Result of FASTA (omim) for pF1KB9970
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB9970, 703 aa
  1>>>pF1KB9970 703 - 703 aa - 703 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.2010+/-0.000501; mu= 16.4251+/- 0.031
 mean_var=182.2533+/-34.980, 0's: 0 Z-trim(114.6): 504  B-trim: 111 in 1/52
 Lambda= 0.095003
 statistics sampled from 23918 (24541) to 23918 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.633), E-opt: 0.2 (0.288), width:  16
 Scan time:  8.880

The best scores are:                                      opt bits E(85289)
NP_006477 (OMIM: 135820,608180) fibulin-1 isoform  ( 703) 5098 712.5 1.4e-204
NP_006476 (OMIM: 135820,608180) fibulin-1 isoform  ( 601) 4179 586.4 1.1e-166
NP_006478 (OMIM: 135820,608180) fibulin-1 isoform  ( 566) 4172 585.4  2e-166
NP_001987 (OMIM: 135820,608180) fibulin-1 isoform  ( 683) 4172 585.5 2.3e-166
NP_001989 (OMIM: 135821) fibulin-2 isoform b precu (1184) 1858 268.7 9.3e-71
NP_001004019 (OMIM: 135821) fibulin-2 isoform a pr (1231) 1729 251.0   2e-65
NP_001158507 (OMIM: 135821) fibulin-2 isoform a pr (1231) 1729 251.0   2e-65
XP_006713089 (OMIM: 135821) PREDICTED: fibulin-2 i (1192) 1308 193.3 4.6e-48
XP_011525684 (OMIM: 604710,613177) PREDICTED: late (1554)  749 116.9 6.2e-25
XP_016882866 (OMIM: 608529) PREDICTED: fibrillin-3 (1948)  744 116.3 1.1e-24
XP_016864717 (OMIM: 121050,612570,616118) PREDICTE (2861)  738 115.7 2.5e-24
NP_001990 (OMIM: 121050,612570,616118) fibrillin-2 (2912)  738 115.7 2.6e-24
XP_011508340 (OMIM: 603075,608548) PREDICTED: hemi (5518)  697 110.5 1.8e-22
XP_016857926 (OMIM: 603075,608548) PREDICTED: hemi (4976)  692 109.7 2.8e-22
NP_114141 (OMIM: 603075,608548) hemicentin-1 precu (5635)  692 109.8   3e-22
XP_011535067 (OMIM: 251750,600975,602091,613086,61 (1694)  682 107.7 3.8e-22
NP_000419 (OMIM: 251750,600975,602091,613086,61481 (1821)  682 107.8   4e-22
XP_011539189 (OMIM: 604266) PREDICTED: multiple ep (1395)  678 107.1   5e-22
XP_016882843 (OMIM: 604710,613177) PREDICTED: late (1438)  670 106.0 1.1e-21
XP_011525682 (OMIM: 604710,613177) PREDICTED: late (1593)  670 106.0 1.1e-21
XP_011525689 (OMIM: 604710,613177) PREDICTED: late (1421)  658 104.3 3.4e-21
XP_011525688 (OMIM: 604710,613177) PREDICTED: late (1436)  658 104.3 3.4e-21
XP_011525687 (OMIM: 604710,613177) PREDICTED: late (1478)  658 104.3 3.4e-21
XP_011525686 (OMIM: 604710,613177) PREDICTED: late (1480)  658 104.3 3.4e-21
XP_011525685 (OMIM: 604710,613177) PREDICTED: late (1522)  658 104.4 3.5e-21
XP_016882842 (OMIM: 604710,613177) PREDICTED: late (1549)  658 104.4 3.5e-21
NP_001036010 (OMIM: 604710,613177) latent-transfor (1557)  658 104.4 3.5e-21
NP_003564 (OMIM: 604710,613177) latent-transformin (1587)  658 104.4 3.6e-21
XP_016882841 (OMIM: 604710,613177) PREDICTED: late (1591)  658 104.4 3.6e-21
XP_011525683 (OMIM: 604710,613177) PREDICTED: late (1593)  658 104.4 3.6e-21
XP_011525681 (OMIM: 604710,613177) PREDICTED: late (1595)  658 104.4 3.6e-21
XP_011525680 (OMIM: 604710,613177) PREDICTED: late (1611)  658 104.4 3.6e-21
NP_001036009 (OMIM: 604710,613177) latent-transfor (1624)  658 104.4 3.6e-21
XP_011525679 (OMIM: 604710,613177) PREDICTED: late (1635)  658 104.4 3.6e-21
XP_011525678 (OMIM: 604710,613177) PREDICTED: late (1662)  658 104.4 3.7e-21
XP_016868907 (OMIM: 602108) PREDICTED: matrilin-2  ( 799)  637 101.1 1.8e-20
XP_005250977 (OMIM: 602108) PREDICTED: matrilin-2  ( 818)  637 101.1 1.8e-20
NP_085072 (OMIM: 602108) matrilin-2 isoform b prec ( 937)  637 101.2 1.9e-20
NP_002371 (OMIM: 602108) matrilin-2 isoform a prec ( 956)  637 101.2   2e-20
XP_016882867 (OMIM: 608529) PREDICTED: fibrillin-3 (1595)  636 101.4 2.9e-20
XP_016868906 (OMIM: 602108) PREDICTED: matrilin-2  ( 896)  623 99.3 7.1e-20
NP_001304677 (OMIM: 602108) matrilin-2 isoform c p ( 915)  623 99.3 7.2e-20
XP_016859599 (OMIM: 150390) PREDICTED: latent-tran (1639)  621 99.3 1.2e-19
XP_011539190 (OMIM: 604266) PREDICTED: multiple ep (1364)  566 91.7   2e-17
NP_001400 (OMIM: 604266) multiple epidermal growth (1541)  566 91.8 2.2e-17
XP_016856022 (OMIM: 604266) PREDICTED: multiple ep (1559)  566 91.8 2.2e-17
XP_011539188 (OMIM: 604266) PREDICTED: multiple ep (1560)  566 91.8 2.2e-17
XP_011539187 (OMIM: 604266) PREDICTED: multiple ep (1603)  566 91.8 2.3e-17
XP_011531164 (OMIM: 150390) PREDICTED: latent-tran (1248)  557 90.4 4.6e-17
NP_001159738 (OMIM: 150390) latent-transforming gr (1300)  557 90.4 4.7e-17


>>NP_006477 (OMIM: 135820,608180) fibulin-1 isoform D pr  (703 aa)
 initn: 5098 init1: 5098 opt: 5098  Z-score: 3793.7  bits: 712.5 E(85289): 1.4e-204
Smith-Waterman score: 5098; 100.0% identity (100.0% similar) in 703 aa overlap (1-703:1-703)

               10        20        30        40        50        60
pF1KB9 MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB9 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB9 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB9 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB9 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB9 TCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTV
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB9 ISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVV
              610       620       630       640       650       660

              670       680       690       700   
pF1KB9 RQVRPIVGPFHAVLKLEMNYVVGGVVSHRNVVNVHIFVSEYWF
       :::::::::::::::::::::::::::::::::::::::::::
NP_006 RQVRPIVGPFHAVLKLEMNYVVGGVVSHRNVVNVHIFVSEYWF
              670       680       690       700   

>>NP_006476 (OMIM: 135820,608180) fibulin-1 isoform B pr  (601 aa)
 initn: 4541 init1: 4179 opt: 4179  Z-score: 3113.7  bits: 586.4 E(85289): 1.1e-166
Smith-Waterman score: 4179; 99.3% identity (99.8% similar) in 571 aa overlap (1-571:1-571)

               10        20        30        40        50        60
pF1KB9 MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB9 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB9 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB9 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB9 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB9 TCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTV
       :::::::::::::::::::::::::: ...:                             
NP_006 TCFNIQGGFRCLAFECPENYRRSAATQKSKKGRQNTPAGSSKEDCRVLPWKQGLEDTHLD
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB9 ISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVV
                                                                   
NP_006 A                                                           
                                                                   

>>NP_006478 (OMIM: 135820,608180) fibulin-1 isoform A pr  (566 aa)
 initn: 4172 init1: 4172 opt: 4172  Z-score: 3108.8  bits: 585.4 E(85289): 2e-166
Smith-Waterman score: 4172; 100.0% identity (100.0% similar) in 566 aa overlap (1-566:1-566)

               10        20        30        40        50        60
pF1KB9 MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB9 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB9 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB9 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB9 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB9 TCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTV
       ::::::::::::::::::::::::::                                  
NP_006 TCFNIQGGFRCLAFECPENYRRSAAT                                  
              550       560                                        

>>NP_001987 (OMIM: 135820,608180) fibulin-1 isoform C pr  (683 aa)
 initn: 4172 init1: 4172 opt: 4172  Z-score: 3107.9  bits: 585.5 E(85289): 2.3e-166
Smith-Waterman score: 4230; 85.7% identity (90.3% similar) in 700 aa overlap (1-699:1-680)

               10        20        30        40        50        60
pF1KB9 MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB9 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB9 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB9 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB9 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
              490       500       510       520       530       540

              550       560       570        580       590         
pF1KB9 TCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIK-SCRPNDVTCVFDPVHTISHT
       ::::::::::::::::::::::::::         :: .  :. :   :   :.. :.. 
NP_001 TCFNIQGGFRCLAFECPENYRRSAAT---------RCERLPCHENR-ECSKLPLR-ITYY
              550       560                570        580          

     600       610       620       630       640       650         
pF1KB9 VISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGV
        .:.::  ..  :  ..:   . :   .   .. . :: :: .  :    : ..  . ::
NP_001 HLSFPT--NIQAPA-VVF--RMGPSSAVPGDSMQLAITGGNEEGFFTT--RKVSPHS-GV
     590         600          610       620       630          640 

     660       670       680       690       700   
pF1KB9 VRQVRPIVGPFHAVLKLEMNYVVGGVVSHRNVVNVHIFVSEYWF
       :  ..:.  :   .: ..:.    :.::   :... ::::    
NP_001 VALTKPVPEPRDLLLTVKMDLSRHGTVSSF-VAKLFIFVSAEL 
             650       660       670        680    

>>NP_001989 (OMIM: 135821) fibulin-2 isoform b precursor  (1184 aa)
 initn: 2130 init1: 1039 opt: 1858  Z-score: 1391.3  bits: 268.7 E(85289): 9.3e-71
Smith-Waterman score: 1996; 41.4% identity (61.4% similar) in 736 aa overlap (61-701:472-1182)

               40        50        60        70        80        90
pF1KB9 VLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELHCATGISLANEQDR
                                     :: .:..:: : :.:  : .:.  :.: . 
NP_001 IETCCAAGQQWAIDNDECLEIPESGTEDNVCRTAQRHCCVSYLQEKSCMAGVLGAKEGET
             450       460       470       480       490       500 

              100       110       120       130       140          
pF1KB9 CATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACC------
       :..   :: :   .. :.:: :: ::  ..:.::::: .  .:: :..:. .::      
NP_001 CGAE--DNDSCGISLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEGEEPL
               510       520       530       540       550         

                           150                                     
pF1KB9 -----------------VKSQETG--------------------DLD-------------
                        :.  : .                    : :             
NP_001 IVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDECLLLPGELCQHL
     560       570       580       590       600       610         

                        160             170                        
pF1KB9 ----VGG----------LQETDKIIEVE------EEQEDPYLN-----------------
           ::.          ::.  .  . :      :  ..: :.                 
NP_001 CINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLPQ
     620       630       640       650       660       670         

        180       190       200       210       220       230      
pF1KB9 -DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT
        . :. .::::: :  .:  ..:::: :: ...:::::::.:::.:  :.:  :: :.::
NP_001 PNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNT
     680       690       700       710       720       730         

        240       250       260       270       280       290      
pF1KB9 VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS
       .:::.: .  .:  :: : .:. :.:.:::  : :.: : :.:::: ::: :. . .: .
NP_001 LGSFHCYKALTCEPGYAL-KDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMD
     740       750        760       770       780       790        

        300       310       320       330       340       350      
pF1KB9 GFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVD
       ::.::  :::.::::: :.: ::  : .:::: ::::::.:   :.:::: ...::.:::
NP_001 GFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVD
      800       810       820       830       840       850        

        360       370       380       390       400       410      
pF1KB9 VDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCE
       :.::   .. ::.:. : : :::.::.::.:.  :...: :.:::::   ::::: : ::
NP_001 VNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCE
      860       870       880       890       900       910        

        420       430       440       450       460       470      
pF1KB9 NTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDG
       :::::: :::. :: :..::. :::.::: .. :::::::.:::::::::.::::.. ::
NP_001 NTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLAE-DG
      920       930       940       950       960       970        

        480       490       500       510       520       530      
pF1KB9 VTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNC
        :: ::::::   .: .:..::.:.:::.::.:: .:: .. :::.:.:.:::. : :::
NP_001 HTCTDIDECA-QGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNC
       980        990      1000      1010      1020      1030      

        540       550       560       570       580       590      
pF1KB9 SINETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTI
       :  ::: ::::.:::: :::: ::      .:  ::   .: ..   . . :  .:.. :
NP_001 SEAETCHNIQGSFRCLRFECPPNY------VQVSKT---KCERTTCHDFLECQNSPAR-I
       1040      1050      1060               1070      1080       

        600       610       620       630        640       650     
pF1KB9 SHTVISLPTFREFTRPEEIIFLRAITPPHPASQANII-FDITEGNLRDSFDIIKRYMDGM
       .:  ... :   .  : .:. .     : ::  .. : ..: .:: .  :    : ....
NP_001 THYQLNFQT--GLLVPAHIFRI----GPAPAFTGDTIALNIIKGNEEGYFG--TRRLNAY
       1090        1100          1110      1120      1130          

         660       670       680       690       700   
pF1KB9 TVGVVRQVRPIVGPFHAVLKLEMNYVVGGVVSHRNVVNVHIFVSEYWF
       : :::   : .. :   .: .::.    : :.   ....::: . .  
NP_001 T-GVVYLQRAVLEPRDFALDVEMKLWRQGSVT-TFLAKMHIFFTTFAL
      1140      1150      1160       1170      1180    

>>NP_001004019 (OMIM: 135821) fibulin-2 isoform a precur  (1231 aa)
 initn: 2090 init1: 1039 opt: 1729  Z-score: 1295.6  bits: 251.0 E(85289): 2e-65
Smith-Waterman score: 1826; 39.5% identity (59.3% similar) in 740 aa overlap (36-701:521-1229)

          10        20        30        40        50         60    
pF1KB9 PSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDC-SLPYATESKECRMV
                                     ::. : :. .. ..: : :  . .  :  :
NP_001 AGVLGAKEGETCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQSCESNP--NLGYPCNHV
              500       510       520       530         540        

           70                   80        90       100       110   
pF1KB9 QEQCCHSQL-----------EELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCC
       . .::...            :       .: :.   : :   : .: :  ..       :
NP_001 MLSCCEGEEPLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDEC
      550       560       570       580       590       600        

           120       130                     140       150         
pF1KB9 LLGRAAQAQGQSCEYSLM--VG-YQC-----------GQVFRACCVKSQETGDLDVGGLQ
       ::       :. :..  .  :: :.:           :.. :      :  .  . .  .
NP_001 LL-----LPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS
      610            620       630       640       650       660   

     160       170       180       190       200       210         
pF1KB9 ETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCED---
       : ...         :  :  :. .::::: :  .:  ..:::: :: ...:::::::   
NP_001 EFSQVASNTIPLPLPQPNT-CKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDE
           670       680        690       700       710       720  

                                                    220       230  
pF1KB9 --------------------------------------------VNECITGSHSCRLGES
                                                   .:::.:  :.:  :: 
NP_001 CLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEH
            730       740       750       760       770       780  

            240       250       260       270       280       290  
pF1KB9 CINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL
       :.::.:::.: .  .:  :: : .:. :.:.:::  : :.: : :.:::: ::: :. . 
NP_001 CVNTLGSFHCYKALTCEPGYAL-KDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQ
            790       800        810       820       830       840 

            300       310       320       330       340       350  
pF1KB9 QCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGT
       .: .::.::  :::.::::: :.: ::  : .:::: ::::::.:   :.:::: ...::
NP_001 RCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGT
             850       860       870       880       890       900 

            360       370       380       390       400       410  
pF1KB9 RCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCG
       .::::.::   .. ::.:. : : :::.::.::.:.  :...: :.:::::   ::::: 
NP_001 KCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQ
             910       920       930       940       950       960 

            420       430       440       450       460       470  
pF1KB9 HKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLS
       : :::::::: :::. :: :..::. :::.::: .. :::::::.:::::::::.::::.
NP_001 HTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLA
             970       980       990      1000      1010      1020 

            480       490       500       510       520       530  
pF1KB9 DVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTG
       . :: :: ::::::   .: .:..::.:.:::.::.:: .:: .. :::.:.:.:::. :
NP_001 E-DGHTCTDIDECA-QGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALG
             1030       1040      1050      1060      1070         

            540       550       560       570       580       590  
pF1KB9 IHNCSINETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDP
        ::::  ::: ::::.:::: :::: ::      .:  ::   .: ..   . . :  .:
NP_001 THNCSEAETCHNIQGSFRCLRFECPPNY------VQVSKT---KCERTTCHDFLECQNSP
    1080      1090      1100            1110         1120      1130

            600       610       620       630        640       650 
pF1KB9 VHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQANII-FDITEGNLRDSFDIIKRY
       .. :.:  ... :   .  : .:. .     : ::  .. : ..: .:: .  :    : 
NP_001 AR-ITHYQLNFQT--GLLVPAHIFRI----GPAPAFTGDTIALNIIKGNEEGYFG--TRR
              1140        1150          1160      1170        1180 

             660       670       680       690       700   
pF1KB9 MDGMTVGVVRQVRPIVGPFHAVLKLEMNYVVGGVVSHRNVVNVHIFVSEYWF
       ....: :::   : .. :   .: .::.    : :.   ....::: . .  
NP_001 LNAYT-GVVYLQRAVLEPRDFALDVEMKLWRQGSVT-TFLAKMHIFFTTFAL
             1190      1200      1210       1220      1230 

>>NP_001158507 (OMIM: 135821) fibulin-2 isoform a precur  (1231 aa)
 initn: 2090 init1: 1039 opt: 1729  Z-score: 1295.6  bits: 251.0 E(85289): 2e-65
Smith-Waterman score: 1826; 39.5% identity (59.3% similar) in 740 aa overlap (36-701:521-1229)

          10        20        30        40        50         60    
pF1KB9 PSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDC-SLPYATESKECRMV
                                     ::. : :. .. ..: : :  . .  :  :
NP_001 AGVLGAKEGETCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQSCESNP--NLGYPCNHV
              500       510       520       530         540        

           70                   80        90       100       110   
pF1KB9 QEQCCHSQL-----------EELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCC
       . .::...            :       .: :.   : :   : .: :  ..       :
NP_001 MLSCCEGEEPLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDEC
      550       560       570       580       590       600        

           120       130                     140       150         
pF1KB9 LLGRAAQAQGQSCEYSLM--VG-YQC-----------GQVFRACCVKSQETGDLDVGGLQ
       ::       :. :..  .  :: :.:           :.. :      :  .  . .  .
NP_001 LL-----LPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS
      610            620       630       640       650       660   

     160       170       180       190       200       210         
pF1KB9 ETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCED---
       : ...         :  :  :. .::::: :  .:  ..:::: :: ...:::::::   
NP_001 EFSQVASNTIPLPLPQPNT-CKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDE
           670       680        690       700       710       720  

                                                    220       230  
pF1KB9 --------------------------------------------VNECITGSHSCRLGES
                                                   .:::.:  :.:  :: 
NP_001 CLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEH
            730       740       750       760       770       780  

            240       250       260       270       280       290  
pF1KB9 CINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL
       :.::.:::.: .  .:  :: : .:. :.:.:::  : :.: : :.:::: ::: :. . 
NP_001 CVNTLGSFHCYKALTCEPGYAL-KDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQ
            790       800        810       820       830       840 

            300       310       320       330       340       350  
pF1KB9 QCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGT
       .: .::.::  :::.::::: :.: ::  : .:::: ::::::.:   :.:::: ...::
NP_001 RCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGT
             850       860       870       880       890       900 

            360       370       380       390       400       410  
pF1KB9 RCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCG
       .::::.::   .. ::.:. : : :::.::.::.:.  :...: :.:::::   ::::: 
NP_001 KCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQ
             910       920       930       940       950       960 

            420       430       440       450       460       470  
pF1KB9 HKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLS
       : :::::::: :::. :: :..::. :::.::: .. :::::::.:::::::::.::::.
NP_001 HTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLA
             970       980       990      1000      1010      1020 

            480       490       500       510       520       530  
pF1KB9 DVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTG
       . :: :: ::::::   .: .:..::.:.:::.::.:: .:: .. :::.:.:.:::. :
NP_001 E-DGHTCTDIDECA-QGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALG
             1030       1040      1050      1060      1070         

            540       550       560       570       580       590  
pF1KB9 IHNCSINETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDP
        ::::  ::: ::::.:::: :::: ::      .:  ::   .: ..   . . :  .:
NP_001 THNCSEAETCHNIQGSFRCLRFECPPNY------VQVSKT---KCERTTCHDFLECQNSP
    1080      1090      1100            1110         1120      1130

            600       610       620       630        640       650 
pF1KB9 VHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQANII-FDITEGNLRDSFDIIKRY
       .. :.:  ... :   .  : .:. .     : ::  .. : ..: .:: .  :    : 
NP_001 AR-ITHYQLNFQT--GLLVPAHIFRI----GPAPAFTGDTIALNIIKGNEEGYFG--TRR
              1140        1150          1160      1170        1180 

             660       670       680       690       700   
pF1KB9 MDGMTVGVVRQVRPIVGPFHAVLKLEMNYVVGGVVSHRNVVNVHIFVSEYWF
       ....: :::   : .. :   .: .::.    : :.   ....::: . .  
NP_001 LNAYT-GVVYLQRAVLEPRDFALDVEMKLWRQGSVT-TFLAKMHIFFTTFAL
             1190      1200      1210       1220      1230 

>>XP_006713089 (OMIM: 135821) PREDICTED: fibulin-2 isofo  (1192 aa)
 initn: 2094 init1: 870 opt: 1308  Z-score: 983.9  bits: 193.3 E(85289): 4.6e-48
Smith-Waterman score: 1518; 35.4% identity (54.9% similar) in 740 aa overlap (36-701:521-1190)

          10        20        30        40        50         60    
pF1KB9 PSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDC-SLPYATESKECRMV
                                     ::. : :. .. ..: : :  . .  :  :
XP_006 AGVLGAKEGETCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQSCESNP--NLGYPCNHV
              500       510       520       530         540        

           70                   80        90       100       110   
pF1KB9 QEQCCHSQL-----------EELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCC
       . .::...            :       .: :.   : :   : .: :  ..       :
XP_006 MLSCCEGEEPLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDEC
      550       560       570       580       590       600        

           120       130                     140       150         
pF1KB9 LLGRAAQAQGQSCEYSLM--VG-YQC-----------GQVFRACCVKSQETGDLDVGGLQ
       ::       :. :..  .  :: :.:           :.. :      :  .  . .  .
XP_006 LL-----LPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS
      610            620       630       640       650       660   

     160       170       180       190       200       210         
pF1KB9 ETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCED---
       : ...         :  :  :. .::::: :  .:  ..:::: :: ...:::::::   
XP_006 EFSQVASNTIPLPLPQPNT-CKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDE
           670       680        690       700       710       720  

                                                    220       230  
pF1KB9 --------------------------------------------VNECITGSHSCRLGES
                                                   .:::.:  :.:  :: 
XP_006 CLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEH
            730       740       750       760       770       780  

            240       250       260       270       280       290  
pF1KB9 CINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL
       :.::.:::.: .  .:  :: : .:. :.:.:::  : :.: : :.:::: ::: :. . 
XP_006 CVNTLGSFHCYKALTCEPGYAL-KDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQ
            790       800        810       820       830       840 

            300       310       320       330       340       350  
pF1KB9 QCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGT
       .: .::.::  :::.::::: :.: ::  : .:::: ::::::.:   :.:::: ...::
XP_006 RCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGT
             850       860       870       880       890       900 

            360       370       380       390       400       410  
pF1KB9 RCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCG
       .::::.::   .. ::.:. : : :::.::.::.:.  :...: :.:::::   ::::: 
XP_006 KCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQ
             910       920       930       940       950       960 

            420       430       440       450       460       470  
pF1KB9 HKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLS
       : :::::::: :::. :: :..::. ::::.::...                        
XP_006 HTCENTLGSYRCSCASGFLLAADGKRCEDIDECAQG------------------------
             970       980       990                               

            480       490       500       510       520       530  
pF1KB9 DVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTG
                        .: .:..::.:.:::.::.:: .:: .. :::.:.:.:::. :
XP_006 -----------------AGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALG
                       1000      1010      1020      1030      1040

            540       550       560       570       580       590  
pF1KB9 IHNCSINETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDP
        ::::  ::: ::::.:::: :::: ::      .:  ::   .: ..   . . :  .:
XP_006 THNCSEAETCHNIQGSFRCLRFECPPNY------VQVSKT---KCERTTCHDFLECQNSP
             1050      1060            1070         1080      1090 

            600       610       620       630        640       650 
pF1KB9 VHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQANII-FDITEGNLRDSFDIIKRY
       .. :.:  ... :   .  : .:. .     : ::  .. : ..: .:: .  :    : 
XP_006 AR-ITHYQLNFQT--GLLVPAHIFRI----GPAPAFTGDTIALNIIKGNEEGYFG--TRR
             1100        1110          1120      1130        1140  

             660       670       680       690       700   
pF1KB9 MDGMTVGVVRQVRPIVGPFHAVLKLEMNYVVGGVVSHRNVVNVHIFVSEYWF
       ....: :::   : .. :   .: .::.    : :.   ....::: . .  
XP_006 LNAYT-GVVYLQRAVLEPRDFALDVEMKLWRQGSVT-TFLAKMHIFFTTFAL
            1150      1160      1170       1180      1190  

>>XP_011525684 (OMIM: 604710,613177) PREDICTED: latent-t  (1554 aa)
 initn: 666 init1: 369 opt: 749  Z-score: 568.6  bits: 116.9 E(85289): 6.2e-25
Smith-Waterman score: 910; 37.5% identity (57.8% similar) in 424 aa overlap (178-588:600-995)

       150       160       170       180         190       200     
pF1KB9 QETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRG-GGPCKQ-QCRDTGDEVVCSCFVGY
                                     :.::    ::   .:...     : :  :.
XP_011 GRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGF
     570       580       590       600       610       620         

         210       220       230       240       250        260    
pF1KB9 QLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDID
       .    .. : ::.::      : ::. : :: ::: :     : .::. .  . ::.:.:
XP_011 RAGPRAAECLDVDECHRVPPPCDLGR-CENTPGSFLC----VCPAGYQAAPHGASCQDVD
     630       640       650        660           670       680    

          270       280       290       300        310       320   
pF1KB9 ECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAPCPIGH
       ::  .   :     :.:: :::.:     :  ::  .. :. : :..:: .  : :: :.
XP_011 ECARSPPPCTYGR-CENTEGSFQCV----CPMGFQPNTAGSECEDVDECENHLA-CP-GQ
          690        700           710       720       730         

           330       340       350       360       370       380   
pF1KB9 TCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCE
        :.:. ::. :.    .:  :.::.. : ::.:::::.  : :::   .:.:. ::::: 
XP_011 ECVNSPGSFQCR----TCPSGHHLHR-G-RCTDVDECSSGAPPCGPHGHCTNTEGSFRCS
       740           750        760        770       780       790 

           390        400       410         420       430       440
pF1KB9 CKTGYYF-DGISRMCVDVNECQRYPGRLC-GH-KCENTLGSYLCSCSVGFRLSVDGRSCE
       :  ::   .:    :.::::: .  : .:  : .: :: ::. :.:. :.: .  : :: 
XP_011 CAPGYRAPSGRPGPCADVNECLE--GDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCL
             800       810         820       830       840         

              450         460       470       480       490        
pF1KB9 DINECSSSPCSQE--CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHIC-SYR
       :..:::     :   :.:. ::..: :  :.. .  : ..: :.:::    :  .: : :
XP_011 DVDECSEEDLCQSGICTNTDGSFECICPPGHR-AGPDLASCLDVDECR-ERGPALCGSQR
     850       860       870       880        890        900       

       500         510       520       530        540       550    
pF1KB9 CINIPGSFQC--SCPSSGYRLAPNGRNCQDIDECVT-GIHNCSINETCFNIQGGFRCLAF
       : : :::..:  .: . ::. .:.: .:.:.:::   : . :.  . : :  :..::   
XP_011 CENSPGSYRCVRDC-DPGYHAGPEG-TCDDVDECQEYGPEICGA-QRCENTPGSYRCTP-
       910       920        930        940        950       960    

          560       570       580       590       600       610    
pF1KB9 ECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTVISLPTFREFTRPEE
        :  .:. . .   :. .:  :  . :  . : :                          
XP_011 ACDPGYQPTPGGGCQD-VDECRNRSFCGAHAV-CQNLPGSFQCLCDQGYEGARDGRHCVD
           970        980       990       1000      1010      1020 

          620       630       640       650       660       670    
pF1KB9 IIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVVRQVRPIVGPFHAVL
                                                                   
XP_011 VNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPA
            1030      1040      1050      1060      1070      1080 

>>XP_016882866 (OMIM: 608529) PREDICTED: fibrillin-3 iso  (1948 aa)
 initn: 599 init1: 236 opt: 744  Z-score: 563.9  bits: 116.3 E(85289): 1.1e-24
Smith-Waterman score: 1004; 34.1% identity (55.8% similar) in 593 aa overlap (19-589:38-568)

                           10        20         30        40       
pF1KB9             MERAAPSRRVPLPLLLLGGLALLAAG-VDADVLLEACCADGHRMATHQ
                                     :: : :.: . .:: :: :      .   .
XP_016 DVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCF-----LRWDE
        10        20        30        40        50             60  

        50        60        70        80        90       100       
pF1KB9 KDCSLPYATESKECRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVK
        .:..   :   . ::  . ::        :. :   . : . :  :.    :::  :..
XP_016 DECGV---TLPGKYRM--DVCC--------CSIGAVWGVECEACPDPE----SLE--FAS
                70                  80        90           100     

       110       120       130       140       150       160       
pF1KB9 RCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEV
        : .   :: :..   ..  .   :. .: .:: . :  .. :    ::... .     .
XP_016 LCPRG--LGFASRDFLSGRPFYKDVN-EC-KVFPGLC--THGTCRNTVGSFHCACAGGFA
             110       120         130         140       150       

       170        180         190       200          210       220 
pF1KB9 EEEQEDPYLN-DRCRGGGP-CKQ-QCRDTGDEVVCSCFVGYQ---LLSDGVSCEDVNECI
        . ::    . :.:: .   : :  : .:     : :: ::.   .:    .: ::.:: 
XP_016 LDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMK--NCMDVDECA
       160       170       180       190       200         210     

             230       240       250        260       270       280
pF1KB9 TGSHSCRLGESCINTVGSFRCQRDSSCGTGYELT-EDNSCKDIDECESGIHNCLPDFICQ
            :: : .: :: ::..::    :  :.::: . ..:.:::::  .   : :   : 
XP_016 RDPLLCR-GGTCTNTDGSYKCQ----CPPGHELTAKGTACEDIDECSLSDGLC-PHGQCV
         220        230           240       250       260          

              290         300       310       320       330        
pF1KB9 NTLGSFRCRPKLQCKSGF--IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNV
       :..:.:.:    .:..::    :  : :.:::::   .. : . : :::::::: :    
XP_016 NVIGAFQC----SCHAGFQSTPDRQG-CVDINECRVQNGGCDV-H-CINTEGSYRC----
     270           280       290        300         310            

      340       350       360       370       380       390        
pF1KB9 PNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV
        .::.:: :  .:  :.:::::    . : .:: :.: ::. :: :  :..     : ::
XP_016 -SCGQGYSLMPDGRACADVDECEENPRVCDQGH-CTNMPGGHRCLCYDGFMATPDMRTCV
       320       330       340       350        360       370      

      400       410        420       430       440         450     
pF1KB9 DVNECQRYPGRLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSSPCSQE--
       ::.::.  : ..: :  :::: ::..: :..:. .   . .: :..::  ..  :...  
XP_016 DVDECDLNP-HICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHAS
        380        390       400       410       420       430     

           460       470       480       490         500       510 
pF1KB9 CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR--CINIPGSFQCSCPS
       : :. ::..: :  :.     ::  :.:.:::.  .  : :: :  :.:.:::..:.:  
XP_016 CLNIPGSFSCRCLPGWVG---DGFECHDLDECV--SQEHRCSPRGDCLNVPGSYRCTC-R
         440       450          460         470       480          

             520       530       540       550          560        
pF1KB9 SGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC---LAFECPENYRRSAATLQ
       .:.  : .:  :.: :::. ..  :. :  :.:  ::.::   ..:. : . .:.   ..
XP_016 QGF--AGDGFFCEDRDECAENVDLCD-NGQCLNAPGGYRCECEMGFD-PTEDHRACQDVD
     490         500       510        520       530        540     

      570       580         590       600       610       620      
pF1KB9 QEKTDTVRCIKSCR--PNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRAITPPHP
       .    ..  . ::.  :.   :.                                     
XP_016 ECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPGS
         550       560       570       580       590       600     

>--
 initn: 405 init1: 234 opt: 775  Z-score: 586.8  bits: 120.5 E(85289): 6e-26
Smith-Waterman score: 870; 30.8% identity (49.9% similar) in 617 aa overlap (60-608:863-1442)

      30        40        50        60            70               
pF1KB9 DVLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQC----CHSQLEELHCA------
                                     ::  .   :    : .:.  ..:       
XP_016 PISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFN
            840       850       860       870       880       890  

       80         90          100        110       120       130   
pF1KB9 -TGISLANEQ-DRCAT---PHGDNAS-LEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVG
        ..: :: :. :.:..   :  .::. ..     ::   :  :    . : .:     ::
XP_016 YNSILLACEDVDECGSRESPCQQNADCINIPGSYRC--KCTRGYKL-SPGGAC-----VG
            900       910       920         930        940         

            140       150       160       170       180        190 
pF1KB9 Y-QCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQ-QCR
         .: ..  .:  .  .  : . . .    . ...  .:   .  :.:    :: .  :.
XP_016 RNECREIPNVC--SHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDEC-DRQPCGNGTCK
          950         960       970       980       990       1000 

             200       210       220        230       240       250
pF1KB9 DTGDEVVCSCFVGYQLLSDGVSCEDVNECITG-SHSCRLGESCINTVGSFRCQRDSSCGT
       .      : :: :. .  .: .: : .:: :  .. ::.:. :.::.:::.:     :  
XP_016 NIIGSYNCLCFPGFVVTHNG-DCVDFDECTTLVGQVCRFGH-CLNTAGSFHCL----CQD
            1010      1020       1030      1040       1050         

               260       270       280       290       300         
pF1KB9 GYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDI
       :.::: :. .: : .:: :   .:::   :::  :::::     :  :: :    .::::
XP_016 GFELTADGKNCVDTNECLSLAGTCLPG-TCQNLEGSFRC----ICPPGF-QVQSDHCIDI
        1060      1070      1080       1090           1100         

     310       320       330       340       350                   
pF1KB9 NECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDE----------
       .::      : .: :: :. ::. :      :  :. :...: :: :. .          
XP_016 DECSEEPNLCLFG-TCTNSPGSFQCL-----CPPGFVLSDNGHRCFDTRQSFCFTRFEAG
    1110      1120       1130           1140      1150      1160   

      360       370                         380        390         
pF1KB9 -CAPPAEPCGKGHRCVNS--PG----------------SFRCECKTGY-YFDGISRMCVD
        :. :        ::  :  ::                .:.  :  :.    : .    :
XP_016 KCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSRED
          1170      1180      1190      1200      1210      1220   

     400       410       420       430       440        450        
pF1KB9 VNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS-SSPCSQ-ECANV
       :::: . ::   .  : :: ::. : :  :. :.  : .: : .::: . ::.:  :.::
XP_016 VNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNV
          1230      1240      1250      1260      1270      1280   

       460       470       480       490       500       510       
pF1KB9 YGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLA
        :...: :  :.. . .  .::::::::.:  .  .:..:: :  ::. :.::. :: : 
XP_016 IGGFECACADGFEPGLM--MTCEDIDECSL--NPLLCAFRCHNTEGSYLCTCPA-GYTLR
          1290      1300        1310        1320      1330         

       520       530        540       550       560       570      
pF1KB9 PNGRNCQDIDECVTGIHNCSI-NETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTV-
        .:  :.:.:::. : ..:   .  : :. : : :.   :: ..:   .. .    :.  
XP_016 EDGAMCRDVDECADGQQDCHARGMECKNLIGTFACV---CPPGMRPLPGSGEGCTDDNEC
     1340      1350      1360      1370         1380      1390     

                   580         590         600       610       620 
pF1KB9 ----------RCIKSCRPNDVTCV--FDPVHTIS--HTVISLPTFREFTRPEEIIFLRAI
                 ::...       :   :.:  :..  : . . : : :             
XP_016 HAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSS
        1400      1410      1420      1430      1440      1450     

             630       640       650       660       670       680 
pF1KB9 TPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVVRQVRPIVGPFHAVLKLEMNYV
                                                                   
XP_016 EAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAH
        1460      1470      1480      1490      1500      1510     

>--
 initn: 533 init1: 202 opt: 723  Z-score: 548.3  bits: 113.4 E(85289): 8.4e-24
Smith-Waterman score: 834; 36.8% identity (57.9% similar) in 399 aa overlap (181-569:1469-1835)

              160       170       180       190       200          
pF1KB9 GDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCS-CFVGYQLLS
                                     :: ::  . :   :  .  . :  :    .
XP_016 CFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTA
     1440      1450      1460      1470      1480      1490        

     210       220       230       240       250          260      
pF1KB9 DGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTED---NSCKDIDEC
       .:   .::.::   .: :  :: :::..:::::.    : .::  : :   ..: :.:::
XP_016 EG---RDVDECRMLAHLCAHGE-CINSLGSFRCH----CQAGY--TPDATATTCLDMDEC
     1500         1510       1520          1530        1540        

        270       280       290       300        310       320     
pF1KB9 ESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTC
        .  . :   :.:.:: ::: :    .:  :.. .  : .: :..:: : .  : .   :
XP_016 SQVPKPC--TFLCKNTKGSFLC----SCPRGYLLEEDGRTCKDLDECTSRQHNCQF--LC
     1550        1560          1570      1580      1590        1600

         330       340       350       360       370       380     
pF1KB9 INTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECK
       .:: :..::.     :  :.  ....  : : :::.    :::   .: :.::::::::.
XP_016 VNTVGAFTCR-----CPPGFTQHHQA--CFDNDECSAQPGPCGAHGHCHNTPGSFRCECH
             1610           1620        1630      1640      1650   

         390       400       410       420       430       440     
pF1KB9 TGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC
        :. . . .. : :::::.  : : : : :.: ::.: :::  ::    .  .: : :::
XP_016 QGFTLVSSGHGCEDVNECDG-PHR-CQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENEC
          1660      1670        1680      1690      1700      1710 

           450        460       470       480       490       500  
pF1KB9 SSSP--C-SQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIP
       . ::  : :  : :. :...: :  :...... :  :...::::   :   ::: : : :
XP_016 ALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALG-GCQEVDECAGRRGP--CSYSCANTP
            1720      1730      1740       1750        1760        

            510       520       530       540       550        560 
pF1KB9 GSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC-LAFECPENY-
       :.: :.::. ::  : .: .: .      : ..   .:  .. .. ..: .    :..  
XP_016 GGFLCGCPQ-GYFRAGQG-HCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRP
     1770       1780       1790      1800      1810      1820      

              570       580       590       600       610       620
pF1KB9 RRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRA
       ::::   .:                                                   
XP_016 RRSAHRDHQVNLATLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQ
       1830      1840      1850      1860      1870      1880      

>--
 initn: 347 init1: 227 opt: 318  Z-score: 248.3  bits: 57.9 E(85289): 4.3e-07
Smith-Waterman score: 446; 32.0% identity (54.0% similar) in 278 aa overlap (294-562:569-825)

           270       280       290       300        310       320  
pF1KB9 DECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQD-ALGNCIDINECLSISAPCPIG
                                     :..:.  : . ::: ::::: .  . : :.
XP_016 RACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECAD-PVNC-IN
      540       550       560       570       580       590        

            330       340       350       360       370       380  
pF1KB9 HTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRC
        .:::: ::: :     .: . ..::  :. :::.       :   .:   ..      :
XP_016 GVCINTPGSYLC-----SCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGIS------C
        600            610       620       630       640           

            390         400       410       420       430       440
pF1KB9 ECKTGYYFDGISRM--CVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCE
         . :    :..:   : ....    : .::    ..:    ::  . ::. .      :
XP_016 SAEIGV---GVTRASCCCSLGRAWGNPCELCPMA-NTTEYRTLCPGGEGFQPNRITVILE
         650          660       670        680       690       700 

                450        460       470       480       490       
pF1KB9 DINECSSSP--CSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSY-
       ::.::.  :  :.  .:.:..::.:: :  ::.::.   . :::::::.  .:  ::.  
XP_016 DIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRI-CEDIDECSTHSG--ICGPG
             710       720       730       740        750          

        500       510       520         530       540       550    
pF1KB9 RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDE--CVTGIHNCSINETCFNIQGGFRCLAF
        : :  :.. : ::.  :  . .: ::.:. .  :    ..   ::  ::.   . : ..
XP_016 TCYNTLGNYTCVCPAE-YLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSY
      760       770        780       790       800       810       

          560       570       580       590       600       610    
pF1KB9 ECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTVISLPTFREFTRPEE
       .  . . :                                                    
XP_016 NIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICI
       820       830       840       850       860       870       




703 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 09:06:16 2016 done: Fri Nov  4 09:06:17 2016
 Total Scan time:  8.880 Total Display time:  0.230

Function used was FASTA [36.3.4 Apr, 2011]
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