Result of FASTA (omim) for pF1KB5605
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB5605, 575 aa
  1>>>pF1KB5605 575 - 575 aa - 575 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.9428+/-0.000344; mu= 13.0412+/- 0.021
 mean_var=181.2238+/-36.131, 0's: 0 Z-trim(121.4): 380  B-trim: 0 in 0/53
 Lambda= 0.095272
 statistics sampled from 37558 (38034) to 37558 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.767), E-opt: 0.2 (0.446), width:  16
 Scan time: 11.680

The best scores are:                                      opt bits E(85289)
NP_000352 (OMIM: 188040,612926,614486) thrombomodu ( 575) 4208 590.9 3.8e-168
XP_016868906 (OMIM: 602108) PREDICTED: matrilin-2  ( 896)  472 77.6   2e-13
NP_001304677 (OMIM: 602108) matrilin-2 isoform c p ( 915)  472 77.6   2e-13
XP_016868907 (OMIM: 602108) PREDICTED: matrilin-2  ( 799)  447 74.1   2e-12
XP_005250977 (OMIM: 602108) PREDICTED: matrilin-2  ( 818)  447 74.1   2e-12
NP_085072 (OMIM: 602108) matrilin-2 isoform b prec ( 937)  447 74.2 2.2e-12
NP_002371 (OMIM: 602108) matrilin-2 isoform a prec ( 956)  447 74.2 2.2e-12
NP_001290065 (OMIM: 614708) signal peptide, CUB an ( 992)  439 73.1 4.9e-12
NP_000129 (OMIM: 102370,129600,134797,154700,18490 (2871)  432 72.6 1.9e-11
NP_001157738 (OMIM: 601216,602090,613097) latent-t (1139)  418 70.3 3.9e-11
NP_066548 (OMIM: 601216,602090,613097) latent-tran (1256)  418 70.3 4.2e-11
XP_011543335 (OMIM: 601216,602090,613097) PREDICTE (1265)  418 70.3 4.2e-11
NP_001123616 (OMIM: 601216,602090,613097) latent-t (1303)  418 70.3 4.3e-11
XP_011543334 (OMIM: 601216,602090,613097) PREDICTE (1312)  418 70.3 4.3e-11
XP_011539190 (OMIM: 604266) PREDICTED: multiple ep (1364)  415 69.9 5.9e-11
XP_006710469 (OMIM: 604266) PREDICTED: multiple ep (1436)  415 70.0 6.1e-11
NP_001400 (OMIM: 604266) multiple epidermal growth (1541)  415 70.0 6.4e-11
XP_016856022 (OMIM: 604266) PREDICTED: multiple ep (1559)  415 70.0 6.5e-11
XP_011539188 (OMIM: 604266) PREDICTED: multiple ep (1560)  415 70.0 6.5e-11
XP_011539187 (OMIM: 604266) PREDICTED: multiple ep (1603)  415 70.0 6.6e-11
XP_011539189 (OMIM: 604266) PREDICTED: multiple ep (1395)  409 69.1 1.1e-10
XP_016864717 (OMIM: 121050,612570,616118) PREDICTE (2861)  413 70.0 1.2e-10
NP_001990 (OMIM: 121050,612570,616118) fibrillin-2 (2912)  413 70.0 1.2e-10
NP_001989 (OMIM: 135821) fibulin-2 isoform b precu (1184)  393 66.8 4.4e-10
NP_001158507 (OMIM: 135821) fibulin-2 isoform a pr (1231)  393 66.9 4.5e-10
NP_001004019 (OMIM: 135821) fibulin-2 isoform a pr (1231)  393 66.9 4.5e-10
NP_001159737 (OMIM: 150390) latent-transforming gr (1342)  388 66.2 7.7e-10
NP_000618 (OMIM: 150390) latent-transforming growt (1395)  388 66.2 7.9e-10
NP_001987 (OMIM: 135820,608180) fibulin-1 isoform  ( 683)  383 65.2 7.9e-10
NP_001159738 (OMIM: 150390) latent-transforming gr (1300)  387 66.1 8.2e-10
NP_001159736 (OMIM: 150390) latent-transforming gr (1353)  387 66.1 8.5e-10
XP_011531162 (OMIM: 150390) PREDICTED: latent-tran (1666)  388 66.3 8.8e-10
XP_005264374 (OMIM: 150390) PREDICTED: latent-tran (1668)  388 66.3 8.8e-10
XP_011531161 (OMIM: 150390) PREDICTED: latent-tran (1669)  388 66.3 8.8e-10
XP_011531160 (OMIM: 150390) PREDICTED: latent-tran (1680)  388 66.3 8.9e-10
XP_011531157 (OMIM: 150390) PREDICTED: latent-tran (1720)  388 66.3   9e-10
NP_996826 (OMIM: 150390) latent-transforming growt (1721)  388 66.3   9e-10
XP_011531155 (OMIM: 150390) PREDICTED: latent-tran (1722)  388 66.3   9e-10
XP_005264375 (OMIM: 150390) PREDICTED: latent-tran (1626)  387 66.2 9.6e-10
XP_016859598 (OMIM: 150390) PREDICTED: latent-tran (1679)  387 66.2 9.8e-10
XP_011531159 (OMIM: 150390) PREDICTED: latent-tran (1680)  387 66.2 9.8e-10
XP_011512706 (OMIM: 614708) PREDICTED: signal pept (1001)  382 65.3 1.1e-09
XP_011518550 (OMIM: 611747) PREDICTED: signal pept ( 695)  378 64.5 1.3e-09
NP_001164161 (OMIM: 611747) signal peptide, CUB an ( 807)  378 64.6 1.4e-09
XP_016873571 (OMIM: 611747) PREDICTED: signal pept ( 844)  378 64.6 1.5e-09
XP_005253094 (OMIM: 611747) PREDICTED: signal pept ( 873)  378 64.6 1.5e-09
XP_016873570 (OMIM: 611747) PREDICTED: signal pept ( 892)  378 64.6 1.5e-09
XP_005253093 (OMIM: 611747) PREDICTED: signal pept ( 919)  378 64.7 1.5e-09
XP_005253092 (OMIM: 611747) PREDICTED: signal pept ( 953)  378 64.7 1.6e-09
XP_016873569 (OMIM: 611747) PREDICTED: signal pept ( 958)  378 64.7 1.6e-09


>>NP_000352 (OMIM: 188040,612926,614486) thrombomodulin   (575 aa)
 initn: 4208 init1: 4208 opt: 4208  Z-score: 3139.7  bits: 590.9 E(85289): 3.8e-168
Smith-Waterman score: 4208; 100.0% identity (100.0% similar) in 575 aa overlap (1-575:1-575)

               10        20        30        40        50        60
pF1KB5 MLGVLVLGALALAGLGFPAPAEPQPGGSQCVEHDCFALYPGPATFLNASQICDGLRGHLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MLGVLVLGALALAGLGFPAPAEPQPGGSQCVEHDCFALYPGPATFLNASQICDGLRGHLM
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 TVRSSVAADVISLLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDNNTSYS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TVRSSVAADVISLLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDNNTSYS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 RWARLDLNGAPLCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RWARLDLNGAPLCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAV
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 EPGAAAAAVSITYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EPGAAAAAVSITYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAP
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 GAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNP
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 DQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDG
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB5 ECVEPVDPCFRANCEYQCQPLNQTSYLCVCAEGFAPIPHEPHRCQMFCNQTACPADCDPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ECVEPVDPCFRANCEYQCQPLNQTSYLCVCAEGFAPIPHEPHRCQMFCNQTACPADCDPN
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB5 TQASCECPEGYILDDGFICTDIDECENGGFCSGVCHNLPGTFECICGPDSALARHIGTDC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TQASCECPEGYILDDGFICTDIDECENGGFCSGVCHNLPGTFECICGPDSALARHIGTDC
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB5 DSGKVDGGDSGSGEPPPSPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DSGKVDGGDSGSGEPPPSPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLR
              490       500       510       520       530       540

              550       560       570     
pF1KB5 KKQGAARAKMEYKCAAPSKEVVLQHVRTERTPQRL
       :::::::::::::::::::::::::::::::::::
NP_000 KKQGAARAKMEYKCAAPSKEVVLQHVRTERTPQRL
              550       560       570     

>>XP_016868906 (OMIM: 602108) PREDICTED: matrilin-2 isof  (896 aa)
 initn: 346 init1: 209 opt: 472  Z-score: 362.2  bits: 77.6 E(85289): 2e-13
Smith-Waterman score: 530; 34.7% identity (57.7% similar) in 248 aa overlap (245-480:283-523)

          220       230       240       250       260       270    
pF1KB5 VAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQ
                                     :..:. .::. :  .::.  ::: .: :: 
XP_016 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA
            260       270       280       290       300       310  

          280        290       300       310       320       330   
pF1KB5 ADGRSCTA-SATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEP
        ::. :.: .   : :  ::: :: : :  ::: :.:. :. :  :.. :  .. : :. 
XP_016 EDGKRCVAVDYCASENHGCEHECV-NAD--GSYLCQCHEGFALNPDKKTCTRINYCALNK
            320       330          340       350       360         

           340       350        360       370         380          
pF1KB5 SPCPQRCVNTQGGFECHCYPNYDL-VDGECVEPVDPCFRAN--CEYQCQPLN-QTSYLCV
         : ..::: . .. :.:. .: :  .:.    :: : . .  ::  :  :: . :..: 
XP_016 PGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLC--LNTEDSFVCQ
     370       380       390       400       410         420       

     390       400           410        420       430        440   
pF1KB5 CAEGFAPIPHEPHRCQM--FC--NQTACPADC-DPNTQASCECPEGYIL-DDGFICTDID
       :.:::  : .. . :.   .:  .. .:  .: . . . .:.::::..: .::  :. .:
XP_016 CSEGFL-INEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLD
       430        440       450       460       470       480      

           450        460       470       480       490       500  
pF1KB5 ECENGGF-CSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPPSPTPG
        :  :   :   : .   .: : :     : :. :  :                      
XP_016 SCALGDHGCEHSCVSSEDSFVCQCFEGYIL-REDGKTCRRKDVCQAIDHGCEHICVNSDD
        490       500       510        520       530       540     

            510       520       530       540       550       560  
pF1KB5 STLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAPSKEVV
                                                                   
XP_016 SYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC
         550       560       570       580       590       600     

>>NP_001304677 (OMIM: 602108) matrilin-2 isoform c precu  (915 aa)
 initn: 346 init1: 209 opt: 472  Z-score: 362.1  bits: 77.6 E(85289): 2e-13
Smith-Waterman score: 530; 34.7% identity (57.7% similar) in 248 aa overlap (245-480:283-523)

          220       230       240       250       260       270    
pF1KB5 VAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQ
                                     :..:. .::. :  .::.  ::: .: :: 
NP_001 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA
            260       270       280       290       300       310  

          280        290       300       310       320       330   
pF1KB5 ADGRSCTA-SATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEP
        ::. :.: .   : :  ::: :: : :  ::: :.:. :. :  :.. :  .. : :. 
NP_001 EDGKRCVAVDYCASENHGCEHECV-NAD--GSYLCQCHEGFALNPDKKTCTRINYCALNK
            320       330          340       350       360         

           340       350        360       370         380          
pF1KB5 SPCPQRCVNTQGGFECHCYPNYDL-VDGECVEPVDPCFRAN--CEYQCQPLN-QTSYLCV
         : ..::: . .. :.:. .: :  .:.    :: : . .  ::  :  :: . :..: 
NP_001 PGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLC--LNTEDSFVCQ
     370       380       390       400       410         420       

     390       400           410        420       430        440   
pF1KB5 CAEGFAPIPHEPHRCQM--FC--NQTACPADC-DPNTQASCECPEGYIL-DDGFICTDID
       :.:::  : .. . :.   .:  .. .:  .: . . . .:.::::..: .::  :. .:
NP_001 CSEGFL-INEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLD
       430        440       450       460       470       480      

           450        460       470       480       490       500  
pF1KB5 ECENGGF-CSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPPSPTPG
        :  :   :   : .   .: : :     : :. :  :                      
NP_001 SCALGDHGCEHSCVSSEDSFVCQCFEGYIL-REDGKTCRRKDVCQAIDHGCEHICVNSDD
        490       500       510        520       530       540     

            510       520       530       540       550       560  
pF1KB5 STLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAPSKEVV
                                                                   
NP_001 SYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC
         550       560       570       580       590       600     

>>XP_016868907 (OMIM: 602108) PREDICTED: matrilin-2 isof  (799 aa)
 initn: 261 init1: 209 opt: 447  Z-score: 344.2  bits: 74.1 E(85289): 2e-12
Smith-Waterman score: 529; 33.3% identity (56.8% similar) in 264 aa overlap (245-491:283-535)

          220       230       240       250       260       270    
pF1KB5 VAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQ
                                     :..:. .::. :  .::.  ::: .: :: 
XP_016 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA
            260       270       280       290       300       310  

          280        290       300       310       320       330   
pF1KB5 ADGRSCTA-SATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEP
        ::. :.: .   : :  ::: :: : :  ::: :.:. :. :  :.. :  .: :    
XP_016 EDGKRCVAVDYCASENHGCEHECV-NAD--GSYLCQCHEGFALNPDKKTCTKIDYCASSN
            320       330          340       350       360         

           340       350        360       370         380       390
pF1KB5 SPCPQRCVNTQGGFECHCYPNYDLV-DGECVEPVDPCF--RANCEYQCQPLNQTSYLCVC
         : ..::::. .. :::  .. :  : .  . .. :   . .::..:  ... :: : :
XP_016 HGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEE-SYYCRC
     370       380       390       400       410       420         

              400         410         420         430        440   
pF1KB5 AEGFAPIPHEPHRCQMF--CNQT--ACPADCDPNTQAS--CECPEGYILDDGF-ICTDID
        .:..  :.  . :.    : :   .:   :  ::. :  :.: ::..... .  :. .:
XP_016 HRGYTLDPN-GKTCSRVDHCAQQDHGCEQLCL-NTEDSFVCQCSEGFLINEDLKTCSRVD
      430        440       450        460       470       480      

              450       460       470       480          490       
pF1KB5 EC---ENGGFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDG---GDSGSGEPPP
        :   ..:  :   : :.  .: : : :.. . :  :  :  .:.:.   :: :      
XP_016 YCLLSDHG--CEYSCVNMDRSFACQC-PEGHVLRSDGKTC--AKLDSCALGDHGCEHSCV
        490         500       510        520         530       540 

       500       510       520       530       540       550       
pF1KB5 SPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAP
                                                                   
XP_016 SSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAED
             550       560       570       580       590       600 

>--
 initn: 243 init1: 151 opt: 281  Z-score: 220.9  bits: 51.3 E(85289): 1.5e-05
Smith-Waterman score: 281; 36.8% identity (59.6% similar) in 114 aa overlap (252-362:536-646)

             230       240       250       260       270       280 
pF1KB5 LMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCT
                                     :::.: .   .  :::  :  :. ::..: 
XP_016 FACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCR
         510       520       530       540       550       560     

              290       300       310       320       330       340
pF1KB5 -ASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRC
         .. :. .  :::.:: . :   ::.: :  :.::: : .::.  : :      : . :
XP_016 RKDVCQAIDHGCEHICVNSDD---SYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHIC
         570       580          590       600       610       620  

              350        360        370       380       390        
pF1KB5 VNTQGGFECHCYPNYDLV-DGE-CVEPVDPCFRANCEYQCQPLNQTSYLCVCAEGFAPIP
       ::. ... :.:  .. :. ::. :                                    
XP_016 VNNGNSYICKCSEGFVLAEDGRRCKSITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDF
            630       640       650       660       670       680  

>>XP_005250977 (OMIM: 602108) PREDICTED: matrilin-2 isof  (818 aa)
 initn: 261 init1: 209 opt: 447  Z-score: 344.1  bits: 74.1 E(85289): 2e-12
Smith-Waterman score: 529; 33.3% identity (56.8% similar) in 264 aa overlap (245-491:283-535)

          220       230       240       250       260       270    
pF1KB5 VAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQ
                                     :..:. .::. :  .::.  ::: .: :: 
XP_005 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA
            260       270       280       290       300       310  

          280        290       300       310       320       330   
pF1KB5 ADGRSCTA-SATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEP
        ::. :.: .   : :  ::: :: : :  ::: :.:. :. :  :.. :  .: :    
XP_005 EDGKRCVAVDYCASENHGCEHECV-NAD--GSYLCQCHEGFALNPDKKTCTKIDYCASSN
            320       330          340       350       360         

           340       350        360       370         380       390
pF1KB5 SPCPQRCVNTQGGFECHCYPNYDLV-DGECVEPVDPCF--RANCEYQCQPLNQTSYLCVC
         : ..::::. .. :::  .. :  : .  . .. :   . .::..:  ... :: : :
XP_005 HGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEE-SYYCRC
     370       380       390       400       410       420         

              400         410         420         430        440   
pF1KB5 AEGFAPIPHEPHRCQMF--CNQT--ACPADCDPNTQAS--CECPEGYILDDGF-ICTDID
        .:..  :.  . :.    : :   .:   :  ::. :  :.: ::..... .  :. .:
XP_005 HRGYTLDPN-GKTCSRVDHCAQQDHGCEQLCL-NTEDSFVCQCSEGFLINEDLKTCSRVD
      430        440       450        460       470       480      

              450       460       470       480          490       
pF1KB5 EC---ENGGFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDG---GDSGSGEPPP
        :   ..:  :   : :.  .: : : :.. . :  :  :  .:.:.   :: :      
XP_005 YCLLSDHG--CEYSCVNMDRSFACQC-PEGHVLRSDGKTC--AKLDSCALGDHGCEHSCV
        490         500       510        520         530       540 

       500       510       520       530       540       550       
pF1KB5 SPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAP
                                                                   
XP_005 SSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAED
             550       560       570       580       590       600 

>--
 initn: 243 init1: 151 opt: 281  Z-score: 220.8  bits: 51.3 E(85289): 1.5e-05
Smith-Waterman score: 281; 36.8% identity (59.6% similar) in 114 aa overlap (252-362:536-646)

             230       240       250       260       270       280 
pF1KB5 LMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCT
                                     :::.: .   .  :::  :  :. ::..: 
XP_005 FACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCR
         510       520       530       540       550       560     

              290       300       310       320       330       340
pF1KB5 -ASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRC
         .. :. .  :::.:: . :   ::.: :  :.::: : .::.  : :      : . :
XP_005 RKDVCQAIDHGCEHICVNSDD---SYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHIC
         570       580          590       600       610       620  

              350        360        370       380       390        
pF1KB5 VNTQGGFECHCYPNYDLV-DGE-CVEPVDPCFRANCEYQCQPLNQTSYLCVCAEGFAPIP
       ::. ... :.:  .. :. ::. :                                    
XP_005 VNNGNSYICKCSEGFVLAEDGRRCKSITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDF
            630       640       650       660       670       680  

>>NP_085072 (OMIM: 602108) matrilin-2 isoform b precurso  (937 aa)
 initn: 261 init1: 209 opt: 447  Z-score: 343.4  bits: 74.2 E(85289): 2.2e-12
Smith-Waterman score: 529; 33.3% identity (56.8% similar) in 264 aa overlap (245-491:283-535)

          220       230       240       250       260       270    
pF1KB5 VAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQ
                                     :..:. .::. :  .::.  ::: .: :: 
NP_085 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA
            260       270       280       290       300       310  

          280        290       300       310       320       330   
pF1KB5 ADGRSCTA-SATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEP
        ::. :.: .   : :  ::: :: : :  ::: :.:. :. :  :.. :  .: :    
NP_085 EDGKRCVAVDYCASENHGCEHECV-NAD--GSYLCQCHEGFALNPDKKTCTKIDYCASSN
            320       330          340       350       360         

           340       350        360       370         380       390
pF1KB5 SPCPQRCVNTQGGFECHCYPNYDLV-DGECVEPVDPCF--RANCEYQCQPLNQTSYLCVC
         : ..::::. .. :::  .. :  : .  . .. :   . .::..:  ... :: : :
NP_085 HGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEE-SYYCRC
     370       380       390       400       410       420         

              400         410         420         430        440   
pF1KB5 AEGFAPIPHEPHRCQMF--CNQT--ACPADCDPNTQAS--CECPEGYILDDGF-ICTDID
        .:..  :.  . :.    : :   .:   :  ::. :  :.: ::..... .  :. .:
NP_085 HRGYTLDPN-GKTCSRVDHCAQQDHGCEQLCL-NTEDSFVCQCSEGFLINEDLKTCSRVD
      430        440       450        460       470       480      

              450       460       470       480          490       
pF1KB5 EC---ENGGFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDG---GDSGSGEPPP
        :   ..:  :   : :.  .: : : :.. . :  :  :  .:.:.   :: :      
NP_085 YCLLSDHG--CEYSCVNMDRSFACQC-PEGHVLRSDGKTC--AKLDSCALGDHGCEHSCV
        490         500       510        520         530       540 

       500       510       520       530       540       550       
pF1KB5 SPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAP
                                                                   
NP_085 SSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAED
             550       560       570       580       590       600 

>--
 initn: 272 init1: 151 opt: 295  Z-score: 230.5  bits: 53.3 E(85289): 4.3e-06
Smith-Waterman score: 295; 36.5% identity (58.7% similar) in 126 aa overlap (252-370:536-658)

             230       240       250       260       270       280 
pF1KB5 LMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCT
                                     :::.: .   .  :::  :  :. ::..: 
NP_085 FACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCR
         510       520       530       540       550       560     

              290       300       310       320       330       340
pF1KB5 -ASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRC
         .. :. .  :::.:: . :   ::.: :  :.::: : .::.  : :      : . :
NP_085 RKDVCQAIDHGCEHICVNSDD---SYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHIC
         570       580          590       600       610       620  

              350        360            370       380       390    
pF1KB5 VNTQGGFECHCYPNYDLV-DG----ECVE-PVDPCFRANCEYQCQPLNQTSYLCVCAEGF
       ::. ... :.:  .. :. ::    .:.: :.:  :                        
NP_085 VNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGII
            630       640       650       660       670       680  

          400       410       420       430       440       450    
pF1KB5 APIPHEPHRCQMFCNQTACPADCDPNTQASCECPEGYILDDGFICTDIDECENGGFCSGV
                                                                   
NP_085 DSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMF
            690       700       710       720       730       740  

>>NP_002371 (OMIM: 602108) matrilin-2 isoform a precurso  (956 aa)
 initn: 261 init1: 209 opt: 447  Z-score: 343.3  bits: 74.2 E(85289): 2.2e-12
Smith-Waterman score: 529; 33.3% identity (56.8% similar) in 264 aa overlap (245-491:283-535)

          220       230       240       250       260       270    
pF1KB5 VAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQ
                                     :..:. .::. :  .::.  ::: .: :: 
NP_002 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA
            260       270       280       290       300       310  

          280        290       300       310       320       330   
pF1KB5 ADGRSCTA-SATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEP
        ::. :.: .   : :  ::: :: : :  ::: :.:. :. :  :.. :  .: :    
NP_002 EDGKRCVAVDYCASENHGCEHECV-NAD--GSYLCQCHEGFALNPDKKTCTKIDYCASSN
            320       330          340       350       360         

           340       350        360       370         380       390
pF1KB5 SPCPQRCVNTQGGFECHCYPNYDLV-DGECVEPVDPCF--RANCEYQCQPLNQTSYLCVC
         : ..::::. .. :::  .. :  : .  . .. :   . .::..:  ... :: : :
NP_002 HGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEE-SYYCRC
     370       380       390       400       410       420         

              400         410         420         430        440   
pF1KB5 AEGFAPIPHEPHRCQMF--CNQT--ACPADCDPNTQAS--CECPEGYILDDGF-ICTDID
        .:..  :.  . :.    : :   .:   :  ::. :  :.: ::..... .  :. .:
NP_002 HRGYTLDPN-GKTCSRVDHCAQQDHGCEQLCL-NTEDSFVCQCSEGFLINEDLKTCSRVD
      430        440       450        460       470       480      

              450       460       470       480          490       
pF1KB5 EC---ENGGFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDG---GDSGSGEPPP
        :   ..:  :   : :.  .: : : :.. . :  :  :  .:.:.   :: :      
NP_002 YCLLSDHG--CEYSCVNMDRSFACQC-PEGHVLRSDGKTC--AKLDSCALGDHGCEHSCV
        490         500       510        520         530       540 

       500       510       520       530       540       550       
pF1KB5 SPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAP
                                                                   
NP_002 SSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAED
             550       560       570       580       590       600 

>--
 initn: 272 init1: 151 opt: 295  Z-score: 230.4  bits: 53.3 E(85289): 4.3e-06
Smith-Waterman score: 295; 36.5% identity (58.7% similar) in 126 aa overlap (252-370:536-658)

             230       240       250       260       270       280 
pF1KB5 LMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCT
                                     :::.: .   .  :::  :  :. ::..: 
NP_002 FACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCR
         510       520       530       540       550       560     

              290       300       310       320       330       340
pF1KB5 -ASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRC
         .. :. .  :::.:: . :   ::.: :  :.::: : .::.  : :      : . :
NP_002 RKDVCQAIDHGCEHICVNSDD---SYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHIC
         570       580          590       600       610       620  

              350        360            370       380       390    
pF1KB5 VNTQGGFECHCYPNYDLV-DG----ECVE-PVDPCFRANCEYQCQPLNQTSYLCVCAEGF
       ::. ... :.:  .. :. ::    .:.: :.:  :                        
NP_002 VNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGII
            630       640       650       660       670       680  

          400       410       420       430       440       450    
pF1KB5 APIPHEPHRCQMFCNQTACPADCDPNTQASCECPEGYILDDGFICTDIDECENGGFCSGV
                                                                   
NP_002 DSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMF
            690       700       710       720       730       740  

>>NP_001290065 (OMIM: 614708) signal peptide, CUB and EG  (992 aa)
 initn: 421 init1: 216 opt: 439  Z-score: 337.1  bits: 73.1 E(85289): 4.9e-12
Smith-Waterman score: 475; 33.6% identity (55.0% similar) in 238 aa overlap (244-466:73-302)

           220       230       240        250       260       270  
pF1KB5 AVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVE-NGGCEHACNAIPGAPRCQCPAGAA
                                     .:  : :.:: : :  :::  :: :  :  
NP_001 DAICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFH
             50        60        70        80        90       100  

            280        290       300       310       320           
pF1KB5 LQADGRSCT-ASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRC---EDVDD
       :  ::..:  ..     :  :.. ::   .. ::: : :. :. :. .:: :    .  .
NP_001 LAHDGHNCLDVDECAEGNGGCQQSCV---NMMGSYECHCREGFFLSDNQHTCIQRPEGMN
            110       120          130       140       150         

      330       340        350       360         370         380   
pF1KB5 CILEPSPCPQRCVNT-QGGFECHCYPNYDLVDGE--CVEPVDPCFRAN--CEYQCQPLNQ
       :. .   : . : .: .::. :.: :...:. ..  :      :  .:  :.. :.  .:
NP_001 CMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT---CNYGNGGCQHTCDDTEQ
     160       170       180       190          200       210      

           390       400         410        420       430          
pF1KB5 TSYLCVCAEGFAPIPHEPHRCQMFC--NQTACPADC-DPNTQASCECPEGYILD-DGFIC
           : :   :. .  . . :   :  :. .: . : :  : . : :: :..:. :   :
NP_001 GPR-CGCHIKFV-LHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTC
         220        230       240       250       260       270    

     440        450       460       470       480       490        
pF1KB5 TDIDECE-NGGFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPPS
        :::::. :.: :. .:.:  :.::: :                                
NP_001 KDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICVNT
          280       290       300       310       320       330    

>>NP_000129 (OMIM: 102370,129600,134797,154700,184900,60  (2871 aa)
 initn: 784 init1: 198 opt: 432  Z-score: 326.4  bits: 72.6 E(85289): 1.9e-11
Smith-Waterman score: 438; 28.9% identity (53.3% similar) in 304 aa overlap (244-520:2405-2693)

           220       230       240       250        260       270  
pF1KB5 AVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHA-CNAIPGAPRCQCPAGAA
                                     .:.: .  :... :    :. .: : .: .
NP_000 CEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYT
         2380      2390      2400      2410      2420      2430    

            280       290          300       310       320         
pF1KB5 LQADGRSCTASATQSCNDL---CEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDC
        .  : ::.    . ::.    :. .:    .  :::.: :  :: :  : . :.:.:.:
NP_000 PDITGTSCV--DLNECNQAPKPCNFIC---KNTEGSYQCSCPKGYILQEDGRSCKDLDEC
         2440        2450         2460      2470      2480         

     330       340       350            360        370       380   
pF1KB5 ILEPSPCPQRCVNTQGGFECHCYPNY-----DLVDG-ECVEPVDPCFRANCEYQCQPLNQ
         .   :   :::: ::: :.: :..     . .:. ::.  .. :   . .  ::  . 
NP_000 ATKQHNCQFLCVNTIGGFTCKCPPGFTQHHTSCIDNNECTSDINLC---GSKGICQN-TP
    2490      2500      2510      2520      2530         2540      

           390       400         410        420        430         
pF1KB5 TSYLCVCAEGFAPIPHEPHRCQMF--CNQTA-CPADCDPNTQA-SCECPEGYILDDGFI-
        :. : : .::. . .    :.    :. .  :   :.    .  : ::.::.    .  
NP_000 GSFTCECQRGFS-LDQTGSSCEDVDECEGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQ
        2550       2560      2570      2580      2590      2600    

      440       450        460       470       480       490       
pF1KB5 CTDIDECENGGFCSGV-CHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPP
       :.: .:: .. .:.:. :::  :...:.: : .   ....  :.    : .. ::.. : 
NP_000 CVDENECLSAHICGGASCHNTLGSYKCMC-PAGFQYEQFSGGCQ----DINECGSAQAPC
         2610      2620      2630       2640          2650         

           500            510         520       530       540      
pF1KB5 S----PTPGSTLT--PPA---VGLVH--SGLLIGISIASLCLVVALLALLCHLRKKQGAA
       :     : :. :   ::.   .:  :  ::. .:                          
NP_000 SYGCSNTEGGYLCGCPPGYFRIGQGHCVSGMGMGRGNPEPPVSGEMDDNSLSPEACYECK
    2660      2670      2680      2690      2700      2710         

        550       560       570                                    
pF1KB5 RAKMEYKCAAPSKEVVLQHVRTERTPQRL                               
                                                                   
NP_000 INGYPKRGRKRRSTNETDASNIEDQSETEANVSLASWDVEKTAIFAFNISHVSNKVRILE
    2720      2730      2740      2750      2760      2770         

>--
 initn: 400 init1: 171 opt: 377  Z-score: 285.6  bits: 65.1 E(85289): 3.6e-09
Smith-Waterman score: 500; 36.4% identity (56.9% similar) in 239 aa overlap (244-466:1200-1431)

           220       230       240       250       260       270   
pF1KB5 AVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAAL
                                     .::. :::::  :.   :. .:.:  : ::
NP_000 RCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFAL
    1170      1180      1190      1200      1210      1220         

           280       290          300       310       320       330
pF1KB5 QADGRSCTASATQSCND---LCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCI
       . : ::::    . :.:   .:.     :   :: : :.:  :.  . :.. : ::..: 
NP_000 MPDQRSCTD--IDECEDNPNICDGGQCTN--IPGEYRCLCYDGFMASEDMKTCVDVNECD
    1230        1240      1250        1260      1270      1280     

               340       350       360         370         380     
pF1KB5 LEPSPC-PQRCVNTQGGFECHCYPNYDLVDGE--CVEPVDPCFRA--NCEYQCQPLNQT-
       :.:. :    : ::.:.: :::  .:.   :.  :.. .. :  .  ::  .    : . 
NP_000 LNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTD-INECEIGAHNCGKHAVCTNTAG
        1290      1300      1310      1320       1330      1340    

          390          400       410       420         430         
pF1KB5 SYLCVCAEGFAPIP---HEPHRCQMFCNQTACPADCDPNTQAS--CECPEGYILDDGFIC
       :. : :. :.        .  .:.   .. .  :::  ::..:  : : :::   ::: :
NP_000 SFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCK-NTMGSYRCLCKEGYT-GDGFTC
         1350      1360      1370      1380       1390       1400  

     440        450        460       470       480       490       
pF1KB5 TDIDEC-ENGGFC-SGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPP
       ::.::: :: ..: .: : : :: ..: :                               
NP_000 TDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCH
           1410      1420      1430      1440      1450      1460  

>--
 initn: 266 init1: 136 opt: 349  Z-score: 264.8  bits: 61.2 E(85289): 5.2e-08
Smith-Waterman score: 426; 30.8% identity (50.0% similar) in 302 aa overlap (224-480:1998-2289)

           200       210       220        230       240       250  
pF1KB5 GTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPG-AVQGHWAREAPGAWDCSVENGGC
                                     :  ::: ..:..  ..     .:  :   :
NP_000 GRTCVDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEKCEDID---ECVEEPEIC
      1970      1980      1990      2000      2010         2020    

             260       270       280                               
pF1KB5 E-HACNAIPGAPRCQCPAGAALQADGRSCT----------------------ASATQSC-
          .:.   :. .: :: : .:...:: :                         . : : 
NP_000 ALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECC
         2030      2040      2050      2060      2070      2080    

              290       300       310       320       330          
pF1KB5 --------NDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQ-R
               .: :: .:  .::.     :   .:  .. :.    :.:.:  ::. : . .
NP_000 CALKGEGWGDPCE-LCPTEPDEAFRQICPYGSGIIVGPDDSAV-DMDECK-EPDVCKHGQ
         2090       2100      2110      2120       2130       2140 

     340       350       360       370         380       390       
pF1KB5 CVNTQGGFECHCYPNYDLVDGECVEPVDPCFRAN-C-EYQCQPLNQTSYLCVCAEGFAPI
       :.::.:...:.:  .: :. .:::. .: :  .: : .  :. .   .. :.: ::: : 
NP_000 CINTDGSYRCECPFGYILAGNECVD-TDECSVGNPCGNGTCKNVIG-GFECTCEEGFEPG
            2150      2160       2170      2180       2190         

       400       410         420         430        440       450  
pF1KB5 PHEPHRCQMFCNQTA--CPADCDPNTQAS--CECPEGYIL-DDGFICTDIDECENGGF-C
       :    .    : :.   :   :  :: .:  :.:: ::.: .:  .: : ::::.:   :
NP_000 PMMTCEDINECAQNPLLCAFRC-VNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDC
    2200      2210      2220       2230      2240      2250        

                460       470       480       490       500        
pF1KB5 SGV---CHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPPSPTPGSTLTPP
       .     :.:: ::. :::::     :  :  :                            
NP_000 TEKQMECKNLIGTYMCICGPGYQ-RRPDGEGCVDENECQTKPGICENGRCLNTRGSYTCE
     2260      2270      2280       2290      2300      2310       

      510       520       530       540       550       560        
pF1KB5 AVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAPSKEVVLQHVRT
                                                                   
NP_000 CNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEI
      2320      2330      2340      2350      2360      2370       

>--
 initn: 320 init1: 171 opt: 314  Z-score: 238.8  bits: 56.4 E(85289): 1.5e-06
Smith-Waterman score: 394; 30.6% identity (51.2% similar) in 252 aa overlap (244-480:1449-1687)

           220       230       240       250       260       270   
pF1KB5 AVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAAL
                                     .::. :     .:. .::  ::.:  :  :
NP_000 QCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYEL
     1420      1430      1440      1450      1460      1470        

           280       290       300         310       320           
pF1KB5 QADGRSCTASATQSCNDLCEHFCVPNP--DQPGSYSCMCETGYRLAADQHRCEDV--DDC
       . .: .::   .. : :     :. .   . :::: : :   ..:   .  : :.   .:
NP_000 DRSGGNCT--DVNECLD--PTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNC
     1480        1490        1500      1510      1520      1530    

     330       340       350       360       370       380         
pF1KB5 ILEPSPCPQRCVNTQGGFECHCYPNYDLVDGECVEPVDPCFRANCEYQCQPLNQTSY--L
        :.  :   :  :  :   :    .  .  . :   .   . . ::. :  .: . :  :
NP_000 YLDIRP---RGDN--GDTACSNEIGVGVSKASCCCSLGKAWGTPCEM-CPAVNTSEYKIL
         1540           1550      1560      1570       1580        

       390            400       410       420         430          
pF1KB5 CVCAEGFAPIP-----HEPHRCQMFCNQTACPADCDPNTQAS--CECPEGYILD-DGFIC
       :  .::: : :     ..  .:: .     : .    :: .:  :.:: :: :. :  .:
NP_000 CPGGEGFRPNPITVILEDIDECQEL--PGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVC
     1590      1600      1610        1620      1630      1640      

     440       450        460       470       480       490        
pF1KB5 TDIDECENGGFCS-GVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPPS
        :..:::. :.:. :.:.:  :.. ::: ::  .  . :..:                  
NP_000 DDVNECETPGICGPGTCYNTVGNYTCICPPDY-MQVNGGNNCMDMRRSLCYRNYYADNQT
       1650      1660      1670       1680      1690      1700     

      500       510       520       530       540       550        
pF1KB5 PTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAPS
                                                                   
NP_000 CDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPV
        1710      1720      1730      1740      1750      1760     

>--
 initn: 208 init1: 142 opt: 297  Z-score: 226.2  bits: 54.1 E(85289): 7.4e-06
Smith-Waterman score: 380; 34.2% identity (59.7% similar) in 196 aa overlap (291-472:459-645)

              270       280       290        300       310         
pF1KB5 GAPRCQCPAGAALQADGRSCTASATQSCNDLCEH-FCVPNPDQPGSYSCMCETGYRLAAD
                                     ::..  :.:.:   ::: : :. :..:   
NP_000 RPPVEYLYPSREPPRVLPVNVTDYCQLVRYLCQNGRCIPTP---GSYRCECNKGFQLDL-
      430       440       450       460          470       480     

     320       330        340       350         360       370      
pF1KB5 QHRCEDVDDCILEPSPCPQ-RCVNTQGGFECHCYPNYD--LVDGECVEPVDPCFRAN--C
       . .: :::.:  : .::   .:.:.::.. :.:  .:.  :.  :: . .: :.. .  :
NP_000 RGECIDVDEC--EKNPCAGGECINNQGSYTCQCRAGYQSTLTRTEC-RDIDECLQNGRIC
          490         500       510       520        530       540 

           380       390       400          410       420          
pF1KB5 EY-QCQPLNQTSYLCVCAEGFAPIPHEPHRCQMF--CN-QTACPADCDPNTQAS--CECP
       .  .:   .  :. :::  ::  . .. . :. .  :. .. :      : ..:  : : 
NP_000 NNGRCINTDG-SFHCVCNAGFH-VTRDGKNCEDMDECSIRNMCLNGMCINEDGSFKCICK
             550        560        570       580       590         

      430        440       450        460       470       480      
pF1KB5 EGYIL-DDGFICTDIDECENGGFC-SGVCHNLPGTFECICGPDSALARHIGTDCDSGKVD
        :. : .::  : ::.:::. :.: .: : :  :...: : :  :.              
NP_000 PGFQLASDGRYCKDINECETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRS
     600       610       620       630       640       650         

        490       500       510       520       530       540      
pF1KB5 GGDSGSGEPPPSPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAA
                                                                   
NP_000 TCYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTS
     660       670       680       690       700       710         

>--
 initn: 216 init1: 124 opt: 296  Z-score: 225.4  bits: 53.9 E(85289): 8.1e-06
Smith-Waterman score: 360; 30.6% identity (52.9% similar) in 242 aa overlap (237-462:1771-1996)

        210       220       230       240       250       260      
pF1KB5 LPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQ
                                     :: ::.  :  :::    .:  . :. ::.
NP_000 TDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGV--C--ENG----VCINMVGSFRCE
             1750      1760      1770          1780          1790  

        270       280       290         300       310       320    
pF1KB5 CPAGAALQADGRSCTASATQSCNDLCEH--FCVPNPDQPGSYSCMCETGYRLAADQHRCE
       ::.:   .     :      . . .:..   :.   .  ::: : :. :::...  . :.
NP_000 CPVGFFYNDKLLVCEDIDECQNGPVCQRNAECI---NTAGSYRCDCKPGYRFTSTGQ-CN
           1800      1810      1820         1830      1840         

          330        340       350       360         370        380
pF1KB5 DVDDCILEPSPCPQ-RCVNTQGGFECHCYPNYDLVDGE--CVEPVDPCFRANC-EYQCQP
       : ..:   :. : . .:..: :.: : :. ..   : .  :.. .. : :  : .  :. 
NP_000 DRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLD-INECERDACGNGTCRN
     1850      1860      1870      1880      1890       1900       

              390       400            410       420         430   
pF1KB5 LNQTSYLCVCAEGFAPIPHEPHRCQMF--C---NQTACPADCDPNTQAS--CECPEGY-I
        .  :. : : .::  . :. . :     :   : . :      :: .:  :.: ::: .
NP_000 -TIGSFNCRCNHGFI-LSHN-NDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEV
       1910      1920        1930      1940      1950      1960    

            440         450       460       470       480       490
pF1KB5 LDDGFICTDIDEC--ENGGFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDS
         ::  :.::.::  :      :.:.:: :..                            
NP_000 APDGRTCVDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEKCEDIDECVEEPEIC
         1970      1980      1990      2000      2010      2020    

              500       510       520       530       540       550
pF1KB5 GSGEPPPSPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKM
                                                                   
NP_000 ALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECC
         2030      2040      2050      2060      2070      2080    

>>NP_001157738 (OMIM: 601216,602090,613097) latent-trans  (1139 aa)
 initn: 375 init1: 216 opt: 418  Z-score: 320.8  bits: 70.3 E(85289): 3.9e-11
Smith-Waterman score: 463; 27.9% identity (47.0% similar) in 481 aa overlap (103-507:509-961)

             80        90       100       110        120       130 
pF1KB5 LLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDN-NTSYSRWARLDLNGAP
                                     :: ::.   :: . :   .:  :: . :: 
NP_001 DYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHV-GAG
      480       490       500       510       520       530        

             140       150       160       170       180       190 
pF1KB5 LCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAVEPGAAAAAVSI
         :  :: ..  : . :       . :   .:: .: ..::.  .     ::    :   
NP_001 --GRSCVDLN--ECAKP-------HLC---GDGGFC-INFPGHYK-CNCYPGYRLKASRP
         540         550                  560        570       580 

             200       210       220       230        240       250
pF1KB5 TYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWA-REAPGAWDCSVENG
            .  .  : .. : :.     : ... .   :    ::  : :..    .:. :..
NP_001 PVCEDID-ECRDPSSCPDGKCEN-KPGSFKCIACQPGYRSQGGGACRDVN---ECA-EGS
              590       600        610       620          630      

               260       270       280       290        300        
pF1KB5 GCEHA-CNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEH-FCVPNPDQPGSYSC
        :  . :. .::. :: :  : :   :::::        .:.:.. .:    . :::..:
NP_001 PCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGIC---SNTPGSFQC
         640       650       660       670       680          690  

      310       320       330        340       350       360       
pF1KB5 MCETGYRLAADQHRCEDVDDCILEPSPC-PQRCVNTQGGFECHCYPNYDLVDGECVEPVD
       .: .::.:. :. .:::.:.: . :. :    :.::.:...: :  .. :: :.  . .:
NP_001 QCLSGYHLSRDRSHCEDIDECDF-PAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDID
            700       710        720       730       740       750 

       370           380       390                  400            
pF1KB5 PCFR--ANC--EYQCQPLNQTSYLCVCAEGFAPI-----------PHEPHRCQM------
        : .  . :  .  :. : : ::.::: :::.:            ::. ..: .      
NP_001 ECSQDPSLCLPHGACKNL-QGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTV
             760        770       780       790       800       810

                410       420                      430             
pF1KB5 FCN--------QTACPADCDPNTQASCE---------------CPEG--YILDDGFIC--
       ::.        :  :  .   .    ::               ::.:  :  :....   
NP_001 FCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYG
              820       830       840       850       860       870

         440         450        460           470              480 
pF1KB5 ----TDIDECENGG--FCS-GVCHNLPGTFECICGP----DSALARHIGTD-------CD
            :::::   :  .:. : : :    .:: :      :. : . . .:       : 
NP_001 IPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCR
              880       890       900       910       920       930

                490         500       510       520       530      
pF1KB5 SGKVD---GGDSGSGEPPP--SPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALL
       .:  .   ::   .  ::   ::.  . :.:                             
NP_001 NGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAG
              940       950       960       970       980       990

        540       550       560       570                          
pF1KB5 CHLRKKQGAARAKMEYKCAAPSKEVVLQHVRTERTPQRL                     
                                                                   
NP_001 PALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSS
             1000      1010      1020      1030      1040      1050




575 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 21:09:14 2016 done: Sat Nov  5 21:09:16 2016
 Total Scan time: 11.680 Total Display time:  0.110

Function used was FASTA [36.3.4 Apr, 2011]
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