Result of FASTA (omim) for pF1KB5715
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB5715, 787 aa
  1>>>pF1KB5715 787 - 787 aa - 787 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.3135+/-0.000345; mu= 7.8695+/- 0.022
 mean_var=183.3291+/-36.780, 0's: 0 Z-trim(121.2): 37  B-trim: 0 in 0/55
 Lambda= 0.094724
 statistics sampled from 37465 (37509) to 37465 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.748), E-opt: 0.2 (0.44), width:  16
 Scan time: 13.760

The best scores are:                                      opt bits E(85289)
NP_005622 (OMIM: 601500,601707,605462) smoothened  ( 787) 5464 759.3 1.4e-218
XP_011514824 (OMIM: 601500,601707,605462) PREDICTE ( 657) 4563 636.1 1.4e-181
NP_003496 (OMIM: 603408) frizzled-1 [Homo sapiens] ( 647)  604 95.1   1e-18
NP_009128 (OMIM: 606147) frizzled-10 precursor [Ho ( 581)  545 87.0 2.5e-16
NP_003498 (OMIM: 603410) frizzled-7 precursor [Hom ( 574)  536 85.8 5.9e-16
NP_003459 (OMIM: 601723) frizzled-5 precursor [Hom ( 585)  535 85.6 6.6e-16
NP_001457 (OMIM: 600667) frizzled-2 precursor [Hom ( 565)  522 83.8 2.2e-15
NP_001158088 (OMIM: 603409,614157) frizzled-6 isof ( 674)  512 82.5 6.5e-15
NP_003497 (OMIM: 603409,614157) frizzled-6 isoform ( 706)  512 82.5 6.7e-15
NP_001158087 (OMIM: 603409,614157) frizzled-6 isof ( 706)  512 82.5 6.7e-15
NP_003499 (OMIM: 601766) frizzled-9 precursor [Hom ( 591)  489 79.3 5.2e-14
XP_016869330 (OMIM: 606143) PREDICTED: frizzled-3  ( 599)  479 78.0 1.3e-13
NP_665873 (OMIM: 606143) frizzled-3 precursor [Hom ( 666)  479 78.0 1.5e-13
NP_059108 (OMIM: 606143) frizzled-3 precursor [Hom ( 666)  479 78.0 1.5e-13
XP_016869333 (OMIM: 606143) PREDICTED: frizzled-3  ( 470)  467 76.3 3.5e-13
XP_016869332 (OMIM: 606143) PREDICTED: frizzled-3  ( 491)  467 76.3 3.6e-13
XP_016869331 (OMIM: 606143) PREDICTED: frizzled-3  ( 502)  467 76.3 3.7e-13
NP_036325 (OMIM: 133780,604579) frizzled-4 precurs ( 537)  463 75.8 5.6e-13
NP_114072 (OMIM: 606146) frizzled-8 precursor [Hom ( 694)  419 69.8 4.4e-11
NP_001304725 (OMIM: 603409,614157) frizzled-6 isof ( 401)  275 50.0 2.4e-05


>>NP_005622 (OMIM: 601500,601707,605462) smoothened homo  (787 aa)
 initn: 5464 init1: 5464 opt: 5464  Z-score: 4045.1  bits: 759.3 E(85289): 1.4e-218
Smith-Waterman score: 5464; 100.0% identity (100.0% similar) in 787 aa overlap (1-787:1-787)

               10        20        30        40        50        60
pF1KB5 MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 LSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWA
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 VIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTN
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 EVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 TGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB5 HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB5 RGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEW
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB5 ERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKA
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB5 TLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPV
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB5 AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAE
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB5 ISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWG
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB5 AGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTEL
              730       740       750       760       770       780

              
pF1KB5 MDADSDF
       :::::::
NP_005 MDADSDF
              

>>XP_011514824 (OMIM: 601500,601707,605462) PREDICTED: s  (657 aa)
 initn: 4563 init1: 4563 opt: 4563  Z-score: 3380.8  bits: 636.1 E(85289): 1.4e-181
Smith-Waterman score: 4563; 100.0% identity (100.0% similar) in 657 aa overlap (131-787:1-657)

              110       120       130       140       150       160
pF1KB5 EAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERE
                                     ::::::::::::::::::::::::::::::
XP_011                               MPKCENDRVELPSRTLCQATRGPCAIVERE
                                             10        20        30

              170       180       190       200       210       220
pF1KB5 RGWPDFLRCTPDRFPEGCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGWPDFLRCTPDRFPEGCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNP
               40        50        60        70        80        90

              230       240       250       260       270       280
pF1KB5 LFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIG
              100       110       120       130       140       150

              290       300       310       320       330       340
pF1KB5 WLAQFMDGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WLAQFMDGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWH
              160       170       180       190       200       210

              350       360       370       380       390       400
pF1KB5 TSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYR
              220       230       240       250       260       270

              410       420       430       440       450       460
pF1KB5 AGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAF
              280       290       300       310       320       330

              470       480       490       500       510       520
pF1KB5 GFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKI
              340       350       360       370       380       390

              530       540       550       560       570       580
pF1KB5 NLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELL
              400       410       420       430       440       450

              590       600       610       620       630       640
pF1KB5 QNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVT
              460       470       480       490       500       510

              650       660       670       680       690       700
pF1KB5 PVATPVPPEEQANLWLVEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVATPVPPEEQANLWLVEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPST
              520       530       540       550       560       570

              710       720       730       740       750       760
pF1KB5 IPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAH
              580       590       600       610       620       630

              770       780       
pF1KB5 GRRQGLGPIHSRTNLMDTELMDADSDF
       :::::::::::::::::::::::::::
XP_011 GRRQGLGPIHSRTNLMDTELMDADSDF
              640       650       

>>NP_003496 (OMIM: 603408) frizzled-1 [Homo sapiens]      (647 aa)
 initn: 422 init1: 258 opt: 604  Z-score: 456.9  bits: 95.1 E(85289): 1e-18
Smith-Waterman score: 715; 27.4% identity (54.7% similar) in 623 aa overlap (17-559:56-644)

                             10        20           30        40   
pF1KB5               MAAARPARGPELPLLGLLLLLLLGDP---GRGAASSGNATGPGPRS
                                     :::: ::  :   :  : ..:.. : ::  
NP_003 LSARLAEEGSGDAGGRRRPPVDPRRLARQLLLLLWLLEAPLLLGVRAQAAGQGPGQGP--
          30        40        50        60        70        80     

            50        60                     70        80        90
pF1KB5 AGGSARRSAAVTGPPPPLSHC---------GRAAP----CEPLRYNVCLGSVLPYGATST
         : ...      :::: ..          : ..:    :.:.   .:   .       .
NP_003 --GPGQQP-----PPPPQQQQSGQQYNGERGISVPDHGYCQPISIPLCTDIAYNQTIMPN
                   90       100       110       120       130      

              100       110       120       130       140          
pF1KB5 LLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPS-RTLCQA
       :: : .. ::.:  ..  .  : .. .: : .. .::..: : :   .  ::  :.::. 
NP_003 LL-GHTN-QEDAGLEVHQFYPLVKV-QCSAELKFFLCSMYAPVCTVLEQALPPCRSLCER
         140        150        160       170       180       190   

     150       160         170            180       190       200  
pF1KB5 TRGPCAIVERERG--WPDFLRCTPDRFP-----EGCTNEVQNIKFNSSGQCEVPLVRTDN
       .:  :  .  . :  ::: :.:  ..::     : :...  . : ..     .:   :.:
NP_003 ARQGCEALMNKFGFQWPDTLKC--EKFPVHGAGELCVGQNTSDK-GTPTPSLLPEFWTSN
           200       210         220       230        240       250

                                               210       220       
pF1KB5 PK-------------------------------SW----YEDVEGCGIQCQNP------L
       :.                               :.    .   . ::  :.         
NP_003 PQHGGGGHRGGFPGGAGASERGKFSCPRALKVPSYLNYHFLGEKDCGAPCEPTKVYGLMY
              260       270       280       290       300       310

             230       240       250       260       270       280 
pF1KB5 FTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGW
       :   : .  ...:. ....    ::::. :...: :  . ::   ......:. . ....
NP_003 FGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFS-YPERPIIFLSGCYTAVAVAY
              320       330       340        350       360         

             290           300       310       320       330       
pF1KB5 LAQFMDGARREIVCR----ADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTY
       .: :.   :  .::      ::.  ... :..:  .:.:.:...:.  ::. .:.:.:. 
NP_003 IAGFLLEDR--VVCNDKFAEDGARTVAQGTKKE--GCTILFMMLYFFSMASSIWWVILSL
     370         380       390       400         410       420     

       340       350         360       370       380       390     
pF1KB5 AWHTSFKALGTTY--QPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYK
       .:   : : :  .  . . ....:::: .:..: . :..:::..::::: .::.:::: .
NP_003 TW---FLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLN
            430       440       450       460       470       480  

         400       410       420       430         440       450   
pF1KB5 NYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKS--NHPGLLSEKAASKINETMLRLG
       :     ::::::. . :..:  ::. : ..:: :..  .: :  .::    ... :.:.:
NP_003 NVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEK----LEKLMVRIG
            490       500       510       520           530        

           460       470       480             490        500      
pF1KB5 IFGFLAFGFVLITFSCHFYDFFNQAEWERSF-----RDYVL-C-QANVTIGLPTKQPIPD
       .:. :    . :...:.::.   . .::::.     ..:.. : . ..  : : . :.  
NP_003 VFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQAGGGAPPHPPMS-
      540       550       560       570       580       590        

        510       520       530       540       550       560      
pF1KB5 CEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKRIKKS
             :.. :  :. .  . .::. . :.:.  ::  ::. . :::.... :       
NP_003 ------PDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV    
             600       610       620       630       640           

        570       580       590       600       610       620      
pF1KB5 KMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMV

>>NP_009128 (OMIM: 606147) frizzled-10 precursor [Homo s  (581 aa)
 initn: 404 init1: 228 opt: 545  Z-score: 414.0  bits: 87.0 E(85289): 2.5e-16
Smith-Waterman score: 632; 26.7% identity (54.2% similar) in 581 aa overlap (39-571:4-558)

       10        20        30        40             50        60   
pF1KB5 GPELPLLGLLLLLLLGDPGRGAASSGNATGPGPR-----SAGGSARRSAAVTGPPPPLSH
                                     ::::     .. ::    ::...       
NP_009                            MQRPGPRLWLVLQVMGS---CAAISSMDMERPG
                                          10           20        30

            70        80        90       100       110       120   
pF1KB5 CGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQ
        :.   :.:..  .:    . :. :        ..:.::  .:  .. : .   : . ..
NP_009 DGK---CQPIEIPMCKD--IGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYG-CHGHLR
                  40          50        60        70         80    

           130        140        150       160         170         
pF1KB5 PLLCAVYMPKC-ENDRVELPS-RTLCQATRGPCAIVERERG--WPDFLRCT--PDRF-PE
        .::..: : : :.  . .:. :..:. .:  :. . .. .  ::: : :   :..  :.
NP_009 FFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPN
           90       100       110       120       130       140    

        180           190       200       210            220       
pF1KB5 GCTNEVQNIKFN----SSGQCEVPLVRTDNPKSWYEDV-----EGCGIQCQNP-LFTEAE
           :. :   .    .::    :: : . :.:  :        : :  :.::  : ..:
NP_009 YLCMEAPNNGSDEPTRGSGLFP-PLFRPQRPHSAQEHPLKDGGPGRG-GCDNPGKFHHVE
          150       160        170       180       190        200  

                          230       240          250       260     
pF1KB5 H------------------QDMHSYIAAFGAVTGLC---TLFTLATFVADWRNSNRYPAV
       .                  .: .  .. ..  . ::   . ::. ::. :     :::  
NP_009 KSASCAPLCTPGVDVYWSREDKRFAVVWLAIWAVLCFFSSAFTVLTFLID-PARFRYPER
            210       220       230       240       250        260 

         270       280       290       300       310       320     
pF1KB5 ILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYAL
        ..... :. : :.:.: ... ::.  :.:  :. .      . :. .:...:...::  
NP_009 PIIFLSMCYCVYSVGYLIRLFAGAES-IACDRDSGQLYVIQEGLESTGCTLVFLVLYYFG
             270       280        290       300       310       320

         330       340       350         360       370       380   
pF1KB5 MAGVVWFVVLTYAWHTSFKALGTTY--QPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDG
       ::. .:.:::: .:   : : :  .  . . ...::::: .:..: : :. ::.. .: :
NP_009 MASSLWWVVLTLTW---FLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAG
              330          340       350       360       370       

           390       400       410       420       430       440   
pF1KB5 DSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAAS
       : ..:.:.::  .    .:::: :..  :..:  :.. : ..:: :.       . . ..
NP_009 DELTGVCYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVALFHIRRVMK--TGGENTD
       380       390       400       410       420         430     

           450       460       470       480       490       500   
pF1KB5 KINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQP
       :... :.:.:.:. :    .  ...:.::. .:.  : . .     :. :      ..  
NP_009 KLEKLMVRIGLFSVLYTVPATCVIACYFYERLNMDYW-KILAAQHKCKMN------NQTK
         440       450       460       470        480              

           510        520       530       540       550         560
pF1KB5 IPDCEIKNR-PSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWC--RLTGQSDDEP
         :: .    :.. .  ...: .. .::. . :.::. ::  :... :  ::  .:  .:
NP_009 TLDCLMAASIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQV-CSRRLKKKSRRKP
      490       500       510       520       530        540       

              570       580       590       600       610       620
pF1KB5 KRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQ
         .  :  : :                                                 
NP_009 ASVITSGGIYKKAQHPQKTHHGKYEIPAQSPTCV                          
       550       560       570       580                           

>>NP_003498 (OMIM: 603410) frizzled-7 precursor [Homo sa  (574 aa)
 initn: 367 init1: 248 opt: 536  Z-score: 407.5  bits: 85.8 E(85289): 5.9e-16
Smith-Waterman score: 685; 27.9% identity (55.0% similar) in 567 aa overlap (52-559:27-571)

              30        40        50        60            70       
pF1KB5 LLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPPLSHCGRAAP----CEPLRYNV
                                     .: .:  :  .. : ..:    :.:.   .
NP_003     MRDPGAAAPLSSLGLCALVLALLGALSAGAGAQPYHGEKGISVPDHGFCQPISIPL
                   10        20        30        40        50      

        80        90       100       110       120       130       
pF1KB5 CLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCEN-
       :   .       .:: : .. ::.:  ..  .  : .. .:   .. .::..: : :   
NP_003 CTDIAYNQTILPNLL-GHTN-QEDAGLEVHQFYPLVKV-QCSPELRFFLCSMYAPVCTVL
         60        70          80        90        100       110   

        140       150       160         170       180          190 
pF1KB5 DRVELPSRTLCQATRGPCAIVERERG--WPDFLRCTPDRFPEGCTNEV---QNIKFNSSG
       :..  : :.::. .:  :  .  . :  ::. :::  . ::   ..:.   :: . .:.:
NP_003 DQAIPPCRSLCERARQGCEALMNKFGFQWPERLRC--ENFPVHGAGEICVGQNTSDGSGG
           120       130       140         150       160       170 

             200                 210                               
pF1KB5 QCEVPLVRTDNP----------KSWYEDVEG---------------------------CG
           : .    :               : .:                           ::
NP_003 PGGGPTAYPTAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRFLGERDCG
             180       190       200       210       220       230 

              220         230       240       250       260        
pF1KB5 IQCQ----NPL--FTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILF
         :.    : :  : : :..  . ........    ::::. :...: :  . ::   ..
NP_003 APCEPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFS-YPERPII
             240       250       260       270       280        290

      270       280       290         300       310       320      
pF1KB5 YVNACFFVGSIGWLAQFMDGARREIVCR--ADGTMRLGEPTSNETLSCVIIFVIVYYALM
       ....:.:. ... .: :.   :   : :   ::   ... :..:  .:.:.:...:.  :
NP_003 FLSGCYFMVAVAHVAGFLLEDRAVCVERFSDDGYRTVAQGTKKE--GCTILFMVLYFFGM
              300       310       320       330         340        

        330       340       350         360       370       380    
pF1KB5 AGVVWFVVLTYAWHTSFKALGTTY--QPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGD
       :. .:.:.:. .:   : : :  .  . . ....:::: .:..: : :..:::..:::::
NP_003 ASSIWWVILSLTW---FLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGD
      350       360          370       380       390       400     

          390       400       410       420       430         440  
pF1KB5 SVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKS--NHPGLLSEKAA
        .::.:.:: ..     ::::::. . :..:  ::. : ..:: :..  .: :  .:   
NP_003 LLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTE---
         410       420       430       440       450       460     

            450       460       470       480       490       500  
pF1KB5 SKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQ
        :... :.:.:.:. :    . :...:.::.   . .:::..    : :.  . ..:   
NP_003 -KLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTW----LLQTCKSYAVPC--
             470       480       490       500           510       

            510       520       530       540       550       560  
pF1KB5 PIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKR
       : :       :.. :  :. .  . .::. . :.:.  ::  ::: . ::. .:  :   
NP_003 P-PGHFPPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSHSSKGETAV
          520       530       540       550       560       570    

            570       580       590       600       610       620  
pF1KB5 IKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHV

>>NP_003459 (OMIM: 601723) frizzled-5 precursor [Homo sa  (585 aa)
 initn: 345 init1: 247 opt: 535  Z-score: 406.6  bits: 85.6 E(85289): 6.6e-16
Smith-Waterman score: 684; 27.6% identity (55.2% similar) in 554 aa overlap (66-566:29-547)

          40        50        60        70        80        90     
pF1KB5 ATGPGPRSAGGSARRSAAVTGPPPPLSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGD
                                     .:  :. .   .: :  . :. :      .
NP_003   MARPDPSAPPSLLLLLLAQLVGRAAAASKAPVCQEITVPMCRG--IGYNLTHMPNQFN
                 10        20        30        40          50      

         100         110       120       130         140       150 
pF1KB5 SDSQEEAHGKLV--LWSGLRNAPRCWAVIQPLLCAVYMPKCEND--RVELPSRTLCQATR
        :.:.:: :  :  .:  ..   .:   .. .::..: : :  :  .   : :..:. ..
NP_003 HDTQDEA-GLEVHQFWPLVE--IQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAK
         60         70          80        90       100       110   

             160         170        180                            
pF1KB5 GPCAIVERERG--WPDFLRCTPDRFPE-GCTNEVQNIKFN--------------------
       . :. . :. :  ::. . :  ::.:  :   ::  . .:                    
NP_003 AGCSPLMRQYGFAWPERMSC--DRLPVLGRDAEVLCMDYNRSEATTAPPRPFPAKPTLPG
           120       130         140       150       160       170 

            190                    200          210       220      
pF1KB5 ------SSGQCE-------------VPLVRTDNP---KSWYEDVEGCGIQCQNPLFTEAE
             :.:.:              ::... ..:   :    .: .:.. : .: :.  :
NP_003 PPGAPASGGECPAGGPFVCKCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQPSFSADE
             180       190       200       210       220       230 

        230       240       250       260       270       280      
pF1KB5 HQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFM
       .     .:. ....  . :  :.:::. : .   :::   .....::..  :.:.:....
NP_003 RTFATFWIGLWSVLCFISTSTTVATFLIDMERF-RYPERPIIFLSACYLCVSLGFLVRLV
             240       250       260        270       280       290

        290       300       310       320       330       340      
pF1KB5 DGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKAL
        : .  ..:  . . ..   :.. .: :.:.:..::.  ::. .:.:.:. .:   : : 
NP_003 VG-HASVACSREHN-HIHYETTGPAL-CTIVFLLVYFFGMASSIWWVILSLTW---FLAA
               300        310        320       330       340       

        350         360       370       380       390       400    
pF1KB5 GTTY--QPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFV
       :  .  . ..: ..:::: .: .: : ... ::...:::: :.:::.:: .:     :::
NP_003 GMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFV
          350       360       370       380       390       400    

          410       420       430         440       450       460  
pF1KB5 LAPIGLVLIVGGYFLIRGVMTLFSIKS--NHPGLLSEKAASKINETMLRLGIFGFLAFGF
       :.:. : :.::  ::. : ..:: :.:  .. :  ..:    ... :.:.::: .:    
NP_003 LGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDK----LEKLMIRIGIFTLLYTVP
          410       420       430       440           450       460

            470       480       490       500       510       520  
pF1KB5 VLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINL
       . :. .:..:.   .  :: .    . :   .  :  : ::      . .:   :  .. 
NP_003 ASIVVACYLYEQHYRESWEAA----LTC---ACPGHDTGQP------RAKPEYWVLMLKY
              470       480              490             500       

            530       540       550       560       570       580  
pF1KB5 FAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQN
       :  . .::. ..:.:.  :.  ::    :.:..   .:.: .::                
NP_003 FMCLVVGITSGVWIWSGKTVESWR----RFTSRCCCRPRRGHKSGGAMAAGDYPEASAAL
       510       520       530           540       550       560   

            590       600       610       620       630       640  
pF1KB5 PGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPV
                                                                   
NP_003 TGRTGPPGPAATYHKQVSLSHV                                      
           570       580                                           

>>NP_001457 (OMIM: 600667) frizzled-2 precursor [Homo sa  (565 aa)
 initn: 393 init1: 250 opt: 522  Z-score: 397.2  bits: 83.8 E(85289): 2.2e-15
Smith-Waterman score: 638; 26.1% identity (54.9% similar) in 567 aa overlap (56-559:21-562)

          30        40        50        60            70        80 
pF1KB5 PGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPPLSHCGRAAP----CEPLRYNVCLGS
                                     ::    .. : . :    :.:.   .:   
NP_001           MRPRSALPRLLLPLLLLPAAGPAQFHGEKGISIPDHGFCQPISIPLCTDI
                         10        20        30        40        50

              90       100       110       120       130        140
pF1KB5 VLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCEN-DRVE
       .       .:: : .. ::.:  ..  .  : .. .:   .. .::..: : :   ... 
NP_001 AYNQTIMPNLL-GHTN-QEDAGLEVHQFYPLVKV-QCSPELRFFLCSMYAPVCTVLEQAI
               60          70        80         90       100       

              150       160         170       180       190        
pF1KB5 LPSRTLCQATRGPCAIVERERG--WPDFLRCTPDRFPEGCTNEVQNIKFNSSGQCEVPLV
        : :..:. .:  :  .  . :  ::. :::  ..::.  ....  .  : : .    :.
NP_001 PPCRSICERARQGCEALMNKFGFQWPERLRC--EHFPRHGAEQI-CVGQNHSEDGAPALL
       110       120       130         140        150       160    

      200       210                                                
pF1KB5 RTDNPKSWYEDVEG------------------------------------------CGIQ
        :  : .    . :                                          :.  
NP_001 TTAPPPGLQPGAGGTPGGPGGGGAPPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAP
          170       180       190       200       210       220    

          220           230       240       250       260       270
pF1KB5 CQ--NP----LFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYV
       :.   :    .:.. : .  . .: .....    :.::..:...: .   :::   ....
NP_001 CEPARPDGSMFFSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQRF-RYPERPIIFL
          230       240       250       260       270        280   

              280       290           300       310       320      
pF1KB5 NACFFVGSIGWLAQFMDGARREIVCRA----DGTMRLGEPTSNETLSCVIIFVIVYYALM
       ..:. . :....: :.   :  .::      ::   . . :..:  .:.:.:...:.  :
NP_001 SGCYTMVSVAYIAGFVLQER--VVCNERFSEDGYRTVVQGTKKE--GCTILFMMLYFFSM
           290       300         310       320         330         

        330       340       350         360       370       380    
pF1KB5 AGVVWFVVLTYAWHTSFKALGTTY--QPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGD
       :. .:.:.:. .:   : : :  .  . . ....:::: .:..: : :..:::..:.:::
NP_001 ASSIWWVILSLTW---FLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGD
     340       350          360       370       380       390      

          390       400       410       420       430         440  
pF1KB5 SVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKS--NHPGLLSEKAA
        .::.:::: ..     ::::::. . :..:  ::. : ..:: :..  .: :  .::  
NP_001 LLSGVCFVGLNSLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEK--
        400       410       420       430       440       450      

            450       460       470       480       490       500  
pF1KB5 SKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQ
         ... :.:.:.:. :    . :...:.::.   . .::::. .   :.. ..:  :.. 
NP_001 --LERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVSQ-HCKS-LAIPCPAHY
            460       470       480       490        500        510

            510       520       530       540       550       560  
pF1KB5 PIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKR
         :    .  :.. :  :. .  . .::. . :.:.  ::  ::. . :::..   :   
NP_001 T-P----RMSPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRLTNSRHGETTV
                   520       530       540       550       560     

            570       580       590       600       610       620  
pF1KB5 IKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHV

>>NP_001158088 (OMIM: 603409,614157) frizzled-6 isoform   (674 aa)
 initn: 335 init1: 203 opt: 512  Z-score: 388.7  bits: 82.5 E(85289): 6.5e-15
Smith-Waterman score: 619; 27.8% identity (56.2% similar) in 454 aa overlap (118-545:37-471)

        90       100       110       120       130        140      
pF1KB5 TSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKC-ENDRVELPSRTL
                                     :   :. .:: ...: : :. .:  : : :
NP_001 MTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVPTCIEQIHVVPPCRKL
         10        20        30        40        50        60      

        150       160                  170            180       190
pF1KB5 CQATRGPCAIVERERG--WPDFLRC---------TPDRF-PE----GCTNEVQNIKFNSS
       :. . . :  .    :  ::. :.:         .:  : :.    :  ....... . .
NP_001 CEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVPVTFDPHTEFLGPQKKTEQVQRDIG
         70        80        90       100       110       120      

              200       210       220       230       240          
pF1KB5 GQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLC-TLFTL
         :   :  . .    .  .. :.  : :  :   : .  .:.:..  ..  :: ::::.
NP_001 FWCPRHLKTSGGQGYKFLGIDQCAPPCPNMYFKSDELEFAKSFIGTV-SIFCLCATLFTF
        130       140       150       160       170        180     

     250       260       270       280       290        300        
pF1KB5 ATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVC-RADGTMRLGEPT-
        ::. : :   :::   ..: ..:. . :. ..  :. :     .: .::  ..::. . 
NP_001 LTFLIDVRRF-RYPERPIIYYSVCYSIVSLMYFIGFLLGDST--ACNKADEKLELGDTVV
         190        200       210       220         230       240  

        310       320       330       340       350         360    
pF1KB5 -SNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTY--QPLSGKTSYFHLLT
        .... .:...:...:.  :::.::.:.:: .:   : : :  .  . .  :. .:: ..
NP_001 LGSQNKACTVLFMLLYFFTMAGTVWWVILTITW---FLAAGRKWSCEAIEQKAVWFHAVA
            250       260       270          280       290         

          370       380       390       400       410       420    
pF1KB5 WSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVM
       :. :  ::: .::. .:.::..::.::::  .      ::: :. : ..::  .:. :..
NP_001 WGTPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGII
     300       310       320       330       340       350         

          430         440       450       460       470       480  
pF1KB5 TLFSIKS--NHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWER
       .:  ...  .: :    .   :... :.:.:.:. : .  ..  ..:. :.  :.  :: 
NP_001 SLNHVRQVIQHDG----RNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEI
     360       370           380       390       400       410     

            490       500        510       520       530       540 
pF1KB5 SFRDYVLCQANVTIGLPTKQPIP-DCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKAT
       .. .    : ..        : : . . : :: : .  :. .  . .::.   :: .: :
NP_001 TWVSDHCRQYHI--------PCPYQAKAKARPELALFMIKYLMTLIVGISAVFWVGSKKT
         420               430       440       450       460       

             550       560       570       580       590       600 
pF1KB5 LLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVA
          :                                                        
NP_001 CTEWAGFFKRNRKRDPISESRRVLQESCEFFLKHNSKVKHKKKHYKPSSHKLKVISKSMG
       470       480       490       500       510       520       

>>NP_003497 (OMIM: 603409,614157) frizzled-6 isoform a p  (706 aa)
 initn: 335 init1: 203 opt: 512  Z-score: 388.5  bits: 82.5 E(85289): 6.7e-15
Smith-Waterman score: 633; 27.7% identity (54.7% similar) in 505 aa overlap (70-545:24-503)

      40        50        60        70        80         90        
pF1KB5 GPRSAGGSARRSAAVTGPPPPLSHCGRAAPCEPLRYNVCLGSVLPYGATS-TLLAGDSDS
                                     :::.    :.   . :. :    : :  : 
NP_003        MEMFTFLLTCIFLPLLRGHSLFTCEPITVPRCMK--MAYNMTFFPNLMGHYD-
                      10        20        30          40        50 

      100       110       120       130        140       150       
pF1KB5 QEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKC-ENDRVELPSRTLCQATRGPCAIV
       :  :  ..  .  : :  .:   :. .:: ...: : :. .:  : : ::. . . :  .
NP_003 QSIAAVEMEHFLPLANL-ECSPNIETFLCKAFVPTCIEQIHVVPPCRKLCEKVYSDCKKL
               60         70        80        90       100         

       160                  170            180       190       200 
pF1KB5 ERERG--WPDFLRC---------TPDRF-PE----GCTNEVQNIKFNSSGQCEVPLVRTD
           :  ::. :.:         .:  : :.    :  ....... . .  :   :  . 
NP_003 IDTFGIRWPEELECDRLQYCDETVPVTFDPHTEFLGPQKKTEQVQRDIGFWCPRHLKTSG
     110       120       130       140       150       160         

             210       220       230       240          250        
pF1KB5 NPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLC---TLFTLATFVADWRN
       .    .  .. :.  : :  :   : .  .:.:   :.:. .:   ::::. ::. : : 
NP_003 GQGYKFLGIDQCAPPCPNMYFKSDELEFAKSFI---GTVSIFCLCATLFTFLTFLIDVRR
     170       180       190       200          210       220      

      260       270       280       290        300         310     
pF1KB5 SNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVC-RADGTMRLGEPT--SNETLSCV
         :::   ..: ..:. . :. ..  :. :     .: .::  ..::. .  .... .:.
NP_003 F-RYPERPIIYYSVCYSIVSLMYFIGFLLGDS--TACNKADEKLELGDTVVLGSQNKACT
         230       240       250         260       270       280   

         320       330       340       350         360       370   
pF1KB5 IIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTY--QPLSGKTSYFHLLTWSLPFVLTV
       ..:...:.  :::.::.:.:: .:   : : :  .  . .  :. .:: ..:. :  :::
NP_003 VLFMLLYFFTMAGTVWWVILTITW---FLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTV
           290       300          310       320       330       340

           380       390       400       410       420       430   
pF1KB5 AILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKS--
        .::. .:.::..::.::::  .      ::: :. : ..::  .:. :...:  ...  
NP_003 MLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVI
              350       360       370       380       390       400

             440       450       460       470       480       490 
pF1KB5 NHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQ
       .: :    .   :... :.:.:.:. : .  ..  ..:. :.  :.  :: .. .    :
NP_003 QHDG----RNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQ
                  410       420       430       440       450      

             500        510       520       530       540       550
pF1KB5 ANVTIGLPTKQPIP-DCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWC
        ..        : : . . : :: : .  :. .  . .::.   :: .: :   :     
NP_003 YHI--------PCPYQAKAKARPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFK
                460       470       480       490       500        

              560       570       580       590       600       610
pF1KB5 RLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEP
                                                                   
NP_003 RNRKRDPISESRRVLQESCEFFLKHNSKVKHKKKHYKPSSHKLKVISKSMGTSTGATANH
      510       520       530       540       550       560        

>>NP_001158087 (OMIM: 603409,614157) frizzled-6 isoform   (706 aa)
 initn: 335 init1: 203 opt: 512  Z-score: 388.5  bits: 82.5 E(85289): 6.7e-15
Smith-Waterman score: 633; 27.7% identity (54.7% similar) in 505 aa overlap (70-545:24-503)

      40        50        60        70        80         90        
pF1KB5 GPRSAGGSARRSAAVTGPPPPLSHCGRAAPCEPLRYNVCLGSVLPYGATS-TLLAGDSDS
                                     :::.    :.   . :. :    : :  : 
NP_001        MEMFTFLLTCIFLPLLRGHSLFTCEPITVPRCMK--MAYNMTFFPNLMGHYD-
                      10        20        30          40        50 

      100       110       120       130        140       150       
pF1KB5 QEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKC-ENDRVELPSRTLCQATRGPCAIV
       :  :  ..  .  : :  .:   :. .:: ...: : :. .:  : : ::. . . :  .
NP_001 QSIAAVEMEHFLPLANL-ECSPNIETFLCKAFVPTCIEQIHVVPPCRKLCEKVYSDCKKL
               60         70        80        90       100         

       160                  170            180       190       200 
pF1KB5 ERERG--WPDFLRC---------TPDRF-PE----GCTNEVQNIKFNSSGQCEVPLVRTD
           :  ::. :.:         .:  : :.    :  ....... . .  :   :  . 
NP_001 IDTFGIRWPEELECDRLQYCDETVPVTFDPHTEFLGPQKKTEQVQRDIGFWCPRHLKTSG
     110       120       130       140       150       160         

             210       220       230       240          250        
pF1KB5 NPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLC---TLFTLATFVADWRN
       .    .  .. :.  : :  :   : .  .:.:   :.:. .:   ::::. ::. : : 
NP_001 GQGYKFLGIDQCAPPCPNMYFKSDELEFAKSFI---GTVSIFCLCATLFTFLTFLIDVRR
     170       180       190       200          210       220      

      260       270       280       290        300         310     
pF1KB5 SNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVC-RADGTMRLGEPT--SNETLSCV
         :::   ..: ..:. . :. ..  :. :     .: .::  ..::. .  .... .:.
NP_001 F-RYPERPIIYYSVCYSIVSLMYFIGFLLGDS--TACNKADEKLELGDTVVLGSQNKACT
         230       240       250         260       270       280   

         320       330       340       350         360       370   
pF1KB5 IIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTY--QPLSGKTSYFHLLTWSLPFVLTV
       ..:...:.  :::.::.:.:: .:   : : :  .  . .  :. .:: ..:. :  :::
NP_001 VLFMLLYFFTMAGTVWWVILTITW---FLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTV
           290       300          310       320       330       340

           380       390       400       410       420       430   
pF1KB5 AILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKS--
        .::. .:.::..::.::::  .      ::: :. : ..::  .:. :...:  ...  
NP_001 MLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVI
              350       360       370       380       390       400

             440       450       460       470       480       490 
pF1KB5 NHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQ
       .: :    .   :... :.:.:.:. : .  ..  ..:. :.  :.  :: .. .    :
NP_001 QHDG----RNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQ
                  410       420       430       440       450      

             500        510       520       530       540       550
pF1KB5 ANVTIGLPTKQPIP-DCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWC
        ..        : : . . : :: : .  :. .  . .::.   :: .: :   :     
NP_001 YHI--------PCPYQAKAKARPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFK
                460       470       480       490       500        

              560       570       580       590       600       610
pF1KB5 RLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEP
                                                                   
NP_001 RNRKRDPISESRRVLQESCEFFLKHNSKVKHKKKHYKPSSHKLKVISKSMGTSTGATANH
      510       520       530       540       550       560        




787 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 20:35:37 2016 done: Sat Nov  5 20:35:39 2016
 Total Scan time: 13.760 Total Display time:  0.160

Function used was FASTA [36.3.4 Apr, 2011]
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