FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1508, 1126 aa 1>>>pF1KA1508 1126 - 1126 aa - 1126 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.1351+/-0.000452; mu= -5.0400+/- 0.028 mean_var=376.0856+/-75.872, 0's: 0 Z-trim(121.3): 369 B-trim: 0 in 0/57 Lambda= 0.066135 statistics sampled from 37346 (37759) to 37346 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.75), E-opt: 0.2 (0.443), width: 16 Scan time: 13.710 The best scores are: opt bits E(85289) XP_006722054 (OMIM: 610590) PREDICTED: rho GTPase- (1473) 7636 744.0 1.6e-213 XP_011523378 (OMIM: 610590) PREDICTED: rho GTPase- (1159) 7623 742.6 3.1e-213 NP_001186346 (OMIM: 610590) rho GTPase-activating (1491) 7623 742.7 3.7e-213 XP_011523375 (OMIM: 610590) PREDICTED: rho GTPase- (1476) 7616 742.1 5.9e-213 XP_016880391 (OMIM: 610590) PREDICTED: rho GTPase- (1119) 7404 721.7 5.9e-207 XP_006722056 (OMIM: 610590) PREDICTED: rho GTPase- (1249) 7405 721.9 6e-207 XP_011523379 (OMIM: 610590) PREDICTED: rho GTPase- (1117) 7400 721.3 7.6e-207 XP_011523376 (OMIM: 610590) PREDICTED: rho GTPase- (1397) 7069 689.9 2.9e-197 XP_011523377 (OMIM: 610590) PREDICTED: rho GTPase- (1285) 6332 619.5 4e-176 XP_006722055 (OMIM: 610590) PREDICTED: rho GTPase- (1408) 4735 467.2 3.2e-130 XP_016871950 (OMIM: 609870) PREDICTED: rho GTPase- (1948) 1339 143.3 1.4e-32 XP_016871949 (OMIM: 609870) PREDICTED: rho GTPase- (1948) 1339 143.3 1.4e-32 XP_005252601 (OMIM: 609870) PREDICTED: rho GTPase- (1948) 1339 143.3 1.4e-32 XP_005252599 (OMIM: 609870) PREDICTED: rho GTPase- (1958) 1339 143.3 1.4e-32 NP_065875 (OMIM: 609870) rho GTPase-activating pro (1958) 1339 143.3 1.4e-32 XP_016871948 (OMIM: 609870) PREDICTED: rho GTPase- (1958) 1339 143.3 1.4e-32 XP_011517908 (OMIM: 609870) PREDICTED: rho GTPase- (1924) 1303 139.8 1.5e-31 XP_011517907 (OMIM: 609870) PREDICTED: rho GTPase- (1982) 1303 139.8 1.5e-31 XP_011517906 (OMIM: 609870) PREDICTED: rho GTPase- (1992) 1303 139.8 1.5e-31 XP_011517904 (OMIM: 609870) PREDICTED: rho GTPase- (1992) 1303 139.8 1.5e-31 XP_011517905 (OMIM: 609870) PREDICTED: rho GTPase- (1992) 1303 139.8 1.5e-31 XP_011517909 (OMIM: 609870) PREDICTED: rho GTPase- (1491) 1224 132.2 2.3e-29 XP_011509785 (OMIM: 610578) PREDICTED: rho GTPase- ( 397) 539 66.3 4.1e-10 XP_016859989 (OMIM: 610578) PREDICTED: rho GTPase- ( 432) 539 66.4 4.4e-10 NP_060930 (OMIM: 610578) rho GTPase-activating pro ( 475) 539 66.4 4.7e-10 XP_016859988 (OMIM: 610578) PREDICTED: rho GTPase- ( 475) 539 66.4 4.7e-10 XP_011509781 (OMIM: 610578) PREDICTED: rho GTPase- ( 475) 539 66.4 4.7e-10 NP_954976 (OMIM: 610591) rho GTPase-activating pro ( 548) 472 60.1 4.4e-08 XP_011522776 (OMIM: 610591) PREDICTED: rho GTPase- ( 581) 472 60.1 4.6e-08 XP_005257185 (OMIM: 610591) PREDICTED: rho GTPase- ( 667) 472 60.1 5.1e-08 XP_016879801 (OMIM: 610591) PREDICTED: rho GTPase- ( 689) 472 60.1 5.2e-08 XP_011522774 (OMIM: 610591) PREDICTED: rho GTPase- ( 722) 472 60.2 5.4e-08 XP_011522773 (OMIM: 610591) PREDICTED: rho GTPase- ( 865) 472 60.2 6.1e-08 XP_006721810 (OMIM: 610591) PREDICTED: rho GTPase- ( 867) 472 60.2 6.1e-08 NP_001269219 (OMIM: 610591) rho GTPase-activating ( 889) 472 60.2 6.3e-08 XP_006721808 (OMIM: 610591) PREDICTED: rho GTPase- ( 889) 472 60.2 6.3e-08 XP_011522771 (OMIM: 610591) PREDICTED: rho GTPase- ( 900) 472 60.2 6.3e-08 XP_011522770 (OMIM: 610591) PREDICTED: rho GTPase- ( 922) 472 60.3 6.4e-08 XP_016879800 (OMIM: 610591) PREDICTED: rho GTPase- ( 922) 472 60.3 6.4e-08 XP_016872443 (OMIM: 610577) PREDICTED: rho GTPase- ( 742) 456 58.6 1.6e-07 NP_001257627 (OMIM: 610577) rho GTPase-activating ( 769) 456 58.7 1.6e-07 XP_011518063 (OMIM: 610577) PREDICTED: rho GTPase- ( 772) 456 58.7 1.6e-07 NP_001257628 (OMIM: 610577) rho GTPase-activating ( 794) 456 58.7 1.7e-07 XP_005252701 (OMIM: 610577) PREDICTED: rho GTPase- ( 794) 456 58.7 1.7e-07 NP_001257626 (OMIM: 610577) rho GTPase-activating ( 799) 456 58.7 1.7e-07 NP_001257625 (OMIM: 610577) rho GTPase-activating ( 816) 456 58.7 1.7e-07 NP_001257624 (OMIM: 610577) rho GTPase-activating ( 841) 456 58.7 1.7e-07 NP_060757 (OMIM: 610577) rho GTPase-activating pro ( 846) 456 58.7 1.7e-07 NP_001280010 (OMIM: 602857) beta-chimaerin isoform ( 261) 437 56.4 2.6e-07 NP_001193531 (OMIM: 118423,604356) N-chimaerin iso ( 334) 439 56.7 2.7e-07 >>XP_006722054 (OMIM: 610590) PREDICTED: rho GTPase-acti (1473 aa) initn: 7636 init1: 7636 opt: 7636 Z-score: 3954.6 bits: 744.0 E(85289): 1.6e-213 Smith-Waterman score: 7636; 100.0% identity (100.0% similar) in 1120 aa overlap (1-1120:1-1120) 10 20 30 40 50 60 pF1KA1 MEQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRHFIVYPPESAVHCSLKEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MEQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRHFIVYPPESAVHCSLKEEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 NGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 LIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEARSIPEPPPICYPRKTYAPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEARSIPEPPPICYPRKTYAPP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 ARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPSPGAFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPSPGAFP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 HLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRARSASQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRARSASQD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 RLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATRSAEALGPGALVSPRFERC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATRSAEALGPGALVSPRFERC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 GWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLLHALSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLLHALSF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 RDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEPPAEDRGDEVVLRQKPPTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEPPAEDRGDEVVLRQKPPTG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 RKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTEDSLASIPFIDEPTSPSID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTEDSLASIPFIDEPTSPSID 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 LQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQDCSSIKAGRRSSYLLAITT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQDCSSIKAGRRSSYLLAITT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 ERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSLDSWGTSEDADAPSKRHST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSLDSWGTSEDADAPSKRHST 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 SDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYAALRARSLSLSKERREPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYAALRARSLSLSKERREPGP 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 AAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLG 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 WIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFL 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 KQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAPRAFGVRLEECQPATENQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAPRAFGVRLEECQPATENQR 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA1 VPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVIS 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA1 SLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGH 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA1 LKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFS 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 pF1KA1 DEEDKGERTPVGDKEPQAVPNIEYLLPNIGRTVPPGDPGSADLLEI :::::::::::::::::::::::::::::::::::::::: XP_006 DEEDKGERTPVGDKEPQAVPNIEYLLPNIGRTVPPGDPGSDSTTCSSAKSKGSWAPKKEP 1090 1100 1110 1120 1130 1140 XP_006 YAREMLAISFISAVNRKRKKRREARGLGSSTDDDSEQEAHKPGAGATAPGTQERPQGPLP 1150 1160 1170 1180 1190 1200 >>XP_011523378 (OMIM: 610590) PREDICTED: rho GTPase-acti (1159 aa) initn: 7623 init1: 7623 opt: 7623 Z-score: 3949.3 bits: 742.6 E(85289): 3.1e-213 Smith-Waterman score: 7623; 100.0% identity (100.0% similar) in 1118 aa overlap (3-1120:21-1138) 10 20 30 40 pF1KA1 MEQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRH :::::::::::::::::::::::::::::::::::::::: XP_011 MNGVAFCLVGIPPRPEPRPPQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRH 10 20 30 40 50 60 50 60 70 80 90 100 pF1KA1 FIVYPPESAVHCSLKEEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FIVYPPESAVHCSLKEEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRL 70 80 90 100 110 120 110 120 130 140 150 160 pF1KA1 VKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEAR 130 140 150 160 170 180 170 180 190 200 210 220 pF1KA1 SIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHL 190 200 210 220 230 240 230 240 250 260 270 280 pF1KA1 DNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRA 250 260 270 280 290 300 290 300 310 320 330 340 pF1KA1 GERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATR 310 320 330 340 350 360 350 360 370 380 390 400 pF1KA1 SAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYR 370 380 390 400 410 420 410 420 430 440 450 460 pF1KA1 SYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEP 430 440 450 460 470 480 470 480 490 500 510 520 pF1KA1 PAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTE 490 500 510 520 530 540 530 540 550 560 570 580 pF1KA1 DSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQD 550 560 570 580 590 600 590 600 610 620 630 640 pF1KA1 CSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSL 610 620 630 640 650 660 650 660 670 680 690 700 pF1KA1 DSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYA 670 680 690 700 710 720 710 720 730 740 750 760 pF1KA1 ALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTT 730 740 750 760 770 780 770 780 790 800 810 820 pF1KA1 ADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKA 790 800 810 820 830 840 830 840 850 860 870 880 pF1KA1 DSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAP 850 860 870 880 890 900 890 900 910 920 930 940 pF1KA1 RAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRG 910 920 930 940 950 960 950 960 970 980 990 1000 pF1KA1 PGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKL 970 980 990 1000 1010 1020 1010 1020 1030 1040 1050 1060 pF1KA1 IRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMP 1030 1040 1050 1060 1070 1080 1070 1080 1090 1100 1110 1120 pF1KA1 DRYKIVETLIQHSDWFFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIGRTVPPGDPGSAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DRYKIVETLIQHSDWFFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIGRTVPPGDPGSDS 1090 1100 1110 1120 1130 1140 pF1KA1 LLEI XP_011 TTCSSAKSKLKKQRPEELL 1150 >>NP_001186346 (OMIM: 610590) rho GTPase-activating prot (1491 aa) initn: 7623 init1: 7623 opt: 7623 Z-score: 3947.8 bits: 742.7 E(85289): 3.7e-213 Smith-Waterman score: 7623; 100.0% identity (100.0% similar) in 1118 aa overlap (3-1120:21-1138) 10 20 30 40 pF1KA1 MEQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRH :::::::::::::::::::::::::::::::::::::::: NP_001 MNGVAFCLVGIPPRPEPRPPQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRH 10 20 30 40 50 60 50 60 70 80 90 100 pF1KA1 FIVYPPESAVHCSLKEEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FIVYPPESAVHCSLKEEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRL 70 80 90 100 110 120 110 120 130 140 150 160 pF1KA1 VKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEAR 130 140 150 160 170 180 170 180 190 200 210 220 pF1KA1 SIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHL 190 200 210 220 230 240 230 240 250 260 270 280 pF1KA1 DNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRA 250 260 270 280 290 300 290 300 310 320 330 340 pF1KA1 GERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATR 310 320 330 340 350 360 350 360 370 380 390 400 pF1KA1 SAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYR 370 380 390 400 410 420 410 420 430 440 450 460 pF1KA1 SYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEP 430 440 450 460 470 480 470 480 490 500 510 520 pF1KA1 PAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTE 490 500 510 520 530 540 530 540 550 560 570 580 pF1KA1 DSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQD 550 560 570 580 590 600 590 600 610 620 630 640 pF1KA1 CSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSL 610 620 630 640 650 660 650 660 670 680 690 700 pF1KA1 DSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYA 670 680 690 700 710 720 710 720 730 740 750 760 pF1KA1 ALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTT 730 740 750 760 770 780 770 780 790 800 810 820 pF1KA1 ADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKA 790 800 810 820 830 840 830 840 850 860 870 880 pF1KA1 DSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAP 850 860 870 880 890 900 890 900 910 920 930 940 pF1KA1 RAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRG 910 920 930 940 950 960 950 960 970 980 990 1000 pF1KA1 PGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKL 970 980 990 1000 1010 1020 1010 1020 1030 1040 1050 1060 pF1KA1 IRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMP 1030 1040 1050 1060 1070 1080 1070 1080 1090 1100 1110 1120 pF1KA1 DRYKIVETLIQHSDWFFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIGRTVPPGDPGSAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRYKIVETLIQHSDWFFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIGRTVPPGDPGSDS 1090 1100 1110 1120 1130 1140 pF1KA1 LLEI NP_001 TTCSSAKSKGSWAPKKEPYAREMLAISFISAVNRKRKKRREARGLGSSTDDDSEQEAHKP 1150 1160 1170 1180 1190 1200 >>XP_011523375 (OMIM: 610590) PREDICTED: rho GTPase-acti (1476 aa) initn: 7616 init1: 7616 opt: 7616 Z-score: 3944.3 bits: 742.1 E(85289): 5.9e-213 Smith-Waterman score: 7616; 100.0% identity (100.0% similar) in 1117 aa overlap (4-1120:7-1123) 10 20 30 40 50 pF1KA1 MEQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRHFIVYPPESAVHCSLK :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPLERGLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRHFIVYPPESAVHCSLK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KA1 EEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KA1 VIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEARSIPEPPPICYPRKTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEARSIPEPPPICYPRKTY 130 140 150 160 170 180 180 190 200 210 220 230 pF1KA1 APPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPSPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 APPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPSPG 190 200 210 220 230 240 240 250 260 270 280 290 pF1KA1 AFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRARSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRARSA 250 260 270 280 290 300 300 310 320 330 340 350 pF1KA1 SQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATRSAEALGPGALVSPRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATRSAEALGPGALVSPRF 310 320 330 340 350 360 360 370 380 390 400 410 pF1KA1 ERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLLHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLLHA 370 380 390 400 410 420 420 430 440 450 460 470 pF1KA1 LSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEPPAEDRGDEVVLRQKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEPPAEDRGDEVVLRQKP 430 440 450 460 470 480 480 490 500 510 520 530 pF1KA1 PTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTEDSLASIPFIDEPTSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTEDSLASIPFIDEPTSP 490 500 510 520 530 540 540 550 560 570 580 590 pF1KA1 SIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQDCSSIKAGRRSSYLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQDCSSIKAGRRSSYLLA 550 560 570 580 590 600 600 610 620 630 640 650 pF1KA1 ITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSLDSWGTSEDADAPSKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSLDSWGTSEDADAPSKR 610 620 630 640 650 660 660 670 680 690 700 710 pF1KA1 HSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYAALRARSLSLSKERRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYAALRARSLSLSKERRE 670 680 690 700 710 720 720 730 740 750 760 770 pF1KA1 PGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDD 730 740 750 760 770 780 780 790 800 810 820 830 pF1KA1 MLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKS 790 800 810 820 830 840 840 850 860 870 880 890 pF1KA1 EFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAPRAFGVRLEECQPATE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAPRAFGVRLEECQPATE 850 860 870 880 890 900 900 910 920 930 940 950 pF1KA1 NQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLN 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KA1 VISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFL 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KA1 VGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDW 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 pF1KA1 FFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIGRTVPPGDPGSADLLEI ::::::::::::::::::::::::::::::::::::::::::: XP_011 FFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIGRTVPPGDPGSDSTTCSSAKSKGSWAPK 1090 1100 1110 1120 1130 1140 XP_011 KEPYAREMLAISFISAVNRKRKKRREARGLGSSTDDDSEQEAHKPGAGATAPGTQERPQG 1150 1160 1170 1180 1190 1200 >>XP_016880391 (OMIM: 610590) PREDICTED: rho GTPase-acti (1119 aa) initn: 7396 init1: 7396 opt: 7404 Z-score: 3836.5 bits: 721.7 E(85289): 5.9e-207 Smith-Waterman score: 7404; 99.2% identity (99.4% similar) in 1099 aa overlap (3-1099:21-1119) 10 20 30 40 pF1KA1 MEQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRH :::::::::::::::::::::::::::::::::::::::: XP_016 MNGVAFCLVGIPPRPEPRPPQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRH 10 20 30 40 50 60 50 60 70 80 90 100 pF1KA1 FIVYPPESAVHCSLKEEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FIVYPPESAVHCSLKEEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRL 70 80 90 100 110 120 110 120 130 140 150 160 pF1KA1 VKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEAR 130 140 150 160 170 180 170 180 190 200 210 220 pF1KA1 SIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHL 190 200 210 220 230 240 230 240 250 260 270 280 pF1KA1 DNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRA 250 260 270 280 290 300 290 300 310 320 330 340 pF1KA1 GERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATR 310 320 330 340 350 360 350 360 370 380 390 400 pF1KA1 SAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYR 370 380 390 400 410 420 410 420 430 440 450 460 pF1KA1 SYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEP 430 440 450 460 470 480 470 480 490 500 510 520 pF1KA1 PAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTE 490 500 510 520 530 540 530 540 550 560 570 580 pF1KA1 DSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQD 550 560 570 580 590 600 590 600 610 620 630 640 pF1KA1 CSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSL 610 620 630 640 650 660 650 660 670 680 690 700 pF1KA1 DSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYA 670 680 690 700 710 720 710 720 730 740 750 760 pF1KA1 ALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTT 730 740 750 760 770 780 770 780 790 800 810 820 pF1KA1 ADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKA 790 800 810 820 830 840 830 840 850 860 870 880 pF1KA1 DSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAP 850 860 870 880 890 900 890 900 910 920 930 940 pF1KA1 RAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRG 910 920 930 940 950 960 950 960 970 980 990 1000 pF1KA1 PGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKL 970 980 990 1000 1010 1020 1010 1020 1030 1040 1050 1060 pF1KA1 IRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMP 1030 1040 1050 1060 1070 1080 1070 1080 1090 1100 1110 1120 pF1KA1 DRYKIVETLIQHSDWFFSDEEDKGERT--PVGDKEPQAVPNIEYLLPNIGRTVPPGDPGS :::::::::::::::::::::::::: :: . :. : XP_016 DRYKIVETLIQHSDWFFSDEEDKGERILPPVVQPSPRYV 1090 1100 1110 pF1KA1 ADLLEI >>XP_006722056 (OMIM: 610590) PREDICTED: rho GTPase-acti (1249 aa) initn: 7396 init1: 7396 opt: 7405 Z-score: 3836.4 bits: 721.9 E(85289): 6e-207 Smith-Waterman score: 7405; 97.5% identity (98.2% similar) in 1122 aa overlap (3-1121:21-1142) 10 20 30 40 pF1KA1 MEQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRH :::::::::::::::::::::::::::::::::::::::: XP_006 MNGVAFCLVGIPPRPEPRPPQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRH 10 20 30 40 50 60 50 60 70 80 90 100 pF1KA1 FIVYPPESAVHCSLKEEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FIVYPPESAVHCSLKEEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRL 70 80 90 100 110 120 110 120 130 140 150 160 pF1KA1 VKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEAR 130 140 150 160 170 180 170 180 190 200 210 220 pF1KA1 SIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHL 190 200 210 220 230 240 230 240 250 260 270 280 pF1KA1 DNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRA 250 260 270 280 290 300 290 300 310 320 330 340 pF1KA1 GERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATR 310 320 330 340 350 360 350 360 370 380 390 400 pF1KA1 SAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYR 370 380 390 400 410 420 410 420 430 440 450 460 pF1KA1 SYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEP 430 440 450 460 470 480 470 480 490 500 510 520 pF1KA1 PAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTE 490 500 510 520 530 540 530 540 550 560 570 580 pF1KA1 DSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQD 550 560 570 580 590 600 590 600 610 620 630 640 pF1KA1 CSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSL 610 620 630 640 650 660 650 660 670 680 690 700 pF1KA1 DSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYA 670 680 690 700 710 720 710 720 730 740 750 760 pF1KA1 ALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTT 730 740 750 760 770 780 770 780 790 800 810 820 pF1KA1 ADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKA 790 800 810 820 830 840 830 840 850 860 870 880 pF1KA1 DSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAP 850 860 870 880 890 900 890 900 910 920 930 940 pF1KA1 RAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRG 910 920 930 940 950 960 950 960 970 980 990 1000 pF1KA1 PGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKL 970 980 990 1000 1010 1020 1010 1020 1030 1040 1050 1060 pF1KA1 IRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMP 1030 1040 1050 1060 1070 1080 1070 1080 1090 1100 1110 pF1KA1 DRYKIVETLIQHSDWFFSDEEDKGERT--PVGDKEPQAV-PNIEYLLPNIGRTVPPGDPG :::::::::::::::::::::::::: :: . :.. : . :. : . :. XP_006 DRYKIVETLIQHSDWFFSDEEDKGERILPPVVQPSPRVRGPPRRSRTPGRCWRSPSSRPS 1090 1100 1110 1120 1130 1140 1120 pF1KA1 SADLLEI .: XP_006 TASARSGGRRGGWAAAPTTTRSRRRTSLGRGPQRRGLRSGRRGRCLAPSPPRPPDASVPR 1150 1160 1170 1180 1190 1200 >>XP_011523379 (OMIM: 610590) PREDICTED: rho GTPase-acti (1117 aa) initn: 7396 init1: 7396 opt: 7400 Z-score: 3834.5 bits: 721.3 E(85289): 7.6e-207 Smith-Waterman score: 7400; 99.4% identity (99.5% similar) in 1096 aa overlap (3-1096:21-1116) 10 20 30 40 pF1KA1 MEQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRH :::::::::::::::::::::::::::::::::::::::: XP_011 MNGVAFCLVGIPPRPEPRPPQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRH 10 20 30 40 50 60 50 60 70 80 90 100 pF1KA1 FIVYPPESAVHCSLKEEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FIVYPPESAVHCSLKEEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRL 70 80 90 100 110 120 110 120 130 140 150 160 pF1KA1 VKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEAR 130 140 150 160 170 180 170 180 190 200 210 220 pF1KA1 SIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHL 190 200 210 220 230 240 230 240 250 260 270 280 pF1KA1 DNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRA 250 260 270 280 290 300 290 300 310 320 330 340 pF1KA1 GERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATR 310 320 330 340 350 360 350 360 370 380 390 400 pF1KA1 SAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYR 370 380 390 400 410 420 410 420 430 440 450 460 pF1KA1 SYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEP 430 440 450 460 470 480 470 480 490 500 510 520 pF1KA1 PAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTE 490 500 510 520 530 540 530 540 550 560 570 580 pF1KA1 DSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQD 550 560 570 580 590 600 590 600 610 620 630 640 pF1KA1 CSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSL 610 620 630 640 650 660 650 660 670 680 690 700 pF1KA1 DSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYA 670 680 690 700 710 720 710 720 730 740 750 760 pF1KA1 ALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTT 730 740 750 760 770 780 770 780 790 800 810 820 pF1KA1 ADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKA 790 800 810 820 830 840 830 840 850 860 870 880 pF1KA1 DSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAP 850 860 870 880 890 900 890 900 910 920 930 940 pF1KA1 RAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRG 910 920 930 940 950 960 950 960 970 980 990 1000 pF1KA1 PGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKL 970 980 990 1000 1010 1020 1010 1020 1030 1040 1050 1060 pF1KA1 IRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMP 1030 1040 1050 1060 1070 1080 1070 1080 1090 1100 1110 1120 pF1KA1 DRYKIVETLIQHSDWFFSDEEDKGERT--PVGDKEPQAVPNIEYLLPNIGRTVPPGDPGS :::::::::::::::::::::::::: :: . : XP_011 DRYKIVETLIQHSDWFFSDEEDKGERILPPVVQPSPS 1090 1100 1110 pF1KA1 ADLLEI >>XP_011523376 (OMIM: 610590) PREDICTED: rho GTPase-acti (1397 aa) initn: 7069 init1: 7069 opt: 7069 Z-score: 3662.5 bits: 689.9 E(85289): 2.9e-197 Smith-Waterman score: 7069; 100.0% identity (100.0% similar) in 1044 aa overlap (77-1120:1-1044) 50 60 70 80 90 100 pF1KA1 PPESAVHCSLKEEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRLVKVN :::::::::::::::::::::::::::::: XP_011 MDTIFVKNVKEDGPAHRAGLRTGDRLVKVN 10 20 30 110 120 130 140 150 160 pF1KA1 GESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEARSIPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEARSIPE 40 50 60 70 80 90 170 180 190 200 210 220 pF1KA1 PPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHLDNSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHLDNSS 100 110 120 130 140 150 230 240 250 260 270 280 pF1KA1 LGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRAGERR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRAGERR 160 170 180 190 200 210 290 300 310 320 330 340 pF1KA1 CPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATRSAEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATRSAEA 220 230 240 250 260 270 350 360 370 380 390 400 pF1KA1 LGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSP 280 290 300 310 320 330 410 420 430 440 450 460 pF1KA1 SFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEPPAED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEPPAED 340 350 360 370 380 390 470 480 490 500 510 520 pF1KA1 RGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTEDSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTEDSLA 400 410 420 430 440 450 530 540 550 560 570 580 pF1KA1 SIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQDCSSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQDCSSI 460 470 480 490 500 510 590 600 610 620 630 640 pF1KA1 KAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSLDSWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSLDSWG 520 530 540 550 560 570 650 660 670 680 690 700 pF1KA1 TSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYAALRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYAALRA 580 590 600 610 620 630 710 720 730 740 750 760 pF1KA1 RSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFC 640 650 660 670 680 690 770 780 790 800 810 820 pF1KA1 EYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKADSSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKADSSP 700 710 720 730 740 750 830 840 850 860 870 880 pF1KA1 KGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAPRAFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAPRAFG 760 770 780 790 800 810 890 900 910 920 930 940 pF1KA1 VRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDI 820 830 840 850 860 870 950 960 970 980 990 1000 pF1KA1 NLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDL 880 890 900 910 920 930 1010 1020 1030 1040 1050 1060 pF1KA1 PGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYK 940 950 960 970 980 990 1070 1080 1090 1100 1110 1120 pF1KA1 IVETLIQHSDWFFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIGRTVPPGDPGSADLLEI :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IVETLIQHSDWFFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIGRTVPPGDPGSDSTTCS 1000 1010 1020 1030 1040 1050 XP_011 SAKSKGSWAPKKEPYAREMLAISFISAVNRKRKKRREARGLGSSTDDDSEQEAHKPGAGA 1060 1070 1080 1090 1100 1110 >>XP_011523377 (OMIM: 610590) PREDICTED: rho GTPase-acti (1285 aa) initn: 6332 init1: 6332 opt: 6332 Z-score: 3283.0 bits: 619.5 E(85289): 4e-176 Smith-Waterman score: 6332; 100.0% identity (100.0% similar) in 932 aa overlap (189-1120:1-932) 160 170 180 190 200 210 pF1KA1 GEARSIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAA :::::::::::::::::::::::::::::: XP_011 MVPEPTSALPSDPRSPAAWSDPGLRVPPAA 10 20 30 220 230 240 250 260 270 pF1KA1 RAHLDNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RAHLDNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQV 40 50 60 70 80 90 280 290 300 310 320 330 pF1KA1 PRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLS 100 110 120 130 140 150 340 350 360 370 380 390 pF1KA1 RATRSAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RATRSAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGY 160 170 180 190 200 210 400 410 420 430 440 450 pF1KA1 IGYRSYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IGYRSYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTR 220 230 240 250 260 270 460 470 480 490 500 510 pF1KA1 ALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPL 280 290 300 310 320 330 520 530 540 550 560 570 pF1KA1 ATTEDSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ATTEDSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRH 340 350 360 370 380 390 580 590 600 610 620 630 pF1KA1 YSQDCSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YSQDCSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFT 400 410 420 430 440 450 640 650 660 670 680 690 pF1KA1 DGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWK 460 470 480 490 500 510 700 710 720 730 740 750 pF1KA1 RVYAALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RVYAALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVF 520 530 540 550 560 570 760 770 780 790 800 810 pF1KA1 RLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSS 580 590 600 610 620 630 820 830 840 850 860 870 pF1KA1 GPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNK 640 650 660 670 680 690 880 890 900 910 920 930 pF1KA1 KAAPRAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KAAPRAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQ 700 710 720 730 740 750 940 950 960 970 980 990 pF1KA1 LNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRT 760 770 780 790 800 810 1000 1010 1020 1030 1040 1050 pF1KA1 LRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMV 820 830 840 850 860 870 1060 1070 1080 1090 1100 1110 pF1KA1 THMPDRYKIVETLIQHSDWFFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIGRTVPPGDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 THMPDRYKIVETLIQHSDWFFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIGRTVPPGDP 880 890 900 910 920 930 1120 pF1KA1 GSADLLEI :: XP_011 GSDSTTCSSAKSKGSWAPKKEPYAREMLAISFISAVNRKRKKRREARGLGSSTDDDSEQE 940 950 960 970 980 990 >>XP_006722055 (OMIM: 610590) PREDICTED: rho GTPase-acti (1408 aa) initn: 4727 init1: 4727 opt: 4735 Z-score: 2458.9 bits: 467.2 E(85289): 3.2e-130 Smith-Waterman score: 6898; 92.6% identity (92.6% similar) in 1118 aa overlap (3-1120:21-1055) 10 20 30 40 pF1KA1 MEQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRH :::::::::::::::::::::::::::::::::::::::: XP_006 MNGVAFCLVGIPPRPEPRPPQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRH 10 20 30 40 50 60 50 60 70 80 90 100 pF1KA1 FIVYPPESAVHCSLKEEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FIVYPPESAVHCSLKEEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRL 70 80 90 100 110 120 110 120 130 140 150 160 pF1KA1 VKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEAR 130 140 150 160 170 180 170 180 190 200 210 220 pF1KA1 SIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHL 190 200 210 220 230 240 230 240 250 260 270 280 pF1KA1 DNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRA 250 260 270 280 290 300 290 300 310 320 330 340 pF1KA1 GERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATR 310 320 330 340 350 360 350 360 370 380 390 400 pF1KA1 SAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYR 370 380 390 400 410 420 410 420 430 440 450 460 pF1KA1 SYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEP 430 440 450 460 470 480 470 480 490 500 510 520 pF1KA1 PAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTE 490 500 510 520 530 540 530 540 550 560 570 580 pF1KA1 DSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQD 550 560 570 580 590 600 590 600 610 620 630 640 pF1KA1 CSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSL 610 620 630 640 650 660 650 660 670 680 690 700 pF1KA1 DSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYA :::::::::::::::::::::::::::::::::::::::::::::: XP_006 DSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGK-------------- 670 680 690 700 710 720 730 740 750 760 pF1KA1 ALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTT XP_006 ------------------------------------------------------------ 770 780 790 800 810 820 pF1KA1 ADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKA ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ---------AEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKA 710 720 730 740 750 830 840 850 860 870 880 pF1KA1 DSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAP 760 770 780 790 800 810 890 900 910 920 930 940 pF1KA1 RAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRG 820 830 840 850 860 870 950 960 970 980 990 1000 pF1KA1 PGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKL 880 890 900 910 920 930 1010 1020 1030 1040 1050 1060 pF1KA1 IRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMP 940 950 960 970 980 990 1070 1080 1090 1100 1110 1120 pF1KA1 DRYKIVETLIQHSDWFFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIGRTVPPGDPGSAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DRYKIVETLIQHSDWFFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIGRTVPPGDPGSDS 1000 1010 1020 1030 1040 1050 pF1KA1 LLEI XP_006 TTCSSAKSKGSWAPKKEPYAREMLAISFISAVNRKRKKRREARGLGSSTDDDSEQEAHKP 1060 1070 1080 1090 1100 1110 1126 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 02:21:53 2016 done: Sat Nov 5 02:21:55 2016 Total Scan time: 13.710 Total Display time: 0.480 Function used was FASTA [36.3.4 Apr, 2011]