Result of FASTA (omim) for pF1KB6168
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB6168, 603 aa
  1>>>pF1KB6168 603 - 603 aa - 603 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 9.3869+/-0.000531; mu= 1.1078+/- 0.032
 mean_var=557.1001+/-126.461, 0's: 0 Z-trim(117.6): 1873  B-trim: 0 in 0/57
 Lambda= 0.054338
 statistics sampled from 27103 (29708) to 27103 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.69), E-opt: 0.2 (0.348), width:  16
 Scan time:  7.720

The best scores are:                                      opt bits E(85289)
NP_005021 (OMIM: 602098) serine/threonine-protein  ( 603) 4020 331.2 6.3e-90
NP_004064 (OMIM: 602913) serine/threonine-protein  ( 646) 1146 105.9 4.3e-22
NP_001239155 (OMIM: 607023) serine/threonine-prote ( 671) 1131 104.8   1e-21
NP_006613 (OMIM: 607023) serine/threonine-protein  ( 685) 1125 104.3 1.4e-21
XP_005262758 (OMIM: 605031,616171) PREDICTED: seri ( 936)  687 70.2 3.6e-11
XP_016863152 (OMIM: 605031,616171) PREDICTED: seri ( 937)  687 70.2 3.6e-11
NP_055079 (OMIM: 605031,616171) serine/threonine-p ( 970)  687 70.2 3.6e-11
XP_016863151 (OMIM: 605031,616171) PREDICTED: seri ( 971)  687 70.2 3.6e-11
NP_001177730 (OMIM: 605031,616171) serine/threonin ( 929)  639 66.4 4.8e-10
NP_001177728 (OMIM: 605031,616171) serine/threonin ( 938)  594 62.9 5.6e-09
NP_940839 (OMIM: 603072) aurora kinase A [Homo sap ( 403)  558 59.5 2.6e-08
NP_001310233 (OMIM: 603072) aurora kinase A [Homo  ( 403)  558 59.5 2.6e-08
NP_940836 (OMIM: 603072) aurora kinase A [Homo sap ( 403)  558 59.5 2.6e-08
NP_940835 (OMIM: 603072) aurora kinase A [Homo sap ( 403)  558 59.5 2.6e-08
NP_940838 (OMIM: 603072) aurora kinase A [Homo sap ( 403)  558 59.5 2.6e-08
NP_003591 (OMIM: 603072) aurora kinase A [Homo sap ( 403)  558 59.5 2.6e-08
NP_001310234 (OMIM: 603072) aurora kinase A [Homo  ( 403)  558 59.5 2.6e-08
NP_001310232 (OMIM: 603072) aurora kinase A [Homo  ( 403)  558 59.5 2.6e-08
XP_016883524 (OMIM: 603072) PREDICTED: aurora kina ( 403)  558 59.5 2.6e-08
NP_940837 (OMIM: 603072) aurora kinase A [Homo sap ( 403)  558 59.5 2.6e-08
XP_016883523 (OMIM: 603072) PREDICTED: aurora kina ( 437)  558 59.5 2.7e-08
XP_011527839 (OMIM: 606532) PREDICTED: hormonally  ( 698)  543 58.7 7.7e-08
NP_055401 (OMIM: 606532) hormonally up-regulated n ( 714)  543 58.7 7.8e-08
NP_055655 (OMIM: 608130) NUAK family SNF1-like kin ( 661)  534 58.0 1.2e-07
XP_005267700 (OMIM: 602678) PREDICTED: MAP/microtu ( 643)  519 56.8 2.7e-07
XP_016876782 (OMIM: 602678) PREDICTED: MAP/microtu ( 708)  519 56.8 2.8e-07
NP_001122392 (OMIM: 602678) MAP/microtubule affini ( 713)  519 56.8 2.9e-07
XP_016876781 (OMIM: 602678) PREDICTED: MAP/microtu ( 722)  519 56.8 2.9e-07
XP_016876780 (OMIM: 602678) PREDICTED: MAP/microtu ( 728)  519 56.8 2.9e-07
NP_002367 (OMIM: 602678) MAP/microtubule affinity- ( 729)  519 56.8 2.9e-07
XP_005267699 (OMIM: 602678) PREDICTED: MAP/microtu ( 737)  519 56.9 2.9e-07
XP_005267698 (OMIM: 602678) PREDICTED: MAP/microtu ( 738)  519 56.9 2.9e-07
XP_006720209 (OMIM: 602678) PREDICTED: MAP/microtu ( 739)  519 56.9 2.9e-07
NP_001122391 (OMIM: 602678) MAP/microtubule affini ( 744)  519 56.9 2.9e-07
NP_001122390 (OMIM: 602678) MAP/microtubule affini ( 753)  519 56.9 2.9e-07
XP_011541028 (OMIM: 614776) PREDICTED: serine/thre ( 660)  517 56.6 3.1e-07
NP_001273055 (OMIM: 606511) serine/threonine-prote ( 780)  513 56.4 4.1e-07
XP_005273191 (OMIM: 606511) PREDICTED: serine/thre ( 781)  513 56.4 4.1e-07
XP_011507863 (OMIM: 606511) PREDICTED: serine/thre ( 788)  513 56.4 4.2e-07
XP_016872913 (OMIM: 614776) PREDICTED: serine/thre (1213)  517 57.1 4.2e-07
NP_061120 (OMIM: 606511) serine/threonine-protein  ( 795)  513 56.4 4.2e-07
NP_001273053 (OMIM: 606511) serine/threonine-prote ( 796)  513 56.4 4.2e-07
XP_005271541 (OMIM: 614776) PREDICTED: serine/thre (1261)  517 57.1 4.3e-07
NP_001268678 (OMIM: 614776) serine/threonine-prote (1261)  517 57.1 4.3e-07
XP_011541024 (OMIM: 614776) PREDICTED: serine/thre (1309)  517 57.1 4.3e-07
XP_005271539 (OMIM: 614776) PREDICTED: serine/thre (1321)  517 57.1 4.4e-07
NP_079440 (OMIM: 614776) serine/threonine-protein  (1321)  517 57.1 4.4e-07
NP_001156769 (OMIM: 600526) serine/threonine-prote ( 709)  511 56.2 4.4e-07
NP_001156768 (OMIM: 600526) serine/threonine-prote ( 719)  511 56.2 4.4e-07
XP_005271538 (OMIM: 614776) PREDICTED: serine/thre (1369)  517 57.1 4.4e-07


>>NP_005021 (OMIM: 602098) serine/threonine-protein kina  (603 aa)
 initn: 4020 init1: 4020 opt: 4020  Z-score: 1735.5  bits: 331.2 E(85289): 6.3e-90
Smith-Waterman score: 4020; 100.0% identity (100.0% similar) in 603 aa overlap (1-603:1-603)

               10        20        30        40        50        60
pF1KB6 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB6 MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB6 NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB6 PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB6 YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB6 YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB6 LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL
              550       560       570       580       590       600

          
pF1KB6 KAS
       :::
NP_005 KAS
          

>>NP_004064 (OMIM: 602913) serine/threonine-protein kina  (646 aa)
 initn: 1380 init1: 1100 opt: 1146  Z-score: 517.6  bits: 105.9 E(85289): 4.3e-22
Smith-Waterman score: 1526; 40.7% identity (65.7% similar) in 632 aa overlap (9-589:15-643)

                     10        20        30           40        50 
pF1KB6       MSAAVTAGKLARAPADPGKAGVPGVAAPGAPA---AAPPAKEIPEVLVDPRSRR
                     . : ::: :.  : :  :  :      :. :...  ....:::: :
NP_004 MEPAAGFLSPRPFQRAAAAPAPPAGPGPPPSALRGPELEMLAGLPTSDPGRLITDPRSGR
               10        20        30        40        50        60

              60        70        80        90       100       110 
pF1KB6 RYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQ
        :..::.:::::::.:.: .:..:  ..: :..:.: . :::::::.  :: .::.: :.
NP_004 TYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHR
               70        80        90       100       110       120

             120       130       140       150       160       170 
pF1KB6 HVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNR
       :.: :   ::: : ... :::: :.:: .. : :..: :::.:::::::. : .:::.  
NP_004 HIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRG
              130       140       150       160       170       180

             180       190       200       210       220       230 
pF1KB6 VIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFE
       ..::::::::.:..:..:.:.::::::...:   .::::.::::::.::::: ..::. :
NP_004 ILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPE
              190       200       210       220       230       240

             240       250       260       270       280       290 
pF1KB6 VDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPT
       .::::.::.::::: :.:::::. :::::  ::. .:..:  ..  : .:.  .:...: 
NP_004 ADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPR
              250       260       270       280       290       300

             300       310        320       330        340         
pF1KB6 ARPTINELLNDEFFTSGYIPARLPIT-CLTIPPRFSIAPS-SLDPSNRKPLTVLNKGLEN
        ::.:...:  .:::.:: : ::::. :.:.:      :. ::  .  : :   .:  .:
NP_004 DRPSIDQILRHDFFTKGYTPDRLPISSCVTVPDLTPPNPARSLFAKVTKSLFGRKKKSKN
              310       320       330       340       350       360

     350                         360         370       380         
pF1KB6 PLPERPR------------------EKEEPVVRETGEV--VDCHLSDMLQQLHSVNASKP
          :: .                  . : :..   . :  :.    :   .   ....  
NP_004 HAQERDEVSGLVSGLMRTSVGHQDARPEAPAASGPAPVSLVETAPEDSSPRGTLASSGDG
              370       380       390       400       410       420

     390       400                             410       420       
pF1KB6 SERGLVRQEEAEDPACI----------------------PIFWVSKWVDYSDKYGLGYQL
        :.::.    .:.  :                       :. :::::::::.:.:.::::
NP_004 FEEGLTVATVVESALCALRNCIAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQL
              430       440       450       460       470       480

       430       440       450       460       470       480       
pF1KB6 CDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMS
        .  :.:::::.:.. :  .  ...:   .  .  ..:.. : .:. .. .:.:: .:: 
NP_004 SSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSVGAVPRALQPQLGILRYFASYME
              490       500       510       520       530       540

       490       500       510       520       530       540       
pF1KB6 EHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILC---
       .::.:.: ..   :  :.   : :  : .: .:... .:.:.::.::. :::::::    
NP_004 QHLMKGG-DLPSVEEVEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWE
               550       560       570       580       590         

          550       560       570       580        590       600   
pF1KB6 PLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYA-RTMVDKLLSSRSASNRLKAS
       ::.  ::.. ..:.  ::  : :.. ::  .: .::::: : . :.              
NP_004 PLL--VTFVARNRSACTYLASHLRQLGCSPDLRQRLRYALRLLRDRSPA           
     600         610       620       630       640                 

>>NP_001239155 (OMIM: 607023) serine/threonine-protein k  (671 aa)
 initn: 1493 init1: 1081 opt: 1131  Z-score: 511.0  bits: 104.8 E(85289): 1e-21
Smith-Waterman score: 1469; 38.9% identity (65.9% similar) in 628 aa overlap (12-571:33-650)

                                  10        20        30        40 
pF1KB6                    MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIP
                                     . : .: . . :    : . : .:::  : 
NP_001 LLRTITYQPAASTKMCEQALGKGCGADSKKKRPPQPPEESQP----PQSQAQVPPA--IS
             10        20        30        40            50        

              50        60        70        80        90       100 
pF1KB6 EVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSME
       ...::: . .:: ::. :::::::::.:..:  ...:.:.::.:.: . :::::::.. :
NP_001 RIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKE
         60        70        80        90       100       110      

             110       120       130       140       150       160 
pF1KB6 ISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIV
       : .:: : :.::: :. .:::.. ....:: : :::. .. : ::.:::::.::::::::
NP_001 IELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIV
        120       130       140       150       160       170      

             170       180       190       200       210       220 
pF1KB6 LGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPE
        : .:::.....::::::::.:.:: .:.:.::::::...:   .:..:.::::::..::
NP_001 SGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPE
        180       190       200       210       220       230      

             230       240       250       260       270       280 
pF1KB6 VLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASL
       ::.:.::. : :.:..::.:::.:.:.:::::. :::::  :.. .:..:. .   :  :
NP_001 VLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHL
        240       250       260       270       280       290      

             290       300       310       320        330          
pF1KB6 IQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIA-PSS---------
       : .::. .:  ::......  .:: .:. : ::  .:    : : .. :..         
NP_001 IASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAA
        300       310       320       330       340       350      

                             340             350       360         
pF1KB6 -----------LDPSNR-----KPLTVLNKGL------ENPLPERPREKEEP----VVRE
                  .:  ::     . .  : . :      ..:  .:  :. .:    :.: 
NP_001 LFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARS
        360       370       380       390       400       410      

         370         380                390                 400    
pF1KB6 TGEVVDC--HLSDMLQQ-----LHSVNAS----KPSERGLVRQ----------EEAEDPA
          .:.   ...: ...     : : ..:    . :  : : .          :.  .  
NP_001 GTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEAD
        420       430       440       450       460       470      

                 410       420       430       440       450       
pF1KB6 CIP-------IFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERD
       :::       . ::.::::::.:::.:::: :..::::::..... :  :  ...:  . 
NP_001 CIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAEL
        480       490       500       510       520       530      

       460       470       480       490       500         510     
pF1KB6 GTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLP--YLRTWF
       :  : . ... :.......:.:::: .:: :.:. .:    :   :   : :  ::  :.
NP_001 GQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGD--LPSVTD--IRRPRLYLLQWL
        540       550       560       570         580         590  

         520       530       540         550       560       570   
pF1KB6 RTRSAIILHLSNGSVQINFFQDHTKLILCPLMAA--VTYIDEKRDFRTYRLSLLEEYGCC
       .. .:... ...:. :.::..::::.:.:       .:::.: :   :.::. :   :  
NP_001 KSDKALMMLFNDGTFQVNFYHDHTKIIICSQNEEYLLTYINEDRISTTFRLTTLLMSGCS
            600       610       620       630       640       650  

           580       590       600   
pF1KB6 KELASRLRYARTMVDKLLSSRSASNRLKAS
                                     
NP_001 SELKNRMEYALNMLLQRCN           
            660       670            

>>NP_006613 (OMIM: 607023) serine/threonine-protein kina  (685 aa)
 initn: 1511 init1: 1099 opt: 1125  Z-score: 508.4  bits: 104.3 E(85289): 1.4e-21
Smith-Waterman score: 1463; 38.4% identity (65.3% similar) in 636 aa overlap (12-571:33-664)

                                  10        20        30           
pF1KB6                    MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAP------
                                     . : .: . . :  .   .: :::      
NP_006 LLRTITYQPAASTKMCEQALGKGCGADSKKKRPPQPPEESQPPQSQAQVPPAAPHHHHHH
             10        20        30        40        50        60  

            40        50        60        70        80        90   
pF1KB6 --PAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPH
          . :: ...::: . .:: ::. :::::::::.:..:  ...:.:.::.:.: . :::
NP_006 SHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPH
             70        80        90       100       110       120  

           100       110       120       130       140       150   
pF1KB6 QREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEA
       ::::.. :: .:: : :.::: :. .:::.. ....:: : :::. .. : ::.:::::.
NP_006 QREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEV
            130       140       150       160       170       180  

           160       170       180       190       200       210   
pF1KB6 RYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCG
       :::::::: : .:::.....::::::::.:.:: .:.:.::::::...:   .:..:.::
NP_006 RYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICG
            190       200       210       220       230       240  

           220       230       240       250       260       270   
pF1KB6 TPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKH
       ::::..::::.:.::. : :.:..::.:::.:.:.:::::. :::::  :.. .:..:. 
NP_006 TPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSS
            250       260       270       280       290       300  

           280       290       300       310       320        330  
pF1KB6 INPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIA-PSS-
       .   :  :: .::. .:  ::......  .:: .:. : ::  .:    : : .. :.. 
NP_006 LLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKN
            310       320       330       340       350       360  

                                     340             350       360 
pF1KB6 -------------------LDPSNR-----KPLTVLNKGL------ENPLPERPREKEEP
                          .:  ::     . .  : . :      ..:  .:  :. .:
NP_006 FFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQP
            370       380       390       400       410       420  

                 370         380                390                
pF1KB6 ----VVRETGEVVDC--HLSDMLQQ-----LHSVNAS----KPSERGLVRQ---------
           :.:    .:.   ...: ...     : : ..:    . :  : : .         
NP_006 PTTTVARSGTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLRGC
            430       440       450       460       470       480  

        400              410       420       430       440         
pF1KB6 -EEAEDPACIP-------IFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGD
        :.  .  :::       . ::.::::::.:::.:::: :..::::::..... :  :  
NP_006 LENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKK
            490       500       510       520       530       540  

     450       460       470       480       490       500         
pF1KB6 SLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLP
       ...:  . :  : . ... :.......:.:::: .:: :.:. .:    :   :   : :
NP_006 TVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGD--LPSVTD--IRRP
            550       560       570       580         590          

       510       520       530       540         550       560     
pF1KB6 --YLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAA--VTYIDEKRDFRTYRLS
         ::  :... .:... ...:. :.::..::::.:.:       .:::.: :   :.::.
NP_006 RLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQNEEYLLTYINEDRISTTFRLT
      600       610       620       630       640       650        

         570       580       590       600   
pF1KB6 LLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
        :   :                                
NP_006 TLLMSGCSSELKNRMEYALNMLLQRCN           
      660       670       680                

>>XP_005262758 (OMIM: 605031,616171) PREDICTED: serine/t  (936 aa)
 initn: 722 init1: 529 opt: 687  Z-score: 321.6  bits: 70.2 E(85289): 3.6e-11
Smith-Waterman score: 687; 37.7% identity (76.2% similar) in 252 aa overlap (56-306:15-266)

          30        40        50        60        70        80     
pF1KB6 AAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVP
                                     : .::::.::  ..  .  :    : :.. 
XP_005                 MATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMID
                               10        20        30        40    

          90       100       110       120       130       140     
pF1KB6 KSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLE-LHKR
       :. . :  . .... :..:: .: :  .. ....:::...:..:::.:.   . . :..:
XP_005 KKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNR
           50        60        70        80        90       100    

          150       160       170       180       190       200    
pF1KB6 RKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYD
        : ..: :::....::. :  ::: . ..:::: :.::.:......::.::::::.... 
XP_005 VKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMP
          110       120       130       140       150       160    

          210       220       230       240       250       260    
pF1KB6 GERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIK
        :.. :::::::::.::. ....:..: ::::.::..::::.:.:::.:. .:.:  .. 
XP_005 HEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV
          170       180       190       200       210       220    

          270       280       290       300       310       320    
pF1KB6 KNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPR
         .: .:. ..  : .::...:. .:. : ... .:.  :..                  
XP_005 LADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSID
          230       240       250       260       270       280    

          330       340       350       360       370       380    
pF1KB6 FSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSV
                                                                   
XP_005 SGHATISTAITASSSTSISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFY
          290       300       310       320       330       340    

>>XP_016863152 (OMIM: 605031,616171) PREDICTED: serine/t  (937 aa)
 initn: 722 init1: 529 opt: 687  Z-score: 321.6  bits: 70.2 E(85289): 3.6e-11
Smith-Waterman score: 687; 37.7% identity (76.2% similar) in 252 aa overlap (56-306:16-267)

          30        40        50        60        70        80     
pF1KB6 AAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVP
                                     : .::::.::  ..  .  :    : :.. 
XP_016                MPSTLDTCCIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMID
                              10        20        30        40     

          90       100       110       120       130       140     
pF1KB6 KSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLE-LHKR
       :. . :  . .... :..:: .: :  .. ....:::...:..:::.:.   . . :..:
XP_016 KKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNR
          50        60        70        80        90       100     

          150       160       170       180       190       200    
pF1KB6 RKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYD
        : ..: :::....::. :  ::: . ..:::: :.::.:......::.::::::.... 
XP_016 VKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMP
         110       120       130       140       150       160     

          210       220       230       240       250       260    
pF1KB6 GERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIK
        :.. :::::::::.::. ....:..: ::::.::..::::.:.:::.:. .:.:  .. 
XP_016 HEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV
         170       180       190       200       210       220     

          270       280       290       300       310       320    
pF1KB6 KNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPR
         .: .:. ..  : .::...:. .:. : ... .:.  :..                  
XP_016 LADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSID
         230       240       250       260       270       280     

          330       340       350       360       370       380    
pF1KB6 FSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSV
                                                                   
XP_016 SGHATISTAITASSSTSISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFY
         290       300       310       320       330       340     

>>NP_055079 (OMIM: 605031,616171) serine/threonine-prote  (970 aa)
 initn: 683 init1: 529 opt: 687  Z-score: 321.5  bits: 70.2 E(85289): 3.6e-11
Smith-Waterman score: 687; 37.7% identity (76.2% similar) in 252 aa overlap (56-306:15-266)

          30        40        50        60        70        80     
pF1KB6 AAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVP
                                     : .::::.::  ..  .  :    : :.. 
NP_055                 MATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMID
                               10        20        30        40    

          90       100       110       120       130       140     
pF1KB6 KSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLE-LHKR
       :. . :  . .... :..:: .: :  .. ....:::...:..:::.:.   . . :..:
NP_055 KKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNR
           50        60        70        80        90       100    

          150       160       170       180       190       200    
pF1KB6 RKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYD
        : ..: :::....::. :  ::: . ..:::: :.::.:......::.::::::.... 
NP_055 VKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMP
          110       120       130       140       150       160    

          210       220       230       240       250       260    
pF1KB6 GERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIK
        :.. :::::::::.::. ....:..: ::::.::..::::.:.:::.:. .:.:  .. 
NP_055 HEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV
          170       180       190       200       210       220    

          270       280       290       300       310       320    
pF1KB6 KNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPR
         .: .:. ..  : .::...:. .:. : ... .:.  :..                  
NP_055 LADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSID
          230       240       250       260       270       280    

          330       340       350       360       370       380    
pF1KB6 FSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSV
                                                                   
NP_055 SGHATISTAITASSSTSISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFY
          290       300       310       320       330       340    

>>XP_016863151 (OMIM: 605031,616171) PREDICTED: serine/t  (971 aa)
 initn: 683 init1: 529 opt: 687  Z-score: 321.5  bits: 70.2 E(85289): 3.6e-11
Smith-Waterman score: 687; 37.7% identity (76.2% similar) in 252 aa overlap (56-306:16-267)

          30        40        50        60        70        80     
pF1KB6 AAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVP
                                     : .::::.::  ..  .  :    : :.. 
XP_016                MPSTLDTCCIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMID
                              10        20        30        40     

          90       100       110       120       130       140     
pF1KB6 KSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLE-LHKR
       :. . :  . .... :..:: .: :  .. ....:::...:..:::.:.   . . :..:
XP_016 KKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNR
          50        60        70        80        90       100     

          150       160       170       180       190       200    
pF1KB6 RKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYD
        : ..: :::....::. :  ::: . ..:::: :.::.:......::.::::::.... 
XP_016 VKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMP
         110       120       130       140       150       160     

          210       220       230       240       250       260    
pF1KB6 GERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIK
        :.. :::::::::.::. ....:..: ::::.::..::::.:.:::.:. .:.:  .. 
XP_016 HEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV
         170       180       190       200       210       220     

          270       280       290       300       310       320    
pF1KB6 KNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPR
         .: .:. ..  : .::...:. .:. : ... .:.  :..                  
XP_016 LADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSID
         230       240       250       260       270       280     

          330       340       350       360       370       380    
pF1KB6 FSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSV
                                                                   
XP_016 SGHATISTAITASSSTSISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFY
         290       300       310       320       330       340     

>>NP_001177730 (OMIM: 605031,616171) serine/threonine-pr  (929 aa)
 initn: 618 init1: 529 opt: 639  Z-score: 301.3  bits: 66.4 E(85289): 4.8e-10
Smith-Waterman score: 639; 37.8% identity (78.7% similar) in 225 aa overlap (83-306:1-225)

             60        70        80        90       100       110  
pF1KB6 YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQH
                                     .. :. . :  . .... :..:: .: :  
NP_001                               MIDKKAMYKAGMVQRVQNEVKIHCQLKHPS
                                             10        20        30

            120       130       140        150       160       170 
pF1KB6 VVGFHGFFEDNDFVFVVLELCRRRSLLE-LHKRRKALTEPEARYYLRQIVLGCQYLHRNR
       .. ....:::...:..:::.:.   . . :..: : ..: :::....::. :  ::: . 
NP_001 ILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHG
               40        50        60        70        80        90

             180       190       200       210       220       230 
pF1KB6 VIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFE
       ..:::: :.::.:......::.::::::....  :.. :::::::::.::. ....:..:
NP_001 ILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLE
              100       110       120       130       140       150

             240       250       260       270       280       290 
pF1KB6 VDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPT
        ::::.::..::::.:.:::.:. .:.:  ..   .: .:. ..  : .::...:. .:.
NP_001 SDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPA
              160       170       180       190       200       210

             300       310       320       330       340       350 
pF1KB6 ARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPL
        : ... .:.  :..                                             
NP_001 DRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSIDSGHATISTAITASSSTSISGSLFDKRR
              220       230       240       250       260       270

>>NP_001177728 (OMIM: 605031,616171) serine/threonine-pr  (938 aa)
 initn: 530 init1: 530 opt: 594  Z-score: 282.2  bits: 62.9 E(85289): 5.6e-09
Smith-Waterman score: 594; 40.0% identity (79.5% similar) in 205 aa overlap (103-306:31-234)

             80        90       100       110       120       130  
pF1KB6 ADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLEL
                                     ::: .: .  .  ....:::...:..:::.
NP_001 MATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGL-EVAIKMLYNYFEDSNYVYLVLEM
               10        20        30         40        50         

            140        150       160       170       180       190 
pF1KB6 CRRRSLLE-LHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVK
       :.   . . :..: : ..: :::....::. :  ::: . ..:::: :.::.:......:
NP_001 CHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIK
      60        70        80        90       100       110         

             200       210       220       230       240       250 
pF1KB6 IGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPF
       :.::::::....  :.. :::::::::.::. ....:..: ::::.::..::::.:.:::
NP_001 IADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPF
     120       130       140       150       160       170         

             260       270       280       290       300       310 
pF1KB6 ETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIP
       .:. .:.:  ..   .: .:. ..  : .::...:. .:. : ... .:.  :..     
NP_001 DTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSST
     180       190       200       210       220       230         

             320       330       340       350       360       370 
pF1KB6 ARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVD
                                                                   
NP_001 KSKDLGTVEDSIDSGHATISTAITASSSTSISGSLFDKRRLLIGQPLPNKMTVFPKNKSS
     240       250       260       270       280       290         




603 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 13:39:39 2016 done: Sat Nov  5 13:39:40 2016
 Total Scan time:  7.720 Total Display time:  0.080

Function used was FASTA [36.3.4 Apr, 2011]
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