Result of FASTA (omim) for
pF1KE3637
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3637, 518 aa
1>>>pF1KE3637 518 - 518 aa - 518 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.8311+/-0.000379; mu= 7.3582+/- 0.024
mean_var=158.6327+/-31.510, 0's: 0 Z-trim(118.8): 390 B-trim: 292 in 1/49
Lambda= 0.101831
statistics sampled from 31658 (32067) to 31658 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.729), E-opt: 0.2 (0.376), width: 16
Scan time: 8.200
The best scores are: opt bits E(85289)
NP_005051 (OMIM: 602943,616622) nuclear receptor R ( 518) 3535 531.3 2.6e-150
XP_006711547 (OMIM: 602943,616622) PREDICTED: nucl ( 651) 3443 517.9 3.6e-146
NP_001001523 (OMIM: 602943,616622) nuclear recepto ( 497) 3382 508.8 1.5e-143
XP_011520181 (OMIM: 600825) PREDICTED: nuclear rec ( 376) 950 151.5 4.2e-36
XP_016877956 (OMIM: 600825) PREDICTED: nuclear rec ( 386) 950 151.5 4.3e-36
XP_011520180 (OMIM: 600825) PREDICTED: nuclear rec ( 386) 950 151.5 4.3e-36
XP_016877955 (OMIM: 600825) PREDICTED: nuclear rec ( 460) 950 151.5 4.9e-36
XP_011520179 (OMIM: 600825) PREDICTED: nuclear rec ( 467) 950 151.5 5e-36
NP_599024 (OMIM: 600825) nuclear receptor ROR-alph ( 468) 950 151.5 5e-36
XP_005254641 (OMIM: 600825) PREDICTED: nuclear rec ( 477) 950 151.5 5.1e-36
XP_011520177 (OMIM: 600825) PREDICTED: nuclear rec ( 504) 950 151.6 5.3e-36
NP_599023 (OMIM: 600825) nuclear receptor ROR-alph ( 523) 950 151.6 5.4e-36
XP_011520176 (OMIM: 600825) PREDICTED: nuclear rec ( 525) 950 151.6 5.5e-36
NP_002934 (OMIM: 600825) nuclear receptor ROR-alph ( 548) 950 151.6 5.6e-36
NP_599022 (OMIM: 600825) nuclear receptor ROR-alph ( 556) 950 151.6 5.7e-36
NP_008845 (OMIM: 601972) nuclear receptor ROR-beta ( 459) 877 140.8 8.3e-33
NP_068370 (OMIM: 602408) nuclear receptor subfamil ( 614) 434 75.8 4.1e-13
XP_006713514 (OMIM: 602304) PREDICTED: nuclear rec ( 448) 421 73.8 1.2e-12
NP_001138897 (OMIM: 602304) nuclear receptor subfa ( 504) 421 73.8 1.3e-12
NP_005117 (OMIM: 602304) nuclear receptor subfamil ( 579) 421 73.9 1.5e-12
NP_001036193 (OMIM: 180190) retinoic acid receptor ( 443) 410 72.2 3.6e-12
NP_000957 (OMIM: 180190) retinoic acid receptor ga ( 454) 410 72.2 3.7e-12
NP_001277195 (OMIM: 180220,615524) retinoic acid r ( 399) 408 71.9 4.1e-12
NP_001317544 (OMIM: 125853,601487,601665,604367,60 ( 250) 403 71.0 4.7e-12
XP_011532146 (OMIM: 125853,601487,601665,604367,60 ( 250) 403 71.0 4.7e-12
XP_011532145 (OMIM: 125853,601487,601665,604367,60 ( 278) 403 71.0 5.1e-12
NP_001230659 (OMIM: 180190) retinoic acid receptor ( 382) 403 71.1 6.6e-12
XP_011532144 (OMIM: 125853,601487,601665,604367,60 ( 445) 403 71.2 7.4e-12
NP_005028 (OMIM: 125853,601487,601665,604367,60933 ( 477) 403 71.2 7.8e-12
NP_619726 (OMIM: 125853,601487,601665,604367,60933 ( 477) 403 71.2 7.8e-12
NP_619725 (OMIM: 125853,601487,601665,604367,60933 ( 477) 403 71.2 7.8e-12
XP_011532143 (OMIM: 125853,601487,601665,604367,60 ( 477) 403 71.2 7.8e-12
NP_056953 (OMIM: 125853,601487,601665,604367,60933 ( 505) 403 71.2 8.2e-12
NP_001277229 (OMIM: 180220,615524) retinoic acid r ( 405) 400 70.7 9.3e-12
NP_001277206 (OMIM: 180220,615524) retinoic acid r ( 402) 398 70.4 1.1e-11
XP_005269190 (OMIM: 601529) PREDICTED: nuclear rec ( 598) 401 71.0 1.2e-11
NP_000956 (OMIM: 180220,615524) retinoic acid rece ( 448) 398 70.4 1.2e-11
NP_001277145 (OMIM: 180220,615524) retinoic acid r ( 455) 398 70.4 1.3e-11
NP_001278918 (OMIM: 180246) retinoic acid receptor ( 347) 393 69.6 1.7e-11
XP_016866665 (OMIM: 180246) PREDICTED: retinoic ac ( 414) 393 69.7 1.9e-11
XP_011513098 (OMIM: 180246) PREDICTED: retinoic ac ( 420) 393 69.7 2e-11
XP_005249335 (OMIM: 180246) PREDICTED: retinoic ac ( 441) 393 69.7 2e-11
NP_001278850 (OMIM: 180245) retinoic acid receptor ( 365) 391 69.3 2.1e-11
NP_068811 (OMIM: 180246) retinoic acid receptor RX ( 533) 393 69.8 2.4e-11
NP_001257330 (OMIM: 180246) retinoic acid receptor ( 537) 393 69.8 2.4e-11
NP_001278849 (OMIM: 180245) retinoic acid receptor ( 435) 391 69.4 2.5e-11
NP_002948 (OMIM: 180245) retinoic acid receptor RX ( 462) 391 69.4 2.6e-11
NP_003288 (OMIM: 601529) nuclear receptor subfamil ( 603) 393 69.8 2.6e-11
NP_066285 (OMIM: 107773,615779) COUP transcription ( 414) 389 69.1 2.9e-11
XP_005257609 (OMIM: 180240,612376) PREDICTED: reti ( 478) 390 69.3 3e-11
>>NP_005051 (OMIM: 602943,616622) nuclear receptor ROR-g (518 aa)
initn: 3535 init1: 3535 opt: 3535 Z-score: 2819.6 bits: 531.3 E(85289): 2.6e-150
Smith-Waterman score: 3535; 100.0% identity (100.0% similar) in 518 aa overlap (1-518:1-518)
10 20 30 40 50 60
pF1KE3 MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
430 440 450 460 470 480
490 500 510
pF1KE3 ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
::::::::::::::::::::::::::::::::::::::
NP_005 ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
490 500 510
>>XP_006711547 (OMIM: 602943,616622) PREDICTED: nuclear (651 aa)
initn: 3443 init1: 3443 opt: 3443 Z-score: 2745.1 bits: 517.9 E(85289): 3.6e-146
Smith-Waterman score: 3443; 100.0% identity (100.0% similar) in 505 aa overlap (14-518:147-651)
10 20 30 40
pF1KE3 MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHY
::::::::::::::::::::::::::::::
XP_006 LVSCEHGGGKFEGQSHQAPGPPGGGRTGCLELLAAKKTHTSQIEVIPCKICGDKSSGIHY
120 130 140 150 160 170
50 60 70 80 90 100
pF1KE3 GVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKF
180 190 200 210 220 230
110 120 130 140 150 160
pF1KE3 GRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSS
240 250 260 270 280 290
170 180 190 200 210 220
pF1KE3 PDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQ
300 310 320 330 340 350
230 240 250 260 270 280
pF1KE3 LTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRE
360 370 380 390 400 410
290 300 310 320 330 340
pF1KE3 TCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFME
420 430 440 450 460 470
350 360 370 380 390 400
pF1KE3 LCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDF
480 490 500 510 520 530
410 420 430 440 450 460
pF1KE3 SHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSIL
540 550 560 570 580 590
470 480 490 500 510
pF1KE3 AKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
600 610 620 630 640 650
>>NP_001001523 (OMIM: 602943,616622) nuclear receptor RO (497 aa)
initn: 3382 init1: 3382 opt: 3382 Z-score: 2698.4 bits: 508.8 E(85289): 1.5e-143
Smith-Waterman score: 3382; 99.8% identity (100.0% similar) in 495 aa overlap (24-518:3-497)
10 20 30 40 50 60
pF1KE3 MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
.::::::::::::::::::::::::::::::::::::
NP_001 MRTQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
10 20 30
70 80 90 100 110 120
pF1KE3 CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE3 QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE3 GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE3 LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE3 SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE3 VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE3 TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
400 410 420 430 440 450
490 500 510
pF1KE3 ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
::::::::::::::::::::::::::::::::::::::
NP_001 ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
460 470 480 490
>>XP_011520181 (OMIM: 600825) PREDICTED: nuclear recepto (376 aa)
initn: 1082 init1: 785 opt: 950 Z-score: 769.2 bits: 151.5 E(85289): 4.2e-36
Smith-Waterman score: 987; 41.7% identity (68.1% similar) in 408 aa overlap (106-511:1-369)
80 90 100 110 120 130
pF1KE3 DRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVK
:::::::::.:::::. .:.::....
XP_011 MSKKQRDSLYAEVQKHRMQQQQRDHQ----
10 20
140 150 160 170 180 190
pF1KE3 TPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGL
: : . : : . :: . . .: .
XP_011 ---------------------QQPGEAEPLTPTYNISANGLTELHDDLSNY--------I
30 40 50
200 210 220 230 240 250
pF1KE3 NGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPS
.: ..:: .::.. : . : .::. :: .. . . . . . :
XP_011 DG------HTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCS
60 70 80 90 100 110
260 270 280 290 300 310
pF1KE3 FRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWE
: . .: .:..:.:::.:.. ::. :::: :.: . . : .::. .:: :.
XP_011 FTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREV
120 130 140 150 160 170
320 330 340 350 360 370
pF1KE3 MWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRT
::. :: ..:::::::::::::..:::::::::::::::::..:::..:::::....: :
XP_011 MWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNT
180 190 200 210 220 230
380 390 400 410 420 430
pF1KE3 VFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQE
:.:.:::.. ..:..::: ..:: .:.:..:: ..:..::::::..:.::..: : :::
XP_011 VYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQE
240 250 260 270 280 290
440 450 460 470 480 490
pF1KE3 KRKVEQLQYNLELAFHHHLCKTHRQS-ILAKLPPK-GKLRSLCSQHVERLQIFQHLHPIV
: :.:.:: ...::..: : :.::.. ::.:: : . ::.::..:.:.:. :. ..: .
XP_011 KVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDI
300 310 320 330 340 350
500 510
pF1KE3 VQAAFPPLYKELFSTETESPVGLSK
:. :::::::::..: :
XP_011 VRLHFPPLYKELFTSEFEPAMQIDG
360 370
>>XP_016877956 (OMIM: 600825) PREDICTED: nuclear recepto (386 aa)
initn: 1148 init1: 785 opt: 950 Z-score: 769.0 bits: 151.5 E(85289): 4.3e-36
Smith-Waterman score: 1053; 43.1% identity (68.9% similar) in 418 aa overlap (96-511:1-379)
70 80 90 100 110 120
pF1KE3 SCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQR
:::::::::::::::::::.:::::. .:.
XP_016 MSRDAVKFGRMSKKQRDSLYAEVQKHRMQQ
10 20 30
130 140 150 160 170 180
pF1KE3 QQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPS
::.... : : . : : . :: . . .
XP_016 QQRDHQ-------------------------QQPGEAEPLTPTYNISANGLTELHDDLSN
40 50 60
190 200 210 220 230 240
pF1KE3 YSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELG
: ..: ..:: .::.. : . : .::. :: .. . . .
XP_016 Y--------IDG------HTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYT
70 80 90 100 110
250 260 270 280 290 300
pF1KE3 QGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEV
. . :: . .: .:..:.:::.:.. ::. :::: :.: . . : .::.
XP_016 PASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEI
120 130 140 150 160 170
310 320 330 340 350 360
pF1KE3 TGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRM
.:: :. ::. :: ..:::::::::::::..:::::::::::::::::..:::..::
XP_016 ENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRM
180 190 200 210 220 230
370 380 390 400 410 420
pF1KE3 CRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVL
:::....: ::.:.:::.. ..:..::: ..:: .:.:..:: ..:..::::::..:.::
XP_016 CRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVL
240 250 260 270 280 290
430 440 450 460 470 480
pF1KE3 INAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQS-ILAKLPPK-GKLRSLCSQHVERL
..: : :::: :.:.:: ...::..: : :.::.. ::.:: : . ::.::..:.:.:
XP_016 MSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKL
300 310 320 330 340 350
490 500 510
pF1KE3 QIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
. :. ..: .:. :::::::::..: :
XP_016 MAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
360 370 380
>>XP_011520180 (OMIM: 600825) PREDICTED: nuclear recepto (386 aa)
initn: 1148 init1: 785 opt: 950 Z-score: 769.0 bits: 151.5 E(85289): 4.3e-36
Smith-Waterman score: 1053; 43.1% identity (68.9% similar) in 418 aa overlap (96-511:1-379)
70 80 90 100 110 120
pF1KE3 SCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQR
:::::::::::::::::::.:::::. .:.
XP_011 MSRDAVKFGRMSKKQRDSLYAEVQKHRMQQ
10 20 30
130 140 150 160 170 180
pF1KE3 QQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPS
::.... : : . : : . :: . . .
XP_011 QQRDHQ-------------------------QQPGEAEPLTPTYNISANGLTELHDDLSN
40 50 60
190 200 210 220 230 240
pF1KE3 YSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELG
: ..: ..:: .::.. : . : .::. :: .. . . .
XP_011 Y--------IDG------HTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYT
70 80 90 100 110
250 260 270 280 290 300
pF1KE3 QGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEV
. . :: . .: .:..:.:::.:.. ::. :::: :.: . . : .::.
XP_011 PASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEI
120 130 140 150 160 170
310 320 330 340 350 360
pF1KE3 TGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRM
.:: :. ::. :: ..:::::::::::::..:::::::::::::::::..:::..::
XP_011 ENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRM
180 190 200 210 220 230
370 380 390 400 410 420
pF1KE3 CRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVL
:::....: ::.:.:::.. ..:..::: ..:: .:.:..:: ..:..::::::..:.::
XP_011 CRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVL
240 250 260 270 280 290
430 440 450 460 470 480
pF1KE3 INAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQS-ILAKLPPK-GKLRSLCSQHVERL
..: : :::: :.:.:: ...::..: : :.::.. ::.:: : . ::.::..:.:.:
XP_011 MSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKL
300 310 320 330 340 350
490 500 510
pF1KE3 QIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
. :. ..: .:. :::::::::..: :
XP_011 MAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
360 370 380
>>XP_016877955 (OMIM: 600825) PREDICTED: nuclear recepto (460 aa)
initn: 1625 init1: 785 opt: 950 Z-score: 767.9 bits: 151.5 E(85289): 4.9e-36
Smith-Waterman score: 1530; 49.6% identity (72.9% similar) in 490 aa overlap (24-511:3-453)
10 20 30 40 50 60
pF1KE3 MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
.:::.:::::::::::::::::::::::::::::::.
XP_016 MNAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQ
10 20 30
70 80 90 100 110 120
pF1KE3 CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
::.::: ::.:: :::::::::::::::::::.::::::::::::::::::::.:::::
XP_016 SNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQK
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE3 QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
. .:.::.... : : . : : . :: .
XP_016 HRMQQQQRDHQ-------------------------QQPGEAEPLTPTYNISANGLTELH
100 110 120 130
190 200 210 220 230 240
pF1KE3 GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
. .: ..: ..:: .::.. : . : .::. :: .. .
XP_016 DDLSNY--------IDG------HTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEP
140 150 160 170 180
250 260 270 280 290 300
pF1KE3 LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
. . . . :: . .: .:..:.:::.:.. ::. :::: :.: . . :
XP_016 ICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTF
190 200 210 220 230 240
310 320 330 340 350 360
pF1KE3 SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
.::. .:: :. ::. :: ..:::::::::::::..:::::::::::::::::..::
XP_016 LQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEV
250 260 270 280 290 300
370 380 390 400 410 420
pF1KE3 VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
:..:::::....: ::.:.:::.. ..:..::: ..:: .:.:..:: ..:..::::::.
XP_016 VFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALF
310 320 330 340 350 360
430 440 450 460 470
pF1KE3 TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQS-ILAKLPPK-GKLRSLCSQ
.:.::..: : :::: :.:.:: ...::..: : :.::.. ::.:: : . ::.::..
XP_016 SAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGR
370 380 390 400 410 420
480 490 500 510
pF1KE3 HVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
:.:.:. :. ..: .:. :::::::::..: :
XP_016 HTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
430 440 450 460
>>XP_011520179 (OMIM: 600825) PREDICTED: nuclear recepto (467 aa)
initn: 1627 init1: 785 opt: 950 Z-score: 767.8 bits: 151.5 E(85289): 5e-36
Smith-Waterman score: 1532; 49.5% identity (72.6% similar) in 493 aa overlap (21-511:7-460)
10 20 30 40 50 60
pF1KE3 MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
: .:::.:::::::::::::::::::::::::::::::.
XP_011 MKFREGTAIAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQ
10 20 30 40
70 80 90 100 110 120
pF1KE3 CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
::.::: ::.:: :::::::::::::::::::.::::::::::::::::::::.:::::
XP_011 SNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQK
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE3 QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
. .:.::.... : : . : : . :: .
XP_011 HRMQQQQRDHQ-------------------------QQPGEAEPLTPTYNISANGLTELH
110 120 130 140
190 200 210 220 230 240
pF1KE3 GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
. .: ..: ..:: .::.. : . : .::. :: .. .
XP_011 DDLSNY--------IDG------HTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEP
150 160 170 180
250 260 270 280 290 300
pF1KE3 LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
. . . . :: . .: .:..:.:::.:.. ::. :::: :.: . . :
XP_011 ICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTF
190 200 210 220 230 240
310 320 330 340 350 360
pF1KE3 SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
.::. .:: :. ::. :: ..:::::::::::::..:::::::::::::::::..::
XP_011 LQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEV
250 260 270 280 290 300
370 380 390 400 410 420
pF1KE3 VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
:..:::::....: ::.:.:::.. ..:..::: ..:: .:.:..:: ..:..::::::.
XP_011 VFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALF
310 320 330 340 350 360
430 440 450 460 470
pF1KE3 TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQS-ILAKLPPK-GKLRSLCSQ
.:.::..: : :::: :.:.:: ...::..: : :.::.. ::.:: : . ::.::..
XP_011 SAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGR
370 380 390 400 410 420
480 490 500 510
pF1KE3 HVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
:.:.:. :. ..: .:. :::::::::..: :
XP_011 HTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
430 440 450 460
>>NP_599024 (OMIM: 600825) nuclear receptor ROR-alpha is (468 aa)
initn: 1625 init1: 785 opt: 950 Z-score: 767.8 bits: 151.5 E(85289): 5e-36
Smith-Waterman score: 1531; 49.3% identity (72.5% similar) in 499 aa overlap (15-511:5-461)
10 20 30 40 50 60
pF1KE3 MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
..:: : .:::.:::::::::::::::::::::::::::::::.
NP_599 MMYFVIAAMK---AQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQ
10 20 30 40
70 80 90 100 110 120
pF1KE3 CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
::.::: ::.:: :::::::::::::::::::.::::::::::::::::::::.:::::
NP_599 SNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQK
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE3 QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
. .:.::.... : : . : : . :: .
NP_599 HRMQQQQRDHQ-------------------------QQPGEAEPLTPTYNISANGLTELH
110 120 130 140
190 200 210 220 230 240
pF1KE3 GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
. .: ..: ..:: .::.. : . : .::. :: .. .
NP_599 DDLSNY--------IDG------HTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEP
150 160 170 180
250 260 270 280 290 300
pF1KE3 LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
. . . . :: . .: .:..:.:::.:.. ::. :::: :.: . . :
NP_599 ICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTF
190 200 210 220 230 240
310 320 330 340 350 360
pF1KE3 SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
.::. .:: :. ::. :: ..:::::::::::::..:::::::::::::::::..::
NP_599 LQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEV
250 260 270 280 290 300
370 380 390 400 410 420
pF1KE3 VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
:..:::::....: ::.:.:::.. ..:..::: ..:: .:.:..:: ..:..::::::.
NP_599 VFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALF
310 320 330 340 350 360
430 440 450 460 470
pF1KE3 TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQS-ILAKLPPK-GKLRSLCSQ
.:.::..: : :::: :.:.:: ...::..: : :.::.. ::.:: : . ::.::..
NP_599 SAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGR
370 380 390 400 410 420
480 490 500 510
pF1KE3 HVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
:.:.:. :. ..: .:. :::::::::..: :
NP_599 HTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
430 440 450 460
>>XP_005254641 (OMIM: 600825) PREDICTED: nuclear recepto (477 aa)
initn: 1661 init1: 785 opt: 950 Z-score: 767.7 bits: 151.5 E(85289): 5.1e-36
Smith-Waterman score: 1566; 50.3% identity (73.1% similar) in 495 aa overlap (19-511:15-470)
10 20 30 40 50 60
pF1KE3 MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
:::::::::.:::::::::::::::::::::::::::::::.
XP_005 MLTGSQSTFGISVTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQ
10 20 30 40 50
70 80 90 100 110 120
pF1KE3 CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
::.::: ::.:: :::::::::::::::::::.::::::::::::::::::::.:::::
XP_005 SNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQK
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE3 QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
. .:.::.... : : . : : . :: .
XP_005 HRMQQQQRDHQ-------------------------QQPGEAEPLTPTYNISANGLTELH
120 130 140 150
190 200 210 220 230 240
pF1KE3 GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
. .: ..: ..:: .::.. : . : .::. :: .. .
XP_005 DDLSNY--------IDG------HTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEP
160 170 180 190
250 260 270 280 290 300
pF1KE3 LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
. . . . :: . .: .:..:.:::.:.. ::. :::: :.: . . :
XP_005 ICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTF
200 210 220 230 240 250
310 320 330 340 350 360
pF1KE3 SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
.::. .:: :. ::. :: ..:::::::::::::..:::::::::::::::::..::
XP_005 LQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEV
260 270 280 290 300 310
370 380 390 400 410 420
pF1KE3 VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
:..:::::....: ::.:.:::.. ..:..::: ..:: .:.:..:: ..:..::::::.
XP_005 VFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALF
320 330 340 350 360 370
430 440 450 460 470
pF1KE3 TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQS-ILAKLPPK-GKLRSLCSQ
.:.::..: : :::: :.:.:: ...::..: : :.::.. ::.:: : . ::.::..
XP_005 SAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGR
380 390 400 410 420 430
480 490 500 510
pF1KE3 HVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
:.:.:. :. ..: .:. :::::::::..: :
XP_005 HTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
440 450 460 470
518 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 17:36:46 2016 done: Tue Nov 8 17:36:47 2016
Total Scan time: 8.200 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]