Result of FASTA (omim) for pF1KB5749
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB5749, 808 aa
  1>>>pF1KB5749 808 - 808 aa - 808 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 9.1419+/-0.000524; mu= 2.8463+/- 0.033
 mean_var=215.2204+/-43.456, 0's: 0 Z-trim(114.2): 41  B-trim: 0 in 0/53
 Lambda= 0.087424
 statistics sampled from 23916 (23945) to 23916 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.618), E-opt: 0.2 (0.281), width:  16
 Scan time: 13.300

The best scores are:                                      opt bits E(85289)
NP_002379 (OMIM: 602693) DNA replication licensing ( 853) 5211 671.2 5.3e-192
NP_001257401 (OMIM: 602693) DNA replication licens ( 818) 4808 620.3  1e-176
NP_004517 (OMIM: 116945,616968) DNA replication li ( 904) 1064 148.1 1.6e-34
NP_005907 (OMIM: 600592) DNA replication licensing ( 719) 1020 142.5 6.2e-33
XP_005250405 (OMIM: 600592) PREDICTED: DNA replica ( 612) 1011 141.3 1.2e-32
XP_016867706 (OMIM: 600592) PREDICTED: DNA replica ( 612) 1011 141.3 1.2e-32
NP_877577 (OMIM: 600592) DNA replication licensing ( 543)  949 133.5 2.5e-30
NP_001265524 (OMIM: 600592) DNA replication licens ( 543)  949 133.5 2.5e-30
XP_006724305 (OMIM: 602696) PREDICTED: DNA replica ( 732)  856 121.8 1.1e-26
NP_006730 (OMIM: 602696) DNA replication licensing ( 734)  856 121.8 1.1e-26
NP_060166 (OMIM: 610098,616185) DNA helicase MCM9  (1143)  768 110.9 3.3e-23
NP_877423 (OMIM: 602638,609981) DNA replication li ( 863)  752 108.8 1.1e-22
NP_005905 (OMIM: 602638,609981) DNA replication li ( 863)  752 108.8 1.1e-22
NP_005906 (OMIM: 223100,601806) DNA replication li ( 821)  750 108.5 1.2e-22
NP_877954 (OMIM: 608187,612885) DNA helicase MCM8  ( 824)  704 102.7 6.9e-21
XP_016883596 (OMIM: 608187,612885) PREDICTED: DNA  ( 557)  588 88.0 1.3e-16
XP_016883595 (OMIM: 608187,612885) PREDICTED: DNA  ( 776)  588 88.1 1.7e-16
NP_001268449 (OMIM: 608187,612885) DNA helicase MC ( 840)  588 88.1 1.8e-16
NP_115874 (OMIM: 608187,612885) DNA helicase MCM8  ( 840)  588 88.1 1.8e-16
XP_016883594 (OMIM: 608187,612885) PREDICTED: DNA  ( 880)  525 80.1 4.5e-14
NP_001268450 (OMIM: 608187,612885) DNA helicase MC ( 880)  525 80.1 4.5e-14
XP_011527689 (OMIM: 608187,612885) PREDICTED: DNA  ( 581)  486 75.1 9.8e-13
NP_001268451 (OMIM: 608187,612885) DNA helicase MC ( 793)  420 66.9   4e-10
NP_694987 (OMIM: 610098,616185) DNA helicase MCM9  ( 391)  363 59.5 3.4e-08


>>NP_002379 (OMIM: 602693) DNA replication licensing fac  (853 aa)
 initn: 5211 init1: 5211 opt: 5211  Z-score: 3568.0  bits: 671.2 E(85289): 5.3e-192
Smith-Waterman score: 5211; 100.0% identity (100.0% similar) in 808 aa overlap (1-808:46-853)

                                             10        20        30
pF1KB5                               MAGTVVLDDVELREAQRDYLDFLDDEEDQG
                                     ::::::::::::::::::::::::::::::
NP_002 REEFGSFRAGVESSWEPPRDFGGGSSLAAGMAGTVVLDDVELREAQRDYLDFLDDEEDQG
          20        30        40        50        60        70     

               40        50        60        70        80        90
pF1KB5 IYQSKVRELISDNQYRLIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIDAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IYQSKVRELISDNQYRLIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIDAT
          80        90       100       110       120       130     

              100       110       120       130       140       150
pF1KB5 YAKQYEEFYVGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 YAKQYEEFYVGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPA
         140       150       160       170       180       190     

              160       170       180       190       200       210
pF1KB5 TKKTIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYKDHQTITIQEMPEKAPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TKKTIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYKDHQTITIQEMPEKAPA
         200       210       220       230       240       250     

              220       230       240       250       260       270
pF1KB5 GQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPGKKGGYTSGTFRTVLIACNVKQMSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPGKKGGYTSGTFRTVLIACNVKQMSK
         260       270       280       290       300       310     

              280       290       300       310       320       330
pF1KB5 DAQPSFSAEDIAKIKKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DAQPSFSAEDIAKIKKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLE
         320       330       340       350       360       370     

              340       350       360       370       380       390
pF1KB5 NGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGE
         380       390       400       410       420       430     

              400       410       420       430       440       450
pF1KB5 RRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLA
         440       450       460       470       480       490     

              460       470       480       490       500       510
pF1KB5 AANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAP
         500       510       520       530       540       550     

              520       530       540       550       560       570
pF1KB5 GEQDGDAMPLGSAVDILATDDPNFSQEDQQDTQIYEKHDNLLHGTKKKKEKMVSAAFMKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GEQDGDAMPLGSAVDILATDDPNFSQEDQQDTQIYEKHDNLLHGTKKKKEKMVSAAFMKK
         560       570       580       590       600       610     

              580       590       600       610       620       630
pF1KB5 YIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 YIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAK
         620       630       640       650       660       670     

              640       650       660       670       680       690
pF1KB5 ARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSEDESETEDEEEKSQEDQEQKRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSEDESETEDEEEKSQEDQEQKRK
         680       690       700       710       720       730     

              700       710       720       730       740       750
pF1KB5 RRKTRQPDAKDGDSYDPYDFSDTEEEMPQVHTPKTADSQETKESQKVELSESRLKAFKVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RRKTRQPDAKDGDSYDPYDFSDTEEEMPQVHTPKTADSQETKESQKVELSESRLKAFKVA
         740       750       760       770       780       790     

              760       770       780       790       800        
pF1KB5 LLDVFREAHAQSIGMNRLTESINRDSEEPFSSVEIQAALSKMQDDNQVMVSEGIIFLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LLDVFREAHAQSIGMNRLTESINRDSEEPFSSVEIQAALSKMQDDNQVMVSEGIIFLI
         800       810       820       830       840       850   

>>NP_001257401 (OMIM: 602693) DNA replication licensing   (818 aa)
 initn: 4808 init1: 4808 opt: 4808  Z-score: 3293.5  bits: 620.3 E(85289): 1e-176
Smith-Waterman score: 4808; 100.0% identity (100.0% similar) in 745 aa overlap (64-808:74-818)

            40        50        60        70        80        90   
pF1KB5 SKVRELISDNQYRLIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIDATYAK
                                     ::::::::::::::::::::::::::::::
NP_001 LWQRAWRVPWCWTMWSCGRLREITWTSWTTRLLNNAFEELVAFQRALKDFVASIDATYAK
            50        60        70        80        90       100   

           100       110       120       130       140       150   
pF1KB5 QYEEFYVGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QYEEFYVGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKK
           110       120       130       140       150       160   

           160       170       180       190       200       210   
pF1KB5 TIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQL
           170       180       190       200       210       220   

           220       230       240       250       260       270   
pF1KB5 PRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPGKKGGYTSGTFRTVLIACNVKQMSKDAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPGKKGGYTSGTFRTVLIACNVKQMSKDAQ
           230       240       250       260       270       280   

           280       290       300       310       320       330   
pF1KB5 PSFSAEDIAKIKKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSFSAEDIAKIKKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGS
           290       300       310       320       330       340   

           340       350       360       370       380       390   
pF1KB5 HIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRL
           350       360       370       380       390       400   

           400       410       420       430       440       450   
pF1KB5 EAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAAN
           410       420       430       440       450       460   

           460       470       480       490       500       510   
pF1KB5 PVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQ
           470       480       490       500       510       520   

           520       530       540       550       560       570   
pF1KB5 DGDAMPLGSAVDILATDDPNFSQEDQQDTQIYEKHDNLLHGTKKKKEKMVSAAFMKKYIH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGDAMPLGSAVDILATDDPNFSQEDQQDTQIYEKHDNLLHGTKKKKEKMVSAAFMKKYIH
           530       540       550       560       570       580   

           580       590       600       610       620       630   
pF1KB5 VAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAKARM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAKARM
           590       600       610       620       630       640   

           640       650       660       670       680       690   
pF1KB5 SKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSEDESETEDEEEKSQEDQEQKRKRRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSEDESETEDEEEKSQEDQEQKRKRRK
           650       660       670       680       690       700   

           700       710       720       730       740       750   
pF1KB5 TRQPDAKDGDSYDPYDFSDTEEEMPQVHTPKTADSQETKESQKVELSESRLKAFKVALLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TRQPDAKDGDSYDPYDFSDTEEEMPQVHTPKTADSQETKESQKVELSESRLKAFKVALLD
           710       720       730       740       750       760   

           760       770       780       790       800        
pF1KB5 VFREAHAQSIGMNRLTESINRDSEEPFSSVEIQAALSKMQDDNQVMVSEGIIFLI
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFREAHAQSIGMNRLTESINRDSEEPFSSVEIQAALSKMQDDNQVMVSEGIIFLI
           770       780       790       800       810        

>>NP_004517 (OMIM: 116945,616968) DNA replication licens  (904 aa)
 initn: 872 init1: 699 opt: 1064  Z-score: 740.8  bits: 148.1 E(85289): 1.6e-34
Smith-Waterman score: 1104; 33.4% identity (64.0% similar) in 677 aa overlap (10-679:193-830)

                                    10        20        30         
pF1KB5                      MAGTVVLDDVELREAQRDYLDFLDDEEDQGIYQSKVREL
                                     .:...  ...:    : . ..... .. ..
NP_004 EDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDM
            170       180       190       200       210       220  

      40        50        60        70        80        90         
pF1KB5 ISDNQYRLIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFY
        ..:.  :.:: .::  ...  :  : .   : :  :..:  . : ..   : .  ....
NP_004 CKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIH
            230       240       250       260       270       280  

     100       110       120       130       140       150         
pF1KB5 VGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRY
       : .      ...  :.: .  :. .. . :.::.:. : :..    . :   . ..    
NP_004 VRISHLPLVEEL--RSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVLGPFC
            290         300       310       320       330       340

     160       170       180       190       200       210         
pF1KB5 SDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDV
       .. .  :  :.:   : . .  .:.:...  ..:...: : ::: : :. ::.:::: :.
NP_004 QSQNQEVK-PGSC--P-ECQSAGPFEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDA
               350          360       370       380       390      

     220       230       240       250         260        270      
pF1KB5 ILDDDLVDKAKPGDRVQVVGTYRCLPGKKGGYTSG--TFRTVLIACNV-KQMSKDAQPSF
       ::  ::::. ::::.....: :.     . . ..:  .: ::..: .: :. .: :   .
NP_004 ILLADLVDSCKPGDEIELTGIYHNNYDGSLNTANGFPVFATVILANHVAKKDNKVAVGEL
        400       410       420       430       440       450      

        280       290       300       310       320       330      
pF1KB5 SAEDIAKIKKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSH-I
       . ::.  : ..::  ...: ...  :.::::.::. .:...   :.::  ..  .:.: .
NP_004 TDEDVKMITSLSK--DQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKN-PGGKHKV
        460         470       480       490       500        510   

         340       350       360       370       380       390     
pF1KB5 RGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEA
       :::::.:: :::..::::.:.:.  .. ::: :::.:.:.::::: :     . :  :::
NP_004 RGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEA
           520       530       540       550       560       570   

         400       410       420       430       440       450     
pF1KB5 GAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPV
       ::.:::::::  :::::::.:.:::.:::.:::  ..:.:::: . :.:::.:.:::::.
NP_004 GALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPI
           580       590       600       610       620       630   

         460       470       480       490       500       510     
pF1KB5 YGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQDG
        ::::   :  ::. : . ..::::.: .. : .:: ::. ..  :.  :  . :.... 
NP_004 GGRYDPSLTFSENVDLTEPIISRFDILCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEE
           640       650       660       670       680       690   

         520       530       540       550       560       570     
pF1KB5 DAMPLGSAVDILATDDPNFSQEDQQDTQIYEKHDNLLHGTKKKKEKMVSAAFMKKYIHVA
       ...  :::..      ::                   .:..   ...     .::::  :
NP_004 EGLANGSAAEPAM---PN------------------TYGVEPLPQEV-----LKKYIIYA
           700                            710            720       

          580       590       600       610       620       630    
pF1KB5 KI-IKPVLTQESATYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAKARMS
       :  ..: :.: .   .:. :: :: ..::.. .    :.:.: .:..::.: :::. .. 
NP_004 KERVHPKLNQMDQDKVAKMYSDLR-KESMATGSI---PITVRHIESMIRMAEAHARIHLR
       730       740       750        760          770       780   

          640       650         660       670       680       690  
pF1KB5 KTVDLQDAEEAVELVQYAYF--KKVLEKEKKRKKRSEDESETEDEEEKSQEDQEQKRKRR
         :  .:.. :....  ...  .:    .. ::  ..  :  .:..:             
NP_004 DYVIEDDVNMAIRVMLESFIDTQKFSVMRSMRKTFARYLSFRRDNNELLLFILKQLVAEQ
           790       800       810       820       830       840   

            700       710       720       730       740       750  
pF1KB5 KTRQPDAKDGDSYDPYDFSDTEEEMPQVHTPKTADSQETKESQKVELSESRLKAFKVALL
                                                                   
NP_004 VTYQRNRFGAQQDTIEVPEKDLVDKARQINIHNLSAFYDSELFRMNKFSHDLKRKMILQQ
           850       860       870       880       890       900   

>>NP_005907 (OMIM: 600592) DNA replication licensing fac  (719 aa)
 initn: 866 init1: 780 opt: 1020  Z-score: 712.3  bits: 142.5 E(85289): 6.2e-33
Smith-Waterman score: 1093; 35.4% identity (62.1% similar) in 676 aa overlap (5-669:50-655)

                                         10        20          30  
pF1KB5                           MAGTVVLDDVELREAQRDYLDFLDDEEDQ--GIY
                                     : ::::   : . . .: . ..  .   ..
NP_005 FYQDDELGKKQFKYGNQLVRLAHREQVALYVDLDDVA--EDDPELVDSICENARRYAKLF
      20        30        40        50          60        70       

             40        50        60        70        80          90
pF1KB5 QSKVRELISDNQYRLIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKD--FVASIDAT
        . :.::. . . : .:: . :    :.:           :.  ::. .:  .: : .  
NP_005 ADAVQELLPQYKEREVVNKDVLDVYIEHR-----------LMMEQRS-RDPGMVRSPQNQ
        80        90       100                  110        120     

               100       110       120       130       140         
pF1KB5 Y-AKQYEEFYVGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCP
       : :. ...: . ..:  ..:    : . .  .. .: :.::::. : :.::.: ... : 
NP_005 YPAELMRRFELYFQGPSSNKPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCD
         130       140       150       160       170       180     

     150        160        170       180       190       200       
pF1KB5 AT-KKTIERRYSD-LTTLVAFPSSSVYPTKDEENNPLETEYGLSVYKDHQTITIQEMPEK
           .: .   :  .  :.  ::.    ...     :.:. : : .   : . .::  ..
NP_005 QCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTR-G-SRFIKFQEMKMQEHSDQ
         190       200       210       220         230       240   

       210       220       230       240       250           260   
pF1KB5 APAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPGKKGGY---TSGTF-RTVLIAC
       .:.:..:::. :... . .  :.:::.:.:.: .  ::  . :.   ..: . .: : : 
NP_005 VPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIF--LPILRTGFRQVVQGLLSETYLEAH
           250       260       270         280       290       300 

           270       280       290       300       310       320   
pF1KB5 NVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLG
        . .:.:. .   .: .... ... .   .:....:: :.:: :.::. ::::.: ::.:
NP_005 RIVKMNKSEDDESGAGELTR-EELRQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVG
             310       320        330       340       350       360

           330       340       350       360       370       380   
pF1KB5 GVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVT
       ::...   : .:::.::: :.:::.::::::: :.   :::.  ::::::::::::::: 
NP_005 GVDQS-PRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVL
               370       380       390       400       410         

           390       400       410       420       430       440   
pF1KB5 TDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLN
        :. .::  ::.::.::::.:: ::::::::.. :::::::::::  ..:::::: . ::
NP_005 RDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLN
     420       430       440       450       460       470         

           450       460       470       480       490       500   
pF1KB5 ARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLR
       ::::.::::::.::::.  ..  .:: :  .::::::::... :. : ..: ....:.  
NP_005 ARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITY
     480       490       500       510       520       530         

           510       520       530       540       550       560   
pF1KB5 MHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQEDQQDTQIYEKHDNLLHGTKKKKEKMV
       .:                              :...:  . .:  :  :           
NP_005 VH------------------------------QHSRQPPSQFEPLDMKL-----------
     540                                     550                   

           570       580       590       600       610       620   
pF1KB5 SAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIR
           :..:: . .  .:.. .  : ::.  : ..: .   :.:.. ::   :::: ...:
NP_005 ----MRRYIAMCREKQPMVPESLADYITAAYVEMRREAWASKDATYTS---ARTLLAILR
          560       570       580       590       600          610 

           630       640       650       660       670       680   
pF1KB5 LATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSEDESETEDEEEKSQE
       :.:: :. ::  .:. .:..::..:....  :  :  .: .  :..              
NP_005 LSTALARLRMVDVVEKEDVNEAIRLMEMS--KDSLLGDKGQTARTQRPADVIFATVRELV
             620       630       640         650       660         

           690       700       710       720       730       740   
pF1KB5 DQEQKRKRRKTRQPDAKDGDSYDPYDFSDTEEEMPQVHTPKTADSQETKESQKVELSESR
                                                                   
NP_005 SGGRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNASRTRITFV          
     670       680       690       700       710                   

>>XP_005250405 (OMIM: 600592) PREDICTED: DNA replication  (612 aa)
 initn: 866 init1: 780 opt: 1011  Z-score: 707.1  bits: 141.3 E(85289): 1.2e-32
Smith-Waterman score: 1079; 37.1% identity (64.3% similar) in 585 aa overlap (92-669:21-548)

              70        80        90       100       110       120 
pF1KB5 ANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYVGLEGSFGSKHVSPRTLTSCFL
                                     :. ...: . ..:  ..:    : . .  .
XP_005           MMEQRSRDPGMVRSPQNQYPAELMRRFELYFQGPSSNKPRVIREVRADSV
                         10        20        30        40        50

             130       140       150        160        170         
pF1KB5 SCVVCVEGIVTKCSLVRPKVVRSVHYCPAT-KKTIERRYSD-LTTLVAFPSSSVYPTKDE
       . .: :.::::. : :.::.: ... :     .: .   :  .  :.  ::.    ... 
XP_005 GKLVTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSG
               60        70        80        90       100       110

     180       190       200       210       220       230         
pF1KB5 ENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVG
           :.:. : : .   : . .::  ...:.:..:::. :... . .  :.:::.:.:.:
XP_005 GRLYLQTR-G-SRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTG
                120       130       140       150       160        

     240       250           260       270       280       290     
pF1KB5 TYRCLPGKKGGY---TSGTF-RTVLIACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDI
        .  ::  . :.   ..: . .: : :  . .:.:. .   .: .... ... .   .:.
XP_005 IF--LPILRTGFRQVVQGLLSETYLEAHRIVKMNKSEDDESGAGELTR-EELRQIAEEDF
      170         180       190       200       210        220     

         300       310       320       330       340       350     
pF1KB5 FDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLL
       ...:: :.:: :.::. ::::.: ::.:::...   : .:::.::: :.:::.:::::::
XP_005 YEKLAASIAPEIYGHEDVKKALLLLLVGGVDQS-PRGMKIRGNINICLMGDPGVAKSQLL
         230       240       250        260       270       280    

         360       370       380       390       400       410     
pF1KB5 RYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMS
        :.   :::.  :::::::::::::::  :. .::  ::.::.::::.:: ::::::::.
XP_005 SYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMA
          290       300       310       320       330       340    

         420       430       440       450       460       470     
pF1KB5 DMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSL
       . :::::::::::  ..:::::: . ::::::.::::::.::::.  ..  .:: :  .:
XP_005 EADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAAL
          350       360       370       380       390       400    

         480       490       500        510       520       530    
pF1KB5 LSRFDLLFIMLDQMDPEQDREISDHVLRMHRY-RAPGEQDGDAMPLGSAVDILATDDPNF
       :::::::... :. : ..: ....:.  .:.. : :        :               
XP_005 LSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQP--------P---------------
          410       420       430       440                        

          540       550       560       570       580       590    
pF1KB5 SQEDQQDTQIYEKHDNLLHGTKKKKEKMVSAAFMKKYIHVAKIIKPVLTQESATYIAEEY
       :: .  : ..                       :..:: . .  .:.. .  : ::.  :
XP_005 SQFEPLDMKL-----------------------MRRYIAMCREKQPMVPESLADYITAAY
             450                              460       470        

          600       610       620       630       640       650    
pF1KB5 SRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYF
        ..: .   :.:.. ::   :::: ...::.:: :. ::  .:. .:..::..:....  
XP_005 VEMRREAWASKDATYTS---ARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMS--
      480       490          500       510       520       530     

          660       670       680       690       700       710    
pF1KB5 KKVLEKEKKRKKRSEDESETEDEEEKSQEDQEQKRKRRKTRQPDAKDGDSYDPYDFSDTE
       :  :  .: .  :..                                             
XP_005 KDSLLGDKGQTARTQRPADVIFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDE
           540       550       560       570       580       590   

>>XP_016867706 (OMIM: 600592) PREDICTED: DNA replication  (612 aa)
 initn: 866 init1: 780 opt: 1011  Z-score: 707.1  bits: 141.3 E(85289): 1.2e-32
Smith-Waterman score: 1079; 37.1% identity (64.3% similar) in 585 aa overlap (92-669:21-548)

              70        80        90       100       110       120 
pF1KB5 ANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYVGLEGSFGSKHVSPRTLTSCFL
                                     :. ...: . ..:  ..:    : . .  .
XP_016           MMEQRSRDPGMVRSPQNQYPAELMRRFELYFQGPSSNKPRVIREVRADSV
                         10        20        30        40        50

             130       140       150        160        170         
pF1KB5 SCVVCVEGIVTKCSLVRPKVVRSVHYCPAT-KKTIERRYSD-LTTLVAFPSSSVYPTKDE
       . .: :.::::. : :.::.: ... :     .: .   :  .  :.  ::.    ... 
XP_016 GKLVTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSG
               60        70        80        90       100       110

     180       190       200       210       220       230         
pF1KB5 ENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVG
           :.:. : : .   : . .::  ...:.:..:::. :... . .  :.:::.:.:.:
XP_016 GRLYLQTR-G-SRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTG
                120       130       140       150       160        

     240       250           260       270       280       290     
pF1KB5 TYRCLPGKKGGY---TSGTF-RTVLIACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDI
        .  ::  . :.   ..: . .: : :  . .:.:. .   .: .... ... .   .:.
XP_016 IF--LPILRTGFRQVVQGLLSETYLEAHRIVKMNKSEDDESGAGELTR-EELRQIAEEDF
      170         180       190       200       210        220     

         300       310       320       330       340       350     
pF1KB5 FDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLL
       ...:: :.:: :.::. ::::.: ::.:::...   : .:::.::: :.:::.:::::::
XP_016 YEKLAASIAPEIYGHEDVKKALLLLLVGGVDQS-PRGMKIRGNINICLMGDPGVAKSQLL
         230       240       250        260       270       280    

         360       370       380       390       400       410     
pF1KB5 RYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMS
        :.   :::.  :::::::::::::::  :. .::  ::.::.::::.:: ::::::::.
XP_016 SYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMA
          290       300       310       320       330       340    

         420       430       440       450       460       470     
pF1KB5 DMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSL
       . :::::::::::  ..:::::: . ::::::.::::::.::::.  ..  .:: :  .:
XP_016 EADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAAL
          350       360       370       380       390       400    

         480       490       500        510       520       530    
pF1KB5 LSRFDLLFIMLDQMDPEQDREISDHVLRMHRY-RAPGEQDGDAMPLGSAVDILATDDPNF
       :::::::... :. : ..: ....:.  .:.. : :        :               
XP_016 LSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQP--------P---------------
          410       420       430       440                        

          540       550       560       570       580       590    
pF1KB5 SQEDQQDTQIYEKHDNLLHGTKKKKEKMVSAAFMKKYIHVAKIIKPVLTQESATYIAEEY
       :: .  : ..                       :..:: . .  .:.. .  : ::.  :
XP_016 SQFEPLDMKL-----------------------MRRYIAMCREKQPMVPESLADYITAAY
             450                              460       470        

          600       610       620       630       640       650    
pF1KB5 SRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYF
        ..: .   :.:.. ::   :::: ...::.:: :. ::  .:. .:..::..:....  
XP_016 VEMRREAWASKDATYTS---ARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMS--
      480       490          500       510       520       530     

          660       670       680       690       700       710    
pF1KB5 KKVLEKEKKRKKRSEDESETEDEEEKSQEDQEQKRKRRKTRQPDAKDGDSYDPYDFSDTE
       :  :  .: .  :..                                             
XP_016 KDSLLGDKGQTARTQRPADVIFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDE
           540       550       560       570       580       590   

>>NP_877577 (OMIM: 600592) DNA replication licensing fac  (543 aa)
 initn: 821 init1: 735 opt: 949  Z-score: 665.6  bits: 133.5 E(85289): 2.5e-30
Smith-Waterman score: 1017; 38.7% identity (65.2% similar) in 509 aa overlap (165-669:27-479)

          140       150       160       170       180       190    
pF1KB5 SLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYK
                                     :.  ::.    ...     :.:. : : . 
NP_877     MVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTR-G-SRFI
                   10        20        30        40         50     

          200       210       220       230       240       250    
pF1KB5 DHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPGKKGGY---
         : . .::  ...:.:..:::. :... . .  :.:::.:.:.: .  ::  . :.   
NP_877 KFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIF--LPILRTGFRQV
           60        70        80        90       100         110  

              260       270       280       290       300       310
pF1KB5 TSGTF-RTVLIACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDIFDQLAKSLAPSIHGH
       ..: . .: : :  . .:.:. .   .: .... ... .   .:....:: :.:: :.::
NP_877 VQGLLSETYLEAHRIVKMNKSEDDESGAGELTR-EELRQIAEEDFYEKLAASIAPEIYGH
            120       130       140        150       160       170 

              320       330       340       350       360       370
pF1KB5 DYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTG
       . ::::.: ::.:::...   : .:::.::: :.:::.::::::: :.   :::.  :::
NP_877 EDVKKALLLLLVGGVDQS-PRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTG
             180        190       200       210       220       230

              380       390       400       410       420       430
pF1KB5 RGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGR
       ::::::::::::  :. .::  ::.::.::::.:: ::::::::.. :::::::::::  
NP_877 RGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQT
              240       250       260       270       280       290

              440       450       460       470       480       490
pF1KB5 VTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMD
       ..:::::: . ::::::.::::::.::::.  ..  .:: :  .::::::::... :. :
NP_877 ISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPD
              300       310       320       330       340       350

              500       510       520       530       540       550
pF1KB5 PEQDREISDHVLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQEDQQDTQIYEKHDN
        ..: ....:.  .:                              :...:  . .:  : 
NP_877 RDNDLRLAQHITYVH------------------------------QHSRQPPSQFEPLDM
              360                                     370       380

              560       570       580       590       600       610
pF1KB5 LLHGTKKKKEKMVSAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTART
        :               :..:: . .  .:.. .  : ::.  : ..: .   :.:.. :
NP_877 KL---------------MRRYIAMCREKQPMVPESLADYITAAYVEMRREAWASKDATYT
                             390       400       410       420     

              620       630       640       650       660       670
pF1KB5 SPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSED
       :   :::: ...::.:: :. ::  .:. .:..::..:....  :  :  .: .  :.. 
NP_877 S---ARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMS--KDSLLGDKGQTARTQR
            430       440       450       460         470       480

              680       690       700       710       720       730
pF1KB5 ESETEDEEEKSQEDQEQKRKRRKTRQPDAKDGDSYDPYDFSDTEEEMPQVHTPKTADSQE
                                                                   
NP_877 PADVIFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNASRTRI
              490       500       510       520       530       540

>>NP_001265524 (OMIM: 600592) DNA replication licensing   (543 aa)
 initn: 821 init1: 735 opt: 949  Z-score: 665.6  bits: 133.5 E(85289): 2.5e-30
Smith-Waterman score: 1017; 38.7% identity (65.2% similar) in 509 aa overlap (165-669:27-479)

          140       150       160       170       180       190    
pF1KB5 SLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYK
                                     :.  ::.    ...     :.:. : : . 
NP_001     MVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTR-G-SRFI
                   10        20        30        40         50     

          200       210       220       230       240       250    
pF1KB5 DHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPGKKGGY---
         : . .::  ...:.:..:::. :... . .  :.:::.:.:.: .  ::  . :.   
NP_001 KFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIF--LPILRTGFRQV
           60        70        80        90       100         110  

              260       270       280       290       300       310
pF1KB5 TSGTF-RTVLIACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDIFDQLAKSLAPSIHGH
       ..: . .: : :  . .:.:. .   .: .... ... .   .:....:: :.:: :.::
NP_001 VQGLLSETYLEAHRIVKMNKSEDDESGAGELTR-EELRQIAEEDFYEKLAASIAPEIYGH
            120       130       140        150       160       170 

              320       330       340       350       360       370
pF1KB5 DYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTG
       . ::::.: ::.:::...   : .:::.::: :.:::.::::::: :.   :::.  :::
NP_001 EDVKKALLLLLVGGVDQS-PRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTG
             180        190       200       210       220       230

              380       390       400       410       420       430
pF1KB5 RGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGR
       ::::::::::::  :. .::  ::.::.::::.:: ::::::::.. :::::::::::  
NP_001 RGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQT
              240       250       260       270       280       290

              440       450       460       470       480       490
pF1KB5 VTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMD
       ..:::::: . ::::::.::::::.::::.  ..  .:: :  .::::::::... :. :
NP_001 ISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPD
              300       310       320       330       340       350

              500       510       520       530       540       550
pF1KB5 PEQDREISDHVLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQEDQQDTQIYEKHDN
        ..: ....:.  .:                              :...:  . .:  : 
NP_001 RDNDLRLAQHITYVH------------------------------QHSRQPPSQFEPLDM
              360                                     370       380

              560       570       580       590       600       610
pF1KB5 LLHGTKKKKEKMVSAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTART
        :               :..:: . .  .:.. .  : ::.  : ..: .   :.:.. :
NP_001 KL---------------MRRYIAMCREKQPMVPESLADYITAAYVEMRREAWASKDATYT
                             390       400       410       420     

              620       630       640       650       660       670
pF1KB5 SPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSED
       :   :::: ...::.:: :. ::  .:. .:..::..:....  :  :  .: .  :.. 
NP_001 S---ARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMS--KDSLLGDKGQTARTQR
            430       440       450       460         470       480

              680       690       700       710       720       730
pF1KB5 ESETEDEEEKSQEDQEQKRKRRKTRQPDAKDGDSYDPYDFSDTEEEMPQVHTPKTADSQE
                                                                   
NP_001 PADVIFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNASRTRI
              490       500       510       520       530       540

>>XP_006724305 (OMIM: 602696) PREDICTED: DNA replication  (732 aa)
 initn: 868 init1: 625 opt: 856  Z-score: 600.4  bits: 121.8 E(85289): 1.1e-26
Smith-Waterman score: 995; 31.3% identity (58.1% similar) in 718 aa overlap (3-690:17-682)

                             10          20           30        40 
pF1KB5               MAGTVVLDDVELREAQ--RDYLDFLDDEE---DQGIYQSKVRELIS
                       : .  :. . :..:  : . .:: . .   :.  .  : :. ..
XP_006 MSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELK
               10        20        30        40        50        60

                  50        60        70        80           90    
pF1KB5 DN----QYRLIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALK---DFVASIDATYAKQ
        .    .: . :...::   .:  :. : ..  :.:  ...: :   : :.    .  . 
XP_006 RHYNLGEYWIEVEMEDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEV
               70        80        90       100       110       120

          100       110       120       130       140       150    
pF1KB5 YEEFYVGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKT
        ... : :...  ..  : :.: : ..: .: . ::.   : :: :..:    : . ..:
XP_006 LQDIQVMLKSD--ASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNT
              130         140       150       160       170        

           160       170       180       190          200       210
pF1KB5 IER-RYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYK---DHQTITIQEMPEKAPA
       .    .       :.: .       . . ::.  . .       : ::. .::.:. .: 
XP_006 LTNIAMRPGLEGYALPRKCNTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPH
      180       190       200       210       220       230        

              220       230       240                 250       260
pF1KB5 GQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRC----LPGKKG------GYTSGTFRTVL
       :..:: ...  :  : ::. ::.:: ..: :      :  ..:      :  :. .:.. 
XP_006 GEMPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLG
      240       250       260       270       280       290        

              270       280       290       300       310       320
pF1KB5 IACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKAILCL
       :  ..   ...   . : ..  ......     .... ..::.:::: :   .:::: ::
XP_006 IQVDTDGSGRSFAGAVSPQEEEEFRRLAAL--PNVYEVISKSIAPSIFGGTDMKKAIACL
      300       310       320         330       340       350      

              330       340       350       360       370       380
pF1KB5 LLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTA
       :.:: .. : .:   :::::.:..:::..::::::..:   .: .. :.:.:::..::::
XP_006 LFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTA
        360       370       380       390       400       410      

              390       400       410       420       430       440
pF1KB5 AVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHA
       .:  :  . .  .:.::::::: ::::::::::: . ::.::::.:::  ..:::::: .
XP_006 SVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITT
        420       430       440       450       460       470      

              450       460       470       480       490       500
pF1KB5 RLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDH
        ::.::::::::: :.::.:. :   .:: .. ..:::::..::. :. . :.:  .. :
XP_006 TLNSRCSVLAAANSVFGRWDETKGE-DNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKH
        480       490       500        510       520       530     

              510       520       530       540       550       560
pF1KB5 VLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQEDQQDTQIYEKHDNLLHGTKKKKE
       :. .:                  :. :.            .::  : . .:         
XP_006 VITLH------------------VSALT------------QTQAVEGEIDL---------
         540                                     550               

              570        580       590          600       610      
pF1KB5 KMVSAAFMKKYIHVAKI-IKPVLTQESATYIAEEYSRLRS---QDSMSSDTARTSPVTAR
            : .::.:   ..   : :. :.:  . ..:  .::   :   .::   . :.:.:
XP_006 -----AKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVR
             560       570       580       590       600       610 

        620       630       640       650       660       670      
pF1KB5 TLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSEDESETED
        ::...:.: : .: ...  .   :.:::..: : . .  .:   .   .  :  .  ::
XP_006 QLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAAL---SGTLSGVEGFTSQED
             620       630       640       650          660        

        680       690       700       710       720       730      
pF1KB5 EEEKSQEDQEQKRKRRKTRQPDAKDGDSYDPYDFSDTEEEMPQVHTPKTADSQETKESQK
       .:  :. ... ::.                                              
XP_006 QEMLSRIEKQLKRRFAIGSQVSEHSIIKDFTKQLSLLSGQAKASETETDRDRDERQTELE
      670       680       690       700       710       720        

>>NP_006730 (OMIM: 602696) DNA replication licensing fac  (734 aa)
 initn: 868 init1: 625 opt: 856  Z-score: 600.3  bits: 121.8 E(85289): 1.1e-26
Smith-Waterman score: 995; 31.3% identity (58.1% similar) in 718 aa overlap (3-690:17-682)

                             10          20           30        40 
pF1KB5               MAGTVVLDDVELREAQ--RDYLDFLDDEE---DQGIYQSKVRELIS
                       : .  :. . :..:  : . .:: . .   :.  .  : :. ..
NP_006 MSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELK
               10        20        30        40        50        60

                  50        60        70        80           90    
pF1KB5 DN----QYRLIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALK---DFVASIDATYAKQ
        .    .: . :...::   .:  :. : ..  :.:  ...: :   : :.    .  . 
NP_006 RHYNLGEYWIEVEMEDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEV
               70        80        90       100       110       120

          100       110       120       130       140       150    
pF1KB5 YEEFYVGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKT
        ... : :...  ..  : :.: : ..: .: . ::.   : :: :..:    : . ..:
NP_006 LQDIQVMLKSD--ASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNT
              130         140       150       160       170        

           160       170       180       190          200       210
pF1KB5 IER-RYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYK---DHQTITIQEMPEKAPA
       .    .       :.: .       . . ::.  . .       : ::. .::.:. .: 
NP_006 LTNIAMRPGLEGYALPRKCNTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPH
      180       190       200       210       220       230        

              220       230       240                 250       260
pF1KB5 GQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRC----LPGKKG------GYTSGTFRTVL
       :..:: ...  :  : ::. ::.:: ..: :      :  ..:      :  :. .:.. 
NP_006 GEMPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLG
      240       250       260       270       280       290        

              270       280       290       300       310       320
pF1KB5 IACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKAILCL
       :  ..   ...   . : ..  ......     .... ..::.:::: :   .:::: ::
NP_006 IQVDTDGSGRSFAGAVSPQEEEEFRRLAAL--PNVYEVISKSIAPSIFGGTDMKKAIACL
      300       310       320         330       340       350      

              330       340       350       360       370       380
pF1KB5 LLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTA
       :.:: .. : .:   :::::.:..:::..::::::..:   .: .. :.:.:::..::::
NP_006 LFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTA
        360       370       380       390       400       410      

              390       400       410       420       430       440
pF1KB5 AVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHA
       .:  :  . .  .:.::::::: ::::::::::: . ::.::::.:::  ..:::::: .
NP_006 SVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITT
        420       430       440       450       460       470      

              450       460       470       480       490       500
pF1KB5 RLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDH
        ::.::::::::: :.::.:. :   .:: .. ..:::::..::. :. . :.:  .. :
NP_006 TLNSRCSVLAAANSVFGRWDETKGE-DNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKH
        480       490       500        510       520       530     

              510       520       530       540       550       560
pF1KB5 VLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQEDQQDTQIYEKHDNLLHGTKKKKE
       :. .:                  :. :.            .::  : . .:         
NP_006 VITLH------------------VSALT------------QTQAVEGEIDL---------
         540                                     550               

              570        580       590          600       610      
pF1KB5 KMVSAAFMKKYIHVAKI-IKPVLTQESATYIAEEYSRLRS---QDSMSSDTARTSPVTAR
            : .::.:   ..   : :. :.:  . ..:  .::   :   .::   . :.:.:
NP_006 -----AKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVR
             560       570       580       590       600       610 

        620       630       640       650       660       670      
pF1KB5 TLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSEDESETED
        ::...:.: : .: ...  .   :.:::..: : . .  .:   .   .  :  .  ::
NP_006 QLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAAL---SGTLSGVEGFTSQED
             620       630       640       650          660        

        680       690       700       710       720       730      
pF1KB5 EEEKSQEDQEQKRKRRKTRQPDAKDGDSYDPYDFSDTEEEMPQVHTPKTADSQETKESQK
       .:  :. ... ::.                                              
NP_006 QEMLSRIEKQLKRRFAIGSQVSEHSIIKDFTKQKYPEHAIHKVLQLMLRRGEIQHRMQRK
      670       680       690       700       710       720        




808 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 16:15:12 2016 done: Sat Nov  5 16:15:14 2016
 Total Scan time: 13.300 Total Display time:  0.210

Function used was FASTA [36.3.4 Apr, 2011]
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