKMVVDV  
        160       170  

>>XP_016875021 (OMIM: 611585) PREDICTED: calcineurin B h  (251 aa)
 initn: 226 init1:  93 opt: 259  Z-score: 276.0  bits: 58.2 E(85289): 1.2e-08
Smith-Waterman score: 259; 29.4% identity (66.3% similar) in 187 aa overlap (20-195:70-242)

                          10        20        30        40         
pF1KE0            MGSRSSHAAVIPDGDSIRRETGFSQASLLRLHHRFRALDRNKKGYLSRM
                                     .::::. .. .::.::. :. ..   . . 
XP_016 PERDARPGAPAAGTMGAAHSASEEVRELEGKTGFSSDQIEQLHRRFKQLSGDQPT-IRKE
      40        50        60        70        80        90         

      50        60        70                 80        90       100
pF1KE0 DLQQIGALAVNPLGDRIIESFF--------PDG-SQRVDFPGFVRVLAHFRPVEDEDTET
       .....  : .::. ..:...::        :.: .....:  :. ....:::.   :: :
XP_016 NFNNVPDLELNPIRSKIVRAFFDNRNLRKGPSGLADEINFEDFLTIMSYFRPI---DT-T
      100       110       120       130       140       150        

              110       120       130       140         150        
pF1KE0 QDPKKPEPLNSRRNKLHYAFQLYDLDRDGKISRHEMLQVLR-LMVGV-QVTEEQLENIAD
       .: .. :   ::..::.. :..:: : ::.:. .:. .:.. :. :  .. .:. ..:::
XP_016 MDEEQVE--LSRKEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIEKESARSIAD
          160         170       180       190       200       210  

      160       170       180       190              
pF1KE0 RTVQEADEDGDGAVSFVEFTKSLEKMDVEQKMSIRILK        
        ...::     : . .       . .:.: :: .:.:         
XP_016 GAMMEAASVCMGQMIW-------QGIDIETKMHVRFLNMETMALCH
            220              230       240       250 

>>NP_671709 (OMIM: 613821) calcineurin subunit B type 2   (173 aa)
 initn: 430 init1: 250 opt: 250  Z-score: 269.1  bits: 56.4 E(85289): 3e-08
Smith-Waterman score: 354; 35.7% identity (66.1% similar) in 168 aa overlap (23-190:18-169)

               10        20        30        40        50        60
pF1KE0 MGSRSSHAAVIPDGDSIRRETGFSQASLLRLHHRFRALDRNKKGYLSRMDLQQIGALAVN
                             :..  . :: .::. :: .:.: ::  .....  :  :
NP_671      MSTMGNEASYPAEMCSHFDNDEIKRLGRRFKKLDLDKSGSLSVEEFMSLPELRHN
                    10        20        30        40        50     

               70        80        90       100       110       120
pF1KE0 PLGDRIIESFFPDGSQRVDFPGFVRVLAHFRPVEDEDTETQDPKKPEPLNSRRNKLHYAF
       ::  :.:. :  ::. .:::  :.   ..:    ::.                .::..::
NP_671 PLVRRVIDVFDTDGDGEVDFKEFILGTSQFSVKGDEE----------------QKLRFAF
          60        70        80        90                         

              130       140       150       160       170       180
pF1KE0 QLYDLDRDGKISRHEMLQVLRLMVGVQVTEEQLENIADRTVQEADEDGDGAVSFVEFTKS
       ..::.:.:: ::  :..:::..::: ..:. ::....:.:.   :.:::: .:: ::.  
NP_671 SIYDMDKDGYISNGELFQVLKMMVGNNLTDWQLQQLVDKTIIILDKDGDGKISFEEFSAV
     100       110       120       130       140       150         

              190      
pF1KE0 LEKMDVEQKMSIRILK
       .. .....:.      
NP_671 VRDLEIHKKLVLIV  
     160       170     

>>NP_060369 (OMIM: 611585) calcineurin B homologous prot  (214 aa)
 initn: 226 init1:  93 opt: 244  Z-score: 261.8  bits: 55.4 E(85289): 7.6e-08
Smith-Waterman score: 283; 29.9% identity (66.5% similar) in 197 aa overlap (20-195:17-205)

               10        20        30        40        50        60
pF1KE0 MGSRSSHAAVIPDGDSIRRETGFSQASLLRLHHRFRALDRNKKGYLSRMDLQQIGALAVN
                          .::::. .. .::.::. :. ..   . . .....  : .:
NP_060    MGAAHSASEEVRELEGKTGFSSDQIEQLHRRFKQLSGDQPT-IRKENFNNVPDLELN
                  10        20        30        40         50      

               70                 80        90       100       110 
pF1KE0 PLGDRIIESFF--------PDG-SQRVDFPGFVRVLAHFRPVEDEDTETQDPKKPEPLNS
       :. ..:...::        :.: .....:  :. ....:::.   :: :.: .. :   :
NP_060 PIRSKIVRAFFDNRNLRKGPSGLADEINFEDFLTIMSYFRPI---DT-TMDEEQVE--LS
         60        70        80        90          100          110

             120       130       140         150       160         
pF1KE0 RRNKLHYAFQLYDLDRDGKISRHEMLQVLR-LMVGV-QVTEEQLENIADRTVQEA-----
       :..::.. :..:: : ::.:. .:. .:.. :. :  .. .:. ..::: ...::     
NP_060 RKEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIEKESARSIADGAMMEAASVCM
              120       130       140       150       160       170

               170       180       190              
pF1KE0 -----DEDGDGAVSFVEFTKSLEKMDVEQKMSIRILK        
            :.  .: ..: .: :  . .:.: :: .:.:         
NP_060 GQMEPDQVYEG-ITFEDFLKIWQGIDIETKMHVRFLNMETMALCH
              180        190       200       210    

>>XP_011536805 (OMIM: 611585) PREDICTED: calcineurin B h  (202 aa)
 initn: 202 init1:  93 opt: 222  Z-score: 240.0  bits: 51.3 E(85289): 1.2e-06
Smith-Waterman score: 261; 29.0% identity (65.8% similar) in 193 aa overlap (24-195:9-193)

               10        20        30        40        50        60
pF1KE0 MGSRSSHAAVIPDGDSIRRETGFSQASLLRLHHRFRALDRNKKGYLSRMDLQQIGALAVN
                              :. .. .::.::. :. ..   . . .....  : .:
XP_011                MESSQEHVSSDQIEQLHRRFKQLSGDQPT-IRKENFNNVPDLELN
                              10        20         30        40    

               70                 80        90       100       110 
pF1KE0 PLGDRIIESFF--------PDG-SQRVDFPGFVRVLAHFRPVEDEDTETQDPKKPEPLNS
       :. ..:...::        :.: .....:  :. ....:::.   :: :.: .. :   :
XP_011 PIRSKIVRAFFDNRNLRKGPSGLADEINFEDFLTIMSYFRPI---DT-TMDEEQVE--LS
           50        60        70        80            90          

             120       130       140         150       160         
pF1KE0 RRNKLHYAFQLYDLDRDGKISRHEMLQVLR-LMVGV-QVTEEQLENIADRTVQEA-----
       :..::.. :..:: : ::.:. .:. .:.. :. :  .. .:. ..::: ...::     
XP_011 RKEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIEKESARSIADGAMMEAASVCM
      100       110       120       130       140       150        

               170       180       190              
pF1KE0 -----DEDGDGAVSFVEFTKSLEKMDVEQKMSIRILK        
            :.  .: ..: .: :  . .:.: :: .:.:         
XP_011 GQMEPDQVYEG-ITFEDFLKIWQGIDIETKMHVRFLNMETMALCH
      160        170       180       190       200  

>>XP_016875022 (OMIM: 611585) PREDICTED: calcineurin B h  (216 aa)
 initn: 201 init1:  91 opt: 219  Z-score: 236.6  bits: 50.7 E(85289): 1.9e-06
Smith-Waterman score: 219; 31.0% identity (69.8% similar) in 129 aa overlap (20-139:70-191)

                          10        20        30        40         
pF1KE0            MGSRSSHAAVIPDGDSIRRETGFSQASLLRLHHRFRALDRNKKGYLSRM
                                     .::::. .. .::.::. :. ..   . . 
XP_016 PERDARPGAPAAGTMGAAHSASEEVRELEGKTGFSSDQIEQLHRRFKQLSGDQPT-IRKE
      40        50        60        70        80        90         

      50        60        70                 80        90       100
pF1KE0 DLQQIGALAVNPLGDRIIESFF--------PDG-SQRVDFPGFVRVLAHFRPVEDEDTET
       .....  : .::. ..:...::        :.: .....:  :. ....:::.   :: :
XP_016 NFNNVPDLELNPIRSKIVRAFFDNRNLRKGPSGLADEINFEDFLTIMSYFRPI---DT-T
      100       110       120       130       140       150        

              110       120       130       140       150       160
pF1KE0 QDPKKPEPLNSRRNKLHYAFQLYDLDRDGKISRHEMLQVLRLMVGVQVTEEQLENIADRT
       .: .. :   ::..::.. :..:: : ::.:. .:. .:                     
XP_016 MDEEQVE--LSRKEKLRFLFHMYDSDSDGRITLEEYRNVKWSRSCCRETLTSRRSPLAPS
          160         170       180       190       200       210  

              170       180       190      
pF1KE0 VQEADEDGDGAVSFVEFTKSLEKMDVEQKMSIRILK
                                           
XP_016 PTGP                                
                                           

>>NP_006374 (OMIM: 605564,609439,614869) calcium and int  (187 aa)
 initn: 253 init1: 152 opt: 182  Z-score: 200.2  bits: 43.8 E(85289): 0.00021
Smith-Waterman score: 224; 27.9% identity (56.8% similar) in 190 aa overlap (15-194:14-187)

               10        20        30        40              50    
pF1KE0 MGSRSSHAAVIPDGDSIRRETGFSQASLLRLHHRFRALDRN------KKGYLSRMDLQ--
                     :. .  : :.. ..:.:: ::  :  :      .:. . .. ..  
NP_006  MGNKQTIFTEEQLDNYQDCTFFNKKDILKLHSRFYELAPNLVPMDYRKSPIVHVPMSLI
                10        20        30        40        50         

              60        70        80        90       100       110 
pF1KE0 -QIGALAVNPLGDRIIESFFPDGSQRVDFPGFVRVLAHFRPVEDEDTETQDPKKPEPLNS
        :.  :  ::. .::. .:  ::   . :  :: ...    :  :..       :. :  
NP_006 IQMPELRENPFKERIVAAFSEDGEGNLTFNDFVDMFS----VLCESA-------PREL--
      60        70        80        90           100               

             120       130       140       150       160       170 
pF1KE0 RRNKLHYAFQLYDLDRDGKISRHEMLQVLRLMVGVQVTEEQLENIADRTVQEADEDGDGA
          : .:::..::.. :. : ....  .:  ..  .. ::..  . :....::: :::: 
NP_006 ---KANYAFKIYDFNTDNFICKEDLELTLARLTKSELDEEEVVLVCDKVIEEADLDGDGK
           110       120       130       140       150       160   

             180        190      
pF1KE0 VSFVEFTKSLEKM-DVEQKMSIRILK
       ..:..:   . :  :  . . :::  
NP_006 LGFADFEDMIAKAPDFLSTFHIRI  
           170       180         

>>NP_001122298 (OMIM: 603315) neuronal calcium sensor 1   (172 aa)
 initn: 151 init1: 113 opt: 180  Z-score: 198.6  bits: 43.4 E(85289): 0.00025
Smith-Waterman score: 180; 31.5% identity (58.0% similar) in 162 aa overlap (43-192:14-167)

             20        30        40        50        60        70  
pF1KE0 DGDSIRRETGFSQASLLRLHHRFRALDRNKKGYLSRMDLQQIGALAVNPLGDRIIESFFP
                                     ::...     :. : . .    .: ..:::
NP_001                  MATITEKEVQQWYKGFIKDCPSGQLDAAGFQ----KIYKQFFP
                                10        20        30             

             80        90       100       110          120         
pF1KE0 DGSQRVDFPGFVRVLAHFRPVEDEDTETQDPKKPEPLNSR---RNKLHYAFQLYDLDRDG
        :.  . :  :  :.  :   .:   : ..  .   ..::    .::..::.::::: ::
NP_001 FGDP-TKFATF--VFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDG
      40           50        60        70        80        90      

     130          140         150         160       170       180  
pF1KE0 KISRHEMLQV---LRLMVG--VQVTEEQL--ENIADRTVQEADEDGDGAVSFVEFTKSLE
        :.:.:::..   .  :::  :.. ::.   :. .::     :...:: ... :: ..  
NP_001 YITRNEMLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEG-S
        100       110       120       130       140       150      

              190       
pF1KE0 KMD--VEQKMSIRILK 
       : :  . : .:.     
NP_001 KADPSIVQALSLYDGLV
         160       170  




196 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 19:14:18 2016 done: Thu Nov  3 19:14:19 2016
 Total Scan time:  5.410 Total Display time:  0.000

Function used was FASTA [36.3.4 Apr, 2011]
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