Result of FASTA (omim) for pF1KB5561
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB5561, 497 aa
  1>>>pF1KB5561 497 - 497 aa - 497 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.9993+/-0.000361; mu= 11.5558+/- 0.023
 mean_var=139.6684+/-28.186, 0's: 0 Z-trim(117.7): 42  B-trim: 216 in 1/51
 Lambda= 0.108524
 statistics sampled from 29912 (29955) to 29912 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.705), E-opt: 0.2 (0.351), width:  16
 Scan time: 10.850

The best scores are:                                      opt bits E(85289)
NP_002383 (OMIM: 164785,614401) E3 ubiquitin-prote ( 497) 3326 532.4 1.1e-150
XP_005268929 (OMIM: 164785,614401) PREDICTED: E3 u ( 491) 3288 526.4  7e-149
XP_006719462 (OMIM: 164785,614401) PREDICTED: E3 u ( 430) 2900 465.6 1.2e-130
XP_006719463 (OMIM: 164785,614401) PREDICTED: E3 u ( 390) 2629 423.2 6.8e-118
NP_001138811 (OMIM: 164785,614401) E3 ubiquitin-pr ( 442) 2212 357.9 3.4e-98
NP_001265391 (OMIM: 164785,614401) E3 ubiquitin-pr ( 321) 1853 301.6 2.2e-81
NP_001138809 (OMIM: 164785,614401) E3 ubiquitin-pr ( 444) 1524 250.2   9e-66
NP_001138812 (OMIM: 164785,614401) E3 ubiquitin-pr ( 295) 1373 226.4 8.6e-59
NP_002384 (OMIM: 602704) protein Mdm4 isoform 1 [H ( 490)  886 150.4 1.1e-35
XP_016856800 (OMIM: 602704) PREDICTED: protein Mdm ( 508)  886 150.4 1.2e-35
XP_016856801 (OMIM: 602704) PREDICTED: protein Mdm ( 503)  876 148.8 3.4e-35
NP_001265446 (OMIM: 602704) protein Mdm4 isoform 5 ( 392)  594 104.6 5.5e-22
NP_001265448 (OMIM: 602704) protein Mdm4 isoform 7 ( 267)  487 87.7 4.6e-17
NP_001191100 (OMIM: 602704) protein Mdm4 isoform 2 ( 440)  369 69.4 2.4e-11
XP_016856802 (OMIM: 602704) PREDICTED: protein Mdm ( 458)  369 69.4 2.5e-11
NP_001191101 (OMIM: 602704) protein Mdm4 isoform 3 ( 164)  345 65.3 1.6e-10
NP_001265447 (OMIM: 602704) protein Mdm4 isoform 6 ( 116)  329 62.6 6.8e-10
NP_001265445 (OMIM: 602704) protein Mdm4 isoform 4 ( 140)  323 61.8 1.5e-09


>>NP_002383 (OMIM: 164785,614401) E3 ubiquitin-protein l  (497 aa)
 initn: 3326 init1: 3326 opt: 3326  Z-score: 2825.9  bits: 532.4 E(85289): 1.1e-150
Smith-Waterman score: 3326; 100.0% identity (100.0% similar) in 497 aa overlap (1-497:1-497)

               10        20        30        40        50        60
pF1KB5 MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 FYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 SSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 LSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGD
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 WLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 WLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEED
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 PEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAE
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB5 EGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEF
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB5 EREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKP
              430       440       450       460       470       480

              490       
pF1KB5 CPVCRQPIQMIVLTYFP
       :::::::::::::::::
NP_002 CPVCRQPIQMIVLTYFP
              490       

>>XP_005268929 (OMIM: 164785,614401) PREDICTED: E3 ubiqu  (491 aa)
 initn: 3288 init1: 3288 opt: 3288  Z-score: 2793.8  bits: 526.4 E(85289): 7e-149
Smith-Waterman score: 3288; 100.0% identity (100.0% similar) in 491 aa overlap (7-497:1-491)

               10        20        30        40        50        60
pF1KB5 MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVL
             ::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005       MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVL
                     10        20        30        40        50    

               70        80        90       100       110       120
pF1KB5 FYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE
           60        70        80        90       100       110    

              130       140       150       160       170       180
pF1KB5 SSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDE
          120       130       140       150       160       170    

              190       200       210       220       230       240
pF1KB5 LSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGD
          180       190       200       210       220       230    

              250       260       270       280       290       300
pF1KB5 WLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEED
          240       250       260       270       280       290    

              310       320       330       340       350       360
pF1KB5 PEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAE
          300       310       320       330       340       350    

              370       380       390       400       410       420
pF1KB5 EGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEF
          360       370       380       390       400       410    

              430       440       450       460       470       480
pF1KB5 EREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKP
          420       430       440       450       460       470    

              490       
pF1KB5 CPVCRQPIQMIVLTYFP
       :::::::::::::::::
XP_005 CPVCRQPIQMIVLTYFP
          480       490 

>>XP_006719462 (OMIM: 164785,614401) PREDICTED: E3 ubiqu  (430 aa)
 initn: 2900 init1: 2900 opt: 2900  Z-score: 2466.3  bits: 465.6 E(85289): 1.2e-130
Smith-Waterman score: 2900; 100.0% identity (100.0% similar) in 430 aa overlap (68-497:1-430)

        40        50        60        70        80        90       
pF1KB5 PLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSF
                                     ::::::::::::::::::::::::::::::
XP_006                               MTKRLYDEKQQHIVYCSNDLLGDLFGVPSF
                                             10        20        30

       100       110       120       130       140       150       
pF1KB5 SVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSH
               40        50        60        70        80        90

       160       170       180       190       200       210       
pF1KB5 LVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSS
              100       110       120       130       140       150

       220       230       240       250       260       270       
pF1KB5 SSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDE
              160       170       180       190       200       210

       280       290       300       310       320       330       
pF1KB5 DDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLP
              220       230       240       250       260       270

       340       350       360       370       380       390       
pF1KB5 EDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQES
              280       290       300       310       320       330

       400       410       420       430       440       450       
pF1KB5 EDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIV
              340       350       360       370       380       390

       460       470       480       490       
pF1KB5 HGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
       ::::::::::::::::::::::::::::::::::::::::
XP_006 HGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
              400       410       420       430

>>XP_006719463 (OMIM: 164785,614401) PREDICTED: E3 ubiqu  (390 aa)
 initn: 2629 init1: 2629 opt: 2629  Z-score: 2237.6  bits: 423.2 E(85289): 6.8e-118
Smith-Waterman score: 2629; 100.0% identity (100.0% similar) in 390 aa overlap (108-497:1-390)

        80        90       100       110       120       130       
pF1KB5 QHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEG
                                     ::::::::::::::::::::::::::::::
XP_006                               MIYRNLVVVNQQESSDSGTSVSENRCHLEG
                                             10        20        30

       140       150       160       170       180       190       
pF1KB5 GSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISL
               40        50        60        70        80        90

       200       210       220       230       240       250       
pF1KB5 SFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEV
              100       110       120       130       140       150

       260       270       280       290       300       310       
pF1KB5 ESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEM
              160       170       180       190       200       210

       320       330       340       350       360       370       
pF1KB5 NPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSR
              220       230       240       250       260       270

       380       390       400       410       420       430       
pF1KB5 ESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLP
              280       290       300       310       320       330

       440       450       460       470       480       490       
pF1KB5 LNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
              340       350       360       370       380       390

>>NP_001138811 (OMIM: 164785,614401) E3 ubiquitin-protei  (442 aa)
 initn: 2212 init1: 2212 opt: 2212  Z-score: 1884.0  bits: 357.9 E(85289): 3.4e-98
Smith-Waterman score: 2858; 88.9% identity (88.9% similar) in 497 aa overlap (1-497:1-442)

               10        20        30        40        50        60
pF1KB5 MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 FYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 SSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDE
                                                              :::::
NP_001 -------------------------------------------------------ENSDE
                                                                   

              190       200       210       220       230       240
pF1KB5 LSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGD
         130       140       150       160       170       180     

              250       260       270       280       290       300
pF1KB5 WLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEED
         190       200       210       220       230       240     

              310       320       330       340       350       360
pF1KB5 PEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAE
         250       260       270       280       290       300     

              370       380       390       400       410       420
pF1KB5 EGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEF
         310       320       330       340       350       360     

              430       440       450       460       470       480
pF1KB5 EREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKP
         370       380       390       400       410       420     

              490       
pF1KB5 CPVCRQPIQMIVLTYFP
       :::::::::::::::::
NP_001 CPVCRQPIQMIVLTYFP
         430       440  

>>NP_001265391 (OMIM: 164785,614401) E3 ubiquitin-protei  (321 aa)
 initn: 1853 init1: 1853 opt: 1853  Z-score: 1582.1  bits: 301.6 E(85289): 2.2e-81
Smith-Waterman score: 1853; 100.0% identity (100.0% similar) in 269 aa overlap (229-497:53-321)

      200       210       220       230       240       250        
pF1KB5 FDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVE
                                     ::::::::::::::::::::::::::::::
NP_001 EQETLVRPKPLLLKLLKSVGAQKDTYTMKEDLDAGVSEHSGDWLDQDSVSDQFSVEFEVE
             30        40        50        60        70        80  

      260       270       280       290       300       310        
pF1KB5 SLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMN
             90       100       110       120       130       140  

      320       330       340       350       360       370        
pF1KB5 PPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRE
            150       160       170       180       190       200  

      380       390       400       410       420       430        
pF1KB5 SCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPL
            210       220       230       240       250       260  

      440       450       460       470       480       490       
pF1KB5 NAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
            270       280       290       300       310       320 

>--
 initn: 329 init1: 329 opt: 329  Z-score: 292.6  bits: 63.0 E(85289): 1.5e-09
Smith-Waterman score: 329; 100.0% identity (100.0% similar) in 52 aa overlap (7-58:1-52)

               10        20        30        40        50        60
pF1KB5 MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVL
             ::::::::::::::::::::::::::::::::::::::::::::::::::::  
NP_001       MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEDL
                     10        20        30        40        50    

               70        80        90       100       110       120
pF1KB5 FYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE
                                                                   
NP_001 DAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAG
           60        70        80        90       100       110    

>>NP_001138809 (OMIM: 164785,614401) E3 ubiquitin-protei  (444 aa)
 initn: 1511 init1: 1511 opt: 1524  Z-score: 1301.8  bits: 250.2 E(85289): 9e-66
Smith-Waterman score: 2876; 90.4% identity (90.4% similar) in 491 aa overlap (7-497:1-444)

               10        20        30        40        50        60
pF1KB5 MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVL
             ::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001       MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVL
                     10        20        30        40        50    

               70        80        90       100       110       120
pF1KB5 FYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE
           60        70        80        90       100       110    

              130       140       150       160       170       180
pF1KB5 SSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDE
          120       130       140       150       160       170    

              190       200       210       220       230       240
pF1KB5 LSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::      
NP_001 LSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGV------
          180       190       200       210       220              

              250       260       270       280       290       300
pF1KB5 WLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEED
                                                :::::::::::::::::::
NP_001 -----------------------------------------YQVTVYQAGESDTDSFEED
                                               230       240       

              310       320       330       340       350       360
pF1KB5 PEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAE
       250       260       270       280       290       300       

              370       380       390       400       410       420
pF1KB5 EGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEF
       310       320       330       340       350       360       

              430       440       450       460       470       480
pF1KB5 EREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKP
       370       380       390       400       410       420       

              490       
pF1KB5 CPVCRQPIQMIVLTYFP
       :::::::::::::::::
NP_001 CPVCRQPIQMIVLTYFP
       430       440    

>>NP_001138812 (OMIM: 164785,614401) E3 ubiquitin-protei  (295 aa)
 initn: 1663 init1: 1347 opt: 1373  Z-score: 1176.5  bits: 226.4 E(85289): 8.6e-59
Smith-Waterman score: 1627; 90.3% identity (90.3% similar) in 269 aa overlap (229-497:53-295)

      200       210       220       230       240       250        
pF1KB5 FDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVE
                                     ::::::::::::::::::::::::::::::
NP_001 EQETLVRPKPLLLKLLKSVGAQKDTYTMKEDLDAGVSEHSGDWLDQDSVSDQFSVEFEVE
             30        40        50        60        70        80  

      260       270       280       290       300       310        
pF1KB5 SLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMN
       ::::::::::::::::::::::                          ::::::::::::
NP_001 SLDSEDYSLSEEGQELSDEDDE--------------------------DYWKCTSCNEMN
             90       100                                 110      

      320       330       340       350       360       370        
pF1KB5 PPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRE
        120       130       140       150       160       170      

      380       390       400       410       420       430        
pF1KB5 SCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPL
        180       190       200       210       220       230      

      440       450       460       470       480       490       
pF1KB5 NAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
        240       250       260       270       280       290     

>--
 initn: 329 init1: 329 opt: 329  Z-score: 293.1  bits: 63.0 E(85289): 1.4e-09
Smith-Waterman score: 329; 100.0% identity (100.0% similar) in 52 aa overlap (7-58:1-52)

               10        20        30        40        50        60
pF1KB5 MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVL
             ::::::::::::::::::::::::::::::::::::::::::::::::::::  
NP_001       MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEDL
                     10        20        30        40        50    

               70        80        90       100       110       120
pF1KB5 FYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE
                                                                   
NP_001 DAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEDYWKCTSCNE
           60        70        80        90       100       110    

>>NP_002384 (OMIM: 602704) protein Mdm4 isoform 1 [Homo   (490 aa)
 initn: 512 init1: 346 opt: 886  Z-score: 761.4  bits: 150.4 E(85289): 1.1e-35
Smith-Waterman score: 886; 34.0% identity (64.3% similar) in 482 aa overlap (30-495:23-488)

               10        20        30        40        50        60
pF1KB5 MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVL
                                    : . ::::  :::.:...::: . .:.:::.
NP_002        MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVM
                      10        20        30        40        50   

               70        80        90       100       110       120
pF1KB5 FYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE
        :::::::.:.:::...::.:::..::::.:.:  :::::.   .: :. .:::..    
NP_002 HYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATA-
            60        70        80        90       100       110   

              130       140       150       160         170        
pF1KB5 SSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSR--PSTSSRRRAISETEENS
       ..:.. ...  . :     .: .: :  .: . : .. .    :.  . ..   ...:. 
NP_002 TTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDE
            120       130       140       150       160       170  

      180       190       200              210       220       230 
pF1KB5 DELSGERQRKRHKSDSISLSFDE-SLA------LCVIREICCERSSSSESTGTPSNPDLD
       : . .  : .  . :   :.:.: ..:      :  .:     ::..  ::   .: :. 
NP_002 DLIENLAQDETSRLD---LGFEEWDVAGLPWWFLGNLRSNYTPRSNG--STDLQTNQDVG
            180          190       200       210         220       

              240        250       260       270       280         
pF1KB5 -AGVSEHSGD-WLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQA
        : ::. . : :. ..:::.:..: ..::. :.:  . :::  ..::.  .: .:   . 
NP_002 TAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTE--QTSEEVGKVSDK--KVIEVGKNDD
       230       240       250       260         270         280   

     290       300         310       320       330       340       
pF1KB5 GESDTDSFEEDP--EISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEI
        : :. :. .:   :..  : :.:: :...: :   .: ::::::..:   : .:    .
NP_002 LE-DSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYS-DCSKLTHSL
            290       300       310       320       330        340 

       350       360       370          380       390       400    
pF1KB5 SEKAKLENSTQAEEGFDVPDCKKTI---VNDSRESCVEENDDKITQASQSQESEDYSQPS
       : .       . .:: :::::..::   :   ... ......:. .  .: :  : .. :
NP_002 STSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSS
             350       360       370       380       390       400 

          410       420       430       440       450       460    
pF1KB5 TSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHL
        :.  : :  :.. .. ...:.   :..:.    : ..:: .:. ::..: :.::.::::
NP_002 ESQETISSMGEQLDNLSEQRTD--TENMEDCQ--NLLKPCSLCEKRPRDGNIIHGRTGHL
             410       420         430         440       450       

          470       480       490       
pF1KB5 MACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
       ..:: ::..::: .  ::.:.. ::... ..  
NP_002 VTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
       460       470       480       490

>>XP_016856800 (OMIM: 602704) PREDICTED: protein Mdm4 is  (508 aa)
 initn: 512 init1: 346 opt: 886  Z-score: 761.2  bits: 150.4 E(85289): 1.2e-35
Smith-Waterman score: 886; 34.0% identity (64.3% similar) in 482 aa overlap (30-495:41-506)

                10        20        30        40        50         
pF1KB5  MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEV
                                     : . ::::  :::.:...::: . .:.:::
XP_016 DCSFFTTKMTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEV
               20        30        40        50        60        70

      60        70        80        90       100       110         
pF1KB5 LFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQ
       . :::::::.:.:::...::.:::..::::.:.:  :::::.   .: :. .:::..   
XP_016 MHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATA
               80        90       100       110       120       130

     120       130       140       150       160         170       
pF1KB5 ESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSR--PSTSSRRRAISETEEN
        ..:.. ...  . :     .: .: :  .: . : .. .    :.  . ..   ...:.
XP_016 -TTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSRED
               140       150       160       170       180         

       180       190       200              210       220       230
pF1KB5 SDELSGERQRKRHKSDSISLSFDE-SLA------LCVIREICCERSSSSESTGTPSNPDL
        : . .  : .  . :   :.:.: ..:      :  .:     ::..  ::   .: :.
XP_016 EDLIENLAQDETSRLD---LGFEEWDVAGLPWWFLGNLRSNYTPRSNG--STDLQTNQDV
     190       200          210       220       230         240    

               240        250       260       270       280        
pF1KB5 D-AGVSEHSGD-WLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQ
         : ::. . : :. ..:::.:..: ..::. :.:  . :::  ..::.  .: .:   .
XP_016 GTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTE--QTSEEVGKVSDK--KVIEVGKND
          250       260       270         280       290         300

      290       300         310       320       330       340      
pF1KB5 AGESDTDSFEEDP--EISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGE
         : :. :. .:   :..  : :.:: :...: :   .: ::::::..:   : .:    
XP_016 DLE-DSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYS-DCSKLTHS
               310       320       330       340       350         

        350       360       370          380       390       400   
pF1KB5 ISEKAKLENSTQAEEGFDVPDCKKTI---VNDSRESCVEENDDKITQASQSQESEDYSQP
       .: .       . .:: :::::..::   :   ... ......:. .  .: :  : .. 
XP_016 LSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHS
      360       370       380       390       400       410        

           410       420       430       440       450       460   
pF1KB5 STSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGH
       : :.  : :  :.. .. ...:.   :..:.    : ..:: .:. ::..: :.::.:::
XP_016 SESQETISSMGEQLDNLSEQRTD--TENMEDCQ--NLLKPCSLCEKRPRDGNIIHGRTGH
      420       430       440           450       460       470    

           470       480       490       
pF1KB5 LMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
       :..:: ::..::: .  ::.:.. ::... ..  
XP_016 LVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
          480       490       500        




497 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 21:52:55 2016 done: Sat Nov  5 21:52:56 2016
 Total Scan time: 10.850 Total Display time:  0.060

Function used was FASTA [36.3.4 Apr, 2011]
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