Result of FASTA (omim) for pF1KB6359
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB6359, 254 aa
  1>>>pF1KB6359 254 - 254 aa - 254 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.2615+/-0.000411; mu= 15.4650+/- 0.026
 mean_var=67.1866+/-13.305, 0's: 0 Z-trim(110.9): 37  B-trim: 0 in 0/52
 Lambda= 0.156471
 statistics sampled from 19324 (19345) to 19324 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.593), E-opt: 0.2 (0.227), width:  16
 Scan time:  6.700

The best scores are:                                      opt bits E(85289)
NP_005780 (OMIM: 605129) proteasome activator comp ( 254) 1620 374.6 9.6e-104
NP_001253974 (OMIM: 605129) proteasome activator c ( 265) 1545 357.7 1.2e-98
NP_001317158 (OMIM: 605129) proteasome activator c ( 193) 1239 288.5 5.9e-78
NP_789839 (OMIM: 605129) proteasome activator comp ( 267)  879 207.3 2.3e-53
NP_006254 (OMIM: 600654) proteasome activator comp ( 249)  679 162.2 8.3e-40
NP_001268457 (OMIM: 600654) proteasome activator c ( 233)  600 144.3 1.8e-34
NP_788955 (OMIM: 600654) proteasome activator comp ( 250)  600 144.3 1.9e-34
NP_002809 (OMIM: 602161) proteasome activator comp ( 239)  426 105.0 1.2e-22
XP_006720276 (OMIM: 602161) PREDICTED: proteasome  ( 162)  386 95.9 4.7e-20
NP_001268458 (OMIM: 600654) proteasome activator c ( 236)  265 68.7 1.1e-11


>>NP_005780 (OMIM: 605129) proteasome activator complex   (254 aa)
 initn: 1620 init1: 1620 opt: 1620  Z-score: 1983.6  bits: 374.6 E(85289): 9.6e-104
Smith-Waterman score: 1620; 100.0% identity (100.0% similar) in 254 aa overlap (1-254:1-254)

               10        20        30        40        50        60
pF1KB6 MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHS
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 DMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 KVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQIS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 RYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIE
              190       200       210       220       230       240

              250    
pF1KB6 KIKRPRSSNAETLY
       ::::::::::::::
NP_005 KIKRPRSSNAETLY
              250    

>>NP_001253974 (OMIM: 605129) proteasome activator compl  (265 aa)
 initn: 1545 init1: 1545 opt: 1545  Z-score: 1891.8  bits: 357.7 E(85289): 1.2e-98
Smith-Waterman score: 1545; 100.0% identity (100.0% similar) in 241 aa overlap (14-254:25-265)

                          10        20        30        40         
pF1KB6            MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPI
                               ::::::::::::::::::::::::::::::::::::
NP_001 MEKWILKKIKYLQSGGLSASYYSYKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPI
               10        20        30        40        50        60

      50        60        70        80        90       100         
pF1KB6 LNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGML
               70        80        90       100       110       120

     110       120       130       140       150       160         
pF1KB6 KSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVE
              130       140       150       160       170       180

     170       180       190       200       210       220         
pF1KB6 SEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYV
              190       200       210       220       230       240

     230       240       250    
pF1KB6 TLHDMILKNIEKIKRPRSSNAETLY
       :::::::::::::::::::::::::
NP_001 TLHDMILKNIEKIKRPRSSNAETLY
              250       260     

>>NP_001317158 (OMIM: 605129) proteasome activator compl  (193 aa)
 initn: 1239 init1: 1239 opt: 1239  Z-score: 1520.5  bits: 288.5 E(85289): 5.9e-78
Smith-Waterman score: 1239; 100.0% identity (100.0% similar) in 193 aa overlap (62-254:1-193)

              40        50        60        70        80        90 
pF1KB6 NFFPKKLLELDSFLKEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDE
                                     ::::::::::::::::::::::::::::::
NP_001                               MNLPVPDPILLTNSHDGLDGPTYKKRRLDE
                                             10        20        30

             100       110       120       130       140       150 
pF1KB6 CEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGN
               40        50        60        70        80        90

             160       170       180       190       200       210 
pF1KB6 NFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDE
              100       110       120       130       140       150

             220       230       240       250    
pF1KB6 KEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY
       :::::::::::::::::::::::::::::::::::::::::::
NP_001 KEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY
              160       170       180       190   

>>NP_789839 (OMIM: 605129) proteasome activator complex   (267 aa)
 initn: 1606 init1: 879 opt: 879  Z-score: 1079.2  bits: 207.3 E(85289): 2.3e-53
Smith-Waterman score: 1584; 95.1% identity (95.1% similar) in 267 aa overlap (1-254:1-267)

               10        20        30        40        50        60
pF1KB6 MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_789 MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHS
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 DMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_789 DMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIE
               70        80        90       100       110       120

              130                    140       150       160       
pF1KB6 KVKPEIRLLIEKCNT-------------VKMWVQLLIPRIEDGNNFGVSIQEETVAELRT
       :::::::::::::::             ::::::::::::::::::::::::::::::::
NP_789 KVKPEIRLLIEKCNTPSGKGPHICFDLQVKMWVQLLIPRIEDGNNFGVSIQEETVAELRT
              130       140       150       160       170       180

       170       180       190       200       210       220       
pF1KB6 VESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_789 VESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQ
              190       200       210       220       230       240

       230       240       250    
pF1KB6 YVTLHDMILKNIEKIKRPRSSNAETLY
       :::::::::::::::::::::::::::
NP_789 YVTLHDMILKNIEKIKRPRSSNAETLY
              250       260       

>>NP_006254 (OMIM: 600654) proteasome activator complex   (249 aa)
 initn: 672 init1: 473 opt: 679  Z-score: 835.7  bits: 162.2 E(85289): 8.3e-40
Smith-Waterman score: 679; 40.9% identity (74.2% similar) in 252 aa overlap (3-254:2-249)

               10        20        30        40        50        60
pF1KB6 MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHS
         ..:.:. :.. ::: ::: . ...:.:....::::. :::.::::: ::  .:.....
NP_006  MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKA
                10        20        30        40        50         

               70        80        90       100       110       120
pF1KB6 DMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIE
        ...:::::.   ....       .:.  :: ... .  :    : : .. :...: ...
NP_006 PLDIPVPDPVKEKEKEE--RKKQQEKEDKDEKKKGEDEDK--GPPCGPVNCNEKIVVLLQ
      60        70          80        90         100       110     

              130       140       150       160       170       180
pF1KB6 KVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQIS
       ..::::. .::. : :  :.:: ::::::::::::..::..   . .....  ..  :::
NP_006 RLKPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQIS
         120       130       140       150       160       170     

              190       200       210       220       230       240
pF1KB6 RYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIE
       .:.  :.  :.: :: ::: :::. : :.:: :: ..::.. :.:: :..:.:.::::.:
NP_006 KYFSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFE
         180       190       200       210       220       230     

              250    
pF1KB6 KIKRPRSSNAETLY
       :.:.::. .   .:
NP_006 KLKKPRGETKGMIY
         240         

>>NP_001268457 (OMIM: 600654) proteasome activator compl  (233 aa)
 initn: 597 init1: 398 opt: 600  Z-score: 739.7  bits: 144.3 E(85289): 1.8e-34
Smith-Waterman score: 600; 40.5% identity (73.1% similar) in 227 aa overlap (3-229:2-224)

               10        20        30        40        50        60
pF1KB6 MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHS
         ..:.:. :.. ::: ::: . ...:.:....::::. :::.::::: ::  .:.....
NP_001  MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKA
                10        20        30        40        50         

               70        80        90       100       110       120
pF1KB6 DMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIE
        ...:::::.   ....       .:.  :: ... .  :    : : .. :...: ...
NP_001 PLDIPVPDPVKEKEKEE--RKKQQEKEDKDEKKKGEDEDKG--PPCGPVNCNEKIVVLLQ
      60        70          80        90         100       110     

              130       140       150       160       170       180
pF1KB6 KVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQIS
       ..::::. .::. : :  :.:: ::::::::::::..::..   . .....  ..  :::
NP_001 RLKPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQIS
         120       130       140       150       160       170     

              190       200       210       220       230       240
pF1KB6 RYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIE
       .:.  :.  :.: :: ::: :::. : :.:: :: ..::.. :.:: ::           
NP_001 KYFSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYVRRLCYMTSS  
         180       190       200       210       220       230     

              250    
pF1KB6 KIKRPRSSNAETLY

>>NP_788955 (OMIM: 600654) proteasome activator complex   (250 aa)
 initn: 597 init1: 398 opt: 600  Z-score: 739.3  bits: 144.3 E(85289): 1.9e-34
Smith-Waterman score: 600; 40.5% identity (73.1% similar) in 227 aa overlap (3-229:2-224)

               10        20        30        40        50        60
pF1KB6 MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHS
         ..:.:. :.. ::: ::: . ...:.:....::::. :::.::::: ::  .:.....
NP_788  MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKA
                10        20        30        40        50         

               70        80        90       100       110       120
pF1KB6 DMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIE
        ...:::::.   ....       .:.  :: ... .  :    : : .. :...: ...
NP_788 PLDIPVPDPVKEKEKEE--RKKQQEKEDKDEKKKGEDEDKG--PPCGPVNCNEKIVVLLQ
      60        70          80        90         100       110     

              130       140       150       160       170       180
pF1KB6 KVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQIS
       ..::::. .::. : :  :.:: ::::::::::::..::..   . .....  ..  :::
NP_788 RLKPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQIS
         120       130       140       150       160       170     

              190       200       210       220       230       240
pF1KB6 RYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIE
       .:.  :.  :.: :: ::: :::. : :.:: :: ..::.. :.:: ::           
NP_788 KYFSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYVRRQGQGRGGQR
         180       190       200       210       220       230     

              250     
pF1KB6 KIKRPRSSNAETLY 
                      
NP_788 QLSQATHSLTLQARG
         240       250

>>NP_002809 (OMIM: 602161) proteasome activator complex   (239 aa)
 initn: 582 init1: 399 opt: 426  Z-score: 527.3  bits: 105.0 E(85289): 1.2e-22
Smith-Waterman score: 535; 33.6% identity (66.8% similar) in 250 aa overlap (5-254:7-239)

                 10        20        30        40        50        
pF1KB6   MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQI
             .... :.. .:. ::. . .:::...  :.:.:.. :...:.:  ::. :::..
NP_002 MAKPCGVRLSGEARKQVEVFRQNLFQEAEEFLYRFLPQKIIYLNQLLQEDSLNVADLTSL
               10        20        30        40        50        60

       60        70        80        90       100       110        
pF1KB6 HSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDI
       .. ...:.:::     . : ..    .:... .:              :.: .:......
NP_002 RAPLDIPIPDP---PPKDDEMETDKQEKKEVHKC--------------GFLPGNEKVLSL
               70           80        90                     100   

      120       130       140       150       160       170        
pF1KB6 IEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQ
       .  ::::.  : :::  :  :.: :::.:::::.:::.:::... .. .:.... ..   
NP_002 LALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTT
           110       120       130       140       150       160   

      180       190       200       210       220       230        
pF1KB6 ISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKN
       ::.:.  :.  :.: .:  :: :::  : : ::  :  :: .. .::  :. :. .: .:
NP_002 ISKYFSERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSN
           170       180       190       200       210       220   

      240       250    
pF1KB6 IEKIKRPRSSNAETLY
       .:::  :.. .  ..:
NP_002 LEKIVNPKGEEKPSMY
           230         

>>XP_006720276 (OMIM: 602161) PREDICTED: proteasome acti  (162 aa)
 initn: 384 init1: 360 opt: 386  Z-score: 481.0  bits: 95.9 E(85289): 4.7e-20
Smith-Waterman score: 386; 39.5% identity (68.4% similar) in 152 aa overlap (103-254:11-162)

             80        90       100       110       120       130  
pF1KB6 TNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEK
                                     :   :.: .:.......  ::::.  : ::
XP_006                     METDKQEKKEVHKCGFLPGNEKVLSLLALVKPEVWTLKEK
                                   10        20        30        40

            140       150       160       170       180       190  
pF1KB6 CNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSK
       :  :  :.: :::.:::::.:::.:::... .. .:.... ..   ::.:.  :.  :.:
XP_006 CILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGDAVAK
               50        60        70        80        90       100

            200       210       220       230       240       250  
pF1KB6 IAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAET
        .:  :: :::  : : ::  :  :: .. .::  :. :. .: .:.:::  :.. .  .
XP_006 ASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPS
              110       120       130       140       150       160

         
pF1KB6 LY
       .:
XP_006 MY
         

>>NP_001268458 (OMIM: 600654) proteasome activator compl  (236 aa)
 initn: 460 init1: 261 opt: 265  Z-score: 330.9  bits: 68.7 E(85289): 1.1e-11
Smith-Waterman score: 639; 40.9% identity (71.0% similar) in 252 aa overlap (3-254:2-236)

               10        20        30        40        50        60
pF1KB6 MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHS
         ..:.:. :.. ::: ::: . ...:.:....::::. :::.::::: ::  .:.....
NP_001  MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKA
                10        20        30        40        50         

               70        80        90       100       110       120
pF1KB6 DMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIE
        ...:::::.   ....       .:.  :: ... .  :    : : .. :...: ...
NP_001 PLDIPVPDPVKEKEKEE--RKKQQEKEDKDEKKKGEDEDK--GPPCGPVNCNEKIVVLLQ
      60        70          80        90         100       110     

              130       140       150       160       170       180
pF1KB6 KVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQIS
       ..::::. .::. : :  :.:: ::::::::::::..: :             ..  :::
NP_001 RLKPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQLE-------------GFHTQIS
         120       130       140       150                    160  

              190       200       210       220       230       240
pF1KB6 RYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIE
       .:.  :.  :.: :: ::: :::. : :.:: :: ..::.. :.:: :..:.:.::::.:
NP_001 KYFSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFE
            170       180       190       200       210       220  

              250    
pF1KB6 KIKRPRSSNAETLY
       :.:.::. .   .:
NP_001 KLKKPRGETKGMIY
            230      




254 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 18:35:08 2016 done: Fri Nov  4 18:35:09 2016
 Total Scan time:  6.700 Total Display time:  0.010

Function used was FASTA [36.3.4 Apr, 2011]
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