Result of FASTA (omim) for pF1KB9870
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB9870, 477 aa
  1>>>pF1KB9870 477 - 477 aa - 477 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 4.8270+/-0.000373; mu= 20.9509+/- 0.023
 mean_var=93.0538+/-21.727, 0's: 0 Z-trim(114.7): 499  B-trim: 2586 in 2/49
 Lambda= 0.132956
 statistics sampled from 24022 (24706) to 24022 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.655), E-opt: 0.2 (0.29), width:  16
 Scan time:  9.370

The best scores are:                                      opt bits E(85289)
NP_000789 (OMIM: 126453,143465,606798) D(1B) dopam ( 477) 3285 640.8 2.4e-183
NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 1045 211.1 5.1e-54
NP_000855 (OMIM: 182133) 5-hydroxytryptamine recep ( 377)  553 116.6 1.2e-25
NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572)  500 106.7 1.8e-22
NP_000675 (OMIM: 109630,607276) beta-1 adrenergic  ( 477)  478 102.4   3e-21
NP_000854 (OMIM: 182131) 5-hydroxytryptamine recep ( 390)  469 100.5 8.6e-21
NP_000016 (OMIM: 109691,601665) beta-3 adrenergic  ( 408)  464 99.6 1.7e-20
XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331)  457 98.2 3.8e-20
NP_000859 (OMIM: 312861) 5-hydroxytryptamine recep ( 458)  457 98.3 4.7e-20
NP_001243689 (OMIM: 312861) 5-hydroxytryptamine re ( 458)  457 98.3 4.7e-20
XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328)  454 97.6 5.6e-20
NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520)  456 98.2 5.8e-20
XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366)  454 97.6 6.1e-20
XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389)  454 97.7 6.3e-20
XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402)  454 97.7 6.4e-20
XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556)  454 97.8 7.9e-20
XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308)  444 95.6   2e-19
XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317)  444 95.6 2.1e-19
XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324)  444 95.7 2.1e-19
NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342)  444 95.7 2.2e-19
NP_387512 (OMIM: 126451,181500,190300) D(3) dopami ( 367)  444 95.7 2.3e-19
NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370)  444 95.7 2.3e-19
NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372)  444 95.7 2.3e-19
XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429)  444 95.8 2.5e-19
NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429)  444 95.8 2.5e-19
NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455)  444 95.8 2.6e-19
NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466)  444 95.8 2.7e-19
XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475)  444 95.9 2.7e-19
XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475)  444 95.9 2.7e-19
NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475)  444 95.9 2.7e-19
XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475)  444 95.9 2.7e-19
NP_057658 (OMIM: 126450,159900) D(2) dopamine rece ( 414)  417 90.6   9e-18
NP_000515 (OMIM: 109760,614674) 5-hydroxytryptamin ( 422)  417 90.6 9.1e-18
NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359)  416 90.3 9.4e-18
NP_000786 (OMIM: 126450,159900) D(2) dopamine rece ( 443)  417 90.6 9.4e-18
XP_016872785 (OMIM: 126450,159900) PREDICTED: D(2) ( 443)  417 90.6 9.4e-18
XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362)  416 90.3 9.4e-18
NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465)  417 90.7 9.7e-18
NP_001124527 (OMIM: 142703) histamine H2 receptor  ( 397)  416 90.4   1e-17
XP_005265961 (OMIM: 142703) PREDICTED: histamine H ( 422)  416 90.4   1e-17
XP_011532850 (OMIM: 142703) PREDICTED: histamine H ( 422)  416 90.4   1e-17
XP_016864915 (OMIM: 142703) PREDICTED: histamine H ( 422)  416 90.4   1e-17
XP_011532851 (OMIM: 142703) PREDICTED: histamine H ( 422)  416 90.4   1e-17
XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422)  416 90.4   1e-17
NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413)  414 90.0 1.3e-17
NP_000862 (OMIM: 601109) 5-hydroxytryptamine recep ( 440)  404 88.1 5.3e-17
NP_000674 (OMIM: 104250) alpha-2C adrenergic recep ( 462)  400 87.4 9.2e-17
NP_001035262 (OMIM: 602164) 5-hydroxytryptamine re ( 360)  396 86.5 1.3e-16
NP_001309139 (OMIM: 182134) 5-hydroxytryptamine re ( 366)  396 86.5 1.4e-16
NP_001309138 (OMIM: 182134) 5-hydroxytryptamine re ( 366)  396 86.5 1.4e-16


>>NP_000789 (OMIM: 126453,143465,606798) D(1B) dopamine   (477 aa)
 initn: 3285 init1: 3285 opt: 3285  Z-score: 3412.5  bits: 640.8 E(85289): 2.4e-183
Smith-Waterman score: 3285; 100.0% identity (100.0% similar) in 477 aa overlap (1-477:1-477)

               10        20        30        40        50        60
pF1KB9 MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 VCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFD
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 IMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNW
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 HRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 HRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 MIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSV
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB9 IMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB9 FNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTP
              370       380       390       400       410       420

              430       440       450       460       470       
pF1KB9 GNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
              430       440       450       460       470       

>>NP_000785 (OMIM: 126449) D(1A) dopamine receptor [Homo  (446 aa)
 initn: 1627 init1: 784 opt: 1045  Z-score: 1090.7  bits: 211.1 E(85289): 5.1e-54
Smith-Waterman score: 1647; 58.2% identity (79.1% similar) in 450 aa overlap (40-477:23-444)

      10        20        30        40        50        60         
pF1KB9 AYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSR
                                     ...:::.:.:::. :::::.:::::..: :
NP_000         MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFR
                       10        20        30        40        50  

      70        80        90       100       110       120         
pF1KB9 HLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASIL
       :::...:: :..:::::::.::.::::::::::.::.::::.::..::::::::::::::
NP_000 HLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASIL
             60        70        80        90       100       110  

     130       140       150       160       170       180         
pF1KB9 NLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWG
       :::::::::::::: ::::.:::: . :......:::::.:::::::::.::. . .:  
NP_000 NLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTS--
            120       130       140       150       160       170  

     190       200       210       220       230       240         
pF1KB9 GLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIY
           :.. .: :   : .       .::::::.::::::::.::::::::::::::::::
NP_000 ----PSD-GNATSLAETI-------DNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIY
                   180              190       200       210        

     250       260       270              280       290       300  
pF1KB9 RIAQVQIRRISSLERAAEHAQSCRSSAA------CA-PDTSLRASIKKETKVLKTLSVIM
       :::: :::::..::::: ::..:.....      :. :..:.. :.:.::::::::::::
NP_000 RIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIM
      220       230       240       250       260       270        

            310       320       330       340       350       360  
pF1KB9 GVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFN
       :::::::::::::::..::: :  :  :  : :.. .:::::::::::::::::.:::::
NP_000 GVFVCCWLPFFILNCILPFC-GSGETQP--F-CIDSNTFDVFVWFGWANSSLNPIIYAFN
      280       290        300          310       320       330    

            370       380         390          400       410       
pF1KB9 ADFQKVFAQLLGCSHFCSRT--PVETVNISNE---LISYNQDIVFHKEIAAAYIHMMPNA
       :::.:.:. :::: ..:  :   .:::.:.:.   ..: ...           ....:.:
NP_000 ADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHA
          340       350       360       370       380       390    

       420       430       440       450       460       470       
pF1KB9 VTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
       :  :. :  . :: . . : ..  . ::     : ::  :: . ..::.:: :.: :: :
NP_000 V--GSSEDLKKEEAAGIARPLE--KLSP-----ALSVI-LDYDTDVSLEKIQPITQNGQH
            400       410              420        430       440    

NP_000 PT
         

>>NP_000855 (OMIM: 182133) 5-hydroxytryptamine receptor   (377 aa)
 initn: 608 init1: 239 opt: 553  Z-score: 581.5  bits: 116.6 E(85289): 1.2e-25
Smith-Waterman score: 597; 31.7% identity (59.8% similar) in 410 aa overlap (1-373:1-371)

               10        20        30          40        50        
pF1KB9 MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPP--LGPSQVVTACLLTLLIIWTLLGN
       : : .... . : : :  ..:   ::.  : .  :  :   ..  : .:... . :.:.:
NP_000 MSPLNQSAEGLP-QEASNRSL---NATETSEAWDPRTLQALKISLAVVLSVITLATVLSN
               10         20           30        40        50      

       60        70        80        90       100       110        
pF1KB9 VLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGA-FCDVWV
       ..: ..:. .:.:..  .: .: :::..::.:..:::: . .  ..  : ::  .::.:.
NP_000 AFVLTTILLTRKLHTP-ANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWL
         60        70         80        90       100       110     

       120       130       140       150       160       170       
pF1KB9 AFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQ
       . :: : :::::.::::..::::::.  ..:... :   : .:....:..:: ::. :  
NP_000 SSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPP--
         120       130       140       150       160       170     

       180       190       200       210       220       230       
pF1KB9 LNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIP
       : :.. .:      .. . :.:                   :..  .:.: :.  .::::
NP_000 LFWRQAKAQE----EMSDCLVN------------------TSQI--SYTIYSTCGAFYIP
           180           190                           200         

       240       250               260       270                   
pF1KB9 VAIMIVTYTRIYRIAQVQI--------RRISSLERAAEHAQS--C---------RSSAAC
        ...:. : :::: :. .:        .:... .  .  : :  :         .: .: 
NP_000 SVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAG
     210       220       230       240       250       260         

      280                     290       300       310       320    
pF1KB9 AP-----------DTSL---RASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSG
       .:           :..:   : :  .: :. : :..:.:.:. ::::::... ..:.:  
NP_000 SPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRD
     270       280       290       300       310       320         

          330       340       350       360        370       380   
pF1KB9 HPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYA-FNADFQKVFAQLLGCSHFCSRTP
            ::         :: :.:.:. :: .::.::. :: .:...: ...          
NP_000 SCWIHPA--------LFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS    
     330               340       350       360       370           

           390       400       410       420       430       440   
pF1KB9 VETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQT

>>NP_000669 (OMIM: 104219) alpha-1D adrenergic receptor   (572 aa)
 initn: 636 init1: 241 opt: 500  Z-score: 524.5  bits: 106.7 E(85289): 1.8e-22
Smith-Waterman score: 678; 34.3% identity (63.9% similar) in 385 aa overlap (24-381:78-423)

                      10        20        30          40        50 
pF1KB9        MLPPGSNGTAYPGQFALYQQLAQGNAVGGSA--GAPPLGPSQVVTACLLTLLI
                                     :. :.:.:  :.  .. . : .. .:. .:
NP_000 GGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFI
        50        60        70        80        90       100       

              60        70        80        90       100       110 
pF1KB9 IWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-
       . .. ::.::  ... .:::.. .:: :::.:::.::...  :.:..:. :: :.: :: 
NP_000 LMAVAGNLLVILSVACNRHLQT-VTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGR
       110       120        130       140       150       160      

              120       130       140       150       160       170
pF1KB9 AFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSIL
       ::::::.: :..: :::::.::.:::::: .. . ..:   ::.: : ....: :.....
NP_000 AFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALV
        170       180       190       200       210       220      

              180       190       200       210       220       230
pF1KB9 ISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSS
       .:  :. :.:..           :      .: .: :         :  . .  ::. ::
NP_000 VSVGPL-LGWKE-----------P------VPPDERF---------CGITEEAGYAVFSS
        230                         240                250         

              240       250        260       270             280   
pF1KB9 LISFYIPVAIMIVTYTRIYRIAQVQIRRI-SSLERAAEHAQS------CRSSAACAPDT-
       . :::.:.:...: : :.: .:.   : . ....:   .:.       ::..:. :  . 
NP_000 VCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAH
     260       270       280       290       300       310         

                           290       300       310       320       
pF1KB9 --------SLRASIK-------KETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPE
               ..:.:..       .: :. :::....:::: ::.:::..   .:. :  :.
NP_000 GMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFV---LPLGSLFPQ
     320       330       340       350       360          370      

       330       340       350       360        370       380      
pF1KB9 GPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNA-DFQKVFAQLLGCSHFCSRTPVET
         :      :: .: :. :.:. :: .::.::  .. .:...: .:: :.  : :     
NP_000 LKP------SEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQ--CRRRRRRR
              380       390       400       410       420          

        390       400       410       420       430       440      
pF1KB9 VNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPD
                                                                   
NP_000 PLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRR
      430       440       450       460       470       480        

>>NP_000675 (OMIM: 109630,607276) beta-1 adrenergic rece  (477 aa)
 initn: 399 init1: 287 opt: 478  Z-score: 502.6  bits: 102.4 E(85289): 3e-21
Smith-Waterman score: 752; 36.1% identity (59.9% similar) in 421 aa overlap (8-381:9-399)

                10        20        30                      40     
pF1KB9  MLPPGSNGTAYPGQFALYQQLAQGNAVGGS---AGAPP---LGP--------SQVVTA-
               :.. ::...    : .: :...     ..::   : :        ::  :: 
NP_000 MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG
               10        20        30        40        50        60

             50        60        70        80        90       100  
pF1KB9 --CLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAE
          :..:...  . ::::: .::... .:.. .::.::.::: .:: ..:::.:. :.  
NP_000 MGLLMALIVLLIVAGNVLVIVAIAKTPRLQT-LTNLFIMSLASADLVMGLLVVPFGATIV
               70        80        90        100       110         

            110        120       130       140       150       160 
pF1KB9 VAGYWPFGAF-CDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMV
       : : : .:.: :..:.. :..: :::: .::::..::: ::. ::::.  .:.  :  .:
NP_000 VWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLV
     120       130       140       150       160       170         

             170       180       190       200       210       220 
pF1KB9 GLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSL
         .:..: :.::.:. ..: : ..      :      :         .:    . ::   
NP_000 CTVWAISALVSFLPILMHWWRAES------DEARRCYN---------DP----KCCDFVT
     180       190       200             210                    220

             230       240       250       260            270      
pF1KB9 NRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLER-----AAEHAQSCRS--
       ::.:::.::..:::.:. ::  .: :..: :: :...:.: ::      :.  .   :  
NP_000 NRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPV
              230       240       250       260       270       280

                        280       290               300       310  
pF1KB9 --------------SAACAPDTSLRASIKK--------ETKVLKTLSVIMGVFVCCWLPF
                     .:: :: .. ::. ..        : :.::::..:::::. :::::
NP_000 PAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPF
              290       300       310       320       330       340

            320       330       340       350       360       370  
pF1KB9 FILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQL
       :. : .  :   : :  :       .  :  : :.:.:::..::.::  . ::.:.:  :
NP_000 FLANVVKAF---HRELVP-------DRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGL
                 350              360       370       380       390

            380       390       400       410       420       430  
pF1KB9 LGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEG
       : :..  .:                                                   
NP_000 LCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAG
              400       410       420       430       440       450

>>NP_000854 (OMIM: 182131) 5-hydroxytryptamine receptor   (390 aa)
 initn: 572 init1: 240 opt: 469  Z-score: 494.3  bits: 100.5 E(85289): 8.6e-21
Smith-Waterman score: 607; 32.9% identity (59.5% similar) in 410 aa overlap (3-373:12-384)

                        10        20        30         40        50
pF1KB9          MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLG-PSQVVTACLLTLL
                  ::... :  : :  : .  .:. ..        .. : .:. . ::.:.
NP_000 MEEPGAQCAPPPPAGSETWVP-QANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALI
               10        20         30        40        50         

               60        70        80        90       100       110
pF1KB9 IIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFG
        . : :.:..: :.. :.:.:..  .: .:.::::.::.:..:::: ...  :.: : .:
NP_000 TLATTLSNAFVIATVYRTRKLHTP-ANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLG
      60        70        80         90       100       110        

               120       130       140       150       160         
pF1KB9 -AFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSI
        . :: :.. :: : :::::.::::..::::::.   .:. : : . : ::..:.:..::
NP_000 QVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSI
      120       130       140       150       160       170        

     170       180       190       200       210       220         
pF1KB9 LISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISS
        ::. :  . :.. .:                  ::.  :  ::...        :.. :
NP_000 SISLPP--FFWRQAKA------------------EEEVSECVVNTDHI------LYTVYS
      180         190                         200             210  

     230       240            250        260       270             
pF1KB9 SLISFYIPVAIMIVTYTRIY-----RI-AQVQIRRISSLERAAEHAQSCRSSAACA----
       .. .::.:. ..:. : :::     ::  :.  :  . : ::   ..:  :... .    
NP_000 TVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINS
            220       230       240       250       260       270  

       280                              290       300       310    
pF1KB9 --PDT-------------SLRAS----------IKKETKVLKTLSVIMGVFVCCWLPFFI
         ::.             ..:.:            .: :. :::..:.:.:. :::::::
NP_000 RVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFI
            280       290       300       310       320       330  

          320       330        340       350       360        370  
pF1KB9 LNCMVPFCSGHPEGPPAGFPC-VSETTFDVFVWFGWANSSLNPVIYAF-NADFQKVFAQL
       .. ..:.:.           :    . :: :.:.:. :: .::.::.. : ::...: .:
NP_000 ISLVMPICKD---------ACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKL
            340                350       360       370       380   

            380       390       400       410       420       430  
pF1KB9 LGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEG
       .                                                           
NP_000 IRFKCTS                                                     
           390                                                     

>>NP_000016 (OMIM: 109691,601665) beta-3 adrenergic rece  (408 aa)
 initn: 377 init1: 269 opt: 464  Z-score: 488.9  bits: 99.6 E(85289): 1.7e-20
Smith-Waterman score: 654; 33.0% identity (60.8% similar) in 400 aa overlap (1-381:1-365)

                10        20        30        40        50         
pF1KB9 MLP-PGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNV
       : : :  :..  :  .     :: ..:  ...: : .    .... ::.: .. :. ::.
NP_000 MAPWPHENSSLAP--WPDLPTLAPNTA--NTSGLPGVPWEAALAGALLALAVLATVGGNL
               10          20          30        40        50      

      60        70        80        90       100       110         
pF1KB9 LVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAF-CDVWVA
       :: .::. . .:.. :::::..:::..:: ..:::.:  :.  ..:.::.::  :..:..
NP_000 LVIVAIAWTPRLQT-MTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTS
         60        70         80        90       100       110     

      120       130       140       150       160       170        
pF1KB9 FDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQL
        :..: :::: .::...:::: :.. :.::   .:.: : . : :.:..:  .:: :.. 
NP_000 VDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMS
         120       130       140       150       160       170     

      180       190       200       210       220       230        
pF1KB9 NWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPV
       .: :       : :   .  . .:            . :  . :  :.. :: .:::.:.
NP_000 QWWRV------GADAEAQRCHSNP------------RCCAFASNMPYVLLSSSVSFYLPL
         180             190                   200       210       

      240       250              260       270         280         
pF1KB9 AIMIVTYTRIYRIAQVQIR-------RISSLERAAEHAQSCRSS--AACAPDTSLRASIK
        .:. .:.:.. .:  :.:       :.   :     ..:   .  ..:::  .. :  .
NP_000 LVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGR
       220       230       240       250       260       270       

     290               300       310       320       330       340 
pF1KB9 K--------ETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTF
       .        : ..: ::..:::.:. ::::::. : .  .      : :.  :     .:
NP_000 RPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRAL------GGPSLVPG---PAF
       280       290       300       310             320           

             350       360       370       380       390       400 
pF1KB9 DVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIV
        .. :.:.:::..::.::  . ::...: .:: :   :.:                    
NP_000 LALNWLGYANSAFNPLIYCRSPDFRSAFRRLL-CR--CGRRLPPEPCAAARPALFPSGVP
      330       340       350       360          370       380     

             410       420       430       440       450       460 
pF1KB9 FHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEG
                                                                   
NP_000 AARSSPAQPRLCQRLDGASWGVS                                     
         390       400                                             

>>XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B adrene  (331 aa)
 initn: 550 init1: 236 opt: 457  Z-score: 482.7  bits: 98.2 E(85289): 3.8e-20
Smith-Waterman score: 551; 32.2% identity (62.4% similar) in 351 aa overlap (2-328:5-325)

                  10        20          30        40         50    
pF1KB9    MLPPGSNGTAYPGQFALYQQ--LAQGNAVGGSAGAPPLGPSQVVTACL-LTLLIIWT
           :  : : .: :....  ..  ..  : .....  : :  ...... : :  .:...
XP_006 MNPDLDTGHNTSA-PAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFA
               10         20        30        40        50         

           60        70        80        90       100       110    
pF1KB9 LLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFC
       ..::.::  ... .::::.  :: :::.::..::.... :.:..:. :: ::: .:  ::
XP_006 IVGNILVILSVACNRHLRTP-TNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFC
      60        70         80        90       100       110        

           120       130       140       150       160       170   
pF1KB9 DVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISF
       :.:.: :..: :::::.::.::.::: ..   ..:   .:.: :.. .  .:.:: .::.
XP_006 DIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISI
      120       130       140       150       160       170        

           180       190       200       210       220       230   
pF1KB9 IPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLIS
        :. :.: .. :        ::.         :        ..:  . .  ::. ::: :
XP_006 GPL-LGW-KEPA--------PND---------D--------KECGVTEEPFYALFSSLGS
      180                 190                        200       210 

           240       250       260                      270        
pF1KB9 FYIPVAIMIVTYTRIYRIAQVQIRRISS-----LERAAE----------HAQSCRSSAAC
       ::::.:...: : :.: .:.   . . .     .  . :          : ..  :. : 
XP_006 FYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAK
             220       230       240       250       260       270 

        280          290       300       310       320       330   
pF1KB9 A--PDTSLRASI---KKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGF
       .  : .:. ...   ..: :. :::....:.:. :::::::   .  : :  :.:     
XP_006 GHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLELFTST-PKGLEKDW
             280       290       300       310       320        330

           340       350       360       370       380       390   
pF1KB9 PCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNEL
                                                                   
XP_006 K                                                           
                                                                   

>>NP_000859 (OMIM: 312861) 5-hydroxytryptamine receptor   (458 aa)
 initn: 476 init1: 182 opt: 457  Z-score: 481.0  bits: 98.3 E(85289): 4.7e-20
Smith-Waterman score: 511; 29.2% identity (57.4% similar) in 390 aa overlap (25-383:39-393)

                     10        20        30        40        50    
pF1KB9       MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWT
                                     :.  :.    : :  :   :  ....:: :
NP_000 HSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDG-VQNWPALSIVIIIIMT
       10        20        30        40        50         60       

           60        70        80        90       100        110   
pF1KB9 LLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGY-WPFGAF-
       . ::.::  :.   ..:. : :: :..:::..:..:.::::: . .: .  : ::.  . 
NP_000 IGGNILVIMAVSMEKKLH-NATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYL
        70        80         90       100       110       120      

            120       130       140       150       160       170  
pF1KB9 CDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILIS
       : ::...:.. :::::..::.::.::: ::  :....:  ..  :.. ....:..:: .:
NP_000 CPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVS
        130       140       150       160       170       180      

            180       190       200       210       220        230 
pF1KB9 FIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNR-TYAISSSL
        .:. .   ::.                   :. :    ::  .:   ::  .... .:.
NP_000 -VPIPVIGLRDE-------------------EKVF----VNNTTC--VLNDPNFVLIGSF
         190                          200             210       220

             240       250                              260        
pF1KB9 ISFYIPVAIMIVTYTRIYRIAQVQI-----------------------RRISSLERAAEH
       ..:.::..::..::     . . :                        :  .  : .:. 
NP_000 VAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANP
              230       240       250       260       270       280

      270           280       290       300       310       320    
pF1KB9 AQSC----RSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSG
        :.     :..    :  ...: :..: :. :.:.... ::.  : :::: : .  .:  
NP_000 NQDQNARRRKKKERRPRGTMQA-INNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEK
              290       300        310       320       330         

          330       340       350       360        370       380   
pF1KB9 HPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYA-FNADFQKVFAQLLGCSHFCSRTP
         .        . :  ..::::.:.. :..::..:. ::  ....:.. : :..   . :
NP_000 SCNQK------LMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKP
     340             350       360       370       380       390   

           390       400       410       420       430       440   
pF1KB9 VETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQT
                                                                   
NP_000 PVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSE
           400       410       420       430       440       450   

>>NP_001243689 (OMIM: 312861) 5-hydroxytryptamine recept  (458 aa)
 initn: 476 init1: 182 opt: 457  Z-score: 481.0  bits: 98.3 E(85289): 4.7e-20
Smith-Waterman score: 511; 29.2% identity (57.4% similar) in 390 aa overlap (25-383:39-393)

                     10        20        30        40        50    
pF1KB9       MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWT
                                     :.  :.    : :  :   :  ....:: :
NP_001 HSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDG-VQNWPALSIVIIIIMT
       10        20        30        40        50         60       

           60        70        80        90       100        110   
pF1KB9 LLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGY-WPFGAF-
       . ::.::  :.   ..:. : :: :..:::..:..:.::::: . .: .  : ::.  . 
NP_001 IGGNILVIMAVSMEKKLH-NATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYL
        70        80         90       100       110       120      

            120       130       140       150       160       170  
pF1KB9 CDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILIS
       : ::...:.. :::::..::.::.::: ::  :....:  ..  :.. ....:..:: .:
NP_001 CPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVS
        130       140       150       160       170       180      

            180       190       200       210       220        230 
pF1KB9 FIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNR-TYAISSSL
        .:. .   ::.                   :. :    ::  .:   ::  .... .:.
NP_001 -VPIPVIGLRDE-------------------EKVF----VNNTTC--VLNDPNFVLIGSF
         190                          200             210       220

             240       250                              260        
pF1KB9 ISFYIPVAIMIVTYTRIYRIAQVQI-----------------------RRISSLERAAEH
       ..:.::..::..::     . . :                        :  .  : .:. 
NP_001 VAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANP
              230       240       250       260       270       280

      270           280       290       300       310       320    
pF1KB9 AQSC----RSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSG
        :.     :..    :  ...: :..: :. :.:.... ::.  : :::: : .  .:  
NP_001 NQDQNARRRKKKERRPRGTMQA-INNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEK
              290       300        310       320       330         

          330       340       350       360        370       380   
pF1KB9 HPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYA-FNADFQKVFAQLLGCSHFCSRTP
         .        . :  ..::::.:.. :..::..:. ::  ....:.. : :..   . :
NP_001 SCNQK------LMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKP
     340             350       360       370       380       390   

           390       400       410       420       430       440   
pF1KB9 VETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQT
                                                                   
NP_001 PVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSE
           400       410       420       430       440       450   




477 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 20:57:08 2016 done: Sat Nov  5 20:57:09 2016
 Total Scan time:  9.370 Total Display time:  0.070

Function used was FASTA [36.3.4 Apr, 2011]
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