Result of FASTA (omim) for pF1KB4832
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB4832, 422 aa
  1>>>pF1KB4832 422 - 422 aa - 422 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.7605+/-0.000356; mu= 14.8246+/- 0.022
 mean_var=71.8777+/-13.736, 0's: 0 Z-trim(114.3): 62  B-trim: 0 in 0/51
 Lambda= 0.151279
 statistics sampled from 24017 (24079) to 24017 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.661), E-opt: 0.2 (0.282), width:  16
 Scan time:  9.050

The best scores are:                                      opt bits E(85289)
NP_002552 (OMIM: 602836) P2X purinoceptor 5 isofor ( 422) 2863 634.1  2e-181
NP_001191448 (OMIM: 602836) P2X purinoceptor 5 iso ( 421) 2841 629.3 5.5e-180
NP_001191449 (OMIM: 602836) P2X purinoceptor 5 iso ( 398) 2092 465.8 8.5e-131
NP_778255 (OMIM: 602836) P2X purinoceptor 5 isofor ( 397) 2070 461.0 2.4e-129
NP_002551 (OMIM: 600846) P2X purinoceptor 4 isofor ( 388) 1196 270.3 6.1e-72
NP_001248327 (OMIM: 600846) P2X purinoceptor 4 iso ( 341) 1194 269.8 7.4e-72
NP_005437 (OMIM: 608077) P2X purinoceptor 6 isofor ( 441) 1106 250.7 5.6e-66
XP_016884557 (OMIM: 608077) PREDICTED: P2X purinoc ( 393) 1102 249.8 9.2e-66
XP_011528800 (OMIM: 608077) PREDICTED: P2X purinoc ( 539) 1102 249.8 1.2e-65
NP_001243725 (OMIM: 600846) P2X purinoceptor 4 iso ( 404) 1086 246.3 1.1e-64
NP_002549 (OMIM: 600845,609821) P2X purinoceptor 1 ( 399) 1016 231.0 4.2e-60
NP_777362 (OMIM: 600844,608224) P2X purinoceptor 2 ( 404)  998 227.1 6.4e-59
XP_005266213 (OMIM: 600844,608224) PREDICTED: P2X  ( 430)  998 227.1 6.8e-59
XP_016874524 (OMIM: 600844,608224) PREDICTED: P2X  ( 462)  998 227.1 7.2e-59
NP_733782 (OMIM: 600844,608224) P2X purinoceptor 2 ( 471)  998 227.1 7.3e-59
XP_005266212 (OMIM: 600844,608224) PREDICTED: P2X  ( 488)  998 227.1 7.6e-59
NP_733783 (OMIM: 600844,608224) P2X purinoceptor 2 ( 497)  998 227.1 7.7e-59
NP_001269094 (OMIM: 600844,608224) P2X purinocepto ( 349)  994 226.2   1e-58
NP_001153026 (OMIM: 608077) P2X purinoceptor 6 iso ( 415)  981 223.4 8.6e-58
XP_011528802 (OMIM: 608077) PREDICTED: P2X purinoc ( 513)  977 222.5 1.9e-57
XP_011522201 (OMIM: 600845,609821) PREDICTED: P2X  ( 411)  906 207.0 7.2e-53
XP_011522199 (OMIM: 600845,609821) PREDICTED: P2X  ( 419)  902 206.1 1.3e-52
XP_005266211 (OMIM: 600844,608224) PREDICTED: P2X  ( 512)  879 201.1 5.2e-51
XP_011528804 (OMIM: 608077) PREDICTED: P2X purinoc ( 324)  858 196.5 8.4e-50
XP_016884555 (OMIM: 608077) PREDICTED: P2X purinoc ( 425)  858 196.5 1.1e-49
XP_005261876 (OMIM: 608077) PREDICTED: P2X purinoc ( 473)  858 196.5 1.2e-49
XP_011543371 (OMIM: 600843) PREDICTED: P2X purinoc ( 397)  843 193.2 9.7e-49
XP_011543372 (OMIM: 600843) PREDICTED: P2X purinoc ( 397)  843 193.2 9.7e-49
NP_002550 (OMIM: 600843) P2X purinoceptor 3 [Homo  ( 397)  843 193.2 9.7e-49
XP_011543374 (OMIM: 600843) PREDICTED: P2X purinoc ( 323)  833 191.0 3.7e-48
XP_011543373 (OMIM: 600843) PREDICTED: P2X purinoc ( 395)  822 188.7 2.3e-47
XP_011522198 (OMIM: 600845,609821) PREDICTED: P2X  ( 431)  792 182.1 2.3e-45
NP_002553 (OMIM: 602566) P2X purinoceptor 7 [Homo  ( 595)  788 181.3 5.6e-45
NP_777361 (OMIM: 600844,608224) P2X purinoceptor 2 ( 379)  696 161.1 4.2e-39
NP_057402 (OMIM: 600844,608224) P2X purinoceptor 2 ( 447)  696 161.2 4.9e-39
XP_011533088 (OMIM: 600844,608224) PREDICTED: P2X  ( 473)  696 161.2 5.1e-39
XP_016884558 (OMIM: 608077) PREDICTED: P2X purinoc ( 391)  683 158.3 3.1e-38
XP_011536721 (OMIM: 602566) PREDICTED: P2X purinoc ( 491)  653 151.8 3.5e-36
NP_036358 (OMIM: 600844,608224) P2X purinoceptor 2 ( 399)  634 147.6 5.2e-35
XP_016884561 (OMIM: 608077) PREDICTED: P2X purinoc ( 290)  627 146.0 1.1e-34
XP_016884564 (OMIM: 608077) PREDICTED: P2X purinoc ( 290)  627 146.0 1.1e-34
XP_016884562 (OMIM: 608077) PREDICTED: P2X purinoc ( 290)  627 146.0 1.1e-34
XP_016884565 (OMIM: 608077) PREDICTED: P2X purinoc ( 290)  627 146.0 1.1e-34
XP_016884563 (OMIM: 608077) PREDICTED: P2X purinoc ( 290)  627 146.0 1.1e-34
NP_001248326 (OMIM: 600846) P2X purinoceptor 4 iso ( 361)  627 146.1 1.4e-34
XP_011536718 (OMIM: 600846) PREDICTED: P2X purinoc ( 258)  621 144.7 2.6e-34
XP_011528803 (OMIM: 608077) PREDICTED: P2X purinoc ( 388)  623 145.2 2.7e-34
XP_016884559 (OMIM: 608077) PREDICTED: P2X purinoc ( 388)  623 145.2 2.7e-34
XP_016874853 (OMIM: 602566) PREDICTED: P2X purinoc ( 475)  595 139.1 2.2e-32
XP_016874854 (OMIM: 602566) PREDICTED: P2X purinoc ( 475)  595 139.1 2.2e-32


>>NP_002552 (OMIM: 602836) P2X purinoceptor 5 isoform A   (422 aa)
 initn: 2863 init1: 2863 opt: 2863  Z-score: 3378.3  bits: 634.1 E(85289): 2e-181
Smith-Waterman score: 2863; 100.0% identity (100.0% similar) in 422 aa overlap (1-422:1-422)

               10        20        30        40        50        60
pF1KB4 MGQAGCKGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MGQAGCKGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 SLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 NEGIPDGACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSRPEEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NEGIPDGACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSRPEEP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 FLKEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPKNHYCPIFRLGSVIRW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FLKEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPKNHYCPIFRLGSVIRW
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 AGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVSSGYNFRFARY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVSSGYNFRFARY
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 YRDAAGVEFRTLMKAYGIRFDVMVNGKGAFFCDLVLIYLIKKREFYRDKKYEEVRGLEDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 YRDAAGVEFRTLMKAYGIRFDVMVNGKGAFFCDLVLIYLIKKREFYRDKKYEEVRGLEDS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 SQEAEDEASGLGLSEQLTSGPGLLGMPEQQELQEPPEAKRGSSSQKGNGSVCPQLLEPHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SQEAEDEASGLGLSEQLTSGPGLLGMPEQQELQEPPEAKRGSSSQKGNGSVCPQLLEPHR
              370       380       390       400       410       420

         
pF1KB4 ST
       ::
NP_002 ST
         

>>NP_001191448 (OMIM: 602836) P2X purinoceptor 5 isoform  (421 aa)
 initn: 1480 init1: 1480 opt: 2841  Z-score: 3352.3  bits: 629.3 E(85289): 5.5e-180
Smith-Waterman score: 2841; 99.5% identity (99.8% similar) in 422 aa overlap (1-422:1-421)

               10        20        30        40        50        60
pF1KB4 MGQAGCKGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGQAGCKGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 SLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 NEGIPDGACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSRPEEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEGIPDGACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSRPEEP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 FLKEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPKNHYCPIFRLGSVIRW
       :::::::::::::::::::::::: .::::::::::::::::::::::::::::::::::
NP_001 FLKEAEDFTIFIKNHIRFPKFNFS-NNVMDVKDRSFLKSCHFGPKNHYCPIFRLGSVIRW
              190       200        210       220       230         

              250       260       270       280       290       300
pF1KB4 AGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVSSGYNFRFARY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVSSGYNFRFARY
     240       250       260       270       280       290         

              310       320       330       340       350       360
pF1KB4 YRDAAGVEFRTLMKAYGIRFDVMVNGKGAFFCDLVLIYLIKKREFYRDKKYEEVRGLEDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YRDAAGVEFRTLMKAYGIRFDVMVNGKGAFFCDLVLIYLIKKREFYRDKKYEEVRGLEDS
     300       310       320       330       340       350         

              370       380       390       400       410       420
pF1KB4 SQEAEDEASGLGLSEQLTSGPGLLGMPEQQELQEPPEAKRGSSSQKGNGSVCPQLLEPHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQEAEDEASGLGLSEQLTSGPGLLGMPEQQELQEPPEAKRGSSSQKGNGSVCPQLLEPHR
     360       370       380       390       400       410         

         
pF1KB4 ST
       ::
NP_001 ST
     420 

>>NP_001191449 (OMIM: 602836) P2X purinoceptor 5 isoform  (398 aa)
 initn: 2092 init1: 2092 opt: 2092  Z-score: 2469.2  bits: 465.8 E(85289): 8.5e-131
Smith-Waterman score: 2647; 94.3% identity (94.3% similar) in 422 aa overlap (1-422:1-398)

               10        20        30        40        50        60
pF1KB4 MGQAGCKGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGQAGCKGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 SLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAE
       ::::::::::::::::::::::::::::::::::::                        
NP_001 SLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQ------------------------
               70        80        90                              

              130       140       150       160       170       180
pF1KB4 NEGIPDGACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSRPEEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEGIPDGACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSRPEEP
        100       110       120       130       140       150      

              190       200       210       220       230       240
pF1KB4 FLKEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPKNHYCPIFRLGSVIRW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLKEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPKNHYCPIFRLGSVIRW
        160       170       180       190       200       210      

              250       260       270       280       290       300
pF1KB4 AGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVSSGYNFRFARY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVSSGYNFRFARY
        220       230       240       250       260       270      

              310       320       330       340       350       360
pF1KB4 YRDAAGVEFRTLMKAYGIRFDVMVNGKGAFFCDLVLIYLIKKREFYRDKKYEEVRGLEDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YRDAAGVEFRTLMKAYGIRFDVMVNGKGAFFCDLVLIYLIKKREFYRDKKYEEVRGLEDS
        280       290       300       310       320       330      

              370       380       390       400       410       420
pF1KB4 SQEAEDEASGLGLSEQLTSGPGLLGMPEQQELQEPPEAKRGSSSQKGNGSVCPQLLEPHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQEAEDEASGLGLSEQLTSGPGLLGMPEQQELQEPPEAKRGSSSQKGNGSVCPQLLEPHR
        340       350       360       370       380       390      

         
pF1KB4 ST
       ::
NP_001 ST
         

>>NP_778255 (OMIM: 602836) P2X purinoceptor 5 isoform B   (397 aa)
 initn: 2096 init1: 1480 opt: 2070  Z-score: 2443.3  bits: 461.0 E(85289): 2.4e-129
Smith-Waterman score: 2625; 93.8% identity (94.1% similar) in 422 aa overlap (1-422:1-397)

               10        20        30        40        50        60
pF1KB4 MGQAGCKGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_778 MGQAGCKGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 SLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAE
       ::::::::::::::::::::::::::::::::::::                        
NP_778 SLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQ------------------------
               70        80        90                              

              130       140       150       160       170       180
pF1KB4 NEGIPDGACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSRPEEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_778 NEGIPDGACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSRPEEP
        100       110       120       130       140       150      

              190       200       210       220       230       240
pF1KB4 FLKEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPKNHYCPIFRLGSVIRW
       :::::::::::::::::::::::: .::::::::::::::::::::::::::::::::::
NP_778 FLKEAEDFTIFIKNHIRFPKFNFS-NNVMDVKDRSFLKSCHFGPKNHYCPIFRLGSVIRW
        160       170       180        190       200       210     

              250       260       270       280       290       300
pF1KB4 AGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVSSGYNFRFARY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_778 AGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVSSGYNFRFARY
         220       230       240       250       260       270     

              310       320       330       340       350       360
pF1KB4 YRDAAGVEFRTLMKAYGIRFDVMVNGKGAFFCDLVLIYLIKKREFYRDKKYEEVRGLEDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_778 YRDAAGVEFRTLMKAYGIRFDVMVNGKGAFFCDLVLIYLIKKREFYRDKKYEEVRGLEDS
         280       290       300       310       320       330     

              370       380       390       400       410       420
pF1KB4 SQEAEDEASGLGLSEQLTSGPGLLGMPEQQELQEPPEAKRGSSSQKGNGSVCPQLLEPHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_778 SQEAEDEASGLGLSEQLTSGPGLLGMPEQQELQEPPEAKRGSSSQKGNGSVCPQLLEPHR
         340       350       360       370       380       390     

         
pF1KB4 ST
       ::
NP_778 ST
         

>>NP_002551 (OMIM: 600846) P2X purinoceptor 4 isoform 2   (388 aa)
 initn: 1105 init1: 407 opt: 1196  Z-score: 1412.6  bits: 270.3 E(85289): 6.1e-72
Smith-Waterman score: 1246; 50.3% identity (74.0% similar) in 392 aa overlap (4-367:2-388)

                10        20        30        40        50         
pF1KB4 MGQAGC-KGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVD
          :::  .:   ::.: : . :. ...::::. : .:  ::::.. :::. .::::..:
NP_002   MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETD
                 10        20        30        40        50        

      60        70        80        90       100       110         
pF1KB4 TSLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCA
        :. :.: ::::::: :::: :: ::::::::::::: :: .::.::.:.: :: :..: 
NP_002 -SVVSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCP
        60        70        80        90       100       110       

     120         130       140       150       160       170       
pF1KB4 ENEGIPDGA--CSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSR-
       :   :::..  :..:..: :: : : .:::.::::.  .. .. :::. ::::.: ... 
NP_002 E---IPDATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVK-TCEVAAWCPVEDDTHV
          120       130       140       150        160       170   

        180       190       200       210       220        230     
pF1KB4 PEEPFLKEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPK-NHYCPIFRLG
       :.  ::: ::.::...::.: .::::::: :..     ..:::: .  : . .:::::::
NP_002 PQPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLG
           180       190       200       210       220       230   

         240       250       260       270       280        290    
pF1KB4 SVIRWAGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNK-LSKSVSSGYN
       .... :: .:::.:.:::..::...:.:.::.::: : :.::: :::.. . ..:: :::
NP_002 KIVENAGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYN
           240       250       260       270       280       290   

          300       310       320        330                       
pF1KB4 FRFARYYRDAAGVEFRTLMKAYGIRFDVMVNGK-GAF---------------------FC
       ::::.:::: :: : :::.::::::::..: :: : :                     .:
NP_002 FRFAKYYRDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLC
           300       310       320       330       340       350   

            340       350       360       370       380       390  
pF1KB4 DLVLIYLIKKREFYRDKKYEEVRGLEDSSQEAEDEASGLGLSEQLTSGPGLLGMPEQQEL
       :....: .::: .::.:::. :.  :..     :.                         
NP_002 DIIVLYCMKKRLYYREKKYKYVEDYEQGLASELDQ                         
           360       370       380                                 

            400       410       420  
pF1KB4 QEPPEAKRGSSSQKGNGSVCPQLLEPHRST

>>NP_001248327 (OMIM: 600846) P2X purinoceptor 4 isoform  (341 aa)
 initn: 1015 init1: 407 opt: 1194  Z-score: 1411.1  bits: 269.8 E(85289): 7.4e-72
Smith-Waterman score: 1194; 54.5% identity (79.0% similar) in 334 aa overlap (4-331:2-330)

                10        20        30        40        50         
pF1KB4 MGQAGC-KGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVD
          :::  .:   ::.: : . :. ...::::. : .:  ::::.. :::. .::::..:
NP_001   MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETD
                 10        20        30        40        50        

      60        70        80        90       100       110         
pF1KB4 TSLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCA
        :. :.: ::::::: :::: :: ::::::::::::: :: .::.::.:.: :: :..: 
NP_001 -SVVSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCP
        60        70        80        90       100       110       

     120         130       140       150       160       170       
pF1KB4 ENEGIPDGA--CSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSR-
       :   :::..  :..:..: :: : : .:::.::::.  .. .. :::. ::::.: ... 
NP_001 E---IPDATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVK-TCEVAAWCPVEDDTHV
          120       130       140       150        160       170   

        180       190       200       210       220        230     
pF1KB4 PEEPFLKEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPK-NHYCPIFRLG
       :.  ::: ::.::...::.: .::::::: :..     ..:::: .  : . .:::::::
NP_001 PQPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLG
           180       190       200       210       220       230   

         240       250       260       270       280        290    
pF1KB4 SVIRWAGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNK-LSKSVSSGYN
       .... :: .:::.:.:::..::...:.:.::.::: : :.::: :::.. . ..:: :::
NP_001 KIVENAGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYN
           240       250       260       270       280       290   

          300       310       320       330       340       350    
pF1KB4 FRFARYYRDAAGVEFRTLMKAYGIRFDVMVNGKGAFFCDLVLIYLIKKREFYRDKKYEEV
       ::::.:::: :: : :::.::::::::..: ::.. :                       
NP_001 FRFAKYYRDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDITPEKFLESD            
           300       310       320       330       340             

          360       370       380       390       400       410    
pF1KB4 RGLEDSSQEAEDEASGLGLSEQLTSGPGLLGMPEQQELQEPPEAKRGSSSQKGNGSVCPQ

>>NP_005437 (OMIM: 608077) P2X purinoceptor 6 isoform 1   (441 aa)
 initn: 858 init1: 647 opt: 1106  Z-score: 1305.5  bits: 250.7 E(85289): 5.6e-66
Smith-Waterman score: 1156; 44.1% identity (69.6% similar) in 424 aa overlap (2-395:9-423)

                      10          20        30        40        50 
pF1KB4        MGQAGCKGLCLS--LFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLI
               :. :  :   .  :.::::::::...: .:: : :::: .:..:.: :..: 
NP_005 MCPQLAGAGSMGSPGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLA
               10        20        30        40        50        60

              60        70        80        90       100       110 
pF1KB4 KKGYQDVDTSLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTP
       :::::. :   : ..:::.:::. :. ..::.:.:::::.: : :::::::.:::..:::
NP_005 KKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQGENVFFLVTNFLVTP
               70        80        90       100       110       120

             120       130       140       150       160       170 
pF1KB4 NQRQNVCAENEGIPDGACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPL
        : :. : :. ..: . :  : ::  ::. : ..:::::.:.  ..  : ::::..:::.
NP_005 AQVQGRCPEHPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHR-TCEIWSWCPV
              130       140       150       160        170         

             180       190       200       210       220        230
pF1KB4 ETSSRPEEPFLKEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPK-NHYCP
       :..  : .:.: .:..::.:::: . : ::::::::.... : ...: :.. :. . :::
NP_005 ESGVVPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCP
     180       190       200       210       220       230         

              240       250       260       270       280       290
pF1KB4 IFRLGSVIRWAGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVS
       .::.:...  ::. :.:.:: :: .:: ..:.:::: . : : ::::: .:..:      
NP_005 VFRIGDLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSF-QLQEK------
     240       250       260       270       280        290        

              300       310       320                              
pF1KB4 SGYNFRFARYYRDAAGVEFRTLMKAYGIRFDVMVNGK---------------GA------
        .:::: : .. .  ::: :::.: ::::::..:.:.               ::      
NP_005 -SYNFRTATHWWEQPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVV
             300       310       320       330       340       350 

      330       340       350       360          370         380   
pF1KB4 -FFCDLVLIYLIKKREFYRDKKYEEVRGLEDSSQEAEDE---ASGLGLSEQL--TSGPGL
        :::::.:.:. .. .::   ::::... . ... .  :   ::   :.: :  .:.:. 
NP_005 TFFCDLLLLYVDREAHFYWRTKYEEAKAPKATANSVWRELALASQARLAECLRRSSAPAP
             360       370       380       390       400       410 

           390       400       410       420  
pF1KB4 LGMPEQQELQEPPEAKRGSSSQKGNGSVCPQLLEPHRST
        .    .. : :                           
NP_005 TATAAGSQTQTPGWPCPSSDTHLPTHSGSL         
             420       430       440          

>>XP_016884557 (OMIM: 608077) PREDICTED: P2X purinocepto  (393 aa)
 initn: 772 init1: 647 opt: 1102  Z-score: 1301.6  bits: 249.8 E(85289): 9.2e-66
Smith-Waterman score: 1102; 49.2% identity (75.7% similar) in 329 aa overlap (2-327:9-328)

                      10          20        30        40        50 
pF1KB4        MGQAGCKGLCLS--LFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLI
               :. :  :   .  :.::::::::...: .:: : :::: .:..:.: :..: 
XP_016 MCPQLAGAGSMGSPGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLA
               10        20        30        40        50        60

              60        70        80        90       100       110 
pF1KB4 KKGYQDVDTSLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTP
       :::::. :   : ..:::.:::. :. ..::.:.:::::.: : :::::::.:::..:::
XP_016 KKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQGENVFFLVTNFLVTP
               70        80        90       100       110       120

             120       130       140       150       160       170 
pF1KB4 NQRQNVCAENEGIPDGACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPL
        : :. : :. ..: . :  : ::  ::. : ..:::::.:.  ..  : ::::..:::.
XP_016 AQVQGRCPEHPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHR-TCEIWSWCPV
              130       140       150       160        170         

             180       190       200       210       220        230
pF1KB4 ETSSRPEEPFLKEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPK-NHYCP
       :..  : .:.: .:..::.:::: . : ::::::::.... : ...: :.. :. . :::
XP_016 ESGVVPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCP
     180       190       200       210       220       230         

              240       250       260       270       280       290
pF1KB4 IFRLGSVIRWAGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVS
       .::.:...  ::. :.:.:: :: .:: ..:.:::: . : : ::::: .:..:      
XP_016 VFRIGDLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSF-QLQEK------
     240       250       260       270       280        290        

              300       310       320       330       340       350
pF1KB4 SGYNFRFARYYRDAAGVEFRTLMKAYGIRFDVMVNGKGAFFCDLVLIYLIKKREFYRDKK
        .:::: : .. .  ::: :::.: ::::::..:.:.                       
XP_016 -SYNFRTATHWWEQPGVEARTLLKLYGIRFDILVTGQAKAPKATANSVWRELALASQARL
             300       310       320       330       340       350 

              360       370       380       390       400       410
pF1KB4 YEEVRGLEDSSQEAEDEASGLGLSEQLTSGPGLLGMPEQQELQEPPEAKRGSSSQKGNGS
                                                                   
XP_016 AECLRRSSAPAPTATAAGSQTQTPGWPCPSSDTHLPTHSGSL                  
             360       370       380       390                     

>>XP_011528800 (OMIM: 608077) PREDICTED: P2X purinocepto  (539 aa)
 initn: 772 init1: 647 opt: 1102  Z-score: 1299.5  bits: 249.8 E(85289): 1.2e-65
Smith-Waterman score: 1102; 49.2% identity (75.7% similar) in 329 aa overlap (2-327:9-328)

                      10          20        30        40        50 
pF1KB4        MGQAGCKGLCLS--LFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLI
               :. :  :   .  :.::::::::...: .:: : :::: .:..:.: :..: 
XP_011 MCPQLAGAGSMGSPGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLA
               10        20        30        40        50        60

              60        70        80        90       100       110 
pF1KB4 KKGYQDVDTSLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTP
       :::::. :   : ..:::.:::. :. ..::.:.:::::.: : :::::::.:::..:::
XP_011 KKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQGENVFFLVTNFLVTP
               70        80        90       100       110       120

             120       130       140       150       160       170 
pF1KB4 NQRQNVCAENEGIPDGACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPL
        : :. : :. ..: . :  : ::  ::. : ..:::::.:.  ..  : ::::..:::.
XP_011 AQVQGRCPEHPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHR-TCEIWSWCPV
              130       140       150       160        170         

             180       190       200       210       220        230
pF1KB4 ETSSRPEEPFLKEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPK-NHYCP
       :..  : .:.: .:..::.:::: . : ::::::::.... : ...: :.. :. . :::
XP_011 ESGVVPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCP
     180       190       200       210       220       230         

              240       250       260       270       280       290
pF1KB4 IFRLGSVIRWAGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVS
       .::.:...  ::. :.:.:: :: .:: ..:.:::: . : : ::::: .:..:      
XP_011 VFRIGDLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSF-QLQEK------
     240       250       260       270       280        290        

              300       310       320       330       340       350
pF1KB4 SGYNFRFARYYRDAAGVEFRTLMKAYGIRFDVMVNGKGAFFCDLVLIYLIKKREFYRDKK
        .:::: : .. .  ::: :::.: ::::::..:.:.                       
XP_011 -SYNFRTATHWWEQPGVEARTLLKLYGIRFDILVTGQVGTGREVRAHPHGRHTGHRGSLA
             300       310       320       330       340       350 

              360       370       380       390       400       410
pF1KB4 YEEVRGLEDSSQEAEDEASGLGLSEQLTSGPGLLGMPEQQELQEPPEAKRGSSSQKGNGS
                                                                   
XP_011 GRGECEHCGHLQAAVSAADQGVSNACWSLRCLHIESRGAGWGGGRRAGSGAGTWVGPASP
             360       370       380       390       400       410 

>>NP_001243725 (OMIM: 600846) P2X purinoceptor 4 isoform  (404 aa)
 initn: 1095 init1: 407 opt: 1086  Z-score: 1282.6  bits: 246.3 E(85289): 1.1e-64
Smith-Waterman score: 1205; 48.3% identity (71.1% similar) in 408 aa overlap (4-367:2-404)

                10        20        30        40                   
pF1KB4 MGQAGC-KGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLV--------------
          :::  .:   ::.: : . :. ...::::. : .:  ::::..              
NP_001   MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGCYHPHLAEVEMES
                 10        20        30        40        50        

            50        60        70        80        90       100   
pF1KB4 --VWVFLIKKGYQDVDTSLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFV
          :::. .::::..: :. :.: ::::::: :::: :: ::::::::::::: :: .::
NP_001 PRRWVFVWEKGYQETD-SVVSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFV
       60        70         80        90       100       110       

           110       120         130       140       150       160 
pF1KB4 VTNLIVTPNQRQNVCAENEGIPDGA--CSKDSDCHAGEAVTAGNGVKTGRCLRRENLARG
       .::.:.: :: :..: :   :::..  :..:..: :: : : .:::.::::.  .. .. 
NP_001 MTNVILTMNQTQGLCPE---IPDATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVK-
       120       130          140       150       160       170    

             170        180       190       200       210       220
pF1KB4 TCEIFAWCPLETSSR-PEEPFLKEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSC
       :::. ::::.: ... :.  ::: ::.::...::.: .::::::: :..     ..::::
NP_001 TCEVAAWCPVEDDTHVPQPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSC
           180       190       200       210       220       230   

               230       240       250       260       270         
pF1KB4 HFGPK-NHYCPIFRLGSVIRWAGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFS
        .  : . .:::::::.... :: .:::.:.:::..::...:.:.::.::: : :.::: 
NP_001 IYDAKTDPFCPIFRLGKIVENAGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFR
           240       250       260       270       280       290   

     280        290       300       310       320        330       
pF1KB4 RLDNK-LSKSVSSGYNFRFARYYRDAAGVEFRTLMKAYGIRFDVMVNGK-GAF-------
       :::.. . ..:: :::::::.:::: :: : :::.::::::::..: :: : :       
NP_001 RLDTRDVEHNVSPGYNFRFAKYYRDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMI
           300       310       320       330       340       350   

                            340       350       360       370      
pF1KB4 --------------FCDLVLIYLIKKREFYRDKKYEEVRGLEDSSQEAEDEASGLGLSEQ
                     .::....: .::: .::.:::. :.  :..     :.         
NP_001 NIGSGLALLGMATVLCDIIVLYCMKKRLYYREKKYKYVEDYEQGLASELDQ         
           360       370       380       390       400             

        380       390       400       410       420  
pF1KB4 LTSGPGLLGMPEQQELQEPPEAKRGSSSQKGNGSVCPQLLEPHRST




422 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 20:33:31 2016 done: Fri Nov  4 20:33:32 2016
 Total Scan time:  9.050 Total Display time:  0.070

Function used was FASTA [36.3.4 Apr, 2011]
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