Result of FASTA (omim) for pF1KE0071
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE0071, 723 aa
  1>>>pF1KE0071 723 - 723 aa - 723 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.7872+/-0.000473; mu= 14.2617+/- 0.029
 mean_var=221.3777+/-45.351, 0's: 0 Z-trim(117.9): 656  B-trim: 617 in 1/53
 Lambda= 0.086200
 statistics sampled from 29643 (30413) to 29643 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.71), E-opt: 0.2 (0.357), width:  16
 Scan time: 10.710

The best scores are:                                      opt bits E(85289)
NP_005609 (OMIM: 606582) delta-like protein 1 prec ( 723) 5389 684.2  5e-196
XP_005266991 (OMIM: 606582) PREDICTED: delta-like  ( 524) 3710 475.2 2.9e-133
NP_061947 (OMIM: 605185,616589) delta-like protein ( 685) 2172 284.1 1.3e-75
NP_000205 (OMIM: 118450,187500,601920) protein jag (1218) 1771 234.5 1.9e-60
NP_660142 (OMIM: 602570) protein jagged-2 isoform  (1200) 1756 232.7 6.8e-60
NP_002217 (OMIM: 602570) protein jagged-2 isoform  (1238) 1706 226.5 5.1e-58
XP_016883196 (OMIM: 118450,187500,601920) PREDICTE (1059) 1439 193.2 4.6e-48
XP_011517019 (OMIM: 109730,190198,616028) PREDICTE (2314) 1001 139.2 1.8e-31
NP_060087 (OMIM: 109730,190198,616028) neurogenic  (2555) 1001 139.2 1.9e-31
NP_001186930 (OMIM: 102500,600275,610205) neurogen (1235)  950 132.4   1e-29
XP_011539822 (OMIM: 102500,600275,610205) PREDICTE (2432)  950 132.9 1.5e-29
XP_016856862 (OMIM: 102500,600275,610205) PREDICTE (2432)  950 132.9 1.5e-29
XP_005270958 (OMIM: 102500,600275,610205) PREDICTE (2432)  950 132.9 1.5e-29
XP_016856861 (OMIM: 102500,600275,610205) PREDICTE (2455)  950 132.9 1.5e-29
XP_011539821 (OMIM: 102500,600275,610205) PREDICTE (2467)  950 132.9 1.5e-29
NP_077719 (OMIM: 102500,600275,610205) neurogenic  (2471)  950 132.9 1.5e-29
NP_982353 (OMIM: 277300,602768) delta-like protein ( 587)  896 125.3   7e-28
NP_058637 (OMIM: 277300,602768) delta-like protein ( 618)  896 125.3 7.2e-28
NP_004548 (OMIM: 164951) neurogenic locus notch ho (2003)  892 125.5   2e-27
NP_620711 (OMIM: 607299) delta and Notch-like epid ( 737)  872 122.4 6.3e-27
XP_005259981 (OMIM: 125310,130720,600276,615293) P (2269)  858 121.4 4.1e-26
NP_000426 (OMIM: 125310,130720,600276,615293) neur (2321)  858 121.4 4.1e-26
NP_003827 (OMIM: 176290) protein delta homolog 1 i ( 383)  832 117.1 1.4e-25
NP_003052 (OMIM: 603742) slit homolog 1 protein pr (1534)  809 115.0 2.2e-24
NP_001304101 (OMIM: 176290) protein delta homolog  ( 310)  796 112.5 2.7e-24
NP_001136272 (OMIM: 602772,612424) protein eyes sh (3144)  804 114.9 5.2e-24
NP_001278938 (OMIM: 602772,612424) protein eyes sh (3165)  804 114.9 5.2e-24
NP_001244895 (OMIM: 172870,600105,604210,613835) p ( 870)  742 106.4 5.1e-22
XP_011507669 (OMIM: 172870,600105,604210,613835) P (1297)  742 106.6 6.5e-22
XP_011507667 (OMIM: 172870,600105,604210,613835) P (1349)  742 106.6 6.6e-22
NP_001244894 (OMIM: 172870,600105,604210,613835) p (1382)  742 106.6 6.7e-22
NP_957705 (OMIM: 172870,600105,604210,613835) prot (1406)  742 106.7 6.8e-22
XP_016856341 (OMIM: 172870,600105,604210,613835) P (1451)  742 106.7 6.9e-22
XP_011512212 (OMIM: 603746) PREDICTED: slit homolo (1159)  740 106.3 7.2e-22
XP_016864334 (OMIM: 603746) PREDICTED: slit homolo (1495)  740 106.4 8.3e-22
XP_011512211 (OMIM: 603746) PREDICTED: slit homolo (1499)  740 106.4 8.3e-22
XP_006714049 (OMIM: 603746) PREDICTED: slit homolo (1509)  740 106.5 8.4e-22
NP_001276065 (OMIM: 603746) slit homolog 2 protein (1521)  740 106.5 8.4e-22
NP_001276064 (OMIM: 603746) slit homolog 2 protein (1525)  740 106.5 8.4e-22
NP_004778 (OMIM: 603746) slit homolog 2 protein is (1529)  740 106.5 8.4e-22
XP_005248268 (OMIM: 603746) PREDICTED: slit homolo (1533)  740 106.5 8.5e-22
XP_011516858 (OMIM: 219730,609720,616220) PREDICTE (1276)  698 101.1 2.8e-20
NP_775960 (OMIM: 219730,609720,616220) protein cru (1285)  698 101.1 2.8e-20
XP_011516859 (OMIM: 219730,609720,616220) PREDICTE (1220)  688 99.9 6.5e-20
XP_011516860 (OMIM: 219730,609720,616220) PREDICTE (1220)  688 99.9 6.5e-20
NP_699197 (OMIM: 611691) sushi, von Willebrand fac (3571)  691 100.9 9.5e-20
XP_016859266 (OMIM: 616634) PREDICTED: sushi, nido (1382)  621 91.6 2.3e-17
NP_001258875 (OMIM: 603745) slit homolog 3 protein (1530)  620 91.5 2.6e-17
XP_016865268 (OMIM: 603745) PREDICTED: slit homolo (1460)  614 90.8 4.3e-17
NP_003053 (OMIM: 603745) slit homolog 3 protein is (1523)  614 90.8 4.4e-17


>>NP_005609 (OMIM: 606582) delta-like protein 1 precurso  (723 aa)
 initn: 5389 init1: 5389 opt: 5389  Z-score: 3640.4  bits: 684.2 E(85289): 5e-196
Smith-Waterman score: 5389; 100.0% identity (100.0% similar) in 723 aa overlap (1-723:1-723)

               10        20        30        40        50        60
pF1KE0 MGSRCALALAVLSALLCQVWSSGVFELKLQEFVNKKGLLGNRNCCRGGAGPPPCACRTFF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MGSRCALALAVLSALLCQVWSSGVFELKLQEFVNKKGLLGNRNCCRGGAGPPPCACRTFF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 RVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGGGADSAFSNPIRFPFGFTWPGTF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGGGADSAFSNPIRFPFGFTWPGTF
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 SLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCD
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 EHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKP
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE0 GECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKN
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE0 GATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYG
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE0 KICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKC
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE0 VDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSA
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE0 PVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQG
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE0 GPFPWVAVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETMNNLANCQREK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GPFPWVAVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETMNNLANCQREK
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE0 DISVSIIGATQIKNTNKKADFHGDHSADKNGFKARYPAVDYNLVQDLKGDDTAVRDAHSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DISVSIIGATQIKNTNKKADFHGDHSADKNGFKARYPAVDYNLVQDLKGDDTAVRDAHSK
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE0 RDTKCQPQGSSGEEKGTPTTLRGGEASERKRPDSGCSTSKDTKYQSVYVISEEKDECVIA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RDTKCQPQGSSGEEKGTPTTLRGGEASERKRPDSGCSTSKDTKYQSVYVISEEKDECVIA
              670       680       690       700       710       720

          
pF1KE0 TEV
       :::
NP_005 TEV
          

>>XP_005266991 (OMIM: 606582) PREDICTED: delta-like prot  (524 aa)
 initn: 4048 init1: 3710 opt: 3710  Z-score: 2513.4  bits: 475.2 E(85289): 2.9e-133
Smith-Waterman score: 3710; 99.6% identity (99.6% similar) in 486 aa overlap (1-486:1-486)

               10        20        30        40        50        60
pF1KE0 MGSRCALALAVLSALLCQVWSSGVFELKLQEFVNKKGLLGNRNCCRGGAGPPPCACRTFF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGSRCALALAVLSALLCQVWSSGVFELKLQEFVNKKGLLGNRNCCRGGAGPPPCACRTFF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 RVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGGGADSAFSNPIRFPFGFTWPGTF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGGGADSAFSNPIRFPFGFTWPGTF
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 SLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCD
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 EHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKP
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE0 GECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKN
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE0 GATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYG
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE0 KICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKC
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE0 VDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSA
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE0 PVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQG
       :::  :                                                      
XP_005 PVSSGEASERKRPDSGCSTSKDTKYQSVYVISEEKDECVIATEV                
              490       500       510       520                    

>>NP_061947 (OMIM: 605185,616589) delta-like protein 4 p  (685 aa)
 initn: 1696 init1: 1291 opt: 2172  Z-score: 1478.5  bits: 284.1 E(85289): 1.3e-75
Smith-Waterman score: 2496; 49.7% identity (70.5% similar) in 739 aa overlap (3-723:5-685)

                 10        20             30        40        50   
pF1KE0   MGSRCALALAVLSALLCQVWS-----SGVFELKLQEFVNKKGLLGNRNCCRGGAGPPP
           :: : . :.:  ::  .:.     ::::.:.::::.:..:.:..   :. :     
NP_061 MAAASRSASGWALL--LLVALWQQRAAGSGVFQLQLQEFINERGVLASGRPCEPG-----
               10          20        30        40        50        

            60        70        80        90          100       110
pF1KE0 CACRTFFRVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPD---GGGADSAFSNPIRF
         :::::::::::.:: :::  :::.:.. :::::..::.. :   :::      ::...
NP_061 --CRTFFRVCLKHFQAVVSP-GPCTFGTVSTPVLGTNSFAVRDDSSGGG-----RNPLQL
              60        70         80        90            100     

              120       130         140       150       160        
pF1KE0 PFGFTWPGTFSLIIEALHTDSPDDLATEN--PERLISRLATQRHLTVGEEWSQDLHSSGR
       ::.::::::::::::: :. . :::  :   :. :::..: :  :.::..:  : ..:  
NP_061 PFNFTWPGTFSLIIEAWHAPG-DDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTL
         110       120        130       140       150       160    

      170       180       190       200       210       220        
pF1KE0 TDLKYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLP
       : :.:::: .:...:::..:: .:. :.: :::..:   :.  : ::: : :: .:::: 
NP_061 TRLRYSYRVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLS
          170       180       190       200       210       220    

      230       240       250       260       270       280        
pF1KE0 GCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQD
       :: ::.:.:.::.:: :: ::::: :.::: . :: ::::. ::::.:.::::::::.::
NP_061 GCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQD
          230       240       250       260       270       280    

      290       300       310       320       330       340        
pF1KE0 LNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLEN
       :::::::.::::::::.:.:: ::::.:::::::. ::: ..::: .::.::::: : :.
NP_061 LNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQED
          290       300       310       320       330       340    

      350       360       370       380        390       400       
pF1KE0 SYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGG-YSCRCPVGYSGFNCEKKID
       .: : ::::.::  :: :...:::.:::::: : .  .:. :.:.:: ...: :::::.:
NP_061 GYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVD
          350       360       370       380       390       400    

       410       420       430       440       450       460       
pF1KE0 YCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSC
        :.:.::.::..:.. : . .:::. ::.: .:. .:.::: .:::.::::.:  : . :
NP_061 RCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMC
          410       420       430       440       450       460    

       470       480         490         500       510       520   
pF1KE0 TCPPGYTGRNCSA--PVSRCEHAPCHNGATCHE--RGHRYVCECARGYGGPNCQFLLPEL
       ::: :..:: : .   .. :  .:: : :::.       .::.:  :. :  :.: .  :
NP_061 TCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVG-L
          470       480       490       500       510       520    

           530       540       550        560       570       580  
pF1KE0 PPGPAVVDLTEKLEGQGGPFPWVAVCAGVIL-VLMLLLGCAAVVVCVRLRLQKHRPPADP
       ::.                ::::::  :: : ::..::: .::.:  .:::..   : : 
NP_061 PPS----------------FPWVAVSLGVGLAVLLVLLGMVAVAV-RQLRLRR---PDD-
                           530       540       550           560   

            590       600       610       620        630       640 
pF1KE0 CRGETETMNNLANCQREKDISVSIIGATQIKNTNKKADFHGDHSADK-NGFKARYPAVDY
         :  :.::::.. :..     ..: :.:.::::.: ... : . :: :  : .  ..::
NP_061 --GSREAMNNLSDFQKD-----NLIPAAQLKNTNQKKELEVDCGLDKSNCGKQQNHTLDY
              570            580       590       600       610     

             650        660       670       680       690       700
pF1KE0 NLVQDLKGDDTAV-RDAHSKRDTKCQPQGSSGEEKGTPTTLRGGEASERKRPDSGCSTSK
       ::.    :  :   .  :: .        : ::.  .:  :.. :  :  : .. ::  .
NP_061 NLAPGPLGRGTMPGKFPHSDK--------SLGEK--APLRLHS-EKPE-CRISAICSP-R
         620       630               640          650        660   

              710       720   
pF1KE0 DTKYQSVYVISEEKDECVIATEV
       :. :::: .::::..::::::::
NP_061 DSMYQSVCLISEERNECVIATEV
            670       680     

>>NP_000205 (OMIM: 118450,187500,601920) protein jagged-  (1218 aa)
 initn: 2203 init1: 962 opt: 1771  Z-score: 1206.3  bits: 234.5 E(85289): 1.9e-60
Smith-Waterman score: 1784; 41.3% identity (64.8% similar) in 576 aa overlap (2-531:11-576)

                        10         20        30        40        50
pF1KE0          MGSRCALALAVLSALLCQV-WSSGVFELKLQEFVNKKGLLGNRNCCRGGAG
                 :   .: ::.: ::  .:  .:: :::..  . : .: : : ::: ::: 
NP_000 MRSPRTRGRSGRPLSLLLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCC-GGAR
               10        20        30        40        50          

                     60        70        80        90       100    
pF1KE0 PP---PCA---CRTFFRVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGGGADSAF
        :    :.   : :.:.::::.::. :.   ::..::. :::.: ..:.:  . : :   
NP_000 NPGDRKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLKASRGND---
      60        70        80        90       100       110         

          110       120       130       140       150       160    
pF1KE0 SNPIRFPFGFTWPGTFSLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLH
        : : .::.:.:: ...:..::   :: .:  : .:. .: . . .  .. ...:.   .
NP_000 RNRIVLPFSFAWPRSYTLLVEAW--DSSND--TVQPDSIIEKASHSGMINPSRQWQTLKQ
        120       130         140         150       160       170  

          170       180       190       200       210       220    
pF1KE0 SSGRTDLKYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEP
       ..: . ..:. : .::..::: ::. ::::::: :::..: . :.:.:  :: :: :.. 
NP_000 NTGVAHFEYQIRVTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRA
            180       190       200       210       220       230  

          230       240       250       260       270       280    
pF1KE0 ICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLF
       ::  ::. .:: :  ::.:.:. :::: :::.:: .:::.:: :..:::: :. .::: .
NP_000 ICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQL
            240       250       260       270       280       290  

          290       300       310                                  
pF1KE0 CNQDLNYCTHHKPCKNGATCTNTGQGSYTCSC----------------------------
       :..:::::  :.:: ::.::.:::  .: :::                            
NP_000 CDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCK
            300       310       320       330       340       350  

                  320       330       340       350       360      
pF1KE0 ----------RPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELS
                  ::.:: ::  .::.:.:. :..::.: :: :...:.::: . :: :.:.
NP_000 ETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLD
            360       370       380       390       400       410  

        370       380       390       400       410       420      
pF1KE0 AMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDA
       :  :   :: :.  :..   ..: : :  :. : ::. .:. : .. :.: :.: :: ..
NP_000 ANECEAKPCVNAKSCKNLI-ASYYCDCLPGWMGQNCDININDCLGQ-CQNDASCRDLVNG
            420       430        440       450        460       470

        430       440       450       460       470       480      
pF1KE0 YLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCE
       : : :  :..: ::. ..:.:::.:: ::: :.. .: :.: :: :..:  :.  .. ::
NP_000 YRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCE
              480       490       500       510       520       530

        490       500       510       520        530       540     
pF1KE0 HAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPA-VVDLTEKLEGQGGPFPW
         ::.::: :..:.  : :.: . : : ::. :  .    :  :.:              
NP_000 PNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEG
              540       550       560       570       580       590

         550       560       570       580       590       600     
pF1KE0 VAVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETMNNLANCQREKDISVS
                                                                   
NP_000 VRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNS
              600       610       620       630       640       650

>--
 initn: 927 init1: 641 opt: 862  Z-score: 595.4  bits: 121.5 E(85289): 2e-26
Smith-Waterman score: 862; 37.2% identity (62.4% similar) in 298 aa overlap (245-531:578-872)

          220       230       240       250       260           270
pF1KE0 GWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPG---CL-HGTCQQ
                                     : :.  .    : .:: .   :  :: :..
NP_000 FCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKS
       550       560       570       580       590       600       

                  280       290       300       310       320      
pF1KE0 P----WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCE
            . :.:..:. : .:....: : . .::.::.:: . : .:: : :  :. :: ::
NP_000 QSGGKFTCDCNKGFTGTYCHENINDC-ESNPCRNGGTCID-GVNSYKCICSDGWEGAYCE
       610       620       630        640        650       660     

        330       340       350       360       370       380      
pF1KE0 LGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPD
        .:..:. .::.:::.: :: :.. : :  :. :: :.     : .. : ::: : :  :
NP_000 TNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGD
         670       680       690       700       710       720     

        390       400        410       420       430       440     
pF1KE0 GGYSCRCPVGYSGFNCE-KKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVD
       . ..: :: :. : .:.  . . :  .:: ::. ::  :... : :. :. :  : .:..
NP_000 A-FKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTN
          730       740       750       760       770       780    

         450       460       470       480       490       500     
pF1KE0 DCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVC
       ::.  :: :.::: :: : . : : ::..: .:   ...:. .::  :::: .. . : :
NP_000 DCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRC
          790       800       810       820       830       840    

         510       520         530       540       550       560   
pF1KE0 ECARGYGGPNCQFLL--PELPPGPAVVDLTEKLEGQGGPFPWVAVCAGVILVLMLLLGCA
        :  :..: .:: .   : .  : .. :                                
NP_000 VCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLL
          850       860       870       880       890       900    

>>NP_660142 (OMIM: 602570) protein jagged-2 isoform b pr  (1200 aa)
 initn: 1892 init1: 1002 opt: 1756  Z-score: 1196.3  bits: 232.7 E(85289): 6.8e-60
Smith-Waterman score: 1796; 43.9% identity (64.7% similar) in 556 aa overlap (9-542:13-560)

                   10        20         30        40        50     
pF1KE0     MGSRCALALAVLSALLCQVWSS-GVFELKLQEFVNKKGLLGNRNCCRGGAGPP---
                   : .: ::  :.    : :::.:. . : .: : .  :: : .      
NP_660 MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAG
               10        20        30        40        50        60

                60        70        80        90       100         
pF1KE0 PCA---CRTFFRVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGGGA-DSAFS---
        :.   : :. :::::.:::.:.:  ::.:: ..::::: .:: :: .:.: : : .   
NP_660 GCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARAR
               70        80        90       100       110       120

                110       120       130       140       150        
pF1KE0 -----NP--IRFPFGFTWPGTFSLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEE
            .:  . .:: :.:: .:.::.::   :.    .: : : :: :..    ..  ..
NP_660 AGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDND---TTPNEELLIERVSHAGMINPEDR
              130       140       150          160       170       

      160        170       180       190       200       210       
pF1KE0 WSQDLHSSGRT-DLKYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWK
       : ..:: ::..  :. . :  :::.::.  :. :::::.: :::.:: . :.:.:  :: 
NP_660 W-KSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWM
        180       190       200       210       220       230      

       220       230       240       250       260       270       
pF1KE0 GPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQ
       :  : : .:  ::.  :: :  ::::.:  :::::.::::. ::::.::.: .::::::.
NP_660 GKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCE
        240       250       260       270       280       290      

       280       290       300       310       320       330       
pF1KE0 EGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPC
        .::::.:..:::::  :.:: ::.:: :.   .: :.:  ::.: .:: .   :  .::
NP_660 TNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPC
        300       310       320       330       340       350      

       340       350       360       370       380       390       
pF1KE0 KNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGY
        ::::: .. ... : :: :. :  : :.   ::..::  :: : :. :: . : ::  .
NP_660 ANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDG-FECICPEQW
        360       370       380       390       400        410     

       400       410       420       430       440       450       
pF1KE0 SGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGT
        : .:.  .. : .. :..:. : :: ..: : :  ::.::::. . :.:::::: .:: 
NP_660 VGATCQLDVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGL
         420       430        440       450       460       470    

       460       470       480       490       500       510       
pF1KE0 CRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQ
       :.: .. : : :: :..:  : . :. :: .::.::: :..    : : :   .:: ::.
NP_660 CEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCS
          480       490       500       510       520       530    

       520          530       540       550       560       570    
pF1KE0 FLLPELP-PGPA--VVDLTEKLEGQGGPFPWVAVCAGVILVLMLLLGCAAVVVCVRLRLQ
         .:. : :: :  :.:   .  : : :                                
NP_660 --VPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTG
            540       550       560       570       580       590  

>--
 initn: 645 init1: 645 opt: 842  Z-score: 582.0  bits: 119.0 E(85289): 1.1e-25
Smith-Waterman score: 842; 37.4% identity (58.5% similar) in 294 aa overlap (265-549:571-851)

          240       250       260        270          280       290
pF1KE0 GFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTC-QQP---WQCNCQEGWGGLFCNQDLN
                                     :: : .::   ..: :. :. : .:.....
NP_660 PGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENID
              550       560       570       580       590       600

              300       310       320       330       340       350
pF1KE0 YCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSY
        :   .::.::.:: .    .. : :  :. :  :. . ..: :.::.. : : :: :..
NP_660 DCLG-QPCRNGGTCIDE-VDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDF
               610        620       630       640       650        

              360       370       380       390       400          
pF1KE0 SCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCE-KKIDYC
        :.:  :. :: :.   . :    : ::: : :: :  . : :: :..: .:   : . :
NP_660 YCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDT-FRCACPPGWKGSTCAVAKNSSC
      660       670       680       690        700       710       

     410       420       430       440       450       460         
pF1KE0 SSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTC
         .:: ::. ::  : .. : :. :. :: :  :..::   :: ::: : :::: : : :
NP_660 LPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCEC
       720       730       740       750       760       770       

     470       480       490       500       510       520         
pF1KE0 PPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAV
        ::..: .:   ...:. .::  :::: .. . : : :  : .:: ::           :
NP_660 APGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQ----------EV
       780       790       800       810       820                 

     530       540           550       560       570       580     
pF1KE0 VDLTEKLEGQGGPFP----WVAVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRG
       . . ..  ..: :::    ::  :                                    
NP_660 IGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCP
       830       840       850       860       870       880       

>>NP_002217 (OMIM: 602570) protein jagged-2 isoform a pr  (1238 aa)
 initn: 1524 init1: 1002 opt: 1706  Z-score: 1162.6  bits: 226.5 E(85289): 5.1e-58
Smith-Waterman score: 1746; 42.8% identity (65.1% similar) in 538 aa overlap (9-527:13-544)

                   10        20         30        40        50     
pF1KE0     MGSRCALALAVLSALLCQVWSS-GVFELKLQEFVNKKGLLGNRNCCRGGAGPP---
                   : .: ::  :.    : :::.:. . : .: : .  :: : .      
NP_002 MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAG
               10        20        30        40        50        60

                60        70        80        90       100         
pF1KE0 PCA---CRTFFRVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGGGA-DSAFS---
        :.   : :. :::::.:::.:.:  ::.:: ..::::: .:: :: .:.: : : .   
NP_002 GCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARAR
               70        80        90       100       110       120

                110       120       130       140       150        
pF1KE0 -----NP--IRFPFGFTWPGTFSLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEE
            .:  . .:: :.:: .:.::.::   :.    .: : : :: :..    ..  ..
NP_002 AGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDND---TTPNEELLIERVSHAGMINPEDR
              130       140       150          160       170       

      160        170       180       190       200       210       
pF1KE0 WSQDLHSSGRT-DLKYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWK
       : ..:: ::..  :. . :  :::.::.  :. :::::.: :::.:: . :.:.:  :: 
NP_002 W-KSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWM
        180       190       200       210       220       230      

       220       230       240       250       260       270       
pF1KE0 GPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQ
       :  : : .:  ::.  :: :  ::::.:  :::::.::::. ::::.::.: .::::::.
NP_002 GKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCE
        240       250       260       270       280       290      

       280       290       300       310       320       330       
pF1KE0 EGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPC
        .::::.:..:::::  :.:: ::.:: :.   .: :.:  ::.: .:: .   :  .::
NP_002 TNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPC
        300       310       320       330       340       350      

       340       350       360       370       380       390       
pF1KE0 KNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGY
        ::::: .. ... : :: :. :  : :.   ::..::  :: : :. :: . : ::  .
NP_002 ANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDG-FECICPEQW
        360       370       380       390       400        410     

       400       410       420       430       440       450       
pF1KE0 SGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGT
        : .:.   . : ..:: :. .: .:  .: : :  :..: .:  ::.::  . : .:::
NP_002 VGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDC-RGQCQHGGT
         420       430       440       450       460        470    

       460       470       480       490       500       510       
pF1KE0 CRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQ
       :.: :: ..:.:: :. ::.:    ..:  .:::.:. :.. .  . :.: .:..:: :.
NP_002 CKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCE
          480       490       500       510       520       530    

       520       530       540       550       560       570       
pF1KE0 FLLPELPPGPAVVDLTEKLEGQGGPFPWVAVCAGVILVLMLLLGCAAVVVCVRLRLQKHR
         .    :.:                                                  
NP_002 VDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAG
          540       550       560       570       580       590    

>--
 initn: 645 init1: 645 opt: 859  Z-score: 593.3  bits: 121.1 E(85289): 2.6e-26
Smith-Waterman score: 860; 35.7% identity (54.4% similar) in 373 aa overlap (183-549:552-889)

            160       170       180       190       200       210  
pF1KE0 LTVGEEWSQDLHSSGRTDLKYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVC
                                     :  :: . .:   :: ::  .:.   :  :
NP_002 CHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEG-DYYCACPDD-FGGKNCSVPREP-C
             530       540       550        560        570         

            220       230       240        250       260       270 
pF1KE0 NPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRV-GWQGRYCDECIRYPGCLHGTCQQP
        ::  :  :     . ::  . :    ::     : : .::    :.  ::   :.    
NP_002 -PG--GA-CR---VIDGCGSDAGP-GMPGTAASGVCGPHGR----CVSQPG---GN----
       580             590        600       610                    

             280       290       300       310       320       330 
pF1KE0 WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDE
       ..: :. :. : .:..... :   .::.::.:: .    .. : :  :. :  :. . ..
NP_002 FSCICDSGFTGTYCHENIDDCLG-QPCRNGGTCIDE-VDAFRCFCPSGWEGELCDTNPND
     620       630       640        650        660       670       

             340       350       360       370       380       390 
pF1KE0 CDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSC
       : :.::.. : : :: :.. :.:  :. :: :.   . :    : ::: : :: :  . :
NP_002 CLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDT-FRC
       680       690       700       710       720       730       

             400        410       420       430       440       450
pF1KE0 RCPVGYSGFNCE-KKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASS
        :: :..: .:   : . :  .:: ::. ::  : .. : :. :. :: :  :..::   
NP_002 ACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPL
        740       750       760       770       780       790      

              460       470       480       490       500       510
pF1KE0 PCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARG
       :: ::: : :::: : : : ::..: .:   ...:. .::  :::: .. . : : :  :
NP_002 PCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPG
        800       810       820       830       840       850      

              520       530       540           550       560      
pF1KE0 YGGPNCQFLLPELPPGPAVVDLTEKLEGQGGPFP----WVAVCAGVILVLMLLLGCAAVV
        .:: ::           :. . ..  ..: :::    ::  :                 
NP_002 RAGPRCQ----------EVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWC
        860                 870       880       890       900      

        570       580       590       600       610       620      
pF1KE0 VCVRLRLQKHRPPADPCRGETETMNNLANCQREKDISVSIIGATQIKNTNKKADFHGDHS
                                                                   
NP_002 GWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHL
        910       920       930       940       950       960      

>>XP_016883196 (OMIM: 118450,187500,601920) PREDICTED: p  (1059 aa)
 initn: 2203 init1: 962 opt: 1439  Z-score: 983.8  bits: 193.2 E(85289): 4.6e-48
Smith-Waterman score: 1452; 42.4% identity (65.1% similar) in 413 aa overlap (158-531:7-417)

       130       140       150       160       170       180       
pF1KE0 HTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCDEHYYGEG
                                     .:.   ...: . ..:. : .::..::: :
XP_016                         MINPSRQWQTLKQNTGVAHFEYQIRVTCDDYYYGFG
                                       10        20        30      

       190       200       210       220       230       240       
pF1KE0 CSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRV
       :. ::::::: :::..: . :.:.:  :: :: :.. ::  ::. .:: :  ::.:.:. 
XP_016 CNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQY
         40        50        60        70        80        90      

       250       260       270       280       290       300       
pF1KE0 GWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNT
       :::: :::.:: .:::.:: :..:::: :. .::: .:..:::::  :.:: ::.::.::
XP_016 GWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNT
        100       110       120       130       140       150      

       310                                             320         
pF1KE0 GQGSYTCSC--------------------------------------RPGYTGATCELGI
       :  .: :::                                       ::.:: ::  .:
XP_016 GPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNI
        160       170       180       190       200       210      

     330       340       350       360       370       380         
pF1KE0 DECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGY
       :.:.:. :..::.: :: :...:.::: . :: :.:.:  :   :: :.  :..   ..:
XP_016 DDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLI-ASY
        220       230       240       250       260       270      

     390       400       410       420       430       440         
pF1KE0 SCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCAS
        : :  :. : ::. .:. : .. :.: :.: :: ..: : :  :..: ::. ..:.:::
XP_016 YCDCLPGWMGQNCDININDCLGQ-CQNDASCRDLVNGYRCICPPGYAGDHCERDIDECAS
         280       290        300       310       320       330    

     450       460       470       480       490       500         
pF1KE0 SPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECAR
       .:: ::: :.. .: :.: :: :..:  :.  .. ::  ::.::: :..:.  : :.: .
XP_016 NPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPE
          340       350       360       370       380       390    

     510       520        530       540       550       560        
pF1KE0 GYGGPNCQFLLPELPPGPA-VVDLTEKLEGQGGPFPWVAVCAGVILVLMLLLGCAAVVVC
        : : ::. :  .    :  :.:                                     
XP_016 DYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKF
          400       410       420       430       440       450    

>--
 initn: 927 init1: 641 opt: 862  Z-score: 596.0  bits: 121.4 E(85289): 1.8e-26
Smith-Waterman score: 862; 37.2% identity (62.4% similar) in 298 aa overlap (245-531:419-713)

          220       230       240       250       260           270
pF1KE0 GWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPG---CL-HGTCQQ
                                     : :.  .    : .:: .   :  :: :..
XP_016 FCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKS
      390       400       410       420       430       440        

                  280       290       300       310       320      
pF1KE0 P----WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCE
            . :.:..:. : .:....: : . .::.::.:: . : .:: : :  :. :: ::
XP_016 QSGGKFTCDCNKGFTGTYCHENINDC-ESNPCRNGGTCID-GVNSYKCICSDGWEGAYCE
      450       460       470        480        490       500      

        330       340       350       360       370       380      
pF1KE0 LGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPD
        .:..:. .::.:::.: :: :.. : :  :. :: :.     : .. : ::: : :  :
XP_016 TNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGD
        510       520       530       540       550       560      

        390       400        410       420       430       440     
pF1KE0 GGYSCRCPVGYSGFNCE-KKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVD
       . ..: :: :. : .:.  . . :  .:: ::. ::  :... : :. :. :  : .:..
XP_016 A-FKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTN
         570       580       590       600       610       620     

         450       460       470       480       490       500     
pF1KE0 DCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVC
       ::.  :: :.::: :: : . : : ::..: .:   ...:. .::  :::: .. . : :
XP_016 DCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRC
         630       640       650       660       670       680     

         510       520         530       540       550       560   
pF1KE0 ECARGYGGPNCQFLL--PELPPGPAVVDLTEKLEGQGGPFPWVAVCAGVILVLMLLLGCA
        :  :..: .:: .   : .  : .. :                                
XP_016 VCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLL
         690       700       710       720       730       740     

>>XP_011517019 (OMIM: 109730,190198,616028) PREDICTED: n  (2314 aa)
 initn: 1396 init1: 540 opt: 1001  Z-score: 685.9  bits: 139.2 E(85289): 1.8e-31
Smith-Waterman score: 1065; 39.6% identity (61.4% similar) in 376 aa overlap (163-516:485-853)

            140       150       160       170       180       190  
pF1KE0 DDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCDEHYYGEGCSV--
                                     .:.. : .:. .:.  ::  . : .:..  
XP_011 GINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGACRDSLN-GYKCDCDPGWSGTNCDINN
          460       470       480       490        500       510   

               200       210          220          230         240 
pF1KE0 -FCRPRDDAFGHFTCGERGEK---VCNPGWKGPYCTEPI--CLPG-CDEQHGFC--DKPG
         :.    . :  :: .       .:  :..:: :   :  :  . : .: : :  :  :
XP_011 NECESNPCVNGG-TCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQ-GTCIDDVAG
           520        530       540       550       560        570 

              250           260        270            280       290
pF1KE0 -ECKCRVGWQGRYCD----ECIRYPGCLHG-TCQQP-----WQCNCQEGWGGLFCNQDLN
        .:.: . . :  :.     :   : : .:  :.:      ..: :  :: :  :. :.:
XP_011 YKCNCLLPYTGATCEVVLAPCAPSP-CRNGGECRQSEDYESFSCVCPTGWQGQTCEVDIN
             580       590        600       610       620       630

              300       310       320       330       340       350
pF1KE0 YCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSY
        :.  .::..::.: :: .:.: : :. ::.: .::  ::.: :.::.:::::::  :. 
XP_011 ECVL-SPCRHGASCQNT-HGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTA
               640        650       660       670       680        

              360       370       380       390       400       410
pF1KE0 SCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCS
        : : ::: : .:: .   ::. :: ::. :.:  :. :.: ::.:.::..::..   :.
XP_011 FCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDS-YTCTCPAGFSGIHCENNTPDCT
      690       700       710       720        730       740       

              420       430       440       450       460       470
pF1KE0 SSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCP
        : : ::. :::  ... : :  ::.: .:. .:..: :.:: .::::.:: ... ::::
XP_011 ESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCP
       750       760       770       780       790       800       

              480       490       500       510       520       530
pF1KE0 PGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVV
        :::: ::.  :  :. .::.::. : .   .: :::  :. :  :              
XP_011 QGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQ
       810       820       830       840       850       860       

              540       550       560       570       580       590
pF1KE0 DLTEKLEGQGGPFPWVAVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETM
                                                                   
XP_011 GVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYS
       870       880       890       900       910       920       

>--
 initn: 770 init1: 473 opt: 886  Z-score: 608.6  bits: 124.9 E(85289): 3.7e-27
Smith-Waterman score: 1018; 36.4% identity (63.0% similar) in 376 aa overlap (174-527:37-408)

           150       160       170       180       190          200
pF1KE0 ISRLATQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCDEHYYGEGCSV---FCRPRDDAFG
                                     .:   :  .. :. :.     :.   .:  
XP_011 CFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQ
         10        20        30        40        50        60      

                  210       220         230        240         250 
pF1KE0 HF-TC-GERG--EKVCNPGWKGPYCTEPI--CLPGCDEQHGFC-DKPGE--CKCRVGWQG
       .  :: . .:  . ::  :: :  :.: :  :  .   . . : :. .   :.:  :  :
XP_011 NGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTG
         70        80        90       100       110       120      

                260         270           280       290        300 
pF1KE0 RYC---DECIRYPGCLHGT-CQ-QPWQ----CNCQEGWGGLFCNQDLNYCT-HHKPCKNG
         :   : ::  : : .:. :. .: .    :.:  :. :  :.::.. :.   .::...
XP_011 LLCHLNDACISNP-CNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHA
        130        140       150       160       170       180     

             310       320       330       340       350       360 
pF1KE0 ATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGK
       . : ::  ::. :.:  ::::  ::. ..::  .::.: ..: :  . ..: : ::. : 
XP_011 GKCINT-LGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGV
         190        200       210       220       230       240    

             370       380       390       400       410       420 
pF1KE0 ICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCV
        ::...  ::..::...::: :. .  ..:.::.:..:  :.  .: :.:.::.:::::.
XP_011 HCEVNTDECASSPCLHNGRCLDKINE-FQCECPTGFTGHLCQYDVDECASTPCKNGAKCL
          250       260       270        280       290       300   

             430       440       450       460       470       480 
pF1KE0 DLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAP
       :  ..: : :  :..: ::. ..:.:  .:: . :.:.:::  :.: : :::::..: . 
XP_011 DGPNTYTCVCTEGYTGTHCEVDIDECDPDPC-HYGSCKDGVATFTCLCRPGYTGHHCETN
           310       320       330        340       350       360  

             490       500       510       520       530       540 
pF1KE0 VSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQGG
       ...:   ::..:.::..: . :.: : .:  ::::.. : .   .:              
XP_011 INECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTCLDKIDGYE
            370       380       390       400       410       420  

             550       560       570       580       590       600 
pF1KE0 PFPWVAVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETMNNLANCQREKD
                                                                   
XP_011 CACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSN
            430       440       450       460       470       480  

>--
 initn: 698 init1: 407 opt: 432  Z-score: 303.5  bits: 68.4 E(85289): 3.6e-10
Smith-Waterman score: 817; 39.0% identity (59.7% similar) in 305 aa overlap (238-525:854-1149)

       210       220       230       240       250       260       
pF1KE0 GEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHG-
                                     : :.  .:.:. : .  :   :   : :: 
XP_011 SSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPS-VSCEVAAQRQGVD-VARL--CQHGG
           830       840       850        860       870            

           270       280       290       300       310       320   
pF1KE0 TC---QQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGA
        :    .  .: :: :. : .:.. .. :.  .::.::::::.   :.:.:.:  :: :.
XP_011 LCVDAGNTHHCRCQAGYTGSYCEDLVDECSP-SPCQNGATCTDY-LGGYSCKCVAGYHGV
     880       890       900       910        920        930       

           330       340       350       360       370             
pF1KE0 TCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTC-------ADGP-C
       .:   ::::   ::.:::.: :: :.:.:.:: :  :  ::...  :       . .: :
XP_011 NCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKC
       940       950       960       970       980       990       

         380       390       400       410         420       430   
pF1KE0 FNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPC-SNGAK-CVDLGDAYLCRCQA
       ::.: : :.  ::::: :: :. :  ::  .. : :.:: . :.. ::.  . . :.:.:
XP_011 FNNGTCVDQV-GGYSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRA
      1000       1010      1020      1030      1040      1050      

           440       450       460          470       480       490
pF1KE0 GFSGRHCDDNVDDCASSPCANGGTCRDGVND---FSCTCPPGYTGRNCSAPVSRCEHAPC
       : .::.:.. .. : ..:: :::::  . :    : : :: :. : .:   .  :    :
XP_011 GHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRC
       1060      1070      1080      1090      1100      1110      

              500       510       520       530       540       550
pF1KE0 HNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQGGPFPWVAVCA
        ::.::    .  .: :   . ::.:::  :   :                         
XP_011 LNGGTCISGPRSPTCLCLGPFTGPECQF--PASSPCLGGNPCYNQGTCEPTSESPFYRCL
       1120      1130      1140        1150      1160      1170    

              560       570       580       590       600       610
pF1KE0 GVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETMNNLANCQREKDISVSIIGAT
                                                                   
XP_011 CPAKFNGLLCHILDYSFGGGAGRDIPPPLIEEACELPECQEDAGNKVCSLQCNNHACGWD
         1180      1190      1200      1210      1220      1230    

>--
 initn: 301 init1: 301 opt: 326  Z-score: 232.2  bits: 55.2 E(85289): 3.4e-06
Smith-Waterman score: 326; 46.8% identity (74.0% similar) in 77 aa overlap (414-490:409-484)

           390       400       410       420       430       440   
pF1KE0 SPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDN
                                     :..:. :.:  :.: : :. :..:  :. :
XP_011 DRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGT-CLDKIDGYECACEPGYTGSMCNIN
      380       390       400       410        420       430       

           450       460       470       480       490       500   
pF1KE0 VDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRY
       .:.::..:: :::::.::.: :.: :: ::   .: . :..:.  ::             
XP_011 IDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGACRDSLNGYK
       440       450       460       470       480       490       

           510       520       530       540       550       560   
pF1KE0 VCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQGGPFPWVAVCAGVILVLMLLLGCA
                                                                   
XP_011 CDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASN
       500       510       520       530       540       550       

>>NP_060087 (OMIM: 109730,190198,616028) neurogenic locu  (2555 aa)
 initn: 1396 init1: 540 opt: 1001  Z-score: 685.4  bits: 139.2 E(85289): 1.9e-31
Smith-Waterman score: 1065; 39.6% identity (61.4% similar) in 376 aa overlap (163-516:726-1094)

            140       150       160       170       180       190  
pF1KE0 DDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCDEHYYGEGCSV--
                                     .:.. : .:. .:.  ::  . : .:..  
NP_060 GINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGACRDSLN-GYKCDCDPGWSGTNCDINN
         700       710       720       730        740       750    

               200       210          220          230         240 
pF1KE0 -FCRPRDDAFGHFTCGERGEK---VCNPGWKGPYCTEPI--CLPG-CDEQHGFC--DKPG
         :.    . :  :: .       .:  :..:: :   :  :  . : .: : :  :  :
NP_060 NECESNPCVNGG-TCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQ-GTCIDDVAG
          760        770       780       790       800        810  

              250           260        270            280       290
pF1KE0 -ECKCRVGWQGRYCD----ECIRYPGCLHG-TCQQP-----WQCNCQEGWGGLFCNQDLN
        .:.: . . :  :.     :   : : .:  :.:      ..: :  :: :  :. :.:
NP_060 YKCNCLLPYTGATCEVVLAPCAPSP-CRNGGECRQSEDYESFSCVCPTGWQGQTCEVDIN
            820       830        840       850       860       870 

              300       310       320       330       340       350
pF1KE0 YCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSY
        :.  .::..::.: :: .:.: : :. ::.: .::  ::.: :.::.:::::::  :. 
NP_060 ECVL-SPCRHGASCQNT-HGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTA
              880        890       900       910       920         

              360       370       380       390       400       410
pF1KE0 SCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCS
        : : ::: : .:: .   ::. :: ::. :.:  :. :.: ::.:.::..::..   :.
NP_060 FCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDS-YTCTCPAGFSGIHCENNTPDCT
     930       940       950       960        970       980        

              420       430       440       450       460       470
pF1KE0 SSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCP
        : : ::. :::  ... : :  ::.: .:. .:..: :.:: .::::.:: ... ::::
NP_060 ESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCP
      990      1000      1010      1020      1030      1040        

              480       490       500       510       520       530
pF1KE0 PGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVV
        :::: ::.  :  :. .::.::. : .   .: :::  :. :  :              
NP_060 QGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQ
     1050      1060      1070      1080      1090      1100        

              540       550       560       570       580       590
pF1KE0 DLTEKLEGQGGPFPWVAVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETM
                                                                   
NP_060 GVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYS
     1110      1120      1130      1140      1150      1160        

>--
 initn: 1051 init1: 473 opt: 924  Z-score: 633.7  bits: 129.7 E(85289): 1.5e-28
Smith-Waterman score: 1018; 36.4% identity (63.0% similar) in 376 aa overlap (174-527:278-649)

           150       160       170       180       190          200
pF1KE0 ISRLATQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCDEHYYGEGCSV---FCRPRDDAFG
                                     .:   :  .. :. :.     :.   .:  
NP_060 GFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQ
       250       260       270       280       290       300       

                  210       220         230        240         250 
pF1KE0 HF-TC-GERG--EKVCNPGWKGPYCTEPI--CLPGCDEQHGFC-DKPGE--CKCRVGWQG
       .  :: . .:  . ::  :: :  :.: :  :  .   . . : :. .   :.:  :  :
NP_060 NGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTG
       310       320       330       340       350       360       

                260         270           280       290        300 
pF1KE0 RYC---DECIRYPGCLHGT-CQ-QPWQ----CNCQEGWGGLFCNQDLNYCT-HHKPCKNG
         :   : ::  : : .:. :. .: .    :.:  :. :  :.::.. :.   .::...
NP_060 LLCHLNDACISNP-CNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHA
       370       380        390       400       410       420      

             310       320       330       340       350       360 
pF1KE0 ATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGK
       . : ::  ::. :.:  ::::  ::. ..::  .::.: ..: :  . ..: : ::. : 
NP_060 GKCINT-LGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGV
        430        440       450       460       470       480     

             370       380       390       400       410       420 
pF1KE0 ICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCV
        ::...  ::..::...::: :. .  ..:.::.:..:  :.  .: :.:.::.:::::.
NP_060 HCEVNTDECASSPCLHNGRCLDKINE-FQCECPTGFTGHLCQYDVDECASTPCKNGAKCL
         490       500       510        520       530       540    

             430       440       450       460       470       480 
pF1KE0 DLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAP
       :  ..: : :  :..: ::. ..:.:  .:: . :.:.:::  :.: : :::::..: . 
NP_060 DGPNTYTCVCTEGYTGTHCEVDIDECDPDPC-HYGSCKDGVATFTCLCRPGYTGHHCETN
          550       560       570        580       590       600   

             490       500       510       520       530       540 
pF1KE0 VSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQGG
       ...:   ::..:.::..: . :.: : .:  ::::.. : .   .:              
NP_060 INECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTCLDKIDGYE
           610       620       630       640       650       660   

             550       560       570       580       590       600 
pF1KE0 PFPWVAVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETMNNLANCQREKD
                                                                   
NP_060 CACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSN
           670       680       690       700       710       720   

>--
 initn: 389 init1: 298 opt: 564  Z-score: 391.7  bits: 84.9 E(85289): 4.4e-15
Smith-Waterman score: 716; 37.1% identity (58.0% similar) in 264 aa overlap (217-463:20-277)

        190       200       210       220           230       240  
pF1KE0 GCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEP--ICLPG--CDEQHGFCDKPGE
                                     .:: :..:   :: :  :.  .:       
NP_060            MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANG----TEA
                          10        20        30        40         

            250          260              270       280       290  
pF1KE0 CKCRVGWQGRYCDE---CIRYPGCLHGTCQ-------QPWQCNCQEGWGGLFCNQDLNYC
       : :  .. :  :..   :.  :    :::.         . :.:  :..: .:   :.  
NP_060 CVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNA
          50        60        70        80        90       100     

            300       310       320       330       340       350  
pF1KE0 THHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSC
          .::.::.::       : : : ::..: .:. . : :  .:: :::.:  .: :: :
NP_060 CLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQA-DPCASNPCANGGQCLPFEASYIC
         110       120       130       140        150       160    

            360       370         380       390       400       410
pF1KE0 TCPPGFYGKICELSAMTCADGP--CFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCS
        :::.:.:  :. ..  :.. :  : .:: : .   :.: : : . ..: :::.    ::
NP_060 HCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEV-GSYRCVCRATHTGPNCERPYVPCS
          170       180       190        200       210       220   

              420        430       440       450       460         
pF1KE0 SSPCSNGAKCVDLGDA-YLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTC
        :::.::. :   ::. . : :  ::.:..:..:.::: .. : :::.: ::::      
NP_060 PSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRC
           230       240       250       260       270       280   

     470       480       490       500       510       520         
pF1KE0 PPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAV
                                                                   
NP_060 PPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAA
           290       300       310       320       330       340   

>--
 initn: 698 init1: 407 opt: 432  Z-score: 303.0  bits: 68.5 E(85289): 3.9e-10
Smith-Waterman score: 817; 39.0% identity (59.7% similar) in 305 aa overlap (238-525:1095-1390)

       210       220       230       240       250       260       
pF1KE0 GEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHG-
                                     : :.  .:.:. : .  :   :   : :: 
NP_060 SSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPS-VSCEVAAQRQGVD-VARL--CQHGG
         1070      1080      1090       1100      1110         1120

           270       280       290       300       310       320   
pF1KE0 TC---QQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGA
        :    .  .: :: :. : .:.. .. :.  .::.::::::.   :.:.:.:  :: :.
NP_060 LCVDAGNTHHCRCQAGYTGSYCEDLVDECSP-SPCQNGATCTDY-LGGYSCKCVAGYHGV
             1130      1140      1150       1160       1170        

           330       340       350       360       370             
pF1KE0 TCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTC-------ADGP-C
       .:   ::::   ::.:::.: :: :.:.:.:: :  :  ::...  :       . .: :
NP_060 NCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKC
     1180      1190      1200      1210      1220      1230        

         380       390       400       410         420       430   
pF1KE0 FNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPC-SNGAK-CVDLGDAYLCRCQA
       ::.: : :.  ::::: :: :. :  ::  .. : :.:: . :.. ::.  . . :.:.:
NP_060 FNNGTCVDQV-GGYSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRA
     1240       1250      1260      1270      1280      1290       

           440       450       460          470       480       490
pF1KE0 GFSGRHCDDNVDDCASSPCANGGTCRDGVND---FSCTCPPGYTGRNCSAPVSRCEHAPC
       : .::.:.. .. : ..:: :::::  . :    : : :: :. : .:   .  :    :
NP_060 GHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRC
      1300      1310      1320      1330      1340      1350       

              500       510       520       530       540       550
pF1KE0 HNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQGGPFPWVAVCA
        ::.::    .  .: :   . ::.:::  :   :                         
NP_060 LNGGTCISGPRSPTCLCLGPFTGPECQF--PASSPCLGGNPCYNQGTCEPTSESPFYRCL
      1360      1370      1380        1390      1400      1410     

              560       570       580       590       600       610
pF1KE0 GVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETMNNLANCQREKDISVSIIGAT
                                                                   
NP_060 CPAKFNGLLCHILDYSFGGGAGRDIPPPLIEEACELPECQEDAGNKVCSLQCNNHACGWD
        1420      1430      1440      1450      1460      1470     

>--
 initn: 301 init1: 301 opt: 326  Z-score: 231.8  bits: 55.3 E(85289): 3.6e-06
Smith-Waterman score: 326; 46.8% identity (74.0% similar) in 77 aa overlap (414-490:650-725)

           390       400       410       420       430       440   
pF1KE0 SPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDN
                                     :..:. :.:  :.: : :. :..:  :. :
NP_060 DRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGT-CLDKIDGYECACEPGYTGSMCNIN
     620       630       640       650        660       670        

           450       460       470       480       490       500   
pF1KE0 VDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRY
       .:.::..:: :::::.::.: :.: :: ::   .: . :..:.  ::             
NP_060 IDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGACRDSLNGYK
      680       690       700       710       720       730        

           510       520       530       540       550       560   
pF1KE0 VCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQGGPFPWVAVCAGVILVLMLLLGCA
                                                                   
NP_060 CDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASN
      740       750       760       770       780       790        

>>NP_001186930 (OMIM: 102500,600275,610205) neurogenic l  (1235 aa)
 initn: 1224 init1: 521 opt: 950  Z-score: 654.5  bits: 132.4 E(85289): 1e-29
Smith-Waterman score: 1021; 32.9% identity (51.3% similar) in 593 aa overlap (16-549:519-1098)

                              10        20         30        40    
pF1KE0                MGSRCALALAVLSALLCQVWSSG-VFELKLQEFVNKKGLLGNRNC
                                     ::    .: : .. ...  .   : : .  
NP_001 VHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAK--
      490       500       510       520       530       540        

           50        60        70        80        90          100 
pF1KE0 CRGGAGPPPCACRTFFRVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSL---PDGGGA-
       :    .   : : : :   : . . .     :: .:.      :.::..    :   :: 
NP_001 CIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQD---GIDSYTCICNPGYMGAI
        550       560       570       580          590       600   

                          110          120       130       140     
pF1KE0 -----DSAFSNP-------IRFPFGFT---WPGTFSLIIEALHTDSPDDLATENPE-RLI
            :  .:.:       : .  :.     ::: ..  :     . :: :. ::  . :
NP_001 CSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEI----NFDDCAS-NPCIHGI
           610       620       630       640           650         

          150             160              170         180         
pF1KE0 SRLATQRHLTV------GEEWSQDLHS-------SGRTDLK--YSYRFVCDEHYYGEGCS
          . .:.  :      :.. . :.         .: : ..   ..: .: :  .  .: 
NP_001 CMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCY
      660       670       680       690       700       710        

     190          200       210        220         230         240 
pF1KE0 V---FCRPRDDAFGHFTCGERGEK-VCNPGWKGPYCT--EPICLPGCDEQHGFCDK--PG
            :       :. : :  : : .:. :: :  :   .  :: .  .. : ::.   :
NP_001 SQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNG
      720       730       740       750       760       770        

              250           260        270          280       290  
pF1KE0 -ECKCRVGWQGRYC----DECIRYPGCLH-GTCQQP---WQCNCQEGWGGLFCNQDLNYC
        .: :. :..:  :    :::   : ::. ::: .    . :.:   . :  :.  :  :
NP_001 YRCTCKKGFKGYNCQVNIDECASNP-CLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPC
      780       790       800        810       820       830       

            300        310       320       330       340       350 
pF1KE0 THHKPCKNGATCTNTGQ-GSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYS
       . . ::.:.:.: .. .  :::: : ::. :  : . ::::  .:: : : : . ..:: 
NP_001 SPN-PCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYM
       840        850       860       870       880       890      

             360       370       380       390       400       410 
pF1KE0 CTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSS
       : ::::: :  :: .   :  .:: ::: : :. .  .:: :  :..: .:.  .. : :
NP_001 CECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNT-FSCLCLPGFTGDKCQTDMNECLS
        900       910       920       930        940       950     

             420       430       440       450       460       470 
pF1KE0 SPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPP
        ::.::. : :  ..: :.:::::.: ::..:...:. : : ::::: ::.:.::: :: 
NP_001 EPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPV
         960       970       980       990      1000      1010     

             480       490       500       510       520       530 
pF1KE0 GYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVD
       :.::  :   ...:   :: : .:: .    : : :  :: : ::: :.     .:    
NP_001 GFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNK
        1020      1030      1040      1050      1060      1070     

                540         550       560       570       580      
pF1KE0 LT---EKLEGQG-GPFPWV-AVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGE
        :   .: :.:   :  :. : :                                     
NP_001 GTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYC
        1080      1090      1100      1110      1120      1130     

>--
 initn: 847 init1: 439 opt: 882  Z-score: 608.8  bits: 124.0 E(85289): 3.6e-27
Smith-Waterman score: 889; 35.5% identity (57.4% similar) in 392 aa overlap (179-541:92-477)

      150       160       170       180           190           200
pF1KE0 TQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCDEHYYGEGC----SVFC---RP-RDDAFG
                                     :   . :: :    :  :   ::  . .  
NP_001 CQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTC
              70        80        90       100       110       120 

              210       220        230       240          250      
pF1KE0 HFTCGERGEKVCNPGWKGPYCT-EPICLPGCDEQHGFCDKPGE---CKCRVGWQGRYCD-
       :.   .  : .:. :. :  :     ::     . . :   ..   ::: .:. :. :. 
NP_001 HMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCET
             130       140       150       160       170       180 

            260         270          280       290       300       
pF1KE0 ---ECIRYPG-CLHG-TCQQ-P--WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNT
          ::   :: : :: :: . :  .::.: .:. : .:..    :.  .:: ::.:: .:
NP_001 DVNEC-DIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAP-SPCVNGGTCRQT
              190       200       210       220        230         

       310       320       330       340       350       360       
pF1KE0 GQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSA
       :. .. :.: ::. :.::: .::.:    :.::: :.:  :.:.: ::: . :..:  ..
NP_001 GDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDV
     240       250       260       270       280       290         

       370         380       390       400       410       420     
pF1KE0 MTCADGP--CFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGD
         :   :  : ::: :..  .:::.: :  :.:: .: ..:: :. . :. :. :.:   
NP_001 DECLLQPNACQNGGTCANR-NGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVA
     300       310        320       330       340       350        

         430       440        450        460        470       480  
pF1KE0 AYLCRCQAGFSGRHCDDNVDD-CASSPCANGGTC-RDGVN-DFSCTCPPGYTGRNCSAPV
       .. : :  : .:  :  ..:: : :.:: .:. :  . .: .. :::: :: : .:.  :
NP_001 SFSCMCPEGKAGLLC--HLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDV
      360       370         380       390       400       410      

               490       500       510       520       530         
pF1KE0 SRCEHA---PCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQ
       ..:  :   ::.... : .    . ::: .::.:: :.. . :    :   : :  :.  
NP_001 DECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATC-LDKI
        420       430       440       450       460       470      

     540       550       560       570       580       590         
pF1KE0 GGPFPWVAVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETMNNLANCQRE
       ::                                                          
NP_001 GGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDD
         480       490       500       510       520       530     

>--
 initn: 377 init1: 377 opt: 411  Z-score: 292.2  bits: 65.4 E(85289): 1.5e-09
Smith-Waterman score: 411; 44.4% identity (72.2% similar) in 108 aa overlap (375-482:1120-1226)

          350       360       370       380       390       400    
pF1KE0 DLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEK
                                     : ..: : .. .  : :.::.::.:  ::.
NP_001 PSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHY-CQCPLGYTGSYCEE
    1090      1100      1110      1120      1130       1140        

          410       420       430       440       450       460    
pF1KE0 KIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVND
       ..: :.:.::..:: : :.  .: :.:  :..: .:. .::.: ..:: ::::: : :: 
NP_001 QLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNH
     1150      1160      1170      1180      1190      1200        

          470       480       490       500       510       520    
pF1KE0 FSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELP
       :.:.::::  : . :  .                                          
NP_001 FKCSCPPGTRGMKSSLSIFHPGHCLKL                                 
     1210      1220      1230                                      




723 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 04:28:34 2016 done: Fri Nov  4 04:28:36 2016
 Total Scan time: 10.710 Total Display time:  0.260

Function used was FASTA [36.3.4 Apr, 2011]
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