FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2684, 217 aa 1>>>pF1KE2684 217 - 217 aa - 217 aa Library: /omim/omim.rfq.tfa 61718354 residues in 86699 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3053+/-0.000294; mu= 13.8267+/- 0.019 mean_var=59.3135+/-11.796, 0's: 0 Z-trim(117.4): 28 B-trim: 0 in 0/57 Lambda= 0.166532 statistics sampled from 29631 (29659) to 29631 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.719), E-opt: 0.2 (0.342), width: 16 Scan time: 4.390 The best scores are: opt bits E(86699) NP_001959 (OMIM: 133440,615091) eukaryotic transla ( 217) 1492 366.2 2.4e-101 NP_001124150 (OMIM: 133440,615091) eukaryotic tran ( 237) 1454 357.1 1.4e-98 NP_001317946 (OMIM: 133440,615091) eukaryotic tran ( 245) 1454 357.1 1.5e-98 NP_001124151 (OMIM: 133440,615091) eukaryotic tran ( 248) 935 232.4 5.2e-61 NP_001263265 (OMIM: 605895) eukaryotic translation ( 234) 441 113.7 2.6e-25 NP_001317131 (OMIM: 605895) eukaryotic translation ( 240) 440 113.5 3.2e-25 NP_004837 (OMIM: 605895) eukaryotic translation in ( 245) 440 113.5 3.2e-25 NP_001269887 (OMIM: 605895) eukaryotic translation ( 236) 433 111.8 1e-24 NP_001263266 (OMIM: 605895) eukaryotic translation ( 189) 371 96.8 2.5e-20 NP_001317130 (OMIM: 605895) eukaryotic translation ( 200) 370 96.6 3.1e-20 NP_001317132 (OMIM: 605895) eukaryotic translation ( 191) 363 94.9 9.6e-20 NP_001128123 (OMIM: 609896) eukaryotic translation ( 224) 280 75.0 1.1e-13 NP_775495 (OMIM: 609896) eukaryotic translation in ( 118) 175 49.7 2.5e-06 NP_001128121 (OMIM: 609896) eukaryotic translation ( 118) 175 49.7 2.5e-06 XP_016861769 (OMIM: 609896) PREDICTED: eukaryotic ( 118) 175 49.7 2.5e-06 XP_016861771 (OMIM: 609896) PREDICTED: eukaryotic ( 118) 175 49.7 2.5e-06 XP_016861768 (OMIM: 609896) PREDICTED: eukaryotic ( 118) 175 49.7 2.5e-06 XP_016861770 (OMIM: 609896) PREDICTED: eukaryotic ( 118) 175 49.7 2.5e-06 XP_016861767 (OMIM: 609896) PREDICTED: eukaryotic ( 118) 175 49.7 2.5e-06 NP_001269815 (OMIM: 609896) eukaryotic translation ( 118) 175 49.7 2.5e-06 NP_001128122 (OMIM: 609896) eukaryotic translation ( 118) 175 49.7 2.5e-06 >>NP_001959 (OMIM: 133440,615091) eukaryotic translation (217 aa) initn: 1492 init1: 1492 opt: 1492 Z-score: 1940.6 bits: 366.2 E(86699): 2.4e-101 Smith-Waterman score: 1492; 99.5% identity (100.0% similar) in 217 aa overlap (1-217:1-217) 10 20 30 40 50 60 pF1KE2 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 QRRSDLNRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIG ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIG 130 140 150 160 170 180 190 200 210 pF1KE2 RVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV ::::::::::::::::::::::::::::::::::::: NP_001 RVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 190 200 210 >>NP_001124150 (OMIM: 133440,615091) eukaryotic translat (237 aa) initn: 1454 init1: 1454 opt: 1454 Z-score: 1890.7 bits: 357.1 E(86699): 1.4e-98 Smith-Waterman score: 1454; 99.5% identity (100.0% similar) in 211 aa overlap (7-217:27-237) 10 20 30 40 pF1KE2 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQ :::::::::::::::::::::::::::::::::: NP_001 MLDLTSRGQVGTSRRMAEAACSAHFLETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQ 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE2 NRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEP 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE2 MWEDEKNKRGGRWLITLNKQQRRSDLNRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKG ::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::: NP_001 MWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKG 130 140 150 160 170 180 170 180 190 200 210 pF1KE2 DKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 190 200 210 220 230 >>NP_001317946 (OMIM: 133440,615091) eukaryotic translat (245 aa) initn: 1454 init1: 1454 opt: 1454 Z-score: 1890.5 bits: 357.1 E(86699): 1.5e-98 Smith-Waterman score: 1454; 99.5% identity (100.0% similar) in 211 aa overlap (7-217:35-245) 10 20 30 pF1KE2 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIK :::::::::::::::::::::::::::::: NP_001 QNKKERKKMRAEDGENDAIKKQAESLRESQETTPTPNPPTTEEEKTESNQEVANPEHYIK 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE2 HPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKD 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE2 GIEPMWEDEKNKRGGRWLITLNKQQRRSDLNRFWLETLLCLIGESFDDYSDDVCGAVVNV ::::::::::::::::::::::::::::::.::::::::::::::::::::::::::::: NP_001 GIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNV 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE2 RAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFV 190 200 210 220 230 240 pF1KE2 V : NP_001 V >>NP_001124151 (OMIM: 133440,615091) eukaryotic translat (248 aa) initn: 1478 init1: 935 opt: 935 Z-score: 1216.5 bits: 232.4 E(86699): 5.2e-61 Smith-Waterman score: 1420; 87.1% identity (87.5% similar) in 248 aa overlap (1-217:1-248) 10 20 30 40 50 60 pF1KE2 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQ 70 80 90 100 110 120 130 140 pF1KE2 QRRSDLNRFWLET-------------------------------LLCLIGESFDDYSDDV ::::::.:::::: :::::::::::::::: NP_001 QRRSDLDRFWLETRWDLAMLPRLVSNFWPQVILPLQPPKVLELQLLCLIGESFDDYSDDV 130 140 150 160 170 180 150 160 170 180 190 200 pF1KE2 CGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGS 190 200 210 220 230 240 210 pF1KE2 TTKNRFVV :::::::: NP_001 TTKNRFVV >>NP_001263265 (OMIM: 605895) eukaryotic translation ini (234 aa) initn: 368 init1: 203 opt: 441 Z-score: 575.4 bits: 113.7 E(86699): 2.6e-25 Smith-Waterman score: 443; 33.8% identity (67.6% similar) in 207 aa overlap (18-213:29-229) 10 20 30 40 pF1KE2 MATVEPETTPTPNPPTTEEEKTE--SNQEVANPEHYI----KHPLQNRW :.:::: .:: .. . . .:::: . NP_001 MNNKFDALKDDDSGDHDQNEENSTQKDGEKEKTERDKNQSSSKRKAVVPGPAEHPLQYNY 10 20 30 40 50 60 50 60 70 80 90 pF1KE2 ALWFFKND-----KSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGI ..:. . .:.... :.. :. : .::.:: .:.:. ..: :. :::.:: NP_001 TFWYSRRTPGRPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGI 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE2 EPMWEDEKNKRGGRWLITLNKQQRRSDLNRFWLETLLCLIGESFDDYSDDVCGAVVNVRA .:::::. :: ::.:.: : :.. .: : . .: ..::.: ....:::::.:: NP_001 KPMWEDDANKNGGKWIIRL----RKGLASRCWENLILAMLGEQFM-VGEEICGAVVSVRF 130 140 150 160 170 160 170 180 190 200 210 pF1KE2 KGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV . : :.::. .. ....: . .. :.:::. .. :..:.:. :..:. .: NP_001 QEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHTDSI-KDNSSFRNTKITL 180 190 200 210 220 230 >>NP_001317131 (OMIM: 605895) eukaryotic translation ini (240 aa) initn: 364 init1: 203 opt: 440 Z-score: 574.0 bits: 113.5 E(86699): 3.2e-25 Smith-Waterman score: 442; 32.9% identity (65.7% similar) in 210 aa overlap (18-216:24-228) 10 20 30 40 pF1KE2 MATVEPETTPTPNPPTTEEEKTE--SNQEVANPEHYI----KHPLQNRWALWFF :.:::: .:: .. . . .:::: ...:. NP_001 MSLKDDDSGDHDQNEENSTQKDGEKEKTERDKNQSSSKRKAVVPGPAEHPLQYNYTFWYS 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE2 KND-----KSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWE . .:.... :.. :. : .::.:: .:.:. ..: :. :::.::.:::: NP_001 RRTPGRPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGIKPMWE 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE2 DEKNKRGGRWLITLNKQQRRSDLNRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKI :. :: ::.:.: : :.. .: : . .: ..::.: ....:::::.:: . : : NP_001 DDANKNGGKWIIRL----RKGLASRCWENLILAMLGEQFM-VGEEICGAVVSVRFQEDII 130 140 150 160 170 170 180 190 200 210 pF1KE2 AIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV .::. .. ....: . .. :.:::. .. :..:.:. : .:.. NP_001 SIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHTDSIKMPGRLGPQRLLFQNLWKP 180 190 200 210 220 230 NP_001 RLNVP 240 >>NP_004837 (OMIM: 605895) eukaryotic translation initia (245 aa) initn: 364 init1: 203 opt: 440 Z-score: 573.8 bits: 113.5 E(86699): 3.2e-25 Smith-Waterman score: 442; 32.9% identity (65.7% similar) in 210 aa overlap (18-216:29-233) 10 20 30 40 pF1KE2 MATVEPETTPTPNPPTTEEEKTE--SNQEVANPEHYI----KHPLQNRW :.:::: .:: .. . . .:::: . NP_004 MNNKFDALKDDDSGDHDQNEENSTQKDGEKEKTERDKNQSSSKRKAVVPGPAEHPLQYNY 10 20 30 40 50 60 50 60 70 80 90 pF1KE2 ALWFFKND-----KSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGI ..:. . .:.... :.. :. : .::.:: .:.:. ..: :. :::.:: NP_004 TFWYSRRTPGRPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGI 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE2 EPMWEDEKNKRGGRWLITLNKQQRRSDLNRFWLETLLCLIGESFDDYSDDVCGAVVNVRA .:::::. :: ::.:.: : :.. .: : . .: ..::.: ....:::::.:: NP_004 KPMWEDDANKNGGKWIIRL----RKGLASRCWENLILAMLGEQFM-VGEEICGAVVSVRF 130 140 150 160 170 160 170 180 190 200 210 pF1KE2 KGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV . : :.::. .. ....: . .. :.:::. .. :..:.:. : .:.. NP_004 QEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHTDSIKMPGRLGPQRLLFQ 180 190 200 210 220 230 NP_004 NLWKPRLNVP 240 >>NP_001269887 (OMIM: 605895) eukaryotic translation ini (236 aa) initn: 364 init1: 203 opt: 433 Z-score: 565.0 bits: 111.8 E(86699): 1e-24 Smith-Waterman score: 435; 34.0% identity (67.5% similar) in 197 aa overlap (18-203:29-220) 10 20 30 40 pF1KE2 MATVEPETTPTPNPPTTEEEKTE--SNQEVANPEHYI----KHPLQNRW :.:::: .:: .. . . .:::: . NP_001 MNNKFDALKDDDSGDHDQNEENSTQKDGEKEKTERDKNQSSSKRKAVVPGPAEHPLQYNY 10 20 30 40 50 60 50 60 70 80 90 pF1KE2 ALWFFKND-----KSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGI ..:. . .:.... :.. :. : .::.:: .:.:. ..: :. :::.:: NP_001 TFWYSRRTPGRPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGI 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE2 EPMWEDEKNKRGGRWLITLNKQQRRSDLNRFWLETLLCLIGESFDDYSDDVCGAVVNVRA .:::::. :: ::.:.: : :.. .: : . .: ..::.: ....:::::.:: NP_001 KPMWEDDANKNGGKWIIRL----RKGLASRCWENLILAMLGEQFM-VGEEICGAVVSVRF 130 140 150 160 170 160 170 180 190 200 210 pF1KE2 KGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV . : :.::. .. ....: . .. :.:::. .. :..:.:. NP_001 QEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHTDSIKAWEEFHGLVNSSG 180 190 200 210 220 230 NP_001 R >>NP_001263266 (OMIM: 605895) eukaryotic translation ini (189 aa) initn: 370 init1: 203 opt: 371 Z-score: 486.0 bits: 96.8 E(86699): 2.5e-20 Smith-Waterman score: 371; 36.2% identity (68.7% similar) in 163 aa overlap (51-213:29-184) 30 40 50 60 70 80 pF1KE2 KTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQ .: :: . . . :: ::.:: .:.:. NP_001 MNNKFDALKDDDSGDHDQNEENSTQKDGEKEKTERDKNQSSSK-RKVEQFWRFYSHMV 10 20 30 40 50 90 100 110 120 130 140 pF1KE2 LSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLNRFWLETLLCLIGE ..: :. :::.::.:::::. :: ::.:.: : :.. .: : . .: ..:: NP_001 RPGDLTGHSDFHLFKEGIKPMWEDDANKNGGKWIIRL----RKGLASRCWENLILAMLGE 60 70 80 90 100 110 150 160 170 180 190 200 pF1KE2 SFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSH .: ....:::::.:: . : :.::. .. ....: . .. :.:::. .. :..: NP_001 QFM-VGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTH 120 130 140 150 160 170 210 pF1KE2 ADTATKSGSTTKNRFVV .:. :..:. .: NP_001 TDSI-KDNSSFRNTKITL 180 >>NP_001317130 (OMIM: 605895) eukaryotic translation ini (200 aa) initn: 348 init1: 203 opt: 370 Z-score: 484.3 bits: 96.6 E(86699): 3.1e-20 Smith-Waterman score: 370; 34.9% identity (66.3% similar) in 166 aa overlap (51-216:29-188) 30 40 50 60 70 80 pF1KE2 KTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQ .: :: . . . :: ::.:: .:.:. NP_001 MNNKFDALKDDDSGDHDQNEENSTQKDGEKEKTERDKNQSSSK-RKVEQFWRFYSHMV 10 20 30 40 50 90 100 110 120 130 140 pF1KE2 LSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLNRFWLETLLCLIGE ..: :. :::.::.:::::. :: ::.:.: : :.. .: : . .: ..:: NP_001 RPGDLTGHSDFHLFKEGIKPMWEDDANKNGGKWIIRL----RKGLASRCWENLILAMLGE 60 70 80 90 100 110 150 160 170 180 190 200 pF1KE2 SFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSH .: ....:::::.:: . : :.::. .. ....: . .. :.:::. .. :..: NP_001 QFM-VGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTH 120 130 140 150 160 170 210 pF1KE2 ADTATKSGSTTKNRFVV .:. : .:.. NP_001 TDSIKMPGRLGPQRLLFQNLWKPRLNVP 180 190 200 217 residues in 1 query sequences 61718354 residues in 86699 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Apr 21 11:09:02 2017 done: Fri Apr 21 11:09:02 2017 Total Scan time: 4.390 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]