Result of FASTA (ccds) for pF1KE0668
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE0668, 393 aa
  1>>>pF1KE0668 393 - 393 aa - 393 aa
Library: human.CCDS.faa
  18511270 residues in 32554 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 7.7708+/-0.000947; mu= 5.9719+/- 0.056
 mean_var=234.2741+/-51.670, 0's: 0 Z-trim(112.4): 631  B-trim: 0 in 0/51
 Lambda= 0.083794
 statistics sampled from 12415 (13174) to 12415 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.757), E-opt: 0.2 (0.405), width:  16
 Scan time:  3.080

The best scores are:                                      opt bits E(32554)
CCDS10216.1 MAP2K1 gene_id:5604|Hs108|chr15        ( 393) 2625 330.4 1.8e-90
CCDS12120.1 MAP2K2 gene_id:5605|Hs108|chr19        ( 400) 2130 270.5 1.9e-72
CCDS55970.1 MAP2K5 gene_id:5607|Hs108|chr15        ( 412)  808 110.7 2.4e-24
CCDS10224.1 MAP2K5 gene_id:5607|Hs108|chr15        ( 448)  808 110.8 2.6e-24
CCDS42051.1 MAP2K5 gene_id:5607|Hs108|chr15        ( 438)  761 105.1 1.3e-22
CCDS11686.1 MAP2K6 gene_id:5608|Hs108|chr17        ( 334)  636 89.8 3.8e-18
CCDS11162.1 MAP2K4 gene_id:6416|Hs108|chr17        ( 399)  612 87.0 3.2e-17
CCDS62095.1 MAP2K4 gene_id:6416|Hs108|chr17        ( 410)  612 87.0 3.3e-17
CCDS11218.1 MAP2K3 gene_id:5606|Hs108|chr17        ( 318)  608 86.4 3.9e-17
CCDS11217.1 MAP2K3 gene_id:5606|Hs108|chr17        ( 347)  608 86.5 4.1e-17
CCDS82194.1 MAP2K6 gene_id:5608|Hs108|chr17        ( 278)  600 85.4   7e-17
CCDS42491.1 MAP2K7 gene_id:5609|Hs108|chr19        ( 419)  590 84.4 2.1e-16
CCDS74277.1 MAP2K7 gene_id:5609|Hs108|chr19        ( 435)  590 84.4 2.2e-16
CCDS74278.1 MAP2K7 gene_id:5609|Hs108|chr19        ( 426)  556 80.3 3.7e-15
CCDS13341.1 STK4 gene_id:6789|Hs108|chr20          ( 487)  510 74.8 1.9e-13
CCDS59108.1 STK3 gene_id:6788|Hs108|chr8           ( 519)  510 74.8   2e-13
CCDS47900.1 STK3 gene_id:6788|Hs108|chr8           ( 491)  509 74.7 2.1e-13
CCDS2549.1 STK25 gene_id:10494|Hs108|chr2          ( 426)  483 71.5 1.7e-12
CCDS32001.1 STK24 gene_id:8428|Hs108|chr13         ( 431)  478 70.9 2.6e-12
CCDS9488.1 STK24 gene_id:8428|Hs108|chr13          ( 443)  478 70.9 2.6e-12
CCDS14631.1 STK26 gene_id:51765|Hs108|chrX         ( 416)  469 69.8 5.3e-12
CCDS34290.1 STK10 gene_id:6793|Hs108|chr5          ( 968)  449 67.8 4.9e-11
CCDS42564.1 MAP4K1 gene_id:11184|Hs108|chr19       ( 821)  446 67.3 5.7e-11
CCDS59385.1 MAP4K1 gene_id:11184|Hs108|chr19       ( 833)  446 67.3 5.7e-11


>>CCDS10216.1 MAP2K1 gene_id:5604|Hs108|chr15             (393 aa)
 initn: 2625 init1: 2625 opt: 2625  Z-score: 1737.8  bits: 330.4 E(32554): 1.8e-90
Smith-Waterman score: 2625; 100.0% identity (100.0% similar) in 393 aa overlap (1-393:1-393)

               10        20        30        40        50        60
pF1KE0 MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE0 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE0 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
              310       320       330       340       350       360

              370       380       390   
pF1KE0 IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
       :::::::::::::::::::::::::::::::::
CCDS10 IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
              370       380       390   

>>CCDS12120.1 MAP2K2 gene_id:5605|Hs108|chr19             (400 aa)
 initn: 2120 init1: 1539 opt: 2130  Z-score: 1414.3  bits: 270.5 E(32554): 1.9e-72
Smith-Waterman score: 2130; 80.4% identity (92.0% similar) in 398 aa overlap (1-391:2-399)

                  10         20        30        40        50      
pF1KE0  MPKKKPT-P-IQLNPA-PDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQ
        . ..::. : . .::.  .: . .. ...:.::  ::::::::::::::.:::::::::
CCDS12 MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ
               10        20        30        40        50        60

         60        70        80        90       100       110      
pF1KE0 KQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQ
       : :::::::::::.:::::::::::: ::.:.::::.:::::::::::::::::::::::
CCDS12 KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
               70        80        90       100       110       120

        120       130       140       150       160       170      
pF1KE0 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG
       ::::::::::::::::::::::::::::::::::::::::.: ::::.:::::::::..:
CCDS12 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
              130       140       150       160       170       180

        180       190       200       210       220       230      
pF1KE0 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
       :.::::::.:::::::::::::::::::::::::::::::::::::::::::::.:::::
CCDS12 LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQ
              190       200       210       220       230       240

        240       250       260       270           280       290  
pF1KE0 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQV----EGDAAETPPRPRT
       :::::::::::::::::::.:::::::::::::::: .::  :    ::.     :::: 
CCDS12 GTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRP
              250       260       270       280       290       300

            300       310       320       330       340       350  
pF1KE0 PGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADL
       ::::.:..:::::: :::::::::::::::::::.:::. .::.::::::::::::::::
CCDS12 PGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADL
              310       320       330       340       350       360

            360       370       380       390   
pF1KE0 KQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
       :.:  :.:::::..::::::::::.:. ::::.:::..:  
CCDS12 KMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV 
              370       380       390       400 

>>CCDS55970.1 MAP2K5 gene_id:5607|Hs108|chr15             (412 aa)
 initn: 917 init1: 400 opt: 808  Z-score: 550.5  bits: 110.7 E(32554): 2.4e-24
Smith-Waterman score: 885; 42.6% identity (69.7% similar) in 333 aa overlap (48-379:110-402)

        20        30        40        50        60        70       
pF1KE0 SAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAG
                                     :.  : : .    :.....:..  . :: :
CCDS55 NIHGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHG
      80        90       100       110       120       130         

        80        90       100       110       120       130       
pF1KE0 NGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDG
       :::.:.:. : ::: ..: :.: :.:   ...::. ::..:..:.: ::.::::::. ..
CCDS55 NGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVEN
     140       150       160       170       180       190         

       140       150       160       170       180       190       
pF1KE0 EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNIL
       .:::: : ::::::: : .:   .::..::....::.::::::  . ::.::::::::.:
CCDS55 RISICTEFMDGGSLD-VYRK---MPEHVLGRIAVAVVKGLTYLW-SLKILHRDVKPSNML
     200       210           220       230        240       250    

       200       210       220       230       240       250       
pF1KE0 VNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMA
       ::.::..:::::::: ::..:.:...::: .::.:::..: .:...::.::.:.:..:.:
CCDS55 VNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELA
          260       270       280       290       300       310    

       260       270       280       290       300       310       
pF1KE0 VGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYI
       .::.: :  . ..  ::                     ::              .::. :
CCDS55 LGRFPYPQIQKNQGSLM---------------------PL--------------QLLQCI
          320       330                                            

       320       330       340       350       360        370      
pF1KE0 VNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI-KRSDAEEVDFAGWLC
       :.:  : :: : ::  :  :...:. :.: ::   ..:: : :: . .:.. .  . :.:
CCDS55 VDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVVSMWVC
     340       350       360       370       380       390         

        380       390   
pF1KE0 STIGLNQPSTPTHAAGV
        ..              
CCDS55 RALEERRSQQGPP    
     400       410      

>>CCDS10224.1 MAP2K5 gene_id:5607|Hs108|chr15             (448 aa)
 initn: 917 init1: 400 opt: 808  Z-score: 550.1  bits: 110.8 E(32554): 2.6e-24
Smith-Waterman score: 885; 42.6% identity (69.7% similar) in 333 aa overlap (48-379:146-438)

        20        30        40        50        60        70       
pF1KE0 SAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAG
                                     :.  : : .    :.....:..  . :: :
CCDS10 NIHGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHG
         120       130       140       150       160       170     

        80        90       100       110       120       130       
pF1KE0 NGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDG
       :::.:.:. : ::: ..: :.: :.:   ...::. ::..:..:.: ::.::::::. ..
CCDS10 NGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVEN
         180       190       200       210       220       230     

       140       150       160       170       180       190       
pF1KE0 EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNIL
       .:::: : ::::::: : .:   .::..::....::.::::::  . ::.::::::::.:
CCDS10 RISICTEFMDGGSLD-VYRK---MPEHVLGRIAVAVVKGLTYLW-SLKILHRDVKPSNML
         240       250           260       270        280       290

       200       210       220       230       240       250       
pF1KE0 VNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMA
       ::.::..:::::::: ::..:.:...::: .::.:::..: .:...::.::.:.:..:.:
CCDS10 VNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELA
              300       310       320       330       340       350

       260       270       280       290       300       310       
pF1KE0 VGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYI
       .::.: :  . ..  ::                     ::              .::. :
CCDS10 LGRFPYPQIQKNQGSLM---------------------PL--------------QLLQCI
              360                                          370     

       320       330       340       350       360        370      
pF1KE0 VNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI-KRSDAEEVDFAGWLC
       :.:  : :: : ::  :  :...:. :.: ::   ..:: : :: . .:.. .  . :.:
CCDS10 VDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVVSMWVC
         380       390       400       410       420       430     

        380       390   
pF1KE0 STIGLNQPSTPTHAAGV
        ..              
CCDS10 RALEERRSQQGPP    
         440            

>>CCDS42051.1 MAP2K5 gene_id:5607|Hs108|chr15             (438 aa)
 initn: 868 init1: 351 opt: 761  Z-score: 519.5  bits: 105.1 E(32554): 1.3e-22
Smith-Waterman score: 814; 41.1% identity (67.6% similar) in 333 aa overlap (48-379:146-428)

        20        30        40        50        60        70       
pF1KE0 SAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAG
                                     :.  : : .    :.....:..  . :: :
CCDS42 NIHGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHG
         120       130       140       150       160       170     

        80        90       100       110       120       130       
pF1KE0 NGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDG
       :::.:.:. : ::: ..: :.: :.:   ...::. ::..:..:.: ::.::::::. ..
CCDS42 NGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVEN
         180       190       200       210       220       230     

       140       150       160       170       180       190       
pF1KE0 EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNIL
       .:::: : ::::::: : .:   .::..::....::.::::::  . ::.::::::::.:
CCDS42 RISICTEFMDGGSLD-VYRK---MPEHVLGRIAVAVVKGLTYLW-SLKILHRDVKPSNML
         240       250           260       270        280       290

       200       210       220       230       240       250       
pF1KE0 VNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMA
       ::.::..:::::::: ::..:.:...::: .::.:::..: .:...::.::.:.:..:. 
CCDS42 VNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMEI-
              300       310       320       330       340          

       260       270       280       290       300       310       
pF1KE0 VGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYI
                . ..  ::                     ::              .::. :
CCDS42 ---------QKNQGSLM---------------------PL--------------QLLQCI
              350                                          360     

       320       330       340       350       360        370      
pF1KE0 VNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI-KRSDAEEVDFAGWLC
       :.:  : :: : ::  :  :...:. :.: ::   ..:: : :: . .:.. .  . :.:
CCDS42 VDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVVSMWVC
         370       380       390       400       410       420     

        380       390   
pF1KE0 STIGLNQPSTPTHAAGV
        ..              
CCDS42 RALEERRSQQGPP    
         430            

>>CCDS11686.1 MAP2K6 gene_id:5608|Hs108|chr17             (334 aa)
 initn: 767 init1: 286 opt: 636  Z-score: 439.2  bits: 89.8 E(32554): 3.8e-18
Smith-Waterman score: 727; 38.0% identity (63.2% similar) in 329 aa overlap (62-380:47-333)

              40        50        60        70        80        90 
pF1KE0 ALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSG
                                     :.: ::.: : ::: :  ::: :. : :::
CCDS11 KEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSG
         20        30        40        50        60        70      

             100       110        120       130       140       150
pF1KE0 LVMARKLIHLEIKPAIRNQIIRELQV-LHECNSPYIVGFYGAFYSDGEISICMEHMDGGS
        .:: : :.  ..   ..... .:.. ..  . :. : ::::.. .:.. :::: ::  :
CCDS11 QIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDT-S
         80        90       100       110       120       130      

                  160       170       180       190       200      
pF1KE0 LD----QVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKL
       ::    ::. :.  :::.::::......:.: .:. : ...::::::::.:.:. :..:.
CCDS11 LDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKM
         140       150       160       170       180       190     

        210       220        230           240       250       260 
pF1KE0 CDFGVSGQLIDSMANSF-VGTRSYMSPER----LQGTHYSVQSDIWSMGLSLVEMAVGRY
       ::::.:: :.::.:... .: . ::.:::    :.   :::.:::::.:....:.:. :.
CCDS11 CDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF
         200       210       220       230       240       250     

             270       280       290       300       310       320 
pF1KE0 PIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEP
       :                   :.  ::                       :. :  .:.::
CCDS11 PY------------------DSWGTP-----------------------FQQLKQVVEEP
                           260                              270    

             330       340       350       360       370       380 
pF1KE0 PPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL
        :.::.  :: :: ::...:: ::  ::    .:: : :.   ... .: :...   .: 
CCDS11 SPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD
          280       290       300       310       320       330    

             390   
pF1KE0 NQPSTPTHAAGV

>>CCDS11162.1 MAP2K4 gene_id:6416|Hs108|chr17             (399 aa)
 initn: 641 init1: 285 opt: 612  Z-score: 422.6  bits: 87.0 E(32554): 3.2e-17
Smith-Waterman score: 676; 36.2% identity (62.3% similar) in 337 aa overlap (66-388:100-393)

          40        50        60        70        80        90     
pF1KE0 KLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMA
                                     .:.. ..:.: :  : : :. ::::: .::
CCDS11 NPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMA
      70        80        90       100       110       120         

         100       110        120       130       140       150    
pF1KE0 RKLIHLEIKPAIRNQIIRELQV-LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQV
        : :.  .    ..:.. .:.: ..  . :::: ::::.. .:.  :::: :.  :.:. 
CCDS11 VKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMST-SFDKF
     130       140       150       160       170       180         

          160            170       180       190       200         
pF1KE0 LKKAGR-----IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDF
        : .       :::.::::...:..:.:..:.:. ::.:::.::::::..  :.::::::
CCDS11 YKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDF
      190       200       210       220       230       240        

     210       220        230           240       250       260    
pF1KE0 GVSGQLIDSMANSF-VGTRSYMSPERLQGTH----YSVQSDIWSMGLSLVEMAVGRYPIP
       :.::::.::.:..  .: : ::.:::.. .     :.:.::.::.:..: :.:.::.: :
CCDS11 GISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYP
      250       260       270       280       290       300        

          270       280       290       300       310       320    
pF1KE0 PPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPK
         ..                                         .:. :  .:.  ::.
CCDS11 KWNS-----------------------------------------VFDQLTQVVKGDPPQ
      310                                                320       

             330       340       350       360       370       380 
pF1KE0 LPSGV---FSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL
       : ..    ::  : .::: :: :. ..:   :.:. : ::   . . :. : ..:. .  
CCDS11 LSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILD-
       330       340       350       360       370       380       

             390    
pF1KE0 NQPSTPTHAAGV 
       ..:.::.      
CCDS11 QMPATPSSPMYVD
        390         

>>CCDS62095.1 MAP2K4 gene_id:6416|Hs108|chr17             (410 aa)
 initn: 664 init1: 285 opt: 612  Z-score: 422.5  bits: 87.0 E(32554): 3.3e-17
Smith-Waterman score: 676; 36.2% identity (62.3% similar) in 337 aa overlap (66-388:111-404)

          40        50        60        70        80        90     
pF1KE0 KLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMA
                                     .:.. ..:.: :  : : :. ::::: .::
CCDS62 NPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMA
               90       100       110       120       130       140

         100       110        120       130       140       150    
pF1KE0 RKLIHLEIKPAIRNQIIRELQV-LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQV
        : :.  .    ..:.. .:.: ..  . :::: ::::.. .:.  :::: :.  :.:. 
CCDS62 VKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMST-SFDKF
              150       160       170       180       190          

          160            170       180       190       200         
pF1KE0 LKKAGR-----IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDF
        : .       :::.::::...:..:.:..:.:. ::.:::.::::::..  :.::::::
CCDS62 YKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDF
     200       210       220       230       240       250         

     210       220        230           240       250       260    
pF1KE0 GVSGQLIDSMANSF-VGTRSYMSPERLQGTH----YSVQSDIWSMGLSLVEMAVGRYPIP
       :.::::.::.:..  .: : ::.:::.. .     :.:.::.::.:..: :.:.::.: :
CCDS62 GISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYP
     260       270       280       290       300       310         

          270       280       290       300       310       320    
pF1KE0 PPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPK
         ..                                         .:. :  .:.  ::.
CCDS62 KWNS-----------------------------------------VFDQLTQVVKGDPPQ
     320                                                330        

             330       340       350       360       370       380 
pF1KE0 LPSGV---FSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL
       : ..    ::  : .::: :: :. ..:   :.:. : ::   . . :. : ..:. .  
CCDS62 LSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILD-
      340       350       360       370       380       390        

             390    
pF1KE0 NQPSTPTHAAGV 
       ..:.::.      
CCDS62 QMPATPSSPMYVD
       400       410

>>CCDS11218.1 MAP2K3 gene_id:5606|Hs108|chr17             (318 aa)
 initn: 728 init1: 272 opt: 608  Z-score: 421.1  bits: 86.4 E(32554): 3.9e-17
Smith-Waterman score: 710; 36.7% identity (63.3% similar) in 338 aa overlap (53-380:20-315)

             30        40        50        60        70        80  
pF1KE0 TSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVV
                                     :.:  ..  :.. ::.  ::::: :  :::
CCDS11            MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVV
                          10        20        30        40         

             90       100       110        120       130       140 
pF1KE0 FKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV-LHECNSPYIVGFYGAFYSDGEISI
        :: :  :: .:: : :.  ..   ..... .:.. ..  .  : : ::::.. .:.. :
CCDS11 EKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWI
      50        60        70        80        90       100         

             150           160       170       180       190       
pF1KE0 CMEHMDGGSLDQ----VLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNIL
       ::: ::  :::.    :: :   :::.:::.........: .:. : ...::::::::.:
CCDS11 CMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVL
     110        120       130       140       150       160        

       200       210       220        230           240       250  
pF1KE0 VNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPER----LQGTHYSVQSDIWSMGLS
       .:..:..:.::::.:: :.::.:... .: . ::.:::    :.   :.:.::.::.:..
CCDS11 INKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGIT
      170       180       190       200       210       220        

            260       270       280       290       300       310  
pF1KE0 LVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFE
       ..:::. :.:                            .. : :              :.
CCDS11 MIEMAILRFPY---------------------------ESWGTP--------------FQ
      230                                  240                     

            320       330       340       350       360       370  
pF1KE0 LLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFA
        :  .:.:: :.::.  :: :: ::. .:: :::::: .  .:: : :.    ....:.:
CCDS11 QLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIA
       250       260       270       280       290       300       

            380       390   
pF1KE0 GWLCSTIGLNQPSTPTHAAGV
       ...   .:             
CCDS11 AFVKEILGEDS          
       310                  

>>CCDS11217.1 MAP2K3 gene_id:5606|Hs108|chr17             (347 aa)
 initn: 728 init1: 272 opt: 608  Z-score: 420.7  bits: 86.5 E(32554): 4.1e-17
Smith-Waterman score: 710; 36.7% identity (63.3% similar) in 338 aa overlap (53-380:49-344)

             30        40        50        60        70        80  
pF1KE0 TSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVV
                                     :.:  ..  :.. ::.  ::::: :  :::
CCDS11 SKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVV
       20        30        40        50        60        70        

             90       100       110        120       130       140 
pF1KE0 FKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV-LHECNSPYIVGFYGAFYSDGEISI
        :: :  :: .:: : :.  ..   ..... .:.. ..  .  : : ::::.. .:.. :
CCDS11 EKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWI
       80        90       100       110       120       130        

             150           160       170       180       190       
pF1KE0 CMEHMDGGSLDQ----VLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNIL
       ::: ::  :::.    :: :   :::.:::.........: .:. : ...::::::::.:
CCDS11 CMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVL
      140        150       160       170       180       190       

       200       210       220        230           240       250  
pF1KE0 VNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPER----LQGTHYSVQSDIWSMGLS
       .:..:..:.::::.:: :.::.:... .: . ::.:::    :.   :.:.::.::.:..
CCDS11 INKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGIT
       200       210       220       230       240       250       

            260       270       280       290       300       310  
pF1KE0 LVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFE
       ..:::. :.:                            .. : :              :.
CCDS11 MIEMAILRFPY---------------------------ESWGTP--------------FQ
       260                                  270                    

            320       330       340       350       360       370  
pF1KE0 LLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFA
        :  .:.:: :.::.  :: :: ::. .:: :::::: .  .:: : :.    ....:.:
CCDS11 QLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIA
        280       290       300       310       320       330      

            380       390   
pF1KE0 GWLCSTIGLNQPSTPTHAAGV
       ...   .:             
CCDS11 AFVKEILGEDS          
        340                 




393 residues in 1 query   sequences
18511270 residues in 32554 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Wed Nov  2 18:11:25 2016 done: Wed Nov  2 18:11:26 2016
 Total Scan time:  3.080 Total Display time:  0.030

Function used was FASTA [36.3.4 Apr, 2011]
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