Result of FASTA (omim) for pF1KB7274
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB7274, 745 aa
  1>>>pF1KB7274 745 - 745 aa - 745 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 11.6527+/-0.000442; mu= -10.9029+/- 0.028
 mean_var=271.0086+/-57.820, 0's: 0 Z-trim(118.2): 24  B-trim: 565 in 1/57
 Lambda= 0.077908
 statistics sampled from 30899 (30923) to 30899 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.69), E-opt: 0.2 (0.363), width:  16
 Scan time:  8.210

The best scores are:                                      opt bits E(85289)
NP_116021 (OMIM: 605553) poly(A) polymerase alpha  ( 745) 4839 557.8 5.6e-158
NP_001280556 (OMIM: 605553) poly(A) polymerase alp ( 744) 4820 555.7 2.5e-157
XP_005267339 (OMIM: 605553) PREDICTED: poly(A) pol ( 699) 4381 506.3 1.7e-142
XP_005267338 (OMIM: 605553) PREDICTED: poly(A) pol ( 724) 4376 505.8 2.5e-142
XP_016876425 (OMIM: 605553) PREDICTED: poly(A) pol ( 698) 4362 504.2 7.3e-142
XP_016876424 (OMIM: 605553) PREDICTED: poly(A) pol ( 723) 4357 503.7 1.1e-141
NP_064529 (OMIM: 607436) poly(A) polymerase beta [ ( 637) 3527 410.3 1.2e-113
NP_001280561 (OMIM: 605553) poly(A) polymerase alp ( 495) 3187 372.1 3.1e-102
NP_001280557 (OMIM: 605553) poly(A) polymerase alp ( 495) 3187 372.1 3.1e-102
NP_075045 (OMIM: 616865) poly(A) polymerase gamma  ( 736) 2817 330.6 1.4e-89
XP_005264557 (OMIM: 616865) PREDICTED: poly(A) pol ( 714) 2768 325.1 6.4e-88
XP_005264558 (OMIM: 616865) PREDICTED: poly(A) pol ( 692) 2668 313.8 1.5e-84
NP_001238935 (OMIM: 605553) poly(A) polymerase alp ( 285) 1847 221.4   4e-57
XP_011531343 (OMIM: 616865) PREDICTED: poly(A) pol ( 498) 1623 196.3 2.5e-49
XP_016860212 (OMIM: 616865) PREDICTED: poly(A) pol ( 498) 1623 196.3 2.5e-49
XP_016860213 (OMIM: 616865) PREDICTED: poly(A) pol ( 476) 1574 190.8 1.1e-47
NP_001238936 (OMIM: 605553) poly(A) polymerase alp ( 238) 1343 164.7 3.9e-40


>>NP_116021 (OMIM: 605553) poly(A) polymerase alpha isof  (745 aa)
 initn: 4839 init1: 4839 opt: 4839  Z-score: 2957.2  bits: 557.8 E(85289): 5.6e-158
Smith-Waterman score: 4839; 100.0% identity (100.0% similar) in 745 aa overlap (1-745:1-745)

               10        20        30        40        50        60
pF1KB7 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB7 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB7 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB7 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB7 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB7 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB7 ATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 ATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB7 QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB7 PKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAASLLASQKTSSTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 PKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAASLLASQKTSSTD
              670       680       690       700       710       720

              730       740     
pF1KB7 LSDIPALPANPIPVIKNSIKLRLNR
       :::::::::::::::::::::::::
NP_116 LSDIPALPANPIPVIKNSIKLRLNR
              730       740     

>>NP_001280556 (OMIM: 605553) poly(A) polymerase alpha i  (744 aa)
 initn: 3683 init1: 3683 opt: 4820  Z-score: 2945.6  bits: 555.7 E(85289): 2.5e-157
Smith-Waterman score: 4820; 99.9% identity (99.9% similar) in 745 aa overlap (1-745:1-744)

               10        20        30        40        50        60
pF1KB7 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB7 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB7 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB7 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB7 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB7 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB7 ATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
       ::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATKTSPLNSSGSSQG-NSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
              550        560       570       580       590         

              610       620       630       640       650       660
pF1KB7 QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
     600       610       620       630       640       650         

              670       680       690       700       710       720
pF1KB7 PKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAASLLASQKTSSTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAASLLASQKTSSTD
     660       670       680       690       700       710         

              730       740     
pF1KB7 LSDIPALPANPIPVIKNSIKLRLNR
       :::::::::::::::::::::::::
NP_001 LSDIPALPANPIPVIKNSIKLRLNR
     720       730       740    

>>XP_005267339 (OMIM: 605553) PREDICTED: poly(A) polymer  (699 aa)
 initn: 4441 init1: 4381 opt: 4381  Z-score: 2679.4  bits: 506.3 E(85289): 1.7e-142
Smith-Waterman score: 4461; 93.8% identity (93.8% similar) in 745 aa overlap (1-745:1-699)

               10        20        30        40        50        60
pF1KB7 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB7 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB7 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB7 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB7 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB7 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB7 ATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB7 QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB7 PKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAASLLASQKTSSTD
       ::::::::                                              ::::::
XP_005 PKKTKTEE----------------------------------------------KTSSTD
                                                            670    

              730       740     
pF1KB7 LSDIPALPANPIPVIKNSIKLRLNR
       :::::::::::::::::::::::::
XP_005 LSDIPALPANPIPVIKNSIKLRLNR
          680       690         

>>XP_005267338 (OMIM: 605553) PREDICTED: poly(A) polymer  (724 aa)
 initn: 4374 init1: 4374 opt: 4376  Z-score: 2676.1  bits: 505.8 E(85289): 2.5e-142
Smith-Waterman score: 4650; 97.2% identity (97.2% similar) in 745 aa overlap (1-745:1-724)

               10        20        30        40        50        60
pF1KB7 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB7 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB7 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB7 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB7 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB7 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB7 ATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB7 QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB7 PKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAASLLASQKTSSTD
       ::::::::                     :::::::::::::::::::::::::::::::
XP_005 PKKTKTEE---------------------EQLDTETSTTQSETIQTAASLLASQKTSSTD
                                   670       680       690         

              730       740     
pF1KB7 LSDIPALPANPIPVIKNSIKLRLNR
       :::::::::::::::::::::::::
XP_005 LSDIPALPANPIPVIKNSIKLRLNR
     700       710       720    

>>XP_016876425 (OMIM: 605553) PREDICTED: poly(A) polymer  (698 aa)
 initn: 3690 init1: 3690 opt: 4362  Z-score: 2667.9  bits: 504.2 E(85289): 7.3e-142
Smith-Waterman score: 4442; 93.7% identity (93.7% similar) in 745 aa overlap (1-745:1-698)

               10        20        30        40        50        60
pF1KB7 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB7 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB7 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB7 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB7 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB7 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB7 ATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
       ::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATKTSPLNSSGSSQG-NSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
              550        560       570       580       590         

              610       620       630       640       650       660
pF1KB7 QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
     600       610       620       630       640       650         

              670       680       690       700       710       720
pF1KB7 PKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAASLLASQKTSSTD
       ::::::::                                              ::::::
XP_016 PKKTKTEE----------------------------------------------KTSSTD
     660                                                     670   

              730       740     
pF1KB7 LSDIPALPANPIPVIKNSIKLRLNR
       :::::::::::::::::::::::::
XP_016 LSDIPALPANPIPVIKNSIKLRLNR
           680       690        

>>XP_016876424 (OMIM: 605553) PREDICTED: poly(A) polymer  (723 aa)
 initn: 3692 init1: 3692 opt: 4357  Z-score: 2664.6  bits: 503.7 E(85289): 1.1e-141
Smith-Waterman score: 4631; 97.0% identity (97.0% similar) in 745 aa overlap (1-745:1-723)

               10        20        30        40        50        60
pF1KB7 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB7 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB7 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB7 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB7 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB7 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB7 ATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
       ::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATKTSPLNSSGSSQG-NSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
              550        560       570       580       590         

              610       620       630       640       650       660
pF1KB7 QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
     600       610       620       630       640       650         

              670       680       690       700       710       720
pF1KB7 PKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAASLLASQKTSSTD
       ::::::::                     :::::::::::::::::::::::::::::::
XP_016 PKKTKTEE---------------------EQLDTETSTTQSETIQTAASLLASQKTSSTD
     660                            670       680       690        

              730       740     
pF1KB7 LSDIPALPANPIPVIKNSIKLRLNR
       :::::::::::::::::::::::::
XP_016 LSDIPALPANPIPVIKNSIKLRLNR
      700       710       720   

>>NP_064529 (OMIM: 607436) poly(A) polymerase beta [Homo  (637 aa)
 initn: 3533 init1: 3253 opt: 3527  Z-score: 2161.3  bits: 410.3 E(85289): 1.2e-113
Smith-Waterman score: 3527; 86.1% identity (93.6% similar) in 625 aa overlap (1-625:2-624)

                10        20        30        40        50         
pF1KB7  MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQ
        :::::::::  :  :: ..::..::::::.::::::.:::.:::::.::::::::::::
NP_064 MMPFPVTTQGPPQPAPPPNRYGVSSPISLAVPKETDCLLTQRLIETLRPFGVFEEEEELQ
               10        20        30        40        50        60

      60        70        80        90       100       110         
pF1KB7 RRILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCV
       ::::.: :::::::::::::::::.:::::::::::::::::::::::::::::::::::
NP_064 RRILVLEKLNNLVKEWIREISESKSLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCV
               70        80        90       100       110       120

     120       130       140       150       160       170         
pF1KB7 APRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIP
       :: :::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
NP_064 APSHVDRSDFFTSFYAKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIP
              130       140       150       160       170       180

     180       190       200       210       220       230         
pF1KB7 EDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::
NP_064 EDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKCHNIYSN
              190       200       210       220       230       240

     240       250       260       270       280       290         
pF1KB7 ILGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPV
       ::::::::::::::::::::::::.:::::.:::::::.::::::::::.::: ::::::
NP_064 ILGFLGGVSWAMLVARTCQLYPNAVASTLVRKFFLVFSEWEWPNPVLLKEPEERNLNLPV
              250       260       270       280       290       300

     300       310       320       330       340       350         
pF1KB7 WDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWS
       :::::::::::::::::::::::::::::::.::::::.:::::::::: ::::::::::
NP_064 WDPRVNPSDRYHLMPIITPAYPQQNSTYNVSISTRMVMIEEFKQGLAITHEILLSKAEWS
              310       320       330       340       350       360

     360       370       380       390       400       410         
pF1KB7 KLFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQ
       ::::::.::::::::::::::: ::::.::::::::::::::::::::::::::::::::
NP_064 KLFEAPSFFQKYKHYIVLLASASTEKQHLEWVGLVESKIRILVGSLEKNEFITLAHVNPQ
              370       380       390       400       410       420

     420       430       440       450       460       470         
pF1KB7 SFPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEV
       :::::::::: ::::::::::: .:: .::: ::.:::::::::::::::::.::::::.
NP_064 SFPAPKENPDMEEFRTMWVIGLGLKKPDNSEILSIDLTYDIQSFTDTVYRQAVNSKMFEM
              430       440       450       460       470       480

     480       490       500       510       520       530         
pF1KB7 DMKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPT
        :::.:::..::.::::::.:::: :: ::::: .:: :::::.:::   .::::::: :
NP_064 GMKITAMHLRRKELHQLLPHHVLQDKKAHSTEGRRLTDLNDSSFDLSAGCENSMSVPSST
              490       500       510       520       530       540

     540       550       560       570       580       590         
pF1KB7 SATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTA
       :. ::.:: ::  :::::::: :: .:::.:::::: :. :::..:::: . .::::...
NP_064 STMKTGPLISS--SQGRNSPALAVMTASVANIQATEFSLQQVNTNESSGVALNESIPHAV
              550         560       570       580       590        

     600       610       620       630       640       650         
pF1KB7 TQPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEE
       .:::::: ::  :.:::::: :.. :                                  
NP_064 SQPAISPSPKAMVARVVSSTCLISHPDLQETQQQTYLIL                     
      600       610       620       630                            

>>NP_001280561 (OMIM: 605553) poly(A) polymerase alpha i  (495 aa)
 initn: 3187 init1: 3187 opt: 3187  Z-score: 1956.5  bits: 372.1 E(85289): 3.1e-102
Smith-Waterman score: 3187; 100.0% identity (100.0% similar) in 495 aa overlap (251-745:1-495)

              230       240       250       260       270       280
pF1KB7 RLTLRAIKLWAKRHNIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWE
                                     ::::::::::::::::::::::::::::::
NP_001                               MLVARTCQLYPNAIASTLVHKFFLVFSKWE
                                             10        20        30

              290       300       310       320       330       340
pF1KB7 WPNPVLLKQPEECNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WPNPVLLKQPEECNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEE
               40        50        60        70        80        90

              350       360       370       380       390       400
pF1KB7 FKQGLAITDEILLSKAEWSKLFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKQGLAITDEILLSKAEWSKLFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRI
              100       110       120       130       140       150

              410       420       430       440       450       460
pF1KB7 LVGSLEKNEFITLAHVNPQSFPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVGSLEKNEFITLAHVNPQSFPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDI
              160       170       180       190       200       210

              470       480       490       500       510       520
pF1KB7 QSFTDTVYRQAINSKMFEVDMKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALND
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSFTDTVYRQAINSKMFEVDMKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALND
              220       230       240       250       260       270

              530       540       550       560       570       580
pF1KB7 SSLDLSMDSDNSMSVPSPTSATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSLDLSMDSDNSMSVPSPTSATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQ
              280       290       300       310       320       330

              590       600       610       620       630       640
pF1KB7 VNSSESSGGTSSESIPQTATQPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNSSESSGGTSSESIPQTATQPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAAT
              340       350       360       370       380       390

              650       660       670       680       690       700
pF1KB7 KIPTPIVGVKRTSSPHKEESPKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIPTPIVGVKRTSSPHKEESPKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQ
              400       410       420       430       440       450

              710       720       730       740     
pF1KB7 SETIQTAASLLASQKTSSTDLSDIPALPANPIPVIKNSIKLRLNR
       :::::::::::::::::::::::::::::::::::::::::::::
NP_001 SETIQTAASLLASQKTSSTDLSDIPALPANPIPVIKNSIKLRLNR
              460       470       480       490     

>>NP_001280557 (OMIM: 605553) poly(A) polymerase alpha i  (495 aa)
 initn: 3187 init1: 3187 opt: 3187  Z-score: 1956.5  bits: 372.1 E(85289): 3.1e-102
Smith-Waterman score: 3187; 100.0% identity (100.0% similar) in 495 aa overlap (251-745:1-495)

              230       240       250       260       270       280
pF1KB7 RLTLRAIKLWAKRHNIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWE
                                     ::::::::::::::::::::::::::::::
NP_001                               MLVARTCQLYPNAIASTLVHKFFLVFSKWE
                                             10        20        30

              290       300       310       320       330       340
pF1KB7 WPNPVLLKQPEECNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WPNPVLLKQPEECNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEE
               40        50        60        70        80        90

              350       360       370       380       390       400
pF1KB7 FKQGLAITDEILLSKAEWSKLFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKQGLAITDEILLSKAEWSKLFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRI
              100       110       120       130       140       150

              410       420       430       440       450       460
pF1KB7 LVGSLEKNEFITLAHVNPQSFPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVGSLEKNEFITLAHVNPQSFPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDI
              160       170       180       190       200       210

              470       480       490       500       510       520
pF1KB7 QSFTDTVYRQAINSKMFEVDMKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALND
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSFTDTVYRQAINSKMFEVDMKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALND
              220       230       240       250       260       270

              530       540       550       560       570       580
pF1KB7 SSLDLSMDSDNSMSVPSPTSATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSLDLSMDSDNSMSVPSPTSATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQ
              280       290       300       310       320       330

              590       600       610       620       630       640
pF1KB7 VNSSESSGGTSSESIPQTATQPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNSSESSGGTSSESIPQTATQPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAAT
              340       350       360       370       380       390

              650       660       670       680       690       700
pF1KB7 KIPTPIVGVKRTSSPHKEESPKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIPTPIVGVKRTSSPHKEESPKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQ
              400       410       420       430       440       450

              710       720       730       740     
pF1KB7 SETIQTAASLLASQKTSSTDLSDIPALPANPIPVIKNSIKLRLNR
       :::::::::::::::::::::::::::::::::::::::::::::
NP_001 SETIQTAASLLASQKTSSTDLSDIPALPANPIPVIKNSIKLRLNR
              460       470       480       490     

>>NP_075045 (OMIM: 616865) poly(A) polymerase gamma [Hom  (736 aa)
 initn: 2784 init1: 2669 opt: 2817  Z-score: 1729.0  bits: 330.6 E(85289): 1.4e-89
Smith-Waterman score: 2844; 61.2% identity (78.8% similar) in 747 aa overlap (13-745:12-736)

               10        20        30        40        50        60
pF1KB7 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
                   .:  :::::::::::::.::: : . :::::...:::::::.::::..
NP_075  MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNH
                10        20        30        40        50         

               70        80        90       100       110       120
pF1KB7 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
       :...:::::::::::: ..::::::: ::. .::::::::::::::::::::::::::::
NP_075 RLVVLGKLNNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVA
      60        70        80        90       100       110         

              130       140       150       160       170       180
pF1KB7 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
       ::::.::::: ::..::: :. ...:::::.:::::::. :::::::..:::::.::: .
NP_075 PRHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISD
     120       130       140       150       160       170         

              190       200       210       220       230       240
pF1KB7 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
       .::::::: :..:::::::::::::::::::::::: ..:::::::.::::::..::::.
NP_075 NLDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNM
     180       190       200       210       220       230         

              250       260       270       280       290       300
pF1KB7 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
       ::::::::::::::::::::::: :::::::::::::::::::::::::::: :::::::
NP_075 LGFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVW
     240       250       260       270       280       290         

              310       320       330       340       350       360
pF1KB7 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
       ::::::::::::::::::::::::::::::.::: :::::::::::.::::: .:..:::
NP_075 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSK
     300       310       320       330       340       350         

              370       380       390       400       410       420
pF1KB7 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
       :.: :::::::.::::: ::: ::...::::::::::::.:::.::.:::::::::::::
NP_075 LLEPPNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQS
     360       370       380       390       400       410         

              430       440       450       460       470       480
pF1KB7 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
       ::. ::.   ... .:: .:..:...::.:....::::::::::::::::: : .:..  
NP_075 FPGNKEHHKDNNYVSMWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEG
     420       430       440       450       460       470         

              490       500       510                520       530 
pF1KB7 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGV---------KLTALNDSSLDLSMDSDN
       ::: : :::.::::. :: ..::::::.:   :         :  .:..: :: : :.::
NP_075 MKIEATHVKKKQLHHYLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDN
     480       490       500       510       520       530         

             540       550         560       570       580         
pF1KB7 SMSVPSPTSATKTSPLNSSGSSQGRNS--PAPAVTAASVTNIQATEVSVPQVNSSESSGG
       .    ::.: .  ::  : : .. :::  :: ...   ..   :  .:.: .       :
NP_075 GTPFNSPASKSD-SP--SVGETE-RNSAEPAAVIVEKPLSVPPAQGLSIPVI-------G
     540       550           560       570       580               

     590       600       610       620       630        640        
pF1KB7 TSSESIPQTATQPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSG-NAATKIPTPIVG
       .. .:  .:.. :..   :  .:.: :   :...:   ..:.   .: .  ::  ::   
NP_075 AKVDSTVKTVSPPTVCTIPT-VVGRNVIP-RITTPHNPAQGQPHLNGMSNITKTVTP---
      590       600        610        620       630       640      

      650       660       670       680       690       700        
pF1KB7 VKRTSSPHKEESPKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAA
        ::. ::  . .::. :  :         :  . .:   :.:.    ...  .:..   .
NP_075 -KRSHSPSIDGTPKRLKDVEKFIR-----LESTFKDPRTAEERKRKSVDAIGGESMPIPT
            650       660            670       680       690       

      710        720        730       740     
pF1KB7 SLLASQKT-SSTDLSDIPA-LPANPIPVIKNSIKLRLNR
          . .:   : .: :  . .::: : ::::::.: :::
NP_075 IDTSRKKRLPSKELPDSSSPVPANNIRVIKNSIRLTLNR
       700       710       720       730      




745 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 22:12:56 2016 done: Sat Nov  5 22:12:57 2016
 Total Scan time:  8.210 Total Display time:  0.170

Function used was FASTA [36.3.4 Apr, 2011]
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