Result of FASTA (omim) for pF1KE1303
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE1303, 416 aa
  1>>>pF1KE1303     416 - 416 aa - 416 aa
Library: /omim/omim.rfq.tfa
  61989856 residues in 87180 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.8083+/-0.000309; mu= 15.1621+/- 0.019
 mean_var=80.9249+/-16.566, 0's: 0 Z-trim(117.0): 73  B-trim: 1503 in 1/49
 Lambda= 0.142572
 statistics sampled from 28889 (28983) to 28889 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.706), E-opt: 0.2 (0.332), width:  16
 Scan time:  9.360

The best scores are:                                      opt bits E(87180)
NP_001220 (OMIM: 602234) caspase-9 isoform alpha p ( 416) 2819 589.3 5.9e-168
XP_011540575 (OMIM: 602234) PREDICTED: caspase-9 i ( 421) 2641 552.7 6.3e-157
XP_005246071 (OMIM: 602234) PREDICTED: caspase-9 i ( 333) 2267 475.7 7.4e-134
NP_127463 (OMIM: 602234) caspase-9 isoform 3 [Homo ( 333) 2267 475.7 7.4e-134
NP_001264983 (OMIM: 602234) caspase-9 isoform beta ( 266)  918 198.2 2.1e-50
NP_116764 (OMIM: 600639) caspase-2 isoform 1 prepr ( 452)  437 99.4   2e-20
NP_001215 (OMIM: 600639) caspase-2 isoform 2 [Homo ( 312)  402 92.1 2.1e-18
NP_116786 (OMIM: 600636) caspase-3 preproprotein [ ( 277)  392 90.0   8e-18
NP_004337 (OMIM: 600636) caspase-3 preproprotein [ ( 277)  392 90.0   8e-18
XP_011530603 (OMIM: 600636) PREDICTED: caspase-3 i ( 277)  392 90.0   8e-18
XP_005246951 (OMIM: 114480,114550,211980,601763,60 ( 280)  392 90.0   8e-18
XP_011510271 (OMIM: 114480,114550,211980,601763,60 ( 334)  391 89.9 1.1e-17
NP_203520 (OMIM: 114480,114550,211980,601763,60727 ( 464)  391 89.9 1.4e-17
NP_001073593 (OMIM: 114480,114550,211980,601763,60 ( 464)  391 89.9 1.4e-17
XP_005246949 (OMIM: 114480,114550,211980,601763,60 ( 464)  391 89.9 1.4e-17
XP_005246944 (OMIM: 114480,114550,211980,601763,60 ( 479)  391 90.0 1.4e-17
XP_006712853 (OMIM: 114480,114550,211980,601763,60 ( 479)  391 90.0 1.4e-17
XP_005246946 (OMIM: 114480,114550,211980,601763,60 ( 479)  391 90.0 1.4e-17
NP_203519 (OMIM: 114480,114550,211980,601763,60727 ( 479)  391 90.0 1.4e-17
XP_005246947 (OMIM: 114480,114550,211980,601763,60 ( 479)  391 90.0 1.4e-17
XP_005246945 (OMIM: 114480,114550,211980,601763,60 ( 479)  391 90.0 1.4e-17
XP_005246948 (OMIM: 114480,114550,211980,601763,60 ( 479)  391 90.0 1.4e-17
XP_005246943 (OMIM: 114480,114550,211980,601763,60 ( 479)  391 90.0 1.4e-17
XP_006712852 (OMIM: 114480,114550,211980,601763,60 ( 479)  391 90.0 1.4e-17
NP_001219 (OMIM: 114480,114550,211980,601763,60727 ( 496)  391 90.0 1.5e-17
XP_005246942 (OMIM: 114480,114550,211980,601763,60 ( 523)  391 90.0 1.6e-17
NP_001073594 (OMIM: 114480,114550,211980,601763,60 ( 538)  391 90.0 1.6e-17
XP_016872253 (OMIM: 601761) PREDICTED: caspase-7 i ( 311)  321 75.5 2.2e-13
NP_001307840 (OMIM: 601761) caspase-7 isoform g [H ( 311)  321 75.5 2.2e-13
XP_006718080 (OMIM: 601761) PREDICTED: caspase-7 i ( 317)  321 75.5 2.2e-13
XP_011538562 (OMIM: 601761) PREDICTED: caspase-7 i ( 270)  320 75.2 2.2e-13
NP_001253987 (OMIM: 601761) caspase-7 isoform f [H ( 278)  320 75.2 2.3e-13
NP_001218 (OMIM: 601761) caspase-7 isoform alpha p ( 303)  320 75.2 2.5e-13
NP_203125 (OMIM: 601761) caspase-7 isoform alpha p ( 303)  320 75.2 2.5e-13
NP_001253985 (OMIM: 601761) caspase-7 isoform alph ( 303)  320 75.2 2.5e-13
XP_016872252 (OMIM: 601761) PREDICTED: caspase-7 i ( 322)  320 75.3 2.6e-13
NP_001253986 (OMIM: 601761) caspase-7 isoform e [H ( 388)  321 75.5 2.6e-13
NP_203124 (OMIM: 601761) caspase-7 isoform delta [ ( 336)  320 75.3 2.7e-13
NP_001217 (OMIM: 601532) caspase-6 isoform alpha p ( 293)  286 68.2 3.1e-11
NP_001193471 (OMIM: 601762,603909,605027,613659) c ( 478)  270 65.1 4.5e-10
NP_001221 (OMIM: 601762,603909,605027,613659) casp ( 479)  270 65.1 4.5e-10
XP_006712859 (OMIM: 601762,603909,605027,613659) P ( 272)  263 63.5 7.6e-10
XP_005246964 (OMIM: 601762,603909,605027,613659) P ( 521)  263 63.7 1.3e-09
NP_116756 (OMIM: 601762,603909,605027,613659) casp ( 521)  263 63.7 1.3e-09
NP_116759 (OMIM: 601762,603909,605027,613659) casp ( 522)  263 63.7 1.3e-09
NP_001193453 (OMIM: 601762,603909,605027,613659) c ( 455)  232 57.2 9.7e-08
XP_011526163 (OMIM: 605848,617320) PREDICTED: casp ( 230)  224 55.4 1.7e-07
NP_036246 (OMIM: 605848,617320) caspase-14 precurs ( 242)  216 53.8 5.6e-07
NP_150636 (OMIM: 147678) caspase-1 isoform delta [ ( 263)  212 53.0 1.1e-06
NP_001129581 (OMIM: 602665) caspase-5 isoform b pr ( 376)  203 51.2 5.2e-06


>>NP_001220 (OMIM: 602234) caspase-9 isoform alpha precu  (416 aa)
 initn: 2819 init1: 2819 opt: 2819  Z-score: 3136.5  bits: 589.3 E(87180): 5.9e-168
Smith-Waterman score: 2819; 100.0% identity (100.0% similar) in 416 aa overlap (1-416:1-416)

               10        20        30        40        50        60
pF1KE1 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE1 TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE1 ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE1 TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG
              310       320       330       340       350       360

              370       380       390       400       410      
pF1KE1 SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
              370       380       390       400       410      

>>XP_011540575 (OMIM: 602234) PREDICTED: caspase-9 isofo  (421 aa)
 initn: 2639 init1: 2639 opt: 2641  Z-score: 2938.5  bits: 552.7 E(87180): 6.3e-157
Smith-Waterman score: 2641; 97.3% identity (98.0% similar) in 402 aa overlap (1-402:1-402)

               10        20        30        40        50        60
pF1KE1 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE1 TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE1 ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE1 TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG
              310       320       330       340       350       360

              370       380       390       400       410          
pF1KE1 SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS    
       :::::::::::::::::::::::::::. :   ::  . . :                  
XP_011 SWYVETLDDIFEQWAHSEDLQSLLLRVSAAFLCKGEGRLLRGSVSSWGWGFGVSRAGPNQ
              370       380       390       400       410       420

XP_011 G
        

>>XP_005246071 (OMIM: 602234) PREDICTED: caspase-9 isofo  (333 aa)
 initn: 2267 init1: 2267 opt: 2267  Z-score: 2524.3  bits: 475.7 E(87180): 7.4e-134
Smith-Waterman score: 2267; 100.0% identity (100.0% similar) in 333 aa overlap (84-416:1-333)

            60        70        80        90       100       110   
pF1KE1 QARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRP
                                     ::::::::::::::::::::::::::::::
XP_005                               MLASFLRTNRQAAKLSKPTLENLTPVVLRP
                                             10        20        30

           120       130       140       150       160       170   
pF1KE1 EIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCR
               40        50        60        70        80        90

           180       190       200       210       220       230   
pF1KE1 ESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVV
              100       110       120       130       140       150

           240       250       260       270       280       290   
pF1KE1 ILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKD
              160       170       180       190       200       210

           300       310       320       330       340       350   
pF1KE1 HGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVS
              220       230       240       250       260       270

           360       370       380       390       400       410   
pF1KE1 WRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFF
              280       290       300       310       320       330

          
pF1KE1 KTS
       :::
XP_005 KTS
          

>>NP_127463 (OMIM: 602234) caspase-9 isoform 3 [Homo sap  (333 aa)
 initn: 2267 init1: 2267 opt: 2267  Z-score: 2524.3  bits: 475.7 E(87180): 7.4e-134
Smith-Waterman score: 2267; 100.0% identity (100.0% similar) in 333 aa overlap (84-416:1-333)

            60        70        80        90       100       110   
pF1KE1 QARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRP
                                     ::::::::::::::::::::::::::::::
NP_127                               MLASFLRTNRQAAKLSKPTLENLTPVVLRP
                                             10        20        30

           120       130       140       150       160       170   
pF1KE1 EIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 EIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCR
               40        50        60        70        80        90

           180       190       200       210       220       230   
pF1KE1 ESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 ESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVV
              100       110       120       130       140       150

           240       250       260       270       280       290   
pF1KE1 ILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 ILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKD
              160       170       180       190       200       210

           300       310       320       330       340       350   
pF1KE1 HGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 HGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVS
              220       230       240       250       260       270

           360       370       380       390       400       410   
pF1KE1 WRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 WRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFF
              280       290       300       310       320       330

          
pF1KE1 KTS
       :::
NP_127 KTS
          

>>NP_001264983 (OMIM: 602234) caspase-9 isoform beta [Ho  (266 aa)
 initn: 1774 init1: 918 opt: 918  Z-score: 1026.2  bits: 198.2 E(87180): 2.1e-50
Smith-Waterman score: 1478; 63.9% identity (63.9% similar) in 416 aa overlap (1-416:1-266)

               10        20        30        40        50        60
pF1KE1 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR
       :::::::::::::::::::                                         
NP_001 LRPETPRPVDIGSGGFGDV-----------------------------------------
              130                                                  

              190       200       210       220       230       240
pF1KE1 TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ
                                                                   
NP_001 ------------------------------------------------------------
                                                                   

              250       260       270       280       290       300
pF1KE1 ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS
                                                        :::::::::::
NP_001 -------------------------------------------------EQKDHGFEVAS
                                                      140       150

              310       320       330       340       350       360
pF1KE1 TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG
              160       170       180       190       200       210

              370       380       390       400       410      
pF1KE1 SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
              220       230       240       250       260      

>>NP_116764 (OMIM: 600639) caspase-2 isoform 1 prepropro  (452 aa)
 initn: 308 init1: 200 opt: 437  Z-score: 488.0  bits: 99.4 E(87180): 2e-20
Smith-Waterman score: 548; 31.3% identity (59.0% similar) in 422 aa overlap (1-410:32-430)

                                             10        20        30
pF1KE1                               MDEADRRLLRRCRLRLVEELQVDQLWDALL
                                     :    .. :.. :. :...: ...: . ::
NP_116 AAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHLL
              10        20        30        40        50        60 

               40         50        60        70        80         
pF1KE1 SRELFRPHMIEDIQ-RAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFL
        ....  .: : :: ..:: :   :  .:.  :  :: ::.  :   :..: :  : ..:
NP_116 EKDIITLEMRELIQAKVGSFS---QNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDML
              70        80           90       100       110        

      90       100             110        120       130        140 
pF1KE1 RTNRQAAKLSKPTLE---NLT---PVVLR-PEIRKPEVLRPETPRPVDIGSGGFG-DVGA
        :. .. .   : :    .:.   ::    :  .: ..    . . .:  .:    .:  
NP_116 LTTLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKP
      120       130       140       150       160       170        

               150       160       170       180       190         
pF1KE1 L--ESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHF
          :  . . .::: :. .: :  :...::.:  :. :. :.:...:   :   :. : .
NP_116 CTPEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGY
      180       190       200       210       220       230        

     200       210       220        230       240       250        
pF1KE1 MVEVKGDLTAKKMVLALLELAQQD-HGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPV
        :.:  : ::..:   : ..::   : . : :.:..:::: .       ::.::.::  .
NP_116 DVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVE-------GAIYGVDGKLL
      240       250       260       270       280              290 

      260       270       280       290       300       310        
pF1KE1 SVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATP
       ..... ..:....:::: .:::.:::::: :.. :.: .  . . .  ::: . : ::  
NP_116 QLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCE-ESDA--
             300       310       320       330       340           

      320       330       340       350       360       370        
pF1KE1 FQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSE
          : . . ..     ::: ::.. .:. . : .. :. : ::::.:.: ..: . : . 
NP_116 ---GKEKLPKM----RLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDM
         350           360       370       380       390       400 

      380       390       400       410                      
pF1KE1 DLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS                
        . ..:..: ::. .:      ::  .: : :                      
NP_116 HVADMLVKV-NAL-IKDREGYAPGT-EFHRCKEMSEYCSTLCRHLYLFPGHPPT
             410         420        430       440       450  

>>NP_001215 (OMIM: 600639) caspase-2 isoform 2 [Homo sap  (312 aa)
 initn: 170 init1: 170 opt: 402  Z-score: 451.5  bits: 92.1 E(87180): 2.1e-18
Smith-Waterman score: 402; 31.9% identity (59.5% similar) in 301 aa overlap (1-289:1-291)

               10        20        30        40         50         
pF1KE1 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQ-RAGSGSRRDQARQLI
       :    .. :.. :. :...: ...: . :: ....  .: : :: ..:: :   :  .:.
NP_001 MHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKVGSFS---QNVELL
               10        20        30        40        50          

      60        70        80        90       100             110   
pF1KE1 IDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLE---NLT---PVVLR-
         :  :: ::.  :   :..: :  : ..: :. .. .   : :    .:.   ::    
NP_001 NLLPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPPLSCDYDLSLPFPVCESC
        60        70        80        90       100       110       

            120       130        140         150       160         
pF1KE1 PEIRKPEVLRPETPRPVDIGSGGFG-DVGAL--ESLRGNADLAYILSMEPCGHCLIINNV
       :  .: ..    . . .:  .:    .:     :  . . .::: :. .: :  :...::
NP_001 PLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCTPEFYQTHFQLAYRLQSRPRGLALVLSNV
       120       130       140       150       160       170       

     170       180       190       200       210       220         
pF1KE1 NFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQD-HGALD
       .:  :. :. :.:...:   :   :. : . :.:  : ::..:   : ..::   : . :
NP_001 HFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTD
       180       190       200       210       220       230       

      230       240       250       260       270       280        
pF1KE1 CCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACG
        :.:..:::: .       ::.::.::  ...... ..:....:::: .:::.:::::: 
NP_001 SCIVALLSHGVE-------GAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACR
       240              250       260       270       280       290

      290       300       310       320       330       340        
pF1KE1 GEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTF
       :                                                           
NP_001 GGAIGSLGHLLLFTAATASLAL                                      
              300       310                                        

>>NP_116786 (OMIM: 600636) caspase-3 preproprotein [Homo  (277 aa)
 initn: 509 init1: 221 opt: 392  Z-score: 441.2  bits: 90.0 E(87180): 8e-18
Smith-Waterman score: 514; 33.2% identity (61.3% similar) in 274 aa overlap (150-413:34-275)

     120       130       140       150       160       170         
pF1KE1 VLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRT
                                     : .: ...   : :.:::: :: . .:. .
NP_116 TENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTS
            10        20        30        40        50        60   

     180       190       200       210       220       230         
pF1KE1 RTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGC
       :.:...:  .::. : .:.. :. :.::: ...:  . .....::.  .  : :.:::: 
NP_116 RSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGE
            70        80        90       100       110       120   

     240       250       260       270       280       290         
pF1KE1 QASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVA
       .       : ..::.: ::...::.:.: :  : :: ::::::.:::: : . : :.:. 
NP_116 E-------GIIFGTNG-PVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETD
                  130        140       150       160       170     

     300       310       320       330       340       350         
pF1KE1 STSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKS
       :   .:                         :  ..:. .:.. .::: ::. :::. :.
NP_116 SGVDDDM------------------------ACHKIPVEADFLYAYSTAPGYYSWRNSKD
         180                               190       200       210 

     360       370       380       390                 400         
pF1KE1 GSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVK----------GIYKQMPGCFNFLRK
       :::....:  ...:.: . ... .: ::   :...             ::.:   ..: :
NP_116 GSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTK
             220       230       240       250       260       270 

     410      
pF1KE1 KLFFKTS
       .:.:   
NP_116 ELYFYH 
              

>>NP_004337 (OMIM: 600636) caspase-3 preproprotein [Homo  (277 aa)
 initn: 509 init1: 221 opt: 392  Z-score: 441.2  bits: 90.0 E(87180): 8e-18
Smith-Waterman score: 514; 33.2% identity (61.3% similar) in 274 aa overlap (150-413:34-275)

     120       130       140       150       160       170         
pF1KE1 VLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRT
                                     : .: ...   : :.:::: :: . .:. .
NP_004 TENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTS
            10        20        30        40        50        60   

     180       190       200       210       220       230         
pF1KE1 RTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGC
       :.:...:  .::. : .:.. :. :.::: ...:  . .....::.  .  : :.:::: 
NP_004 RSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGE
            70        80        90       100       110       120   

     240       250       260       270       280       290         
pF1KE1 QASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVA
       .       : ..::.: ::...::.:.: :  : :: ::::::.:::: : . : :.:. 
NP_004 E-------GIIFGTNG-PVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETD
                  130        140       150       160       170     

     300       310       320       330       340       350         
pF1KE1 STSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKS
       :   .:                         :  ..:. .:.. .::: ::. :::. :.
NP_004 SGVDDDM------------------------ACHKIPVEADFLYAYSTAPGYYSWRNSKD
         180                               190       200       210 

     360       370       380       390                 400         
pF1KE1 GSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVK----------GIYKQMPGCFNFLRK
       :::....:  ...:.: . ... .: ::   :...             ::.:   ..: :
NP_004 GSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTK
             220       230       240       250       260       270 

     410      
pF1KE1 KLFFKTS
       .:.:   
NP_004 ELYFYH 
              

>>XP_011530603 (OMIM: 600636) PREDICTED: caspase-3 isofo  (277 aa)
 initn: 509 init1: 221 opt: 392  Z-score: 441.2  bits: 90.0 E(87180): 8e-18
Smith-Waterman score: 514; 33.2% identity (61.3% similar) in 274 aa overlap (150-413:34-275)

     120       130       140       150       160       170         
pF1KE1 VLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRT
                                     : .: ...   : :.:::: :: . .:. .
XP_011 TENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTS
            10        20        30        40        50        60   

     180       190       200       210       220       230         
pF1KE1 RTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGC
       :.:...:  .::. : .:.. :. :.::: ...:  . .....::.  .  : :.:::: 
XP_011 RSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGE
            70        80        90       100       110       120   

     240       250       260       270       280       290         
pF1KE1 QASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVA
       .       : ..::.: ::...::.:.: :  : :: ::::::.:::: : . : :.:. 
XP_011 E-------GIIFGTNG-PVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETD
                  130        140       150       160       170     

     300       310       320       330       340       350         
pF1KE1 STSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKS
       :   .:                         :  ..:. .:.. .::: ::. :::. :.
XP_011 SGVDDDM------------------------ACHKIPVEADFLYAYSTAPGYYSWRNSKD
         180                               190       200       210 

     360       370       380       390                 400         
pF1KE1 GSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVK----------GIYKQMPGCFNFLRK
       :::....:  ...:.: . ... .: ::   :...             ::.:   ..: :
XP_011 GSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTK
             220       230       240       250       260       270 

     410      
pF1KE1 KLFFKTS
       .:.:   
XP_011 ELYFYH 
              




416 residues in 1 query   sequences
61989856 residues in 87180 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Mon May 22 10:33:29 2017 done: Mon May 22 10:33:30 2017
 Total Scan time:  9.360 Total Display time:  0.050

Function used was FASTA [36.3.4 Apr, 2011]
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